TAKAHIRO MIMAE

Last Updated :2025/05/09

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Assistant Professor
E-mail
tmimae＠hiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2012/04/01, 2012/08/31, Hiroshima University Hospital, Clinical Fellow
  • 2012/09/01, 2015/03/31, Hiroshima University, Research Institute for Radiation Biology and Medicine, Research Center for Radiation Casualty Medicine, Assistant Professor
  • 2015/04, 2018/03, Memorial Sloan Kettering Cancer Center, Research Fellow
  • 2018/04/01, 2022/03/31, Hiroshima University, Hospital, Assistant Professor

Educational Backgrounds

  • Hiroshima University, Japan, 2008/04, 2012/03
  • Hiroshima University, Japan, 1997/04, 2003/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Respiratory surgery

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Intensive, Introduction to clinical clerkship
  2. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  3. 2025, Undergraduate Education, Intensive, Practice of Medicine II
  4. 2025, Undergraduate Education, First Semester, Surgery I

Research Activities

Academic Papers

  1. Prediction of Unexpected N2 Disease Associated With Clinical T1-2N0-1M0 Non-Small-Cell Lung Cancer., Clinical lung cancer, 22(2), 2021
  2. ASO Author Reflections: Is Wedge Resection Optimal for Octogenarians with Early-Stage Non-Small-Cell Lung Cancer Compared with Lobectomy/Segmentectomy?, Annals of surgical oncology, 28(12), 2021
  3. Survival of Octogenarians with Early-Stage Non-small Cell Lung Cancer is Comparable Between Wedge Resection and Lobectomy/Segmentectomy: JACS1303., Annals of surgical oncology, 28(12), 2021
  4. Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients., Scientific reports, 11(1), 2021
  5. Prognostic role of interstitial pneumonia with or without emphysema in patients with clinical stage I lung cancer., Japanese journal of clinical oncology, 51(7), 2021
  6. Complex Segmentectomy for Hypermetabolic Clinical Stage IA Non-Small Cell Lung Cancer., The Annals of thoracic surgery, 113(4), 2022
  7. Serum S100 calcium-binding protein A4 as a novel predictive marker of acute exacerbation of interstitial pneumonia after surgery for lung cancer., BMC pulmonary medicine, 21(1), 2021
  8. The impact of pathological lymph node metastasis with lymphatic invasion on the survival of patients with clinically node-negative non-small cell lung cancer: A multicenter study., Lung cancer (Amsterdam, Netherlands), 158, 2021
  9. Role of Soluble Receptor for Advanced Glycation End Products in Postoperative Fibrotic Lung Injury., The Annals of thoracic surgery, 113(5), 2022
  10. Systematic Versus Lobe-Specific Mediastinal Lymphadenectomy for Hypermetabolic Lung Cancer., Annals of surgical oncology, 28(12), 2021
  11. Postoperative Pulmonary Function After Complex Segmentectomy., Annals of surgical oncology, 28(13), 2021
  12. Utility of Newly Proposed Grading System From International Association for the Study of Lung Cancer for Invasive Lung Adenocarcinoma., JTO clinical and research reports, 2(2), 2021
  13. Segmentectomy versus lobectomy for solid predominant cN0 lung cancer: analysis using visual evaluation of positron emission tomography., European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 61(2), 2022
  14. Segmentectomy versus wedge resection for radiological solid predominant and low metabolic non-small cell lung cancer., Interactive cardiovascular and thoracic surgery, 34(5), 2022
  15. Interstitial pneumonia and advanced age negatively influence postoperative pulmonary function., Interactive cardiovascular and thoracic surgery, 34(5), 2022
  16. Oncological outcome of segmentectomy for early-stage non-small-cell lung cancer with invasive characteristics: a multicentre study., European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 62(2), 2022
  17. The prognostic impact of the ground-glass opacity component in nearly pure-solid stage IA non-small-cell lung cancer., European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2022
  18. Commentary: Segmentectomy as a standard surgery, a new era in small sized, peripheral, non-small cell lung cancer., JTCVS techniques, 12, 2022
  19. A Multicenter Study of Complex Segmentectomy Versus Wedge Resection in Clinical Stage 0-IA Non-Small Cell Lung Cancer., Clinical lung cancer, 23(5), 2022
