Last Updated :2023/12/04

Affiliations, Positions
Hiroshima University Genome Editing Innovation Center, Associate Professor (Special Appointment)
We are promoting the development of the purely domestic genome editing tool "Zinc Finger-ND1".

Basic Information

Major Professional Backgrounds

  • 2023/04/01, Hiroshima University, Genome Editing Innovation Center, Associate Professor
  • 2022/08/01, 2023/03/31, Hiroshima University, Genome Editing Innovation Center, Associate Professor, Collaborative Research Laboratory
  • 2022/05/01, 2022/07/31, Hiroshima University, Genome Editing Innovation Center, Assistant Professor, Collaborative Research Laboratory
  • 2019/05/01, 2022/04/30, AISIN Co.,LTD., Sapporo Institute, Principal Investigator
  • 2018/04/01, 2019/04/30, Tohoku Univeristy, Department of Ophthalmology Graduate School of Medicine, Assistant Professor

Educational Backgrounds

  • Hokkaido University, Graduate School of Medicine, Medicine, Japan, 2015/04, 2018/03

Academic Degrees


Research Fields

  • Biological Sciences;Genome science;System genome science
  • Biological Sciences;Genome science;Medical genome science
  • Complex systems;Biomolecular science;Chemical biology

Research Keywords

  • Zinc Finger-ND1, Genome Editing, Epigenome Editing, In Vivo Genome Editing, Gene Therapy

Affiliated Academic Societies

  • The Japanese Society for Genome Editing

Research Activities

Academic Papers

  1. ★, A CRISPR/Cas9-based method for targeted DNA methylation enables cancer initiation in B lymphocytes, Advanced genetics, 2(1), 2021
  2. ★, Editing of DNA methylation using CRISPR/Cas9 and a ssDNA template in human cells., Biochemical and biophysical research communications, 581, 2021
  3. ★, Single AAV-mediated mutation replacement genome editing in limited number of photoreceptors restores vision in mice., Nature communications, 11(1), 2020
  4. ★, In vivo and in vitro knockout system labelled using fluorescent protein via microhomology-mediated end joining., Life science alliance, 3(1), 2020
  5. Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina., Investigative ophthalmology & visual science, 59(10), 2018
  6. ★, A Powerful CRISPR/Cas9-Based Method for Targeted Transcriptional Activation., Angewandte Chemie (International ed. in English), 55(22), 2016
  7. ★, MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells., Scientific reports, 6, 2016
  8. ★, Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches., Cell stem cell, 16(6), 2015
  9. ★, Loss of ADAR1 in human iPS cells promotes caspase3-mediated apoptotic cell death., Genes to cells : devoted to molecular & cellular mechanisms, 20(8), 2015
  10. Putative roles of bovine colostral odorant-binding protein (bcOBP) for pheromone transport and sexual behavior, Asian journal of agricultural research, 9(6), 2015
  11. Quantification of bovine colostral odorant-binding protein (bcOBP) mRNA distributed in principal organs of bovine body, International journal of dairy science, 10(3), 2015
  12. Localisation of bovine colostral odorant-binding protein (bcOBP) mRNAs in several tissues of bovine body., Cell biology international, 38(3), 2014