TOSHIO NAKAMAE

Last Updated :2024/05/08

Affiliations, Positions
Hiroshima University Hospital(Medical), Associate Professor or Lecturer
E-mail
nakamaethiroshima-u.ac.jp

Basic Information

Educational Backgrounds

  • Hiroshima University, Faculty of Medicine, Japan, 1995/04, 2001/03
  • Hiroshima University, Graduate School of Biomedical Sciences, Japan, 2006/04, 2010/03

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Orthopaedic surgery

Research Keywords

  • spine surgery low back pain osteoporotic vertebral fracture sports medicine

Affiliated Academic Societies

  • the Japanese Society for Spine Surgery and Related Research
  • The Central Japan Journal of Orthopaedic Surgery & Traumatology
  • the Chugoku-Shikoku Orthopaedic Association
  • THE WESTERN JAPANESE RESEARCH SOCIETY FOR SPINE
  • Japanese Society of Lumbar Spine Disorders
  • The Japanese Orthopaedic Society for Sports Medicine
  • International Society for the Study of the Lumbar Spine (ISSLS)
  • Japanese society for study of spinal cord function
  • Society for Minimally Invasive Spinal Treatment

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Year, Clinical diagnosis and treatment II
  2. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  3. 2024, Undergraduate Education, 2Term, Surgery II

