MASAHIRO OOHIRA

Last Updated :2025/01/08

Affiliations, Positions
Hiroshima University Hospital, Assistant Professor
E-mail
mohirahiroshima-u.ac.jp
Self-introduction
I am researching cancer immunity and transplantation immunity in hepatobiliary, pancreatic and transplantation fields. Specifically, I am investigating the mechanism of hepatocellular carcinoma recurrence and the development of therapeutic strategies. I am also engaged in research on regenerative medicine, which is cell therapy after liver surgery and liver transplantation.

Basic Information

Major Professional Backgrounds

  • 2009/04/01, 2009/08/31, Hiroshima University Hospital, Clinical Fellow
  • 2012/10/01, 2013/03/31, Hiroshima University Hospital, Clinical Fellow
  • 2013/04/01, 2014/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor (Special Appointment)
  • 2014/04/01, Hiroshima University Hospital, Assistant Professor
  • 2009/09/01, University of Miami, Department of Surgery, Research Associate III
  • 2011/06/01, University of Miami, Department of Surgery, Research Assistant Professor

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Digestive surgery

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  2. 2024, Undergraduate Education, Intensive, Practice of Medicine II
  3. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Gastroenterological and Transplant Surgery
  4. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Gastroenterological and Transplant Surgery
  5. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Gastroenterological and Transplant Surgery
  6. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Gastroenterological and Transplant Surgery

