SHIGENORI MIURA

Last Updated :2024/05/07

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Associate Professor
E-mail
miurashiroshima-u.ac.jp
Self-introduction
I'd like to elucidate the molecular mechanisms underlying the development of the musculoskeletal system, including tendons and ligaments, focusing on the mechanical stresses and angiogenesis, using genetically modified animals and in vitro tissue models.

Basic Information

Major Professional Backgrounds

  • 2023/07/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Associate Professor
  • 2022/04/01, 2023/06/30, The University of Tokyo, Graduate School of Information Science and Technology, Project Associate Professor
  • 2018/09/01, 2022/03/31, The University of Tokyo, Institute of Industrial Scoence, Project Lecturer
  • 2016/10/01, 2018/08/31, Kyoto University, Institute for Frontier Life and Medical Sciences, Assistant Professor
  • 2014/04/01, 2016/09/30, Kyoto University, Institute for Frontier Medical Sciences, Assistant Professor
  • 2012/04/01, 2014/03/31, The University of Tokyo, Institute of Industrial Science, Project Researcher
  • 2010/04/01, 2012/03/31, Kyoto University, Institute for Frontier Medical Sciences, Program-Specific Researcher
  • 2006/04/01, 2010/03/31, Kyoto University, Institute for Frontier Medical Sciences, Assistant Research Staff, Research Fellow

Educational Backgrounds

  • Kyoto University, Graduate School of Medicine, Japan, 2002/04/01, 2006/03/23
  • Kyoto University, Graduate School of Engineering, Japan, 1998/04/01, 2000/03/23
  • Kyoto University, Faculty of Engineering, Japan, 1994/04/01, 1998/03/24

Academic Degrees

  • Kyoto University
  • Kyoto University

Research Fields

  • Biology;Biological Science;Cell biology
  • Complex systems;Biomolecular science;Biomolecular chemistry
  • Biology;Biological Science;Developmental biology
  • Complex systems;Biomedical engineering;Biomedical engineering / Biomaterial science and engineering

Research Keywords

  • tendon/ligament
  • mechanobiology
  • bone/cartilage
  • blood vessel

Affiliated Academic Societies

  • The Molecular Biology Society of Japan
  • The Japanese Society for Regenerative Medicine
  • The Japanese Society for Genome Editing
  • Japan Muscle Society
  • Society for Chemistry and Micro-Nano Systems

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 2Term, Foundation physics for life science
  2. 2024, Undergraduate Education, 1Term, Oral Biochemistry I
  3. 2024, Undergraduate Education, 2Term, Oral Biochemistry II
  4. 2024, Undergraduate Education, 2Term, Oral Biochemistry II
  5. 2024, Undergraduate Education, 2Term, Oral Biochemistry II
  6. 2024, Undergraduate Education, 3Term, Practice of Oral Biochemistry
  7. 2024, Undergraduate Education, 3Term, Molecular Biology in Medicine
  8. 2024, Undergraduate Education, 2Term, Topics in Dental Research II
  9. 2024, Undergraduate Education, Second Semester, Dental Research Practices II
  10. 2024, Undergraduate Education, 1Term, Basic Biochemistry
  11. 2024, Undergraduate Education, 1Term, Basic Biochemistry

