Haruhisa Watanabe

Last Updated :2026/04/16

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Assistant Professor (Special Appointment)

Basic Information

Major Professional Backgrounds

  • 2024/04, 2026/03
  • 2020/04, 2026/03

Educational Backgrounds

  • Hokkaido University, Graduate School of Dental Medicine, 2020/04, 2024/03
  • Hiroshima University, Faculty of Dentistry, 2013/04, 2019/03

Academic Degrees

  • Doctor of Philosophy, Hokkaido University

Affiliated Academic Societies

  • The International Association for the Study of the Pain, 2023, 9999
  • Japanese Society for Bone Morphometry, 2023, 9999
  • The Japanese Pharmacological Society, 2023, 9999
  • The Japanese Society for Bone and Mineral Research, 2022, 9999
  • The Japanese Society of Temporomandibular Joint, 2021, 9999
  • Japanese Society of Orofacial Pain, 2020, 9999
  • Japanese Stomatological Society, 2020, 9999
  • Japanese Society of Oral and Maxillofacial Surgeons, 2019, 9999

Research Activities

Academic Papers

  1. Effectiveness of Zinc Replacement Therapy With Zinc Acetate Dihydrate in Patients With Taste Disorder Associated With Zinc Deficiency: An Observational Study, Oral Science International, 23(2), 20260217
  2. A Case of Mandibular Osteomyelitis Occurring in a Patient With Parry-Romberg Syndrome., Cureus, 17(12), e99021, 202512
  3. Bone Metabolic Changes and Osteoporosis During Pregnancy and Lactation: A View from Dental Medicine, International Journal of Molecular Sciences, 26(21), 20251028
  4. Establishment of artificial intelligence-driven fluorescence morphometry reveals involvement of osteocyte perilacunar remodeling specifically in mandibular bone of ovariectomized rats., Microscopy (Oxford, England), 20251017
  5. A Long-Term (41 Years) Radiographic Follow-Up Study of the Onset and Development of a Jawbone Lesion in a Patient With Gnathodiaphyseal Dysplasia., Cureus, 17(7), e88763, 202507
  6. SARS-CoV-2 infection promotes lung thrombosis by inducing integrinβ3 expression in vascular endothelial cells., Scientific reports, 15(1), 20447-20447, 20250701
  7. Genome-wide analyses of susceptibility genes responsible for mandibular prognathism in the Japanese population, Journal of Oral Biosciences, 67(2), 100670-100670, 202506
  8. ★, Chemokine receptor 5 signaling in oral diseases and degenerative temporomandibular joint disease, Journal of Oral Biosciences, 67(2), 100666-100666, 202506
  9. Cholesterol metabolism and neuroinflammatory changes in a non-human primate spinal nerve ligation model., Scientific reports, 15(1), 11462-11462, 20250403
  10. Exploration and identification of susceptible genes for mandibular prognathism by genome-wide analysis, 北海道歯学雑誌, 45, 12-15, 202409
  11. Pharmacological effeats of PTH1R agonists on the mandibular bone and their application to orthodontic treatment, 北海道歯学雑誌, 45, 16-21, 202409
  12. Retrospective study of patients with burning mouth syndrome accompanied by hypozincemia, 北海道歯学雑誌, 45, 31-39, 202409
  13. Enhanced phagocytosis associated with multinucleated microglia via Pyk2 inhibition in an acute β-amyloid infusion model, Journal of Neuroinflammation, 21(1), 196-196, 20240806
  14. Examination of the duration of vitamin B12 administration for hypoesthesia caused by inferior alveolar nerve injury after horizontally impacted mandibular third molar: A retrospective study, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 37th, 202408
  15. Dynamic morphometric changes in the mandibular osteocytic lacunae of ovariectomized rats in response to teriparatide, as revealed by three-dimensional fluorescence analyses: Possible involvement of osteocytic perilacunar remodeling., Journal of oral biosciences, 66(1), 49-60, 202403
  16. Viral uptake and pathophysiology of the lung endothelial cells in age-associated severe SARS-CoV-2 infection models., Aging cell, 23(2), e14050, 202402
  17. My Three-Sword style as a parent, a clinician and a researcher; Potential applications of an osteoporosis drug to orthodontics, 北海道矯正歯科学会雑誌, 52(1), 61-68, 2024
  18. Evaluation of cortical bone remodeling in canines treated with daily and weekly administrations of teriparatide by establishing AI-driven morphometric analyses and GIS-based spatial mapping., Bone reports, 19, 101720-101720, 202312
  19. Centrosome clustering control in osteoclasts through CCR5-mediated signaling., Scientific reports, 13(1), 20813-20813, 20231127
  20. Potential relationship between the dosage of prednisolone and delayed healing at tooth extraction: A retrospective study., Journal of dental sciences, 18(4), 1765-1770, 202310
  21. An unexpected relationship between alcohol tolerance and bone mass, 北海道歯学雑誌, 44, 10-11, 202309
  22. Pathophysiological roles of chemokine CCL5 and its potential as a biomarker in degenerative joint disease of temporomandibular joint, 北海道歯学雑誌, 44, 12-15, 202309
  23. ★, Skeletal-Vascular Interactions in Bone Development, Homeostasis, and Pathological Destruction, International Journal of Molecular Sciences, 24(13), 20230630
  24. ★, Association between an Increased Serum CCL5 Level and Pathophysiology of Degenerative Joint Disease in the Temporomandibular Joint in Females, International Journal of Molecular Sciences, 24(3), 202302
  25. A case of combined glossopharyngeal and trigeminal neuralgia triggered by taste stimulation, 日本口腔外科学会雑誌, 68(9), 392-399, 202209
  26. Ethyl loflazepate as a treatment for patients with idiopathic and psychogenic taste disorder., BioPsychoSocial medicine, 16(1), 16-16, 20220808
  27. The effect of ethyl loflasebate for patients of idiopathic and psychogenesis taste disorder, 日本歯科心身医学会雑誌, 36(1-2), 71-72, 202112
  28. Drug-induced Taste Disorder in Dentistry, 日本口腔診断学会雑誌, 34(2), 101-105, 202106
  29. 良性線維性組織球腫が疑われる下顎骨の紡錘形細胞病変の稀な1例(A rare case of spindle cell lesion in the mandible possible with benign fibrous histiocytoma), Oral Science in Japan, 2021, 41-42, 2021
  30. Immediate oral surgical management of external dental fistula: Technical note of immediate tooth autotransplantation, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 33(6), 623-625, 2021
  31. Teriparatide reduces spinal neuroinflammatory phenotypes in ovariectomized rats revealed by an artificial intelligence-driven glial cell morphometry of bright-field tissue sections., Microscopy (Oxford, England), 2026