  20. Psychological states regarding adjuvant chemotherapy in patients with non-small cell lung cancer., Cancer treatment and research communications, 32, 2022
  21. Complications and Survival After Lung Cancer Resection in Interstitial Lung Disease., The Annals of thoracic surgery, 2022
  22. Possible Therapeutic Utility of anti-Cell Adhesion Molecule 1 Antibodies for Malignant Pleural Mesothelioma., Frontiers in cell and developmental biology, 10, 2022
  23. Complex Segmentectomy for Hypermetabolic Clinical Stage IA Non-Small Cell Lung Cancer, ANNALS OF THORACIC SURGERY, 113(4), 1317-1324, 202204
    Link to Paper Search Results by DOI
  24. ASO Author Reflections: Is Wedge Resection Optimal for Octogenarians with Early-Stage Non-Small-Cell Lung Cancer Compared with Lobectomy/Segmentectomy?, ANNALS OF SURGICAL ONCOLOGY, 28(12), 7228-7229, 202111
    Link to Paper Search Results by DOI
  25. Role of Soluble Receptor for Advanced Glycation End Products in Postoperative Fibrotic Lung Injury, ANNALS OF THORACIC SURGERY, 113(5), 1617-1623, 202205
    Link to Paper Search Results by DOI
  26. Interstitial pneumonia and advanced age negatively influence postoperative pulmonary function, INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 34(5), 753-759, 20220502
    Link to Paper Search Results by DOI
  27. Segmentectomy versus wedge resection for radiological solid predominant and low metabolic non-small cell lung cancer, INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 34(5), 814-821, 20220502
    Link to Paper Search Results by DOI
  28. Segmentectomy versus lobectomy for solid predominant cN0 lung cancer: analysis using visual evaluation of positron emission tomography, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 61(2), 279-286, 20220124
    Link to Paper Search Results by DOI
  29. Upregulation of Notch2 and Six1 Is Associated with Progression of Early- Stage Lung Adenocarcinoma and a More Aggressive Phenotype at Advanced Stages, CLINICAL CANCER RESEARCH, 18(4), 945-955, 20120215
    Link to Paper Search Results by DOI
  30. Novel application for pseudopodia proteomics using excimer laser ablation and two-dimensional difference gel electrophoresis, LABORATORY INVESTIGATION, 92(9), 1374-1385, 201209
    Link to Paper Search Results by DOI
  31. Cathepsin D as a potential prognostic marker for lung adenocarcinoma, PATHOLOGY RESEARCH AND PRACTICE, 208(9), 534-540, 2012
    Link to Paper Search Results by DOI
  32. Protein expression and gene copy number changes of receptor tyrosine kinase in thymomas and thymic carcinomas, ANNALS OF ONCOLOGY, 23(12), 3129-3137, 201212
    Link to Paper Search Results by DOI
  33. The prognostic role of pathologic invasive component size, excluding lepidic growth, in stage I lung adenocarcinoma, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 146(3), 580-585, 201309
    Link to Paper Search Results by DOI
  34. Increased ectodomain shedding of lung epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema, THORAX, 69(3), 223-231, 201403
    Link to Paper Search Results by DOI
  35. alpha-Parvin, a pseudopodial constituent, promotes cell motility and is associated with lymph node metastasis of lobular breast carcinoma, BREAST CANCER RESEARCH AND TREATMENT, 144(1), 59-69, 201402
    Link to Paper Search Results by DOI
  36. Role of lymphatic invasion in the prognosis of patients with clinical node-negative and pathologic node-positive lung adenocarcinoma, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 147(6), 1820-1826, 201406
    Link to Paper Search Results by DOI
  37. Prediction for prognosis of resected pT1a-lbN0M0 adenocarcinoma based on tumor size and histological status: Relationship of TNM and IASLC/ATS/ERS classifications, LUNG CANCER, 85(2), 270-275, 201408
    Link to Paper Search Results by DOI
  38. Role of Positron Emission Tomography/Computed Tomography Findings for Adjuvant Chemotherapy Indications in Stage T1b-2aN0M0 Lung Adenocarcinoma, ANNALS OF THORACIC SURGERY, 98(2), 417-423, 201408
    Link to Paper Search Results by DOI
  39. Prognosis of Lung Cancer Patients with a Past History of Colorectal Cancer, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 44(11), 1088-1095, 201411
    Link to Paper Search Results by DOI
  40. CLINICOPATHOLOGICAL EVALUATION OF NEO-ADJUVANT CHEMOTHERAPY WITH PACLITAXEL FOLLOWED BY FEC FOR LOCALLY ADVANCED BREAST CANCER, 66(5), 990-994, 20050525
