TAKUYA SUZUKI

Last Updated :2024/06/06

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
Web Site
E-mail
takuyahiroshima-u.ac.jp
Other Contact Details
1-4-4, Kagamiyama, Higashi-Hiroshima, Japan
TEL : (+81)82-424-7984 FAX : (+81)82-424-7916
Self-introduction
Roles of food factors and nutrients in intestinal function and health.

Basic Information

Major Professional Backgrounds

  • 1998/04/01, 2000/12/03, Meiji Dairies Corporation, Researcher
  • 2000/04/01, 2002/03/31, Meiji Dairies Corporation, Senior Staff
  • 2005/04/01, 2008/06/30, Japan Society for the Promotion of Science, Special Postdoctoral Researcher
  • 2008/07/01, 2009/12/31, Hokkaido University, *
  • 2010/01/01, 2013/03/31, Hiroshima University, Graduate School of Biosphere Science, Associate Professor
  • 2013/04/01, 2016/03/31, Hiroshima University, Graduate School of Biosphere Science, Associate Professor
  • 2016/04/01, 2019/03/31, Hiroshima University, Graduate School of Biosphere Science, Professor
  • 2019/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Professor

Educational Backgrounds

  • HOKKAIDO UNIVERSITY, Japan, 2002/04, 2005/03
  • HOKKAIDO UNIVERSITY, Japan, 1996/04, 1998/03
  • HOKKAIDO UNIVERSITY, Japan, 1992/04, 1996/03

Academic Degrees

  • Doctor of Agriculture, HOKKAIDO UNIVERSITY
  • Master of Agriculture, HOKKAIDO UNIVERSITY

Educational Activity

  • [Bachelor Degree Program] School of Applied Biological Science : Department of Applied Biological Science : Food Science Program
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science

In Charge of Primary Major Programs

  • Food Science Program

Research Fields

  • Agricultural sciences;Agricultural chemistry;Food science

Research Keywords

  • Functional foods
  • Gastrointestine
  • polyphenol
  • Dietary fiber
  • Zinc
  • Probiotics

Affiliated Academic Societies

  • Japanese association for dietary fiber research
  • Japan Society of Nutrition and Food Science
  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • Japanese Biochemial Society
  • Japanese Association for Food Immunology

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 1Term, Introduction to Applied Biological Sciences toward SDGs
  2. 2024, Liberal Arts Education Program1, 3Term, Food safety and health science
  3. 2024, Graduate Education (Master's Program) , Intensive, Academic approach to SDGs - B
  4. 2024, Undergraduate Education, 1Term, Introduction to Applied Biological Sciences
  5. 2024, Undergraduate Education, Intensive, Laboratory Work in General Physics
  6. 2024, Undergraduate Education, 1Term, Introduction to Physiology
  7. 2024, Undergraduate Education, 4Term, Introduction to Molecular Biochemistry
  8. 2024, Undergraduate Education, Second Semester, Graduation Thesis I
  9. 2024, Undergraduate Education, First Semester, Graduation Thesis II
  10. 2024, Undergraduate Education, Second Semester, Graduation Thesis III
  11. 2024, Undergraduate Education, 4Term, Food Biochemistry
  12. 2024, Undergraduate Education, Intensive, Laboratory Work in Food Chemistry
  13. 2024, Undergraduate Education, 2Term, Reading of Foreign Literature in Food Science
  14. 2024, Undergraduate Education, 1Term, Food Function (Functional Food Science)
  15. 2024, Undergraduate Education, Intensive, Training for Animal Food Processing
  16. 2024, Undergraduate Education, Intensive, Overseas Exercise of Applied Biological Science I
  17. 2024, Undergraduate Education, Intensive, Overseas Exercise of Applied Biological Science II
  18. 2024, Undergraduate Education, First Semester, Graduate Thesis I
  19. 2024, Undergraduate Education, Second Semester, Graduate Thesis II
  20. 2024, Undergraduate Education, First Semester, Graduate Thesis III
  21. 2024, Undergraduate Education, Second Semester, Graduate Thesis IV
  22. 2024, Undergraduate Education, Intensive, (AIMS) Modern Food Science
  23. 2024, Undergraduate Education, 3Term, Modern Food Science
  24. 2024, Undergraduate Education, Intensive, Independent study of International issues and challenge
  25. 2024, Undergraduate Education, Intensive, International Applied Biological Sciences I
  26. 2024, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  27. 2024, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  28. 2024, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  29. 2024, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  30. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science
  31. 2024, Graduate Education (Master's Program) , 1Term, Nutrition and Food Functions I

