RYUJI TERAYAMA
Last Updated :2025/04/03
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Professor
- Web Site
- E-mail
- ryujit
hiroshima-u.ac.jp
- Self-introduction
- I am primarily involved in gross anatomy, particularly focused on the orofacial structures. We are trying to clarify the mechanisms underlying the development of neuropathic pain and to find appropriate treatments.
Basic Information
Academic Degrees
- Ph.D (Medical Sciences), Miyazaki Medical College
Educational Activity
- [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences
In Charge of Primary Major Programs
Research Fields
- Medicine,dentistry, and pharmacy;Boundary medicine;Pain science
- Biological Sciences;Neuroscience;Nerve anatomy / Neuropathology
- Medicine,dentistry, and pharmacy;Basic medicine;General anatomy (including histology / embryology)
Research Keywords
- Glial cells
- Central nervous system
- Neuropathic pain
Affiliated Academic Societies
- Japanese Association for Oral Biology
- The Japanese Association of Anatomists
- The Japan Neuroscience Society
- Society for Neuroscience
Educational Activity
Course in Charge
- 2025, Undergraduate Education, 2Term, Gross Anatomy
- 2025, Undergraduate Education, 4Term, Life Science
- 2025, Undergraduate Education, 3Term, Topographic Anatomy I
- 2025, Undergraduate Education, 4Term, Topographic Anatomy II
- 2025, Undergraduate Education, 3Term, Basic Practice of Anatomy I
- 2025, Undergraduate Education, 4Term, Basic Practice of Anatomy II
- 2025, Undergraduate Education, 2Term, Embryology
- 2025, Undergraduate Education, 1Term, Histology and Oral Histology
- 2025, Undergraduate Education, 1Term, Basic Practice of Histology I
- 2025, Undergraduate Education, 2Term, Basic Practice of Histology II
- 2025, Undergraduate Education, 2Term, Topics in Dental Research II
- 2025, Undergraduate Education, 3Term, Stomatognathic Function
- 2025, Undergraduate Education, First Semester, Dental Research Practices I
- 2025, Undergraduate Education, 3Term, Clinical Anatomy for Dentistry I
- 2025, Undergraduate Education, 4Term, Clinical Anatomy for Dentistry II
- 2025, Undergraduate Education, 3Term, Practice of Clinical Anatomy for Dentistry I
- 2025, Undergraduate Education, 4Term, Practice of Clinical Anatomy for Dentistry II
- 2025, Undergraduate Education, Second Semester, Dental Research Practices II
- 2025, Undergraduate Education, 2Term, Basic and Clinical Integrated Theory
- 2025, Undergraduate Education, First Semester, Dental Research Practices III
- 2025, Undergraduate Education, 2Term, Anatomy and Oral Anatomy
- 2025, Undergraduate Education, 2Term, Anatomy and Oral Anatomy
- 2025, Graduate Education (Master's Program) , First Semester, Seminar
- 2025, Graduate Education (Master's Program) , Second Semester, Seminar
- 2025, Graduate Education (Master's Program) , First Semester, Research
- 2025, Graduate Education (Master's Program) , Second Semester, Research
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
- 2025, Graduate Education (Master's Program) , First Semester, Human Anatomy
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Oral Biology
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Oral Biology
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Oral Biology
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Oral Biology
Research Activities
Academic Papers
- Inhibition of skeletal muscle differentiation by calciprotein particles in human primary myoblasts, BIOMEDICAL RESEARCH-TOKYO, 45(4), 173-177, 2024
- Effects of Peripheral Nerve Injury on the Induction of c-Fos and Phosphorylated ERK in the Brainstem Trigeminal Sensory Nuclear Complex, Annals of Neurosciences, 30(3), 177-187, 202307
- Mouse maternal odontogenic infection with Porphyromonas gingivalis induces cognitive decline in offspring, FRONTIERS IN PEDIATRICS, 11, 20230811
- High-frequency near-infrared semiconductor laser irradiation suppressed experimental tooth movement-induced inflammatory pain markers in the periodontal ligament tissues of rats, LASERS IN MEDICAL SCIENCE, 38(1), 20230420
