SEIJI HAMA

Last Updated :2025/08/07

Affiliations, Positions
Center for Brain, Mind and KANSEI Sciences Research, Associate Professor (Special Appointment)
E-mail
shamahiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Neurosurgery
  • Complex systems;Biomedical engineering;Rehabilitation science / Welfare engineering

Affiliated Academic Societies

Research Activities

Academic Papers

  1. Cognitive screening test for rehabilitation using spatiotemporal data extracted from a digital trail making test part-A, HELIYON, 10(13), 20240715
    Link to Paper Search Results by DOI
  2. Motor-cognitive functions required for driving in post-stroke individuals identified via machine-learning analysis, Journal of NeuroEngineering and Rehabilitation, 20(1), 139, 20231018
  3. Artificially-reconstructed brain images with stroke lesions from non-imaging data: modeling in categorized patients based on lesion occurrence and sparsity, Scientific Reports, 12, 10116, 20220616
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  4. Projection of Damaged Visual and Language Regions on Low Trail Making Test Part-B Performance in Stroke Patients, Frontiers in Neurology, 13, 853942, 20220602
  5. Increased cerebrovascular reactivity in selected brain regions after extracranial-intracranial bypass improves the speed and accuracy of visual cancellation in patients with severe steno-occlusive disease: a preliminary study, Neurosurgical Review, 45(3), 2257-2268, 20220130
    Link to Paper Search Results by DOI
  6. Lesions in the right Rolandic operculum are associated with self-rating affective and apathetic depressive symptoms for post-stroke patients, Scientific Reports, 10(1), 20264, 20201120
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  7. Relationships between motor and cognitive functions and subsequent post-stroke mood disorders revealed by machine learning analysis, Scientific Reports, 10(1), 19571, 20201111
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  8. Cerebrospinal fluid ctDNA and metabolites are informative biomarkers for the evaluation of CNS germ cell tumors, Scientific Reports, 10(1), 14326, 20200831
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  9. The right hemisphere is important for driving-related cognitive function after stroke, Neurosurgical Review, 44(2), 977-985, 20200311
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  10. Prognostic importance of temozolomide-induced neutropenia in glioblastoma, IDH-wildtype patients, Neurosurgical Review, 41(2), 621-628, 20170909
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  11. High Expression of Glypican-1 Predicts Dissemination and Poor Prognosis in Glioblastomas, World Neurosurgery, 105, 282-288, 20170824
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  12. Predicting ischemic stroke after carotid artery stenting based on proximal calcification and the jellyfish sign, Journal of Neurosurgery, 128(5), 1280-1288, 20170707
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  13. Neuroanatomic pathways associated with monoaminergic dysregulation after stroke, International Journal of Geriatric Psychiatry, 32(6), 633-642, 20170511
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  14. Effect of Gonadotropin and Adrenocorticotropic Hormone Secretion on Invasiveness of Clinically Nonfunctioning Pituitary Adenomas: A Cell Culture Study, World Neurosurgery, 96, 578-584, 20160904
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  15. p16 Gene Transfer Induces Centrosome Amplification and Abnormal Nucleation Associated with Survivin Downregulation in Glioma Cells, Pathobiology, 82(1), 1-8, 20150228
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  16. Effect of post-trochanteric groove support on stance control associated with the pelvic-lumbar system: A preliminary study, Prosthetics and Orthotics International, 39(5), 405-413, 20140612
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  17. Neuroanatomic pathway associated with attentional deficits after stroke, Brain Research, 1544, 25-32, 20131207
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  18. Neuroanatomic pathways associated with poststroke affective and apathetic depression, The American Journal of Geriatric Psychiatry, 21(9), 840-847, 20130206
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  19. Carotid arterial intraplaque hemorrhage and calcification influences cerebral hemodynamics, Neurosurgical Review, 36(3), 421-427, 20121214
