Yusuke Sotomaru
Last Updated :2023/06/01
- Affiliations, Positions
- Natural Science Center for Basic Research and Development, Professor
- Web Site
- E-mail
- sotomaru
hiroshima-u.ac.jp
- Self-introduction
- Studies on reproductive developmental engineering technologies in mammals, especially in experimental and domestic animals: Development of animal cloning system using a micromanipulation and nuclear transfer techniques, and investigation of developmental mechanism in the early stage embryos
Basic Information
Major Professional Backgrounds
- 1995/04/01, 1996/03/30, CLEA Japan, Inc.
- 1998/04/01, 1999/03/31, Kinki University, Research Associate
- 2001/04/01, 2004/03/31, Central Institute for Experimental Animals, Researcher
- 2004/04/01, 2005/02/15, Central Institute for Experimental Animals, Office Director
- 2005/02/16, 2007/03/31, Hiroshima University, Natural Science Center for Basic Research and Development, Associate Professor
- 2007/04/01, 2011/03/31, Hiroshima University, Natural Science Center for Basic Research and Development, Associate Professor
- 2011/04/01, Hiroshima University, Natural Science Center for Basic Research and Development, Professor
- 2013/04/01, Hiroshima University, Vice Director, Natural Science Center for Basic Research and Development
Educational Backgrounds
- Kinki University, Graduate School, Division of Agricultural Science, Japan, 1996/04, 1998/03
- Tokyo University of Agriculture, Graduate School, Division of Agriculture, Animal Science, Japan, 1991/04, 1993/03
- Tokyo University of Agriculture, Faculty of Agriculture, Japan, 1987/04, 1991/03
Academic Degrees
- Doctor of Philosophy, Tokyo University of Agriculture
- Master, Tokyo University of Agriculture
Educational Activity
- [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine
Research Fields
- Biological Sciences;Laboratory animal science;Laboratory animal science
Affiliated Academic Societies
- Japan Society for Ova Research
Educational Activity
Course in Charge
- 2023, Liberal Arts Education Program1, 1Term, Ethics and regulations in natural science research
- 2023, Graduate Education (Master's Program) , First Semester, Seminar
- 2023, Graduate Education (Master's Program) , Second Semester, Seminar
- 2023, Graduate Education (Master's Program) , First Semester, Research
- 2023, Graduate Education (Master's Program) , Second Semester, Research
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
- 2023, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
- 2023, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Life Science
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Life Science
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Life Science
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Life Science
- 2023, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science
Research Activities
Academic Papers
- Gene Targeting and Subsequent Site-Specific Transgenesis at the beta-actin (ACTB) Locus in Common Marmoset Embryonic Stem Cells, STEM CELLS AND DEVELOPMENT, 20(9), 1588-1600, 201109
- Incisor Enamel Formation is Impaired in Transgenic Rats Overexpressing the Type III NaPi Transporter Slc20a1, CALCIFIED TISSUE INTERNATIONAL, 89(3), 192-202, 201109
- Protocol for the production of viable bimaternal mouse embryos, NATURE PROTOCOLS, 3(2), 197-209, 2008
- Identification of genes aberrantly expressed in mouse embryonic stem cell-cloned blastocysts, BIOLOGY OF REPRODUCTION, 78(4), 568-576, 200804
- Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts, EXPERIMENTAL LUNG RESEARCH, 34(7), 373-390, 2008
- Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice, HUMAN MOLECULAR GENETICS, 18(10), 1879-1888, 20090515
- Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 2, GENOMICS, 93(5), 461-472, 200905
- Generation of transgenic non-human primates with germline transmission, NATURE, 459(7246), 523-U50, 20090528
- Developmental Ability of Trophoblast Stem Cells in Uniparental Mouse Embryos, PLACENTA, 30(5), 448-456, 200905