Research Activities

Academic Papers

  1. Comparison of postoperative outcomes in cases achieving sustained virological response with direct-acting antiviral and interferon therapy, J Hepatobiliary Pancreat Sci, 2023
  2. Protocol to evaluate the efficacy and safety of tolvaptan in patients with refractory ascites after liver resection: an open-label, single-arm phase I/II, INTERNATIONAL JOURNAL OF SURGERY PROTOCOLS, 28(1), 1-5, 2024
  3. Efficacy and safety of lenvatinib-transcatheter arterial chemoembolisation sequential therapy followed by surgical resection for intermediate-stage hepatocellular carcinoma beyond Up-to-7 criteria: a study protocol for a multicentre, single-arm, prospective study, BMJ OPEN, 13(10), 202310
  4. Antidonor T-Cell Responses Are Not Attenuated in Elderly Kidney Transplant Recipients, EXPERIMENTAL AND CLINICAL TRANSPLANTATION, 21(5), 422-427, 202305
  5. Effect of Abdominal Aortic Calcification on Recurrence Following Initial Hepatectomy for Colorectal Liver Metastases, ANTICANCER RESEARCH, 44(2), 649-658, 202402
  6. Prognostic impact of pre- and postoperative tumor markers in patients with intrahepatic cholangiocarcinoma, SURGERY TODAY, 54(2), 177-185, 202402
  7. Prospective Exploratory Phase I Clinical Trial Assessing the Safety of Preoperative Marking for Small Liver Tumors, CUREUS JOURNAL OF MEDICAL SCIENCE, 15(12), 20231215
  8. Breaking distance barriers in liver transplantation: Risk factors and outcomes of long-distance liver grafts, SURGERY, 175(2), 513-521, 202402
  9. The aryl hydrocarbon receptor maintains antitumor activity of liver resident natural killer cells after partial hepatectomy in C57BL/6J mice, CANCER MEDICINE, 12(19), 19821-19837, 202310
  10. Preoperative percutaneous or transvascular marking for curative resection of small liver tumours with potential for missing during hepatectomy: a study protocol for an open-label, single-arm phase II study, BMJ OPEN, 13(10), 202310
  11. Impact of a new liver immune status index among patients with hepatocellular carcinoma after initial hepatectomy, ANNALS OF GASTROENTEROLOGICAL SURGERY, 7(6), 987-996, 202311
  12. Serum interleukin-6 level predicts the prognosis for patients with alcohol-related acute-on-chronic liver failure, HEPATOLOGY INTERNATIONAL, 17(5), 1225-1232, 202310
  13. Correlation between serum pro-inflammatory cytokine levels and the prognosis of the patients with acute liver failure, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 38(9), 1637-1646, 202309
  14. Prognosis of repeat hepatectomy for liver transplantable hepatocellular carcinoma recurrence after hepatectomy: a Retrospective Cohort Study with the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO), LANGENBECKS ARCHIVES OF SURGERY, 408(1), 20230816
  15. Effectiveness of Thermal Barrier Bag for Prolonged Vascular Anastomosis in Kidney Transplantation, TRANSPLANTATION PROCEEDINGS, 55(4), 752-755, 202305
  16. Risk Factors for Hepatocellular Carcinoma After Splenectomy in Liver Cirrhotic Patients, AMERICAN SURGEON, 89(4), 769-777, 202304
  17. Evaluation of T-Cell Immune Status of Reduced-Dose Cyclosporine and Everolimus Combination Therapy in Kidney Transplant Patients, TRANSPLANTATION PROCEEDINGS, 55(4), 797-802, 202305
  18. Impact of Abdominal Aortic Calcification on Chronic Kidney Disease After Liver Transplantation: A Retrospective Study, TRANSPLANTATION PROCEEDINGS, 55(4), 956-960, 202305
  19. Genetic Polymorphisms in Follicular Helper T Cell-Related Molecules Predispose Patients to De Novo Donor-Specific Antibody Formation After Kidney Transplantation, TRANSPLANTATION PROCEEDINGS, 55(4), 1048-1054, 202305
  20. Arteriosclerosis Decreases Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Expression on Liver Natural Killer Cells in Living Donor Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 55(4), 906-912, 202305
  21. Impact of Geriatric Nutritional Risk Index After Initial Hepatectomy for Hepatocellular Carcinoma: a Retrospective Cohort Study with the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO), JOURNAL OF GASTROINTESTINAL SURGERY, 27(6), 1152-1158, 202306
  22. A phase I/II study of adoptive immunotherapy using donor liver graft-derived natural killer cells to prevent bloodstream infection after liver transplantation: a study protocol, Transl Med Commun, 7(1), 19, 20220803
  23. Surgery-related disseminated intravascular coagulation predicts postoperative complications, BMC SURGERY, 23(1), 20230411
  24. Effect of abdominal aortic calcification on the prognosis and recurrence of colorectal cancer stages II-III: A retrospective cohort study, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 38(1), 20230121
  25. Protection From Second Warm Ischemic Injury Using a Thermal Barrier Bag in Kidney Transplantation, TRANSPLANTATION DIRECT, 9(3), 202303
  26. Impact of Abdominal Aortic Calcification After Major Hepatobiliary Pancreatic Surgery: A Retrospective Cohort Study, ANTICANCER RESEARCH, 42(12), 5983-5989, 202212
  27. Adoptive immunotherapy with natural killer cells from peripheral blood CD34(+) stem cells to prevent hepatocellular carcinoma recurrence after curative hepatectomy: a study protocol for an open-label, single-arm phase I study, BMJ OPEN, 12(11), 202211
  28. Adoptive immunotherapy overcomes genetic susceptibility to bloodstream infections due to fc-gamma receptor polymorphisms after liver transplantation, AMERICAN JOURNAL OF TRANSPLANTATION, 22(10), 2392-2400, 202210
