HIROKI IKENAGA

Last Updated :2025/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Assistant Professor
E-mail
hirokiikenagayahoo.co.jp
Self-introduction
Speciality: Catheter intervention, intracoronary imaging, micovascular dysfunction SHD intervention (TAVI, M-TEER (MitraClip, PASCAL), PFO occluder)

Basic Information

Major Professional Backgrounds

  • 2012/04/01, 2013/03/31, Hiroshima University, Hospital, Clinical Fellow
  • 2017/10/23, 2018/08/21, Cedars-Sinai Medical Center, Research Scholar
  • 2018/09/01, 2021/09/30, Hiroshima University, Hospital, Assistant Professor
  • 2017/04/01, 2018/08/31, Hiroshima University, Hospital, Clinical Fellow
  • 2007/04/01, 2012/03/31, Hiroshima City Hiroshima Citizens Hospital, Doctor

Educational Backgrounds

  • Hiroshima university, Faculty of Medicine, Japan, 1999/04, 2005/03
  • Hiroshima University, Graduate School of Biomedical & Health Sciences, Japan, 2013/04, 2017/03

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Cardiovascular medicine

Research Keywords

  • Catheter intervention, intracoronary imaging, microvascular dysfunction, SHD intervention (TAVI, M-TEER(MitraClip, PASCAL), PFO occluder)

Affiliated Academic Societies

  • Japanese Society of Internal Medicine (Fellow of the Japanese Society of Internal Medicine) Japanese Circulation Society (Fellow of the Japanese Circulation Society) Japanese Association of Cardiovascular Intervention and Therapeutics (Fellow of the Japanese Association of Cardiovascular Intervention and Therapeutics) Japanese Association of Cardioangioscopy (Board Certified Member of the Japanese Association of Cardioangioscopy) Japan Transcatheter Valve Therapies

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Intensive, Introduction to clinical clerkship
  2. 2025, Undergraduate Education, Intensive, Practice of Medicine I