Research Activities

Academic Papers

  1. Sophisticated expression responses of ZNT1 and MT in response to changes in the expression of ZIPs, SCIENTIFIC REPORTS, 12(1), 20220505
  2. Regulation of the intestinal barrier by nutrients: The role of tight junctions, ANIMAL SCIENCE JOURNAL, 91(1), 2020
  3. Brazilian propolis extract reduces intestinal barrier defects and inflammation in a colitic mouse model, NUTRITION RESEARCH, 69, 30-41, 201909
  4. Supplemental feeding of phospholipid-enriched alkyl phospholipid from krill relieves spontaneous atopic dermatitis and strengthens skin intercellular lipid barriers in NC/Nga mice, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 83(4), 717-727, 20190403
  5. Repeated exposure to water immersion stress reduces the Muc2 gene level in the rat colon via two distinct mechanisms, BRAIN BEHAVIOR AND IMMUNITY, 26(7), 1061-1065, 2012
  6. Chicken Collagen Hydrolysate-derived Peptides Inhibit Tumor Necrosis Factor-alpha-induced Inflammatory Response in Endothelial Cells, FOOD SCIENCE AND TECHNOLOGY RESEARCH, 18(5), 667-671, 2012
  7. Interleukin-6 (IL-6) Regulates Claudin-2 Expression and Tight Junction Permeability in Intestinal Epithelium, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(36), 31263-31271, 20110909
  8. 5,7-Dimethoxyflavone enhances barrier function by increasing occludin and reducing claudin-2 in human intestinal Caco-2 cells, JOURNAL OF FUNCTIONAL FOODS, 85, 202110
  9. Curcumin increases heat shock protein 70 expression via different signaling pathways in intestinal epithelial cells, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 707, 20210815
  10. Propionate and Dietary Fermentable Fibers Upregulate Intestinal Heat Shock protein70 in Intestinal Caco-2 Cells and Mouse Colon, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69(30), 8460-8470, 20210804
  11. Fermented date residue extract mix containing gamma-aminobutyric acid augments the immune function of mouse splenocytes, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 85(7), 1753-1758, 20210624
  12. Citrus limon Peel Powder Reduces Intestinal Barrier Defects and Inflammation in a Colitic Murine Experimental Model, FOODS, 10(2), 202102
  13. Fermentable fibers upregulate suppressor of cytokine signaling1 in the colon of mice and intestinal Caco-2 cells through butyrate production, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 84(11), 2337-2346, 20201101
  14. Lactobacillus pentosus strain S-PT84 improves steatohepatitis by maintaining gut permeability, JOURNAL OF ENDOCRINOLOGY, 247(2), 169-181, 202011
  15. Development of a Multifunction Set Yogurt Using Rubus suavissimus S. Lee (Chinese Sweet Tea) Extract, FOODS, 9(9), 202009
  16. Exopolysaccharides from Leuconostoc mesenteroides NTM048 Attenuate the Disease Symptoms of Murine Model of Psoriasis., 24(1), 29-38, 2020
  17. The biological activity of fermented milk produced by Lactobacillus casei ATCC 393 during cold storage, INTERNATIONAL DAIRY JOURNAL, 91, 1-8, 201904
  18. Naringenin promotes recovery from colonic damage through suppression of epithelial tumor necrosis factor-alpha production and induction of M2-type macrophages in colitic mice, NUTRITION RESEARCH, 64, 82-92, 201904
  19. Exopolysaccharides from Leuconostoc mesenteroides attenuate chronic kidney disease in mice by protecting the intestinal barrier, JOURNAL OF FUNCTIONAL FOODS, 52, 276-283, 201901
  20. Establishment of a method for determining the origin of glutamic acid in processed food based on carbon and nitrogen stable isotope ratios, HELIYON, 5(1), 201901
  21. Bioactive factors secreted by Bifidobacterium breve B-3 enhance barrier function in human intestinal Caco-2 cells, BENEFICIAL MICROBES, 10(1), 89-100, 2019
  22. Analysis of hypoxia-associated dendritic cells in colitic mice and effects of probiotics on IL-10 production in inflammatory dendritic-cells under hypoxia, BENEFICIAL MICROBES, 10(7), 801-810, 2019
  23. Resveratrol Ameliorates Intestinal Barrier Defects and Inflammation in Colitic Mice and Intestinal Cells, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66(48), 12666-12674, 20181205
