Hirofumi Maruyama

Last Updated :2025/06/10

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
E-mail
hmaruhiroshima-u.ac.jp
Other Contact Details
1-2-3, Kasumi, Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5201 FAX : (+81)82-505-0490
Self-introduction
I study neurodegenerative disease.

Basic Information

Major Professional Backgrounds

  • 2007/04/01, 2013/03/31, Hiroshima University, Research Institute for Radiation Biology and Medicine, Associate Professor
  • 2013/04/01, 2017/01/31, Hiroshima University, Institute of Biomedical & Health Sciences, Associate Professor
  • 2017/02/01, 2019/03/31, Hiroshima University, Clinical Neuroscience and Therapeutics, Professor
  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1992/04, 1996/03
  • Hiroshima University, Faculty of Medicine, Japan, 1984/04, 1990/03

Academic Degrees

  • M.D., Ph.D., Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Neurology

Research Keywords

  • neurodegeneration
  • Dementia, Alzheimer's disease
  • amyotrophic lateral sclerosis
  • Spinocerebellar ataxia
  • gene, risk factor
  • genetic counseling

Affiliated Academic Societies

  • Japanese Society of Internal Medicine, 1990
  • Japanese Society of Neurology, 1992
  • Japan Geriatrics Society, 1992
  • Japan Society of Human Genetics, 2001
  • The Japan Stroke Society, 2002
  • American Society of Human Genetics, 2010
  • Japan Society for Dementia Research, 2012
  • World Stroke Organization, 2014
  • World Federation of Neurology, 2011

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, First Semester, Human genetics
  2. 2025, Undergraduate Education, Intensive, Medical Neuroscience II
  3. 2025, Undergraduate Education, Year, Medical Neuroscience III
  4. 2025, Undergraduate Education, Intensive, Practice for medical research
  5. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  6. 2025, Undergraduate Education, Intensive, Practice of Medicine II
  7. 2025, Graduate Education (Master's Program) , Second Semester, General Clinical Medicine and Dentistry
  8. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Clinical Neuroscience and Therapeutics
  9. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Clinical Neuroscience and Therapeutics
  10. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Clinical Neuroscience and Therapeutics
  11. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Clinical Neuroscience and Therapeutics
  12. 2025, Graduate Education (Master's Program) , First Semester, Basic Human Genetics Practice

