Takashi Yamamoto

Last Updated :2024/05/07

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
E-mail
tybighiroshima-u.ac.jp
Other Contact Details
1-3-1，Kagamiyama，Higashi-Hiroshima, Japan
TEL : (+81)824-24-7446 FAX : (+81)824-24-7498

Basic Information

Major Professional Backgrounds

  • 1992/08/01, 2002/05/31, Kumamoto University, Research Associate
  • 2002/06/01, 2003/10/31, Hiroshima University, Graduate School of Science, Lecturer
  • 2003/11/01, 2004/03/31, Hiroshima University, Graduate School of Science, Assistant Professor
  • 2004/04/01, 2019/03/31, Hiroshima University, Graduate School of Science, Professor
  • 2014/04/01, 2022/03/31, Tottori University, Visiting professor
  • 2014/04/01, 2022/03/31, Kumamoto University, Visiting professor
  • 2017/04/01, 2020/03/31, Collaborative Research Laboratory for Next Generation Automobile Technology, Professor
  • 2019/02/01, 2022/03/31, Genome Editing Innovation Center, Director of the center

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Natural Science, Japan, 1991/04, 1992/07
  • Hiroshima University, Graduate School, Division of Natural Science, Japan, 1989/04, 1991/03
  • Hiroshima University, Faculty of Science, Japan, 1985/04, 1989/03

Academic Degrees

  • Doctor of Science, Hiroshima University
  • Master of Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Science : Biological Sciences : Biology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Mathematical and Life Sciences
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Mathematical and Life Sciences
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

Research Fields

  • Biological Sciences;Genome science;Genome biology
  • Biological Sciences;Genome science;Medical genome science
  • Biological Sciences;Genome science;System genome science
  • Biology;Biological Science;Developmental biology

Research Keywords

  • Genome Editing
  • TALEN, CRISPR-Cas, ZFN
  • echinoderm
  • development
  • noise
  • gene regulatory network

Affiliated Academic Societies

  • The Japanese Society for Genome Editing, 2016

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 1Term, Fundamentals of Biology
  2. 2024, Undergraduate Education, 4Term, Introduction to Biological Sciences B
  3. 2024, Undergraduate Education, 2Term, Advanced Biology
  4. 2024, Undergraduate Education, 3Term, Developmental Biology A
  5. 2024, Undergraduate Education, Second Semester, Seminar for Molecular Genetics
  6. 2024, Undergraduate Education, First Semester, Special Study for Graduation
  7. 2024, Undergraduate Education, Second Semester, Special Study for Graduation
  8. 2024, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  9. 2024, Graduate Education (Master's Program) , 2Term, societal implementation of life science
  10. 2024, Graduate Education (Master's Program) , 1Term, Introduction to Life Science
  11. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Mathematical and Life Sciences
  12. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Mathematical and Life Sciences
  13. 2024, Graduate Education (Master's Program) , 2Term, Molecular Genetics
  14. 2024, Graduate Education (Master's Program) , 2Term, Topical Seminar in Life Science C
  15. 2024, Graduate Education (Master's Program) , 4Term, Topical Seminar in Life Science D
  16. 2024, Graduate Education (Master's Program) , First Semester, Exercises in Life Science A
  17. 2024, Graduate Education (Master's Program) , Second Semester, Exercises in Life Science B
  18. 2024, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  19. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  20. 2024, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  21. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
  22. 2024, Graduate Education (Master's Program) , First Semester, Exercises in Biomedical Science A
  23. 2024, Graduate Education (Master's Program) , Second Semester, Exercises in Biomedical Science B
  24. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  25. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  26. 2024, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E
  27. 2024, Graduate Education (Master's Program) , OutOfTerm(1st), Ethics of Genome Editing Research
  28. 2024, Graduate Education (Master's Program) , 2Term, Basics and Practical Applications of Genome Editing
  29. 2024, Graduate Education (Master's Program) , Second Semester, Clinical Applications of Genome Editing Technology

