Last Updated :2023/01/06

Affiliations, Positions
Hiroshima University Hospital(Medical), Associate Professor
I am interested in the basic research to investigate the pathogenesis of liver cirrhosis and nonalcoholic fatty liver diseases.

Basic Information

Major Professional Backgrounds

  • 1995/05, 1996/03, Hiroshima University, Hospital, Clinical Resident
  • 1996/04, 1996/09, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Clinical Resident
  • 1996/10, 1997/03, Hiroshima University, Hospital, Clinical Resident
  • 1997/04, 2000/03, Akitsu Prefectural Hospital, Doctor
  • 2000/04, 2004/10, Hiroshima University, Hospital, medical staff
  • 2004/11, 2006/10, Brigam and Women's Hospital, Harvard Medical School, Research Fellow
  • 2006/11/14, 2007/03/31, Hiroshima University Hospital, Research Associate
  • 2007/04/01, 2013/03/31, Hiroshima University, Assistant Professor
  • 2013/04/01, 2018/03/31, Hiroshima University Hospital, Lecturer
  • 2018/04/01, Hiroshima University, Hospital, Associate Professor

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Gastroenterology

Research Keywords

  • Hepatic fibrosis
  • Hepatic lipid metabolism
  • Extracellular matrix
  • Renin-angiotensin system

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Second Semester, Human Relations
  2. 2022, Undergraduate Education, Intensive, Practice for medical research
  3. 2022, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2022, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2022, Graduate Education (Master's Program) , First Semester, Research on Public Health (Health Service Administration)
  6. 2022, Graduate Education (Master's Program) , Second Semester, Lecture on Practice of General Medicine
  7. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on General Medicine
  8. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on General Medicine
  9. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on General Medicine
  10. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on General Medicine

