KEISHI KANNO
Last Updated :2023/11/01
- Affiliations, Positions
- Hiroshima University Hospital(Medical), Associate Professor
- E-mail
- kkanno
hiroshima-u.ac.jp
- Self-introduction
- I am interested in the basic research to investigate the pathogenesis of liver cirrhosis and nonalcoholic fatty liver diseases.
Basic Information
Major Professional Backgrounds
- 1995/05, 1996/03, Hiroshima University, Hospital, Clinical Resident
- 1996/04, 1996/09, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Clinical Resident
- 1996/10, 1997/03, Hiroshima University, Hospital, Clinical Resident
- 1997/04, 2000/03, Akitsu Prefectural Hospital, Doctor
- 2000/04, 2004/10, Hiroshima University, Hospital, medical staff
- 2004/11, 2006/10, Brigam and Women's Hospital, Harvard Medical School, Research Fellow
- 2006/11/14, 2007/03/31, Hiroshima University Hospital, Research Associate
- 2007/04/01, 2013/03/31, Hiroshima University, Assistant Professor
- 2013/04/01, 2018/03/31, Hiroshima University Hospital, Lecturer
- 2018/04/01, Hiroshima University, Hospital, Associate Professor
Academic Degrees
- Doctor of Philosophy in Medical Science, Hiroshima University
Research Fields
- Medicine,dentistry, and pharmacy;Clinical internal medicine;Gastroenterology
Research Keywords
- Hepatic fibrosis
- Hepatic lipid metabolism
- Extracellular matrix
- Renin-angiotensin system
Educational Activity
Course in Charge
- 2023, Undergraduate Education, Second Semester, Human Relations
- 2023, Undergraduate Education, Intensive, Practice for medical research
- 2023, Undergraduate Education, Intensive, Practice of Medicine I
- 2023, Undergraduate Education, Intensive, Practice of Medicine II
- 2023, Graduate Education (Master's Program) , First Semester, Research on Public Health (Health Service Administration)
- 2023, Graduate Education (Master's Program) , Second Semester, Lecture on Practice of General Medicine
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on General Medicine
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on General Medicine
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on General Medicine
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on General Medicine
Research Activities
Academic Papers
- Plant-Derived Lactobacillus paracasei IJH-SONE68 Improves the Gut Microbiota Associated with Hepatic Disorders: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial, NUTRIENTS, 14(21), 202211
- Clinical utility of computed tomography-based evaluation of trunk muscles in primary sclerosing cholangitis, JAPANESE JOURNAL OF RADIOLOGY, 40(10), 1053-1060, 202210
- Depletion of hepatic stellate cells inhibits hepatic steatosis in mice, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 37(10), 1946-1954, 202210
- A Case of Bazex Syndrome., Intern Med, 61(3), 443-444, 2021
- Case of non-secretory multiple myeloma eventually diagnosed by F-18-FDG PET/CT, CLINICAL CASE REPORTS, 10(6), 202206
- In vitro Suppression of SARS-CoV-2 Infection by Existing Kampo Formulas and Crude Constituent Drugs Used for Treatment of Common Cold Respiratory Symptoms, FRONTIERS IN PHARMACOLOGY, 13, 20220329
- Exopolysaccharide Produced by Plant-Derived Lactobacillus plantarum SN35N Exhibits Antiviral Activity, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 44(12), 1886-1890, 202112
- Advanced glycation end products enhance the proliferation and activation of hepatic stellate cells, JOURNAL OF GASTROENTEROLOGY, 43(4), 298-304, 2008
- Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 23(7), E198-E206, 200807