Research Activities

Academic Papers

  1. Vertebral osteomyelitis due to Mycobacterium abscessus subsp. massiliense with paravertebral abscess: A case report and review, JOURNAL OF INFECTION AND CHEMOTHERAPY, 29(9), 922-926, 202309
    Link to Paper Search Results by DOI
  2. Foramen Magnum Decompression with Outer Dura Matter Layer Resection for Chiari Type I Malformation: Factors Correlated with Syrinx Reduction, ASIAN SPINE JOURNAL, 17(2), 365-372, 202304
    Link to Paper Search Results by DOI
  3. Differentiation between compressive cervical and thoracic myelopathy using the central motor conduction time ratio, Journal of Clinical Neurophysiology, 2022
  4. Microcervical Foraminotomy for Cervical Juxtafacet Cysts: Case Series and Literature Review, Int J Spine Surg., 2023
  5. Differentiating Neurodegenerative Disease from Compressive Cervical Myelopathy Using Motor Evoked Potentials, Spine, 2023
  6. Prognostic factors of balloon kyphoplasty for osteoporotic vertebral fractures with diffuse idiopathic skeletal hyperostosis, J Neurosurg Spine, 2023
  7. Balancing ability of patients with lumbar spinal canal stenosis, European Spine Journal, 2023
  8. Physical signs and clinical features with cervical myelopathy of elderly patients, especially 80 years or older: Comparison of three generations in 100 consecutive operative cases, Asian Spine J., 2023
  9. Sacral stress fracture in athletes with overuse: a clinical series of ten patients and review of literature, Clin Spine Surg., 2023
  10. Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System, NEURAL PLASTICITY, 2023, 20230322
    Link to Paper Search Results by DOI
  11. Percutaneous Intervertebral-Vacuum Polymethylmethacrylate Injection for Foraminal Stenosis with Degenerative Lumbar Scoliosis, WORLD NEUROSURGERY, 165, E712-E720, 202209
    Link to Paper Search Results by DOI
  12. Primary Spinal Cord Melanoma: A Two-Case Report and Literature Review, SPINE SURGERY AND RELATED RESEARCH, 6(6), 717-720, 2022
    Link to Paper Search Results by DOI
  13. Differences between spinal cord injury and cervical compressive myelopathy in intramedullary high-intensity lesions on T2-weighted magnetic resonance imaging: A retrospective study, MEDICINE, 101(34), 20220826
    Link to Paper Search Results by DOI
  14. Development of a rat model with lumbar vertebral endplate lesion, Eur Spine J., 2022
  15. Percutaneous intervertebral-vacuum polymethylmethacrylate injection for foraminal stenosis with degenerative lumbar scoliosis, World Neurosurgery, 2022
  16. Comparison of the electrophysiological characteristics of tight filum terminale and tethered cord syndrome, ACTA NEUROCHIRURGICA, 164(8), 2235-2242, 202208
    Link to Paper Search Results by DOI
  17. Evaluation of intervertebral disc degeneration using T2 signal ratio on magnetic resonance imaging, EUROPEAN JOURNAL OF RADIOLOGY, 152, 202207
    Link to Paper Search Results by DOI
  18. Radiographic Factors for Adjacent Vertebral Fractures and Cement Loosening Following Balloon Kyphoplasty in Patients with Osteoporotic Vertebral Fractures, SPINE SURGERY AND RELATED RESEARCH, 6(2), 159-166, 2022
    Link to Paper Search Results by DOI
  19. Quantitative Assessment of Bone Marrow Edema in Adolescent Athletes with Lumbar Spondylolysis Using Contrast Ratio on Magnetic Resonance Imaging, ASIAN SPINE JOURNAL, 15(5), 682-687, 202110
    Link to Paper Search Results by DOI
  20. Relationship between clinical symptoms of osteoporotic vertebral fracture with intravertebral cleft and radiographic findings., J Orthop Sci, 22(2), 201-206, 2017
  21. Pathology and Treatment of Traumatic Cervical Spine Syndrome: Whiplash Injury, ADVANCES IN ORTHOPEDICS, 2018
    Link to Paper Search Results by DOI
  22. Chondroitinase ABC promotes corticospinal axon growth in organotypic cocultures, Spinal Cord, 47(2), 161-165, 2008
  23. Quantitative assessment of myelopathy patients using motor evoked potentials produced by transcranial magnetic stimulation, Eur Spine J, 19(5), 685-690, 2010
  24. The effect of an external magnetic force on cell adhesion and proliferation of magnetically labeled mesenchymal stem cells, Sports Med Arthrosc Rehabil Ther Technol, 2(1), 5-5, 2010
  25. The effects of combining chondroitinase ABC and NEP1-40 on the corticospinal axon growth in organotypic co-cultures, Neurosci Lett, 476(1), 14-17, 2010
  26. Pharmacological inhibition of TNF may reduce pain behavior changes induced by experimental disc puncture in the rat, Spine, 36(4), 232-236, 2011
  27. The usefulness of motor evoked potentials produced by transcranial magnetic stimulation for the patients with myelopathy, Journal of Spine Research, 2(2), 215-219, 2011
  28. Investigation of segmental motor paralysis after cervical laminoplasty using intraoperative spinal cord monitoring with transcranial electric motor evoked potentials, Journal of spinal disorders and techniques, 25(2), 92-98, 2012
  29. Surgical treatment of high-grade dysplastic spondylolisthesis using intraoperative electrophysiological monitoring: report of two cases and review of the literature, European Journal of Orthopaedic Surgery & Traumatology, 23(1), 121-127, 2013
  30. ★, Percutaneous vertebroplasty for osteoporotic vertebral compression fracture with intravertebral cleft associated with delayed neurologic deficit, European Spine Journal, 22(7), 1624-1632, 2013
  31. Efficacy of Percutaneous Vertebroplasty in the Treatment of Osteoporotic Vertebral Compression Fractures with Intravertebral Cleft, The Open Orthopaedics Journal, 9, 107-113, 2015
  32. ★, Bone Marrow Edema and Low Back Pain in Elderly Degenerative Lumbar Scoliosis: A Cross-sectional Study, Spine, 41(10), 885-892, 2016
  33. Risk factors for cement loosening after vertebroplasty for osteoporotic vertebral fracture with intravertebral cleft: a retrospective analysis, Asian Spine J, 12(5), 935-942, 2017
  34. Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome with destructive spondylitis: a case report, Spine Surgery and Related Research, 2018