  29. Acute portal hypertension using portal vein ligation abrogates TRAIL expression of liver-resident NK cells, HEPATOLOGY COMMUNICATIONS, 6(9), 2551-2564, 202209
  30. Polymorphisms in CTLA-4 predict de novo donor specific antibody formation after kidney transplantation, HUMAN IMMUNOLOGY, 83(6), 494-498, 202206
  31. Adoptive transfer of TRAIL-expressing natural killer cells prevents recurrence of hepatocellular carcinoma after partial hepatectomy, TRANSPLANTATION, 82(12), 1712-1719, 20061227
  32. Significant Correlation Between Spleen Volume and Thrombocytopenia in Liver Transplant Patients: A Concept for Predicting Persistent Thrombocytopenia, LIVER TRANSPLANTATION, 15(2), 208-215, 200902
  33. Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice, JOURNAL OF CLINICAL INVESTIGATION, 119(11), 3226-3235, 200911
  34. Clinical-Scale Isolation of Interleukin-2-Stimulated Liver Natural Killer Cells for Treatment of Liver Transplantation With Hepatocellular Carcinoma, CELL TRANSPLANTATION, 21(7), 1397-1406, 2012
  35. Comparative Analysis of T-Cell Depletion Method for Clinical Immunotherapy-Anti-Hepatitis C Effects of Natural Killer Cells Via Interferon-gamma Production, TRANSPLANTATION PROCEEDINGS, 45(5), 2045-2050, 201306
  36. Possibility of Adoptive Immunotherapy With Peripheral Blood-derived CD3(-)CD56(+) and CD3(+)CD56(+) Cells for Inducing Antihepatocellular Carcinoma and Antihepatitis C Virus Activity, JOURNAL OF IMMUNOTHERAPY, 34(2), 137-146, 201103
  37. Impact of Adjuvant Immunotherapy Using Liver Allograft-Derived Lymphocytes on Bacteremia in Living-Donor Liver Transplantation, TRANSPLANTATION, 92(5), 575-580, 201109
  38. Potential Benefit of Mixed Lymphocyte Reaction Assay-based Immune Monitoring After Living Donor Liver Transplantation for Recipients With Autoimmune Hepatitis, TRANSPLANTATION PROCEEDINGS, 46(3), 785-789, 201404
  39. Clinical Efficacy of Simultaneous Splenectomy in Liver Transplant Recipients With Hepatitis C Virus, TRANSPLANTATION PROCEEDINGS, 46(3), 770-773, 201404
  40. Bile CXC Motif Chemokine 10 Levels Correlate With Anti-donor Cytotoxic T Cell Responses After Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 46(3), 790-793, 201404
  41. Risk Factors for Development of New-Onset Diabetes Mellitus and Progressive Impairment of Glucose Metabolism After Living-Donor Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 46(3), 865-869, 201404
  42. Multiple Hepatic Vein Reconstruction Using an All-in-one Sleeve Patch Graft Technique in Living Donor Liver Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 46(3), 982-985, 201404
  43. Impact of alloimmune T cell responses on hepatitis C virus replication in liver transplant recipients, HUMAN IMMUNOLOGY, 75(12), 1259-1267, 201412
  44. Prevention of infection after liver transplantation, 11(1), 61-67, 201402
  45. Treatment of hepatic amyloid light-chain amyloidosis with bortezomib and dexamethasone in a liver transplant patient., Hepatology Research, 45(10), E150-E155, 20150122
  46. Pancreaticoduodenectomy with preservation of gastric tube blood flow after esophagectomy: Report of a case., Int J Surg Case Rep., 201408
  47. Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans., Hepatology, 43(2), 362-372, 20060128
  48. Possible therapeutic effect of lipid supplementation on neurological complications in liver transplant recipients, Transpl Int, 20(7), 632-635, 20070420
  49. Microsurgical hepatic artery reconstruction during living-donor liver transplantation by using head-mounted surgical binocular system, Transpl Int, 20(11), 970-973, 20070720
  50. Prophylaxis against recurrence of HBV hepatitis after living-donor liver transplantation, Hepatogastroenterology, 55(86-87), 1746-1749, 20081224
  51. Using recipient's middle hepatic vein for drainage of the right paramedian sector in right liver graft, Transplantation, 86(11), 1565-1571, 20081217
  52. Successful hepatitis B vaccination in liver transplant recipients with donor-specific hyporesponsiveness, Transpl Int, 22(8), 805-813, 20090606
  53. Efficacy and Feasibility of Salvage Living Donor Liver Transplantation after Initial Liver Resection in Patients with Hepatocellular Carcinoma, Dig Surg, 33(1), 8-14, 2015
  54. An Analysis of Surgical Treatment for the Spontaneous Rupture of Hepatocellular Carcinoma, Dig Surg, 33(1), 43-50, 2015
  55. Treatment of hepatic amyloid light-chain amyloidosis with bortezomib and dexamethasone in a liver transplant patient, HEPATOLOGY RESEARCH, 45(10), E150-E155, 201510
  56. Efficacy and Feasibility of Salvage Living Donor Liver Transplantation after Initial Liver Resection in Patients with Hepatocellular Carcinoma, DIGESTIVE SURGERY, 33(1), 8-14, 2016
  57. An Analysis of Surgical Treatment for the Spontaneous Rupture of Hepatocellular Carcinoma, DIGESTIVE SURGERY, 33(1), 43-50, 2016
  58. Fc-Gamma Receptor Polymorphisms Predispose Patients to Infectious Complications After Liver Transplantation, AMERICAN JOURNAL OF TRANSPLANTATION, 16(2), 625-633, 201602
  59. Intraoperative assessment of tissue oxygen saturation of the remnant stomach by near-infrared spectroscopy in two cases of pancreatectomy following gastrectomy, INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 22, 75-78, 2016
  60. Inflammatory pseudotumor of the liver occurring during the course of hepatitis C virus-related hepatocellular carcinoma treatment: A case report, INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 20, 96-100, 2016
