Last Updated :2024/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Professor (Special Recognition)
I have been taking part in the neuroimaging research in depression and stress related psychiatric disorders to understand their pathophysiology and improve the diagnosis and treatment.

Basic Information

Academic Degrees

  • Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Psychiatric science

Research Keywords

  • depression
  • neuroimaging

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 4Term, Brain Science
  2. 2024, Undergraduate Education, Intensive, Medical Neuroscience II
  3. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2024, Undergraduate Education, 1Term, Psychiatry
  5. 2024, Undergraduate Education, 1Term, Psychiatry
  6. 2024, Graduate Education (Master's Program) , Second Semester, General Clinical Medicine and Dentistry
  7. 2024, Graduate Education (Master's Program) , 1Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance A
  8. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Psychiatry and Neurosciences
  9. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Psychiatry and Neurosciences
  10. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Psychiatry and Neurosciences
  11. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Psychiatry and Neurosciences
  12. 2024, Graduate Education (Master's Program) , Year, Practicum in Psychology A

Research Activities

Academic Papers

  1. Interferon signaling and hypercytokinemia-related gene expression in the blood of antidepressant non-responders, HELIYON, 9(1), 202301
  2. ★, Examining the usefulness of the brain network marker program using fMRI for the diagnosis and stratification of major depressive disorder: a non-randomized study protocol, BMC PSYCHIATRY, 23(1), 20230124
  3. ★, Verification of the brain network marker of major depressive disorder: Test-retest reliability and anterograde generalization performance for newly acquired data, JOURNAL OF AFFECTIVE DISORDERS, 326, 262-266, 20230401
  4. Day-to-day regularity and diurnal switching of physical activity reduce depression-related behaviors: a time-series analysis of wearable device data, BMC PUBLIC HEALTH, 23(1), 20230106
  5. Maximum Credibility Voting (MCV) - An Integrative Approach for Accurate Diagnosis of Major Depressive Disorder from Clinically Readily Available Data, APSIPA TRANSACTIONS ON SIGNAL AND INFORMATION PROCESSING, 11(1), 2022
  6. The neuroanatomy of social trust predicts depression vulnerability, SCIENTIFIC REPORTS, 12(1), 20221006
  7. ★, Left DLPFC activity is associated with plasma kynurenine levels and can predict treatment response to escitalopram in major depressive disorder, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 76(8), 367-376, 202208
  8. ★, Trace of depression: Network structure of depressive symptoms in different clinical conditions, EUROPEAN PSYCHIATRY, 65(1), 20220311
  9. Decreased physical activity with subjective pleasure is associated with avoidance behaviors, SCIENTIFIC REPORTS, 12(1), 20220218
  10. ★, Attenuated left prefrontal activation during a verbal fluency task in patients with depression., Neuropsychobiology, 47, 21-26, 20030401
  11. Brain activity during expectancy of emotional stimuli: an fMRI study., NeuroReport, 14, 51-55, 20030401
  12. Negative correlation between right prefrontal activity during response inhibition and impulsiveness: A fMRI study., European Archives of Psychiatry and Clinical Neuroscience, 254, 245-251, 20040401
  13. ★, Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops., Nature Neuroscience, 7, 887-893, 20040401
  14. Brain mechanism of reward prediction under predictable and unpredictable environmental dynamics., Neural Networks in Healthcare: Potential and Challenges, 19, 1233-1241, 20060401
  15. Gender differences in brain activity toward unpleasant linguistic stimuli concerning interpersonal relationships: an fMRI study., European Archives of Psychiatry and Clinical Neuroscience, 255, 327-333, 20050401
  16. ★, Reduced activation of posterior cingulate cortex during imagery in subjects with high degrees of alexithymia: a functional magnetic resonance imaging study., Biological Psychiatry, 57, 982-990, 20050401
  17. ★, Attenuated anterior cingulate activation during a verbal fluency task in elderly patients with a history of multiple-episode depression., American Journal of Geriatric Psychiatry, 15(7), 594-603, 20070701
  18. ★, Modulation of default-mode network activity by acute tryptophan depletion is associated with mood change: A resting state functional magnetic resonance imaging study, NEUROSCIENCE RESEARCH, 69(2), 129-134, 201102
  19. Personality traits and the amplitude of spontaneous low-frequency oscillations during resting state, NEUROSCIENCE LETTERS, 492(2), 109-113, 2011