  41. A CASE REPORT OF PANCREATIC NEUROENDOCRINE CARCINOMA PRESENTED WITH HEMORRHAGE FROM THE VARICOSE VEIN OF THE STOMACH, 69(8), 2108-2113, 20080825
  42. Clinical Study of Roux Stasis Syndrome after Distal Gastrectomy, The Japanese journal of gastroenterological surgery, 41(8), 1551-1556, 20080801
  43. Evaluation of resected indeterminate tumors : The influence of CT screening on clinical diagnosis, Jpn J Chest Surg, 22(7), 992-996, 20081115
  44. CLINICOPATHOLOGICAL EVALUATION OF NEO-ADJUVANT CHEMOTHERAPY WITH PACLITAXEL FOLLOWED BY FEC FOR LOCALLY ADVANCED BREAST CANCER, Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 66(5), 990-994, 2005
  45. Clinical Study of Roux Stasis Syndrome after Distal Gastrectomy, The Japanese Journal of Gastroenterological Surgery, 41(8), 1551-1556, 2008
  46. A CASE REPORT OF PANCREATIC NEUROENDOCRINE CARCINOMA PRESENTED WITH HEMORRHAGE FROM THE VARICOSE VEIN OF THE STOMACH, Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 69(8), 2108-2113, 2008
  47. [A clinical study of endoscopic local coagulation therapy for hepatocellular carcinoma (HCC)]., Gan to kagaku ryoho. Cancer & chemotherapy, 32(11), 2005
  48. [A case of recurrent gastric cancer with improvement of obstructive symptoms caused by carcinomatous peritonitis and prolonged survival by chemotherapy with combined use of Paclitaxel and 5-FU]., Gan to kagaku ryoho. Cancer & chemotherapy, 33(2), 2006
  49. Esophagectomy via left thoracotomy for esophageal cancer with situs inversus totalis: report of a case., Surgery today, 38(11), 2008
  50. Advantage of absorbable suture material for pulmonary artery ligation., General thoracic and cardiovascular surgery, 58(10), 2010
  51. Upregulation of notch2 and six1 is associated with progression of early-stage lung adenocarcinoma and a more aggressive phenotype at advanced stages., Clinical cancer research : an official journal of the American Association for Cancer Research, 18(4), 2012
  52. c-MET/phospho-MET protein expression and MET gene copy number in non-small cell lung carcinomas., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 7(2), 2012
  53. Novel application for pseudopodia proteomics using excimer laser ablation and two-dimensional difference gel electrophoresis., Laboratory investigation; a journal of technical methods and pathology, 92(9), 2012
  54. Cathepsin D as a potential prognostic marker for lung adenocarcinoma., Pathology, research and practice, 208(9), 2012
  55. Increased ectodomain shedding of lung epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema., Thorax, 69(3), 2014
  56. α-Parvin, a pseudopodial constituent, promotes cell motility and is associated with lymph node metastasis of lobular breast carcinoma., Breast cancer research and treatment, 144(1), 2014
  57. Role of lymphatic invasion in the prognosis of patients with clinical node-negative and pathologic node-positive lung adenocarcinoma., The Journal of thoracic and cardiovascular surgery, 147(6), 2014
  58. Segmentectomy versus lobectomy for clinical stage IA lung adenocarcinoma., Annals of cardiothoracic surgery, 3(2), 2014
  59. Role of positron emission tomography/computed tomography findings for adjuvant chemotherapy indications in stage T1b-2aN0M0 lung adenocarcinoma., The Annals of thoracic surgery, 98(2), 2014
  60. Prediction for prognosis of resected pT1a-1bN0M0 adenocarcinoma based on tumor size and histological status: relationship of TNM and IASLC/ATS/ERS classifications., Lung cancer (Amsterdam, Netherlands), 85(2), 2014
  61. Surgical outcomes of non-small-cell lung carcinoma in patients previously treated for gastric cancer., European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47(4), 2015
  62. Prognosis of lung cancer patients with a past history of colorectal cancer., Japanese journal of clinical oncology, 44(11), 2014
  63. Reply to the editor., The Journal of thoracic and cardiovascular surgery, 148(4), 2014
  64. A novel approach to pseudopodia proteomics: excimer laser etching, two-dimensional difference gel electrophoresis, and confocal imaging., Protocol exchange, 2014, 2014
  65. New challenges in pseudopodial proteomics by a laser-assisted cell etching technique., Biochimica et biophysica acta, 1854(6), 2015
