YUKI IMAOKA

Last Updated :2024/05/08

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Assistant Professor (Special Appointment)
E-mail
yimaokahiroshima-u.ac.jp
Self-introduction
We conduct the basic and clinical research on cancer immunity and transplantation immunity among the hepato-biliary-pancreas/transplant surgery. The content is to elucidate the mechanism of the decline in liver-resident natural killer cell activity after hepatectomy and to develop a new treatment. I am also involved in research on regenerative medicine that uses immune cells after liver surgery and liver transplantation. In addition, we conduct to reveal the effects of lifestyle-related diseases such as arteriosclerosis, diabetes, and dyslipidemia on intrahepatic immunity.

Basic Information

Major Professional Backgrounds

  • 2022/05/01, Graduate School of Biomedical and Health Sciences, Hiroshima University, Special appointment Assistant Professor
  • 2022/04/01, Graduate School of Biomedical and Health Sciences, Hiroshima University, Research Associate
  • 2021/04/01, Hiroshima University Hospital, Clinical Fellow
  • 2016/04/01, Innoshima Ishikai Hospital, Clinical Fellow
  • 2015/04/01, Department of Gastroenterological and Transplant Surgery, Hiroshima University, Clinical Fellow
  • 2012/04/01, Hiroshima Prefecture Hospital, Clinical Fellow
  • 2010/04/01, Kure Kyosai Hospital, Clinical trainee

Educational Backgrounds

  • Hiroshima University, 2004, 2010
  • Hiroshima University, Graduate School of Biomedical and Health Sciences, 2017, 2021

Academic Degrees

  • Hiroshima University

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Intensive, Introduction to clinical clerkship