Research Activities

Academic Papers

  1. Intravenous Thrombolysis for Pediatric Ischemic Stroke Secondary to Cancer Therapy-related Cardiac Dysfunction, INTERNAL MEDICINE, 64(2), 287-291, 2025
    Link to Paper Search Results by DOI
  2. Relationships between dysarthria, lesion location, and oral/swallowing function in patients with first-ever stroke, CLINICAL NEUROLOGY AND NEUROSURGERY, 254, 108929, 202507
    Link to Paper Search Results by DOI
  3. Intracellular anionic substances cause tau liquid-liquid phase separation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 757, 151605, 20250409
    Link to Paper Search Results by DOI
  4. Early initiation of intravenous cyclophosphamide and one-year outcome in super-refractory cryptogenic-new onset refractory status epilepticus, EPILEPSIA OPEN, 10(1), 307-313, 202502
    Link to Paper Search Results by DOI
  5. Screening of toxic-metabolic encephalopathy with and without epileptic seizure with density spectral array, JOURNAL OF THE NEUROLOGICAL SCIENCES, 472, 123462, 20250515
    Link to Paper Search Results by DOI
  6. Investigation of the improvement of swallowing function with low-frequency pulse waves or interference waves delivered via cervical electrical stimulation in patients with Parkinson's disease: A randomized controlled study protocol, CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS, 44, 101463, 202504
    Link to Paper Search Results by DOI
  7. Alpha-band activity in density spectral array predictive for neurological outcome in patients with hypoxic-ischemic encephalopathy, CLINICAL NEUROLOGY AND NEUROSURGERY, 250, 108791, 202503
    Link to Paper Search Results by DOI
  8. Presenteeism in people with previous and current epilepsy: Determinants and psychosocial associations, SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 125, 16-22, 202502
    Link to Paper Search Results by DOI
  9. Pitfalls of the E-Ref Procedure: Tie Values and the Proportion of the Abnormal Data, MUSCLE & NERVE, 71(3), 435-441, 202503
    Link to Paper Search Results by DOI
  10. Fusobacterium nucleatum in the oral cavity is associated with cerebral small vessel disease in patients with ischemic stroke, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 34(1), 108183, 202501
    Link to Paper Search Results by DOI
  11. Long-term changes in carotid intima-media thickness according to baseline blood pressure level: J-STARS Echo study, JOURNAL OF THE NEUROLOGICAL SCIENCES, 468, 123342, 20250115
    Link to Paper Search Results by DOI
  12. Time-course assessment of oral intake function and its impact on end-of-life in older individuals over 90 years with frailty, GERIATRICS & GERONTOLOGY INTERNATIONAL, 25(1), 96-101, 202501
    Link to Paper Search Results by DOI
  13. A single-center, single-arm, prospective, open-label, and comparative trial to evaluate the safety and tolerability profile of a 90-day oral L-arginine hydrochloride intervention for patients with amyotrophic lateral sclerosis, SCIENTIFIC REPORTS, 15(1), 1120, 20250107
    Link to Paper Search Results by DOI
  14. Myelin measurement in amyotrophic lateral sclerosis with synthetic MRI: A potential diagnostic and predictive method, JOURNAL OF THE NEUROLOGICAL SCIENCES, 468, 123337, 20250115
    Link to Paper Search Results by DOI
  15. Oral condition at admission predicts functional outcomes and hospital-acquired pneumonia development among acute ischemic stroke patients, CLINICAL ORAL INVESTIGATIONS, 28(8), 434, 20240719
    Link to Paper Search Results by DOI
  16. Interictal head-turning sign in patients with idiopathic generalized epilepsy during initial medical interview: A matched multicenter study, EPILEPSY & BEHAVIOR, 160, 110039, 202411
    Link to Paper Search Results by DOI
  17. Protocol for a phase 2 study of bosutinib for amyotrophic lateral sclerosis using real-world data: induced pluripotent stem cell-based drug repurposing for amyotrophic lateral sclerosis medicine (iDReAM) study, BMJ OPEN, 14(10), e082142, 20241022
    Link to Paper Search Results by DOI
  18. High-density surface electromyography evaluation of the suprahyoid muscles in patients with Parkinson's disease, JOURNAL OF THE NEUROLOGICAL SCIENCES, 466, 123266, 20241115
    Link to Paper Search Results by DOI
  19. Transcutaneous auricular vagus nerve stimulation enhances short-latency afferent inhibition via central cholinergic system activation, SCIENTIFIC REPORTS, 14(1), 11224, 20240516
    Link to Paper Search Results by DOI
  20. Worsening of myasthenic symptoms associated with statins, JOURNAL OF THE NEUROLOGICAL SCIENCES, 464, 123145, 20240915
