NORIKO SAITO

Last Updated :2025/06/16

Affiliations, Positions
Hiroshima University Hospital, Assistant Professor
E-mail
r14saitohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Kyushu Dental College

In Charge of Primary Major Programs

  • Dentistry

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Conservative dentistry

Research Keywords

  • Operative Dentistry, Restorative Dentistry, Endodontics, semaphorin 7A, recessed tooth (endodontic), GDNF

Affiliated Academic Societies

  • Japanese Association for Oral Biology, 2011/06, 2024/12
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  • Japanese Dental Education Association, 2015/05, 2024/12
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  • Japan Dental Society of Oriental Medicine, 2019/06
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  • Japan Endodontic Association, 2011/08
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  • The Japanese Society of Conservative Dentistry, 2009/05
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Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, First Semester, Early Clinical Exposure I
  2. 2025, Undergraduate Education, 3Term, Operative Dentistry I
  3. 2025, Undergraduate Education, 4Term, Operative Dentistry II
  4. 2025, Undergraduate Education, Second Semester, Early Clinical Exposure II
  5. 2025, Undergraduate Education, 1Term, Basic Practice of Endodontics and Operative Dentistry I
  6. 2025, Undergraduate Education, 2Term, Basic Practice of Endodontics and Operative Dentistry II
  7. 2025, Undergraduate Education, Second Semester, Early Clinical Exposure III
  8. 2025, Undergraduate Education, 2Term, Advanced Course in Functional and Regenerative Oral Medicine
  9. 2025, Undergraduate Education, 2Term, General Seminar on Clinical Dentistry
  10. 2025, Undergraduate Education, 2Term, Basic and Clinical Integrated Theory
  11. 2025, Undergraduate Education, First Semester, Dental Research Practices III
  12. 2025, Undergraduate Education, Year, Clinical Practice (Preventive Dentistry)
  13. 2025, Undergraduate Education, Year, Clinical Practice (Endodontics and Operative Dentistry)
  14. 2025, Undergraduate Education, 3Term, Endodontology
  15. 2025, Undergraduate Education, 3Term, Endodontorogy

Research Activities

Academic Papers

  1. Creating an Environment for Root Canal Treatment on Remaining Teeth, Journal of the Japanese Endodontic Association, 41, 155-164, 202009
  2. Two-year clinical comparison of flowable-type nano-hybrid composite and paste-type composite in posterior restoration., Journal of Investigative and Clinical Dentistry, 8(3), 201608
    Link to Paper Search Results by DOI
  3. Increasing the Apical Sizes of Root Enlarged for Root Canal Obturation Influences the Outcome of Single-Root-Canal Teeth Affected by Apical Periodontitis, Europian Enodontic Journal, 20231031
    Link to Paper Search Results by DOI
  4. The Bending Strength and Durability of Fiber Post and Core Systems Using a Sleeve., 59(5), 418-424, 201610
  5. Inhibitory effects of ameloblastin on epithelial cell proliferation., Arcives of Oral Biology, 59(8), 835-840, 20140313
    Link to Paper Search Results by DOI
  6. Effects of heat stress and starvation on clonal odontoblast-like cells., Jounral of Endodontics, 37(7), 955-961, 20110524
    Link to Paper Search Results by DOI
  7. Novel biological activity of ameloblastin in enamel matrix derivative., Journal of Applied Oral Science, 23(1), 49-55, 201501
    Link to Paper Search Results by DOI
  8. Effects of Polymer Encapsulated Glial Cell Line-Derived Neurotrophic Factor Secreting Cells on Odontoblast-like Cell Survival, Journal of Regenerative Medicine, 6(3), 2017
    Link to Paper Search Results by DOI
  9. A small nuclear acidic protein (MTI-II, Zn2+-binding protein, parathymosin) attenuates TNF-alpha inhibition of BMP-induced osteogenesis by enhancing accessibility of the Smad4-NF-kappa B p65 complex to Smad binding element, MOLECULAR AND CELLULAR BIOCHEMISTRY, 469(1-2), 133-142, 202006
    Link to Paper Search Results by DOI

Publications such as books

  1. 2024, Handbook for New Clinical Interns in Dentistry, Response to perforation of the floor of the pulpus, 2016, Joint work
  2. 2022, Handbook for New Clinical Interns in Dentistry, Edition for the 2022 Revision of Medical Reimbursement, Response to perforation of the floor of the pulpus, 2022
  3. 2017, Level Up of Endodontic Treatment & Tips, Anatomy of maxillary molars to be considered for root canal treatment, 2017, Joint work, 22-23

