JUN SUGIMOTO
Last Updated :2023/11/01
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Medicine), Assistant Professor
- E-mail
- juns
hiroshima-u.ac.jp
Basic Information
Major Professional Backgrounds
- 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
- 2017/11/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor
- 2011/08/01, University of the Ryukyus, Assistant Professor
- 2010/10/01, Toyama University, Assistant Professor
- 2009/08/01, Case Western Reserve University, Postdoctoral fellow
- 2006/08/01, University of the missouri, Postdoctoral fellow
- 2007/04/01, University of the Ryukyus, Assistant Professor
- 1999/06/01, University of the Ryukyus, Research Associate
Academic Degrees
- Toyama University
- Toyama University
Educational Activity
- [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine
Research Fields
- Medicine,dentistry, and pharmacy;Clinical surgery;Obstetrics and gynecology
Research Keywords
- Human endogenous retroviruses
- placenta
Affiliated Academic Societies
- Japan placenta association
- The molecular biology society of Japan
- The Japan society of human genetics
- Japan Society of Obstetrics and Gynecology
Educational Activity
Course in Charge
- 2023, Undergraduate Education, Year, Systemic Disease Control
- 2023, Undergraduate Education, Intensive, Practice for medical research
- 2023, Undergraduate Education, Intensive, Practice of Medicine I
- 2023, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Obstetrics and Gynecology
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Obstetrics and Gynecology
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Obstetrics and Gynecology
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Obstetrics and Gynecology
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Gynecologic Cancer Treatment
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Gynecologic Cancer Treatment
Research Activities
Academic Papers
- ★, Involvement of the HERV-derived cell-fusion inhibitor, suppressyn, in the fusion defects characteristic of the trisomy 21 placenta, SCIENTIFIC REPORTS, 12(1), 20220622
- Distribution of amniotic stem cells in human term amnion membrane, MICROSCOPY, 71(1), 66-76, 20220129
- Progesterone Suppresses Uterine Contraction by Reducing Odontogenic Porphyromonas gingivalis Induced Chronic Inflammation in Mice, BIOMOLECULES, 12(8), 202208
- ★, Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua?, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(19), 20210923
- Syncytins expressed in human placental trophoblast, PLACENTA, 113, 8-14, 20210915
- The Immunology of Syncytialized Trophoblast, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(4), 202102
- Predictive Accuracy of Soluble FMS-Like Tyrosine Kinase-1/Placental Growth Factor Ratio for Preeclampsia in Japan: A Systematic Review, HYPERTENSION RESEARCH IN PREGNANCY, 9(1), 1-7, 202102
- Porphyromonas gingivalis, a cause of preterm birth in mice, induces an inflammatory response in human amnion mesenchymal cells but not epithelial cells, PLACENTA, 99, 21-26, 20200915
- Localization of Indoleamine 2,3-Dioxygenase-1 and Indoleamine 2,3-Dioxygenase-2 at the Human Maternal-Fetal Interface, INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH, 13, 202012
- Indoleamine 2,3-dioxygenase and trophoblast invasion in caesarean scar pregnancy: Implications for the aetiopathogenesis of placenta accreta spectrum, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 138, 202004
- ★, Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation, SCIENTIFIC REPORTS, 9, 20191220
- Regulation of REG4 Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma, CANCER GENOMICS & PROTEOMICS, 16(6), 481-490, 201911
- Human Amnion-derived Stem Cells have Immunosuppressive Properties on NK cells and Monocytes., Cell Transplant, Oct 20, 2014
- Magnesium sulfate increases intracellular magnesium reducing inflammatory cytokine release in neonates., Am J Reprod Immunol., 17., 201304
