KAZUHIRO TAGUCHI

Last Updated :2026/01/07

Affiliations, Positions
Hiroshima University Hospital, Assistant Professor
Self-introduction
I have worked as a gastrointestinal surgeon and a cancer immunologist, engaging in both clinical practice and research. I believe that overcoming cancer, a disease that continues to claim many lives, is a fundamental mission and a profound responsibility of physicians and researchers to society. Guided by this conviction, I am committed to pursuing research that consistently reflects this belief in the years ahead.

Basic Information

Major Professional Backgrounds

  • 2025/04, Hiroshima University Hospital, Department of Gastroenterological and Transplant Surgery, Assistant Professor
  • 2020/10, Massachusetts General Hospital/Harvard Medical School, Center for Immunology and Inflammatory Diseases, Post-doc Research Fellow
  • 2020/04, Hiroshima University Hospital, Department of Gastroenterological and Transplant Surgery, Medical Doctor
  • 2015/04, National Hospital Organization Kure Medical Center/Chugoku Cancer Center, Institute of Clinical Research/Department of Clinical Laboratory, Medical Doctor
  • 2014/04, Hiroshima University Hospital, Department of Gastroenterological and Transplant Surgery, Medical Doctor
  • 2013/04, Hiroshima City Hiroshima Citizens Hospital, Surgery, Medical Doctor
  • 2012/04, National Hospital Organization Higashihiroshima Medical Center, Surgery, Senior Resident
  • 2010/04, JA ONOMICHI GENERAL HOSPITAL, Surgery, Senior Resident
  • 2008/04, JA ONOMICHI GENERAL HOSPITAL, Clinical Resident

Educational Backgrounds

  • Hiroshima University, Graduate School of Biomedical & Health Sciences , Japan, 2015/04, 2020/02
  • Hiroshima University, School of Medicine, Japan, 2002/04, 2008/03

Educational Activity

  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Digestive surgery

Research Keywords

  • Surgery, Gastrointestinal oncology, Cancer immunology, Tumor microenvironment, Cancer immunotherapy, Colorectal cancer, Liver cancer, Colorectal surgery, Chemotherapy, Radiation therapy, Endoscopic surgery, Treg, Endothelial cells, T cells, NK cells

Affiliated Academic Societies

  • The Japan Society for Transplantation
  • American Association for Cancer Research
  • Japan Surgical Association
  • Japanese Association of Cancer Immunology
  • The Japan Cancer Association
  • Japan Society for Endoscopic Surgery
  • The Japanese Society of Gastroenterology
  • The japan Society of Coloproctology
  • The Japanese Society of Gastroenterological Surgery
  • Japan Surgical Society