Research Activities

Academic Papers

  1. 3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migration, CELL REPORTS, 42(12), 20231226
    Link to Paper Search Results by DOI
  2. The crucial role of CTCF in mitotic progression during early development of sea urchin, DEVELOPMENT GROWTH & DIFFERENTIATION, 65(7), 395-407, 202309
    Link to Paper Search Results by DOI
  3. Robust protein-based engineering of hepatocyte-like cells from human mesenchymal stem cells, HEPATOLOGY COMMUNICATIONS, 7(3), 202303
    Link to Paper Search Results by DOI
  4. Development of a chub mackerel with less-aggressive fry stage by genome editing of arginine vasotocin receptor V1a2, SCIENTIFIC REPORTS, 13(1), 20230223
    Link to Paper Search Results by DOI
  5. Genome editing with removable TALEN vectors harboring a yeast centromere and autonomous replication sequence in oleaginous microalga, SCIENTIFIC REPORTS, 12(1), 20220215
    Link to Paper Search Results by DOI
  6. Panel of human cell lines with human/mouse artificial chromosomes, SCIENTIFIC REPORTS, 12(1), 20220222
    Link to Paper Search Results by DOI
  7. Gene manipulation in the Mucorales fungus Rhizopus oryzae using TALENs with exonuclease overexpression, FEMS MICROBIOLOGY LETTERS, 369(1), 20220222
    Link to Paper Search Results by DOI
  8. Role of the Nanos Homolog During Sea Urchin Development, DEVELOPMENTAL DYNAMICS, 238(10), 2511-2521, 200910
    Link to Paper Search Results by DOI
  9. Targeted mutagenesis in the sea urchin embryo using zinc-finger nucleases, GENES TO CELLS, 15(8), 875-885, 201008
    Link to Paper Search Results by DOI
  10. Nucleosome exclusion from the interspecies-conserved central AT-rich region of the Ars insulator, JOURNAL OF BIOCHEMISTRY, 151(1), 75-87, 201201
    Link to Paper Search Results by DOI
  11. Efficient targeted mutagenesis of the chordate Ciona intestinalis genome with zinc-finger nucleases, DEVELOPMENT GROWTH & DIFFERENTIATION, 54(5), 535-545, 201206
    Link to Paper Search Results by DOI
  12. Targeted disruption of exogenous EGFP gene in medaka using zinc-finger nucleases, DEVELOPMENT GROWTH & DIFFERENTIATION, 54(5), 546-556, 201206
    Link to Paper Search Results by DOI
  13. Equarin is involved as an FGF signaling modulator in chick lens differentiation, DEVELOPMENTAL BIOLOGY, 368(1), 109-117, 20120801
    Link to Paper Search Results by DOI
  14. ★, Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(27), 10915-10920, 20120703
    Link to Paper Search Results by DOI
  15. Non-transgenic genome modifications in a hemimetabolous insect using zinc-finger and TAL effector nucleases, NATURE COMMUNICATIONS, 3, 201208
    Link to Paper Search Results by DOI
  16. Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes, SCIENTIFIC REPORTS, 3, 20130213
    Link to Paper Search Results by DOI
  17. Enhancer activity sensitive to the orientation of the gene it regulates in the chordate genome, DEVELOPMENTAL BIOLOGY, 375(1), 79-91, 20130301
    Link to Paper Search Results by DOI
  18. Efficient Targeted Mutagenesis in Medaka Using Custom-Designed Transcription Activator-Like Effector Nucleases, GENETICS, 193(3), 739-+, 201303
    Link to Paper Search Results by DOI
  19. ★, Efficient TALEN construction and evaluation methods for human cell and animal applications, GENES TO CELLS, 18(4), 315-326, 201304
    Link to Paper Search Results by DOI
  20. Production of Sry knockout mouse using TALEN via oocyte injection, SCIENTIFIC REPORTS, 3, 20131105
    Link to Paper Search Results by DOI
  21. ★, Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity, SCIENTIFIC REPORTS, 3, 20131129
    Link to Paper Search Results by DOI
  22. TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS ( MVA) syndrome, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(4), 1461-1466, 20140128
    Link to Paper Search Results by DOI
  23. The Otx binding site is required for the activation of HpOtxL mRNA expression in the sea urchin, Hemicentrotus pulcherrimus, Development= Growth and Differentiation, 46(1), 20040201
  24. Cis-acting elements for proper ontogenic expression of arylsulfatase gene of sea urchin embryo, Development= Growth and Differentiation, 34(6), 719-729, 19920401
  25. cis-Elements and protein factors related to regulation of transcription of arylsulfatase gene during sea urchin development, Development= Growth and Differentiation, 35(6), 703-710, 19930401
  26. Corrected structure of the 5' flanking region of arylsulfatase gene of the sea urchin, Hemicentrotus pulcherrimus, Development= Growth and Differentiation, 36(6), 633-636, 19940401
  27. A triplex DNA structure of the polypyrimidine-polypurine stretch in the 5' flanking region of the sea urchin arylsulfatase gene, Zoological Science, 13, 105-109, 19960401
  28. Differential expression of annexin V during spermatogenesis in Cynops pyrrhogaster, Development Genes and Evolution, 206, 64-71, 19960401
  29. Expression of activin beta subunit genes in Sertoli cells of newt testes, Biochemical and Biophysical Research Communications, 224, 451-456, 19960401
  30. Genesis of axial fiber of newt sperm-cDNA cloning and expression of a 29 kDa protein, a major component of the axial fiber, during the spermatogenesis, International Journal of Developmental Biology, 40, 1109-1118, 19960401
  31. Cloning and expression of a cDNA encoding a prolactin receptor of the Japanese red-bellied newt, Cynops pyrrhogaster, Zoological Science, 15(5), 741-747, 19980401
  32. Cloning of cDNA for newt WT1 and the differential expression during spermatogenesis of the Japanese newt, Cynops pyrrhogaster, Development= Growth and Differentiation, 40(6), 599-608, 19980401
  33. Newt Rad51-Cloning of cDNA and analysis of gene expression during the spermatogenesis, Development= Growth and Differentiation, 41(4), 401-406, 19990401
  34. IGF-I, IGF-II and insulin promote differentiation of spermatogonia to primary spermatocytes in organ culture of newt testes, International Journal of Developmental Biology, 43(4), 343-348, 19990401
  35. Cloning of cDNA for Xenopus prolactin receptor and its metamorphic expression profile, Development= Growth and Differentiation, 42(2), 167-174, 20000401
  36. Prolactin induces apotosis in the penultimate spermatogonial stage of the testes in Japanese red-bellied Newt (Cynops pyrrhogaster), Endocrinology, 141(6), 2027-2032, 20000401
  37. Molecular cloning, functional characterization and gene expression of a follicle-stimulating hormone receptor in the testis of newt, Cynops pyrrhogaster, Biochemical and Biophysical Research Communications, 275(1), 121-128, 20000401