    Link to Paper Search Results by DOI
  21. Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging, JOURNAL OF NEUROVIROLOGY, 30(2), 197-201, 202404
    Link to Paper Search Results by DOI
  22. Vagus nerve size determined via ultrasonography is associated with white matter lesions in patients with vascular risk factors, JOURNAL OF ULTRASOUND, 27(3), 723-732, 202409
    Link to Paper Search Results by DOI
  23. Clinical manifestations and outcomes associated with a high 2HELPS2B score in patients with acute impaired consciousness, JOURNAL OF THE NEUROLOGICAL SCIENCES, 465, 123174, 20241015
    Link to Paper Search Results by DOI
  24. Analysis of the suprahyoid muscles during tongue elevation: High-density surface electromyography as a novel tool for swallowing-related muscle assessment, JOURNAL OF ORAL REHABILITATION, 51(9), 1872-1880, 202409
    Link to Paper Search Results by DOI
  25. Redefined giant somatosensory evoked potentials: Evoked epileptic complexes of excitatory and inhibitory components, CLINICAL NEUROPHYSIOLOGY, 164, 119-129, 202408
    Link to Paper Search Results by DOI
  26. Detection of episodic nocturnal hypercapnia in patients with neurodegenerative disorders, SLEEP AND BREATHING, 28(1), 393-399, 202403
    Link to Paper Search Results by DOI
  27. Emergency medical service response for cases of stroke-suspected seizure: A population-based study, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 33(6), 107681, 202406
    Link to Paper Search Results by DOI
  28. Cervical percutaneous interferential current stimulation improves citric acid cough tests in patients with Parkinson's disease on medication, SCIENTIFIC REPORTS, 14(1), 11386, 20240518
    Link to Paper Search Results by DOI
  29. Clinical and Pathological Features of FTDP-17 with MAPT p.K298_H299insQ Mutation, MOVEMENT DISORDERS CLINICAL PRACTICE, 11(6), 720-727, 202406
    Link to Paper Search Results by DOI
  30. Irregular Tremulous Movements and Infrequent Seizures: A Clinical-Electrophysiological Diagnosis of Benign Adult Familial Myoclonus Epilepsy, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(3), e56303, 20240317
    Link to Paper Search Results by DOI
  31. Chronic Visual Abnormality in an Elderly Patient With Temporal Lobe Epilepsy, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(3), e56696, 20240322
    Link to Paper Search Results by DOI
  32. Association between motor symptoms of Parkinson's disease and swallowing disorders, NEUROLOGICAL SCIENCES, 45(5), 2021-2026, 202405
    Link to Paper Search Results by DOI
  33. An Early Neurological Indicator of Immune Effector Cell-Associated Neurotoxicity Syndrome, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(3), e57298, 20240330
    Link to Paper Search Results by DOI
  34. Diffusion-Weighted Imaging Hyperintensities in Acute and Subacute-Phase Intracerebral Hemorrhage, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 31(8), 106549, 202208
    Link to Paper Search Results by DOI
  35. Short-term or long-term outcomes for stroke patients with cancer according to biological markers, JOURNAL OF THE NEUROLOGICAL SCIENCES, 436, 120246, 20220515
    Link to Paper Search Results by DOI
  36. Impact of the RNF213 p.R4810K Variant on Endovascular Therapy for Large-Vessel Occlusion Stroke, STROKE-VASCULAR AND INTERVENTIONAL NEUROLOGY, 2(6), e000396, 202211
    Link to Paper Search Results by DOI
  37. Diagnostic value of lower extremity ultrasonographic nerve enlargement for differentiating demyelinating Charcot-Marie-Tooth disease from chronic inflammatory demyelinating polyneuropathy, JOURNAL OF THE NEUROLOGICAL SCIENCES, 460, 122995, 20240515
    Link to Paper Search Results by DOI
  38. Prospective Observational Study for the Comparison of Screening Methods Including Tongue Pressure and Repetitive Saliva Swallowing With Detailed Videofluoroscopic Swallowing Study Findings in Patients With Acute Stroke, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 13(3), e032852, 20240206
    Link to Paper Search Results by DOI
  39. Therapeutic Time Window With DWI-ADC (Diffusion-Weighted Imaging-Apparent Diffusion Coefficient) Match and Periodic Discharges for Status Epilepticus, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(2), e53811, 20240207
    Link to Paper Search Results by DOI
  40. Density spectrum array and difficult to diagnose seizure activity, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 116(11), 947-948, 202311
    Link to Paper Search Results by DOI
  41. On-scene time delays for epileptic seizures in developed community-based integrated care system regions, EPILEPSY & BEHAVIOR, 151, 109612, 202402
