Last Updated :2023/02/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor or Lecturer
Web Site
Other Contact Details
1-2-3, Kasumi, Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5162 FAX : (+81)82-257-5164
I belong to Department of Epidemiology, Infectious Disease Control and Prevention, Institute of Biomedical and Health Sciences Hiroshima University. My former study theme was mathematical statistics, however, I started on the job training of epidemiological research in medical field. Now, research themes in our laboratory are epidemiology of viral hepatitis, promotion of blood donation and others, form two different approach: "dry" and "wet". My research is mainly proceeded from the view of "dry" study.

Basic Information

Academic Degrees

  • Doctor of Science, Hiroshima University
  • Master of Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Public Health
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Society medicine;Epidemiology and preventive medicine

Research Keywords

  • Medical Statistics
  • Mathematical epidemiology

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Intensive, Social Medicine
  2. 2022, Undergraduate Education, 2Term, Outline of the Global Leadership Role
  3. 2022, Graduate Education (Master's Program) , 1Term, Seminar on Health Policy & Global Health
  4. 2022, Graduate Education (Master's Program) , 2Term, Basic Biostatistics and Basic Clinical Statistics
  5. 2022, Graduate Education (Master's Program) , First Semester, Basic Epidemiology and Practice
  6. 2022, Graduate Education (Master's Program) , Second Semester, Basic and Advanced Training on Methodology for Clinical Research
  7. 2022, Graduate Education (Master's Program) , First Semester, Exercise and Seminar on Epidemiological Research and It's Analysis
  8. 2022, Graduate Education (Master's Program) , 3Term, Exercises and Seminar on Medical Statistics Using Statistical Software
  9. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Epidemiology,Infectious Disease Control and Prevention
  10. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Epidemiology,Infectious Disease Control and Prevention
  11. 2022, Graduate Education (Doctoral Program) , Second Semester, Basic and Advanced Training on Methodology for Clinical Research