Invited Lecture, Oral Presentation, Poster Presentation

  1. Two cases of endodontic treatment on the recessed endodontics in maxillary lateral incisors, Ayaka Miyata, Nishito-Nakayama N, Hirata-Tsuchiya Shizu, Katsuhiro Takeda, Hideki Shiba, The 107th Hiroshima University Dental Society, 2023/11/26, Without Invitation, Japanese
  2. Prognostic study after root canal filling of single root canal teeth with root canals enlarged beyond the ISO standard #55, urutama, D., Hirata-Tsuchiya, Shizu, H., Nishifuji, N., Naruse, T., Kawayanagi, T., Nishihama, S., Miyata, A., Sadaoka, N., Shirawanji, S., Yoshida, K., Nakanishi, J., Takeda, K., Shiba, H, The 157th Annual Meeting of the Japanese Society of Conservative Dentistry, 2022/11/10, Without Invitation, Japanese, Okayama
  3. A case of maxillary central incisor with invasive external resorption of the tooth neck, Katsuhiro Takeda, Satomi Shirawanji, Shizu Tsuchiya, Noriko Nishifuji, Satoshi Shindo, Keiichi Akutagawa, Kazuma Yoshida, Jun Nakanishi, Hideki Shiba, The 152nd Annual Meeting of the Japanese Society of Conservative Dentistry 2020 Spring Meeting, 2020/06/11, Without Invitation, Japanese, Oosaka
  4. Toward the development of biological endodontic therapy, Satomi Shirawanji, Katsuhiro Takeda, Shizu Hirata-Tsuchiya, Satoshi Shindo, Noriko Saito, Keiichi Akutagawa, Kazuma Yoshida, Jun Nakanishi, Hideki Shiba, The 103rd Annual Meeting of the Dental Society of Hiroshima University and the 58th Annual Meeting of the Hiroshima Prefectural Dental Society, 2019/11/17, Without Invitation, Japanese, Hiroshima
  5. NF-kB inhibitor MTI-II is involved in binding of p65-Smad4 complex to Smad binding element, Hirata-Tsuchiya Shizu, Suzuki Shigeki, Okamoto Kazuki, Saito Noriko, Yamada Satoshi, Shiba Hideki., Kitamura Chiaki, The 151st Annual Meeting of the Japanese Society of Conservative Dentistry 2019 Fall Meeting, 2019/11/07, Without Invitation, Japanese, Fukuoka
  6. Toward the development of biological endodontics, Katsuhiro Takeda, Shizu Hirata-Tsuchiya, Satoshi Shindo, Noriko Nishifuji, Keiichi Akutagawa, Takayoshi Nagahara, Hideki Shiba, Western Japan Endodontic Society Hiroshima Workshop 2019, 2019/06/30, Without Invitation, Japanese, Hiroshima
  7. IL-35 suppresses IL-6 and IL-8 production by human periodontal ligament cells induced by IL-17A, Satoshi Shindo, Kazuma Yoshida, Atsushi Nakanishi, Noriko Nishifuji, Shintaro Nagayasu, Naoyo Motoyama, Hideki Shiba, The 149th Annual Meeting of the Japanese Society of Conservative Dentistry, 2018/11/01, Without Invitation, Japanese, Kyoto
  8. Role of platelet-activating factor (PAF) synthase LPCAT2 inhibitors in the development and maintenance of refractory pain, N. Motoyama, K. Morita, S. Nagayasu, S. Hirata-Tsuchiya, N. Nishifuji, T. Shindo, H. Shiba, T. Dohi, The 149th Annual Meeting of the Japanese Society of Conservative Dentistry, 2018 Fall Meeting, 2018/11/01, Without Invitation, Japanese, Kyoto
  9. Effect of Aspirin on BMP-induced osteoblast differentiation, Hirata-Tsuchiya Shizu, Shigeki Suzuki, Noriko Nishifuji, Naoyo Motoyama, Hideki Shiba, The 149th Annual Meeting of the Japanese Society of Conservative Dentistry, 2018/11/01, Without Invitation, Japanese, Kyoto
  10. Identification and antimicrobial susceptibility of bacteria causing apical periodontitis, Chika Kozono, Kazuhisa Ohara, Masae Kitagawa, Ikuko Ogawa, Satoshi Shindo, Noriko Nishifuji, Keiichi Akutagawa, Miyuki Nakaoka, Tomohito Mizuno, Go Fujita, Hideki Shiba, Hidemi Kurihara, The 30th Annual Chugoku-Shikoku District Dental Society, 2018/09/30, Without Invitation, Japanese, Hiroshima