  38. Conversion from mitosis to meiosis-morphology and expression of PCNA and Dmc1 during newt spermatogenesis, Development= Growth and Differentiation, 42(2), 603-612, 20000401
  39. Caspase activity in newt spermatogonial apoptosis induced by prolactin and cycloheximide., Molecular Reproduction and Development, 52(2), 209-214, 20010401
  40. Cloning of dynein Intermediate chain cDNA of the newt Cynops pyrrhogaster, DNA Research, 8(2), 81-84, 20010401
  41. Cold Suppression of follicle-stimulating hormone activity on proliferation and survival of newt spermatogonia, General and Comparative Endocrinology, 122(3), 296-303, 20010401
  42. Mammalian follicle-stimulating hormone (FSH) and insulin-like growth factor I (IGF-I) up-regulate IGF-I gene expression in organ culture of newt testis, Molecular Reproduction and Development, 60(1), 56-64, 20010401
  43. Expression of a novel matrix metalloproteinase gene during Cynops early embryogenesis, Biochemical and Biophysical Research Communications, 288(2), 380-384, 20010401
  44. Follicle-stimulating hormone is indispensable for the last spermatogonial mitosis preceding meiosis initiation in newts(Cynops pyrrhogaster), Biology of Reproduction, 66(1), 14-20, 20020401
  45. Promotion of cathepsin L activity in newt spermatogonial apopotosis induced by prolactin, FEBS Letters, 521(1-3), 43-46, 20020401
  46. Human recombinant stem cell factor promotes spermatogonial proliferation, but not meiosis initiation in organ culture of newt testis fragments, Biochemical and Biophysical Research Communications, 294(3), 695-699, 20020401
  47. A long polypyrimidine-polypurine sequence in 5’ flanking region of arylsulfatase gene of sea urchin embryo, International Journal of Developmental Biology, 38, 337-344, 19940401
  48. Quantitative assay for TALEN activity at endogenous genomic loci, BIOLOGY OPEN, 2(4), 363-367, 20130415
    Link to Paper Search Results by DOI
  49. High efficiency TALENs enable F0 functional analysis by targeted gene disruption in Xenopus laevis embryos., Biol Open, 2, 448-452, 20130301
  50. T-brain homologue (HpTb) is involved in the archenteron induction signals of micromere descendant cells in the sea urchin embryo, DEVELOPMENT, 129(22), 5205-5216, 200211
    Link to Paper Search Results by DOI
  51. Utilization of a particle gun DNA introduction system for the analysis of cis-regulatory elements controlling the spatial expression pattern of the arylsulfatase gene (HpArs) in sea urchin embryos, DEVELOPMENT GENES AND EVOLUTION, 213(1), 44-49, 200302
    Link to Paper Search Results by DOI
  52. Abnormal spermatogenesis at low temperatures in the Japanese red-bellied newt, Cynops pyrrhogaster: Possible biological significance of the cessation of Spermatocytogenesis, MOLECULAR REPRODUCTION AND DEVELOPMENT, 66(1), 60-66, 200309
    Link to Paper Search Results by DOI
  53. Low temperature promotes annexin V expression in newt testis, ZOOLOGICAL SCIENCE, 20(6), 733-735, 200306
    Link to Paper Search Results by DOI
  54. Identification of two teleost homologs of the Drosophila sex determination factor, transformer-2 in medaka (Oryzias latipes), MECHANISMS OF DEVELOPMENT, 121(7-8), 991-996, 200407
    Link to Paper Search Results by DOI
  55. The Otx binding site is required for the activation of HpOtxL mRNA expression in the sea urchin, Hemicentrotus pulcherrimus, DEVELOPMENT GROWTH & DIFFERENTIATION, 46(1), 61-69, 200402
    Link to Paper Search Results by DOI
  56. Sexually dimorphic expression of a teleost homologue of Mullerian inhibiting substance during gonadal sex differentiation in Japanese flounder, Paralichthys olivaceus, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 322(2), 508-513, 20040917
    Link to Paper Search Results by DOI
  57. A new G-stretch-DNA-binding protein, Unichrom, displays cell-cycle-dependent expression in sea urchin embryos, DEVELOPMENT GROWTH & DIFFERENTIATION, 46(4), 335-341, 200408
    Link to Paper Search Results by DOI
  58. Developmental expression of HpNanos, the Hemicentrotus pulcherrimus homologue of nanos, GENE EXPRESSION PATTERNS, 6(5), 572-577, 200606
    Link to Paper Search Results by DOI
  59. Organ-specific and age-dependent expression of insulin-like growth factor-I (IGF-I) mRNA variants: IGF-IA and IB mRNAs in the mouse, ZOOLOGICAL SCIENCE, 22(9), 1011-1021, 200509
    Link to Paper Search Results by DOI
  60. Unichrom, a novel nuclear matrix protein, binds to the Ars insulator and canonical MARs, ZOOLOGICAL SCIENCE, 23(1), 9-21, 200601
    Link to Paper Search Results by DOI
  61. Analysis of cis-regulatory elements controlling spatio-temporal expression of T-brain gene in sea urchin, Hemicentrotus pulcherrimus, MECHANISMS OF DEVELOPMENT, 125(1-2), 2-17, 2008
    Link to Paper Search Results by DOI
  62. DNA variations within the sea urchin Otx gene enhancer, FEBS LETTERS, 581(27), 5234-5240, 20071113
    Link to Paper Search Results by DOI
  63. RSF governs silent chromatin formation via histone H2Av replacement, PLOS GENETICS, 4(2), 200802
    Link to Paper Search Results by DOI
  64. The Ars insulator facilitates I-SceI meganuclease-mediated transgenesis in the sea urchin embryo, DEVELOPMENTAL DYNAMICS, 237(9), 2475-2482, 200809
    Link to Paper Search Results by DOI
  65. Suppressor of Hairless (Su(H)) is Required for Foregut Development in the Sea Urchin Embryo, ZOOLOGICAL SCIENCE, 26(10), 686-690, 200910
    Link to Paper Search Results by DOI
  66. HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development, MECHANISMS OF DEVELOPMENT, 127(3-4), 235-245, 2010
    Link to Paper Search Results by DOI
  67. Dicer is Required for the Normal Development of Sea Urchin, Hemicentrotus pulcherrimus, ZOOLOGICAL SCIENCE, 27(6), 477-486, 201006
    Link to Paper Search Results by DOI
  68. Implication of HpEts in Gene Regulatory Networks Responsible for Specification of Sea Urchin Skeletogenic Primary Mesenchyme Cells, ZOOLOGICAL SCIENCE, 27(8), 638-646, 201008
    Link to Paper Search Results by DOI
  69. Mammalian arylsulfatase A functions as a novel component of the extracellular matrix, CONNECTIVE TISSUE RESEARCH, 51(5), 388-396, 201010
    Link to Paper Search Results by DOI
  70. HpSumf1 is involved in the activation of sulfatases responsible for regulation of skeletogenesis during sea urchin development, DEVELOPMENT GENES AND EVOLUTION, 221(3), 157-166, 201108
    Link to Paper Search Results by DOI
  71. The 3 ' UTR of nanos2 directs enrichment in the germ cell lineage of the sea urchin, DEVELOPMENTAL BIOLOGY, 377(1), 275-283, 20130501
    Link to Paper Search Results by DOI
  72. Screening Methods to Identify TALEN-Mediated Knockout Mice, EXPERIMENTAL ANIMALS, 63(1), 79-84, 201401