  61. Different sensitivity of rituximab-treatment to B-cells between ABO-incompatible kidney and liver transplantation, HUMAN IMMUNOLOGY, 77(6), 456-463, 201606
  62. Stepwise approach to curative surgery using percutaneous transhepatic cholangiodrainage and portal vein embolization for severe bile duct injury during laparoscopic cholecystectomy: a case report, SURGICAL CASE REPORTS, 2, 20160517
  63. Prediction of long-term survival by using the Glasgow Prognostic Score in patients with hepatocellular carcinoma after liver transplantation, HEPATOLOGY RESEARCH, 46(7), 622-633, 201606
  64. CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment, PLoS One, 11(8), e0161618, 2016
  65. Intrahepatic cholangiocarcinoma coinciding with a liver metastasis from a rectal carcinoma: a case report, Surg Case Rep, 2(1), 94, 20160909
  66. Pseudolymphoma of the liver: a case report and literature review., Surg Case Rep, 1(1), 107, 2015
  67. A case of biliary cystic tumor with repeated hemobilia., Surg Case Rep, 1(1), 34, 2015
  68. CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment, PLOS ONE, 11(8), 20160825
  69. MELD and Child-Pugh Scores Are Related to Immune Status of Intrahepatic Natural Killer Cells in Liver Transplant Candidates, TRANSPLANTATION PROCEEDINGS, 49(1), 98-101, 2017
  70. Evaluation of the risk factors and prognostic factors of hepatectomy for hepatocellular carcinoma in patients aged 80 years or more, JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, 24(1), 58-64, 201701
  71. Efficacy of repeat hepatectomy for recurrence following curative hepatectomy for colorectal liver metastases: A Retrospective Cohort Study of 128 patients, INTERNATIONAL JOURNAL OF SURGERY, 36, 96-103, 201612
  72. Elective laparoscopic deroofing to treat the spontaneous rupture of a large simple liver cyst: a case report, SURGICAL CASE REPORTS, 2, 20161207
  73. Predictive Independent Factors for Extrahepatic Metastasis of Hepatocellular Carcinoma Following Curative Hepatectomy, ANTICANCER RESEARCH, 37(5), 2625-2631, 201705
  74. Biliary-duodenal anastomosis using magnetic compression following massive resection of small intestine due to strangulated ileus after living donor liver transplantation: a case report, SURGICAL CASE REPORTS, 3, 20170525
  75. Impact of Steroids on Natural Killer Cells Against Cytotoxicity and Hepatitis C Virus Replication, TRANSPLANTATION PROCEEDINGS, 49(5), 1160-1164, 201706
  76. Prediction of recurrence following hepatectomy in patients with hepatitis C virus infection-related hepatocellular carcinoma who achieved a sustained virological response., Hepatol Res, 20170323
  77. Perforation of the gallbladder in a patient with acute cytomegalovirus cholecystitis shortly following renal transplantation., Transpl Infect Dis., 20170613
  78. Effect of Fc-g Receptor Polymorphism on Rituximab-Mediated B Cell Depletion in ABO-Incompatible Adult Living Donor Liver Transplantation., Transplant Direct, 3(6), e164, 20170618
  79. Aggressive angiomyxoma of the liver: a case report and literature review, Surg Case Rep, 3(1), 92, 20170824
  80. Acute Graft Rejection and Formation of De Novo Donor-Specific Antibodies Triggered by Low Cyclosporine Levels and Interferon Therapy for Recurrent Hepatitis C Infection After Liver Transplantation: A Case Report, Transplant Proc, 49(7), 1634-1638, 20170825
  81. Aggressive angiomyxoma of the liver: a case report and literature review, SURGICAL CASE REPORTS, 3, 20170823
  82. Acute Graft Rejection and Formation of De Novo Donor-Specific Antibodies Triggered by Low Cyclosporine Levels and Interferon Therapy for Recurrent Hepatitis C Infection After Liver Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 49(7), 1634-1638, 201709
  83. Prediction of recurrence following hepatectomy in patients with hepatitis C virus infection-related hepatocellular carcinoma who achieved a sustained virological response, HEPATOLOGY RESEARCH, 47(11), 1186-1195, 201710
  84. Perforation of the gallbladder in a patient with acute cytomegalovirus cholecystitis shortly following renal transplantation, TRANSPLANT INFECTIOUS DISEASE, 19(5), 201710
  85. Hepatectomy leads to loss of TRAIL-expressing liver NK cells via downregulation of the CXCL9-CXCR3 axis in mice, PLOS ONE, 12(10), 20171031
  86. Utility of hepatobiliary scintigraphy for recurrent reflux cholangitis following choledochojejunostomy: A case report, INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 42, 104-108, 2018
  87. A case report on the successful perioperative management of hepatectomy for hepatocellular carcinoma in a patient with von Willebrand disease, INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 44, 131-134, 2018
  88. A Phased Desensitization Protocol With Rituximab and Bortezomib for Highly Sensitized Kidney Transplant Candidates, TRANSPLANTATION DIRECT, 1(5), 201506
  89. A case of biliary cystic tumor with repeated hemobilia, SURGICAL CASE REPORTS, 1, 2015
  90. Pseudolymphoma of the liver: a case report and literature review, SURGICAL CASE REPORTS, 1, 2015
  91. Hepatic irradiation persistently eliminates liver resident NK cells, PLOS ONE, 13(6), e0198904, 20180613
  92. Prognostic factors in patients with recurrent intrahepatic cholangiocarcinoma after curative resection: A retrospective cohort study, INTERNATIONAL JOURNAL OF SURGERY, 54, 156-162, 201806