  11. Semaphorin3A inhibits IL-6 and CXCL10 production in TNF-a-stimulated human dental pulp cells., Shindo T., Saito N., Shiba H, The 30th Chugoku and Shikoku Regional Dental Society Meeting, 2018/09/30, Without Invitation, Japanese, Hiroshima
  12. Semaphorin3A suppresses IL-6 and CXCL10 production in TNF-a-stimulated human dental pulp cells., Shindo T., Saito N., Nakanishi M., Yoshida K., Kobuke S., Motoyama N., Nagayasu S., Shiba H., The 148th Meeting of the Japanese Society of Conservative Dentistry 2018 Spring Meeting, 2018/06/14, Without Invitation, Japanese, Yokohama
  13. Investigation of success rate by root tip size in non-surgical endodontic treatment., Hirata-Tsuchiya Shizu, Furutama Daisuke, Nishito-Nakayama H, Naruse Tomoya, Kawayanagi Tomohki, Nishihama S, Miyata Ayaka, Sadaoka N, Shirawanji Satomi, Wang Chutian, Yoshida Kazuma, Nakanishi Jun, Takeda Katsuhiro, Shiba H:, Hirata-Tsuchiya Shizu, Furutama Daisuke, Nishito-Nakayama H, Naruse Tomoya, Kawayanagi Tomohki, Nishihama S, Miyata Ayaka, Sadaoka N, Shirawanji Satomi, Wang Chutian, Yoshida Kazuma, Nakanishi Jun, Takeda Katsuhiro, Shiba H:, The 44th Annual Meeting of the Japanese Endodontic Association The 21st KAE-JEA Joint Meeting, 2023/07/08, Without Invitation, Japanese, Tokyo
  14. Prognostic study after root canal filling of single root canal teeth with root canal enlarged beyond the ISO standard of 55., Furutama D, Hirata-Tsuchiya S, Saito N, Naruse T, Kawayanagi T, Nishihama S, Miyata A, Sadaoka N, Shirawanji S, Yoshida K, Nakanishi J, Takeda K, Shiba H, Furutama D, Hirata-Tsuchiya S, Saito N, Naruse T, Kawayanagi T, Nishihama S, Miyata A, Sadaoka N, Shirawanji S, Yoshida K, Nakanishi J, Takeda K, Shiba H, The 157th Annual Meeting of the Japanese Society of Conservative Dentistry, Without Invitation, Japanese, Tokyo
  15. Effects of glial cell neurotrophic factor secreted from encapsulated cells., Saito Noriko, Saito N, Morotomi T, Washio Y, Hirata-Tsuchiya Sh, Kitamura C, The 13th Annual Meeting and General Meeting of the Japanese Society for Regenerative Dentistry, 2015/08/29, Without Invitation, Japanese, Niigata
  16. Analysis of postoperative pain by endodontic therapy (2), M. Nagayoshi, T. Nishino, Y. Washio, S. Hirata, M. Ichimaru, S. Yoshii, N.Saito, K Kyung, A. Nakagawa, and C. Kitamura, M. Nagayoshi, T. Nishino, Y. Washio, S. Hirata, M. Ichimaru, S. Yoshii, N.Saito, K Kyung, A. Nakagawa, and C. Kitamura, 74th General Meeting of the Kyushu General Assembly, 2014/05/31, Without Invitation, Japanese, Kitakyushu
  17. Ameloblastin inhibits cell proliferation of oral epithelial cells, Saito Noriko, Saito N, Ariyoshi W, Okinaga T, Washio A, Kitamura C, Nishihara T, The 55th Annual Meeting of the Japanese Association for Oral Biology, 2013/09/20, Without Invitation, Japanese, Okayama
  18. Analysis of Postoperative Pain in Endodontic Treatment-Analysis of Factors Influencing the Frequency of Postoperative Pain in Infected Root Canal Treatment., M. Nagayoshi, T. Nishino, A. Washio, S. Hirata, M. Ichimaru, S. Yoshii, N. Saito, S. Yon, A. Nakagawa, C. Kitamura, The 33rd Annual Meeting of the Japanese Endodontic Association, 2012/06/16, Without Invitation, Japanese, Tokyo
  19. Effect of different training methods on the acquisition of treatment techniques: (1) Root canal formation using nickel-titanium files, J. Yano, U. Nishino, T. Morotomi, M. Nagayoshi, A. Washio, S. Hirata, S. Yoshii, N. Saito, T. Kitamura, and M. Terashita, The 132nd Annual Meeting of the Japanese Society of Conservative Dentistry, 2010/06/04, Without Invitation, Japanese, Kumamoto
