MISAKO OKUMURA

Last Updated :2024/02/02

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
Web Site
E-mail
okumuramhiroshima-u.ac.jp
Other Contact Details
Kagamiyama 1-3-1, Higashihiroshima, Hiroshima, Japan
TEL : (+81)82-424-7445 FAX : (+81)
Self-introduction
I am interested in the diversity of behavior. Using nematodes as model animals, I have been studying the function, development and evolution of neural circuits that regulate diverse behaviors.

Basic Information

Major Professional Backgrounds

  • 2012/04/01, 2015/03/31, University of Tokyo, Graduate School of Pharmaceutical Sciences, JSPS Research Fellow
  • 2015/04/01, 2015/05/15, University of Tokyo, Graduate School of Pharmaceutical Sciences, Research fellow
  • 2015/05/20, 2016/04/30, Max Planck Institute for Developmental Biology, Department for Evolutionary Biology, Postdoctoral fellow
  • 2016/05/01, 2017/03/19, Max Planck Institute for Developmental Biology, Department for Evolutionary Bilolgy, JSPS Overseas Research Fellow
  • 2017/04/01, 2019/03/31, Hiroshima University, Graduate School of Science, Assistant professor
  • 2019/04/01, 2021/03/31, Hiroshima University, Graduate School of Integrated Sciences for Life, Assistant Professor
  • 2021/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Associate Professor

Educational Backgrounds

  • University of Tokyo, Graduate School of pharmaceutical Sciences, Doctoral Program (Department of Pharmaceutical Sciences), 2012, 2015
  • University of Tokyo, Graduate School of Pharmaceutical Sciences, Master's Program (Department of Pharmaceutical Sciences), 2010, 2012
  • University of Tokyo, Faculty of Pharmaceutical Sciences, 2008, 2010
  • University of Tokyo, College of Arts and Sciences, Natural Sciences Ⅰ, 2006, 2008

Academic Degrees

  • Master, The University of Tokyo
  • PhD, The University of Tokyo

Educational Activity

  • [Bachelor Degree Program] School of Science : Biological Sciences : Biology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

Research Fields

  • Biology;Biological Science;Molecular biology
  • Biology;Biological Science;Developmental biology
  • Biology;Basic biology;Evolutionary biology

Research Keywords

  • Phenotypic Plasticity, Nematode, Behavior, Development, Evolution, Light, Photoreceptor

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2023, Liberal Arts Education Program1, 3Term, Introduction to Biology
  2. 2023, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  3. 2023, Undergraduate Education, 2Term, Advanced Biology
  4. 2023, Undergraduate Education, 1Term, Basic Biological Science A
  5. 2023, Undergraduate Education, 1Term, Cell Biology B
  6. 2023, Undergraduate Education, Second Semester, Seminar for Cell Biology
  7. 2023, Undergraduate Education, First Semester, Special Study for Graduation
  8. 2023, Undergraduate Education, Second Semester, Special Study for Graduation
  9. 2023, Undergraduate Education, Second Semester, Practice for Fundamental Biology II
  10. 2023, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  11. 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Basic Biology
  12. 2023, Graduate Education (Master's Program) , First Semester, Exercises in Basic Biology A
  13. 2023, Graduate Education (Master's Program) , Second Semester, Exercises in Basic Biology B
  14. 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  15. 2023, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  16. 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
  17. 2023, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
  18. 2023, Graduate Education (Master's Program) , First Semester, Exercises in Biomedical Science A
  19. 2023, Graduate Education (Master's Program) , Second Semester, Exercises in Biomedical Science B
  20. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  21. 2023, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  22. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  23. 2023, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E
  24. 2023, Graduate Education (Master's Program) , 4Term, Introduction to Genetics and Genomics