    Link to Paper Search Results by DOI
  42. Liver fibrosis index is associated with functional outcome among acute ischemic stroke patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 33(2), 107537, 202402
    Link to Paper Search Results by DOI
  43. The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's disease, SCIENTIFIC REPORTS, 14(1), 227, 20240102
    Link to Paper Search Results by DOI
  44. Apolipoprotein E genotype-dependent accumulation of amyloid beta in APP-knock-in mouse model of Alzheimer's disease, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 683, 149106, 20231126
    Link to Paper Search Results by DOI
  45. Peak expiratory flow, but not tongue pressure, can predict pneumonia development in older adults, EUROPEAN GERIATRIC MEDICINE, 14(1), 211-217, 202302
    Link to Paper Search Results by DOI
  46. Attacks With Urinary Incontinence Without Convulsions: Complete Atrioventricular Block Mimicking an Epileptic Seizure, CUREUS JOURNAL OF MEDICAL SCIENCE, 15(11), e49552, 20231128
    Link to Paper Search Results by DOI
  47. Detailed findings of videofluoroscopic examination among patients with Parkinson's disease on the effect of cervical percutaneous interferential current stimulation, FRONTIERS IN NEUROLOGY, 14, 1212024, 20231107
    Link to Paper Search Results by DOI
  48. Swallowing sound index analysis using electronic stethoscope and artificial intelligence for patients with Parkinson's disease, JOURNAL OF THE NEUROLOGICAL SCIENCES, 454, 120831, 20231115
    Link to Paper Search Results by DOI
  49. 'Raisin bread sign' feature of pontine autosomal dominant microangiopathy and leukoencephalopathy, BRAIN COMMUNICATIONS, 5(6), fcad281, 20231101
    Link to Paper Search Results by DOI
  50. Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment, FRONTIERS IN NEUROSCIENCE, 17, 1250547, 20231023
    Link to Paper Search Results by DOI
  51. Swallowing sound evaluation using an electronic stethoscope and artificial intelligence analysis for patients with amyotrophic lateral sclerosis, FRONTIERS IN NEUROLOGY, 14, 1212024, 20230803
    Link to Paper Search Results by DOI
  52. Association between Carotid Wall Shear Stress-Based Vascular Vector Flow Mapping and Cerebral Small Vessel Disease, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 30(9), 1165-1175, 2023
    Link to Paper Search Results by DOI
  53. Exacerbation of Repetitive Falls Due to Atonic Seizures Following Perampanel Administration, CUREUS JOURNAL OF MEDICAL SCIENCE, 15(6), e40818, 20230622
    Link to Paper Search Results by DOI
  54. CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis, AMERICAN JOURNAL OF HUMAN GENETICS, 110(7), 1086-1097, 20230706
    Link to Paper Search Results by DOI
  55. Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection, PLOS ONE, 18(6), e0287545, 20230623
    Link to Paper Search Results by DOI
  56. Impact of neck percutaneous interferential current sensory stimulation on swallowing function in patients with Parkinson's disease: A single-arm, open-label study protocol, CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS, 33, 101158, 202306
    Link to Paper Search Results by DOI
  57. Case report: Mitochondrial trifunctional protein deficiency caused by HADHB gene mutation (c.1175C>T) characterized by higher brain dysfunction followed by neuropathy, presented gadolinium enhancement on brain imaging in an adult patient, FRONTIERS IN NEUROLOGY, 14, 1187822, 20230613
    Link to Paper Search Results by DOI
  58. Reversible Brain Atrophy in Cryptogenic New-onset Refractory Status Epilepticus, INTERNAL MEDICINE, 62(12), 1835-1842, 2023
    Link to Paper Search Results by DOI
  59. Nerve Ultrasonography for the Diagnosis and Evaluation of Neuralgic Amyotrophy, INTERNAL MEDICINE, 62(12), 1843-1847, 2023
    Link to Paper Search Results by DOI
  60. On-scene time delays for epileptic seizures in emergencies during a social pandemic: A population-based study, EPILEPSY & BEHAVIOR, 142, 109211, 202305
    Link to Paper Search Results by DOI
  61. A case of ischemic stroke associated with protein-losing gastroenteropathy and protein S deficiency, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 32(7), 107151, 202307
    Link to Paper Search Results by DOI
  62. Paradoxical effects of levetiracetam in people with epilepsy with rhythmic epileptiform discharges, EPILEPSY & BEHAVIOR, 143, 109225, 202306
    Link to Paper Search Results by DOI
  63. Clinical diagnostic criteria of benign adult familial myoclonus epilepsy type 1 are highly concordant with genetic testing, NEUROLOGY AND CLINICAL NEUROSCIENCE, 11(3), 140-145, 202305