Research Activities

Academic Papers

  1. An improvement method of sliced inverse regression using principal component analysis., Journal of Statistics and Application., 4(2-3), 489-498, 2009
  2. ★, High-dimensional Edgeworth expansion of a test statistic on independence and its error bound., Journal of Multivariate Analysis, 101, 1806-1813, 2010
  3. Estimation on inverse regression using principal components of covariance matrix of sliced data, HIROSHIMA MATHEMATICAL JOURNAL, 41(1), 41-53, 201103
  4. Total Numbers of Undiagnosed Carriers of Hepatitis C and B Viruses in Japan Estimated by Age- and Area-Specific Prevalence on the National Scale, INTERVIROLOGY, 54(4), 185-195, 2011
  5. Prognosis of chronic spontaneous urticaria in 117 patients not controlled by a standard dose of antihistamine, ALLERGY, 68(2), 229-235, 201302
  6. The Applicability of Ganglion Cell Complex Parameters Determined From SD-OCT Images to Detect Glaucomatous Eyes, JOURNAL OF GLAUCOMA, 22(9), 713-718, 201312
  7. Evaluation of strategies for control and prevention of pandemic influenza (H1N1pdm) in Japanese children attending school in a rural town Simulation using mathematical models, Jpn J Public Health, 60(4), 204-211, 20130415
  8. Width of abnormal ganglion cell complex area determined using optical coherence tomography to predict glaucoma, JAPANESE JOURNAL OF OPHTHALMOLOGY, 58(1), 47-55, 201401
  9. Inner retinal layer comparisons of eyes with exudative age-related macular degeneration and eyes with age-related macular degeneration and glaucoma, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 252(4), 563-570, 201404
  10. ★, Validation and limitation of age-period-cohort model in simulating mortality due to hepatocellular carcinoma from 1940 to 2010 in Japan, HEPATOLOGY RESEARCH, 44(7), 713-719, 201407
  11. Using the Early Postoperative Intraocular Pressure to Predict Pressure Control After a Trabeculectomy, JOURNAL OF GLAUCOMA, 23(6), 410-414, 201408
  12. Estimating numbers of persons with persistent hepatitis B virus infection transmitted vertically and horizontally in the birth cohort during 1950-1985 in Japan, HEPATOLOGY RESEARCH, 44(10), E181-E188, 201410
  13. High prevalences of hepatitis B and C virus infections among adults living in Binh Thuan province, Vietnam, HEPATOLOGY RESEARCH, 45(3), 259-268, 201503
  14. Seroprevalence, genotypic distribution and potential risk factors of hepatitis B and C virus infections among adults in Siem Reap, Cambodia, HEPATOLOGY RESEARCH, 45(4), 480-487, 201504
  15. Hepatitis E Virus in Cambodia: Prevalence among the General Population and Complete Genome Sequence of Genotype 4, PLOS ONE, 10(8), 20150828
  16. Hepatitis B virus infection in hemodialysis patients in Japan: Prevalence, incidence and occult hepatitis B virus infection, HEPATOLOGY RESEARCH, 45(12), 1211-1219, 201512
  17. Estimated numbers of patients with liver disease related to hepatitis B or C virus infection based on the database reconstructed from medical claims from 2008 to 2010 in Japan, HEPATOLOGY RESEARCH, 45(12), 1228-1240, 201512
  18. The association of hepatitis C virus infection with the prognosis of chronic hemodialysis patients: A retrospective study of 3,064 patients between 1999 and 2010, JOURNAL OF MEDICAL VIROLOGY, 87(9), 1558-1564, 2015
  19. Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones, JOURNAL OF INFECTION, 72(1), 91-102, 201601
  20. Different sensitivity of rituximab-treatment to B-cells between ABO-incompatible kidney and liver transplantation, HUMAN IMMUNOLOGY, 77(6), 456-463, 201606
  21. Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation, BRITISH JOURNAL OF PHARMACOLOGY, 173(15), 2434-2445, 201608
  22. Reproducibility of optic disk evaluation in supine subjects with a Heidelberg Retina Tomograph II laser tomographic scanner, CLINICAL OPHTHALMOLOGY, 10, 1617-1622, 2016
  23. ★, Predicting future blood supply and demand in Japan with a Markov model: application to the sex- and age-specific probability of blood donation, TRANSFUSION, 56(11), 2750-2759, 201611
  24. High Vaccination Coverage among Children during Influenza A(H1N1)pdm09 as a Potential Factor of Herd Immunity, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 13(10), 201610
  25. Study of the issues of receiving hepatitis screening and the rate of consulting hospitals-The rate of recognized receiving hepatitis screening and that of the unrecognized-, Kanzo, 57(12), 634-648, 2016
  26. Systematic review and meta-analysis of hepatitis C virus infection in the Democratic Republic of Congo., Public health, 139, 2016
  27. Mustard gas exposure and mortality among retired workers at a poisonous gas factory in Japan: a 57-year follow-up cohort study, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 74(5), 321-327, 201705
  28. Reduced prevalence of hepatitis B surface antigen positivity among pregnant women born after the national implementation of immunoprophylaxis for babies born to hepatitis B virus-carrier mothers in Japan, HEPATOLOGY RESEARCH, 47(12), 1329-1334, 201711
  29. Differences in the impact of prognostic factors for hepatocellular carcinoma over time, CANCER SCIENCE, 108(12), 2438-2444, 201712
  30. A comparison of clinicopathological features and prognosis in prostate cancer between atomic bomb survivors and control patients., Oncology letters, 14(1), 2017
  31. Progression of Liver Fibrosis Is Associated With Non-Liver-Related Mortality in Patients With Nonalcoholic Fatty Liver Disease, HEPATOLOGY COMMUNICATIONS, 1(9), 899-910, 201711
  32. A seroepidemiological survey of the effect of hepatitis B vaccine and hepatitis B and C virus infections among elementary school students in Siem Reap province, Cambodia, HEPATOLOGY RESEARCH, 48(3), E172-E182, 201802