    Link to Paper Search Results by DOI
  73. Targeted mutagenesis of multiple and paralogous genes in Xenopus laevis using two pairs of transcription activator-like effector nucleases, DEVELOPMENT GROWTH & DIFFERENTIATION, 56(1), 108-114, 201401
    Link to Paper Search Results by DOI
  74. Transcription activator-like effector nucleases efficiently disrupt the target gene in Iberian ribbed newts (Pleurodeles waltl), an experimental model animal for regeneration, DEVELOPMENT GROWTH & DIFFERENTIATION, 56(1), 115-121, 201401
    Link to Paper Search Results by DOI
  75. Versatile strategy for isolating transcription activator-like effector nuclease-mediated knockout mutants in Caenorhabditis elegans, DEVELOPMENT GROWTH & DIFFERENTIATION, 56(1), 78-85, 201401
    Link to Paper Search Results by DOI
  76. TALEN-induced gene knock out in Drosophila, DEVELOPMENT GROWTH & DIFFERENTIATION, 56(1), 86-91, 201401
    Link to Paper Search Results by DOI
  77. Targeted mutagenesis in sea urchin embryos using TALENs, DEVELOPMENT GROWTH & DIFFERENTIATION, 56(1), 92-97, 201401
    Link to Paper Search Results by DOI
  78. FAST-id system for enrichment of cells with TALEN-induced mutations and large deletions, GENES TO CELLS, 19(5), 419-431, 201405
    Link to Paper Search Results by DOI
  79. Germ Cell Mutations of the Ascidian Ciona intestinalis With TALE Nucleases, GENESIS, 52(5), 431-439, 201405
    Link to Paper Search Results by DOI
  80. ★, Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system, SCIENTIFIC REPORTS, 4, 20140623
    Link to Paper Search Results by DOI
  81. Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems, SCIENTIFIC REPORTS, 4, 20140716
    Link to Paper Search Results by DOI
  82. Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies, SCIENTIFIC REPORTS, 4, 20140827
    Link to Paper Search Results by DOI
  83. Application of Oocyte Cryopreservation Technology in TALEN-Mediated Mouse Genome Editing, EXPERIMENTAL ANIMALS, 63(3), 349-355, 201407
    Link to Paper Search Results by DOI
  84. EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step, JOURNAL OF CELL BIOLOGY, 206(3), 347-356, 20140804
    Link to Paper Search Results by DOI
  85. Simple knockout by electroporation of engineered endonucleases into intact rat embryos, SCIENTIFIC REPORTS, 4, 20141001
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  86. The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation, CELL REPORTS, 10(5), 664-673, 20150210
    Link to Paper Search Results by DOI
  87. Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9, STEM CELL REPORTS, 4(1), 143-154, 20150113
    Link to Paper Search Results by DOI
  88. ★, Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9, NATURE COMMUNICATIONS, 5, 201411
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  89. Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells, SCIENTIFIC REPORTS, 4, 20141120
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  90. Precise in-frame integration of exogenous DNA mediated by CRISPR/Cas9 system in zebrafish, SCIENTIFIC REPORTS, 5, 20150305
    Link to Paper Search Results by DOI
  91. Sterol Side Chain Reductase 2 Is a Key Enzyme in the Biosynthesis of Cholesterol, the Common Precursor of Toxic Steroidal Glycoalkaloids in Potato, PLANT CELL, 26(9), 3763-3774, 201409
    Link to Paper Search Results by DOI
  92. Targeted gene disruption by use of transcription activator-like effector nuclease (TALEN) in the water flea Daphnia pulex, BMC BIOTECHNOLOGY, 14, 20141118
    Link to Paper Search Results by DOI
  93. Tissue-specific and ubiquitous gene knockouts by TALEN electroporation provide new approaches to investigating gene function in Ciona, DEVELOPMENT, 141(2), 481-487, 20140115
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  94. A High Excision Potential of TALENs for Integrated DNA of HIV-Based Lentiviral Vector, PLOS ONE, 10(3), 20150317
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  95. Unliganded Thyroid Hormone Receptor alpha Regulates Developmental Timing via Gene Repression in Xenopus tropicalis, ENDOCRINOLOGY, 156(2), 735-744, 201502
    Link to Paper Search Results by DOI
  96. Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice, GENOME BIOLOGY, 16, 20150429
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  97. Production of knockout mice by DNA microinjection of various CRISPR/Cas9 vectors into freeze-thawed fertilized oocytes, BMC BIOTECHNOLOGY, 15, 20150522
    Link to Paper Search Results by DOI
  98. Tailor-made TALEN system for highly efficient targeted gene replacement in the rice blast fungus, BIOTECHNOLOGY AND BIOENGINEERING, 112(7), 1335-1342, 201507
    Link to Paper Search Results by DOI
  99. Generation of mutant mice via the CRISPR/Cas9 system using FokI-dCas9, SCIENTIFIC REPORTS, 5, 20150609
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  100. Hox10-regulated endodermal cell migration is essential for development of the ascidian intestine, DEVELOPMENTAL BIOLOGY, 403(1), 43-56, 20150701
    Link to Paper Search Results by DOI
  101. Smarcal1 promotes double-strand-break repair by nonhomologous end-joining, NUCLEIC ACIDS RESEARCH, 43(13), 6359-6372, 20150727
    Link to Paper Search Results by DOI
  102. Genome Editing in Mouse Spermatogonial Stem Cell Lines Using TALEN and Double-Nicking CRISPR/Cas9, STEM CELL REPORTS, 5(1), 75-82, 20150714
    Link to Paper Search Results by DOI
  103. Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells, CELL STEM CELL, 17(2), 178-194, 20150806
    Link to Paper Search Results by DOI
  104. Targeted gene correction of RUNX1 in induced pluripotent stem cells derived from familial platelet disorder with propensity to myeloid malignancy restores normal megakaryopoiesis, EXPERIMENTAL HEMATOLOGY, 43(10), 849-857, 201510
    Link to Paper Search Results by DOI
  105. Desmocollin-2 alone forms functional desmosomal plaques, with the plaque formation requiring the juxtamembrane region and plakophilins, JOURNAL OF BIOCHEMISTRY, 158(4), 339-353, 201510
    Link to Paper Search Results by DOI
  106. Homeolog-specific targeted mutagenesis in Xenopus laevis using TALENs, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 51(9), 879-884, 201510
    Link to Paper Search Results by DOI
  107. MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems, Nature Protocols, 11, 118-133, 2016
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  108. Homologous Recombination-Independent Large Gene Cassette Knock-in in CHO Cells Using TALEN and MMEJ-Directed Donor Plasmids, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 16(10), 23849-23866, 201510