- Reorganization of synaptic inputs to spinal dorsal horn neurons in neuropathic pain, INTERNATIONAL JOURNAL OF NEUROSCIENCE, 132(12), 1210-1216, 20221202
- Effects of high-frequency near infrared laser irradiation on experimental tooth movement-induced pain in rats, LASERS IN MEDICAL SCIENCE, 37(6), 2697-2706, 202208
- Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins., The Journal of biological chemistry, 282(8), 2007
- Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue., Brain research, 1129(1), 2007
- Implications of protease M/neurosin in myelination during experimental demyelination and remyelination., Neuroscience letters, 405(3), 2006
- Aspartate-immunoreactive primary sensory neurons in the mouse trigeminal ganglion., Brain research, 1082(1), 2006
- ASIC3-immunoreactive neurons in the rat vagal and glossopharyngeal sensory ganglia., Brain research, 1081(1), 2006
- Brain-derived neurotrophic factor-immunoreactive primary sensory neurons in the rat trigeminal ganglion and trigeminal sensory nuclei., Brain research, 1081(1), 2006
- Activation of the caspase cascade underlies the rat trigeminal primary neuronal apoptosis induced by neonatal capsaicin administration., Archives of histology and cytology, 68(4), 2005
- Regeneration of the abdominal postganglionic sympathetic system., Neuroscience research, 54(4), 2006
- Immunohistochemical localization of gamma and beta subunits of epithelial Na+ channel in the rat molar tooth pulp., Brain research, 1065(1-2), 2005
- Calretinin-containing neurons which co-express parvalbumin and calbindin D-28k in the rat spinal and cranial sensory ganglia; triple immunofluorescence study., Brain research, 1061(2), 2005
- Involvement of neuropsin in the pathogenesis of experimental autoimmune encephalomyelitis., Glia, 52(2), 2005
- Differential expression of protease M/neurosin in oligodendrocytes and their progenitors in an animal model of multiple sclerosis., Neuroscience letters, 382(1-2), 82-87, 20050411
- Differential expression of neuropsin and protease M/neurosin in oligodendrocytes after injury to the spinal cord., Glia, 48(2), 2004
- Local infusion of nerve growth factor attenuates myelinated nerve fiber sprouting into lamina II of the spinal dorsal horn and reduces the increased responsiveness to mechanical stimuli in rats with chronic constriction nerve injury., Journal of anesthesia, 15(4), 2001
- Differential rostral projections of caudal brainstem neurons receiving trigeminal input after masseter inflammation., The Journal of comparative neurology, 465(2), 2003
- Differential effects of NMDA and AMPA/KA receptor antagonists on c-Fos or Zif/268 expression in the rat spinal dorsal horn induced by noxious thermal or mechanical stimulation, or formalin injection., Neuroscience research, 43(4), 2002
- Brain-derived neurotrophic factor-immunoreactive neurons in the rat vagal and glossopharyngeal sensory ganglia; co-expression with other neurochemical substances., Brain research, 1155, 2007
- Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury., Neuroscience, 148(1), 2007
- ★, Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury., Neuroscience, 153(4), 2008
- The number of nociceptors in the trigeminal ganglion but not proprioceptors in the mesencephalic trigeminal tract nucleus is reduced in dystonin deficient dystonia musculorum mice., Brain research, 1226, 2008
- Differential changes in axonal conduction following CNS demyelination in two mouse models., The European journal of neuroscience, 28(9), 2008
- Brn-3a deficiency transiently increases expression of calbindin D-28 k and calretinin in the trigeminal ganglion during embryonic development., Cellular and molecular neurobiology, 29(5), 2009
- Peptide 19 in the rat superior cervical ganglion., Neuroscience, 161(1), 2009
- Persistent hypoglossal artery with hypoplasia of the vertebral and posterior communicating arteries., Anatomical science international, 86(1), 2011
- Differential activation of mitogen-activated protein kinases and glial cells in the trigeminal sensory nuclear complex following lingual nerve injury., Neuroscience research, 69(2), 2011