  33. Pilot study for hepatitis virus screening among employees as an effective approach to encourage employees who screened positive to receive medical care in Japan, HEPATOLOGY RESEARCH, 48(3), E291-E302, 201802
  34. Hepatitis B virus core-related antigen levels predict progression to liver cirrhosis in hepatitis B carriers, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 33(4), 918-925, 201804
  35. Efficacy of cognitive-behavioral therapy for patients with temporomandibular disorder pain-systematic review of previous reports, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 11(2), 500-509, 2018
  36. Trends in the total numbers of HBV and HCV carriers in Japan from 2000 to 2011, JOURNAL OF VIRAL HEPATITIS, 25(4), 363-372, 201804
  37. High prevalence of hepatitis B infections in Burkina Faso (1996-2017): a systematic review with meta-analysis of epidemiological studies, BMC PUBLIC HEALTH, 18, 20180425
  38. Cost-effectiveness analyses of anti-hepatitis C virus treatments using quality of life scoring among patients with chronic liver disease in Hiroshima prefecture, Japan, HEPATOLOGY RESEARCH, 48(7), 509-520, 201806
  39. Impact of previously cured hepatocellular carcinoma (HCC) on new development of HCC after eradication of hepatitis C infection with non-interferon-based treatments, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 48(6), 664-670, 201809
  40. Natural course of persistent hepatitis B virus infection in hepatitis B e antigen-positive and hepatitis B e antigen-negative cohorts in Japan based on the Markov model, JOURNAL OF MEDICAL VIROLOGY, 90(12), 1800-1813, 201812
  41. Long-term natural history of liver disease in patients with chronic hepatitis B virus infection: an analysis using the Markov chain model, JOURNAL OF GASTROENTEROLOGY, 53(11), 1196-1205, 201811
  42. Impact of hepatocellular carcinoma aetiology and liver function on the benefit of surveillance: A novel approach for the adjustment of lead-time bias, LIVER INTERNATIONAL, 38(12), 2260-2268, 201812
  43. Incidence rates of hepatitis C virus infection among blood donors in Japan: a nationwide retrospective cohort study, TRANSFUSION, 58(12), 2880-2885, 201812
  44. New Diagnostic Criteria for the Localization of Insulinomas with the Selective Arterial Calcium Injection Test: Decision Tree Analysis, JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 29(12), 1749-1753, 201812
  45. Acquisition rate of antibody to hepatitis B surface antigen among medical and dental students in Japan after three-dose hepatitis B vaccination, VACCINE, 37(1), 145-151, 20190103
  46. The impact of HCV eradication by direct-acting antivirals on the transition of precancerous hepatic nodules to HCC: A prospective observational study, LIVER INTERNATIONAL, 39(3), 448-454, 201903
  47. Analysis of the anatomical features of pulmonary veins on pre-procedural cardiac CT images resulting in incomplete cryoballoon ablation for atrial fibrillation, JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, 13(2), 118-127, 2019
  48. Natural history of liver-related disease in patients with chronic hepatitis C virus infection: An analysis using a Markov chain model, JOURNAL OF MEDICAL VIROLOGY, 91(10), 1837-1844, 201910
  49. Countermeasures against viral hepatitis B and C in Japan: An epidemiological point of view, HEPATOLOGY RESEARCH, 49(9), 990-1002, 201909
  50. Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients with hepatocellular carcinoma, SCIENTIFIC REPORTS, 9, 20191031
  51. The emergence of non-hypervascular hypointense nodules on enhanced MRI in patients with chronic hepatitis C, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 50(11-12), 1232-1238, 201912
  52. Comparison of new prognostic systems for patients with resectable hepatocellular carcinoma: Albumin-Bilirubin grade and Albumin-Indocyanine Green Evaluation grade, HEPATOLOGY RESEARCH, 49(10), 1218-1226, 201910
  53. Long-term prognosis of liver disease in patients with chronic hepatitis B virus infection receiving nucleos(t)ide analogue therapy: an analysis using a Markov chain model, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 31(11), 1452-1459, 201911
  54. Hepatitis B surface antigen seroprevalence among pre- and post-vaccine cohorts in Cambodia, 2017, VACCINE, 37(35), 5059-5066, 20190814
  55. Liver stiffness does not affect ultrasound-guided attenuation coefficient measurement in the evaluation of hepatic steatosis, HEPATOLOGY RESEARCH, 50(2), 190-198, 202002
  56. The changing epidemiology of hepatitis B and C infections in Nanoro, rural Burkina Faso: a random sampling survey, BMC INFECTIOUS DISEASES, 20(1), 20200115
  57. Biological Effects of Low-Dose Chest CT on Chromosomal DNA, RADIOLOGY, 295(2), 439-445, 202005
  58. Existence of hepatitis B virus surface protein mutations and other variants: demand for hepatitis B infection control in Cambodia, BMC INFECTIOUS DISEASES, 20(1), 20200425
  59. Diagnostic performance of peripheral leukocyte telomere G-tail length for detecting breast cancer, CANCER SCIENCE, 111(5), 1856-1861, 202005
  60. Predicting the presence of breast cancer using circulating small RNAs, including those in the extracellular vesicles, CANCER SCIENCE, 111(6), 2104-2115, 202006
  61. The Tokyo subway sarin attack has long-term effects on survivors: A 10-year study started 5 years after the terrorist incident, PLOS ONE, 15(6), 20200623
  62. Long-term prognosis of liver disease in patients with eradicated chronic hepatitis C virus: An analysis using a Markov chain model, HEPATOLOGY RESEARCH, 50(8), 936-946, 202008
  63. ★, Meta-regression Analysis of Sex- and Birth Year-Specific Prevalence of HBsAg and Anti-HCV Among Un-diagnosed Japanese: Data From the First-time Blood Donors, Periodical Health Checkup, and the Comprehensive Health Checkup With Lifestyle Education (Ningen Dock), JOURNAL OF EPIDEMIOLOGY, 30(9), 420-425, 202009
