JUN SUGIMOTO

Last Updated :2024/05/08

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Assistant Professor
E-mail
junshiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
  • 2017/11/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
  • 2011/08/01, University of the Ryukyus, Assistant Professor
  • 2010/10/01, Toyama University, Assistant Professor
  • 2009/08/01, Case Western Reserve University, Postdoctoral fellow
  • 2006/08/01, University of the missouri, Postdoctoral fellow
  • 2007/04/01, University of the Ryukyus, Assistant Professor
  • 1999/06/01, University of the Ryukyus, Research Associate

Academic Degrees

  • Toyama University
  • Toyama University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Obstetrics and gynecology

Research Keywords

  • Human endogenous retroviruses
  • placenta

Affiliated Academic Societies

  • Japan placenta association
  • The molecular biology society of Japan
  • The Japan society of human genetics
  • Japan Society of Obstetrics and Gynecology

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Year, Systemic Disease Control
  2. 2024, Undergraduate Education, Intensive, Practice for medical research
  3. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2024, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
  5. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Obstetrics and Gynecology
  6. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Obstetrics and Gynecology
  7. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Obstetrics and Gynecology
  8. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Obstetrics and Gynecology
  9. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Gynecologic Cancer Treatment
  10. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Gynecologic Cancer Treatment

Research Activities

Academic Papers

  1. ★, Involvement of the HERV-derived cell-fusion inhibitor, suppressyn, in the fusion defects characteristic of the trisomy 21 placenta, SCIENTIFIC REPORTS, 12(1), 20220622
  2. Distribution of amniotic stem cells in human term amnion membrane, MICROSCOPY, 71(1), 66-76, 20220129
  3. Progesterone Suppresses Uterine Contraction by Reducing Odontogenic Porphyromonas gingivalis Induced Chronic Inflammation in Mice, BIOMOLECULES, 12(8), 202208
  4. ★, Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua?, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(19), 20210923
  5. Syncytins expressed in human placental trophoblast, PLACENTA, 113, 8-14, 20210915
  6. The Immunology of Syncytialized Trophoblast, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(4), 202102
  7. Predictive Accuracy of Soluble FMS-Like Tyrosine Kinase-1/Placental Growth Factor Ratio for Preeclampsia in Japan: A Systematic Review, HYPERTENSION RESEARCH IN PREGNANCY, 9(1), 1-7, 202102
  8. Porphyromonas gingivalis, a cause of preterm birth in mice, induces an inflammatory response in human amnion mesenchymal cells but not epithelial cells, PLACENTA, 99, 21-26, 20200915
  9. Localization of Indoleamine 2,3-Dioxygenase-1 and Indoleamine 2,3-Dioxygenase-2 at the Human Maternal-Fetal Interface, INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH, 13, 202012
  10. Indoleamine 2,3-dioxygenase and trophoblast invasion in caesarean scar pregnancy: Implications for the aetiopathogenesis of placenta accreta spectrum, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 138, 202004
  11. ★, Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation, SCIENTIFIC REPORTS, 9, 20191220
  12. Regulation of REG4 Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma, CANCER GENOMICS & PROTEOMICS, 16(6), 481-490, 201911
  13. Human Amnion-derived Stem Cells have Immunosuppressive Properties on NK cells and Monocytes., Cell Transplant, Oct 20, 2014
  14. Magnesium sulfate increases intracellular magnesium reducing inflammatory cytokine release in neonates., Am J Reprod Immunol., 17., 201304
  15. ★, A novel human endogenous retroviral protein inhibits cell-cell fusion., Sci Rep, 15;3:1462., 201303
  16. ★, Magnesium decreases inflammatory cytokine production: a novel innate immunomodulatory mechanism., Journal of immunology., 188(12):6338-6346., 20120615
  17. Potential Mechanisms for Increased HIV-1 Transmission Across the Endocervical Epithelium During C. trachomatis Infection., Curr HIV Res., 20120229
  18. Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms., Infectious Diseases in Obstetrics and Gynecology, 420905, 20110529
  19. Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions., Hum Reprod., 24(12):3160-71, 200912
  20. ★, Human endogenous retroviruses and the placenta., Reproductive Sciences, 16(11), 1023-1033, 2009
  21. Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia., J Psychiatr Res., 41(12):, 1042-6., 2007
  22. Tissue-specificity in methylation and expression of human genes coding for neuropeptides and their receptors and a human endogenous retrovirus K family., J. Hum. Genet., 51(5), 440-450, 2006
  23. Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study., Ann Hum Genet., 68(Pt 3), 196-204, 200405
  24. Expression analyses of human endogenous retroviruses (HERVs): tissue-specific and developmental stage-dependent expression of HERVs., Genomics, 84(6), 982-990, 2004
  25. Human endogenous retroviruses with transcriptional potential in the brain., J. Hum. Genet., 48(11), 575-581, 2003
  26. Identification of nonsynonymous polymorphisms in the superantigen-coding region of IDDMK1,2 22 and a pilot study on the association between IDDMK1,2 22 and type 1 diabetes., J. Hum. Genet., 46(12), 712-716, 2001
  27. Search for active endogenous retrovirus: identification and characterization of a HERV-E gene that is expressed in the pancreas and thyroid., J. Hum. Genet., 46(11), 619-625, 2001
  28. ★, Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping., Genomics, 1 72(2), 137-144, 2001
  29. Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia., Oncogene, 19 (23), 2796-2802, 2000
  30. ★, Identification of the TCL1/MTCP1-like 1(TML1) gene from the region next to the TCL1 locus, Cancer Res, 59 (10), 2313-2317, 1999
  31. Isolation and mapping of a polymorphic CA repeat sequence at the human VRK1 locus., J Hum Genet, 44 (2), 133-134, 1999
  32. Isolation and mapping of a putative b subunit of human ATP synthase (ATP-BL) from human leukocytes., DNA Res, 6 (1), 29-35, 1999
  33. Assignment of the human poly(A) polymerase (PAP) gene to chromosome14q32.1-q32.2 and isolation of a polymorphic CA repeat sequence., J Hum Genet, 44 (4), 253-255, 1999

Publications such as books

  1. 2019/12/01, Basic and clinical placentology, Placenta and Human endogenous retroviruses, suppressyn, Medical View, 2019, 12, Scholarly Book, Joint work, 日本語, 978-4-7583-1762-7

Invited Lecture, Oral Presentation, Poster Presentation

  1. Deletion of a mouse retrovirus-derived cell fusion suppressor gene induces abnormal placental formation, Jun Sugimoto, Yoshiki Kudo, The 73rd Annual congress of the Japan society of obstetrics and gynecology, 2022, Without Invitation, Japanese
  2. Expression of the cell fusion inhibitor, Suppressyn, in hypertensive disorders of pregnancy, Jun Sugimoto, Tomomi Yamazaki, Yuriko Omori, Yoshiki Kudo, The 73rd Annual congress of the Japan society of obstetrics and gynecology, 2021, Without Invitation, English
  3. O2 responses suggest a central role for suppressyn in trophoblast cell fusion, Jun Sugimoto, Yoshiki Kudo, The 72nd Annual congress of the Japan society of obstetrics and gynecology, 2020, Without Invitation, English
  4. Expression of the suppressyn protein in trisomy 21 placenta, Jun Sugimoto, Tomomi Yamazaki, Danny Schust, Yoshiki Kudo, 2019/.4, Without Invitation, English
  5. Suppressive effect of nicotine on nutrient transport system in BeWo cells, Takako Sadakane, Jun Sugimoto, Yoshiki Kudo, 2019, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2020, 2022