Kei Tobiume

Last Updated :2025/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Associate Professor
E-mail
tobi5651hiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Dental Science, Tokyo Medical and Dental University

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Functional basic dentistry

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 2Term, General Health and Oral Sciences I
  2. 2025, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  3. 2025, Undergraduate Education, 4Term, Life Science
  4. 2025, Undergraduate Education, 4Term, Immunology
  5. 2025, Undergraduate Education, First Semester, Basic Technique for Microbiology and Immunology
  6. 2025, Undergraduate Education, 2Term, Topics in Dental Research II
  7. 2025, Undergraduate Education, First Semester, Dental Research Practices I
  8. 2025, Undergraduate Education, Second Semester, Dental Research Practices II
  9. 2025, Undergraduate Education, 2Term, Basic and Clinical Integrated Theory
  10. 2025, Undergraduate Education, 1Term, Immunology
  11. 2025, Undergraduate Education, 1Term, Immunology
  12. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Mucosal Immunology
  13. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Mucosal Immunology
  14. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Mucosal Immunology
  15. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Mucosal Immunology

Research Activities

Academic Papers

  1. Overexpression of receptor for hyaluronan-mediated motility (RHAMM) in MC3T3-E1 cells induces proliferation and differentiation through phosphorylation of ERK1/2, JOURNAL OF BONE AND MINERAL METABOLISM, 30(3), 293-303, 201205
    Link to Paper Search Results by DOI
  2. Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous cell carcinoma, CANCER LETTERS, 329(2), 243-252, 20130228
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  3. Interleukin-8 and CXCL10 expression in oral keratinocytes and fibroblasts via Toll-like receptors, MICROBIOLOGY AND IMMUNOLOGY, 57(3), 198-206, 201303
    Link to Paper Search Results by DOI
  4. AKT Primes Snail-Induced EMT Concomitantly With the Collective Migration of Squamous Cell Carcinoma Cells, JOURNAL OF CELLULAR BIOCHEMISTRY, 114(9), 2039-2049, 201309
    Link to Paper Search Results by DOI
  5. Snail-induced down-regulation of Delta Np63 alpha acquires invasive phenotype of human squamous cell carcinoma, Cancer Research, 67(19), 9207-9213, 20071001
  6. Suppression of AP-1 activity by cycloprodigiosin hydrochloride., Biol Pharm Bull, 30(9), 1792-1795, 20070901
  7. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1, J Biol Chem, 282(10), 7522-7533, 20070301
  8. Involvement of Bcl-2 family proteins in p53-induced apoptosis., J Nippon Med Sch, 72(4), 192-193, 20050801
  9. A role for Id in the regulation of TGF-beta-induced epithelial-mesenchymal transdifferentiation., Cell Death Differ, 11(10), 1092-1101, 20041001
  10. Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation., EMBO Rep, 5(2), 161-166, 20040201
  11. Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice, Antioxid Redox Signal, 4(3), 415-425, 20020601
  12. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats., Genes Dev, 16(11), 1345-1355, 20020601
  13. Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer., J Cell Physiol, 191(1), 95-104, 20020401
  14. Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress., EMBO J, 20(21), 6028-6036, 20011101
  15. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis., EMBO Rep, 2(3), 222-228, 20010301
  16. Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase., J Cell Sci, 114(6), 1221-1227, 20010301
  17. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1., EMBO J, 17(9), 2596-2606, 19980501
  18. Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1., iochem Biophys Res Commun, 239(3), 905-910, 19971001
  19. RHAMM/ERK interaction induces proliferative activities of cementifying fibroma cells through a mechanism based on the CD44-EGFR.Hatano H, Shigeishi H, Kudo Y, Higashikawa K, Tobiume K, Takata T, Kamata N.Lab Invest. 2011 Mar;91(3):379-91., Lab Invest, 20110301
  20. Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification.Kawauchi K, Araki K, Tobiume K, Tanaka N.Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3431-6., Proc Natl Acad Sci U S A, 20090301
  21. Activated p53 induces NF-kappaB DNA binding but suppresses its transcriptional activation.Kawauchi K, Araki K, Tobiume K, Tanaka N.Biochem Biophys Res Commun. 2008 Jul 18;372(1):137-41., Biochem Biophys Res Commun, 20080701
  22. p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.Kawauchi K, Araki K, Tobiume K, Tanaka N.Nat Cell Biol. 2008 May;10(5):611-8, Nat Cell Biol, 20080501