    Link to Paper Search Results by DOI
  109. The Expression of TALEN before Fertilization Provides a Rapid Knock-Out Phenotype in Xenopus laevis Founder Embryos, PLOS ONE, 10(11), 20151118
    Link to Paper Search Results by DOI
  110. Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway, JOURNAL OF CELL BIOLOGY, 211(4), 775-784, 20151123
    Link to Paper Search Results by DOI
  111. Simultaneous live imaging of the transcription and nuclear position of specific genes, NUCLEIC ACIDS RESEARCH, 43(19), 20151030
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  112. Epithelial DLD-1 Cells with Disrupted E-cadherin Gene Retain the Ability to Form Cell Junctions and Apico-basal Polarity, CELL STRUCTURE AND FUNCTION, 40(2), 79-94, 2015
  113. Efficient modification of the myostatin gene in porcine somatic cells and generation of knockout piglets, MOLECULAR REPRODUCTION AND DEVELOPMENT, 83(1), 61-70, 201601
    Link to Paper Search Results by DOI
  114. Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines, GENES TO CELLS, 20(12), 1059-1076, 201512
    Link to Paper Search Results by DOI
  115. Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation, PLOS GENETICS, 12(1), 201601
    Link to Paper Search Results by DOI
  116. Depdc5 knockout rat: A novel model of mTORopathy, NEUROBIOLOGY OF DISEASE, 89, 180-189, 201605
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  117. Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells, STEM CELL REPORTS, 6(4), 496-510, 20160412
    Link to Paper Search Results by DOI
  118. In vivo tracking of histone H3 lysine 9 acetylation in Xenopus laevis during tail regeneration, GENES TO CELLS, 21(4), 358-369, 201604
    Link to Paper Search Results by DOI
  119. Report on the Conference on Transposition and Genome Engineering 2015 (TGE 2015): advancing cutting-edge genomics technology in the ancient city of Nara, GENES TO CELLS, 21(5), 392-395, 201605
    Link to Paper Search Results by DOI
  120. Temporal effects of Notch signaling and potential cooperation with multiple downstream effectors on adenohypophysis cell specification in zebrafish, GENES TO CELLS, 21(5), 492-504, 201605
    Link to Paper Search Results by DOI
  121. Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities, CELL REPORTS, 15(6), 1228-1241, 20160510
    Link to Paper Search Results by DOI
  122. Single-Cell-State Culture of Human Pluripotent Stem Cells Increases Transfection Efficiency, BIORESEARCH OPEN ACCESS, 5(1), 127-136, 201605
    Link to Paper Search Results by DOI
  123. Human Induced Pluripotent Stem Cell-Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 27(6), 1778-1791, 201606
    Link to Paper Search Results by DOI
  124. Establishment of Functional Genomics Pipeline in Epiblast-Like Tissue by Combining Transcriptomic Analysis and Gene Knockdown/Knockin/Knockout, Using RNA Interference and CRISPR/Cas9, HUMAN GENE THERAPY, 27(6), 436-450, 201606
    Link to Paper Search Results by DOI
  125. Cilia play a role in breaking left-right symmetry of the sea urchin embryo, GENES TO CELLS, 21(6), 568-578, 201606
    Link to Paper Search Results by DOI
  126. Rapid and efficient analysis of gene function using CRISPR-Cas9 in Xenopus tropicalis founders, GENES TO CELLS, 21(7), 755-771, 201607
    Link to Paper Search Results by DOI
  127. Involvement of aspartoacylase in tremor expression in rats, EXPERIMENTAL ANIMALS, 65(3), 293-301, 201607
  128. Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing, CELL STEM CELL, 19(1), 127-138, 20160707
  129. Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single-amino-acid-substituted, and floxed mice, BIOLOGY OPEN, 5(8), 1142-1148, 20160815
    Link to Paper Search Results by DOI
  130. Highly multiplexed CRISPR-Cas9-nuclease and Cas9-nickase vectors for inactivation of hepatitis B virus, GENES TO CELLS, 21(11), 1253-1262, 201611
    Link to Paper Search Results by DOI
  131. Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ, BMC GENOMICS, 17, 20161128
    Link to Paper Search Results by DOI
  132. Non-RVD mutations that enhance the dynamics of the TAL repeat array along the superhelical axis improve TALEN genome editing efficacy, SCIENTIFIC REPORTS, 6, 20161124
    Link to Paper Search Results by DOI
  133. Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa, MATRIX BIOLOGY, 56, 132-149, 201612
    Link to Paper Search Results by DOI
  134. Transcriptional regulation of a horizontally transferred gene from bacterium to chordate, PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 283(1845), 20161228
    Link to Paper Search Results by DOI
  135. C-Type Lectin Receptor DCAR Recognizes Mycobacterial Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during Infection, IMMUNITY, 45(6), 1245-1257, 20161220
    Link to Paper Search Results by DOI
  136. Quadruple zebrafish mutant reveals different roles of Mesp genes in somite segmentation between mouse and zebrafish, DEVELOPMENT, 143(15), 2842-2852, 201608
    Link to Paper Search Results by DOI
  137. Detailed analysis of targeted gene mutations caused by the Platinum-Fungal TALENs in Aspergillus oryzae RIB40 strain and a ligD disruptant, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 123(3), 287-293, 201703
    Link to Paper Search Results by DOI
  138. Germ cell regeneration-mediated, enhanced mutagenesis in the ascidian Ciona intestinalis reveals flexible germ cell formation from different somatic cells, DEVELOPMENTAL BIOLOGY, 423(2), 111-125, 20170315
    Link to Paper Search Results by DOI
  139. Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice, BIOLOGY OPEN, 6(5), 706-713, 20170515
    Link to Paper Search Results by DOI
  140. Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system, NUCLEIC ACIDS RESEARCH, 45(9), 5198-5207, 20170519
    Link to Paper Search Results by DOI
  141. Hox-mediated endodermal identity patterns pharyngeal muscle formation in the chordate pharynx, DEVELOPMENT, 144(9), 1629-1634, 20170501
    Link to Paper Search Results by DOI
  142. Participation of androgen and its receptor in sex determination of an amphibian species, PLOS ONE, 12(6), 20170605
    Link to Paper Search Results by DOI
  143. Cas9, Cpf1 and C2c1/2/3-What's next?, BIOENGINEERED, 8(3), 265-273, 2017
    Link to Paper Search Results by DOI
  144. Establishment of expanded and streamlined pipeline of PITCh knock-in - a web-based design tool for MMEJ-mediated gene knock-in, PITCh designer, and the variations of PITCh, PITCh-TG and PITCh-KIKO, BIOENGINEERED, 8(3), 302-308, 2017
    Link to Paper Search Results by DOI
  145. PAX2 is dispensable for in vitro nephron formation from human induced pluripotent stem cells, SCIENTIFIC REPORTS, 7, 20170703