Research Activities

Academic Papers

  1. Dynamin-2 regulates microtubule stability via an endocytosis- independent mechanism, Cytoskeleton, 2022
  2. Ubiquitin proteasome system in circadian rhythm and sleep homeostasis: Lessons from Drosophila, GENES TO CELLS, 27(6), 381-391, 202206
  3. Endoplasmic reticulum proteins Meigo and Gp93 govern dendrite targeting by regulating Toll-6 localization, DEVELOPMENTAL BIOLOGY, 484, 30-39, 202204
  4. Systemic innate immune response induces death of olfactory receptor neurons in Drosophila, GENES TO CELLS, 27(2), 113-123, 202202
  5. ★, Efficient visual screening of CRISPR/Cas9 genome editing in the nematode Pristionchus pacificus, DEVELOPMENT GROWTH & DIFFERENTIATION, 63(9), 488-500, 202112
  6. Spatial transcriptomics of nematodes identifies sperm cells as a source of genomic novelty and rapid evolution, Molecular Biology and Evolution, 38, 229-243, 2021
  7. Amyotrophic lateral sclerosis-associated VAP33 is required for maintaining neuronal dendrite morphology and organelle distribution in Drosophila, Genes to Cells, 26, 230-239, 2021
  8. ★, Different combinations of serotonin receptors regulate predatory and bacterial feeding behaviors in the nematode Pristionchus pacificus, G3:Genes, Genomes, Genetics, 11(2), jkab011, 2021
  9. Impairment of cytokinesis by cancer-associated DAPK3 mutations, Biochemical and Biophysical Research Communications, 533(4), 1095-1101, 20201217
  10. ★, Serotonergic modulation of feeding behavior in Caenorhabditis elegans and other related nematodes, Neuroscience Research, 154, 9-19, 2020
  11. ★, Screening for CRISPR/Cas9-induced mutations using a co-injection marker in the nematode Pristionchus pacificus, Development Genes and Evolution, 230(3), 257-264, 2020
  12. ★, Serotonin Drives Predatory Feeding Behaviour via Synchronous Feeding Rhythms in the Nematode Pristionchus pacificus, G3-GENES GENOMES GENETICS, 7(11), 3745-3755, 201711
  13. Assaying Predatory Feeding Behaviors in Pristionchus and Other Nematodes, Journal of Visualized Experiments, e54404, 2016
  14. Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development, Neural Regeneration Research, 11(9), 1934-1935, 2016
  15. ★, Hierarchical axon targeting of Drosophila olfactory receptor neurons specified by the proneural transcription factors Atonal and Amos, Genes to Cells, 21, 53-64, 2016
  16. A STRIPAK component Strip regulates neuronal morphogenesis by affecting microtubule stability, Scientific Reports, 5, 17769, 2015
  17. The roles of tubulin-folding cofactors in neuronal morphogenesis and disease, Neural Regeneration Research, 10(9), 1388-1389, 2015
  18. ★, Linking Cell Surface Receptors to Microtubules: Tubulin Folding Cofactor D Mediates Dscam Functions during Neuronal Morphogenesis, The Journal of Neuroscience, 35(5), 1979-1990, 2015