  64. Evaluation of the efficiency of dried blood spot-based measurement of hepatitis B and hepatitis C virus seromarkers, SCIENTIFIC REPORTS, 10(1), 20200302
  65. Liver Resection for Multiple Hepatocellular Carcinomas A Japanese Nationwide Survey, ANNALS OF SURGERY, 272(1), 145-154, 202007
  66. Eighteen-year follow-up cohort study on hepatitis B and C virus infections related long-term prognosis among hemodialysis patients in Hiroshima, JOURNAL OF MEDICAL VIROLOGY, 92(12), 3436-3447, 202012
  67. Demonstration of Human Fetal Bone Morphology with MR Imaging: A Preliminary Study, MAGNETIC RESONANCE IN MEDICAL SCIENCES, 19(4), 310-317, 2020
  68. PNPLA3andHLA-DQB1polymorphisms are associated with hepatocellular carcinoma after hepatitis C virus eradication, JOURNAL OF GASTROENTEROLOGY, 55(12), 1162-1170, 202012
  69. Comparison of liver disease state progression in patients with eradication of versus persistent infection with hepatitis C virus: Markov chain analysis, JOURNAL OF VIRAL HEPATITIS, 28(3), 538-547, 202103
  70. A novel model for predicting posthepatectomy liver failure based on liver function and degree of liver resection in patients with hepatocellular carcinoma, HPB, 23(1), 134-143, 202101
  71. Molecular characterization and the mutation pattern of SARS-CoV-2 during first and second wave outbreaks in Hiroshima, Japan, PLOS ONE, 16(2), 20210205
  72. Evaluating Individual Radiosensitivity for the Prediction of Acute Toxicities of Chemoradiotherapy in Esophageal Cancer Patients, RADIATION RESEARCH, 195(3), 244-252, 202103
  73. Screening for M-proteinemia consisting of monoclonal gammopathy of undetermined significance and multiple myeloma for 30 years among atomic bomb survivors in Hiroshima, INTERNATIONAL JOURNAL OF HEMATOLOGY, 113(4), 576-585, 202104
  74. Prevalence of total hepatitis A antibody among 5 to 7 years old children and their mothers in Cambodia, SCIENTIFIC REPORTS, 11(1), 20210226
  75. A multi-institutional survey of the quality of life after treatment for uterine cervical cancer: a comparison between radical radiotherapy and surgery in Japan, JOURNAL OF RADIATION RESEARCH, 62(2), 269-284, 202103
  76. Impact of Immune Reconstitution-Induced Hepatic Flare on Hepatitis B Surface Antigen Loss in Hepatitis B Virus/Human Immunodeficiency Virus-1 Coinfected Patients, JOURNAL OF INFECTIOUS DISEASES, 223(12), 2080-2089, 20210615
  77. Epidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis, BMC INFECTIOUS DISEASES, 21(1), 20211101
  78. Relationship between drinking frequency and fatty liver prevalence or incidence in Japanese undergoing health checkup in 2008-2019, LIVER INTERNATIONAL, 41(12), 2914-2923, 202112
  79. Effect of COVID-19 on hepatitis B and C virus countermeasures: Hepatologist responses from nationwide survey in Japan, HEPATOLOGY RESEARCH, 52(11), 899-907, 202211
  80. Prevalence of fatty liver and advanced fibrosis by ultrasonography and FibroScan in a general population random sample, HEPATOLOGY RESEARCH, 52(11), 908-918, 202211
  81. Seroepidemiological study of factors affecting anti-spike IgG antibody titers after a two-dose mRNA COVID-19 vaccination in 3744 healthy Japanese volunteers, SCIENTIFIC REPORTS, 12(1), 20220929
  82. A longitudinal study of anti-SARS-CoV-2 antibody seroprevalence in a random sample of the general population in Hiroshima in 2020, ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 27, 2022
  83. ★, Impact of robot-assisted surgery appearance on reduction of annual blood transfusion cases in Japan: application of meta-analysis and NDB open data, JOURNAL OF ROBOTIC SURGERY, 16(5), 1229-1232, 202210
  84. Prevalence of Helicobacter pylori infection in the general population evaluated by a resident-register-based epidemiological study, JOURNAL OF GASTROENTEROLOGY, 57(8), 540-546, 202208
  86. Impact of antiviral therapy for disease progression and non-invasive liver fibrosis index in patients with chronic hepatitis C: Markov chain model analysis, HEPATOLOGY RESEARCH, 52(8), 665-676, 202208
  87. ★, Burden of chronic hepatitis B and C infections in 2015 and future trends in Japan: A simulation study, LANCET REGIONAL HEALTH-WESTERN PACIFIC, 22, 202205
  88. Adverse reactions to the BNT162b2 and mRNA-1273 mRNA COVID-19 vaccines in Japan, JOURNAL OF INFECTION AND CHEMOTHERAPY, 28(4), 576-581, 202204
  89. Postoperative oral energy and protein intakes for an enhanced recovery after surgery program incorporating early enteral nutrition for pancreaticoduodenectomy: A retrospective study, NUTRITION IN CLINICAL PRACTICE, 37(3), 654-665, 202206
  90. Long COVID occurrence in COVID-19 survivors, SCIENTIFIC REPORTS, 12(1), 20220411
  91. Prevalence and genotype distribution of viral hepatitis B in Cambodia between 1990 and 2020: a systematic review and meta-analysis, ARCHIVES OF PUBLIC HEALTH, 80(1), 20220413
  92. Exercising the Sanger Sequencing Strategy for Variants Screening and Full-Length Genome of SARS-CoV-2 Virus during Alpha, Delta, and Omicron Outbreaks in Hiroshima, VIRUSES-BASEL, 14(4), 202204
  93. Distribution of FIB-4 index in the general population: analysis of 75,666 residents who underwent health checkups, BMC GASTROENTEROLOGY, 22(1), 20220513
  94. The preventive effects of perioperative oral care on surgical site infections after pancreatic cancer surgery: a retrospective study, SUPPORTIVE CARE IN CANCER, 30(4), 3337-3344, 202204
  95. Mass Screening of SARS-CoV-2 Variants using Sanger Sequencing Strategy in Hiroshima, Japan, SCIENTIFIC REPORTS, 12(1), 20220214
  96. Effects of Hand Hygiene Using 4% Chlorhexidine Gluconate or Natural Soap During Hand Rubbing Followed by Alcohol-Based 1% Chlorhexidine Gluconate Sanitizer Lotion in the Operating Room, ADVANCES IN WOUND CARE, 11(1), 1-9, 20220101