    Link to Paper Search Results by DOI
  146. Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells, SCIENTIFIC REPORTS, 7, 20170720
    Link to Paper Search Results by DOI
  147. Developmental changes in drug-metabolizing enzyme expression during metamorphosis of Xenopus tropicalis, JOURNAL OF TOXICOLOGICAL SCIENCES, 42(5), 605-613, 201710
  148. Establishment of pten knockout medaka with transcription activator-like effector nucleases (TALENs) as a model of PTEN deficiency disease, PLOS ONE, 12(10), 20171020
    Link to Paper Search Results by DOI
  149. PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation, HUMAN MOLECULAR GENETICS, 26(22), 4429-4440, 20171115
    Link to Paper Search Results by DOI
  150. Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology, SCIENTIFIC REPORTS, 7, 20171109
    Link to Paper Search Results by DOI
  151. ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair, PLOS ONE, 12(11), 20171117
    Link to Paper Search Results by DOI
  152. TALEN-mediated targeted editing of the GDE5 gene suppresses fibroblastic cell proliferation, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 81(11), 2164-2167, 2017
    Link to Paper Search Results by DOI
  153. Dynamic changes in the interchromosomal interaction of early histone gene loci during development of sea urchin, JOURNAL OF CELL SCIENCE, 130(24), 4097-4107, 201712
    Link to Paper Search Results by DOI
  154. Tailor-made gene silencing of Staphylococcus aureus clinical isolates by CRISPR interference, PLOS ONE, 13(1), 20180129
    Link to Paper Search Results by DOI
  155. Functional analysis of thyroid hormone receptor beta in Xenopus tropicalis founders using CRISPR-Cas, BIOLOGY OPEN, 7(1), 201801
    Link to Paper Search Results by DOI
  156. Cancer induction and suppression with transcriptional control and epigenome editing technologies, JOURNAL OF HUMAN GENETICS, 63(2), 187-194, 201802
    Link to Paper Search Results by DOI
  157. Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes, SCIENTIFIC REPORTS, 8, 20180216
    Link to Paper Search Results by DOI
  158. Microhomology-assisted scarless genome editing in human iPSCs, NATURE COMMUNICATIONS, 9, 20180305
    Link to Paper Search Results by DOI
  159. Replication stress induces accumulation of FANCD2 at central region of large fragile genes, NUCLEIC ACIDS RESEARCH, 46(6), 2932-2944, 20180406
    Link to Paper Search Results by DOI
  160. Unexpected heterogeneity derived from Cas9 ribonucleoprotein-introduced clonal cells at the HPRT1 locus, GENES TO CELLS, 23(4), 255-263, 201804
    Link to Paper Search Results by DOI
  161. HpBase: A genome database of a sea urchin, Hemicentrotus pulcherrimus, DEVELOPMENT GROWTH & DIFFERENTIATION, 60(3), 174-182, 201804
    Link to Paper Search Results by DOI
  162. Clustered Xenopus keratin genes: A genomic, transcriptomic, and proteomic analysis, DEVELOPMENTAL BIOLOGY, 426(2), 384-392, 20170615
    Link to Paper Search Results by DOI
  163. Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology, JOURNAL OF RADIATION RESEARCH, 59, 201804
    Link to Paper Search Results by DOI
  164. Targeted knock-in of an scFv-Fc antibody gene into the hprt locus of Chinese hamster ovary cells using CRISPR/Cas9 and CRIS-PITCh systems, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 125(5), 599-605, 201805
    Link to Paper Search Results by DOI
  165. Identification of a cell-penetrating peptide applicable to a protein-based transcription activator-like effector expression system for cell engineering, BIOMATERIALS, 173, 11-21, 201808
    Link to Paper Search Results by DOI
  166. Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms, ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 59(6), 529-538, 201807
    Link to Paper Search Results by DOI
  167. ★, Biased genome editing using the local accumulation of DSB repair molecules system, NATURE COMMUNICATIONS, 9, 20180816
    Link to Paper Search Results by DOI
  168. Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes, STEM CELL REPORTS, 11(3), 727-740, 20180911
    Link to Paper Search Results by DOI
  169. Generation of and characterization of anti-IL-11 antibodies using newly established Il11-deficient mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 505(2), 453-459, 20181028
    Link to Paper Search Results by DOI
  170. MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(10), 201810
    Link to Paper Search Results by DOI
  171. Cas9 ribonucleoprotein complex allows direct and rapid analysis of coding and noncoding regions of target genes in Pleurodeles waltl development and regeneration, DEVELOPMENTAL BIOLOGY, 443(2), 127-136, 20181115
    Link to Paper Search Results by DOI
  172. Acceleration of cancer science with genome editing and related technologies, CANCER SCIENCE, 109(12), 3679-3685, 201812
    Link to Paper Search Results by DOI
  173. Three-Component Repurposed Technology for Enhanced Expression: Highly Accumulable Transcriptional Activators via Branched Tag Arrays, CRISPR JOURNAL, 1(5), 337-347, 201810
    Link to Paper Search Results by DOI
  174. Nucleotide receptor P2RY4 is required for head formation via induction and maintenance of head organizer in Xenopus laevis, DEVELOPMENT GROWTH & DIFFERENTIATION, 61(2), 186-197, 201902
    Link to Paper Search Results by DOI
  175. Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(8), 3072-3081, 20190219
    Link to Paper Search Results by DOI
  176. Loss of HCN1 subunits causes absence epilepsy in rats, BRAIN RESEARCH, 1706, 209-217, 20190301
    Link to Paper Search Results by DOI
  177. PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching, PLOS ONE, 14(3), 20190306
    Link to Paper Search Results by DOI
  178. Electroporation-mediated genome editing in vitrified/warmed mouse zygotes created by IVF via ultra-superovulation, EXPERIMENTAL ANIMALS, 67(4), 535-543, 201812
    Link to Paper Search Results by DOI
  179. Elucidation of secondary alcohol metabolism in Starmerella bombicola and contribution of primary alcohol oxidase FAO1, FEMS YEAST RESEARCH, 19(2), 201903
    Link to Paper Search Results by DOI
  180. PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer, CELL DEATH DISCOVERY, 4, 20180208
    Link to Paper Search Results by DOI
  181. KLF1 mutation E325K induces cell cycle arrest in erythroid cells differentiated from congenital dyserythropoietic anemia patient-specific induced pluripotent stem cells, EXPERIMENTAL HEMATOLOGY, 73, 25-37, 201905
    Link to Paper Search Results by DOI
  182. Anephrogenic phenotype induced by SALL1 gene knockout in pigs, SCIENTIFIC REPORTS, 9, 20190529