  35. Expansive laminoplasty for cervical myelopathy with interconnected porous calcium hydroxyapatite ceramic spacers: comparison with autogenous bone spacers, J Spinal Disord Tech, 21(8), 547-552, 2008
  36. CD133+ cells from human peripheral blood promote corticospinal axon regeneration, Neuroreport, 19(8), 799-803, 2008
  37. Clinical results of cervical myelopathy in patients older than 80 years of age: evaluation of spinal function with motor evoked potentials, J Neurosurg Spine, 11(4), 421-426, 2009
  38. Assessment of central motor conduction time in the diagnosis of compressive thoracic myelopathy, Spine, 35(26), 1593-1598, 2010
  39. CD133+ cells from human umbilical cord blood reduce cortical damage and promote axonalgrowth in neonatal rat organ co-cultures exposed to hypoxia, Int J Dev Neurosci, 28(7), 581-587, 2010
  40. Pain behavior changes following disc puncture relate to nucleus pulposus rather than to the disc injury per se: an experimental study in rats, Open Orthop J, 5, 72-77, 2011
  41. MicroRNA-223 expression in neutrophils in the early phase of secondary damage after spinalcord injury, Neurosci Lett, 492(2), 114-118, 2011
  42. Magnetic Field-based Delivery of Human CD133 Positive Cells Promotes Functional Recovery Following Rat Spinal Cord Injury, Spine, 37(13), 768-777, 2012
  43. Heme oxygenase-1 modulates degeneration of the intervertebral disc after puncture in Bach 1 deficient mice, Eur Spine J, 21(9), 1748-1757, 2012
  44. Long-term clinical results of microsurgical transdural discectomy with laminoplasty: follow-up results over 10 years, J Neurosurg Spine, 18(6), 653-660, 2013
  45. Use of prone position magnetic resonance imaging for detecting the terminal filum in patients with occult tethered cord syndrome, J Neurosurg Spine, 18(1), 76-84, 2013
  46. Medium-term Clinical Results of Microsurgical Lumbar Flavectomy That Preserves Facet Joints in Cases of Lumbar Degenerative Spondylolisthesis: Comparison of Bilateral Laminotomy With Bilateral Decompression by a Unilateral Approach, J Spinal Disord Tech, 26(7), 351-358, 2015
  47. Clinical results of microsurgical bilateral decompression via unilateral approach for lumbar canal stenosis with multiple-level involvement, Eur J Orthop Surg Traumatol, 25(1), 191-198, 2015
  48. Targeted Therapy for Low Back Pain in Elderly Degenerative Lumbar Scoliosis: A Cohort Study, Spine, 41(10), 872-879, 2016
  49. Novel hybrid hydroxyapatite spacers ensure sufficient bone bonding in cervical laminoplasty, Asian Spine Journal, 2018
  50. Electrophysiological Assessment and Classification of Motor Pathway Function in Patients with Spinal Dural Arteriovenous Fistula, J Clin Neurophysiol, 36(1), 45-51, 201901
  51. Electrophysiological Assessment and Classification of Motor Pathway Function in Patients With Spinal Dural Arteriovenous Fistula, JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 36(1), 45-51, 201901
    Link to Paper Search Results by DOI
  52. The correlation between sagittal spinopelvic alignment and degree of lumbar degenerative spondylolisthesis, JOURNAL OF ORTHOPAEDIC SCIENCE, 24(6), 969-973, 201911
    Link to Paper Search Results by DOI
  53. Transforaminal percutaneous endoscopic discectomy for lumbar disc herniation in athletes under the local anesthesia, JOURNAL OF ORTHOPAEDIC SCIENCE, 24(6), 1015-1019, 201911
    Link to Paper Search Results by DOI
  54. A Case Report of a Japanese Boy with Morquio A Syndrome: Effects of Enzyme Replacement Therapy Initiated at the Age of 24 Months, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(3), 202002
    Link to Paper Search Results by DOI
  55. Long-Term Outcome of Targeted Therapy for Low Back Pain in Elderly Degenerative Lumbar Scoliosis, Eur Spine J, 30(7), 2020-2032, 2021
  56. Quantifying bone marrow edema adjacent to the lumbar vertebral endplate on magnetic resonance imaging: a cross sectional study of patients with chronic low back pain, Asian Spine J., 2022
  57. Spinous process fractures in osteoporotic vertebral fractures: a cross-sectional study, Spine Surgery and Related Research, 2021
  58. Surgical outcomes of cervical myelopathy in patients with athetoid cerebral palsy, Eur J Orthop Surg Traumatol, 2021
  59. Quantitative evaluation of abnormal finger movements in myelopathy hand during the grip and release test using gyro sensors, PLOS ONE, 16(10), 20211020
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Spinous process fractures in osteoporotic vertebral fractures: a cross-sectional study of patients with low back pain, Nakamae T, 2023 EuroSpine, 2023, Without Invitation, English
  2. Surgical outcomes of cervical myelopathy in patients with athetoid cerebral palsy, Nakamae T, 13th Annual Meeting of Cervical Spine Research Society -Asia Pacific Section, 2023, Without Invitation, English
  3. Spinous process fractures in osteoporotic vertebral fractures: a cross-sectional study of patients with low back pain., Nakamae T, ISSLS (International Society for the Study of the Lumbar Spine), 2022, Without Invitation, English
  4. Short-segmental spinal fusion for chronic low back pain with bone marrow edema adjacent to the vertebral endplate in adult spinal deformity., Nakamae T, ISSLS (International Society for the Study of the Lumbar Spine), 2022, Without Invitation, English
  5. Spinous process fractures in osteoporotic vertebral fractures, Nakamae T, the 13th Combined Meeting of Asia Pacific Spine Society & Asia Pacific Paediatric Orthopaedic Society, 2021, Without Invitation, English
  6. Short-segmental spinal fusion for chronic low back pain with bone marrow edema adjacent to the vertebral endplate, Nakamae T, the 13th Combined Meeting of Asia Pacific Spine Society & Asia Pacific Paediatric Orthopaedic Society, 2021, Without Invitation, English
  7. Association of vertebral bone marrow edema with low back pain in degenerative lumbar scoliosis in the elderly, Toshio Nakamae, ISSLS (International Society for the Study of the Lumbar Spine), 2019, Without Invitation, English
