有井 潤Jun Arii

Last Updated :2026/06/29

所属・職名
大学院医系科学研究科（医）　教授
メールアドレス
jariihiroshima-u.ac.jp

基本情報

学位

  • 獣医学博士　(東京大学)
  • 博士（獣医学）　(東京大学)

研究分野

  • 農学 / 動物生命科学 / 獣医学
  • 医歯薬学 / 基礎医学 / 医化学一般
  • 医歯薬学 / 基礎医学 / ウイルス学
  • 生物学 / 生物科学 / 細胞生物学

研究キーワード

  • 微生物
  • ウイルス
  • ウイルス、ウイルス病態発現機構、自然免疫、抗ウイルス因子、ワクチン、抗ウイルス薬

研究活動

学術論文（★は代表的な論文）

  1. Conserved U14-Mediated NF-κB Activation in Human Herpesvirus 6A and 6B., Microbiology and immunology, 20260421
  2. ESCRT-III is recruited by human herpesvirus 6A nuclear egress complex to promote nuclear egress of the nucleocapsid., Journal of virology, pp. e0084425, 20250819
  3. Comparative Analysis of the Nuclear Egress Complex in Human Herpesvirus 6A and 6B., Microbiology and immunology, 69巻, 10号, pp. 502-510, 20250727
  4. HHV-6B ribonucleotide reductase sequesters NF-κB subunit p65 to inhibit innate immune responses, iScience, 28巻, 2号, 20250221
  5. ESCRT-III-dependent and -independent egress of herpesviruses, Frontiers in Virology, 4巻, 202403
  6. Human herpesvirus 6A nuclear matrix protein U37 interacts with heat shock transcription factor 1 and activates the heat shock response., Journal of virology, 97巻, 9号, pp. e0071823, 20230928
  7. Fourth mRNA vaccination increases cross-neutralizing antibody titers against SARS-CoV-2 variants, including BQ.1.1 and XBB, in a very elderly population., Journal of infection and public health, 16巻, 7号, pp. 1064-1072, 202307
  8. Identification and Analysis of Monoclonal Antibodies with Neutralizing Activity against Diverse SARS-CoV-2 Variants., Journal of virology, pp. e0028623, 20230516
  9. The Number of Coronavirus Disease 2019 Vaccine Doses and Severe Clinical Outcomes in Older Patients Infected With a Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant., The Journal of infectious diseases, 226巻, 11号, pp. 2041-2042, 20221128
  10. ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction., Journal of virology, 96巻, 19号, pp. e0126422, 20221012
  11. Cross-Neutralizing Activity Against Omicron Could Be Obtained in SARS-CoV-2 Convalescent Patients Who Received Two Doses of mRNA Vaccination, The Journal of Infectious Diseases, 226巻, 8号, pp. 1391-1395, 20220505
  12. Assessment of Neutralizing Antibody Response Against SARS-CoV-2 Variants After 2 to 3 Doses of the BNT162b2 mRNA COVID-19 Vaccine., JAMA network open, 5巻, 5号, pp. e2210780, 20220502
  13. Induction of High Neutralizing Activity Against Both Omicron BA.2 and Omicron BA.1 by Coronavirus Disease 2019 Messenger RNA Booster Vaccination, The Journal of Infectious Diseases, 226巻, 8号, pp. 1481-1483, 20220428
  14. Role of the Orphan Transporter SLC35E1 in the Nuclear Egress of Herpes Simplex Virus 1., Journal of virology, 96巻, 10号, pp. e0030622, 20220427
  15. Role of the Arginine Cluster in the Disordered Domain of Herpes Simplex Virus 1 UL34 for the Recruitment of ESCRT-III for Viral Primary Envelopment, Journal of Virology, 96巻, 2号, pp. e0170421., 20220126
  16. Cross-Neutralizing Breadth and Longevity Against SARS-CoV-2 Variants After Infections., Frontiers in immunology, 13巻, pp. 773652-773652, 2022
  17. Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron's outbreak., PloS one, 17巻, 4号, pp. e0266270, 2022
  18. Human Herpesvirus 6A Tegument Protein U14 Induces NF-κB Signaling by Interacting with p65, Journal of Virology, 95巻, 23号, 20211109
  19. Cross-Neutralizing Activity Against SARS-CoV-2 Variants in COVID-19 Patients: Comparison of 4 Waves of the Pandemic in Japan., Open forum infectious diseases, 8巻, 10号, pp. ofab430, 202110