  20. Inter-individual discount factor differences in reward prediction are topographically associated with caudate activation, EXPERIMENTAL BRAIN RESEARCH, 212(4), 593-601, 201108
  21. ★, The Effect of Negative and Positive Emotionality on Associative Memory: An fMRI Study, PLOS ONE, 6(9), 2011
  22. ★, Neural and Personality Correlates of Individual Differences Related to the Effects of Acute Tryptophan Depletion on Future Reward Evaluation, NEUROPSYCHOBIOLOGY, 65(2), 55-64, 2012
  23. Sadness Enhances the Experience of Pain and Affects Pain-Evoked Cortical Activities: An MEG Study, JOURNAL OF PAIN, 13(7), 628-635, 201207
  24. Effects of depression on reward-based decision making and variability of action in probabilistic learning, JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY, 43(4), 1088-1094, 201212
  26. Depressive symptoms and apathy are associated with psychomotor slowness and frontal activation, EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 262(6), 493-499, 201209
  27. Cognitive behavioral therapy for depression changes medial prefrontal and ventral anterior cingulate cortex activity associated with self-referential processing, SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 9(4), 487-493, 201403
  28. Psychosocial functioning is correlated with activation in the anterior cingulate cortex and left lateral prefrontal cortex during a verbal fluency task in euthymic bipolar disorder: A preliminary fMRI study, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 68(3), 188-196, 201403
  29. Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: An exploratory magnetic resonance imaging voxel-based morphometry study, JOURNAL OF AFFECTIVE DISORDERS, 168, 229-235, 2014
  30. Hippocampal activation during associative encoding of word pairs and its relation to symptomatic improvement in depression: A functional and volumetric MRI study, JOURNAL OF AFFECTIVE DISORDERS, 152, 462-467, 201401
  31. fMRI Study of Social Anxiety during Social Ostracism with and without Emotional Support, PLOS ONE, 10(5), 2015
  32. Direct and indirect influences of childhood abuse on depression symptoms in patients with major depressive disorder, BMC PSYCHIATRY, 15, 2015
  33. ★, Behavioral activation can normalize neural hypoactivation in subthreshold depression during a monetary incentive delay task, JOURNAL OF AFFECTIVE DISORDERS, 189, 254-262, 2016
  34. ★, Childhood poverty and recruitment of adult emotion regulatory neurocircuitry, SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 10(11), 1596-1606, 201511
  35. ★, Changes in the regional cerebral blood flow detected by arterial spin labeling after 6-week escitalopram treatment for major depressive disorder, JOURNAL OF AFFECTIVE DISORDERS, 194, 135-143, 201604
  36. ★, Association of thalamic hyperactivity with treatment-resistant depression and poor response in early treatment for major depression: a resting-state fMRI study using fractional amplitude of low-frequency fluctuations, TRANSLATIONAL PSYCHIATRY, 6, 2016
  37. Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices, JOURNAL OF AFFECTIVE DISORDERS, 208, 610-614, 2017
  38. Increased amygdala reactivity following early life stress: a potential resilience enhancer role, BMC PSYCHIATRY, 17, 2017
  39. ★, Effects of behavioural activation on the neural basis of other perspective self-referential processing in subthreshold depression: a functional magnetic resonance imaging study, PSYCHOLOGICAL MEDICINE, 47(5), 877-888, 201704
  40. ★, Disrupted Brain Activation and Deactivation Pattern during Semantic Verbal Fluency Task in Patients with Major Depression, NEUROPSYCHOBIOLOGY, 74(2), 69-77, 2016
  41. Neural circuitry of emotion regulation: Effects of appraisal, attention, and cortisol administration, COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE, 17(2), 437-451, 201704
  42. Regional brain functions in the resting state indicative of potential differences between depression and chronic pain, SCIENTIFIC REPORTS, 7, 2017
  43. The neural correlates of the metacognitive function of other perspective: a multiple regression analysis study, NEUROREPORT, 28(11), 671-676, 2017
  44. Prediction of clinical depression scores and detection of changes in whole-brain using resting-state functional MRI data with partial least squares regression, PLOS ONE, 12(7), 2017
  45. Patients with major depressive disorder exhibit reduced reward size coding in the striatum, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 79, 317-323, 2017
  46. Multiple co-clustering based on nonparametric mixture models with heterogeneous marginal distributions, PLOS ONE, 12(10), 2017
  47. BDNF as a possible modulator of EEG oscillatory response at the parietal cortex during visuo-tactile integration processes using a rubber hand, NEUROSCIENCE RESEARCH, 124, 16-24, 201711