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  20. Growth hormone receptor expression in brain tumors, Hiroshima Journal of Medical Sciences, 61(1), 1-6, 201203
  21. Supra-diaphragmatic pituitary adenoma removed through the trans-tuberculum sellae approach. Case report., Neurologia medico-chirurgica, 52(2), 91-95, 2012
  22. Masked hyperprolactinemia: tumor-derived factors inhibiting prolactin secretion caused by pituitary-stalk damage, Journal of Clinical Neuroscience, 18(12), 1651-1655, 20111019
    Link to Paper Search Results by DOI
  23. Post-operative hyponatremia in patients with pituitary adenoma: post-operative management with a uniform treatment protocol, Endocrine Journal, 58(5), 373-379, 20110405
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  24. Post-stroke depression and apathy: Interactions between functional recovery, lesion location, and emotional response, Psychogeriatrics, 11(1), 68-76, 20110330
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  25. Vulnerable carotid arterial plaque causing repeated ischemic stroke can be detected with B-mode ultrasonography as a mobile component: Jellyfish sign, Neurosurgical Review, 33(4), 419-430, 20100619
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  26. The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma, Anticancer Research, 29(2), 597-603, 20090201
  27. 'Insistence on recovery' as a positive prognostic factor in Japanese stroke patients, Psychiatry and Clinical Neurosciences, 62(4), 386-395, 20080731
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  28. Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells, British Journal of Cancer, 98(2), 345-355, 20080115
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  29. Sitting balance as an early predictor of functional improvement in association with depressive symptoms in stroke patients, Psychiatry and Clinical Neurosciences, 61(5), 543-551, 20070914
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  30. Depression or apathy and functional recovery after stroke, International Journal of Geriatric Psychiatry, 22(10), 1046-1051, 20070814
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  31. Retinoblastoma protein prevents staurosporine-induced cell death in a retinoblastoma-defective human glioma cell line, Pathobiology, 74(1), 22-31, 20070521
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  32. Geminin: a good prognostic factor in high-grade astrocytic brain tumors, Cancer, 109(5), 949-956, 20070129
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  33. Survivin subcellular localization in high-grade astrocytomas: simultaneous expression in both nucleus and cytoplasm is negative prognostic marker, Journal of Neuro-Oncology, 82(2), 193-198, 20061207
    Link to Paper Search Results by DOI
  34. Post-stroke affective or apathetic depression and lesion location: left frontal lobe and bilateral basal ganglia, European Archives of Psychiatry and Clinical Neuroscience, 257(3), 149-152, 20061125
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  35. Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas, Journal of Neuro-Oncology, 77(3), 273-277, 20060414
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  36. Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas, ANTICANCER RESEARCH, 26(2B), 1351-1357, 20060301
  37. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome, American Journal of Medical Genetics - Part A, 140(4), 358-367, 20060112
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  38. Detection and differentiation of lactate and lipids by single-voxel proton MR spectroscopy, Neurosurgical Review, 28(4), 267-277, 20050818
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  39. Malnutrition and nonthyroidal illness syndrome after stroke, Metabolism, 54(6), 699-704, 20050521
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  40. Apparent diffusion coefficient of human brain tumors at MR imaging, Radiology, 235(3), 985-991, 200506
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  41. Relationship between intratumoral hemorrhage and overexpression of vascular endothelial growth factor (VEGF) in pituitary adenoma, Hiroshima Journal of Medical Sciences, 53(2), 23-27, 200406
  42. ★, p16 Gene transfer increases cell killing with abnormal nucleation after ionising radiation in glioma cells, British Journal of Cancer, 89(9), 1802-1811, 20031028