  20. Host and Viral Factors Involved in Nuclear Egress of Herpes Simplex Virus 1., Viruses, 13巻, 5号, 20210425
  21. The Combination of gQ1 and gQ2 in Human Herpesvirus 6A and 6B Regulates the Viral Tetramer Function for Their Receptor Recognition, Journal of Virology, 95巻, 5号, 20210210
  22. The Neutralizing Antibody Response against Severe Acute Respiratory Syndrome Coronavirus 2 and the Cytokine/Chemokine Release in Patients with Different Levels of Coronavirus Diseases 2019 Severity: Cytokine Storm Still Persists Despite Viral Disappearance in Critical Patients., JMA journal, 4巻, 1号, pp. 1-7, 20210129
  23. Seroepidemiological Survey of the Antibody for Severe Acute Respiratory Syndrome Coronavirus 2 with Neutralizing Activity at Hospitals: A Cross-sectional Study in Hyogo Prefecture, Japan., JMA journal, 4巻, 1号, pp. 41-49, 20210129
  24. Early differences in cytokine production distinguish severity of COVID-19., The Journal of infectious diseases, 223巻, 7号, pp. 1145-1149, 20210107
  25. Prohibitin-1 Contributes to the Cell-to-Cell Transmission of Herpes Simplex Virus 1., Journal of virology, 95巻, 3号, 20201111
  26. ESCRT-III controls nuclear envelope deformation induced by progerin., Scientific reports, 10巻, 1号, pp. 18877-18877, 20201102
  27. Role of phosphatidyl-ethanolamine biosynthesis in herpes simplex virus 1 infected cells on progeny virus morphogenesis in the cytoplasm and on viral pathogenicity in vivo., Journal of virology, 94巻, 24号, 20200930
  28. Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics., Nature communications, 11巻, 1号, pp. 4894-4894, 20200929
  29. Human herpesvirus 6A U27 plays an essential role for the virus propagation., Microbiology and immunology, 64巻, 10号, pp. 703-711, 20200822
  30. Diligent Medical Activities of a Publicly Designated Medical Institution for Infectious Diseases Pave the Way for Overcoming COVID-19: A Positive Message to People Working at the Cutting Edge, Clinical Infectious Diseases, 72巻, 4号, pp. 723-724, 20200531
  31. Identification of the Capsid Binding Site in the Herpes Simplex Virus 1 Nuclear Egress Complex and Its Role in Viral Primary Envelopment and Replication., Journal of virology, 93巻, 21号, 20191101
  32. Roles of the Interhexamer Contact Site for Hexagonal Lattice Formation of the Herpes Simplex Virus 1 Nuclear Egress Complex in Viral Primary Envelopment and Replication., Journal of virology, 93巻, 14号, 20190715
  33. [Molecular mechanisms of entry and egress of herpes simplex virus 1]., Uirusu, 69巻, 1号, pp. 73-82, 2019
  34. Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis., Nature immunology, 19巻, 10号, pp. 1071-1082, 201810
  35. Roles of the Phosphorylation of Herpes Simplex Virus 1 UL51 at a Specific Site in Viral Replication and Pathogenicity., Journal of virology, 92巻, 18号, 20180915
  36. Regulation of Herpes Simplex Virus 2 Protein Kinase UL13 by Phosphorylation and Its Role in Viral Pathogenesis., Journal of virology, 92巻, 17号, 20180901
  37. ★, ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity., Nature communications, 9巻, 1号, pp. 3379-3379, 20180823
  38. Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication., Cell host & microbe, 23巻, 2号, pp. 254-265, 20180214
  39. The Role of HSV Glycoproteins in Mediating Cell Entry., Advances in experimental medicine and biology, 1045巻, pp. 3-21, 2018
  40. Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis., The Journal of clinical investigation, 127巻, 10号, pp. 3784-3795, 20171002