Research Activities

Academic Papers

  1. Importance of the Assessment of Physical Frailty in Elderly Japanese Patients With Acute Myocardial Infarction, Circ J, 24(87), 498-499, 202303
  2. Contemporary Survival Trends After Transcatheter Aortic Valve Implantation., Circ J, 13, 202312
  3. Rationale and design of the INVICTUS Registry: (Multicenter Registry of Invasive and Non-Invasive imaging modalities to compare Coronary Computed Tomography Angiography, Intravascular Ultrasound and Optical Coherence Tomography for the determination of Severity, Volume and Type of coronary atherosclerosiS), JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, 17(6), 401-406, 2023
    Link to Paper Search Results by DOI
  4. Relationship between the Selvester QRS Score and Coronary Microvascular Dysfunction Assessed by the Index of Microcirculatory Resistance, INTERNAL MEDICINE, 62(24), 3591-3599, 2023
    Link to Paper Search Results by DOI
  5. Intravascular Ultrasound Features of Coronary Artery Disease with Triglyceride Deposit Atherosclerosis, AMERICAN JOURNAL OF CARDIOLOGY, 206, 105-107, 20231101
    Link to Paper Search Results by DOI
  6. JCS/CVIT/JCC 2023 guideline focused update on diagnosis and treatment of vasospastic angina (coronary spastic angina) and coronary microvascular dysfunction, JOURNAL OF CARDIOLOGY, 82(4), 293-341, 202310
    Link to Paper Search Results by DOI
  7. Determination of lipid-rich plaques by artificial intelligence-enabled quantitative computed tomography using near-infrared spectroscopy as reference, ATHEROSCLEROSIS, 386, 202312
    Link to Paper Search Results by DOI
  8. The reliability and utility of on-site CT-derived fractional flow reserve (FFR) based on fluid structure interactions: comparison with FFRCT based on computational fluid dynamics, invasive FFR, and resting full-cycle ratio, HEART AND VESSELS, 38(9), 1095-1107, 202309
    Link to Paper Search Results by DOI
  9. Left-atrial volume reduction reflects improvement of cardiac sympathetic nervous function in patients with severe aortic stenosis after transcatheter aortic valve replacement, HEART AND VESSELS, 38(8), 1083-1091, 202308
    Link to Paper Search Results by DOI
  10. JCS/CVIT/JCC 2023 Guideline Focused Update on Diagnosis and Treatment of Vasospastic Angina (Coronary Spastic Angina) and Coronary Microvascular Dysfunction, CIRCULATION JOURNAL, 87(6), 879-936, 202306
    Link to Paper Search Results by DOI
  11. Relationship Between Attenuated Plaque Identified by Intravascular Ultrasound and Thrombus Formation After Excimer Laser Coronary Angioplasty, CARDIOVASCULAR REVASCULARIZATION MEDICINE, 49, 15-21, 202304
    Link to Paper Search Results by DOI
  12. Factors Influencing Cardiac Sympathetic Nervous Function in Patients With Severe Aortic Stenosis: Assessment by I-123-Metaiodobenzylguanidine Myocardial Scintigraphy, HEART LUNG AND CIRCULATION, 31(5), 671-677, 202205
    Link to Paper Search Results by DOI
  13. Wave Terminal Force V1 Is Associated with Left Ventricular Diastolic Function in Patients with No Significant Perfusion Abnormality Assessment by Myocardial Perfusion Single-Photon Emission Computed Tomography, INTERNATIONAL HEART JOURNAL, 63(2), 299-305, 202203
    Link to Paper Search Results by DOI
  14. ★, Predictive Value of Plaque Morphology Assessed by Frequency-Domain Optical Coherence Tomography for Impaired Microvascular Perfusion after Elective Stent Implantation -the Intracoronary Electrocardiogram Study-, Eur Heart J Cardiovasc Imaging., 19(3), 310-318, 20180301
  15. Relation Between Pulmonary Venous Flow and Left Atrial Pressure During Percutaneous Mitral Valve Repair With the MitraClip., Am J Cardiol, 272, 185-188, 201812
  16. Association of QRS duration with left ventricular volume and ejection fraction after anterior myocardial infarction assessed by gated single photon emission computed tomography, ACTA CARDIOLOGICA, 73(4), 371-376, 2018
    Link to Paper Search Results by DOI
  17. Radiofrequency catheter ablation is effective for atrial fibrillation patients with hypertrophic cardiomyopathy by decreasing left atrial pressure., J Arrhythm, 33(4), 256-261, 201708
