濱 聖司SEIZI HAMA

Last Updated :2025/06/16

所属・職名
脳・こころ・感性科学研究センター　特任准教授
メールアドレス
shamahiroshima-u.ac.jp

基本情報

学位

  • 博士（医学）　(広島大学)

研究分野

  • 医歯薬学 / 外科系臨床医学 / 脳神経外科学
  • 複合領域 / 人間医工学 / リハビリテーション科学・福祉工学

所属学会

研究活動

学術論文（★は代表的な論文）

  1. Supra-diaphragmatic pituitary adenoma removed through the trans-tuberculum sellae approach, Neurologia Medico Chirurgica, 52巻, 2号, pp. 91-95, 20120229
  2. Growth hormone receptor expression in brain tumors, Hiroshima Journal of Medical Sciences, 61巻, 1号, pp. 1-6, 20120301
  3. Carotid arterial intraplaque hemorrhage and calcification influences cerebral hemodynamics, Neurosurgical Review, 36巻, 3号, pp. 421-427, 20130701
  4. Neuroanatomic pathways associated with poststroke affective and apathetic depression, American Journal of Geriatric Psychiatry, 21巻, 9号, pp. 840-847, 20130101
  5. Neuroanatomic pathway associated with attentional deficits after stroke, Brain Research, 1544巻, pp. 25-32, 20140128
  6. Effect of post-trochanteric groove support on stance control associated with the pelvic-lumbar system: A preliminary study, Prosthetics and Orthotics International, 39巻, 5号, pp. 405-413, 20151001
  7. Neuroanatomic pathways associated with monoaminergic dysregulation after stroke, International Journal of Geriatric Psychiatry, 32巻, 6号, pp. 633-642, 20170601
  8. Effect of Gonadotropin and Adrenocorticotropic Hormone Secretion on Invasiveness of Clinically Nonfunctioning Pituitary Adenomas: A Cell Culture Study, World Neurosurgery, 96巻, pp. 578-584.e1, 20161201
  9. High Expression of Glypican-1 Predicts Dissemination and Poor Prognosis in Glioblastomas, World Neurosurgery, 105巻, pp. 282-288, 20170901
  10. Prognostic importance of temozolomide-induced neutropenia in glioblastoma, IDH-wildtype patients, Neurosurgical Review, 41巻, 2号, pp. 621-628, 20180401
  11. Predicting ischemic stroke after carotid artery stenting based on proximal calcification and the jellyfish sign, Journal of Neurosurgery, 128巻, 5号, pp. 1280-1288, 20180501
  12. The right hemisphere is important for driving-related cognitive function after stroke, Neurosurgical Review, 44巻, 2号, pp. 977-985, 20210401
  13. Cerebrospinal fluid ctDNA and metabolites are informative biomarkers for the evaluation of CNS germ cell tumors, Scientific Reports, 10巻, 1号, 20201201
  14. Lesions in the right Rolandic operculum are associated with self-rating affective and apathetic depressive symptoms for post-stroke patients, Scientific Reports, 10巻, 1号, 20201201
  15. Pen-point Trajectory Analysis during Trail Making Test Based on a Time Base Generator Model, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS, 2021-January巻, pp. 6215-6219, 20210101
  16. Artificially-reconstructed brain images with stroke lesions from non-imaging data: modeling in categorized patients based on lesion occurrence and sparsity, Scientific Reports, 12巻, 1号, 20221201
  17. Projection of Damaged Visual and Language Regions on Low Trail Making Test Part-B Performance in Stroke Patients, Frontiers in Neurology, 13巻, 20220602
  18. Motor-cognitive functions required for driving in post-stroke individuals identified via machine-learning analysis, Journal of Neuroengineering and Rehabilitation, 20巻, 1号, 20231201
  19. Vertical dynamic visual acuity is significantly lower than horizontal dynamic visual acuity, Scientific Reports, 13巻, 1号, 20231201
  20. Author Correction: Vertical dynamic visual acuity is significantly lower than horizontal dynamic visual acuity (Scientific Reports, (2023), 13, 1, (20999), 10.1038/s41598-023-48292-1), Scientific Reports, 14巻, 1号, 20241201