Publications such as books

  1. 2021, 良性線維性組織球腫が疑われる下顎骨の紡錘形細胞病変の稀な1例(A rare case of spindle cell lesion in the mandible possible with benign fibrous histiocytoma), 良性線維性組織球腫が疑われる下顎骨の紡錘形細胞病変の稀な1例(A rare case of spindle cell lesion in the mandible possible with benign fibrous histiocytoma), (NPO)日本口腔科学会, eng, Watanabe Haruhisa; Yoshikawa Kazuhito; Sato Jun; Matsuda Aya; Kitagawa Yoshimasa
  2. 2020, 開口障害から早期に破傷風が診断され救命に成功した患者の一例(Early diagnosis from trismus leading to successful life-saving in a patient with tetanus), 開口障害から早期に破傷風が診断され救命に成功した患者の一例(Early diagnosis from trismus leading to successful life-saving in a patient with tetanus), (NPO)日本口腔科学会, eng, Watanabe Haruhisa; Ishikawa Makoto; Kitagawa Yoshimasa

Invited Lecture, Oral Presentation, Poster Presentation

  1. 孝口里侑、渡辺陽久、高倉綾、鈴木啓明、飯村忠浩, 2025/07/25
  2. Differentiation potential of human bone marrow-derived mesenchymal stem cells cultured with laminin-511 E8 fragment, H Watanabe; M Nishiura; A Hirota; T Yamamoto; T Iimura, Society for neuroscience 2024
  3. A rare case of spindle cell lesion in the mandible possibly with benign fibrous histiocytoma: with a literature review, Watanabe H.; Yoshikawa K.; Matsuda A.; Sato J.; Kitagawa Y, 2022
  4. 渡辺陽久, 2021
  5. Surface-immobilization of neurotrophin-4 mimetic peptide for the selective binding of a TrkB-expressing cell population from iPS cells,, Haruhisa Watanabe; Aimi N. Abdullah; Yuuka Yamauchi; Isao Hirata; Koichi Kato, THE 6TH JAPAN-CHINA SYMPOSIUM ON NANOMEDICINE, 2018/05/25

Awards

  1. 2019/03, Dentsply Sirona Merit Award

External Funds

Acceptance Results of Competitive Funds

  1. 2025/04/01, 2028/03/31
    Permalink
  2. Grants-in-Aid for Scientific Research, Uncovering the pathophysiological association between mechanical load and CCR5 signaling in condyler resorption of temporomandibular joint, 2025/04, 2028/03
    Permalink
  3. 2025/06/27, 2027/03/31
    Permalink
  4. 2024/09, 2027/03
    Permalink