- ★, A novel human endogenous retroviral protein inhibits cell-cell fusion., Sci Rep, 15;3:1462., 201303
- ★, Magnesium decreases inflammatory cytokine production: a novel innate immunomodulatory mechanism., Journal of immunology., 188(12):6338-6346., 20120615
- Potential Mechanisms for Increased HIV-1 Transmission Across the Endocervical Epithelium During C. trachomatis Infection., Curr HIV Res., 20120229
- Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms., Infectious Diseases in Obstetrics and Gynecology, 420905, 20110529
- Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions., Hum Reprod., 24(12):3160-71, 200912
- ★, Human endogenous retroviruses and the placenta., Reproductive Sciences, 16(11), 1023-1033, 2009
- Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia., J Psychiatr Res., 41(12):, 1042-6., 2007
- Tissue-specificity in methylation and expression of human genes coding for neuropeptides and their receptors and a human endogenous retrovirus K family., J. Hum. Genet., 51(5), 440-450, 2006
- Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study., Ann Hum Genet., 68(Pt 3), 196-204, 200405
- Expression analyses of human endogenous retroviruses (HERVs): tissue-specific and developmental stage-dependent expression of HERVs., Genomics, 84(6), 982-990, 2004
- Human endogenous retroviruses with transcriptional potential in the brain., J. Hum. Genet., 48(11), 575-581, 2003
- Identification of nonsynonymous polymorphisms in the superantigen-coding region of IDDMK1,2 22 and a pilot study on the association between IDDMK1,2 22 and type 1 diabetes., J. Hum. Genet., 46(12), 712-716, 2001
- Search for active endogenous retrovirus: identification and characterization of a HERV-E gene that is expressed in the pancreas and thyroid., J. Hum. Genet., 46(11), 619-625, 2001
- ★, Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping., Genomics, 1 72(2), 137-144, 2001
- Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia., Oncogene, 19 (23), 2796-2802, 2000
- ★, Identification of the TCL1/MTCP1-like 1(TML1) gene from the region next to the TCL1 locus, Cancer Res, 59 (10), 2313-2317, 1999
- Isolation and mapping of a polymorphic CA repeat sequence at the human VRK1 locus., J Hum Genet, 44 (2), 133-134, 1999
- Isolation and mapping of a putative b subunit of human ATP synthase (ATP-BL) from human leukocytes., DNA Res, 6 (1), 29-35, 1999
- Assignment of the human poly(A) polymerase (PAP) gene to chromosome14q32.1-q32.2 and isolation of a polymorphic CA repeat sequence., J Hum Genet, 44 (4), 253-255, 1999
Publications such as books
- 2019/12/01, Basic and clinical placentology, Placenta and Human endogenous retroviruses, suppressyn, Medical View, 2019, 12, Scholarly Book, Joint work, 日本語, 978-4-7583-1762-7
Invited Lecture, Oral Presentation, Poster Presentation
- Deletion of a mouse retrovirus-derived cell fusion suppressor gene induces abnormal placental formation, Jun Sugimoto, Yoshiki Kudo, The 73rd Annual congress of the Japan society of obstetrics and gynecology, 2022, Without Invitation, Japanese
- Expression of the cell fusion inhibitor, Suppressyn, in hypertensive disorders of pregnancy, Jun Sugimoto, Tomomi Yamazaki, Yuriko Omori, Yoshiki Kudo, The 73rd Annual congress of the Japan society of obstetrics and gynecology, 2021, Without Invitation, English
- O2 responses suggest a central role for suppressyn in trophoblast cell fusion, Jun Sugimoto, Yoshiki Kudo, The 72nd Annual congress of the Japan society of obstetrics and gynecology, 2020, Without Invitation, English
- Expression of the suppressyn protein in trisomy 21 placenta, Jun Sugimoto, Tomomi Yamazaki, Danny Schust, Yoshiki Kudo, 2019/.4, Without Invitation, English
- Suppressive effect of nicotine on nutrient transport system in BeWo cells, Takako Sadakane, Jun Sugimoto, Yoshiki Kudo, 2019, Without Invitation, English
External Funds
Acceptance Results of Competitive Funds
- KAKENHI(Grant-in-Aid for Scientific Research (C)), 2020, 2022