TOMOHARU YOKOOJI

Last Updated :2025/06/14

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Associate Professor
E-mail
yokoojihiroshima-u.ac.jp
Self-introduction
To obtain the efficacy of drugs maximally, we need to understand the pathology of disease and select the appropriate drugs. In our laboratory, we are trying to evaluate the pathogenesis of food allergy.

Basic Information

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Medicinal Sciences : Medicinal Sciences
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Pharmaceutical Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Medical pharmacy

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, First Semester, Research Practice A
  2. 2025, Undergraduate Education, Second Semester, Research Practice B
  3. 2025, Undergraduate Education, First Semester, Practice of Clinical Pharmacy
  4. 2025, Undergraduate Education, 1Term, Pharmacotherapy B
  5. 2025, Undergraduate Education, 3Term, Clinical Medicine and Pharmacotherapy III
  6. 2025, Undergraduate Education, 1Term, Clinical Pharmacology B
  7. 2025, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  8. 2025, Undergraduate Education, 3Term, Pharmacy Practice
  9. 2025, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  10. 2025, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  11. 2025, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  12. 2025, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  13. 2025, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  14. 2025, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  15. 2025, Graduate Education (Doctoral Program) , 4Term, Pharmacotherapeutic Research
  16. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Pharmaceutical Services
  17. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Pharmaceutical Services
  18. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Pharmaceutical Services
  19. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Pharmaceutical Services