  66. Comparison of malignant grade between pure and partially invasive types of early lung adenocarcinoma., The Annals of thoracic surgery, 99(3), 2015
  67. What are the radiologic findings predictive of indolent lung adenocarcinoma?, Japanese journal of clinical oncology, 45(4), 2015
  68. Histologic changes associated with the use of fibrinogen- and thrombin-impregnated collagen in the prevention of pulmonary air leakage., The Journal of thoracic and cardiovascular surgery, 149(4), 2015
  69. Negative prognostic influence of micropapillary pattern in stage IA lung adenocarcinoma., European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 49(1), 2016
  70. Surgical Outcomes of Lung Cancer in Patients with Combined Pulmonary Fibrosis and Emphysema., Annals of surgical oncology, 22 Suppl 3, 2015
  71. Radiologic findings to predict low-grade malignant tumour among clinical T1bN0 lung adenocarcinomas: lessons from histological subtypes., Japanese journal of clinical oncology, 45(8), 2015
  72. Increased ectodomain shedding of cell adhesion molecule 1 as a cause of type II alveolar epithelial cell apoptosis in patients with idiopathic interstitial pneumonia., Respiratory research, 16, 2015
  73. The intracellular domain of cell adhesion molecule 1 is present in emphysematous lungs and induces lung epithelial cell apoptosis., Journal of biomedical science, 22, 2015
  74. The Difference in Maximum Standardized Uptake Value among Lung Adenocarcinomas Located at the Upper and Lower Zone on PET/CT., Respiration; international review of thoracic diseases, 90(4), 2015
  75. Impact of Lepidic Component Occupancy on Effects of Adjuvant Chemotherapy for Lung Adenocarcinoma., The Annals of thoracic surgery, 100(6), 2015
  76. Prognostic value of the new IASLC/ATS/ERS classification of clinical stage IA lung adenocarcinoma., Lung cancer (Amsterdam, Netherlands), 90(2), 2015
  77. Association between [18F]-fluoro-2-deoxyglucose uptake and expressions of hypoxia-induced factor 1α and glucose transporter 1 in non-small cell lung cancer., Japanese journal of clinical oncology, 45(12), 2015
  78. Application of Lepidic Component Predominance to Adjuvant Chemotherapy with Oral Fluoropyrimidines for Stage I Lung Adenocarcinoma., Clinical lung cancer, 17(5), 2016
  79. Prognostic Role of Subtype Classification in Small-Sized Pathologic N0 Invasive Lung Adenocarcinoma., The Annals of thoracic surgery, 102(5), 2016
  80. Severity of lung fibrosis affects early surgical outcomes of lung cancer among patients with combined pulmonary fibrosis and emphysema., Medicine, 95(29), 2016
  81. Feasibility and efficacy of salvage lung resection after definitive chemoradiation therapy for Stage III non-small-cell lung cancer., Interactive cardiovascular and thoracic surgery, 23(6), 2016
  82. Prognostic significance of vascular invasion in intermediate-grade subtype of lung adenocarcinoma., Japanese journal of clinical oncology, 2016
  83. Integrin-α10 Dependency Identifies RAC and RICTOR as Therapeutic Targets in High-Grade Myxofibrosarcoma., Cancer discovery, 6(10), 2016
  84. Is cancer history really an exclusion criterion for clinical trial of lung cancer? Influence of gastrointestinal tract cancer history on the outcomes of lung cancer surgery., Japanese journal of clinical oncology, 47(2), 2017
  85. Is cancer history really an exclusion criterion for clinical trial of lung cancer? Influence of gastrointestinal tract cancer history on the outcomes of lung cancer surgery., Japanese journal of clinical oncology, 47(2), 2017
  86. Large cell neuroendocrine carcinoma of the lung, The Japanese journal of thoracic surgery, 62(6), 442-445, 200906
  87. [Correlations between hormonal receptor and HER2 status or nuclear grades and response rate in breast cancer treated with neoadjuvant chemotherapy of docetaxel alone]., Gan to kagaku ryoho. Cancer & chemotherapy, 36(4), 2009
  88. Steroid receptor expression in thymomas and thymic carcinomas., Cancer, 117(19), 2011
  89. Insulin-like growth factor-1 receptor protein expression and gene copy number alterations in non-small cell lung carcinomas., Human pathology, 44(6), 2013
  90. The prognostic role of pathologic invasive component size, excluding lepidic growth, in stage I lung adenocarcinoma., The Journal of thoracic and cardiovascular surgery, 146(3), 2013

External Funds

Acceptance Results of Competitive Funds

  1. 2018
  2. 2018