- Fos protein-like immunoreactive neurons induced by electrical stimulation in the trigeminal sensory nuclear complex of rats with chronically injured peripheral nerve., Experimental brain research, 219(2), 2012
- Effect of adenosine A1 receptor agonist on the enhanced excitability of spinal dorsal horn neurons after peripheral nerve injury., The International journal of neuroscience, 124(3), 2014
- Assessment of intraoral mucosal pain induced by the application of capsaicin., Archives of oral biology, 59(12), 2014
- Possible involvement of convergent nociceptive input to medullary dorsal horn neurons in intraoral hyperalgesia following peripheral nerve injury., Cellular and molecular neurobiology, 35(3), 2015
- Convergent nociceptive input to spinal dorsal horn neurons after peripheral nerve injury., Neurochemical research, 40(3), 2015
- Peripheral nerve injury activates convergent nociceptive input to dorsal horn neurons from neighboring intact nerve., Experimental brain research, 233(4), 2015
- Activated microglia contribute to convergent nociceptive inputs to spinal dorsal horn neurons and the development of neuropathic pain., Neurochemical research, 40(5), 2015
- Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission., Toxins, 7(8), 2015
- Differential Changes in Neuronal Excitability in the Spinal Dorsal Horn After Spinal Nerve Ligation in Rats., Neurochemical research, 41(11), 2016
- Differential induction of c-Fos and phosphorylated ERK by a noxious stimulus after peripheral nerve injury., The International journal of neuroscience, 128(3), 2018
- Basic research and clinical investigations of the neural basis of orofacial pain, JOURNAL OF ORAL BIOSCIENCES, 57(1), 27-36, 2015
- Tunicamycin-Induced Cell Death in the Trigeminal Ganglion is Suppressed by Nerve Growth Factor in the Mouse Embryo, CELLULAR AND MOLECULAR NEUROBIOLOGY, 30(3), 461-467, 2010
- Effect of ionotropic glutamate receptor antagonists on Fos-like immunoreactivity in the dorsal horn following transection of the rat sciatic nerve., Brain research, 934(1), 2002
- Age-dependency of analgesia elicited by intraoral sucrose in acute and persistent pain models., Pain, 97(1-2), 2002
- Differential expression of Fos protein after transection of the rat infraorbital nerve in the trigeminal nucleus caudalis., Brain research, 768(1-2), 1997
- Changes in gene expression and neuronal phenotype in brain stem pain modulatory circuitry after inflammation, JOURNAL OF NEUROPHYSIOLOGY, 87(2), 750-760, 2002
- ★, The roles of NMDA receptor activation and nucleus reticularis gigantocellularis in the time-dependent changes in descending inhibition after inflammation, PAIN, 97(1-2), 171-181, 2002
- Destruction of dorsal root ganglion neurons by isolectin B4-conjugated saporin (IB4-sap), NEUROSCIENCE RESEARCH, 55, S191-S191, 2006
- Activation of caspase cascade underlies the sensory primary neuronal apoptosis induced by neonatal capsaicin and peripheral nerve injury in rats, INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 24(8), 554-554, 2006
- Activation p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury, NEUROSCIENCE RESEARCH, 65, S178-S179, 2009
- A(3) adenosine receptor agonist attenuates neuropathic pain by suppressing activation of microglia and convergence of nociceptive inputs in the spinal dorsal horn, EXPERIMENTAL BRAIN RESEARCH, 236(12), 3203-3213, 201812
- Osteoclastogenesis from bone marrow cells during estrogen-induced medullary bone formation in Japanese quails, JOURNAL OF MOLECULAR HISTOLOGY, 50(4), 389-404, 201908
Invited Lecture, Oral Presentation, Poster Presentation
- Research on neuropathic pain and anatomical education, Terayama R, 2024/11/04, With Invitation, Japanese
- Retinoid-loaded nanoparticles enable targeted bone growth by modulating function of the growth plate, Kenta Uchibe, Ryuji Terayama, The 65th Annual Meeting of Japanese Association for Oral Biology, 2023/09/18, Without Invitation, English, Tokyo
- Differential changes in the induction of c-Fos and phosphorylated ERK in the trigeminal spinal tract nucleus after peripheral nerve injury, Ryuji Terayama, Kenta Uchibe, The 65th Annual Meeting of Japanese Association for Oral Biology, 2023/09/18, Without Invitation, English, Tokyo