Research Activities

Academic Papers

  1. Adipose-Derived Mesenchymal Stromal/Stem Cells Reduce Inflammatory Responses and Partially Alleviate Skin Symptoms in Imiquimod-Induced Psoriasis-Like Dermatitis Model Mice, Biological and Pharmaceutical Bulletin, 48(6), 812-824, 2025
  2. Tissue Distribution of Methylmercury in Obese Pregnant Mice and Fetuses, Journal of Applied Toxicology, 45(7), 1305-1313, 2025
  3. Elucidation of Desensitization Mechanisms Induced by Oral Immunotherapy in a Rat Model of Ovalbumin Allergy, Foods, 14(8), 1424, 2025
  4. Assessment of Risk of Acidosis in Patients with Mild-to-Moderate Chronic Kidney Disease Treated with Intravenous Branched-Chain Amino Acid-Enriched Solution: A Propensity Score Matching Analysis, Biological and Pharmaceutical Bulletin, 48(1), 46-50, 2025
  5. Evaluation of a Novel Detection Method for Allergen-Specific IgE Antibodies with IgE Receptor Crosslinking Using Rat Food Allergy Model, Foods, 13(17), 2713, 2024
  6. Assessment of the Safety of Exposure to Cefcapene Pivoxil during the First Trimester of Pregnancy: A Prospective Cohort Study in Japan, Biological and Pharmaceutical Bulletin, 47(7), 1301-1306, 2024
  7. A novel test for type-I allergy based on crosslink formation of immunoglobulin-E receptors by allergen-specific immunoglobulin-E antibodies and an allergen, Scientific Reports, 13(1), 19676, 2023
  8. Comparison of Berberine Bioavailability between Oral and Rectal Administrations in Rats, Biological and Pharmaceutical Bulletin, 46(11), 1639-1642, 2023
  9. A Narrative Mini Review on Current Status of Hypoallergenic Wheat Development for IgE-Mediated Wheat Allergy, Wheat-Dependent Exercise-Induced Anaphylaxis, Foods, 12(5), 954, 2023
  10. Classification of Skin Injury Risk Caused by Extravasation of Electrolyte Solutions or Infusions in a Rat Model, Biological and Pharmaceutical Bulletin, 45(9), 1254-1258, 2022
  11. Hypoallergenic Wheat Line (1BS-18H) Lacking omega5-Gliadin Induces Oral Tolerance to Wheat Gluten Proteins in a Rat Model of Wheat Allergy, Foods, 11(15), 2181, 2022
  12. Emerging Anti-Inflammatory Pharmacotherapy and Cell-Based Therapy for Lymphedema, International Journal of Molecular Sciences, 23(14), 7614, 2022
  13. A novel detection method for cross-linking of IgE-receptors by autoantibodies in chronic spontaneous urticaria, Allergology International, 71(1), 94-102, 2022
  14. Identification of peroxidase-1 and beta-glucosidase as cross-reactive wheat allergens in grass pollen-related wheat allergy, Allergology International, 70(2), 215-222, 2021
  15. Identification of allergens for food-dependent exercise-induced anaphylaxis to shrimp, Scientific Reports, 11(1), 5400, 2021
  16. Interleukin-8 release inhibitors generated by fermentation of Artemisia princeps Pampanini herb extract with Lactobacillus plantarum SN13T, Frontiers in Microbiology, 11, 1159, 2020
    Link to Paper Search Results by DOI
  17. Exercise-induced allergic reactions on desensitization to wheat after rush oral immunotherapy, Allergy, 75(6), 1414-1422, 2020
  18. ★, Aspirin enhances sensitization to the egg-white allergen ovalbumin in rats, PLos One, 14(12), e0226165, 2019
  19. Evaluation of the allergenicity of omega5-gliadin-deficient Hokushin wheat (1BS-18) in a wheat allergy rat model, Biochemistry and Biophysics Reports, 20, 100702, 2019
  20. Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic beta-cells, Scientific Reports, 9(1), 16438, 2019
  21. Development of a liquid chromatography-tandem mass spectrometry method for quantification of the egg allergen ovalbumin in rat plasma, Allergology International, 68(3), 372-374, 2019
  22. ★, Intestinal absorption of the wheat allergen gliadin in rats, Allergology International, 68(2), 247-253, 2019
  23. Quantification of the omega5- and gamma-gliadin content in wheat flour and rat plasma with an enzyme-linked immunosorbent assay using antibodies specific to their IgE-binding epitopes, Allergology International, 68(1), 112-113, 2019
  24. Food-dependent exercise-induced anaphylaxis due to shrimp associated with 43 kDa, a new antigen, The Journal of Dermatology, 45(3), 366-367, 2018
  25. Evaluation of Risk of Injury by Extravasation of Hyperosmolar and Vasopressor Agents in a Rat Model, Biological and Pharmaceutical Bulletin, 41(6), 951-956, 2018
  26. INSOLUBILITY AND ALTERATION OF ALLERGENIC ACTIVITY OF WHEAT PROTEINS IN PROCESSED FOODS., Arerugi, 66(3), 222-230, 2017
  27. Anaphylaxis provoked by ingestion of hydrolyzed fish collagen probably induced by epicutaneous sensitization, Allergology International, 65(4), 474-476, 2016
  28. Injury due to extravasation of thiopental and propofol: Risks/effects of local cooling/warming in rats, Biochemistry and Biophysics Reports, 8, 207-211, 2016