  41. Herpes Simplex Virus 1 Small Capsomere-Interacting Protein VP26 Regulates Nucleocapsid Maturation., Journal of virology, 91巻, 18号, 20170915
  42. Herpes Simplex Virus 1 UL34 Protein Regulates the Global Architecture of the Endoplasmic Reticulum in Infected Cells., Journal of virology, 91巻, 12号, 20170615
  43. Multiple Roles of the Cytoplasmic Domain of Herpes Simplex Virus 1 Envelope Glycoprotein D in Infected Cells., Journal of virology, 90巻, 22号, pp. 10170-10181, 20161115
  44. The Interaction between Herpes Simplex Virus 1 Tegument Proteins UL51 and UL14 and Its Role in Virion Morphogenesis., Journal of virology, 90巻, 19号, pp. 8754-67, 20161001
  45. p53 Is a Host Cell Regulator during Herpes Simplex Encephalitis., Journal of virology, 90巻, 15号, pp. 6738-6745, 20160801
  46. Roles of Us8A and Its Phosphorylation Mediated by Us3 in Herpes Simplex Virus 1 Pathogenesis., Journal of virology, 90巻, 12号, pp. 5622-5635, 20160615
  47. Ubiquitin-specific protease 9X in host cells interacts with herpes simplex virus 1 ICP0., The Journal of veterinary medical science, 78巻, 3号, pp. 405-10, 201603
  48. Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication., Journal of virology, 90巻, 6号, pp. 3173-86, 20160106
  49. Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene., Journal of virology, 90巻, 1号, pp. 457-73, 20160101
  50. Rapid Screening by Cell-Based Fusion Assay for Identifying Novel Antivirals of Glycoprotein B-Mediated Herpes Simplex Virus Type 1 Infection., Biological & pharmaceutical bulletin, 39巻, 11号, pp. 1897-1902, 2016
  51. Role of Host Cell p32 in Herpes Simplex Virus 1 De-Envelopment during Viral Nuclear Egress., Journal of virology, 89巻, 17号, pp. 8982-98, 201509
  52. Herpes Simplex Virus 1 Recruits CD98 Heavy Chain and β1 Integrin to the Nuclear Membrane for Viral De-Envelopment, Journal of Virology, 89巻, 15号, pp. 7799-7812, 201508
  53. Interactome analysis of herpes simplex virus 1 envelope glycoprotein H., Microbiology and immunology, 59巻, 6号, pp. 331-7, 201506
  54. Function of the Herpes Simplex Virus 1 Small Capsid Protein VP26 Is Regulated by Phosphorylation at a Specific Site., Journal of virology, 89巻, 11号, pp. 6141-7, 201506
  55. Nonmuscle myosin heavy chain IIb mediates herpes simplex virus 1 entry., Journal of virology, 89巻, 3号, pp. 1879-88, 201502
  56. Angiomotin functions in HIV-1 assembly and budding., eLife, 4巻, 20150129
  57. Phosphorylation of herpes simplex virus 1 dUTPase regulates viral virulence and genome integrity by compensating for low cellular dUTPase activity in the central nervous system., Journal of virology, 89巻, 1号, pp. 241-8, 201501
  58. The UL12 protein of herpes simplex virus 1 is regulated by tyrosine phosphorylation., Journal of virology, 88巻, 18号, pp. 10624-34, 201409
  59. Role of herpes simplex virus 1 immediate early protein ICP22 in viral nuclear egress., Journal of virology, 88巻, 13号, pp. 7445-54, 201407
  60. Phosphorylation of herpes simplex virus 1 dUTPase upregulated viral dUTPase activity to compensate for low cellular dUTPase activity for efficient viral replication., Journal of virology, 88巻, 14号, pp. 7776-85, 201407
  61. Herpes simplex virus 1 UL47 interacts with viral nuclear egress factors UL31, UL34, and Us3 and regulates viral nuclear egress., Journal of virology, 88巻, 9号, pp. 4657-67, 201405
  62. Role of the nuclease activities encoded by herpes simplex virus 1 UL12 in viral replication and neurovirulence., Journal of virology, 88巻, 4号, pp. 2359-64, 201402