- Preimplantation Development of Somatic Cell Cloned Embryos in the Common Marmoset (Callithrix jacchus), CLONING AND STEM CELLS, 11(4), 575-583, 200912
- Identification of Inappropriately Reprogrammed Genes by Large-Scale Transcriptome Analysis of Individual Cloned Mouse Blastocysts, PLOS ONE, 5(6), 20100630
- Contribution of Intragenic DNA Methylation in Mouse Gametic DNA Methylomes to Establish Oocyte-Specific Heritable Marks, PLOS GENETICS, 8(1), 201201
- Neoplastic transformation by TERT in FGF-2-expanded human mesenchymal stem cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 39(1), 5-11, 201107
- Establishment of ES Cells from Inbred Strain Mice by Dual Inhibition (2i), JOURNAL OF REPRODUCTION AND DEVELOPMENT, 58(1), 77-83, 201202
- Development of Lymphoproliferative Diseases by Hypoxia Inducible Factor-1alpha Is Associated with Prolonged Lymphocyte Survival, PLOS ONE, 8(4), 20130412
- Long-term serial cultivation of mouse induced pluripotent stem cells in serum-free and feeder-free defined medium, INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 57(9-10), 715-724, 2013
- Characterization of common marmoset (Callithrix jacchus) bone marrow-derived mesenchymal stem cells, FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, 51(4), 292-299, 2013
- A study on cryoprotectant solution suitable for vitrification of rat two-cell stage embryos, CRYOBIOLOGY, 68(1), 147-151, 201402
- Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli, NEUROBIOLOGY OF DISEASE, 68, 215-227, 201408
- Dynamics of genomic 5-hydroxymethylcytosine during mouse oocyte growth, GENES TO CELLS, 19(8), 629-636, 201408
- Chlorinated Water Modulates the Development of Colorectal Tumors with Chromosomal Instability and Gut Microbiota in Apc-Deficient Mice, PLOS ONE, 10(7), 20150717
- Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation of IFN-gamma production in iNKT cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(24), E3394-E3402, 20160614
- KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer, ONCOGENESIS, 5, 201608
- Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor beta Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation, PLOS ONE, 11(11), 20161111
- Quality of common marmoset (Callithrix jacchus) oocytes collected after ovarian stimulation, THERIOGENOLOGY, 106, 221-226, 20180115
- The Role of Cysteine String Protein alpha Phosphorylation at Serine 10 and 34 by Protein Kinase C gamma for Presynaptic Maintenance, JOURNAL OF NEUROSCIENCE, 38(2), 278-290, 20180110
- Transgenic mice specifically expressing amphiregulin in white adipose tissue showed less adipose tissue mass, GENES TO CELLS, 23(3), 136-145, 201803
- Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice, HUMAN MOLECULAR GENETICS, 26(19), 3653-3662, 20171001
- XY oocytes of sex-reversed females with a Sry mutation deviate from the normal developmental process beyond the mitotic stage., Biol Reprod., 201810
- Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages., Immunology., 130(2), 243-253, 20100119
- Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure, NUTRITION & METABOLISM, 16, 20190704
- Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model, PLOS ONE, 14(6), 20190626
- The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment, SCIENTIFIC REPORTS, 9, 20191001
- The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice, COMMUNICATIONS BIOLOGY, 3(1), 20200116
- Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction, CLINICAL CANCER RESEARCH, 26(8), 2065-2079, 202004
- Optineurin regulates osteoblastogenesis through STAT1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(4), 889-894, 20200514
Invited Lecture, Oral Presentation, Poster Presentation
- Stepwise differentiation of ScxGFP iPS cells into mature tenocytes and ligamentocytes, 2019/12/03, Without Invitation, Japanese
- Effect of cetrorelix acetate administration on ovarian stimulation in aged mice., Sotomaru Y, Sotomaru Y, Kanda A, Kanzaki M., 14th FELASA Congress, 2019/06/10, Without Invitation, English, FELASA, Prague, Czech Republic
