Last Updated :2024/07/05

Affiliations, Positions
Hiroshima University Genome Editing Innovation Center, Associate Professor (Special Appointment)
We are promoting the development of the purely domestic genome editing tool "Zinc Finger-ND1".

Basic Information

Major Professional Backgrounds

  • 2023/04/01, Hiroshima University, Genome Editing Innovation Center, Associate Professor
  • 2022/08/01, 2023/03/31, Hiroshima University, Genome Editing Innovation Center, Associate Professor, Collaborative Research Laboratory
  • 2022/05/01, 2022/07/31, Hiroshima University, Genome Editing Innovation Center, Assistant Professor, Collaborative Research Laboratory
  • 2019/05/01, 2022/04/30, AISIN Co.,LTD., Sapporo Institute, Principal Investigator
  • 2018/04/01, 2019/04/30, Tohoku Univeristy, Department of Ophthalmology Graduate School of Medicine, Assistant Professor

Educational Backgrounds

  • Hokkaido University, Graduate School of Medicine, Medicine, Japan, 2015/04, 2018/03

Academic Degrees


Research Fields

  • Biological Sciences;Genome science;System genome science
  • Biological Sciences;Genome science;Medical genome science
  • Complex systems;Biomolecular science;Chemical biology

Research Keywords

  • Zinc Finger-ND1, Genome Editing, Epigenome Editing, In Vivo Genome Editing, Gene Therapy

Affiliated Academic Societies

  • The Japanese Society for Genome Editing

Educational Activity

Course in Charge

  1. 2024, Graduate Education (Master's Program) , Second Semester, Clinical Applications of Genome Editing Technology

Research Activities

Academic Papers

  1. ★, Engineering of Zinc Finger Nucleases Through Structural Modeling Improves Genome Editing Efficiency in Cells, Advanced Science, 11(23), 202406
  2. A more efficient method for generating glioblastoma-multiforme model in mice using genome editing technology, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 702, 202404
  3. A CRISPR/Cas9-based method for targeted DNA methylation enables cancer initiation in B lymphocytes, Advanced genetics, 2(1), 2021
  4. Editing of DNA methylation using CRISPR/Cas9 and a ssDNA template in human cells., Biochemical and biophysical research communications, 581, 2021
  5. ★, Single AAV-mediated mutation replacement genome editing in limited number of photoreceptors restores vision in mice., Nature communications, 11(1), 2020
  6. ★, In vivo and in vitro knockout system labelled using fluorescent protein via microhomology-mediated end joining., Life science alliance, 3(1), 2020
  7. Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina., Investigative ophthalmology & visual science, 59(10), 2018
  8. ★, A Powerful CRISPR/Cas9-Based Method for Targeted Transcriptional Activation., Angewandte Chemie (International ed. in English), 55(22), 2016
  9. MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells., Scientific reports, 6, 2016
  10. Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches., Cell stem cell, 16(6), 2015
  11. Loss of ADAR1 in human iPS cells promotes caspase3-mediated apoptotic cell death., Genes to cells : devoted to molecular & cellular mechanisms, 20(8), 2015
  12. Putative roles of bovine colostral odorant-binding protein (bcOBP) for pheromone transport and sexual behavior, Asian journal of agricultural research, 9(6), 2015
  13. Quantification of bovine colostral odorant-binding protein (bcOBP) mRNA distributed in principal organs of bovine body, International journal of dairy science, 10(3), 2015
  14. Localisation of bovine colostral odorant-binding protein (bcOBP) mRNAs in several tissues of bovine body., Cell biology international, 38(3), 2014