  24. Resveratrol enhances intestinal barrier function by ameliorating barrier disruption in Caco-2 cell monolayers, JOURNAL OF FUNCTIONAL FOODS, 51, 39-46, 201812
  25. Citrus kawachiensis Peel Powder Reduces Intestinal Barrier Defects and Inflammation in Colitic Mice, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66(42), 10991-10999, 20181024
  26. Distinguishing glutamic acid in foodstuffs and monosodium glutamate used as seasoning by stable carbon and nitrogen isotope ratios, HELIYON, 4(9), 201809
  27. Dietary Fermentable Fibers Attenuate Chronic Kidney Disease in Mice by Protecting the Intestinal Barrier, JOURNAL OF NUTRITION, 148(4), 552-561, 201804
  28. Short-Chain Fatty Acids Suppress Inflammatory Reactions in Caco-2 Cells and Mouse Colons, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66(1), 108-117, 20180110
  29. Supplemental psyllium fibre regulates the intestinal barrier and inflammation in normal and colitic mice, BRITISH JOURNAL OF NUTRITION, 118(9), 661-672, 20171114
  30. Guar gum fiber increases suppressor of cytokine signaling-1 expression via toll-like receptor 2 and dectin-1 pathways, regulating inflammatory response in small intestinal epithelial cells, MOLECULAR NUTRITION & FOOD RESEARCH, 61(10), 201710
  31. Regulation of the intestinal tight junction by natural polyphenols: a mechanistic perspective., Crit Rev Food Sci Nutr, 2017
  32. Dietary psyllium fiber increases intestinal heat shock protein 25 expression in mice, NUTRITION RESEARCH, 39, 25-33, 2017
  33. A novel whey tetrapeptide IPAV reduces interleukin-8 production induced by TNF-alpha in human intestinal Caco-2 cells, JOURNAL OF FUNCTIONAL FOODS, 35, 376-383, 2017
  34. Supplemental feeding of a gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, alleviates spontaneous atopic dermatitis and modulates intestinal microbiota in NC/nga mice, INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 68(8), 941-951, 2017
  35. Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective, CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 57(18), 3830-3839, 2017
  36. ★, Cellular zinc is required for intestinal epithelial barrier maintenance via the regulation of claudin-3 and occludin expression., Am J Physiol Gastrointest Liver Physiol., 311(1), G105-G116, 20160701
  37. High-fat Diet-induced Intestinal Hyperpermeability is Associated with Increased Bile Acids in the Large Intestine of Mice, JOURNAL OF FOOD SCIENCE, 81(1), H216-H222, 2016
  38. ★, Dietary Fermentable Fiber Reduces Intestinal Barrier Defects and Inflammation in Colitic Mice, JOURNAL OF NUTRITION, 146(10), 1970-1979, 2016
  39. Supplemental epilactose prevents metabolic disorders through uncoupling protein-1 induction in the skeletal muscle of mice fed high-fat diets, BRITISH JOURNAL OF NUTRITION, 114(11), 1774-1783, 20151214
  40. In vivo dose response and in vitro mechanistic analysis of enhanced immunoglobulin A production by Lactobacillus plantarum AYA., Biosci Microbiota Food Health, 34(3), 53-58, 20150314
  41. A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(5), 2902-2918, 20150130
  42. Modulatory activity of Lactobacillus rhamnosus OLL2838 in a mouse model of intestinal immunopathology, IMMUNOBIOLOGY, 220(6), 701-710, 2015
  43. Fructooligosaccharide augments benefits of quercetin-3-O-beta-glucoside on insulin sensitivity and plasma total cholesterol with promotion of flavonoid absorption in sucrose-fed rats, EUROPEAN JOURNAL OF NUTRITION, 53(2), 457-468, 2014
  44. Quercetin increases claudin-4 expression through multiple transcription factors in intestinal Caco-2 cells, JOURNAL OF FUNCTIONAL FOODS, 10, 112-116, 2014
  45. Bifidobacterium longum Alleviates Dextran Sulfate Sodium-Induced Colitis by Suppressing IL-17A Response: Involvement of Intestinal Epithelial Costimulatory Molecules, PLOS ONE, 8(11), 20131108
  46. Effects of a Chicken Collagen Hydrolysate on the Circulation System in Subjects with Mild Hypertension or High-Normal Blood Pressure, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 77(4), 691-696, 2013