  21. Transformation of rat glioma cells with the M-CSF gene inhibits tumorigenesis in vivo, Journal of Neuro-Oncology, 40巻, 3号, pp. 197-204, 199812
    DOIを用いた論文検索結果へのリンク
  22. Parasellar chronic inflammatory disease presenting Tolosa-Hunt syndrome, hypopituitarism and diabetes insipidus: a case report, Endocrine Journal, 43巻, 5号, pp. 503-510, 199610
    DOIを用いた論文検索結果へのリンク
  23. Symptomatic Rathke's cleft cyst coexisting with central diabetes insipidus and hypophysitis: case report, Endocrine Journal, 46巻, 1号, pp. 187-192, 1999
    DOIを用いた論文検索結果へのリンク
  24. Peritumoral brain edema associated with meningioma: influence of vascular endothelial growth factor expression and vascular blood supply, Cancer, 85巻, 4号, pp. 936-944, 20001119
    DOIを用いた論文検索結果へのリンク
  25. Size-adjustable titanium plate for reconstruction of the sella turcica. Technical note, Journal of Neurosurgery, 91巻, 6号, pp. 1055-1057, 199912
    DOIを用いた論文検索結果へのリンク
  26. ★, Adenovirus-mediated p16 gene transfer prevents drug-induced cell death through G1 arrest in human glioma cells, International Journal of Cancer, 77巻, 1号, pp. 47-54, 19980703
    DOIを用いた論文検索結果へのリンク
  27. Genetic immunotherapy by intrapleural, intraperitoneal and subcutaneous injection of IL-2 gene-modified Lewis lung carcinoma cells, International Journal of Cancer, 73巻, 6号, pp. 844-849, 19971210
    DOIを用いた論文検索結果へのリンク
  28. Transformation of human glioma cell lines with the p16 gene inhibits cell proliferation, ANTICANCER RESEARCH, 17巻, 3C号, pp. 1933-1938, 1997
  29. High concentrations of recombinant adenovirus expressing p16 gene induces apoptosis in lung cancer cell lines, ANTICANCER RESEARCH, 18巻, 6A号, pp. 4275-4282, 1998
  30. Overcoming multi-drug resistance using an intracellular anti-MDR1 sFv., International Journal of Cancer, 92巻, 1号, pp. 115-122, 20010401
  31. Adenovirus-mediated p16 gene transfer changes the sensitivity to taxanes and Vinca alkaloids of human ovarian cancer cells, ANTICANCER RESEARCH, 21巻, 4A号, pp. 2537-2545, 2001
  32. Preparation of purified, sterilized, and stable adenovirus vectors using albumin, Journal of Virological Methods, 103巻, 2号, pp. 191-199, 20020306
    DOIを用いた論文検索結果へのリンク
  33. Absence of mutations in the NBS1 gene in B-cell malignant lymphoma patients, ANTICANCER RESEARCH, 20巻, 3B号, pp. 1897-1900, 2000
  34. Recurrence of meningiomas, Cancer, 89巻, 5号, pp. 1102-1110, 20001113
    DOIを用いた論文検索結果へのリンク
  35. ★, Changes in the epithelium of Rathke cleft cyst associated with inflammation, Journal of Neurosurgery, 96巻, 2号, pp. 209-216, 20010925
    DOIを用いた論文検索結果へのリンク
  36. Cognitive screening test for rehabilitation using spatiotemporal data extracted from a digital trail making test part-A, HELIYON, 10巻, 13号, 20240715
    DOIを用いた論文検索結果へのリンク
  37. Vertical dynamic visual acuity is significantly lower than horizontal dynamic visual acuity, SCIENTIFIC REPORTS, 13巻, 1号, 20231128
    DOIを用いた論文検索結果へのリンク
  38. Motor-cognitive functions required for driving in post-stroke individuals identified via machine-learning analysis, Journal of NeuroEngineering and Rehabilitation, 20巻, 1号, pp. 139, 20231018
  39. Artificially-reconstructed brain images with stroke lesions from non-imaging data: modeling in categorized patients based on lesion occurrence and sparsity, Scientific Reports, 12巻, pp. 10116, 20220616
    DOIを用いた論文検索結果へのリンク
  40. Projection of Damaged Visual and Language Regions on Low Trail Making Test Part-B Performance in Stroke Patients, Frontiers in Neurology, 13巻, pp. 853942, 20220602
  41. Increased cerebrovascular reactivity in selected brain regions after extracranial-intracranial bypass improves the speed and accuracy of visual cancellation in patients with severe steno-occlusive disease: a preliminary study, Neurosurgical Review, 45巻, 3号, pp. 2257-2268, 20220130