Research Activities

Academic Papers

  1. A Case of Bazex Syndrome., Intern Med, 61(3), 443-444, 2021
  2. Exopolysaccharide Produced by Plant-Derived Lactobacillus plantarum SN35N Exhibits Antiviral Activity, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 44(12), 1886-1890, 202112
  3. Advanced glycation end products enhance the proliferation and activation of hepatic stellate cells, JOURNAL OF GASTROENTEROLOGY, 43(4), 298-304, 2008
  4. Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 23(7), E198-E206, 200807
  5. Deletion of angiotensin II type I receptor reduces hepatic steatosis, JOURNAL OF HEPATOLOGY, 50(6), 1226-1235, 200906
  6. Lack of adiponectin promotes formation of cholesterol gallstones in mice, Biochem Biophys Res Commun, 399(3), 352-358, 20100827
  7. Bach1 gene ablation reduces steatohepatitis in mouse MCD diet model, J Clin Biochem Nutr, 48(2), 161-166, 20110302
  8. Dose-dependent conjugation of sulfobromophthalein and hepatic transit time in bile fistula rats Role of the microtubule-dependent vesicle pathway, Dig Dis Sci, 46(6), 1285-1289, 20010401
  9. AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl(4), Biochem. Biophys. Res. Common, 308(1), 177-183, 20030401
  10. Unique reciprocal changes of hepatcellular membrane transporter expression and fluidity in rats with selective biliary obstruction, Hepatol Res, 26(2), 157-163, 20030401
  11. Angiotensin II participates in hepatic inflammation and fibrosis through MCP-1 expression, Dig Dis Sci, 50(5), 942-8, 20050501
  12. Phospholipid alterations in hepatocyte membranes and transporter protein changes in cholestatic rat model, DIGESTIVE DISEASES AND SCIENCES, 46(10), 2089-2097, 200110
  13. Impaired gallbladder mucosal function in aged gallstone patients suppresses gallstone recurrence after successful extracorporeal shockwave lithotripsy, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 18(2), 157-161, 20030201
  14. Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 346(3), 658-664, 20060804
  15. Spontaneously hnypertensive rats develop pronounced hepatic steatosis induced by cholie-deficient diet: Evidence for hypertension as a potential enhancer in non-alcoholic steatohepatitis, HEPATOLOGY RESEARCH, 42(3), 310-320, 201203
  16. Nutritional factors (nutritional aspects) in biliary disorders: Bile acid and lipid metabolism in gallstone diseases and pancreaticobiliary maljunction, J Gastroenterol Hepatol, 28, 103-107, 20131201
  17. Partial characterization of proapoptotic action of biliary deteriorated lipids on biliary epithelial cells in pancreaticobiliary diseases, J Hepatobiliary Pancreat Sci, 21(3), 212-218, 201403
  18. Report on the 2013 national cholelithiasis survey in Japan, J Hepatobiliary Pancreat Sci, 22(5), 392-395, 201505
  19. Clinical evaluation of ezetimibe on bile lithogenicity in humans: Use of transnasal endoscopy for bile sampling, HEPATOLOGY RESEARCH, 45(6), 693-697, 201506
  20. Cholangiocyte senescence caused by lysophosphatidylcholine as a potential implication in carcinogenesis, J Hepatobiliary Pancreat Sci, 22(9), 675-682, 201509
  21. Long-term administration of a Niemann-Pick C1-like 1 inhibitor, ezetimibe, does not worsen bile lithogenicity in dyslipidemic patients with hepatobiliary diseases, J Hepatobiliary Pancreat Sci,, 23(2), 125-131, 2016
  22. Ursodeoxycholic acid after bile duct stone removal and risk factors for recurrence: a randomized trial, J Hepatobiliary Pancreat Sci, 23(2), 132-136, 2016
  23. Enhancing hepatic fibrosis in spontaneously hypertensive rats fed a choline-deficient diet: a follow-up report on long-term effects of oxidative stress in non-alcoholic fatty liver disease, J Hepatobiliary Pancreat Sci, 23(5), 260-269, 2016
  24. Systemic Inflammatory Syndrome Associated with a Case of Jugular Paraganglioma, Intern Med, 55(15), 2105-2108, 2016
  25. Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via alpha(v) integrin interaction, J Gastroenterol, 51(12), 1161-1174, 2016
  26. Five Cases of Familial Mediterranean Fever in Japan: The Relationship with MEFV Mutations., Intern Med, 57(16), 2425-2429, 2018
  27. Primary Signet Ring Cell Carcinoma of Rectum Diagnosed by Boring Biopsy in Combination with Endoscopic Mucosal Resection., Case Rep Med, 2018
  28. Acute respiratory distress syndrome caused by salicylate intoxication., Clinical Case Reports, 6(9), 1905-1906, 2018
  29. Periostin promotes malignant potential by induction of epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma., Hepatol Commun, 1(10), 1099-1109, 2017
  30. Key diagnostic features of fever of unknown origin: Medical history and physical findings, J Gen Fam Med, 18(3), 131-134, 2017
  31. Protective effect of phosphatidylcholine on lysophosphatidylcholine-induced cellular senescence in cholangiocyte, J Hepatobiliary Pancreat Sci, 26(12), 568-577, 2019
  32. Decrease in major secondary bile acid, hyodeoxycholic acid, was the main alteration in hepatic bile acid compositions in a hypertensive nonalcoholic fatty liver disease model, J Hepatobiliary Pancreat Sci., 26(12), 557-567, 2019
  33. A case of giant cell arteritis simultaneously diagnosed with chronic subdural hematoma, Clin Case Rep, 7(12), 2534-2538, 2019