Invited Lecture, Oral Presentation, Poster Presentation

  1. Regulation and evolutionary mechanisms of predatory behavior in the nematode Pristionchus pacificus, Misako Okumura, 2022/12/10, With Invitation, Japanese
  2. Light exposure during development influences the mouth form dimorphism in the nematode Pristionchus pacificus, Ageha Onodera, Hirokuni Hiraga, Yuuki Ishita, Ken-ichi Nakayama, Chinatsu Kai, Takahiro Chihara, Misako Okumura, 3rd Franco-Japanese Developmental Biology meeting, 2022/11/07, Without Invitation, English
  3. Molecular and neural mechanisms of light avoidance behavior in the nematode Pristionchus pacificus, 2022/10/05, Without Invitation, Japanese
  4. An astacin metalloprotease is required for predation in the nematode Pristionchus pacificus, Misako Okumura, Asia-Pacific Worm Meeting 2022, 2022/07/18, With Invitation, English, Online
  5. The evolution of multiple traits associated with a derivative feeding habit is mediated by co-option of an astacin metalloprotease in the nematode Pristionchus pacificus, Yuuki Ishita, Takahiro Chihara, Misako Okumura, 2022/05/31, Without Invitation, English
  6. Forward genetic screening to understand the molecular mechanism responding to light in P. pacificus, Ken-ichi Nakayama, Ageha Onodera, Chinatsu Kai, Takahiro Chihara, Misako Okumura, 2nd International Pristionchus meeting, 2021/10/13, Without Invitation, English
  7. Exposure of light affects the mouth form dimorphism in the nematode Pristionchus pacificus, Chinatsu Kai, Takahiro Chihara, Misako Okumura, 2021/06/17, Without Invitation, Japanese
  8. CRISPR/Cas9 injection marker in the nematode Pristionchus pacificus, Misako Okumura, Ken-ichi Nakayama, Yuuki Ishita, Takahiro Chihara, Future of the Nematodes Studies 2019, 2019/08/21, Without Invitation, Japanese
  9. Screening for CRISPR/Cas9-induced mutations using microchip electrophoresis in the nematode Pristionchus pacificus, Misako Okumura, Yuuki Ishita, Ken-ichi Nakayama, Takahiro Chihara, 22nd International C. elegans Conference, 2019/06/20, Without Invitation, English, Los Angeles, USA
  10. Neural mechanism of predatory feeding behavior in nematode Pristionchus pacificus, Misako Okumura, Yuuki Ishita Ralf J Sommer Takahiro Chihara, The 41st Annual Meeting of the Molecular Biology Society of Japan, 2018/11/28, Without Invitation, Japanese, Yokohama, Japan
  11. Neuro Evo Devoモデルとしての線虫Pristionchus pacificusの魅力と展望, Misako Okumura, Future of the nematodes studies, 2018/09/14, Without Invitation, Japanese, Mishima
  12. Neural regulation of the predatory feeding behavior in Pristionchus pacificus, Misako Okumura, Yuuki Ishita, Ralf J Sommer, Takahiro Chihara, 8th Asia Pacific Worm Meeting, 2018/07/09, Without Invitation, English, Korea, Seoul
  13. Function of Serotonin in Regulation of Predatory Feeding Behavior in the Nematode Pristionchus pacificus, Misako Okumura, Martin Wilecki, Ralf Sommer, 2017/12/06, Without Invitation, English
  14. Serotonin regulates predatory feeding behavior in nematode Pristionchus pacificus, Misako Okumura, Martin Wilecki, Ralf J Sommer, 2017/09/21, Without Invitation, Japanese
  15. Serotonin is required for Efficient Predatory Feeding by Pristionchus pacificus Predators., Misako Okumura, Lightfoot, J.W., Wilecki, M., Sommer, R. J, C. elegans Topic Meeting: Neuronal development, Synaptic function and Behavior, 2016/08/27, Without Invitation, English, Nagoya, Japan
  16. Serotonin regulates dynamic feeding mode switching inducing predatory kinetics in Pristionchus pacificus., Misako Okumura, James W. Lightfoot, Martin Wilecki, Ralf J. Sommer, 20th International C.elegans meeting, 2015/06/24, Without Invitation, English, Los Angels, USA
  17. Tubulin folding cofactor D cooperates with Dscam during neuronal morphogenesis, Misako Okumura, Sakuma, C., Miura M., Chihara T, European Fly Neurobiology, 2014/10/05, Without Invitation, English, Crete, Greece
  18. Tubulin folding cofactor D regulates neuronal morphogenesis by mediating Dscam functions, Misako Okumura, Sakuma, C., Miura, M., Chihara, T, Japanese Drosophila Research Conference 11, 2014/06/04, Without Invitation, English, Kanazawa, Japan
  19. Linking cell surface receptor to microtubule: Tubulin folding cofactor D mediates Dscam functions during neuronal morphogenesis, Misako Okumura, Sakuma, C., Miura, M., Chihara, T, 55th Annual Drosophila Research Conference, 2014/03/26, Without Invitation, English, San Diego, USA
  20. Role of tubulin folding pathway in neurite morphogenesis of Drosophila olfactory projection neuron, Misako Okumura, Miura, M., Chihara, T, The 46th Annual Meeting for the Japanese Society of Developmental Biologists, 2013/05/28, Without Invitation, English, Matsue, Japan
  21. Role of PCP signal molecule Four-jointed in dendrite morphogenesis of olfactory projection neuron., Misako Okumura, Miura, M., Chihara, T, Japanese Drosophila Research Conference 10, 2012/10/13, Without Invitation, English, Tokyo, Japan
  22. PCP signal molecule Four-jointed is involved in dendrite morphogenesis of olfactory projection neuron, Misako Okumura, Miura, M., Chihara, T., 14th European Drosophila Neurobiology Meeting, 2012/09/03, Without Invitation, English, Padua, Italy
  23. Role of PCP signal molecule Four-jointed in dendrite targeting of Drosophila olfactory projection neuron, Misako Okumura, Miura, M., Chihara, T, Joint Meeting of The 45th Annual Meeting for the Japanese Society of Developmental Biologists and The 64th Annual Meeting of the Japan Society for Cell Biology, 2012/05/28, Without Invitation, Japanese, Kobe, Japan
  24. Role of PCP protein Dachsous in the neural wiring of Drosophila olfactory system, Misako Okumura, Miura, M., Chihara, T, The 34th Annual Meeting of the Japan Neuroscience Society, 2011/09/14, Without Invitation, Japanese, Yokohama, Japan
  25. Role of a PCP protein Dachsous in Dendritic Targeting of Olfactory Projection Neurons, Misako Okumura, Miura, M., Chihara, T., 1st Asia-Pacific Drosophila Research Conference, 2011/05/22, Without Invitation, English, Taipei, Taiwan
  26. PCP protein Dachsous is required for dendritic targeting of olfactory projection neurons in Drosophila, Misako Okumura, Miura, M., Chihara, T, The 44th Annual Meeting for the Japanese Society of Developmental Biologists, 2011/05/18, Without Invitation, Japanese, Okinawa, Japan