  29. Prevalences of specific IgE to wheat gliadin components in patients with wheat-dependent exercise-induced anaphylaxis, Allergology International, 64(2), 206-208, 2015
  30. Case of food-dependent exercise-induced anaphylaxis due to Japanese apricot and peach: Detection of causative antigens, The Journal of Dermatology, 42(9), 916-917, 2015
  31. Sodium cromoglycate prevents exacerbation of IgE-mediated food-allergic reaction induced by aspirin in a rat model of egg allergy, International Archives of Allergy and Immunology, 167(3), 193-202, 2015
    Link to Paper Search Results by DOI
  32. Common food allergens and their IgE-binding epitopes, Allergology International, 64(4), 332-343, 2015
    Link to Paper Search Results by DOI
  33. Intestinal absorption of food allergens and development of food allergic symptoms, Membrane, 40(5), 284-290, 2015
  34. Interaction of hydrophobic components in female urine before and after childbirth with P-glycoprotein in vitro, Pharmazie, 69(6), 430-436, 2014
    Link to Paper Search Results by DOI
  35. Characterization of Ovalbumin Absorption Pathways in the Rat Intestine, Including the Effects of Aspirin, Biological and Pharmaceutical Bulletin, 37(8), 1359-1365, 2014
    Link to Paper Search Results by DOI
  36. Effect of genistein, a natural soy isoflavone, on the pharmacokinetics and intestinal toxicity of irinotecan hydrochloride in rats, Journal of Pharmacy and Pharmacology, 65(2), 280-291, 2013
  37. Role of ABC Efflux Transporters in the Oral Bioavailability and Drug-induced Intestinal Toxicity, Yakugaku Zasshi, 133(7), 815-822, 2013
    Link to Paper Search Results by DOI
  38. Intestinal absorption of lysozyme, an egg-white allergen, in rats: Kinetics and effect of NSAIDs, Biochemical and Biophysical research Communications, 438(1), 61-65, 2013
    Link to Paper Search Results by DOI
  39. Characterization of Causative Allergens for Wheat-Dependent Exercise-Induced Anaphylaxis Sensitized with Hydrolyzed Wheat Proteins in Facial Soap, Allergology International, 62(4), 435-445, 2013
    Link to Paper Search Results by DOI
  40. Aspirin Augments IgE-Mediated Histamine Release from Human Peripheral Basophils via Syk Kinase Activation, Allergology International, 62(4), 503-511, 2013
    Link to Paper Search Results by DOI
  41. Characterization of intestinal absorption of quinidine, a P-glycoprotein substrate, given as a powder in rats, Pharmazie, 67(5), 384-388, 2012
  42. Comparison of in vivo with in vitro pharmacokinetics of mercury between methylmercury chloride and methylmercury cysteine using rats and Caco2 cells, Arch Environ Contam Toxicol, 63(4), 628-636, 2012
  43. Modulated pharmacokinetics and increased small intestinal toxicity of methotrexate in bilirubin-treated rats, Journal of Pharmacy and Pharmacology, 63(2), 206-13-213, 2011
  44. Modulation in concentrative nucleoside transporters-mediated intestinal absorption of mizoribine, an immunosuppressive agent, in lipopolysaccharide-treated rats, Pharmazie, 66(3), 207-11-211, 2011
  45. Study on intestinal absorption sites of mizoribine and ribavirin, substrates for concentrative nucleoside transporter(s), in rats, European Journal of Pharmacology, 628(1-3), 214-9-219, 2010
  46. Modulated function of tissue efflux transporters under hyperbilirubinemia in rats, European Journal of Pharmacology, 636(1-3), 166-172, 2010
  47. Interaction of Rhei Rhizoma extract with cytochrome P450 3A and efflux transporters in rats, Pharmazie, 65(5), 367-74-374, 2010
  48. Study on absorption sites of quinidine and methotrexate in rat intestine, Pharmazie, 65(6), 440-447, 2010
  49. Increased intestinal absorption of mizoribine, an immunosuppressive agent, in cholestatic rats, Pharmazie, 65(7), 457-460, 2010
  50. Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats, Journal of Pharmacy and Pharmacology, 61(7), 911-8-918, 2009
  51. Characterization of intestinal absorption of mizoribine mediated by concentrative nucleoside transporters in rats, European Journal of Pharmacology, 586(1-3), 52-58, 2008
  52. Fate of quinidine, a P-glycoprotein substrate, in the gastrointestinal tract after oral administration in rats, Pharmazie, 63(3), 241-4-244, 2008
  53. Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells, Journal of Pharmacy and Pharmacology, 59(4), 513-520, 2007
  54. Role of intestinal efflux transporters in the intestinal absorption of methotrexate in rats, Journal of Pharmacy and Pharmacology, 59(9), 1263-1270, 2007
  55. Function of multidrug resistance-associated protein 2 in acute hepatic failure rats, European Journal of Pharmacology, 546(1-3), 152-60-160, 2006
  56. Modulation of intestinal transport of 2,4-dinitrophenyl-S-glutathione, a multidrug resistance-associated protein 2 substrate, by bilirubin treatment in rats, Journal of Pharmacy and Pharmacology, 57(5), 579-585, 2005