  18. Impact of Malondialdehyde-Modified Low-Density Lipoprotein on Tissue Characteristics in Patients With Stable Coronary Artery Disease- Integrated Backscatter-Intravascular Ultrasound Study., Circ J, 80(10), 2173-2182, 201609
  19. Slow-flow phenomenon after Paclitaxel-coated balloon angioplasty: findings from optical coherence tomography and coronary angioscopy., JACC Cardiovasc Interv, 8(4), e59-e62, 201504
  20. Optical Coherence Tomography Findings After Scoring Balloon Dilatation., Rev Esp Cardiol, 68(11), 1022-1022, 201511
  21. Predictive value of neutrophil to lymphocyte ratio for the presence of coronary artery ectasia in patients with aortic aneurysms., Int J Cardiol Heart Vessel., 15(4), 30-34, 201408
  22. Effects of the topographical extent of coronary artery ectasia on coronary blood flow in patients with aortic aneurysms., Heart Vessels., 30(6), 712-718, 201511
  23. Longitudinal extent of lipid pool assessed by optical coherence tomography predicts microvascular no-reflow after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction., J Cardiol., 62(2), 71-76, 201308
  24. Mechanisms of very late stent thrombosis after drug-eluting stent implantation: findings from coronary angioscopy and optical coherence tomography., JACC Cardiovasc Imaging., 4(11), 1217-1219, 201111
  25. Usefulness of Lipoprotein (a) for predicting progression of non-culprit coronary lesions after acute myocardial infarction., Circ J., 75(12), 2847-2852, 2011
  26. Very late stent thrombosis after sirolimus-eluting stent implantation observed using optical coherence tomography and coronary angioscopy., J Invasive Cardiol., 22(11), 557-558, 201010
  27. Frontal QRS-T angle and World Health Organization classification for body mass index, INTERNATIONAL JOURNAL OF CARDIOLOGY, 272, 185-188, 20181201
    Link to Paper Search Results by DOI
  28. Myocardial perfusion defect assessed by single-photon emission computed tomography and frontal QRS-T angle in patients with prior anterior myocardial infarction, HEART AND VESSELS, 34(6), 971-975, 201906
    Link to Paper Search Results by DOI
  29. Coronary Artery Calcium Is Associated with Left Ventricular Diastolic Function Independent of Myocardial Ischemia Assessment by Myocardial Perfusion Single-Photon Emission Computed Tomography, INTERNATIONAL HEART JOURNAL, 60(3), 554-559, 201905
    Link to Paper Search Results by DOI
  30. Effects of deep inspiration on QRS axis, T-wave axis and frontal QRS-T angle in the routine electrocardiogram, HEART AND VESSELS, 34(9), 1519-1523, 201909
    Link to Paper Search Results by DOI
  31. Elevated Plasma Renin Activity Caused by Accelerated-malignant Hypertension in a Patient with Aldosterone-producing Adenoma Complicated with Renal Insufficiency, INTERNAL MEDICINE, 58(21), 3107-3111, 2019
    Link to Paper Search Results by DOI
  32. Percutaneous Coronary Intervention for Interposed Coronary Graft Stenosis after Modified Bentall Procedure in a Teenaged Boy with Takayasu Arteritis, TEXAS HEART INSTITUTE JOURNAL, 46(3), 207-210, 201906
    Link to Paper Search Results by DOI
  33. Comprehensive Evaluation of Tricuspid Regurgitation Location and Severity Using Vena Contracta Analysis: A Color Doppler Three-Dimensional Transesophageal Echocardiographic Study, JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 32(12), 1526-+, 201912
    Link to Paper Search Results by DOI
  34. Effects of Myocardial Perfusion Defect on the Frontal QRS-T Angle in Anterior Versus Inferior Myocardial Infarction, INTERNAL MEDICINE, 59(1), 23-28, 2020
    Link to Paper Search Results by DOI
  35. Associations of left ventricular shape with left ventricular volumes and functions assessed by ECG-gated SPECT in patients without significant perfusion abnormality, HEART AND VESSELS, 35(1), 86-91, 202001
    Link to Paper Search Results by DOI
  36. Diagnostic value of peak filling rate derived from ECG-gated myocardial perfusion SPECT for detecting myocardial ischaemia in patients with non-obstructive coronary artery disease, ACTA CARDIOLOGICA, 75(1), 37-41, 20200102
    Link to Paper Search Results by DOI
  37. Frontal QRS-T angle and left ventricular diastolic function assessed by ECG-gated SPECT in the absence of significant perfusion abnormality, HEART AND VESSELS, 35(8), 1095-1101, 202008