  8. Pathology and treatment for cervical flexion myelopathy, Toshio Nakamae, 10th Annual Meeting of Cervical Spine Research Society - Asia Pacific Section, 2019, Without Invitation, English
  9. Treatment for Cervical Myelopathy Associated with Athetoid Cerebral Palsy, Toshio Nakamae, 10th Annual Meeting of Cervical Spine Research Society - Asia Pacific Section, 2019, Without Invitation, English
  10. Association of vertebral bone marrow edema with low back pain in degenerative lumbar scoliosis in the elderly: A cross-sectional observational study, Nakamae T, THE 23rd SPINE SOCIETY OF HCM CITY, VIET NAM & THE 8TH KHANH HOA INTERNATIONAL SPINE MEETING, 2018, Without Invitation, English
  11. Percutaneous endoscopic discectomy for lumbar disc herniation in athletes, Nakamae T, ISSLS (International Society for the Study of the Lumbar Spine), 2018, Without Invitation, English
  12. Chronic Low Back Pain in the Elderly:Osteoporotic Vertebral Fracture and Degenerative Lumbar Scoliosis, Nakamae T, Study Group of Nerve and Spine (SGNS), 2017, With Invitation, English
  13. Risk factors predicting cement loosening after percutaneous vertebroplasty for osteoporotic vertebral fracture with intravertebral cleft: a retrospective analysis, Nakamae T, NASS2018 (North American Spine Society), 2017, Without Invitation, English
  14. Percutaneous vertebroplasty for osteoporotic vertebral fracture associated with delayed neurologic deficit in thoracolumbar spine, Nakamae T, ISSLS (International Society for the Study of the Lumbar Spine), 2017, Without Invitation, English
  15. Risk factors predicting cement loosening after percutaneous vertebroplasty for osteoporotic vertebral fracture with intravertebral cleft: a retrospective analysis, ISSLS (International Society for the Study of the Lumbar Spine), 2017, Without Invitation, English
  16. Pathophysiology and treatment for cervical flexion myelopathy, Nakamae T, THE 23rd SPINE SOCIETY OF HCM CITY, VIET NAM & THE 8TH KHANH HOA INTERNATIONAL SPINE MEETING, 2017, Without Invitation, English
  17. Relationship between clinical symptoms of osteoporotic vertebral fracture with intravertebral cleft and radiographic findings, Nakamae T, ISSLS (International Society for the Study of the Lumbar Spine), 2016, Without Invitation, English
  18. Percutaneous vertebroplasty for osteoporotic vertebral fracture with intravertebral cleft: analysis of poor clinical outcome, Nakamae T, Asia Pacific Spine Society, 2016, Without Invitation, English
  19. Association of Vertebral Bone Marrow Edema with Low Back Pain in Degenerative Lumbar Scoliosis in the Elderly: A Cross-sectional Observational Study, Nakamae T, The International Society for the Study of the Lumbar Spine (ISSLS) 2015, 2015, Without Invitation, English
  20. Tergeted therapy of low back pain associated with degenerative lumbar scoliosis in the elderly: observation cohort study, Orthopaedic Research Society 2015, 2015, Without Invitation, English
  21. Association of Vertebral Bone Marrow Edema with Low Back Pain in Degenerative Lumbar Scoliosis in the Elderly: A Cross-sectional Observational Study, Nakamae T, Orthopaedic Research Society 2015, 2015, Without Invitation, English
  22. Pathology and treatment for cervical flexion myelopathy (juvenile muscular atrophy of unilateral upper extremity), Nakamae T, 5th CSRS-AP (Cervical Spine Research Society Asia-Pacific section), 2014, Without Invitation, English
  23. Percutaneous vertebroplasty for osteoporotic vertebral fracture associated with delayed neurologic deficit, Nakamae T, ISMISS (International Society for Minimally Intervention in Spinal Surgery), 2013, Without Invitation, English
  24. Motor evoked potentials produced by transcranial magnetic stimulation is useful tool to assess cervical myelopathy patients, Nakamae T, Euro Spine, SpineWeek 2012, 2012, Without Invitation, English
  25. Investigation of segmental motor paralysis after cervical laminoplasty using intraoperative spinal cord monitoring with transcranial electric motor evoked potentials, Nakamae T, CSRS-ES, SpineWeek 2012, 2012, Without Invitation, English
  26. Further support that pain behavior changes following disc puncture in the rat is induced by presence of nucleus pulposus in the spinal canal rather than the disc injury per se, Nakamae T, 38th Annual Meeting of the International Society for the Study of Lumbar Spine (ISSLS), 2011, Without Invitation, English
  27. Investigation of intraoperative spinal cord monitoring during cervical laminoplasty using transcranial electric motor evoked potentials, Nakamae T, Second Annual Meeting of Cervical Spine Research Society Asia Pacific Section, 2011, Without Invitation, English
  28. Quantitative assessment of myelopathy patients using motor evoked potentials produced by transcranial magnetic stimulation, Nakamae T, 25th Annual Meeting of North American Spine Society, 2010, Without Invitation, English
  29. Quantitative assessment of myelopathy patients using motor evoked potentials produced by transcranial magnetic stimulation, Nakamae T, 1st Annual Meeting of Cervical Spine Research Society Asia Pacific Section, 2010, Without Invitation, English
  30. The effects of combining chondroitinase ABC and NEP 1-40 on the corticospinal axon growth in organotypic co-cultures of brain cortex and spinal cord., Nakamae T, 25th annual meeting of the European Section of the Cervical Spine Research Society, 2009, Without Invitation, English
  31. The effects of combining chondroitinase ABC and NEP 1-40 to the corticospinal axon growth in organotypic co-cultures of brain cortex and spinal cord, Nakamae T, 54th annual meeting of the orthopaedic research society, 2008, Without Invitation, English
  32. The cause of delayed neurologic deficits following osteoporotic vertebral pseudoarthrosis, Nakamae T, 29th NASS(North American Spine Society), Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. 2021, 2023
  2. 2019, 2020

