JUN SUGIMOTO

Last Updated :2025/05/09

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Assistant Professor
E-mail
junshiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
  • 2017/11/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
  • 2011/08/01, University of the Ryukyus, Assistant Professor
  • 2010/10/01, Toyama University, Assistant Professor
  • 2009/08/01, Case Western Reserve University, Postdoctoral fellow
  • 2006/08/01, University of the missouri, Postdoctoral fellow
  • 2007/04/01, University of the Ryukyus, Assistant Professor
  • 1999/06/01, University of the Ryukyus, Research Associate

Academic Degrees

  • Toyama University
  • Toyama University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Obstetrics and gynecology

Research Keywords

  • Human endogenous retroviruses
  • placenta

Affiliated Academic Societies

  • Japan placenta association
  • The molecular biology society of Japan
  • The Japan society of human genetics
  • Japan Society of Obstetrics and Gynecology

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Systemic Disease Control
  2. 2025, Undergraduate Education, Intensive, Practice for medical research
  3. 2025, Undergraduate Education, Intensive, Practice of Medicine I

Research Activities

Academic Papers

  1. The Role of the Placental Enzyme Indoleamine 2,3-Dioxygenase in Normal and Abnormal Human Pregnancy, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(8), 202404
    Link to Paper Search Results by DOI
  2. Controlling Trophoblast Cell Fusion in the Human Placenta-Transcriptional Regulation of Suppressyn, an Endogenous Inhibitor of Syncytin-1, BIOMOLECULES, 13(11), 202311
    Link to Paper Search Results by DOI
  3. Selective Inhibition of L-type Amino Acid Transporter 1 Suppresses Cell Proliferation in Ovarian Clear Cell Carcinoma, ANTICANCER RESEARCH, 43(6), 2509-2517, 202306
    Link to Paper Search Results by DOI
  4. ★, Involvement of the HERV-derived cell-fusion inhibitor, suppressyn, in the fusion defects characteristic of the trisomy 21 placenta, SCIENTIFIC REPORTS, 12(1), 20220622
    Link to Paper Search Results by DOI
  5. Distribution of amniotic stem cells in human term amnion membrane, MICROSCOPY, 71(1), 66-76, 20220129
    Link to Paper Search Results by DOI
  6. Progesterone Suppresses Uterine Contraction by Reducing Odontogenic Porphyromonas gingivalis Induced Chronic Inflammation in Mice, BIOMOLECULES, 12(8), 202208
    Link to Paper Search Results by DOI
  7. ★, Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua?, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(19), 20210923
    Link to Paper Search Results by DOI
  8. Syncytins expressed in human placental trophoblast, PLACENTA, 113, 8-14, 20210915
    Link to Paper Search Results by DOI
  9. The Immunology of Syncytialized Trophoblast, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(4), 202102
    Link to Paper Search Results by DOI
  10. Predictive Accuracy of Soluble FMS-Like Tyrosine Kinase-1/Placental Growth Factor Ratio for Preeclampsia in Japan: A Systematic Review, HYPERTENSION RESEARCH IN PREGNANCY, 9(1), 1-7, 202102
    Link to Paper Search Results by DOI
  11. Porphyromonas gingivalis, a cause of preterm birth in mice, induces an inflammatory response in human amnion mesenchymal cells but not epithelial cells, PLACENTA, 99, 21-26, 20200915
    Link to Paper Search Results by DOI
  12. Localization of Indoleamine 2,3-Dioxygenase-1 and Indoleamine 2,3-Dioxygenase-2 at the Human Maternal-Fetal Interface, INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH, 13, 202012
    Link to Paper Search Results by DOI
  13. Indoleamine 2,3-dioxygenase and trophoblast invasion in caesarean scar pregnancy: Implications for the aetiopathogenesis of placenta accreta spectrum, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 138, 202004
    Link to Paper Search Results by DOI
  14. ★, Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation, SCIENTIFIC REPORTS, 9, 20191220
    Link to Paper Search Results by DOI
  15. Regulation of REG4 Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma, CANCER GENOMICS & PROTEOMICS, 16(6), 481-490, 201911
    Link to Paper Search Results by DOI
  16. Human Amnion-derived Stem Cells have Immunosuppressive Properties on NK cells and Monocytes., Cell Transplant, Oct 20, 2014
  17. Magnesium sulfate increases intracellular magnesium reducing inflammatory cytokine release in neonates., Am J Reprod Immunol., 17., 201304
  18. ★, A novel human endogenous retroviral protein inhibits cell-cell fusion., Sci Rep, 15;3:1462., 201303
  19. ★, Magnesium decreases inflammatory cytokine production: a novel innate immunomodulatory mechanism., Journal of immunology., 188(12):6338-6346., 20120615
  20. Potential Mechanisms for Increased HIV-1 Transmission Across the Endocervical Epithelium During C. trachomatis Infection., Curr HIV Res., 20120229
  21. Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms., Infectious Diseases in Obstetrics and Gynecology, 420905, 20110529
  22. Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions., Hum Reprod., 24(12):3160-71, 200912
  23. ★, Human endogenous retroviruses and the placenta., Reproductive Sciences, 16(11), 1023-1033, 2009
  24. Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia., J Psychiatr Res., 41(12):, 1042-6., 2007
  25. Tissue-specificity in methylation and expression of human genes coding for neuropeptides and their receptors and a human endogenous retrovirus K family., J. Hum. Genet., 51(5), 440-450, 2006
  26. Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study., Ann Hum Genet., 68(Pt 3), 196-204, 200405
  27. Expression analyses of human endogenous retroviruses (HERVs): tissue-specific and developmental stage-dependent expression of HERVs., Genomics, 84(6), 982-990, 2004
  28. Human endogenous retroviruses with transcriptional potential in the brain., J. Hum. Genet., 48(11), 575-581, 2003
  29. Identification of nonsynonymous polymorphisms in the superantigen-coding region of IDDMK1,2 22 and a pilot study on the association between IDDMK1,2 22 and type 1 diabetes., J. Hum. Genet., 46(12), 712-716, 2001
  30. Search for active endogenous retrovirus: identification and characterization of a HERV-E gene that is expressed in the pancreas and thyroid., J. Hum. Genet., 46(11), 619-625, 2001
  31. ★, Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping., Genomics, 1 72(2), 137-144, 2001
  32. Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia., Oncogene, 19 (23), 2796-2802, 2000
  33. ★, Identification of the TCL1/MTCP1-like 1(TML1) gene from the region next to the TCL1 locus, Cancer Res, 59 (10), 2313-2317, 1999
  34. Isolation and mapping of a polymorphic CA repeat sequence at the human VRK1 locus., J Hum Genet, 44 (2), 133-134, 1999
  35. Isolation and mapping of a putative b subunit of human ATP synthase (ATP-BL) from human leukocytes., DNA Res, 6 (1), 29-35, 1999
  36. Assignment of the human poly(A) polymerase (PAP) gene to chromosome14q32.1-q32.2 and isolation of a polymorphic CA repeat sequence., J Hum Genet, 44 (4), 253-255, 1999