  34. A possible therapeutic agent for pulmonary fibrosis: Antibody against integrin alpha 8 beta 1, EUROPEAN RESPIRATORY JOURNAL, 42, 2013
  35. Hypertension enhances hepatic steatosis through oxidative stress associated with down-regulated expressions of LXR and FXR; Implication to the future strategy for non-alcoholic fatty liver diseases (NAFLD) by nuclear receptor ligands, HEPATOLOGY, 56, 848A-848A, 2012
  37. An essential role of hepatic cholesterol and bile acid metabolism mediated by nuclear receptors in the development of hypertension-associated non-alcoholic steatohepatitis, J Gastroenterol Hepatol, 31, 356-356, 2016
  38. Protective effect of phosphatidylcholine against lysophosphatidylcholine-induced cytotoxicity in cholangiocytes: a potential therapeutic target in cholangiocarcinoma, HEPATOLOGY, 66, 941A-941A, 2017
  39. Hdca Species Decreased Largely in Hepatic Bile Acid Compositions of NAFLD Animal Model with Hypertension, HEPATOLOGY, 68, 822A-822A, 2018
  40. Periostin Antisense Oligonucleotide Prevents Hepatic Steatosis and Fibrosis in Mice: A Novel Strategy for Nonalcoholic Steatohepatitis Treatment., HEPATOLOGY, 68, 1008A-1008A, 2018
  41. An Atypical Case of Non-asthmatic Eosinophilic Granulomatosis with Polyangiitis Finally Diagnosed by Tissue Biopsy, Intern Med, 58(6), 871-875, 2019
  42. Successful Treatment of Acute Chest Syndrome with Manual Exchange Transfusion in a Patient with Sickle Beta(+)-thalassemia, Intern Med, 58(11), 1629-1634, 2019
  43. Toxocariasis Suspected of Having Infiltrated Directly from the Liver to the Lung through the Diaphragm, Intern Med, 58(18), 2737-2741, 2019
  45. Clinical evaluation of ezetimibe on bile lithogenicity in humans: Use of transnasal endoscopy for bile sampling., Hepatology research : the official journal of the Japan Society of Hepatology, 45(6), 2015
  46. Erythromelalgic Symptoms in Left Subclavian Artery Stenosis., Intern Med, 59(9), 1235-1236, 2020
  47. Primary sclerosing cholangitis (global type, stage II) : a case of effective ursodeoxycholic acid therapy, 15(1), 49-53, 20010328
  48. Lysophosphatidylcholine induces apoptosis in human bile duct carcinoma cell HuCCT-1, 25(4), 637-644, 20111031
  50. The modality of non-surgical treatments for gallstones : Factors affecting gallstone recurrence after extracorporeal shock wave lithotripsy (ESWL) and post-therapeutic symptoms, 18(2), 108-113, 20040531
  51. Pathogenesis and treatment of gallstone diseases, Nihon Naika Gakkai Zasshi, 102(9), 2460-2467, 20130910
  52. A nation-wide survey of hepatolithiasis, Tando, 27(5), 788-794, 2013
  53. Analysis of the Risk Factor for Gallstone, Tando, 29(2), 219-225, 2015
  54. Clinical management and prognosis of sclerosing cholangitis, Tando, 30(5), 911-916, 2016
  55. Periostin antisense oligonucleotide prevents hepatic steatosis and fibrosis in a mouse model of non-alcoholic steatohepatitis, J Gastroenterol Hepatol, 2020
  56. Clinical characteristics of aeromonas bacteremia at Hiroshima University Hospital: Literature review and therapeutic proposal, JHGM, 2(3), 62-70, 2020
  57. Two patients with Paget-schroetter syndrome that were successfully diagnosed by doppler ultrasonography: Case studies with a literature review, Intern Med, 59(20), 2623-2627, 2020
  58. Effect of Salacia oblonga extract on blood pressure in nigh-normal blood pressure or grade I hypertension subjects: a dose-comparison, pilot study, Pharmacometrics, 98(3/4), 35-41, 2020
  59. Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma, J Cancer Res Clin Oncol, 146(12), 3255-3268, 2020
  60. A case of Fusobacterium nucleatum infection causing thrombophlebitis of the cavernous sinus diagnosed by lung abscess sampling under video-assisted thoracic surgery, JHGM, 2(5), 120-126, 2020
  61. Reduction of fatigue and anger-hostility by the oral administration of 5-aminolevulinic acid phosphate: a randomized, double-blind, placebo-controlled, parallel study, Sci Rep, 10(1), 16004, 20200929
  62. Lactobacillus Plantarum SN13T cells improve hepatic dysfunction and fecal microbiota: A randomized pilot study, Adv Exp Med Biol, 2020
  63. Induced hepatic stellate cell integrin, alpha 8 beta 1, enhances cellular contractility and TGF beta activity in liver fibrosis, JOURNAL OF PATHOLOGY, 253(4), 366-373, 202104
  64. Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma, INTERNAL MEDICINE, 60(8), 1311-1315, 2021
  65. Plant-Derived Lactobacillus paracasei IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, NUTRIENTS, 13(11), 4022, 202111
  66. The Exopolysaccharide Produced by Lactobacillus paracasei IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS-Induced Ulcerative Colitis, MICROORGANISMS, 9(11), 202111

Invited Lecture, Oral Presentation, Poster Presentation

  1. A study on the use of Long-lasting Insecticidal Nets (LLINs) for Malaria prevention among Indonesian 5-years-old population, Gunara RA, Widawati M, Miyamori D, Kanno K, Ito M, ICPS2020, 2020/10, Without Invitation, English, Universitas Airlangga, Surabaya, Indonesia

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, Activated hepatic stellate cell specific antibody that attenuates liver fibrosis: mechanism of action and therapeutic use, 2012, 2013
  2. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2020