- Deletion of angiotensin II type I receptor reduces hepatic steatosis, JOURNAL OF HEPATOLOGY, 50(6), 1226-1235, 200906
- Lack of adiponectin promotes formation of cholesterol gallstones in mice, Biochem Biophys Res Commun, 399(3), 352-358, 20100827
- Bach1 gene ablation reduces steatohepatitis in mouse MCD diet model, J Clin Biochem Nutr, 48(2), 161-166, 20110302
- Dose-dependent conjugation of sulfobromophthalein and hepatic transit time in bile fistula rats Role of the microtubule-dependent vesicle pathway, Dig Dis Sci, 46(6), 1285-1289, 20010401
- AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl(4), Biochem. Biophys. Res. Common, 308(1), 177-183, 20030401
- Unique reciprocal changes of hepatcellular membrane transporter expression and fluidity in rats with selective biliary obstruction, Hepatol Res, 26(2), 157-163, 20030401
- Angiotensin II participates in hepatic inflammation and fibrosis through MCP-1 expression, Dig Dis Sci, 50(5), 942-8, 20050501
- Phospholipid alterations in hepatocyte membranes and transporter protein changes in cholestatic rat model, DIGESTIVE DISEASES AND SCIENCES, 46(10), 2089-2097, 200110
- Impaired gallbladder mucosal function in aged gallstone patients suppresses gallstone recurrence after successful extracorporeal shockwave lithotripsy, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 18(2), 157-161, 20030201
- Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 346(3), 658-664, 20060804
- Spontaneously hnypertensive rats develop pronounced hepatic steatosis induced by cholie-deficient diet: Evidence for hypertension as a potential enhancer in non-alcoholic steatohepatitis, HEPATOLOGY RESEARCH, 42(3), 310-320, 201203
- Nutritional factors (nutritional aspects) in biliary disorders: Bile acid and lipid metabolism in gallstone diseases and pancreaticobiliary maljunction, J Gastroenterol Hepatol, 28, 103-107, 20131201
- Partial characterization of proapoptotic action of biliary deteriorated lipids on biliary epithelial cells in pancreaticobiliary diseases, J Hepatobiliary Pancreat Sci, 21(3), 212-218, 201403
- Report on the 2013 national cholelithiasis survey in Japan, J Hepatobiliary Pancreat Sci, 22(5), 392-395, 201505
- Clinical evaluation of ezetimibe on bile lithogenicity in humans: Use of transnasal endoscopy for bile sampling, HEPATOLOGY RESEARCH, 45(6), 693-697, 201506
- Cholangiocyte senescence caused by lysophosphatidylcholine as a potential implication in carcinogenesis, J Hepatobiliary Pancreat Sci, 22(9), 675-682, 201509
- Long-term administration of a Niemann-Pick C1-like 1 inhibitor, ezetimibe, does not worsen bile lithogenicity in dyslipidemic patients with hepatobiliary diseases, J Hepatobiliary Pancreat Sci,, 23(2), 125-131, 2016
- Ursodeoxycholic acid after bile duct stone removal and risk factors for recurrence: a randomized trial, J Hepatobiliary Pancreat Sci, 23(2), 132-136, 2016
- Enhancing hepatic fibrosis in spontaneously hypertensive rats fed a choline-deficient diet: a follow-up report on long-term effects of oxidative stress in non-alcoholic fatty liver disease, J Hepatobiliary Pancreat Sci, 23(5), 260-269, 2016
- Systemic Inflammatory Syndrome Associated with a Case of Jugular Paraganglioma, Intern Med, 55(15), 2105-2108, 2016
- Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via alpha(v) integrin interaction, J Gastroenterol, 51(12), 1161-1174, 2016
- Five Cases of Familial Mediterranean Fever in Japan: The Relationship with MEFV Mutations., Intern Med, 57(16), 2425-2429, 2018