    DOIを用いた論文検索結果へのリンク
  42. Lesions in the right Rolandic operculum are associated with self-rating affective and apathetic depressive symptoms for post-stroke patients, Scientific Reports, 10巻, 1号, pp. 20264, 20201120
    DOIを用いた論文検索結果へのリンク
  43. Relationships between motor and cognitive functions and subsequent post-stroke mood disorders revealed by machine learning analysis, Scientific Reports, 10巻, 1号, pp. 19571, 20201111
    DOIを用いた論文検索結果へのリンク
  44. Cerebrospinal fluid ctDNA and metabolites are informative biomarkers for the evaluation of CNS germ cell tumors, Scientific Reports, 10巻, 1号, pp. 14326, 20200831
    DOIを用いた論文検索結果へのリンク
  45. The right hemisphere is important for driving-related cognitive function after stroke, Neurosurgical Review, 44巻, 2号, pp. 977-985, 20200311
    DOIを用いた論文検索結果へのリンク
  46. Prognostic importance of temozolomide-induced neutropenia in glioblastoma, IDH-wildtype patients, Neurosurgical Review, 41巻, 2号, pp. 621-628, 20170909
    DOIを用いた論文検索結果へのリンク
  47. High Expression of Glypican-1 Predicts Dissemination and Poor Prognosis in Glioblastomas, World Neurosurgery, 105巻, pp. 282-288, 20170824
    DOIを用いた論文検索結果へのリンク
  48. Predicting ischemic stroke after carotid artery stenting based on proximal calcification and the jellyfish sign, Journal of Neurosurgery, 128巻, 5号, pp. 1280-1288, 20170707
    DOIを用いた論文検索結果へのリンク
  49. Neuroanatomic pathways associated with monoaminergic dysregulation after stroke, International Journal of Geriatric Psychiatry, 32巻, 6号, pp. 633-642, 20170511
    DOIを用いた論文検索結果へのリンク
  50. Effect of Gonadotropin and Adrenocorticotropic Hormone Secretion on Invasiveness of Clinically Nonfunctioning Pituitary Adenomas: A Cell Culture Study, World Neurosurgery, 96巻, pp. 578-584, 20160904
    DOIを用いた論文検索結果へのリンク
  51. p16 Gene Transfer Induces Centrosome Amplification and Abnormal Nucleation Associated with Survivin Downregulation in Glioma Cells, Pathobiology, 82巻, 1号, pp. 1-8, 20150228
    DOIを用いた論文検索結果へのリンク
  52. Effect of post-trochanteric groove support on stance control associated with the pelvic-lumbar system: A preliminary study, Prosthetics and Orthotics International, 39巻, 5号, pp. 405-413, 20140612
    DOIを用いた論文検索結果へのリンク
  53. Neuroanatomic pathway associated with attentional deficits after stroke, Brain Research, 1544巻, pp. 25-32, 20131207
    DOIを用いた論文検索結果へのリンク
  54. Neuroanatomic pathways associated with poststroke affective and apathetic depression, The American Journal of Geriatric Psychiatry, 21巻, 9号, pp. 840-847, 20130206
    DOIを用いた論文検索結果へのリンク
  55. Carotid arterial intraplaque hemorrhage and calcification influences cerebral hemodynamics, Neurosurgical Review, 36巻, 3号, pp. 421-427, 20121214
    DOIを用いた論文検索結果へのリンク
  56. Masked hyperprolactinemia: tumor-derived factors inhibiting prolactin secretion caused by pituitary-stalk damage, Journal of Clinical Neuroscience, 18巻, 12号, pp. 1651-1655, 20111019
    DOIを用いた論文検索結果へのリンク
  57. Post-operative hyponatremia in patients with pituitary adenoma: post-operative management with a uniform treatment protocol, Endocrine Journal, 58巻, 5号, pp. 373-379, 20110405
    DOIを用いた論文検索結果へのリンク
  58. Post-stroke depression and apathy: Interactions between functional recovery, lesion location, and emotional response, Psychogeriatrics, 11巻, 1号, pp. 68-76, 20110330
    DOIを用いた論文検索結果へのリンク
  59. Vulnerable carotid arterial plaque causing repeated ischemic stroke can be detected with B-mode ultrasonography as a mobile component: Jellyfish sign, Neurosurgical Review, 33巻, 4号, pp. 419-430, 20100619
