TAKAYUKI NAKAGAWA

Last Updated :2025/03/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
E-mail
tnakagahiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2009/04/01, 2009/11/30, Hiroshima University Hospital, hospital, Clinical Fellow
  • 2009/12/01, 2017/03/31, Hiroshima University, hospital, Assistant Professor
  • 2007/04/01, 2007/09, Tokyo Medical and Dental University, clinical Fellow
  • 2007/10/01, 2008/03, Chiba Cancer Center, clinical Fellow
  • 2008/04/01, 2009/03, Tokyo Medical and Dental University, clinical Fellow
  • 2017/04, 2019/06, Tokushima University, Assistant Professor
  • 2019/07/01, 2019/08/31, Hiroshima University, Hospital, Clinical Fellow
  • 2019/09/01, 2022/05/31, Hiroshima University, Hospital, Assistant Professor

Educational Backgrounds

  • Tokyo Medical and Dental University, Japan, 2003/04, 2007/03
  • The University of Tokushima, School of Dentistry , Japan, 1997/04, 2003/03

Academic Degrees

  • Doctor of Philosophy in Dental Science, Tokyo Medical and Dental University

In Charge of Primary Major Programs

  • Dentistry

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Surgical dentistry

Research Keywords

  • oral cancer
  • Medication Related Osteonecrosis of Jaw

Affiliated Academic Societies

  • Japan Society for Head and Neck Cancer
  • The Japanese Society of Oral and Maxillofacial Surgeons
  • Japanese Cancer Association
  • The Japanese Society for Jaw Deformity
  • Japanese Society of Oral and Maxillofacial Trauma
  • Japanese Academy of Maxillofacial Implants

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 1Term, Oral and Maxillofacial Surgery I
  2. 2024, Undergraduate Education, 2Term, Oral and Maxillofacial Surgery II
  3. 2024, Undergraduate Education, First Semester, Dental Research Practices I
  4. 2024, Undergraduate Education, 3Term, Basic Practice of Oral and Maxillofacial Medicine III
  5. 2024, Undergraduate Education, 4Term, Basic Practice of Oral and Maxillofacial Medicine IV
  6. 2024, Undergraduate Education, 3Term, Clinical Anatomy for Dentistry I
  7. 2024, Undergraduate Education, 4Term, Clinical Anatomy for Dentistry II
  8. 2024, Undergraduate Education, 3Term, Practice of Clinical Anatomy for Dentistry I
  9. 2024, Undergraduate Education, 4Term, Practice of Clinical Anatomy for Dentistry II
  10. 2024, Undergraduate Education, Second Semester, Dental Research Practices II
  11. 2024, Undergraduate Education, 2Term, Advanced Course in Applied Oral Biology and Medicine
  12. 2024, Undergraduate Education, 2Term, Advanced Course in Oral and Maxillofacial Medicine
  13. 2024, Undergraduate Education, First Semester, Dental Research Practices III
  14. 2024, Undergraduate Education, Academic Year, Clinical Practice (Oral Surgery II)

Research Activities

Academic Papers

  1. ACE2 expression and spike S1 protein-mediated immune responses in oral mucosal cells., Oral diseases, 30(4), 2293-2305, 202405
  2. Surgical Orthodontic Treatment for Skeletal Maxillary Protrusion in Sturge-Weber Syndrome: A Case Report and Review of the Literature., Cureus, 16(5), e59964, 202405
  3. Inhibition of angiogenesis and tumor progression of MK-0429, an integrin alpha v beta(3) antagonist, on oral squamous cell carcinoma, JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 148(12), 3281-3292, 2022
  4. Zoledronate Inhibits Osteoclast Differentiation via Suppressing Vascular Endothelial Growth Factor Receptor 2 Expression., Biochemical genetics, 58(3), 473-489, 2020
  5. ★, Zoledronate inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclast differentiation via suppression of expression of nuclear factor of activated T-cell cl and carbonic anhydrase 2, ARCHIVES OF ORAL BIOLOGY, 60(4), 557-565, 201504
    Link to Paper Search Results by DOI
  6. ★, Application of low-crystalline carbonate apatite granules in 2-stage sinus floor augmentation: a prospective clinical trial and histomorphometric evaluation, Journal of periodontal & implant science, 49(6), 382-396
    Link to Paper Search Results by DOI
  7. Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma., Cancer Science, 97, 1070-1074
  8. Chemical inhibition of LSD1 leads to epithelial to mesenchymal transition in vitro of an oral squamous cell carcinoma OM-1 cell line via release from LSD1-dependent suppression of ZEB1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 647, 23-29, 20230305
    Link to Paper Search Results by DOI
  9. Expression of anti-fungal peptide, beta-defensin 118 in oral fibroblasts induced by C. albicans beta-glucan-containing particles, JOURNAL OF APPLIED ORAL SCIENCE, 30, 2022
    Link to Paper Search Results by DOI
  10. Immune response to cytosolic DNA via intercellular receptor modulation in oral keratinocytes and fibroblasts, ORAL DISEASES, 28(1), 150-163, 202011
    Link to Paper Search Results by DOI
  11. In vitro investigation of the cell compatibility and antibacterial properties of titanium treated with calcium and ozone, DENTAL MATERIALS JOURNAL, 40(3), 712-718, 202106
    Link to Paper Search Results by DOI
  12. Morphological Evaluation of Bone by CT to Determine Primary Stability-Clinical Study, MATERIALS, 13(11), 202006
    Link to Paper Search Results by DOI
  13. TNF-alpha-induced IL-6 and MMP-9 expression in immortalized ameloblastoma cell line established by hTERT, ORAL DISEASES, 23(2), 199-209, 201703
    Link to Paper Search Results by DOI
  14. Aesthetic recovery of alveolar atrophy following autogenous onlay bone grafting using interconnected porous hydroxyapatite ceramics (IP-CHA) and resorbable poly-L-lactic/polyglycolic acid screws: case report, BMC ORAL HEALTH, 14, 20140602
    Link to Paper Search Results by DOI
  15. 3-dimensional composite scaffolds consisting of apatite-PLGA-atelocollagen for bone tissue engineering, DENTAL MATERIALS JOURNAL, 31(3), 465-471, 201205
    Link to Paper Search Results by DOI
  16. Preoperative oral health care reduces postoperative inflammation and complications in oral cancer patients, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 12(3), 1922-1928, 201609
    Link to Paper Search Results by DOI
  17. PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation., Oncogene, 26, 7921-7932
  18. The protocadherins, PCDHB1 and PCDH7, areregulated by MeCP2 in neuronal cells and braintissues: implication for pathogenesis of Rett syndrome., BMC neurosci., 12, 81