Social Activities

History as Peer Reviews of Academic Papers

  1. 2023, Spine Surg Relat Res.
  2. 2023, Eur Spine J.
  3. 2022, Eur Spine J.
  4. 2022, Eur Spine J.
  5. 2022, Eur Spine J.
  6. 2022, J Orthop Sci
  7. 2022, Eur Spine J.
  8. 2022, Spine Surg Relat Res.
  9. 2022, Scientific Reports
  10. 2022, Asian Spine J.
  11. 2022, BMC musculoskeletal disorders
  12. 2021, Spine Surg Relat Res.
  13. 2021, Scientific Reports
  14. 2021, BMC Musculoskeletal Disorders
  15. 2021, European Spine Journal
  16. 2021, Scientific Reports
  17. 2021, European Spine Journal
  18. 2021, Spine Surgery and Related Research
  19. 2021, Asian Spine Journal
  20. 2021, Spine Surgery and Related Research
  21. 2021, Asian Spine Journal
  22. 2020, Spine Surgery and Related Research
  23. 2020, Scientific Reports
  24. 2020, Journal of pain research
  25. 2020, Asian Spine Journal
  26. 2020, European Spine Journal
  27. 2020, European Spine Journal
  28. 2015, Osteoporosis International
  29. 2015, Osteoporosis International
  30. 2016, BioMed Research International
  31. 2016, European Spine Journal
  32. 2017, European Spine Journal
  33. 2015, European Spine Journal
  34. 2014, European Spine Journal
  35. 2018, European Spine Journal
  36. 2019, Clinical Interventions in Aging
  37. 2018, PLOS ONE