  20. T. Nishino, J. Yano, T. Morotomi, M. Nagayoshi, A. Washio, S. Hirata, S. Yoshii, N. Saito, T. Kitamura, and M. Terashita, The 70th Annual Meeting of the Kyushu Dental Association, 2010/05/22, Without Invitation, Japanese, Kitakyushu
  21. Effects of different training methods on the learning effect of treatment techniques: (1) Root canal formation using rotary nickel-titanium files., J. Yano, U. Nishino, T. Morotomi, M. Nagayoshi, J. Washio, S. Hirata, S. Yoshii, N. Saito, T. Kitamura, and M. Terashita, The 70th Annual Meeting of the Kyushu Dental Association, 2010/05/22, Without Invitation, Japanese, Kitakyushu
  22. The Influence of Different Practice Methods on the Acquisition of Mirror Skills During Orbital Cavity Formation, The 133rd Annual Meeting of the Japanese Society of Conservative Dentistry, 2010/10/28, Without Invitation, Japanese, Gifu
  23. Effects of Thermal Stimulation on Dentoblast-like Cells under Low Nutritional Conditions, The 133rd Annual Meeting of the Japanese Society of Conservative Dentistry, 2010/10/28, Without Invitation, Japanese, Gifu
  24. Examination of the color tone of Japanese natural teeth using Crystal Eye, 2011/05/28, Without Invitation, Japanese
  25. Analysis of Postoperative Pain in Endodontic Treatment - (1) Frequency of Postoperative Pain during Root Canal Treatment and Effect of Root Canal Puncture on the Appearance of Postoperative Pain, 2011/05/28, Without Invitation, Japanese
  26. Color tone analysis of anterior natural teeth using the Crystal Eye optical colorimeter., The 134th Japanese Society of Conservative Dentistry, 2011/06/09, Without Invitation, Japanese, Chiba
  27. Effect of Intentional Root Canal Stenosis Enlargement during Infected Root Canal Treatment on Postoperative Pain Occurrence and Its Association with Non-odontogenic Pain, The 135th Annual Meeting of the Japanese Society of Conservative Dentistry, Fall 2011, 2011/10/30, Without Invitation, Japanese, The Japanese Society of Conservative Dentistry, Osaka
  28. Analysis of Postoperative Pain in Endodontic Treatment: Influence of Root Canal Stenosis Enlargement on the Frequency of Postoperative Pain in Infected Root Canal Treatment., Annual Report 2023 Japan Endodontic Association, 2011/06/09, Without Invitation, Japanese, Japan Endodontic Association, Nagasaki
  29. Case Reports of endodontic treatment of only the invagination of dens, Ayaka Miyata, Noriko Saito-Nakayama, Shizu Hirata-Tsuchiya, Katsuhiro Takeda, Hideki Shiba, The 107th Annual Meeting of Hiroshima University Dental Society, 2023/11/26, Without Invitation, Japanese, Hiroshima
  30. Endodontic management of dens invaginatus with infected invagination and vital pulp: Two case reports, Noriko Saito-Nakayama, Ayaka Miyata, Shizu Hirata-Tsuchiya, Katsuhiro Takeda, Hideki Shiba, The 159th Meeting of the Japanese Society of Conservative Dentistry, 2023/11/11, Without Invitation, Japanese, Shizuoka
  31. Prognostic study of single root canal teeth with destruction of root apex hole after root canal filling, Saito Noriko, Saito, N., Hirata-Tsuchiya, Sh, D., Furutama, T., Naruse, T., Kawayanagi, T., Nishihama, S., Miyata, A., Sadaoka, N., Shirawachi, S., Yoshida, K., Nakanishi, J., Takeda, K., Shiba, H., The 106th Annual Meeting of Hiroshima University Dental Society, 2022/11/13, Without Invitation, Japanese, Hiroshima
  32. Semaphorin7A promotes inflammatory cytokine secretion from dental pulp cells during inflammation, Saito Noriko, Saito N, Shindo T, Hirata-Tsuchiya Sh, Nakanishi J, Yoshida K, Shiba H, The 149th Annual Meeting of the Japanese Society of Conservative Dentistry, 2018/11/01, Without Invitation, Japanese, Kyoto