  23. Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, Oren M, Tanaka N.Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4838-43., Proc Natl Acad Sci U S A, 20080301
  24. Gene expression profiling to identify genes associated with high-invasiveness in human squamous cell carcinoma with epithelial-to-mesenchymal transition.Higashikawa K, Yoneda S, Taki M, Shigeishi H, Ono S, Tobiume K, Kamata N.Cancer Lett. 2008 Jun 18;264(2):256-64, Cancer Lett, 20080601
  25. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(10), 7522-7531, 20070309
    Link to Paper Search Results by DOI
  26. Suppression of AP-1 activity by cycloprodigiosin hydrochloride, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 30(9), 1792-1795, 200709
    Link to Paper Search Results by DOI
  27. Cycloprodigiosin hydrochloride activates the Ras-PI3K-Akt pathway and suppresses protein synthesis inhibition-induced apoptosis in PC12 cells, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 72(6), 1564-1570, 200806
    Link to Paper Search Results by DOI
  28. ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis, EMBO JOURNAL, 28(7), 843-853, 20090408
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  29. Delta Np63 alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma, INTERNATIONAL JOURNAL OF CANCER, 124(12), 2837-2844, 20090615
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  30. PGE(2) targets squamous cell carcinoma cell with the activated epidermal growth factor receptor family for survival against 5-fluorouracil through NR4A2 induction, CANCER LETTERS, 307(2), 227-236, 20110828
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  31. Blocking of sodium and potassium ion-dependent adenosine triphosphatase-alpha 1 with ouabain and vanadate suppresses cell-cell fusion during RANKL-mediated osteoclastogenesis, EUROPEAN JOURNAL OF PHARMACOLOGY, 670(2-3), 409-418, 20111130
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  32. Autocrine galectin-1 promotes collective cell migration of squamous cell carcinoma cells through up-regulation of distinct integrins, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441(4), 904-910, 20131129
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  33. TMEM16E (GDD1) Exhibits Protein Instability and Distinct Characteristics in Chloride Channel/Pore Forming Ability, JOURNAL OF CELLULAR PHYSIOLOGY, 229(2), 181-190, 201402
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  34. Expression and Function of RIG-I in Oral Keratinocytes and Fibroblasts, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 34(5), 1556-1565, 2014
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  35. p53 regulates cytoskeleton remodeling to suppress tumor progression, CELLULAR AND MOLECULAR LIFE SCIENCES, 72(21), 4077-4094, 201511
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  36. CD44(high)/ALDH1(high) head and neck squamous cell carcinoma cells exhibit mesenchymal characteristics and GSK3-dependent cancer stem cell properties, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 45(3), 180-188, 201603
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  37. Snail-induced CD44(high) cells in HNSCC with high ABC transporter capacity exhibit potent resistance to cisplatin and docetaxel, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 9(8), 7908-7918, 2016
  38. Candida albicans beta-Glucan-Containing Particles Increase HO-1 Expression in Oral Keratinocytes via a Reactive Oxygen Species/p38 Mitogen-Activated Protein Kinase/Nrf2 Pathway, INFECTION AND IMMUNITY, 86(4), 201804
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  39. D-Serine Induced by Ocular Hypertension is Associated with Retinal Cell Death, Current Trends in Ophthalmology, 1(1), 23-29
  40. Effect of Ocular Hypertension on D--Aspartic Acid-Containing Proteins in the Retinas of Rats, JOURNAL OF OPHTHALMOLOGY, 2019
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  41. D-Alanine Is Reduced by Ocular Hypertension in the Rat Retina, CURRENT EYE RESEARCH, 45(4), 490-495, 20200402
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  42. Dysferlin-deficient myotubes show tethering of different membrane compartments characterized by TMEM16E and DHPR alpha, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 529(3), 720-725, 20200827
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  43. The squamous cell carcinoma cell line OM-1 retains both p75-dependent stratified epithelial progenitor potential and cancer stem cell properties, BIOCHEMISTRY AND BIOPHYSICS REPORTS, 26, 202107
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