Publications such as books

  1. 2019/12/01, Basic and clinical placentology, Placenta and Human endogenous retroviruses, suppressyn, Medical View, 2019, 12, Scholarly Book, Joint work, 日本語, 978-4-7583-1762-7

Invited Lecture, Oral Presentation, Poster Presentation

  1. Deletion of a mouse retrovirus-derived cell fusion suppressor gene induces abnormal placental formation, Jun Sugimoto, Yoshiki Kudo, The 73rd Annual congress of the Japan society of obstetrics and gynecology, 2022, Without Invitation, Japanese
  2. Expression of the cell fusion inhibitor, Suppressyn, in hypertensive disorders of pregnancy, Jun Sugimoto, Tomomi Yamazaki, Yuriko Omori, Yoshiki Kudo, The 73rd Annual congress of the Japan society of obstetrics and gynecology, 2021, Without Invitation, English
  3. O2 responses suggest a central role for suppressyn in trophoblast cell fusion, Jun Sugimoto, Yoshiki Kudo, The 72nd Annual congress of the Japan society of obstetrics and gynecology, 2020, Without Invitation, English
  4. Expression of the suppressyn protein in trisomy 21 placenta, Jun Sugimoto, Tomomi Yamazaki, Danny Schust, Yoshiki Kudo, 2019/.4, Without Invitation, English
  5. Suppressive effect of nicotine on nutrient transport system in BeWo cells, Takako Sadakane, Jun Sugimoto, Yoshiki Kudo, 2019, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. 2023, 2025
  2. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2020, 2022