    Link to Paper Search Results by DOI
  38. Effects of aging on coronary flow reserve in patients with no evidence of myocardial perfusion abnormality, HEART AND VESSELS, 35(12), 1633-1639, 202012
    Link to Paper Search Results by DOI
  39. Effects of upright T-wave in lead aVR on left ventricular volume and function derived from ECG-gated SPECT in patients with advanced chronic kidney disease, ANNALS OF NUCLEAR MEDICINE, 35(1), 1-7, 202101
    Link to Paper Search Results by DOI
  40. Effects of Newly Developed Right Versus Left Bundle Branch Block on the QRS Axis, T-wave Axis and Frontal QRS-T Angle in Patients with a Narrow QRS, INTERNAL MEDICINE, 60(1), 25-30, 2021
    Link to Paper Search Results by DOI
  41. Impact of Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement on Changes in Cardiac Sympathetic Nervous Function Assessment by 123I-Metaiodobenzylguanidine Myocardial Scintigraphy, INTERNATIONAL HEART JOURNAL, 61(6), 1188-1195, 202011
    Link to Paper Search Results by DOI
  42. Associations of frontal QRS-T angle with left ventricular volume and function derived from ECG-gated SPECT in patients with advanced chronic kidney disease, ANNALS OF NUCLEAR MEDICINE, 35(6), 662-668, 202106
    Link to Paper Search Results by DOI
  43. Aortic valve calcium is associated with left ventricular diastolic function in patients without evidence of ischaemic heart disease: assessment by gated single-photon emission computed tomography, ACTA CARDIOLOGICA, 76(4), 359-364, 20210704
    Link to Paper Search Results by DOI
  44. Effects of aging on coronary flow reserve in patients with no evidence of myocardial perfusion abnormality, Heart Vessels ., 35(12), 1633-1639, 20200610
  45. Effects of Myocardial Perfusion Defect on the Frontal QRS-T Angle in Anterior Versus Inferior Myocardial Infarction, Intern Med, 59(1), 23-28, 20200101
  46. Impact of Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement on Changes in Cardiac Sympathetic Nervous Function, Int Heart J ., 61(6), 1188-1195, 20201128
  47. The Impact of Valvuloarterial Impedance on Left Ventricular Geometrical Change after Transcatheter Aortic Valve Replacement: A Comparison between Valvuloarterial Impedance and Mean Pressure Gradient., 9(10), 3143-3143, 20200729
  48. Diagnostic value of peak filling rate derived from ECG-gated myocardial perfusion SPECT for detecting myocardial ischaemia in patients with non-obstructive coronary artery disease, Acta Cardiol ., 75(1), 37-41, 20200201
  49. The association between epicardial adipose tissue thickness around the right ventricular free wall evaluated by transthoracic echocardiography and left atrial appendage function, Int J Cardiovasc Imaging ., 36(4), 585-593, 20200401
  50. Diagnostic value of peak filling rate derived from ECG-gated myocardial perfusion SPECT for detecting myocardial ischaemia in patients with non-obstructive coronary artery disease, 75(1), 37-41, 20200201
  51. Peri-stent contrast staining after ultrathin, biodegradable polymer sirolimus-eluting stent implantation: findings from optical coherence tomography and coronary angioscopy, Cardiovasc Interv Ther ., 20210123
  52. Impact of Percutaneous Edge-to-Edge Repair in Patients With Atrial Functional Mitral Regurgitation, Circ J ., 85(7), 1001-1010, 20210625
  53. Prevalence, distribution, and determinants of pulmonary venous systolic flow reversal in severe mitral regurgitation, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 22(9), 964-973, 202109
    Link to Paper Search Results by DOI
  54. The Monocyte to High-Density Lipoprotein Cholesterol Ratio Is Associated with Left Ventricular Diastolic Function in Patients with No Significant Perfusion Abnormality Assessment by Myocardial Perfusion Single-Photon Emission Computed Tomography, INTERNATIONAL HEART JOURNAL, 62(4), 866-871, 202107
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. How to assess TR, Ikenaga Hiroki, Echo Asia Hong Kong Conference, 2021/05/28, With Invitation, English

Awards

  1. 2016/06/10, Young Investigator's Award, 日本循環器学会中国四国合同地方会, 冠動脈内心電図、光干渉断層法を用いた経皮的カテーテル治療の術中微小循環障害による心筋傷害の予測
  2. 2014, The International Travel Grants of Hiroshima University Funds, Hiroshima University Funds