  93. Hepatectomy versus stereotactic body radiotherapy for primary early hepatocellular carcinoma: A propensity-matched analysis in a single institution, SURGERY, 164(2), 219-226, 201808
  94. Polymorphisms in TRAIL predict long-term survival and extrahepatic recurrence following initial hepatectomy for hepatocellular carcinoma, J Hepatobiliary Pancreat Sci, 25(8), 370-376, 20180728
  95. Independent risk factors that predict bile leakage after hepatectomy for hepatocellular carcinoma: Cohort study, Int J Surg, 57, 1-7, 20180724
  96. Hybrid Surgery for Portosystemic Encephalopathy in a Patient with Liver Cirrhosis: a case report, Hiroshima Journal of Medical Sciences, 66(1), 11-15, 201703
  97. Independent risk factors that predict bile leakage after hepatectomy for hepatocellular carcinoma: Cohort study, INTERNATIONAL JOURNAL OF SURGERY, 57, 1-7, 201809
  98. Impact of Abdominal Aortic Calcification Among Liver Transplantation Recipients, LIVER TRANSPLANTATION, 25(1), 79-87, 201901
  99. Risk Factors for Refractory Ascites After Living Donor Liver Transplant, TRANSPLANTATION PROCEEDINGS, 51(5), 1516-1519, 201906
  100. Simultaneous Liver-Kidney Transplantation in Patient with a History of Heparin-Induced Thrombocytopenia: A Case Report and Literature Review, AMERICAN JOURNAL OF CASE REPORTS, 20, 980-987, 20190709
  101. Alcohol Use Disorders Identification Test-consumption Predicts the Risk of Excessive Alcohol Consumption After Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 51(6), 1934-1938, 2019
  102. Management of Refractory Ascites for Liver Transplant Candidates: A Novel Cell-free and Concentrated Ascites Reinfusion Therapy, TRANSPLANTATION PROCEEDINGS, 51(8), 2740-2744, 201910
  103. Utility of Doppler Ultrasonography in Liver Transplantation With Celiac Axis Compression Syndrome: A Case Report, TRANSPLANTATION PROCEEDINGS, 51(9), 3103-3106, 201911
  104. Hepatic epithelioid hemangioendothelioma successfully treated with living donor liver transplantation: A case report and literature review, CLINICAL CASE REPORTS, 8(1), 108-115, 20200101
  105. Everolimus enhances TRAIL-mediated anti-tumor activity of liver resident natural killer cells in mice, TRANSPLANT INTERNATIONAL, 33(2), 229-243, 20200201
  106. Successful Treatment of Chronic Myeloid Leukemia With Dasatinib After Kidney Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 52(2), 600-603, 20200301
  107. Essential updates 2018/2019: Liver transplantation, ANNALS OF GASTROENTEROLOGICAL SURGERY, 4(3), 195-207, 20200501
  108. Posttransplant Management of Recipients Undergoing Liver Transplantation for Hepatocellular Carcinoma. Working Group Report From the ILTS Transplant Oncology Consensus Conference, TRANSPLANTATION, 104(6), 1143-1149, 20200601
  109. Treatment outcomes after splenectomy with gastric devascularization or balloon-occluded retrograde transvenous obliteration for gastric varices: a propensity score-weighted analysis from a single institution, JOURNAL OF GASTROENTEROLOGY, 55(9), 877-887, 20200901
  110. Strategies for Deliberate Induction of Immune Tolerance in Liver Transplantation: From Preclinical Models to Clinical Application, FRONTIERS IN IMMUNOLOGY, 11, 20200731
  111. Impact on biliary complications of donor abdominal aortic calcification among living donor liver transplantation: a retrospective study, TRANSPLANT INTERNATIONAL, 33(12), 1745-1753, 20201201
  112. Rapidly Progressive Invasive Urothelial Carcinoma With Flat and Infiltrative Growth Pattern in the Graft Kidney After Living-Related Kidney Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 52(9), 2726-2730, 20201101
  113. Obliteration of a Portosystemic Shunt by Hybrid Interventional Radiology Using a Transmesenteric Approach Under Minilaparotomy After Liver Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 52(9), 2762-2766, 20201101
  114. Analysis of Risk Factors Affecting Incidence of Osteoporosis and Fragility Fractures in Liver Transplant Recipients, ANNALS OF TRANSPLANTATION, 26, 20210205
  115. Loss of antibodies to hepatitis E virus in organ transplant patients with hepatitis E, HEPATOLOGY RESEARCH, 51(5), 538-547, 20210501
  116. Pilot study to determine the safety and feasibility of deceased donor liver natural killer cell infusion to liver transplant recipients with hepatocellular carcinoma, Cancer Immunol Immunother, 20210721
  117. Risk Factors for Hepatocellular Carcinoma After Splenectomy in Liver Cirrhotic Patients, Am Surg, 20210831
  118. Molecular mismatch predicts T cell mediated rejection and de novo donor specific antibody formation after living-donor liver transplantation, Liver Transpl, 20210727
  119. B cell depletion with anti-CD20 mAb exacerbates anti-donor CD4(+) T cell responses in highly sensitized transplant recipients, SCIENTIFIC REPORTS, 11(1), 20210913
  120. Molecular Mismatch Predicts T Cell-Mediated Rejection and De Novo Donor-Specific Antibody Formation After Living Donor Liver Transplantation, LIVER TRANSPLANTATION, 27(11), 1592-1602, 202111
  121. Treatment of multiple huge liver cysts in a hybrid operating room: a case report, SURGICAL CASE REPORTS, 7(1), 20211029
  122. Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study, ANNALS OF GASTROENTEROLOGICAL SURGERY, 6(1), 149-158, 202201
  123. Pilot study to determine the safety and feasibility of deceased donor liver natural killer cell infusion to liver transplant recipients with hepatocellular carcinoma, CANCER IMMUNOLOGY IMMUNOTHERAPY, 71(3), 589-599, 202203