Research Activities

Academic Papers

  1. Small-Artery-Mimicking Multi-Layered 3D Co-Culture in Self-Folding Porous Graphene-Based Film., Nanoscale Horizon, 8(11), 1529-1536, 20231023
    Link to Paper Search Results by DOI
  2. Spatiotemporal single-cell tracking analysis in 3D tissues to reveal heterogeneous cellular response to mechanical stimuli., Science Advances, 9(41), eadf9917-eadf9917, 20231013
    Link to Paper Search Results by DOI
  3. Bioprinting soft collagen tissues embedded with perfusable branching channels., Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022, 334-335, 2022
  4. Rod-shaped osteoblastic tissues fabricated using tissue modeling method with micro-anchor devices., Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022, 344-345, 2022
  5. Protein expression micro-scale mapping analysis of endothelial tissue in in vitro branched vascular model under mechanical stimuli., Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) 2022, 283-286, 2022
  6. Functional analysis of human brain endothelium using a microfluidic device integrating a cell culture insert., APL bioengineering, 6(1), 016103-016103, 2022
  7. Pulsatile flow analysis at branched point in ECM-based endothelial vascular model under mechanical stretch., Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021, 305-306, 2021
  8. Shape retaining and sacrificial molding fabrication method for ECM-based in vitro vascular model., Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) 2021, 230-233, 2021
  9. Real time three-dimensional single cell-resolution monitoring system for observation of dynamic cell behavior under mechanical stimuli., Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) 2021, 454-457, 2021
  10. Membrane-integrated Glass Chip for Two-Directional Observation of Epithelial Cells., Sensors and Actuators: B. Chemical, 326, 128861-128861, 2021
  11. Microfluidic system for applying shear flow to endothelial cells on culture insert with collagen vitrigel membrane., Sensors and Actuators: B. Chemical, 348, 130675-130675, 2021
  12. Formation of contractile skeletal muscle tissue with tendon tissue at both ends., Proceedings of the 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020, 839-840, 2020
  13. ECM-based microchannel for culturing in vitro vascular tissues with simultaneous perfusion and stretch., Lab on a chip, 20(11), 2020
  14. Microfluidic Device for the Analysis of Angiogenic Sprouting under Bidirectional Biochemical Gradients., Micromachines, 11(12), 2020
  15. Stretching Motion-driven ECM-based Pulsatile Flow Generator for Mimicking Venous Blood Flow in vivo., Proceedings of the 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, 314-315, 2019
  16. ECM-based Stretchable Microfluidic System for in vitro 3D Tissue Culture., 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII), 752-755, 2019
  17. Shape Deformation Analysis of Single Cell in 3D Tissue Under Mechanical Stimuli., 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII), 413-416, 2019
  18. Centrifuge-based step emulsification device for simple and fast generation of monodisperse picoliter droplets., Sensors and Actuators: B. Chemical, 301, 127164-127164, 2019
  19. THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis., Journal of bone and mineral metabolism, 36(4), 410-419, 2018
  20. Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes., Scientific reports, 8(1), 3155-3155, 2018
  21. Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation., PLoS genetics, 12(1), 2016
  22. A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis., American journal of human genetics, 97(2), 2015
  23. Light generation of intracellular Ca(2+) signals by a genetically encoded protein BACCS., Nature communications, 6, 2015
  24. ★, Fluid shear triggers microvilli formation via mechanosensitive activation of TRPV6., Nature communications, 6, 2015
  25. ★, The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development., PloS one, 9(4), 2014
  26. Glass-capillary-accessible Dynamic Microarray for Microinjection of Zebrafish Embryos., Proceedings of the 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 452-454, 2013
  27. 3D Fiber-shaped Culture System Promotes Differentiation of Multipotent DFAT Cells into Smooth Muscle-like Cells., Proceedings of the 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 410-412, 2013
  28. Multi-layered Placental Barrier Structure Integrated with Microflidic Channels., Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) 2013, 257-258, 2013
  29. Self-assembly of Cell Springs Using Smooth Muscle-like Cells Differentiated from Multipotent Cells., Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) 2013, 71-73, 2013
  30. Metre-long cell-laden microfibres exhibit tissue morphologies and functions., Nature materials, 12(6), 2013
  31. Biofabrication of Living Vessel Structures Integrated with Fluid Perfusion., Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2012), 1723-1725, 2012
  32. ★, Synthetic disulfide-bridged cyclic peptides mimic the anti-angiogenic actions of chondromodulin-I., Cancer science, 103(7), 2012
  33. Localization of chondromodulin-I at the feto-maternal interface and its inhibitory actions on trophoblast invasion in vitro., BMC cell biology, 12, 2011
  34. A functional role of the glycosylated N-terminal domain of chondromodulin-I., Journal of bone and mineral metabolism, 29(1), 2011
  35. ★, Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor., Experimental cell research, 316(5), 2010
  36. Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells., Journal of bone and mineral metabolism, 28(6), 2010
  37. Benzene metabolite hydroquinone up-regulates chondromodulin-I and inhibits tube formation in human bone marrow endothelial cells., Molecular pharmacology, 76(3), 2009
  38. Chondromodulin-I and tenomodulin are differentially expressed in the avascular mesenchyme during mouse and chick development., Cell and tissue research, 332(1), 2008
  39. Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis., Circulation, 118(17), 2008
  40. Nondestructive isolation of single cultured animal cells by femtosecond laser-induced shockwave., Applied Physics A, 79, 795-798, 2004
  41. Screening of Genes Involved in Isooctane Tolerance in Saccharomyces cerevisiae by Using mRNA Differential Display., Applied and Environmental Microbiology, 66(11), 4883-4889, 2000