    DOIを用いた論文検索結果へのリンク
  60. The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma, Anticancer Research, 29巻, 2号, pp. 597-603, 20090201
  61. 'Insistence on recovery' as a positive prognostic factor in Japanese stroke patients, Psychiatry and Clinical Neurosciences, 62巻, 4号, pp. 386-395, 20080731
    DOIを用いた論文検索結果へのリンク
  62. Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells, British Journal of Cancer, 98巻, 2号, pp. 345-355, 20080115
    DOIを用いた論文検索結果へのリンク
  63. Sitting balance as an early predictor of functional improvement in association with depressive symptoms in stroke patients, Psychiatry and Clinical Neurosciences, 61巻, 5号, pp. 543-551, 20070914
    DOIを用いた論文検索結果へのリンク
  64. Depression or apathy and functional recovery after stroke, International Journal of Geriatric Psychiatry, 22巻, 10号, pp. 1046-1051, 20070814
    DOIを用いた論文検索結果へのリンク
  65. Retinoblastoma protein prevents staurosporine-induced cell death in a retinoblastoma-defective human glioma cell line, Pathobiology, 74巻, 1号, pp. 22-31, 20070521
    DOIを用いた論文検索結果へのリンク
  66. Geminin: a good prognostic factor in high-grade astrocytic brain tumors, Cancer, 109巻, 5号, pp. 949-956, 20070129
    DOIを用いた論文検索結果へのリンク
  67. Survivin subcellular localization in high-grade astrocytomas: simultaneous expression in both nucleus and cytoplasm is negative prognostic marker, Journal of Neuro-Oncology, 82巻, 2号, pp. 193-198, 20061207
    DOIを用いた論文検索結果へのリンク
  68. Post-stroke affective or apathetic depression and lesion location: left frontal lobe and bilateral basal ganglia, European Archives of Psychiatry and Clinical Neuroscience, 257巻, 3号, pp. 149-152, 20061125
    DOIを用いた論文検索結果へのリンク
  69. Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas, Journal of Neuro-Oncology, 77巻, 3号, pp. 273-277, 20060414
    DOIを用いた論文検索結果へのリンク
  70. Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas, ANTICANCER RESEARCH, 26巻, 2B号, pp. 1351-1357, 20060301
  71. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome, American Journal of Medical Genetics - Part A, 140巻, 4号, pp. 358-367, 20060112
    DOIを用いた論文検索結果へのリンク
  72. Detection and differentiation of lactate and lipids by single-voxel proton MR spectroscopy, Neurosurgical Review, 28巻, 4号, pp. 267-277, 20050818
    DOIを用いた論文検索結果へのリンク
  73. Malnutrition and nonthyroidal illness syndrome after stroke, Metabolism, 54巻, 6号, pp. 699-704, 20050521
    DOIを用いた論文検索結果へのリンク
  74. ★, p16 Gene transfer increases cell killing with abnormal nucleation after ionising radiation in glioma cells, British Journal of Cancer, 89巻, 9号, pp. 1802-1811, 20031028
    DOIを用いた論文検索結果へのリンク
  75. Staurosporine-induced apoptosis is independent of p16 and p21 and achieved via arrest at G2/M and at G1 in U251MG human glioma cell line, Cancer Chemotherapy and Pharmacology, 51巻, 4号, pp. 271-283, 20030320
    DOIを用いた論文検索結果へのリンク
  76. Expression of survivin in astrocytic tumors: correlation with malignant grade and prognosis, Cancer, 97巻, 4号, pp. 1077-1083, 20030203
    DOIを用いた論文検索結果へのリンク
  77. Growth hormone receptor expression in brain tumors, Hiroshima Journal of Medical Sciences, 61巻, 1号, pp. 1-6, 201203
  78. Apparent diffusion coefficient of human brain tumors at MR imaging, Radiology, 235巻, 3号, pp. 985-991, 200506
    DOIを用いた論文検索結果へのリンク
  79. Relationship between intratumoral hemorrhage and overexpression of vascular endothelial growth factor (VEGF) in pituitary adenoma, Hiroshima Journal of Medical Sciences, 53巻, 2号, pp. 23-27, 200406
  80. Supra-diaphragmatic pituitary adenoma removed through the trans-tuberculum sellae approach. Case report., Neurologia medico-chirurgica, 52巻, 2号, pp. 91-95, 2012