Invited Lecture, Oral Presentation, Poster Presentation

  1. Development Of A Novel Detection Method For Allergen-specific IgE Antibodies Which Cross-link IgE Receptors Using Sera From Patients With Type-I Allergy, Yuki Koga, Tomoharu Yokooji, Ryohei Ogino, Takanori Taogoshi, Daiki Matsubara, Kaori Ishii, Yuko Chinuki, Eishin Morita, Shunsuke Takahagi, Akio Tanaka, Hiroaki Matsuo, 2025 AAAAI/WAO Joint Congress, 2025/02/28, Without Invitation, English, San Diego, USA
  2. Evaluation of allergenicity of hypoallergenic wheat and its ability of oral tolerance induction to gluten proteins in a rat model of wheat allergy, Tomoharu Yokooji, Ryohei Ogino, Yuki Koga, Takanori Taogoshi, Eishin Morita, Hiroaki Matsuo, 2025 AAAAI/WAO Joint Congress, 2025/02/28, Without Invitation, English, San Diego, USA
  3. Maternal transfer of methylmercury in high-fat diet-induced obese mice with glucose metabolism disorder, Megumi Yamamotoa, Chisato Kataokaa, Rie Yanagisawab, Mayumi Tsujic, Eiji Shibatac, Tomoharu Yokoojid, Nobuhiro Morie, Masahisa Horiuchif, Satoshi Shutog, Masaaki Nakamuraa, Mineshi Sakamotoa, The Society of toxicology (SOT) 63rd Annual Meeting and ToxExpo, 2024/03/11, Without Invitation, English, Salt Lake City, USA
  4. Classification of Skin Injury Risk Caused by Extravasation of Electrolyte Solutions in a Rat Model, Takanori Taogoshi, Yuuka Shibata, Hiromi Uno, Tomoharu Yokooji, Maiko Tanaka, Michihiro Hide, Hiroaki Matsuo, The 21st Asian Conference on Clinical Pharmacy: ACCP 2022 in Nagoya, 2022/02/11, Without Invitation, English, Nagoya (online)
  5. Evaluation of the allergenicity and induction ability for oral tolerance of omega5-gliadin-deficient Hokushin wheat (1BS-18) in a wheat allergy rat model, Yukinori Yamada, Tomoharu Yokooji, Naoki Ninomiya, Takanori Taogoshi, Eishin Morita, Hiroaki Matsuo, JSA/WAO Joint Congress 2020, 2020/09/17, Without Invitation, English, Kyoto (online)
  6. Effects of non-steroidal anti-inflammatory drugs on sensitization to the egg-white allergen ovalbumin in rats, Takahiro Fukushima, Tomoharu Yokooji, Taiki Hirano, Yuta Kataoka, Takanori Taogoshi, Hiroaki Matsuo, JSA/WAO Joint Congress 2020, 2020/09/17, Without Invitation, English, Kyoto (online)
  7. Establishment of wheat peroxidase I-specific IgE test to identify wheat-dependent exercise-induced anaphylaxis developed by sensitization to grass pollen, Eishin Morita, Ryohei Ogino, Yuko Chinuki, Tomoharu Yokooji, Hiroaki Matsuo, 49th European Society for Dermatological Research (ESDR) Annual Meeting, 2019/09/18, Without Invitation, English, Bordeaux, France
  8. Olanzapine suppresses insulin secretion from pancreatic beta-cellls via blockage of multiple receptors, Mao Nagata, Tomoe Nakai, Yumika Miura, Takashi Tomita, Takanori Taogoshi, Tomoharu Yokooji, Yumi Sugimoto, Hiroaki Matsuo, 78th FIP World Congress of Pharmacy and Pharmaceutical Sciences, 2018/09/02, Without Invitation, English, Glasgow, UK
  9. Enhancing effect of aspirin on intestinal absorption of gliadin, wheat allergen, and its mechanism, Tomoharu Yokooji, Koh Hamura, Naoki Ninomiya, Takanori Taogoshi, Hiroaki Matsuo, 78th FIP World Congress of Pharmacy and Pharmaceutical Sciences, 2018/09/02, Without Invitation, English, Glasgow, UK
  10. Evaluation of risk for injury by extravasation of vasopressor and hyperosmolar agents in a rat model, Yuuka Shibata, Yumeka Sagara, Takanori Taogoshi, Tomoharu Yokooji, Hiroaki Matsuo, 18th World congress of basic and clinical pharmacology, 2018/07/01, Without Invitation, English, Kyoto, Japan
  11. Component-specific IgE levels were associated with intractable exercise-induced allergic reactions to wheat after rush oral immunotherapy, Komei Ito, Tomoko Furuta, Kazunori Tagami, Teruaki Matsui, Siro Sugiura, Naoyuki Kando, Akira Tanaka, Sigrid Sjölander, Tomoharu Yokooji, Hiroaki Matsuo, European Academy of Allergy and Clinical Immunology (EAACI) Congress 2018, 2018/05/26, Without Invitation, English, Munich, Germany
  12. Identification of allergens for wheat-dependent exercise-induced anaphylaxis developed by sensitization to grass pollen, Ryohei Ogino, Yuko Chinuki, Daigo Takizawa, Tomoharu Yokooji, Hiroaki Matsuo, Eishin Morita, International Investigative Dermatology (IID) 2018, 2018/05/16, Without Invitation, English, Rosen Shingle Creek, Orlando, Florida
  13. Occurrence and severity of skin injury caused by extravasation of cytotoxic and non-cytotoxic drugs, Shibata Y, Itamura R, Yokooji T, Tanaka M, Matsuo H, American Society of Hospital Pharmacist 2017 Midyear Clinical Meeting & Exhibition, 2017/12/05, Without Invitation, English, Orlando
  14. Aspirin facilitates the intestinal absorption and oral sensitization of food allergens in rats, Yokooji T, Hirano T, Matsuo H., World Allergy Congress (WAC) 2015, 2015/10/14, Without Invitation, English
  15. Characterization of the Causative Allergens for Wheat-dependent Exercise-induced Anaphylaxis Sensitized with Hydrolyzed Wheat Proteins in Facial Soap., Yokooji T, Kurihara S, Murakami T, Chinuki Y, Harada S, Takahashi H, Morita E, Ishii K, Hiragun M, Hide M, Matsuo H, American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting 2013, 2013, Without Invitation, English, San Antonio (USA)
  16. Aspirin Augments IgE-Mediated Histamine Release From Human Peripheral Basophils Via Syk Kinase Activation, Matsuo H, Yokooji T, Morita H, Ooi M, Urata K, Takahagi S, Ishii K, Yanase Y, Hiragun T, Mihara S, Hide M, 2013, Without Invitation, English