Publications such as books

  1. 2015/10/27, Gene Therapy and Cell Therapy Through the Liver, Novel immunotherapy using liver-derived natural killer cells for preventing hepatocellular carcinoma recurrence in liver transplantation, Springer, 2015, 10, Scholarly Book, Joint work, Ohira M, Nishida S, Tzakis A, Ohdan H, ISBN-10: 4431556656, 185, 35-45

Invited Lecture, Oral Presentation, Poster Presentation

  1. Liver-Resident Natural Killer Cells as Adjuvant Treatment for Hepatocellular Carcinoma Post-Liver Transplantation, Masahiro Ohira, Hideki Ohdan, APASL 2024, 2024/03/27, With Invitation, English
  2. Donor age are correlates with liver resident natural killer cell activity in adoptive immunotherapy using donor liver natural killer cells in liver transplantation, Masahiro Ohira, Yuki Imaoka, Koki Imaoka, Tomoaki Bekki, Ryosuke Nakano, Doskali Marlen, Hiroshi Sakai, Naoki Tanimine, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Yuka Tanaka, Hideki Ohdan, CAST 2023, 2023/08/25, Without Invitation, English
  3. Phase I Study of Adjuvant Immunotherapy Using Donor Liver Natural Killer Cells for Liver Transplant Recipients with Hepatocellular Carcinoma, Masahiro Ohira, Yuki Imaoka, Koki Imaoka, Tomoaki Bekki, Ryosuke Nakano, Hiroshi Sakai, Naoki Tanimine, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Yuka Tanaka, Andreas G Tzakis, Seigo Nishida, Hideki Ohdan, American Transplant Congress 2023, 2023/06/03, Without Invitation, English
  4. Phase I study of adjuvant immunotherapy using donor liver derived NK cells for preventing HCC recurrence after liver transplantation, Masahiro Ohira, Yuki Imaoka, Koki Sato, Koki Imaoka, Naoki Tanimine, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Yuka Tanaka, Andreas G Tzakis, Seigo Nishida, Hideki Ohdan, ILTS 2022, 2022/05/04, Without Invitation, English
  5. Clinical efficacy of adjuvant immunotherapy for liver transplant recipients with exceeding Japan criteria of hepatocellular carcinoma using donor liver derived natural killer cells, Masahiro Ohira, Yuki Imaoka, Koki Sato, Koki Imaoka, Naoki Tanimine, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Yuka Tanaka, Andreas G Tzakis, Seigo Nishida, Hideki Ohdan, American Transplant Congress 2022, 2022/06/04, Without Invitation, English
  6. International Liver Transplantation Society (ILTS) Congress, Naofumi Tsukiyama, Yuka Tanaka, Akhmet Seidakhmetov, Yuki Imaoka, Ryosuke Nakano, Naoki Tanimine, Doskali Marlen, Masahiro Ohira, Hiroyuki Tahara, Kentaro Ide, Hideki Ohdan, American Transplant Congress 2022, 2022/06/04, Without Invitation, English
  7. Analysis of intracellular signaling mediated by the aryl hydrocarbon receptor (AhR) in liver-resident NK cells, Koki Sato, Koki Sato,Masahiro Ohira, Yuki Imaoka, Koki Imaoka, Ryosuke Nakano, Naoki Tanimine, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Yuka Tanaka, Hideki Ohdan, International Liver Transplantation Society (ILTS) Congress, 2022/05/04, Without Invitation, English
  8. Polymorphisms in CTLA-4 predict de novo donor specific antibody formation after kidney transplantation, Kosuke Ono, Kosuke Ono, Kentaro Ide, Hiroaki Yamane, Shuji Akimoto, Naoki Tanimine, Hiroyuki Tahara, Masahiro Ohira, Yuka Tanaka, Hideki Ohdan, American Transplant Congress 2022, 2022/06/04, Without Invitation, English
  9. Safety and efficacy of novel cell-free and concentrated ascites reinfusion therapy (KM-CART) for refractory ascites in liver transplant candidates, Sato K, Ohira M,Imaoka Y,Hashimoto S,Tahara H,Ide K,Kobayashi T,Tanaka Y,Ohdan H, 19th Congress of the Euuropean Society for Organ Transplantation, 2019/09/15, Without Invitation, English
  10. Class II HLA Eplet mismatch is a risk factor for de novo Donor-Specific antibody development in kidney transplantation recipient., Yamane H, Tanaka Y,Ono K,Ohira M,Tahara H,Ide K,Ohdan H, 19th Congress of the Euuropean Society for Organ Transplantation, 2019/09/15, Without Invitation, English
  11. INVESTIGATION OF FACTORS AFFECTING PERIOPERATIVE NUTRITIONAL STATUS IN KIDNEY TRANSPLANTATION, Akimoto S, Tahara H, Akhmet Seidakhmetov,Yamane H,Sato K,Imaoka Y,Honmyo N,Nakashima I,Taguchi K,Tanaka A,Jamilya Saparbay,Doskali Marlen, Hashimoto S,Ohira M,Ide K,Tanaka Y,Ohdan H, 19th Congress of the Euuropean Society for Organ Transplantation, 2019/09/15, Without Invitation, English
  12. Surgery-related DIC Predicts the Severity of Complication after Major Hepatobiliary Pancreatic Surgery, Seidakhmetov Akhmet, Imaoka Y,Ohira M,Sato K,Uemura K,Kuroda S,Tahara H,Ide K, Kobayashi T,Ohdan H, A-PHPBA2019, 2019/09/04, Without Invitation, English
  13. Surgery-related DIC Predicts the Severity of Complication after Major Hepatobiliary Pancreatic Surgery, Seidakhmetov Akhmet, Imaoka Y,Ohira M,Sato K,Uemura K,Kuroda S,Tahara H,Ide K,Kobayashi T,Ohdan H, The Liver Week 2019, 2019/06/20, Without Invitation, English
  14. Impact of Donor Abdominal Aortic Calcification On Bile Duct Complication of Recipients After Livinf Donor Liver Transplantation: A Retrospective Study, imaoka Y, Ohira M,Sato K,Hashimoto S,Tahara H,Ide K,Kobayashi T,Tanaka Y,Ohdan H, 2019 American Transplant Congress, 2019/06/01, Without Invitation, English
  15. Novel cell-free and concentrated ascites reinfusion therapy (KM-CART) for management of refractory ascites in liver transplant candidates, Sato K, Ohira M,Imaoka Y,Hashimoto S,Tahara H,Ide K,Kobayashi T,Tanaka Y,Ohdan H, American Transplant Congress 2019, 2019/06/01, Without Invitation, English
  16. Adjuvant Immunotherapeutic Approach For Liver Transplant Recipients With Hepatocellular Carcinoma Using Donor Liver Derived Natural Killer Cells, Ohira M, Imaoka Y,Sato K,Tahara H,Ide K,Kobayashi T,Tanaka Y,Ohdan H, 2019 American Transplant Congress, 2019/06/01, Without Invitation, English
  17. B-cell depletion with rituximab exacerbates anti-donor CD4+ T-Cell responses in patients with donor-specific anti-human leukocyte antigen antibodies, Kentaro Ide, Yuka Tanaka, Hiroyuki Tahara, Masahiro Ohira, Seiichi Shimizu, Asuka Tanaka, Hideki Ohdan, 27th International Congress of the Transplantation Society, 2018/06/30, Without Invitation, English
  18. Predictive factors analysis of osteoporosis and fragility fractures after liver transplantation, Shuji Akimoto, Hiroyuki Tahara, Das Lalit Kumar, Yuki Imaoka, Naruhiko Honmyo, Ikki Nakashima, Kazuhiro Taguchi, Asuka Tanaka, Ryosuke Nakano, Jamilya Saparbay, Nobuki Ishida, Senichiro Yanagawa, Hiroshi Sakai, Seiichi Shimizu, Masahiro Ohira, Kentaro Ide, Tsuyoshi Kobayashi, Yuka Tanaka, Hideki Ohdan, 27th International Congress of The Transplantation Society, 2018/06/30, Without Invitation, English