- Retinoid-loaded nanoparticles enable targeted bone growth by modulating function of the growth plate, Uchibe K, Terayama R, The 64th Annual Meeting of Japanese Association for Oral Biology, 2022/09/18, Without Invitation, English
- Effect of peripheral nerve injury on the induction of c-Fos and phosphorylated ERK in the trigeminal sensory nuclear complex, Terayama R, Uchibe K, The 64th Annual Meeting of Japanese Association for Oral Biology, 2022/09/18, Without Invitation, English
- Adenosine A3 receptor activation attenuates abnormal pain sensations after peripheral nerve injury, Terayama R, Uchibe K, The 44th Annual Meeting of the Japan Neuroscience Society The 1st CJK International Meeting, 2021/07/28, Without Invitation, English
- Effects of microglial inhibition on neuropathic pain, Terayama R, Uchibe K, The 63rd Annual Meeting of Japanese Association for Oral Biology, 2021/10/10, Without Invitation, English, Japanese Association for Oral Biology, Yokosuka
- Roles of retinoic acid signaling in chondrocytes, Uchibe K, Terayama R, The 62nd Annual Meeting of Japanese Association for Oral Biology, 2020/09/11, Without Invitation, English, Japanese Association for Oral Biology, Kagoshima (WEB)
- Possible mechanisms for the effects of A3 adenosine receptor agonist on neuropathic pain, Ryuji Terayama, Kenta Uchibe, The 62nd Annual Meeting of Japanese Association for Oral Biology, 2020/09/11, Without Invitation, English, Japanese Association for Oral Biology, Kagoshima (WEB)
- Abnormal pain sensation and changes in the spinal dorsal horn after peripheral nerve injury, Ryuji Terayama, The 24th Annual Meeting of Japanese Association for Orofacial Pain, 2019/09/29, With Invitation, Japanese, Japanese Association for Orofacial Pain, Kawasaki
- Effect of A3 adenosine receptor agonist on neuropathic pain, Ryuji Terayama, The 74th Annual Meeting of the Japanese Association of Anatomists Chugoku-Shikoku Chapter, 2019/10/26, Without Invitation, Japanese, Japanese Association of Anatomists Chugoku-Shikoku Chapter, Izumo
- A3 adenosine receptor agonist attenuates neuropathic pain by suppressing activation of microglia and convergence of nociceptive inputs in the spinal dorsal horn, Ryuji Terayama, The 61st Annual Meeting of Japanese Association for Oral Biology, 2019/10/12, Without Invitation, English, apanese Association for Oral Biology, Tokyo
- Differential Changes in Neuronal Excitability in the Spinal Dorsal Horn After Spinal Nerve Ligation in Rats., Ryuji Terayama, The 43rd Seminer of Okayama Brain Research, 2017/01/29, Without Invitation, Japanese, Seminer of Okayama Brain Research, Okayama
- Changes in the spinal dorsal horn involved in neuropathic pain., Ryuji Terayama, The 44th Okayama Brain Research Seminar, 2017/10/14, With Invitation, Japanese, Okayama Brain Research Seminar, Okayama
- Differential induction of c-Fos and phosphorylated ERK by a noxious stimulus after peripheral nerve injury., Tabata M, Terayama R, Maruhama K, Iida S, Sugimoto T., 2017/10/28, Without Invitation, Japanese, The Japanese Association of Anatomist, Hiroshima
- Differential induction of c-Fos and phosphorylated ERK after peripheral nerve injury, Ryuji Terayama, Kotaro Maruhama, The 60th Annual Meeting of Japanese Association for Oral Biology, 2018/09/06, Without Invitation, English, Japanese Association for Oral Biology, Fukuoka
- Basic Research for Neropathic Pain, Ryuji Terayama, With Invitation, Japanese, Hiroshima
- Memory of Pain -Chrinic Pain andNeurnal Plasticity-, Ryuji Terayama, 2018/10/24, With Invitation, Japanese, Hiroshima
External Funds
Acceptance Results of Competitive Funds
- KAKENHI(Grant-in-Aid for Scientific Research (C)), 2019, 2021
Social Activities
History as Peer Reviews of Academic Papers
- 2021, The Anatomical Record, Others, Reviewer, 1
- 2020, Journal of Pain Research, Others, Reviewer, 1
- 2019, International Journal of Neuroscience, Others, Reviewer, 1
- 2018, Journal of Receptors and Signal Transduction, Others, Reviewer, 1
- 2018, Cell Tissue Organs, Others, Reviewer, 2