  47. Regulation of intestinal epithelial permeability by tight junctions, CELLULAR AND MOLECULAR LIFE SCIENCES, 70(4), 631-659, 2013
  48. Comparative Analyses of Anti-hypertensive Effects of Commercial Collagen Peptides in Spontaneously Hypertensive Rats, JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, 60(3), 142-147, 2013
  49. Supplemental Naringenin Prevents Intestinal Barrier Defects and Inflammation in Colitic Mice, JOURNAL OF NUTRITION, 143(6), 827-834, 2013
  50. Dietary polyphenols modulate intestinal barrier defects and inflammation in a murine model of colitis, JOURNAL OF FUNCTIONAL FOODS, 5(2), 949-955, 2013
  51. Naringenin enhances intestinal barrier function through the expression and cytoskeletal association of tight junction proteins in Caco-2 cells, MOLECULAR NUTRITION & FOOD RESEARCH, 57(11), 2019-2028, 2013
  52. Hesperidin inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice by suppressing Th17 activity, JOURNAL OF FUNCTIONAL FOODS, 5(4), 1633-1641, 2013
  53. Regulation of intestinal barrier function by dietary polyphenols., Current Nutrition and Food Science, 9, 85-92, 2013
  54. Differential Effects of Flavonoids on Barrier Integrity in Human Intestinal Caco-2 Cells, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 60(18), 4628-4633, 20120509
  55. Effect of D-Alanine in Teichoic Acid from the Streptococcus thermophilus Cell Wall on the Barrier-Protection of Intestinal Epithelial Cells, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 76(2), 283-288, 2012
  56. Suppression of Th17 response by Streptococcus thermophilus ST28 through induction of IFN-gamma, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 28(5), 817-822, 2011
  57. Streptococcus thermophilus ST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 Cells, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011
  58. Kaempferol Enhances Intestinal Barrier Function through the Cytoskeletal Association and Expression of Tight Junction Proteins in Caco-2 Cells, JOURNAL OF NUTRITION, 141(1), 87-94, 2011
  59. Role of flavonoids in intestinal tight junction regulation, JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 22(5), 401-408, 2011
  60. Ingestion of epilactose, a non-digestible saccharide, improves postgastrectomy osteopenia and anemia in rats through the promotion of intestinal mineral absorption. - Comparative analyses of two non-digestible saccharides, epilactose and fructooligosaccharide -, Journal of Applied Glycoscience Supplement, 2011(0), 74-74, 2011
  61. Ingestion of Epilactose, a Non-digestible Disaccharide, Improves Postgastrectomy Osteopenia and Anemia in Rats through the Promotion of Intestinal Calcium and Iron Absorption, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 58(19), 10787-10792, 20101013
  62. Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats, NUTRITION & METABOLISM, 7, 20100312
  63. Phytate hydrolysate induces circumferential F-actin ring formation at cell-cell contacts by a Rho-associated kinase-dependent mechanism in colorectal cancer HT-29 cells, MOLECULAR NUTRITION & FOOD RESEARCH, 54(12), 1807-1818, 2010
  64. Effects of DFA IV in Rats : Calcium Absorption and Metabolism of DFA IV by Intestinal Microorganisms, Bioscience, biotechnology, and biochemistry, 63(4), 655-661, 19990423
  65. 3,5,7,3 ',4 '-Pentamethoxyflavone Enhances the Barrier Function through Transcriptional Regulation of the Tight Junction in Human Intestinal Caco-2 Cells, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69(35), 10174-10183, 20210908
  66. Hydrogen sulfide suppresses the proliferation of intestinal epithelial cells through cell cycle arrest, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 712, 20211115
  67. Ammonia impairs tight junction barriers by inducing mitochondrial dysfunction in Caco-2 cells, FASEB JOURNAL, 35(11), 202111
  68. Supplemental Leuconostoc mesenteroides strain NTM048 attenuates imiquimod-induced psoriasis in mice, JOURNAL OF APPLIED MICROBIOLOGY, 131(6), 3043-3055, 202112