招待講演、口頭・ポスター発表等

  1. iPad版Trail making testを用いた高次脳機能スクリーニングテストへの応用可能性, 濱 聖司, 柳川 亜紀子, 第８回　日本リハビリテーション医学会秋季学術集会, 2024年11月03日, 通常, 日本語, 日本リハビリテーション医学会, 岡山, 【目的】iPadを用いてデジタル化したTrail making test (iTMT)が、簡易的な認知機能スクリーニングテストに応用できるかどうかについて、Mini-mental state examination (MMSE)の推定を通して検討した。【方法】リハビリテーション目的で入院している患者42人（30人は脳卒中)を対象に、iTMTを5回(最初の3回:iTMT-A、4回目:TMT-Aの紙版、5回目:iTMT-Aの逆バージョン)、MMSEを1回実施した。各iTMT-Aの遂行時間は、移動時間と滞留時間に分けた。繰り返し効果は５回の遂行時間を線形混合モデルで解析。MMSEスコアの推定は３回のiTMT-AとiTMT-Bの遂行時間、あるいは3回のiTMT-Aの滞留時間、移動時間とiTMT-B可否を変数として偏最小二乗(PLS) 回帰で行った。【結果】線形混合モデルでは、3番目と4番目のiTMT-Aの遂行時間が最初のiTMT-Aよりも早いことから、学習効果が示唆された。PLS回帰では、MMSEスコアが低い被験者に対しても、iTMT-Aの繰り返しから抽出した滞留時間と移動時間、TMT-Bの可否を用いることで、iTMT-A & Bの遂行時間のみを使う解析（R2=0.45）よりもMMSEスコアを推定するための決定係数を高めた（R2=0.72）。これらの知見は、iTMT-Aの滞留時間が認知機能の推定に重要であることを示唆する。iTMT-Aは、時間的・空間的に多くの因子を抽出し、繰り返し試行の学習効果を取り入れることで、少ない試技で多くの脳機能をスクリーニングできる可能性が示せた。

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業(基盤研究(C)), 中性子捕捉療法のホウ素担体としての標的アデノウイルスベクターの確立, 2014年, 2017年