Awards

  1. 2020, Encouragement Award, Hiroshima University, Graduate School of Integrated Sciences for Life
  2. 2018/09/14, Next Leaders Awards, Future of the nematodes studies

External Funds

Acceptance Results of Competitive Funds

  1. FOREST, 2023, 2025
  2. 2021, 2021
  3. Grant-in-Aid for Young Scientists, 2020, 2021
  4. Tomizawa Jun-ichi & Keiko Fund of Molecular Biology Society of Japan for Young Scientist, The molecular and neural mechanism of nematode light avoidance behavior, 2019, 2020
  5. AMED-PRIME, Molecular and neural mechanism of polyphenism responding to light, 2019, 2022
  6. JSPS Grands-in-Aid for Early-Career Scientists, 2018, 2019
  7. The Hiroshima University Education and Research Support Foundation, 2017, 2018
  8. Sumitomo Foundation, 2017, 2018
  9. Hiroshima University, 2017, 2017

Social Activities

Organizing Academic Conferences, etc.

  1. Future of the nematodes studies 2021, Main organizer, 2021/08, 2021/09
  2. 23rd International C. elegans Conference, Organizing Committee, 2021/06, 2021/06
  3. Future of the nematodes studies, Organizer, 2019/08, 2019/08

History as Peer Reviews of Academic Papers

  1. 2022, Journal of Cannabis Research, Others, Reviewer, 1
  2. 2022, Insect science, Others, Insect science, 1
  3. 2020, Proceedings of The Royal Society B, Others, Peer Reviews, 1