Invited Lecture, Oral Presentation, Poster Presentation

  1. Inhibition of angiogenesis and tumor progression of MK-0429, an integrin alpha-v-beta 3 antagonist, on oral squamous cell carcinoma, Nakagawa T, Ohta K, Naruse T, Sakuma M, Okuda S, Fukada S, Yamakado N, Akagi M, Sasaki K, Niwata C, Ono S, Aikawa T., 2022/11/04, Without Invitation, English
  2. Evaluation of Anti-tumor effect of MK-0429, an integrin αvβ3 inhibitor, by inhibiting angiogenesis, Nakagawa T, Ohta K, Naruse T, Narisawa S, Sakuma M, Yamakado N, Okuda S, Mizuta K, Ninomiya Y, Ono S, Takechi M., The 80th Annual Meeting of the Japanese Cancer Association, 2021/10/02, Without Invitation, English
  3. A case of osteochondroma of the unilateral mandibular condyle with severe occlusal deviation., 2021/05/13, Without Invitation, Japanese
  4. A case of coronoidectomy using surgical guide for trismus caused by bilateral coronoid hyperplasia, MISATO TADA, SHIGEHIRO ONO, KUNIKO MIZUTA, TAKAYUKI NAKAGAWA, RYO UETSUKI and MASAAKI TAKECHI, 2021/06/12, Without Invitation, Japanese
  5. The effects of surgical orthodontic treatment on BMI in jaw deformity patients, RYO UETSUKI, SHIGEHIRO ONO, KUNIKO MIZUTA, TAKAYUKI NAKAGAWA, MISATO TADA, KAZUKI SASAKI and MASAAKI TAKECHI, 2021/06/11, Without Invitation, Japanese
  6. Evaluation of anti-tumor effect of anti- integrin agent, MK-0429., 2020/11/13, Without Invitation, Japanese
  7. Zoledronate inhibits RANKL-induced osteoclast differentiation via suppression of expression of NFATc1 and carbonic anhydrase 2, Takayuki Nakagawa, Kohji Ohta, Kazumi Kubozono, Yoko Ishida, Masaaki Takechi, The Annual Meeting of American Association of Oral and Maxillofacial Surgeons 2014 In Conjunction with the Japanese Society and Korean Association of Oral and Maxillofacial Surgeons, 2014/09/08, Without Invitation, English, American Association of Oral & Maxillofacial Surgeons, Honolulu, HI, USA
  8. Clinical study of the bone augmentation using the interconnected porous calcium hydroxyapatite for dental implant treatment., Nakagawa T, Ohta K, Ninomiya Y, Tada M, Ishida F, Ono S, Takechi M., The 45th Annual Meeting of the Japanese Society of Oral Implantology (Sep 21st 2015 Okayama), 2015/09/21, Without Invitation, Japanese
  9. A late relapse case of tongue cancer with therapy-related myelodysplastic syndrome after interstitial brachytherapy, Nakagawa T, Ohta K, Ninomiya Y, Uetsuki R, Takechi M, The 60th congress of the Japanese Society of Oral and Maxillofacial Surgeons, 2015/10/16, Without Invitation, Japanese, Nagoya
  10. Two-jaw osteotomy for treatment of a patient with facial asymmetry caused by unilateral condylar hyperplasia., Nakagawa T, Ono S, Kaku M, Kojima S, Sumi H, Uetsuki R, Tanimoto K, Takechi M., The 25th Annual Meeting of the Japanese Society for Jaw Deformity, 2015/06/04, Without Invitation, Japanese, the Japanese Society for Jaw Deformity, Tokyo

External Funds

Acceptance Results of Competitive Funds

  1. 2024, 2027
  2. 2021, 2023
  3. 2021, 2023
  4. Research Grant of Harmonic Ito Foundation 2020, Evaluation of anti-tumor effect of anti- integrin agent, MK-0429., 2020, 2021
  5. KAKENHI, 2015, 2017
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  6. KAKENHI, 2013, 2014
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  7. KAKENHI, 2013, 2015
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  8. KAKENHI, Development of the high functional GBR membrane with osteoconduction and resorption by osteoclast, 2011, 2013
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  9. KAKENHI, Genome-wide screening of target genes of BRONJ, 2011, 2012
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  10. KAKENHI, 2010, 2014
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  11. KAKENHI, Development of the very functional biomaterial that possess theability of the control of the drug delivery system., 2010, 2012
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  12. KAKENHI, 2018, 2020
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  13. KAKENHI, 2018, 2020
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  14. KAKENHI, 2018, 2020
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  15. KAKENHI, 2018, 2020
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