  19. Impact of Aortic Abdominal Calcification among Living Donor Liver Transplant Recipients; A retrospective study, Yuki Imaoka, Masahiro Ohira, Takuya Yano, Ryosuke Nakano, Naoki Tanimine, Seiichi Shimizu, Shintaro Kuroda, Hiroyuki Tahara, Tsuyoshi Kobayashi, Yuka Tanaka, Hideki Ohdan, 2018 American Transplant Congress, 2018/06/02, Without Invitation, English
  20. B-cell depletion with rituximab exacerbates anti-donor CD4+ T-Cell responses in patients with donor-specific anti-human leukocyte antigen antibodies, Tanaka A, Kentaro Ide, Yuka Tanaka, Masahiro Ohira, Hiroyuki Tahara, Seiichi Shimizu, Hideki Ohdan., 2018 American Transplant Congress, 2018/06/02, Without Invitation, English
  21. Impact of Polymorphisms in TRAIL among hepatectomy for primary hepatocellular carcinoma, Yuki Imaoka, Masahiro Ohira, Hideki Ohdan, The 17th meeting of the Society for Natural Immunity, 2018/05/28, Without Invitation, English
  22. Novel immunotherapy using liver natural killer cells for preventing recurrence of hepatocellular carcinoma in liver transplantation, Masahiro Ohira, Ryosuke Nakano, Yuki Imaoka, Yuka Tanaka, Seiichi Shimizu, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Andreas G Tzakis, Seigo Nishida, Hideki Ohdan, The 17th meeting of the Society for Natural Immunity, 2018/05/28, Without Invitation, English
  23. Impact of multiplicity of functional KIR-HLA compound genotypes in liver transplantation, Yano T., Tanimine N, Kurita E, Nakano R, Shimizu S, Ohira M, Ishiyama K, Tanaka Y, Ohdan H, 6th A-PHPBA/29th JSHBPS, 2017/06/07, Without Invitation, English
  24. Prognosis after liver resection for intermediate stage hepatocellular carcinoma, Okimoto.S, Kobayashi T, Kudora S, Ishiyama K, Ide K, Ohira M, Tahara H, Shimizu S, Ohdan H, 6th A-PHPBA/29th JSHBPS, 2017/06/07, Without Invitation, English
  25. Anatomical hepatectomy with the midline incision for right-sided liver tumors, Kobayashi T, Sho Okimoto, Shintaro Kuroda,Michinori Hamaoka,Seiichi Shimizu,Hiroyuki Tahara,Masahiro Ohira,Kentaro Ide,Kohei Ishiyama,Hideki Ohdan, 6th A-PHPBA/29th JSHBPS, 2017/06/07, Without Invitation, English
  26. Fcg receptor polymorphism influences the effect of rituximab on B-cell depletion in ABO-incompatible adult living donor liver transplantation, Sakai H, Hiroshi Sakai, Yuka Tanaka, Seiichi Shimizu, Kentaro Ide, Kohei Ishiyama, Takashi Onoe, Masahiro Ohira, Hiroyuki Tahara, Tsuyoshi Kobayashi and Hideki Ohdan, 6th A-PHPBA/29th JSHBPS, 2017/06/07, Without Invitation, English
  27. Approaches to improve pancreas transplant outcome at Hiroshima University, Kohei Ishiyama, Hiroyuki Tahara, Masahiro Ohira, Kentaro Ide, Tsuyoshi Kobayashi, Yuka Tanaka, Hideki Ohdan, 6th A-PHPBA/29th JSHBPS, 2017/06/07, Without Invitation, English
  28. The management for portal vein thrombosis / stenosis in liver transplantation, Seiichi Shimizu, Takashi Onoe, Hirotaka Tashiro, Kohei Ishiyama, Kentaro Ide, Masahiro Ohira, Hiroyuki Tahara, Tsuyoshi Kobayashi, Shintaro Kuroda, and Hideki Ohdan, 6th A-PHPBA/29th JSHBPS, 2017/06/07, Without Invitation, English
  29. Evaluation of Immunological States of Patients with Cytomegalovirus Infection After Kidney Transplantation, Tanaka A, Kentaro Ide, Yuka Tanaka, Kohei Ishiyama, Masahiro Ohira, Hiroyuki Tahara, Seiichi Shimizu, Das Lalit Kumar and Hideki Ohdan, American Transplant Congress 2017, 2017/04/29, Without Invitation, English
  30. Current status of desensitization protocol for highly HLA-sensitized kidney transplant candidates, 2017/02/15, Without Invitation, English
  31. Corticosteroids dampen Natural Killer cell function including cytotoxicity and anti-HCV effect, Masahiro Ohira, Ryuichi Hotta, Takuya Yano, Ryosuke Nakano, Andreas Tzakis, Seigo Nishida, Hideki Ohdan, Asian Transplantation Week 2016, 2016/10/29, Without Invitation, English
  32. Cotransplantation of preactivated mesenchymal stem cells inhibits liver natural killer cell–induced islet graft injury during instant blood-mediated inflammatory reaction after syngeneic intraportal islet transplantation, Ishida N Ohdan H, Ishiyama K, Saeki Y, Tanaka Y, Tahara H, Verma S, Saparbay D, Sasaki Y, Onoe T, Ohira M, Yano T, Yanagawa S, Taguchi K, Piao J, Tanaka A, Ide K, Shimizu S, Das L K, Nakano R., 26th International Congress of the Transplantation Society, 2016/08/18, Without Invitation, English
  33. Negative influence of liver irradiation on liver resident NK cells., Nakano R Ohira M, Yano T, Ohdan H., 26th International Congress of the Transplantation Society, 2016/08/18, Without Invitation, English
  34. Different sensitivity of rituximab-treatment to B-cells between ABO-incompatible kidney and liver transplantation., Tanaka A Morimoto H, IdeK, Tanaka Y, Ishiyama K, Ohira M, Tahara H, Shimizu S, Saeki Y, Sakai H, Tano T, Ishida N, Yanagawa S, Tagushi K, Nakano R, Ohdan H., 26th International Congress of the Transplantation Society, 2016/08/18, Without Invitation, English
  35. Reduction in CXCL9–CXCR3 signals diminishes TRAIL-expressing liver NK cells in partially hepatectomized mice under depressed immune status., Yano T Ohira M, Nakano R, Ohdan H., 26th International Congress of the Transplantation Society, 2016/08/18, Without Invitation, English
  36. Immunotherapy using donor liver NK cells for preventing severe infection after liver transplantation, 2016/07/13, Without Invitation, Japanese
  37. The Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) predicts the risk of excessive alcohol consumption in patients, Yano T. Ohira M, Sakamoto R, Narisada A, Tahara H, Ide K, Ishiyama K, Ohdan H., Transplantation Science Symposium Asian Regional Meetingb 2016, 2016/04/08, Without Invitation, Japanese
  38. A phased desensitization protocol with rituximab and bortezomib for highly HLA-sensitized kidney transplant candidates., Ide K Tanaka Y, Sasaki Y, Tahara H, Ohira M, Ishiyama K, Tashiro H, Ohdan H., CAST 2015, 2015/08/23, Without Invitation, English
  39. A case report of successful ABO incompatible renal transplantation from a well-treated HCV positive donor with SVR to HCV negative recipient without any viral transplantation., Verma S Ide K, Shimizu S, Ishiyama K, Ohira M, Tahara H, Tanaka Y, Das KL, Tashiro H, Ohdan H., CAST 2015, 2015/08/23, Without Invitation, English
  40. ERAS using early enteral nutrition prevents systemic inflammatory response syndrome and infection after living donor liver transplantation., Onoe T, Tanaka Y, Ishiyama K, Ide K, Ohira M, Tahara H, Kobayashi T, Kuroda S, Tashiro H, Ohdan H, A-PHPBA 2015, 2015/03/17, Without Invitation, English