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  43. Staurosporine-induced apoptosis is independent of p16 and p21 and achieved via arrest at G2/M and at G1 in U251MG human glioma cell line, Cancer Chemotherapy and Pharmacology, 51(4), 271-283, 20030320
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  44. Expression of survivin in astrocytic tumors: correlation with malignant grade and prognosis, Cancer, 97(4), 1077-1083, 20030203
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  45. Preparation of purified, sterilized, and stable adenovirus vectors using albumin, Journal of Virological Methods, 103(2), 191-199, 20020306
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  46. Overcoming multi-drug resistance using an intracellular anti-MDR1 sFv., International Journal of Cancer, 92(1), 115-122, 20010401
  47. Adenovirus-mediated p16 gene transfer changes the sensitivity to taxanes and Vinca alkaloids of human ovarian cancer cells, ANTICANCER RESEARCH, 21(4A), 2537-2545, 2001
  48. ★, Changes in the epithelium of Rathke cleft cyst associated with inflammation, Journal of Neurosurgery, 96(2), 209-216, 20010925
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  49. Peritumoral brain edema associated with meningioma: influence of vascular endothelial growth factor expression and vascular blood supply, Cancer, 85(4), 936-944, 20001119
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  50. Absence of mutations in the NBS1 gene in B-cell malignant lymphoma patients, ANTICANCER RESEARCH, 20(3B), 1897-1900, 2000
  51. Recurrence of meningiomas, Cancer, 89(5), 1102-1110, 20001113
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  52. Symptomatic Rathke's cleft cyst coexisting with central diabetes insipidus and hypophysitis: case report, Endocrine Journal, 46(1), 187-192, 1999
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  53. Size-adjustable titanium plate for reconstruction of the sella turcica. Technical note, Journal of Neurosurgery, 91(6), 1055-1057, 199912
    Link to Paper Search Results by DOI
  54. Transformation of rat glioma cells with the M-CSF gene inhibits tumorigenesis in vivo, Journal of Neuro-Oncology, 40(3), 197-204, 199812
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  55. ★, Adenovirus-mediated p16 gene transfer prevents drug-induced cell death through G1 arrest in human glioma cells, International Journal of Cancer, 77(1), 47-54, 19980703
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  56. High concentrations of recombinant adenovirus expressing p16 gene induces apoptosis in lung cancer cell lines, ANTICANCER RESEARCH, 18(6A), 4275-4282, 1998
  57. Genetic immunotherapy by intrapleural, intraperitoneal and subcutaneous injection of IL-2 gene-modified Lewis lung carcinoma cells, International Journal of Cancer, 73(6), 844-849, 19971210
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  58. Transformation of human glioma cell lines with the p16 gene inhibits cell proliferation, ANTICANCER RESEARCH, 17(3C), 1933-1938, 1997
  59. Parasellar chronic inflammatory disease presenting Tolosa-Hunt syndrome, hypopituitarism and diabetes insipidus: a case report, Endocrine Journal, 43(5), 503-510, 199610
    Link to Paper Search Results by DOI
  60. Pen-point Trajectory Analysis during Trail Making Test Based on a Time Base Generator Model, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS, 2021-January, 6215-6219, 20210101
  61. Vertical dynamic visual acuity is significantly lower than horizontal dynamic visual acuity, Scientific Reports, 13(1), 20231201

Invited Lecture, Oral Presentation, Poster Presentation

  1. Cognitive screening test for rehabilitation using spatiotemporal data extracted from a digital trail making test part-A, Seiji Hama, Akiko Yanagawa, 2024/11/03, Without Invitation, Japanese, Japanese Association of Rehabilitation Medicine

Patented

  1. Patent, 11744486, 2023/09/05
  2. Patent, 7181533, 2022/11/22
  3. Patent, 7250279, 2023/03/24
  4. 5561688, 2014/06/20

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2014, 2017
  2. KAKENHI, 2015, 2018
  3. Adaptable and Seamless Technology transfer Program through targetdriven R&D(A-STEP), 2022//1/0/, 2025//3//3
  4. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2023, 2025
  5. Adaptable and Seamless Technology transfer Program through targetdriven R&D(A-STEP), 2024//1//1, 2025//3//3