    Link to Paper Search Results by DOI
  64. Features of repetitive nerve stimulation and nerve conduction studies in patients with amyotrophic lateral sclerosis, NEUROLOGY AND CLINICAL NEUROSCIENCE, 11(3), 134-139, 202305
    Link to Paper Search Results by DOI
  65. Encephalopathy after COVID-19 vaccination during treatment with nivolumab: A case report, CLINICAL NEUROLOGY AND NEUROSURGERY, 226, 107632, 202303
    Link to Paper Search Results by DOI
  66. Morphological study of the phrenic nerve to determine a reference value for the myelinated fiber density in elderly individuals, NEUROPATHOLOGY, 43(2), 129-134, 202304
    Link to Paper Search Results by DOI
  67. Immediate and 6-month seizure outcomes following first and second SARS-CoV2 mRNA vaccinations: A multicenter study with a nationwide survey, EPILEPSY & BEHAVIOR, 139, 109070, 202302
    Link to Paper Search Results by DOI
  68. Periapical lesion following Cnm-positive Streptococcus mutans pulp infection worsens cerebral hemorrhage onset in an SHRSP rat model, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 210(3), 321-330, 20221231
    Link to Paper Search Results by DOI
  69. The association between nutritional intake one week after admission and outcome in acute ischemic stroke patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 31(11), 106812, 202211
    Link to Paper Search Results by DOI
  70. A case of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations: Long-term treatment with repeated courses of immunotherapy, NEUROLOGY AND CLINICAL NEUROSCIENCE, 10(6), 321-324, 202211
    Link to Paper Search Results by DOI
  71. Gastrointestinal cancer occurs as extramuscular manifestation in FSHD1 patients, JOURNAL OF HUMAN GENETICS, 68(2), 91-95, 202302
    Link to Paper Search Results by DOI
  72. Are patients with Parkinson's disease at a lower risk of catching the common cold? Propensity score matching, PARKINSONISM & RELATED DISORDERS, 106, 105227, 202301
    Link to Paper Search Results by DOI
  73. Detecting motor unit abnormalities in amyotrophic lateral sclerosis using high-density surface EMG, CLINICAL NEUROPHYSIOLOGY, 142, 262-272, 202210
    Link to Paper Search Results by DOI
  74. TDP-43 Accumulation Within Intramuscular Nerve Bundles of Patients With Amyotrophic Lateral Sclerosis, JAMA NEUROLOGY, 79(7), 693-701, 202207
    Link to Paper Search Results by DOI
  75. Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis A Randomized Clinical Trial, JAMA NEUROLOGY, 79(6), 575-583, 202206
    Link to Paper Search Results by DOI
  76. Compassionate open-label use of rituximab following a randomised clinical trial against neuromyelitis optica (RIN-2 study): B cell monitoring-based administration, MULTIPLE SCLEROSIS AND RELATED DISORDERS, 60, 103730, 202204
    Link to Paper Search Results by DOI
  77. Various effects of nutritional status on clinical outcomes after intracerebral hemorrhage, INTERNAL AND EMERGENCY MEDICINE, 17(4), 1043-1052, 202206
    Link to Paper Search Results by DOI
  78. Assessment of Serum IgG Titers to Various Periodontal Pathogens Associated with Atrial Fibrillation in Acute Stroke Patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 31(3), 106301, 202203
    Link to Paper Search Results by DOI
  79. Clinical characteristics and tumor markers in ischemic stroke patients with active cancer, INTERNAL AND EMERGENCY MEDICINE, 17(3), 735-741, 202204
    Link to Paper Search Results by DOI
  80. Autopsy Validation of the Diagnostic Accuracy of I-123-Metaiodobenzylguanidine Myocardial Scintigraphy for Lewy Body Disease, NEUROLOGY, 98(16), E1648-E1659, 20220419
    Link to Paper Search Results by DOI
  81. Clinical Factors Predicting Voluntary Driving Cessation among Patients with Parkinson's Disease, BEHAVIOURAL NEUROLOGY, 2022, 804702, 20220320
    Link to Paper Search Results by DOI
  82. Characteristics of cause of death and triggers for crisis in patients with myasthenia gravis, NEUROLOGY AND CLINICAL NEUROSCIENCE, 10(3), 147-154, 202205
    Link to Paper Search Results by DOI
  83. Seizure Deterioration with Increased Levetiracetam Blood Concentration during the Postpartum Period in Refractory Temporal Lobe Epilepsy, INTERNAL MEDICINE, 61(8), 1237-1240, 2022
    Link to Paper Search Results by DOI
  84. A longitudinal seizure outcome following the COVID-19 pandemic in 2020 and 2021: Transient exacerbation or sustainable mitigation, JOURNAL OF THE NEUROLOGICAL SCIENCES, 434, 120100, 20220315
    Link to Paper Search Results by DOI
  85. Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle- Brachial Index, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 29(5), 719-730, 2022