Awards

  1. 2006, 2006 World Transplant Congress Young Investigator Award, World Transplant Congress
  2. 2009, 2009 American Transplant Congress Young Investigator Award, American Transplant Congress
  3. 2011, 2011 Annual Scientific Exchange Young Innovator Award, ASTS
  4. 2014, 2014 ILTS Young Investigator Award, ILTS, Novel adjuvant immunotherapy using liver natural killer cells for preventing recurrence of hepatocellular carcinoma in liver transplantation.
  5. 2016/10/29, 2016 Asian Transplant Week, Best Abstract Award (Silver), Asian Transplant Society

Social Activities

History as Peer Reviews of Academic Papers

  1. 2021, Frontiers in Immunology, Others, 1
  2. 2021, Annals of Transplantation, Others, 1
  3. 2013, Hepatology Research, Others, Reviewer, 2
  4. 2013, Transplant International, Others, Reviewer, 1
  5. 2014, Transplant International, Others, Reviewer, 1
  6. 2014, Hepatology Research, Others, Reviewer, 1
  7. 2014, Surgery Today, Others, Reviewer, 1
  8. 2015, Hepatology Research, Others, Reviewer, 2
  9. 2015, Transplant International, Others, Reviewer, 1
  10. 2016, Hepatology Research, Others, Reviewer, 1
  11. 2016, Asia-Pacific Journal of Clinical Oncology, Others, Reviewer, 1
  12. 2016, World Journal of Gastroenterology, Others, Reviewer, 3
  13. 2016, Clinical Journal of Gastroenterology, Others, Reviewer, 1
  14. 2016, World Journal of Radiology, Others, Reviewer, 1
  15. 2017, World Journal of Gastroenterology, Others, Reviewer, 10
  16. 2017, Surgery Today, Others, Reviewer, 1
  17. 2017, World Journal of Hepatology, Others, Reviewer, 1
  18. 2017, Transplant International, Others, Reviewer, 1
  19. 2017, Clinical Transplantation, Others, Reviewer, 1