Research Activities

Academic Papers

  1. Perioperative and Oncological Outcomes of Colorectal Cancer Surgery in Obese Patients: A Multicenter Retrospective Study, Annals of Gastroenterological Surgery, 20251219
  2. ★, The aged tumor microenvironment limits T cell control of cancer, Nature Immunology, 202406
  3. Prediction of anastomotic leakage after left-sided colorectal cancer surgery: a pilot study utilizing quantitative near-infrared spectroscopy, Surgery Today, 52(6), 971-977, 20220111
  4. The characteristics of residual pneumoperitoneum after laparoscopic colorectal surgery, Asian Journal of Endoscopic Surgery, 15(2), 320-327, 20211108
  5. Tumor budding as a predictive marker for 5-fluorouracil response in adjuvant-treated stage III colorectal cancer, International Journal of Clinical Oncology, 26(7), 2021
  6. The prognostic value of organ/space surgical site infection in stage I colorectal cancer recurrence, International Journal of Colorectal Disease, 35(9), 2020
  7. ★, Tumor endothelial cell-mediated antigen-specific t-cell suppression via the PD-1/PD-L1 pathway, Molecular Cancer Research, 18(9), 2020
  8. Preoperative incremental maximum squeeze pressure as a predictor of fecal incontinence after very low anterior resection for low rectal cancer, Surgery Today, 50(5), 2020
  9. Postoperative Portal Hypertension Enhances Alloimmune Responses after Living-Donor Liver Transplantation in Patients and in a Mouse Model, The Journal of Immunology, 203(5), 20190901
  10. Isolation of tumor endothelial cells from murine cancer, Journal of Immunological Methods, 464, 201901
  11. Is laparoscopic colorectal surgery with continuation of antiplatelet therapy safe without increasing bleeding complications?, Surgery Today, 49(11), 2019
  12. Simultaneous liver-kidney transplantation in patient with a history of heparin-induced thrombocytopenia: A case report and literature review, American Journal of Case Reports, 20, 2019
  13. Surgical techniques for advanced transverse colon cancer using the pincer approach of the transverse mesocolon, Surgical Endoscopy, 33(2), 2019
  14. A case of ascending colon cancer accompanied with tumor thrombosis in the superior mesenteric vein treated with right hemicolectomy and greater saphenous vein grafting, International Journal of Surgery Case Reports, 51, 2018
  15. Effect of bevacizumab plus XELOX (CapeOX) chemotherapy on liver natural killer cell activity in colorectal cancer with resectable liver metastasis, Annals of Gastroenterological Surgery, 2(5), 2018
  16. A case of intrahepatic cholangiocarcinoma with peritoneal dissemination treated successfully with surgical resection and adjuvant chemotherapy, Japanese Journal of Cancer and Chemotherapy, 41(12), 2014

Invited Lecture, Oral Presentation, Poster Presentation

  1. Exploring the mechanisms of Treg reprogramming in the tumor microenvironment, Taguchi K, Broad Immunology Program Meeting, 2024/06/25, With Invitation, English, Broad Institute, Boston, MA
  2. Exploring the mechanisms of Treg reprogramming in the tumor microenvironment, Taguchi K, Arthur and Sandra Irving, Cancer Immunology Innovation Retreat, 2024/01/22, Without Invitation, English, Boston, MA
  3. Exploring the mechanisms of Treg reprogramming in the tumor microenvironment, Taguchi K, 2023/11/07, Without Invitation, English, Boston, MA
  4. Exploring the mechanisms of Treg reprogramming in the tumor microenvironment, Taguchi K, Arthur and Sandra Irving, Cancer Immunology Innovation Retreat, 2023/01/24, Without Invitation, English, Lincoln, NH
  5. Exploring the mechanisms of Treg reprogramming in the tumor microenvironment, Taguchi K, CIID Floor Meeting, 2021/10/26, Without Invitation, English, Boston, MA
  6. Novel mechanism underlying tumor immune-evasion across tumor endothelial cells, Taguchi K, The 10th Kure International Medical Forum, 2017, With Invitation, English, Kure, Hiroshima, Japan
  7. Novel mechanism underlying tumor immune-evasion across tumor endothelial cells, Taguchi K, The 29th Rajavithi Hospital Annual Academic Meeting, 2018, With Invitation, English, Bangkok, Thailand

Awards

  1. 2023/06, Cheiron-GIFTS 2023 First Place, Cheiron Initiative
  2. 2022/04, JSPS Overseas Research Fellowships, Japan Society for the Promotion of Science
  3. 2021/04, Research Fellowship, The Uehara Memorial Foundation
  4. 2020/04, JSGE Support for Young Gastroenterologists Studying in the United States, The Japanese Society of Gastroenterology
  5. 2016/08, 26th International Congress of the Transplantation Society, International Transplantation Science Mentee / Mentor Awards (Mentee), The Transplantation Society

External Funds

Acceptance Results of Competitive Funds

  1. SGH Cancer Research Grant, 2025/12, 2027/12
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  2. 2025/07/31, 2027/03/31
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Social Activities

History as Peer Reviews of Academic Papers

  1. Medical science monitor, Reviewer
  2. The American journal of case reports, Reviewer
  3. Surgery Today, Reviewer
  4. Cancer Science, Reviewer
  5. Annals of Transplantation, Reviewer