Research Activities

Academic Papers

  1. Impact of a new liver immune status index among patients with hepatocellular carcinoma after initial hepatectomy, ANNALS OF GASTROENTEROLOGICAL SURGERY, 7(6), 987-996, 202311
  2. Breaking distance barriers in liver transplantation: Risk factors and outcomes of long-distance liver grafts, Surgery, 20231116
  3. The short and long-term prognostic influences of liver grafts with high bilirubin levels at the time of organ recovery., Clin Transplant., 20231009
  4. Has the risk of liver re-transplantation improved over the two decades?, Clin Transplant., 20230929
  5. The aryl hydrocarbon receptor maintains antitumor activity of liver resident natural killer cells after partial hepatectomy in C57BL/6J mice., Cancer Med, 12(19), 19821-19837, 20231012
  6. Overcoming the hurdles of steatotic grafts in liver transplantation: Insights into survival and prognostic factors., Liver Transpl., 20230825
  7. Adoptive immunotherapy with natural killer cells from peripheral blood CD34+ stem cells to prevent hepatocellular carcinoma recurrence after curative hepatectomy: a study protocol for an open-label, single-arm phase I study., BMJ open, 12(11), 2022
  8. Impact of Abdominal Aortic Calcification After Major Hepatobiliary Pancreatic Surgery: A Retrospective Cohort Study., Anticancer research, 42(12), 2022
  9. Effect of abdominal aortic calcification on the prognosis and recurrence of colorectal cancer stages II-III: A retrospective cohort study., International journal of colorectal disease, 38(1), 2023
  10. The Current State of Liver Transplantation for Colorectal Liver Metastases in the United States: A Call for Standardized Reporting., Annals of surgical oncology, 2023
  11. Protection From Second Warm Ischemic Injury Using a Thermal Barrier Bag in Kidney Transplantation., Transplantation direct, 9(3), 2023
  12. Evaluating the outcomes of donor-recipient age differences in young adults undergoing liver transplantation., Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2023
  13. Impact of Geriatric Nutritional Risk Index After Initial Hepatectomy for Hepatocellular Carcinoma: a Retrospective Cohort Study with the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)., Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2023
  14. Effectiveness of Thermal Barrier Bag for Prolonged Vascular Anastomosis in Kidney Transplantation., Transplantation proceedings, 2023
  15. Surgery-related disseminated intravascular coagulation predicts postoperative complications, BMC SURGERY, 23(1), 20230411
  16. Effect of abdominal aortic calcification on the prognosis and recurrence of colorectal cancer stages II-III: A retrospective cohort study, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 38(1), 20230121
  17. Protection From Second Warm Ischemic Injury Using a Thermal Barrier Bag in Kidney Transplantation, TRANSPLANTATION DIRECT, 9(3), 202303
  18. Impact of Abdominal Aortic Calcification After Major Hepatobiliary Pancreatic Surgery: A Retrospective Cohort Study, ANTICANCER RESEARCH, 42(12), 5983-5989, 202212
  19. Adoptive immunotherapy with natural killer cells from peripheral blood CD34(+) stem cells to prevent hepatocellular carcinoma recurrence after curative hepatectomy: a study protocol for an open-label, single-arm phase I study, BMJ OPEN, 12(11), 202211
  20. Acute portal hypertension using portal vein ligation abrogates TRAIL expression of liver-resident NK cells, HEPATOLOGY COMMUNICATIONS, 6(9), 2551-2564, 202209
  21. Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study., Annals of gastroenterological surgery, 6(1), 2022
  22. Adoptive immunotherapy overcomes genetic susceptibility to bloodstream infections due to fc-gamma receptor polymorphisms after liver transplantation., American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2022
  23. Acute portal hypertension using portal vein ligation abrogates TRAIL expression of liver-resident NK cells, Hepatology Communications, 6(9), 2551-2564, 20220901
  24. Clinical significance of advanced lung cancer inflammation index, a nutritional and inflammation index, in gastric cancer patients after surgical resection: A propensity score matching analysis., Clinical nutrition (Edinburgh, Scotland), 40(3), 2021
  25. Impact on biliary complications of donor abdominal aortic calcification among living donor liver transplantation: a retrospective study, Transplant International, 33(12), 1745-1753, 20201201
  26. Impact of Abdominal Aortic Calcification Among Liver Transplantation Recipients., Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 25(1), 2019
  27. Risk Factors for Refractory Ascites After Living Donor Liver Transplant., Transplantation proceedings, 51(5), 2019
  28. Management of Refractory Ascites for Liver Transplant Candidates: A Novel Cell-free and Concentrated Ascites Reinfusion Therapy., Transplantation proceedings, 51(8), 2019
  29. Usefulness of Totally Implantable Central Venous Access Devices in Elderly Patients: A Retrospective Study., Annals of nutrition & metabolism, 72(2), 2018
  30. Rate of Clinical Complete Response for 1 Year or More in Bone-Metastatic Breast Cancer after Comprehensive Treatments including Autologous Formalin-Fixed Tumor Vaccine., International journal of breast cancer, 2018, 2018
  31. Hepatic irradiation persistently eliminates liver resident NK cells., PloS one, 13(6), 2018
  32. Independent risk factors that predict bile leakage after hepatectomy for hepatocellular carcinoma: Cohort study., International journal of surgery (London, England), 57, 2018
  33. Polymorphisms in TRAIL predict long-term survival and extrahepatic recurrence following initial hepatectomy for hepatocellular carcinoma., Journal of hepato-biliary-pancreatic sciences, 25(8), 2018
  34. Adrenal failure due to bilateral adrenal metastasis of rectal cancer: A case report., International journal of surgery case reports, 31, 2017
  35. Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity and modified Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity for the mortality prediction among nonagenarians undergoing emergency surgery., The Journal of surgical research, 210, 2017
  36. Perforation of the gallbladder in a patient with acute cytomegalovirus cholecystitis shortly following renal transplantation, Transplant Infectious Disease, 19(5), 20171001
  37. Long-lasting complete response status of advanced stage IV gall bladder cancer and colon cancer after combined treatment including autologous formalin-fixed tumor vaccine: two case reports., World journal of surgical oncology, 15(1), 2017
  38. Intratumoral heterogeneity of programmed cell death ligand-1 expression is common in lung cancer., PloS one, 12(10), 2017
  39. Hybrid Surgery for Portosystemic Encephalopathy in a Patient with Liver Cirrhosis: a case report., Hiroshima journal of medical sciences, 66(1), 2017
  40. Elective laparoscopic deroofing to treat the spontaneous rupture of a large simple liver cyst: a case report., Surgical case reports, 2(1), 2016
  41. Validity of predictive factors of acute complicated appendicitis., World journal of emergency surgery : WJES, 11, 2016
  42. [A case of triple-negative breast cancer responding to multidisciplinary treatment containing bevacizumab]., Gan to kagaku ryoho. Cancer & chemotherapy, 41(4), 2014
  43. [Estimation of peritoneal dissemination in patients with unresectable advanced or recurrent colorectal cancer who underwent curative resection after combination chemotherapy]., Gan to kagaku ryoho. Cancer & chemotherapy, 41(5), 2014

Awards

  1. 2024, Academic Surgical Congress (ASC) Travel Grant, 日本外科学会
  2. 2024, Top Scoring Abstract Winner, The Society of University Surgeons (SUS)
  3. 2023, TTS Scientific Congress Award, The Transplantation Society (TTS)