    Link to Paper Search Results by DOI
  183. Increased seizure sensitivity, emotional defects and cognitive impairment in PHD finger protein 24 (Phf24)-null rats, BEHAVIOURAL BRAIN RESEARCH, 369, 20190902
    Link to Paper Search Results by DOI
  184. Single-Molecule Nanoscopy Elucidates RNA Polymerase II Transcription at Single Genes in Live Cells, CELL, 178(2), 491-+, 20190711
    Link to Paper Search Results by DOI
  185. Activin Is Superior to BMP7 for Efficient Maintenance of Human iPSC-Derived Nephron Progenitors, STEM CELL REPORTS, 13(2), 322-337, 20190813
    Link to Paper Search Results by DOI
  186. Establishment of knockout adult sea urchins by using a CRISPR-Cas9 system, DEVELOPMENT GROWTH & DIFFERENTIATION, 61(6), 378-388, 201908
    Link to Paper Search Results by DOI
  187. Targeted mutagenesis of the ryanodine receptor by Platinum TALENs causes slow swimming behaviour in Pacific bluefin tuna (Thunnus orientalis), SCIENTIFIC REPORTS, 9, 20190925
    Link to Paper Search Results by DOI
  188. Role of dynamic nuclear deformation on genomic architecture reorganization, PLOS COMPUTATIONAL BIOLOGY, 15(9), 201909
    Link to Paper Search Results by DOI
  189. Efficient genome engineering using Platinum TALEN in potato, PLANT BIOTECHNOLOGY, 36(3), 167-173, 201909
    Link to Paper Search Results by DOI
  190. CRISPR-Cas3 induces broad and unidirectional genome editing in human cells, NATURE COMMUNICATIONS, 10, 20191206
    Link to Paper Search Results by DOI
  191. TAp63 represses transcription of MYCN/NCYM gene and its high levels of expression are associated with favorable outcome in neuroblastoma, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 518(2), 311-318, 20191015
    Link to Paper Search Results by DOI
  192. Pathological characteristics of Ccdc85c knockout rats: a rat model of genetic hydrocephalus, EXPERIMENTAL ANIMALS, 69(1), 26-33, 202001
    Link to Paper Search Results by DOI
  193. Hox13 is essential for formation of a sensory organ at the terminal end of the sperm duct in Ciona, DEVELOPMENTAL BIOLOGY, 458(1), 120-131, 20200201
    Link to Paper Search Results by DOI
  194. EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD, ELIFE, 9, 20200217
    Link to Paper Search Results by DOI
  195. GABA-Induced GnRH Release Triggers Chordate Metamorphosis, CURRENT BIOLOGY, 30(8), 1555-+, 20200420
    Link to Paper Search Results by DOI
  196. Various strategies of effector accumulation to improve the efficiency of genome editing and derivative methodologies, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 56(5), 359-366, 202005
    Link to Paper Search Results by DOI
  197. Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells, SCIENCE ADVANCES, 6(25), 202006
    Link to Paper Search Results by DOI
  198. Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome, EMBO JOURNAL, 39(12), 20200617
  199. A simple and practical workflow for genotyping of CRISPR-Cas9-based knockout phenotypes using multiplexed amplicon sequencing, GENES TO CELLS, 25(7), 498-509, 202007
    Link to Paper Search Results by DOI
  200. Reinvestigation of Disulfide-bonded Oligomeric Forms of the Unfolded Protein Response Transducer ATF6, CELL STRUCTURE AND FUNCTION, 45(1), 9-21, 2020
    Link to Paper Search Results by DOI
  201. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk, TRANSLATIONAL PSYCHIATRY, 10(1), 20200722
    Link to Paper Search Results by DOI
  202. Six1is required for signaling center formation and labial-lingual asymmetry in developing lower incisors, DEVELOPMENTAL DYNAMICS, 249(9), 1098-1116, 202009
    Link to Paper Search Results by DOI
  203. DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondria, SCIENTIFIC REPORTS, 10(1), 20200309
    Link to Paper Search Results by DOI
  204. Three multi-allelic gene pairs are responsible for self-sterility in the ascidian Ciona intestinalis, SCIENTIFIC REPORTS, 10(1), 20200213
    Link to Paper Search Results by DOI
  205. Efficient and multiplexable genome editing using Platinum TALENs in oleaginous microalga,Nannochloropsis oceanicaNIES-2145, GENES TO CELLS, 25(10), 695-702, 202010
    Link to Paper Search Results by DOI
  206. Regenerating islet-derived protein (Reg)3 beta plays a crucial role in attenuation of ileitis and colitis in mice, BIOCHEMISTRY AND BIOPHYSICS REPORTS, 21, 202003
    Link to Paper Search Results by DOI
  207. Single-gene imaging links genome topology, promoter-enhancer communication and transcription control, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 27(11), 1032-+, 202011
    Link to Paper Search Results by DOI
  208. Amiodarone bioconcentration and suppression of metamorphosis in Xenopus, AQUATIC TOXICOLOGY, 228, 202011
    Link to Paper Search Results by DOI
  209. Development of a protein-based system for transient epigenetic repression of immune checkpoint molecule and enhancement of antitumour activity of natural killer cells, BRITISH JOURNAL OF CANCER, 122(6), 823-834, 20200317
    Link to Paper Search Results by DOI
  210. TALEN-mediated generation of Nkx3.1 knockout rat model, PROSTATE, 81(3), 182-193, 202102
    Link to Paper Search Results by DOI
  211. PHF24 is expressed in the inhibitory interneurons in rats, EXPERIMENTAL ANIMALS, 70(1), 137-143, 2021
    Link to Paper Search Results by DOI
  212. Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation, NATURE METABOLISM, 3(2), 196-+, 202102
    Link to Paper Search Results by DOI
  213. CRISPR-Cas9 editing of non-coding genomic loci as a means of controlling gene expression in the sea urchin, DEVELOPMENTAL BIOLOGY, 472, 85-97, 202104
    Link to Paper Search Results by DOI
  214. Improvement of fatty acid productivity of thraustochytrid, Aurantiochytrium sp. by genome editing, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 131(4), 373-380, 202104
    Link to Paper Search Results by DOI
  215. Pou5f3.3 is involved in establishment and maintenance of hematopoietic cells during Xenopus development, TISSUE & CELL, 72, 202110
    Link to Paper Search Results by DOI
  216. NBS1 I171V variant underlies individual differences in chromosomal radiosensitivity within human populations, SCIENTIFIC REPORTS, 11(1), 20211004
    Link to Paper Search Results by DOI
  217. TALEN-Mediated Gene Editing of slc24a5 (Solute Carrier Family 24, Member 5) in Kawakawa, Euthynnus affinis, JOURNAL OF MARINE SCIENCE AND ENGINEERING, 9(12), 202112
    Link to Paper Search Results by DOI
  218. Characterization of DNA methylation and promoter activity of long terminal repeat elements of feline endogenous retrovirus RDRS C2a, VIRUS GENES, 58(1), 70-74, 202202
    Link to Paper Search Results by DOI