- A mutation of the spinocerebellar ataxia gene CACNA1G induces cerebellar Purkinje cell death and ataxia in mice., Y. Matsuda, Y. Matsuda, H. Morino, T. Kurashige, T. Matsuoka, Y. Sotomaru, K. Hashimoto, and H. Kawakami., SFN2017, 2017/11/11, Without Invitation, English
- Techniques for creating genetically identical animalsin the non-human primates., Yusuke Sotomaru, 2017 Asia-Oceania Regional Meeting for Marmoset Research, 2017/03/16, With Invitation, English, Seoul, Korea
- Characterization of common marmoset (Callithrix jacchus) bone marrow-derived cells., Akifumi Kanda, Akifumi Kanda, Seiji Shiozawa, Asako Nobukiyo, Teruhiko Hatakeyama, Emi Yamaoka, Eiso Hiyama, Yusuke Sotomaru, International Society for Stem Cell Research, 2012/06/14, Without Invitation, English, International Society for Stem Cell Research, Yokohama
- Effect of Donor-cell type on developmental potential of clone embryos in the common marmosets, Sotomaru Y, Sotomaru Y, Yoshioka M, Nobukiyo A, Sasaki E., Marmoset –Frontiers in Biomedical Researches on Marmosets as a Primate Model, 2012/02/21, Without Invitation, English, Tokyo
- Use of an adhesion barrier for preventing postoperative adhesion in common marmosets that underwent oocyte collection, Hatakayama T, Hatakayama T, Nobukiyo A, Nishimoto H, Nojiri T, Yoshioka M, Sotomaru Y., Marmoset –Frontiers in Biomedical Researches on Marmosets as a Primate Model, 2012/02/21, Without Invitation, English, Japan Society for Marmoset Reseach, Tokyo
- Application of ES/somatic cell cloning technique to the production of genetically modified marmoset., Sotomaru Y, Sotomaru Y, Sasaki E, Okano H., The 34th Annual Meeting of the Japan Neuroscience Society, 2011/09/17, With Invitation, English, Annual Meeting of the Japan Neuroscience Society, Yokohama
- Establishment of ES cells of inbred strain mice by dual inhibition (2i), 2010/12/10, Without Invitation, Japanese
- Whole genome bisulphate shotgun sequencing in mouse germ cells, Kobayashi H, Kobayashi H, Sakurai T, Takahashi N, Obata Y, Nakabayashi K, Hata K, Sotomamru Y, Suzuki Y, Kono T, International Symposium on “Epigenome Network, Development and Reprogramming of Germ Cells”, 2010/11/24, Without Invitation, English, “Epigenome Network, Development and Reprogramming of Germ Cells”, Fukuoka
External Funds
Acceptance Results of Competitive Funds
- 2018/04/03, 2020
- Strategic Research Programs for Brain Science(ACT-C), 2017/04/01, 2018/03/31
- 2017/03/30, 2019
- Strategic Research Program for Brain Sciences , 2016/04/01, 2017/03/31
- 2016, 2018
- Strategic Research Program for Brain Sciences, 2015/04/01, 2016/03/31
- KAKENHI, 2015, 2018
- KAKENHI, 2015, 2018
- KAKENHI, 2015
- Strategic Research Programs for Brain Science(ACT-C), 2014/04/01, 2015/03/31
- KAKENHI, 2013, 2014
- KAKENHI, 2013, 2015
- KAKENHI, 2012, 2014
- KAKENHI, 2010, 2014
- KAKENHI, Establishment of the novel mouse model of metastatic colorectalcancer and identification of the biomarker for tissue-specific metastasis, 2010, 2013
- KAKENHI, Molecular analysis for developing the newtargeting therapy in Japanese Pediatric Liver Tumor study group, 2010, 2012
- KAKENHI, 2010, 2010
- KAKENHI, Elucidation of development mechanism and molecular targets in neuroblastoma and hepatoblastoma using genomics and cellomics, 2009, 2011
- 2008, 2012
- KAKENHI, 2007, 2008
- KAKENHI, Regulation of germ line function and development by genomic imprinting, 2006, 2008
- KAKENHI, Establishment of preclinical study system for regenerative medicine using somatic nuclear transferred embryonic stem cells, 2006, 2007
- KAKENHI, 2004, 2005
- KAKENHI, Studies on developmental aberration of somatic clones by global gene expression analysis, 2004, 2005
- KAKENHI, Basic studies on animal model for regenerative medicine using severe immunodeficient mice., 2003, 2004
- KAKENHI, Development of genetic and microbiological quality control system of mouse embryonic stem cell lines., 2003, 2005