Invited Lecture, Oral Presentation, Poster Presentation

  1. Evaluation of cancer screening using lead time bias adjusting survival rate increase and its application to HCC surveillance, Akita T, Ohisa M, Kumada T and Tanaka J, Population-based Time-to-event Analyses International Conference (PTA 2016), 2016/08/31, Without Invitation, English, London, UK
  2. SMR distribution of HCC in Japan, 1970-2010, Tomoyuki Akita, Masayuki Ohisa, Mami Yamashita, Chikako Yamamoto, Shintaro Nagashima, Hiroaki Nobuhara, Yoshihiko Miura, Junko Tanaka, The 12th JSH Single Topic Conference, 2016/09/22, Without Invitation, Japanese
  3. Epidemiological analysis of the mortality due to hepatocellular carcinoma, Akita T, Tanaka J, MIRAI seminar 2019, 2019/11/12, With Invitation, English, Stockholm

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, Mathematical and epidemiological analysis and prediction of mortality due to hepatocellular carcinoma, 2011, 2012
  2. KAKENHI, 2016, 2017
  3. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2018, 2020
  4. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2022, 2024

Social Activities

History as Peer Reviews of Academic Papers

  1. 2015, Environmental Health and Preventive Medicine, Others, reviewer, 1
  2. 2017, Environmental Health and Preventive Medicine, Others, 2
  3. 2020, Liver International, Others, 4
  4. 2020, Hepatology Research, Others, 2
  5. 2021, Liver International, Others, 4
  6. 2021, Hepatology Research, Others, 1