Invited Lecture, Oral Presentation, Poster Presentation

  1. Significance and dietary regulation of intestinal epithelial tight junction barrier, Takuya Suzuki, 2020/09/04, With Invitation, Japanese, experimental
  2. Dietary fermentable fibers reduce the chronic kidney disease through protecting intestinal barrier, Takuya Suzuki, International Medicine & Health Sciences Congress 2019, 2019/12/27, Without Invitation, English, France, Paris
  3. Dietary fermentable fibers increase intestinal heat shock protein70 through short chain fatty acids production, Adesina Precious Adedayo, Takuya Suzuki, ICoFF2019/ISNFF2019, 2019/12/03, Without Invitation, English
  4. Citrus kawachiensis Peel Powder Reduces Intestinal Barrier Defects and Inflammation in Colitic Mice, 2019/05/17, Without Invitation, Japanese
  5. Resveratrol Enhances Intestinal Barrier Function and Ameliorates the Hydrogen Peroxide-Induced Epithelial Barrier Disruption., Mayangsari Y,Suzuki T, Indonesian society for functional food and nutraceutical, 2017/03, With Invitation, English
  6. Dietary Fermentable Fiber Reduces Intestinal Barrier Defects and Inflammation in Colitic Mice, Hung TV and Takuya S, 2016/11, Without Invitation, English
  7. Fermentable Fiber Reduces Intestinal Barrier Defects and Inflammation in Colitic Mice., Hung TV, Takuya S, International Society of Nutraceuticals and Functional Foods, 2016/10/09, Without Invitation, English
  8. Cellular zinc is required for intestinal epithelial barrier maintenance via the regulation of claudin-3 and occludin expression., Yuka M, Takuya S, United European Gastroenterology Week, 2016/10, Without Invitation, English, Austria
  9. Barrier Recovering-function of a Gut Microbial Metabolite of Linoleic Acid, Junki Miyamoto, Shigenobu Kishino, Takuya Suzuki, Jun Ogawa, Ikuo Kimura, Soichi Tanabe, 107th AOCS Annual Meeting & Expo, 2016/05, Without Invitation, English
  10. A gut microbial metabolite of linoleic acid and gut homeostasis, Junki Miyamoto, Shigenobu Kishino, Takuya Suzuki, Jun Ogawa, Ikuo Kimura, Soichi Tanabe,, Experimental Biology, 2016/04, Without Invitation, English
  11. Intestinal barrier and the regulation by food factors, Takuya Suzuki, Ajinomoto seminar, 2015/09/29, With Invitation, Japanese, Ajinomoto
  12. Regulation of intestinal barrier by dietary polyphenols, Takuya Suzuki, 2015/09/09, With Invitation, English
  13. Novel functional food factors to regulate intestinal barrier function, Takuya Suzuki, 2015/07/03, With Invitation, Japanese
  14. Intestinal barrier regulation by dietary polyphenols., Takuya Suzuki, International Society Nutraceuticals and Food Factors Annual conference, 2012, With Invitation, English, Hawai, USA

Awards

  1. 2016/10/18, Oral free paper prize United European Gastroenterology Week2016, President of ueg

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2013, 2015
  2. KAKENHI, 2012, 2014
  3. KAKENHI, Protective role of flavonoids in the stress-induced intestinal barrier dysfunction, 2011, 2012
  4. KAKENHI, Analysis of impairment and recovery mechanism of intestinal barrier and its application for design of foods with barrier-protectingactivity, 2010, 2012
  5. KAKENHI, Characterization of intestinal barrier defect in metabolic syndrome and the ameliorative effect of food factors, 2009, 2010
  6. KAKENHI, 2016, 2018
  7. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2019, 2021
  8. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2022, 2024