Publications such as books

  1. 2013, 標的遺伝子の改変を可能にする人工ヌクレアーゼの開発、化学工業, 2013, Scholarly Book, Joint work
  2. 2012/07, 人工ヌクレアーゼを用いたゲノム編集, 2012, 07, Scholarly Book, Joint work
  3. 2006/04, DNA Structure, Chromatin and Gene ExpressionChapter 14, "Involvement of nuclear matrix and chromatin loop formation in the function of insulators.", 2006, 04, Scholarly Book, Cocompilation, 8178952289
  4. 2006/04, Involvement of nuclear matrix and chromatin loop formation in the function of insulators (DNA structure, chromatin and gene expression) , 2006, 04, Scholarly Book, Cocompilation, 8178952289, 252
  5. 2001, Initiation of meiosis in organ culture of newt testes by IGF-I , Perspective in Comparative Endocrinolog, 2001, Report
  6. 1998, 両生類の発生生物学 , 1998, Scholarly Book
  7. 1988/08, 両生類における精子分化機構. 「生殖細胞の発生と性分化」, 1988, 08, Scholarly Book, Cocompilation
  8. 1997, Proliferation of newt spermatogonia in vitro and expression of activin β subunit genes by Sertoli Cells. , J. Reprod. Dev., 1997, Report
  9. 1996, Expression of activin beta subunit and type II receptor genes during newt spermatogenesis. , Inhibin= Activin and Follistatin, 1996, Report

Invited Lecture, Oral Presentation, Poster Presentation

  1. Applications of genome editing technology for various aspects of life science research, Yamamoto T, 2019/09, With Invitation, English
  2. Genome editing research and education in Hiroshima University, 2019/01/09, Without Invitation, Japanese
  3. Genome editing in cultured cells and animals, Academic Workshop by Hiroshima University and Cairo University, 2017/03, With Invitation, English

Awards

  1. 2016/11/14, Blue Flame Award, (NPO) Addgene
  2. 2013/09/11, JB Award, 公益社団法人日本生化学会会長, Nucleosome exclusion from the interspecies conserved central AT-rich region of the Ars insulator.
  3. 1999/09, Zoological Science Award, The Zoological Society of Japan, Cloning and expression of a cDNA encoding a prolactin receptor of the Japanese red-bellied newt, Cynops pyrrhogaster

Works, etc.

  1. ・ノーベル賞最有力候補「ゲノム編集」が本命とは言えない理由, 2020
  2. ・ゲノム編集ってなに？⑤ゲノム編集技術の課題, 2016
  3. ・ゲノム編集, 2016
  4. ・ゲノム編集ってなに？④品種改良での利用, 2015
  5. ・ゲノム編集ってなに？③医学分野での利用, 2015
  6. ・ゲノム編集ってなに？②遺伝子組み換えとの違い, 2015
  7. ・ゲノム編集ってなに？①仕組み, 2015
  8. ・新春展望2015「ゲノム編集技術の開発と応用は新しいステージへ」, 2015
  9. ・新春展望2014「ゲノム編集からエピゲノム編集へ」, 2014
  10. ・「数理生命科学ディレクター養成プログラム」取組報告書, 2007/04

External Funds

Acceptance Results of Competitive Funds

  1. 2022, 2032
  2. 2020, 2024
  3. 2020, 2022
  4. 2014, 2018
  5. 2014, 2018
  6. Practical Research Project for Rare / Intractable Diseases, 2015/11/16, 2016/03/31
  7. KAKENHI, 2014, 2016
    Permalink
  8. 2015
  9. 2014, 2017
  10. Health and Labour Sciences Research Grants, 2014/06/02, 2015/03/31
  11. 2013, 2015
  12. 2013
  13. 2012
  14. 2011
  15. 2008/04, 2009/03
  16. KAKENHI, Quantitative analysis of cell-cell interaction responsible for the robustness of development, 2009, 2011
    Permalink
  17. KAKENHI, Gene expression noise during cell differentiation and its regulation, 2008, 2010
    Permalink
  18. KAKENHI, 2008, 2009
    Permalink
  19. KAKENHI, Studies on the gene network responsible for the specific gene expression during development, 2005, 2007
    Permalink
  20. 2005
  21. KAKENHI, 2004, 2005
    Permalink
  22. KAKENHI, 2002, 2003
    Permalink
  23. KAKENHI, Switching Mechanism for Meiosis Initiation or Apoptosis in Spermatogonia, 2000, 2001
    Permalink
  24. KAKENHI, 2000, 2001
    Permalink
  25. 2000
  26. KAKENHI, 1998, 1999
    Permalink
  27. KAKENHI, Mechanism of apoptosis induction in amphibian spermatogonia by prolactin, 1997, 1999
    Permalink
  28. KAKENHI, 1996, 1996
    Permalink
  29. KAKENHI, 1995, 1995
    Permalink
  30. KAKENHI, 1995, 1995
    Permalink
  31. KAKENHI, Analysis of the mechanism underlying meiosis initiation using in vitro culture system., 1993, 1995
    Permalink
  32. KAKENHI, 2013, 2016
    Permalink
  33. KAKENHI, 2013, 2015
    Permalink

Social Activities

Organizing Academic Conferences, etc.

  1. 2021/03
  2. 2021/11
  3. 2018/02
  4. 2015/11, 2015/11
  5. 2014/10
  6. International Symposium on RNAi and Genome Editing Methods, 2014/03, 2014/03
  7. 2013/10
  8. 2012/10
  9. 2012/02
  10. 2011/, 2014/
  11. 2011/
  12. 2006/06
  13. 1998/05

History as Peer Reviews of Academic Papers

  1. 2020, Gene and Genome Editing, Chief editor, Executive Editor
  2. 2016, Nature Communications