    Link to Paper Search Results by DOI
  86. Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process, FRONTIERS IN MOLECULAR NEUROSCIENCE, 15, 804702, 20220211
    Link to Paper Search Results by DOI
  87. Laterality of the activation of the vastus lateralis muscle in females with Parkinson's disease during the medication state compared with healthy controls, JOURNAL OF INTEGRATIVE NEUROSCIENCE, 21(1), 1-8, 20220128
    Link to Paper Search Results by DOI
  88. Knockdown of optineurin controls C2C12 myoblast differentiation via regulating myogenin and MyoD expressions, DIFFERENTIATION, 123, 1-8, 202201
    Link to Paper Search Results by DOI
  89. Screening for non-convulsive status epileptics with density spectrum array in critical care EEG., QJM, 114(12), 893-894, 2021
  90. A case of repetitive seizures following immune checkpoint inhibitor therapy as a feature of autoimmune encephalitis., Epileptic Disorders, 23(5), 733-738, 202110
  91. A role of aging in the progression of cortical excitability in Benign Adult Familial Myoclonus Epilepsy type 1 patients., Movement Disorders, 36(10), 2446-2448, 202110
  92. Nationwide online EEG education during coronavirus disease 2019 pandemic., Clinical Neurophysiology, 132, 2763-2765, 2021
  93. Extreme delta brush in anti-NMDAR encephalitis: mimics and chameleons., Epilepsia Open, 6, 443-446, 2021
  94. Emotional facial paresis in temporal lobe epilepsy., Internal Medicien, 60, 2705-2706, 2021
  95. Detailed neuronal distribution of GPR3 and its co-expression with EF-hand calcium-binding proteins in the mouse central nervous system, BRAIN RESEARCH, 1750, 147166, 20210101
    Link to Paper Search Results by DOI
  96. Prospective Memory Deficits in Multiple Sclerosis: Voxel-based Morphometry and Double Inversion Recovery Analysis, INTERNAL MEDICINE, 60(1), 39-46, 2021
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  97. Krebs von den Lungen 6 decreased in the serum and muscle of GNE myopathy patients, NEUROPATHOLOGY, 41(1), 29-36, 202102
    Link to Paper Search Results by DOI
  98. Association between stroke lesions and videofluoroscopic findings in acute stroke patients, JOURNAL OF NEUROLOGY, 268(3), 1025-1035, 202103
    Link to Paper Search Results by DOI
  99. Low-dose Contrast-induced Encephalopathy During Diagnostic Cerebral Angiography, INTERNAL MEDICINE, 60(4), 629-633, 2021
    Link to Paper Search Results by DOI
  100. Identification of the laterality of motor unit behavior in female patients with parkinson's disease using high-density surface electromyography, EUROPEAN JOURNAL OF NEUROSCIENCE, 53(6), 1938-1949, 202103
    Link to Paper Search Results by DOI
  101. The Effect of Electrical Muscle Stimulation on Muscle Mass and Balance in Older Adults with Dementia, BRAIN SCIENCES, 11(3), 202103
    Link to Paper Search Results by DOI
  102. cnm-Positive Streptococcus mutans and diffusion-weighted imaging hyperintensities in acute intracerebral hemorrhage, EUROPEAN JOURNAL OF NEUROLOGY, 28(5), 1581-1589, 202105
    Link to Paper Search Results by DOI
  103. An autopsy report of a familial amyotrophic lateral sclerosis case carrying VCP Arg487His mutation with a unique TDP43 proteinopathy, NEUROPATHOLOGY, 41(2), 118-126, 202104
    Link to Paper Search Results by DOI
  104. Socio-economic impact on epilepsy outside of the nation-wide COVID-19 pandemic area, EPILEPSY & BEHAVIOR, 117, 202104
    Link to Paper Search Results by DOI
  105. Impact of anatomical variations on ultrasonographic reference values of lower extremity peripheral nerves, MUSCLE & NERVE, 63(6), 890-896, 202106
    Link to Paper Search Results by DOI
  106. Giant Cell Arteritis with Internal Carotid Artery Occlusion in the Absence of Typical Clinical Features, INTERNAL MEDICINE, 60(8), 1293-1297, 202104
    Link to Paper Search Results by DOI
  107. Optineurin defects cause TDP43-pathology with autophagic vacuolar formation, NEUROBIOLOGY OF DISEASE, 148, 202101
    Link to Paper Search Results by DOI
  108. Rapid ping-pong eye deviation following a recovery from carbon dioxide narcosis, BMJ CASE REPORTS, 14(3), 202103
    Link to Paper Search Results by DOI
  109. External cervical resorption detected via cone-beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody-associated disease: A case report, CLINICAL CASE REPORTS, 9(7), 202107
    Link to Paper Search Results by DOI
  110. RNF213 p.R4810K (c.14429G > A) Variant Determines Anatomical Variations of the Circle of Willis in Cerebrovascular Disease, FRONTIERS IN AGING NEUROSCIENCE, 13, 20210715