- Primary Signet Ring Cell Carcinoma of Rectum Diagnosed by Boring Biopsy in Combination with Endoscopic Mucosal Resection., Case Rep Med, 2018
- Acute respiratory distress syndrome caused by salicylate intoxication., Clinical Case Reports, 6(9), 1905-1906, 2018
- Periostin promotes malignant potential by induction of epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma., Hepatol Commun, 1(10), 1099-1109, 2017
- Key diagnostic features of fever of unknown origin: Medical history and physical findings, J Gen Fam Med, 18(3), 131-134, 2017
- Protective effect of phosphatidylcholine on lysophosphatidylcholine-induced cellular senescence in cholangiocyte, J Hepatobiliary Pancreat Sci, 26(12), 568-577, 2019
- Decrease in major secondary bile acid, hyodeoxycholic acid, was the main alteration in hepatic bile acid compositions in a hypertensive nonalcoholic fatty liver disease model, J Hepatobiliary Pancreat Sci., 26(12), 557-567, 2019
- A case of giant cell arteritis simultaneously diagnosed with chronic subdural hematoma, Clin Case Rep, 7(12), 2534-2538, 2019
- A possible therapeutic agent for pulmonary fibrosis: Antibody against integrin alpha 8 beta 1, EUROPEAN RESPIRATORY JOURNAL, 42, 2013
- Hypertension enhances hepatic steatosis through oxidative stress associated with down-regulated expressions of LXR and FXR; Implication to the future strategy for non-alcoholic fatty liver diseases (NAFLD) by nuclear receptor ligands, HEPATOLOGY, 56, 848A-848A, 2012
- LYSOPHOSPHATIDYLCHOLINE INDUCES APOPTOTIC CELL DEATH IN BILIARY EPITHELIAL CELL: IMPLICATION TO BILIARY ONCOGENESIS BASED UPON CHOLANGITIS AND/OR PANCREATICOBILIARY MALJUNCTION, HEPATOLOGY, 54, 769A-769A, 2011
- An essential role of hepatic cholesterol and bile acid metabolism mediated by nuclear receptors in the development of hypertension-associated non-alcoholic steatohepatitis, J Gastroenterol Hepatol, 31, 356-356, 2016
- Protective effect of phosphatidylcholine against lysophosphatidylcholine-induced cytotoxicity in cholangiocytes: a potential therapeutic target in cholangiocarcinoma, HEPATOLOGY, 66, 941A-941A, 2017
- Hdca Species Decreased Largely in Hepatic Bile Acid Compositions of NAFLD Animal Model with Hypertension, HEPATOLOGY, 68, 822A-822A, 2018
- Periostin Antisense Oligonucleotide Prevents Hepatic Steatosis and Fibrosis in Mice: A Novel Strategy for Nonalcoholic Steatohepatitis Treatment., HEPATOLOGY, 68, 1008A-1008A, 2018
- An Atypical Case of Non-asthmatic Eosinophilic Granulomatosis with Polyangiitis Finally Diagnosed by Tissue Biopsy, Intern Med, 58(6), 871-875, 2019
- Successful Treatment of Acute Chest Syndrome with Manual Exchange Transfusion in a Patient with Sickle Beta(+)-thalassemia, Intern Med, 58(11), 1629-1634, 2019
- Toxocariasis Suspected of Having Infiltrated Directly from the Liver to the Lung through the Diaphragm, Intern Med, 58(18), 2737-2741, 2019
- MOLECULAR MECHANISMS IN WHICH PERIOSTIN INDUCES HEPATIC STEATOSIS IN VIVO AND IN VITRO, HEPATOLOGY, 70, 1286A-1286A, 2019
- Clinical evaluation of ezetimibe on bile lithogenicity in humans: Use of transnasal endoscopy for bile sampling., Hepatology research : the official journal of the Japan Society of Hepatology, 45(6), 2015
- Erythromelalgic Symptoms in Left Subclavian Artery Stenosis., Intern Med, 59(9), 1235-1236, 2020
- Primary sclerosing cholangitis (global type, stage II) : a case of effective ursodeoxycholic acid therapy, 15(1), 49-53, 20010328
- Lysophosphatidylcholine induces apoptosis in human bile duct carcinoma cell HuCCT-1, 25(4), 637-644, 20111031
- A CASE OF MUCOSAL ADENOCARCINOMA IN THE LOWER ESOPHAGUS, ARISING FROM CARDIAC GLANDS, GASTROENTEROLOGICAL ENDOSCOPY, 42(5), 962-967, 20000520