  33. Effect of Semaphorin7A on the expression of inflammatory cytokines in human dental pulp cells, Saito Noriko, Saito N, Shindo S, Hirata-Tsuchiya Sh, Nakanishi J, Yoshida K, Shiba H, The 39th Annual Meeting of the Japanese Endodontic Association,, 2018/07/07, Without Invitation, Japanese, Fukuoka
  34. Effects of GDNF and VEGF secreted from cell-encapsulated divices on the viability of dentinoblast-like cells, Saito Noriko, Saito N, Morotomi T, Washio Y, Wahlberg Lars, Emerich Dwaine, Kitamura C, 146th Annual Meeting of the Japanese Society of Conservative Dentistry 2017 Spring Meeting, 2017/06/08, Without Invitation, Japanese, Aomori
  35. Influence of cell-encapsulated devices on the survival of dentinoblast-like cells., Saito Noriko, Saito N, Washio A, Morotomi T, Hanada K, Wahlberg Lars, Emerich Dwaine, Kitamura C, The 144th Annual Meeting of the Japanese Society of Conservative Dentistry 2016 Spring Meeting, 2016/06/25, Without Invitation, Japanese, Tochigi
  36. Effect of cell-encapsulated porous capsules on dentinoblast-like cells., Saito Noriko, Saito N, Washio A, Morotomi T, Hanada K, Kitamura C, The 76th Annual Meeting of the Kyushu Dental Association, 2016/05/28, Without Invitation, Japanese, Kitakyushu
  37. Effect of GDNF secreted from encapsulated cells on dentinoblast-like cell viability., Saito Noriko, Saito N, Morotomi T, Washio Y, Hirata-Tsuchiya Sh, Kitamura C, The 37th Annual Meeting of the Japanese Society for Biomaterial, 2015/11/09, Without Invitation, Japanese, Kyoto
  38. Effects of GDNF-secreting Device on the Viability of Odontoblast-like Cells, Noriko Saito, Noriko Saito, Takahiko Morotomi, Ayako Washio, Kaori Hanada, Shizu Hirata-Tsutiya, Wahlberg Lars, Emerich Dwaine, Chiaki Kitamura, The 142nd Annual Meeting of the Japanese Society of Conservative Dentistry 2015 Spring Meeting, 2015/06/25, Without Invitation, Japanese, Fukuoka
  39. Effect of ameloblastin on cell proliferation of epithelial cells., Saito N, Washio Y, Terashita M, Kitamura T, Saito N, Washio Y, Terashita M, Kitamura T, The 139th Annual Meeting of the Japanese Society of Conservative Dentistry 2013 Fall Meeting, 2013/10/17, Without Invitation, Japanese, Akita
  40. Effect of ameloblastin expression on epithelial cell proliferation., Saito N, Kurama S, Ariyoshi W, Okinaga T, Kitamura C, Yamaguchi K, Nishihara T, 2013/05/18, Without Invitation, Japanese, Kitakyushu
  41. Effect of ameloblastin on epithelial cell proliferation, Saito N,, Saito N, Washio Y, Terashita M, Kitamura C, The 136th Annual Meeting of the Japanese Society of Conservative Dentistry 2012 Spring Meeting, 2012/06/28, Without Invitation, Japanese
  42. Role of ameloblastin in epithelial cells proliferation., Saito N, Saito N, Kuramitsu S, Ariyoshi W, Okinaga T, Kitamura C, Yamaguchi K, Nishihara T, 91th General Session and Exhibition of International Association for Dental Research, 2013/03/20, Without Invitation, English, 91th General Session and Exhibition of International Association for Dental Research, Seattle, USA
  43. Inhibitory effect of ameloblastin on epithelial cells., Saito Noriko, Saito N, Washio A, Kitamura C, Nishihara T, The 9th World Endodontic Congress (International Federation of Endodontic Association, 2013/05/23, Without Invitation, English, nternational Federation of Endodontic Association, Tokyo, Japan

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI Scientific Research(C), Development of a Rapid Test for Bacteria in Root Canals Using Total Adenylate as an Indicator in Endodontics, 2023, 2025
  2. KAKENHI Early-Career Scientists(B), 2016, 2017
  3. KAKENHI, 2014, 2015
  4. KAKENHI Early-Career Scientists, 2019, 2020