    Link to Paper Search Results by DOI
  111. Influence of current and previous smoking on current phenotype in Parkinson's disease, JOURNAL OF THE NEUROLOGICAL SCIENCES, 427, 20210815
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  112. Analysis of genetic risk factors in Japanese patients with Parkinson's disease, JOURNAL OF HUMAN GENETICS, 66(10), 957-964, 202110
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  113. The effect of electrical muscle stimulation on quadriceps muscle strength and activation patterns in healthy young adults, EUROPEAN JOURNAL OF SPORT SCIENCE, 21(10), 1414-1422, 20211003
    Link to Paper Search Results by DOI
  114. Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson's Disease Patients, SENSORS, 21(19), 202110
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  115. FXTAS is difficult to differentiate from neuronal intranuclear inclusion disease through skin biopsy: a case report, BMC NEUROLOGY, 21(1), 20211012
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  116. The Effect of a Portable Electrical Muscle Stimulation on Brain-Derived Neurotrophic Factor in Elderly People: Three Case Studies, GERONTOLOGY AND GERIATRIC MEDICINE, 7, 20210819
    Link to Paper Search Results by DOI
  117. Case of Neuronal Intranuclear Inclusion Disease With Dynamic Perfusion Changes Lacking Typical Signs on Diffusion-Weighted Imaging, NEUROLOGY-GENETICS, 7(4), 202108
    Link to Paper Search Results by DOI
  118. Utility of Magnetic Resonance Spectroscopy for the Progression of Neurological Symptoms in Lenticulostriate Artery Territory Infarction, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 30(6), 105747, 202106
    Link to Paper Search Results by DOI
  119. Study Protocol for a Randomized, Double-Blind, Placebo-Controlled, Phase-II Trial: AdrenoMedullin for Ischemic Stroke Study, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 30(6), 105761, 202106
    Link to Paper Search Results by DOI
  120. Efficacy of Lacosamide in a Patient with Refractory Generalized Epilepsy Based on Video Electroencephalography, INTERNAL MEDICINE, 60(22), 3621-3624, 2021
    Link to Paper Search Results by DOI
  121. Focal hyperperfusion and elevated lactate in the cerebral lesions with anti-GABAaR encephalitis: a serial MRI study., Journal of Neuroradiology, 47(3), 243-246, 2020
  122. Retinitis pigmentosa prior to familial ALS caused by a homozygous cilia and flagella-assosicated protein 410 mutation, Journal of Neurology, Neurosurgery, and Psychiatry, 91(2), 220-222, 2020
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  260. Structure and regulation of the human NeuroD (BETA2/BHF1) gene, Molecular Brain Research, 69(2), 223-231, 19990601
  261. Characteristic magnetic resonance findings in Machado-Joseph Disease., Archives of Neurology., 55(1), 33-37, 19980401
  262. CAG repeat length and disease duration in Machado-Joseph disease: a new clinical classification., J. Neurol. Sci., 152(2), 166-171, 19970201
  263. Molecular features of the CAG repeats of spinocerebellar ataxia 6 (SCA6)., Hum Mol Genet, 6(8), 1283-1287, 19970401
  264. Homozygosity for an allele carrying intermediate CAG repeats in the dentatorubral-pallidoluysian atrophy (DRPLA) gene results in spastic paraplegia., Neurology, 48(4), 1087-1090, 19970401
  265. Clonig and expression of a rat brain basic helix-loop-helix factor 1(BHF1)., Biochem. Biophys. Res. Comm., 221, 199-204, 19960401
  266. Reevaluation of the exact CAG repeat length in hereditary cerebellar ataxias using highly denaturing conditions and long PCR., Hum.Genet., 97(5), 591-595, 19960501
  267. A family with Machado-Joseph disease, previously diagnosed as dentatorubral-pallidoluysian atrophy., Neurology, 46(4), 1154-1156, 19960401
  268. Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to Neuro-D/BHF1., Biochem. Biophys. Res. Commun., 220(3), 754-758, 19960401
  269. Homozygosity for Machado-Joseph disease gene enhances phenotypic severity., J Neurol Neurosurg Psychiatry, 60(3), 354-356, 19960301
  270. ★, Molecular features of the CAG repeats and clinical manifestation of Machado-Joseph disease., Hum Mol Genet, 4(5), 807-812, 19950401
  271. Unique features of the CAG repeats in Machado-Joseph disease., Nat Genet, 9(4), 344-345, 19950401
  272. An autopsied case of ADSSL1 myopathy, NEUROMUSCULAR DISORDERS, 31(11), 1220-1225, 202111
    Link to Paper Search Results by DOI
  273. Predictors of Stroke Outcome Extracted from Multivariate Linear Discriminant Analysis or Neural Network Analysis, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 29(1), 99-110, 2022
    Link to Paper Search Results by DOI