  48. Functional alterations of Postcentral gyrus Modulated by angry Facial expressions during intraoral Tactile stimuli in Patients with Burning Mouth syndrome: a Functional Magnetic resonance imaging study, FRONTIERS IN PSYCHIATRY, 8, 2017
  49. Effects of behavioral activation on default mode network connectivity in subthreshold depression: A preliminary resting-state fMRI study, JOURNAL OF AFFECTIVE DISORDERS, 227, 156-163, 201802
  50. Changes in resting-state brain networks after cognitive-behavioral therapy for chronic pain, PSYCHOLOGICAL MEDICINE, 48(7), 1148-1156, 201805
  51. ★, Effects of behavioural activation on the neural circuit related to intrinsic motivation, BJPSYCH OPEN, 4(5), 317-323, 201809
  52. A prediction model of working memory across health and psychiatric disease using whole-brain functional connectivity, ELIFE, 7, 20181210
  53. Distinctive Neuroanatomical Substrates for Depression in Bipolar Disorder versus Major Depressive Disorder, CEREBRAL CORTEX, 29(1), 202-214, 201901
  54. Harmonization of resting-state functional MRI data across multiple imaging sites via the separation of site differences into sampling bias and measurement bias, PLOS BIOLOGY, 17(4), 201904
  55. ★, Identification of depression subtypes and relevant brain regions using a data-driven approach, SCIENTIFIC REPORTS, 8, 20180920
  56. ★, Predicting Ventral Striatal Activation During Reward Anticipation From Functional Connectivity at Rest, FRONTIERS IN HUMAN NEUROSCIENCE, 13, 20190827
  57. White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals, MOLECULAR PSYCHIATRY, 25(4), 883-895, 202004
  58. Importance of the Habenula for Avoidance Learning Including Contextual Cues in the Human Brain: A Preliminary fMRI Study, FRONTIERS IN HUMAN NEUROSCIENCE, 14, 20200512
  59. Antidepressive effect of left dorsolateral prefrontal cortex neurofeedback in patients with major depressive disorder: A preliminary report, JOURNAL OF AFFECTIVE DISORDERS, 271, 224-227, 20200615
  60. Enhancing Multi-Center Generalization of Machine Learning-Based Depression Diagnosis From Resting-State fMRI, FRONTIERS IN PSYCHIATRY, 11, 20200528
  61. ★, Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants, SCIENTIFIC REPORTS, 10(1), 20200226
  62. ★, Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis, SCIENTIFIC REPORTS, 10(1), 20201008
  63. ★, Generalizable brain network markers of major depressive disorder across multiple imaging sites, PLOS BIOLOGY, 18(12), 202012
  64. Personality classification enhances blood metabolome analysis and biotyping for major depressive disorders: two-species investigation, JOURNAL OF AFFECTIVE DISORDERS, 279, 20-30, 20210115
  65. ★, White matter abnormalities and cognitive function in euthymic patients with bipolar disorder and major depressive disorder, BRAIN AND BEHAVIOR, 10(12), 202012
  66. ★, Age-related white matter changes revealed by a whole-brain fiber-tracking method in bipolar disorder compared to major depressive disorder and healthy controls, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 75(2), 46-56, 202102
  67. Common Brain Networks Between Major Depressive-Disorder Diagnosis and Symptoms of Depression That Are Validated for Independent Cohorts, FRONTIERS IN PSYCHIATRY, 12, 20210610
  68. Optimized protocol for the extraction of RNA and DNA from frozen whole blood sample stored in a single EDTA tube, SCIENTIFIC REPORTS, 11(1), 20210823
  69. A multi-site, multi-disorder resting-state magnetic resonance image database, SCIENTIFIC DATA, 8(1), 20210830
  70. Brain changes associated with impaired attention function in chronic pain, BRAIN AND COGNITION, 154, 202111
  71. Modeling Heterogeneous Brain Dynamics of Depression and Melancholia Using Energy Landscape Analysis, FRONTIERS IN PSYCHIATRY, 12, 20211125
  72. Resting-state brain activity can predict target-independent aptitude in fMRI-neurofeedback training, NEUROIMAGE, 245, 20211215

Invited Lecture, Oral Presentation, Poster Presentation

  1. fMRI biomarker for major depressive disorder and the treatment response, Okada G, Takamura M, the 6th Asian College of Neuropsychopharmacology, 2019/10/13, Without Invitation, English
  2. Cortisol modulation of emotion regulation neurocircuits in PTSD, Go Okada, Sean T. Ma, S. Shaun Ho, Stephen Taylor, James L. Abelson, Israel Liberzon, 30th CINP World Congress, 2016/07/05, Without Invitation, English
  3. Toward an Understanding of the Neurobiological Basis of Late Life Depression: Brain imaging and Blood Biomarker Study, Okada G, Okamoto Y, Takamura M, Matsumoto T, Yamawaki S, 15th Annual meeting of the International College of Geriatric Psychoneuropharmacolog, 2015/10/08, Without Invitation, English


  1. 2009/11/04, International College of Geriatric Psychoneuropharmacology (ICGP) Junior Investigator Award