- The modality of non-surgical treatments for gallstones : Factors affecting gallstone recurrence after extracorporeal shock wave lithotripsy (ESWL) and post-therapeutic symptoms, 18(2), 108-113, 20040531
- Pathogenesis and treatment of gallstone diseases, Nihon Naika Gakkai Zasshi, 102(9), 2460-2467, 20130910
- A nation-wide survey of hepatolithiasis, Tando, 27(5), 788-794, 2013
- Analysis of the Risk Factor for Gallstone, Tando, 29(2), 219-225, 2015
- Clinical management and prognosis of sclerosing cholangitis, Tando, 30(5), 911-916, 2016
- Periostin antisense oligonucleotide prevents hepatic steatosis and fibrosis in a mouse model of non-alcoholic steatohepatitis, J Gastroenterol Hepatol, 2020
- Clinical characteristics of aeromonas bacteremia at Hiroshima University Hospital: Literature review and therapeutic proposal, JHGM, 2(3), 62-70, 2020
- Two patients with Paget-schroetter syndrome that were successfully diagnosed by doppler ultrasonography: Case studies with a literature review, Intern Med, 59(20), 2623-2627, 2020
- Effect of Salacia oblonga extract on blood pressure in nigh-normal blood pressure or grade I hypertension subjects: a dose-comparison, pilot study, Pharmacometrics, 98(3/4), 35-41, 2020
- Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma, J Cancer Res Clin Oncol, 146(12), 3255-3268, 2020
- A case of Fusobacterium nucleatum infection causing thrombophlebitis of the cavernous sinus diagnosed by lung abscess sampling under video-assisted thoracic surgery, JHGM, 2(5), 120-126, 2020
- Reduction of fatigue and anger-hostility by the oral administration of 5-aminolevulinic acid phosphate: a randomized, double-blind, placebo-controlled, parallel study, Sci Rep, 10(1), 16004, 20200929
- Lactobacillus Plantarum SN13T cells improve hepatic dysfunction and fecal microbiota: A randomized pilot study, Adv Exp Med Biol, 2020
- Induced hepatic stellate cell integrin, alpha 8 beta 1, enhances cellular contractility and TGF beta activity in liver fibrosis, JOURNAL OF PATHOLOGY, 253(4), 366-373, 202104
- Reduction of fatigue and anger-hostility by the oral administration of 5-aminolevulinic acid phosphate: a randomized, double-blind, placebo-controlled, parallel study, SCIENTIFIC REPORTS, 10(1), 20200929
- Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma, INTERNAL MEDICINE, 60(8), 1311-1315, 2021
- Plant-Derived Lactobacillus paracasei IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, NUTRIENTS, 13(11), 4022, 202111
- The Exopolysaccharide Produced by Lactobacillus paracasei IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS-Induced Ulcerative Colitis, MICROORGANISMS, 9(11), 202111
Invited Lecture, Oral Presentation, Poster Presentation
- Depletion of hepatic stellate cells reduces hepatic steatosis., Kawahara A, Kanno K, Uwada Y, Yonezawa S, Ito M., 123th Annual Meeting, American Gastroenterological Association, 2022/05, Without Invitation, English, American Gastroenterological Association
- A study on the use of Long-lasting Insecticidal Nets (LLINs) for Malaria prevention among Indonesian 5-years-old population, Gunara RA, Widawati M, Miyamori D, Kanno K, Ito M, ICPS2020, 2020/10, Without Invitation, English, Universitas Airlangga, Surabaya, Indonesia
External Funds
Acceptance Results of Competitive Funds
- KAKENHI, Activated hepatic stellate cell specific antibody that attenuates liver fibrosis: mechanism of action and therapeutic use, 2012, 2013
- KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2020