Publications such as books

  1. 1996, International Academy for Biological and Drug Research (T Shibuya ed), Glutamate transporter and neurodegenerative diseases, 1996, Scholarly Book, Joint work, Shigenobu Nakamura, Hideshi Kawakami, Kohichi Tanaka, Takayasu Nakayama, Hiroshi Yamashita, Yu-Xiang Zhang, Ken Inoue, Hirofumi Maruyama, Setsuo Takai, Kiyomi Yamada, 32-40
  2. 2001, Neuroscientific Basis of Dementia (Tanaka C, McGeer PL, Ihara Y eds), Risk factors for dementia, 2001, Scholarly Book, Joint work, Nakamura S, Maruyama H, Toji H, Kawakami H, Yamada M, Mimori Y, 279-286

Invited Lecture, Oral Presentation, Poster Presentation

  1. Association of estrogen receptor alpha gene polymorphisms and transcriptional activity with Alzheimer's disease, Hirofumi Maruyama, 17th ISN/13th ESN Joint Meeting, 1999, Without Invitation, English
  2. Causative gene of amyotrophic lateral sclerosis: optineurin, Hirofumi Maruyama, 60th Annual Meeting of The American Society of Human Genetics, 2010, Without Invitation, English

Awards

  1. 2010/10/29, Encouragement Award of Japan Society of Human Genetics, Japan Society of Human Genetics, Identification of causative gene of amyotrophic lareral sclerosis; optineurin
  2. 2011/05/18, Award of Japanese Society of Neurology, Japanese Society of Neurology, Identification of new causative gene of amyotrophic lateral sclerosis; optineurin
  3. 2011/11/01, Encouragement Award of Japan Medical Association, Japan Medical Association, Construction and Evaluation of ALS model mouse for optineurin

External Funds

Acceptance Results of Competitive Funds

  1. Funding Program for Next Generation World-Leading Researchers, Reseach on mechanisms of optineurin and related subjects in amyotrophic lateral sclerosis, 2011/02/10, 2014/03/31

Social Activities

History as Committee Members

  1. Chief of the Center, 2019/04, 2026/03, Center for Intractable Disease Control (Hiroshima)

History as Peer Reviews of Academic Papers

  1. 2024, Neuroscience, Others, Reviewer, 1
  2. 2024, Nature Communications, Others, Reviewer, 1
  3. 2025, Acta Neurologica Scandinavica, Others, Reviewer, 1
  4. 2024, Journal of the Neurological Sciences, Others, Reviewer, 2
  5. 2024, Neurology and Clinical Neuroscience, Others, Reviewer, 2
  6. 2024, Hiroshima Journal of Medical Sciences, Editor, Associate Editors