  63. Role of herpes simplex virus 1 Us3 in viral neuroinvasiveness., Microbiology and immunology, 58巻, 1号, pp. 31-7, 201401
  64. Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells., PloS one, 8巻, 8号, pp. e72050, 2013
  65. Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport., The Journal of biological chemistry, 287巻, 52号, pp. 43910-26, 20121221
  66. Attenuated protein expression vectors for use in siRNA rescue experiments., BioTechniques, 0巻, 0号, pp. 1-5, 201208
  67. Herpes simplex virus 1 protein kinase Us3 and major tegument protein UL47 reciprocally regulate their subcellular localization in infected cells., Journal of virology, 85巻, 18号, pp. 9599-613, 201109
  68. Role of the herpes simplex virus 1 Us3 kinase phosphorylation site and endocytosis motifs in the intracellular transport and neurovirulence of envelope glycoprotein B., Journal of virology, 85巻, 10号, pp. 5003-15, 201105
  69. ★, Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1., Nature, 467巻, 7317号, pp. 859-62, 20101014
  70. A single-amino-acid substitution in herpes simplex virus 1 envelope glycoprotein B at a site required for binding to the paired immunoglobulin-like type 2 receptor alpha (PILRalpha) abrogates PILRalpha-dependent viral entry and reduces pathogenesis., Journal of virology, 84巻, 20号, pp. 10773-83, 201010
  71. Characterization of a thymidine kinase-deficient mutant of equine herpesvirus 4 and in vitro susceptibility of the virus to antiviral agents., Antiviral research, 85巻, 2号, pp. 389-95, 201002
  72. Effects of phosphorylation of herpes simplex virus 1 envelope glycoprotein B by Us3 kinase in vivo and in vitro., Journal of virology, 84巻, 1号, pp. 153-62, 201001
  73. Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor alpha depends on specific sialylated O-linked glycans on gB., Journal of virology, 83巻, 24号, pp. 13042-5, 200912
  74. Differences in the regulatory and functional effects of the Us3 protein kinase activities of herpes simplex virus 1 and 2., Journal of virology, 83巻, 22号, pp. 11624-34, 200911
  75. Analysis of herpesvirus host specificity determinants using herpesvirus genomes as bacterial artificial chromosomes., Microbiol Immunol., 53巻, 8号, pp. 433-41, 200908
  76. Entry of herpes simplex virus 1 and other alphaherpesviruses via the paired immunoglobulin-like type 2 receptor alpha., Journal of virology, 83巻, 9号, pp. 4520-7, 200905
  77. Identification of multiple sites suitable for insertion of foreign genes in herpes simplex virus genomes., Microbiology and immunology, 53巻, 3号, pp. 155-61, 200903
  78. Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface., Journal of virology, 83巻, 1号, pp. 250-61, 200901
  79. Cloning of the genome of equine herpesvirus 4 strain TH20p as an infectious bacterial artificial chromosome., Archives of virology, 154巻, 5号, pp. 833-42, 2009
  80. PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B., Cell, 132巻, 6号, pp. 935-44, 20080321
  81. Construction of an infectious clone of canine herpesvirus genome as a bacterial artificial chromosome., Microbes and infection, 8巻, 4号, pp. 1054-63, 200604
  82. ★, A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B, NATURE COMMUNICATIONS, 17巻, 1号, 20260501
    DOIを用いた論文検索結果へのリンク

招待講演、口頭・ポスター発表等

  1. ヘルペスウイルスによる宿主細胞改変の分子機構, 有井　潤, 第40回　中国四国ウイルス研究会, 2606年13月, 招待, 日本語
  2. ESCRT-IIIを利用するウイルス出芽と細胞小胞形成機構の比較, 有井 潤, 第98回日本生化学会大会 ・シンポジウム「細胞外分子放出を制御する細胞内システム」, 2025年11月04日, 招待, 日本語, 日本生化学会, 京都
  3. ヘルペスウイルスが誘導する細胞の再構築, 有井 潤, 東京大学・医科学研究所・学友会セミナー, 2025年08月08日, 招待, 日本語, 東京大学　医科学研究所
  4. ヘルペスウイルスによる宿主細胞の「改変」, 有井 潤, 京都大学医生物学研究所・「感染現象と医学・生命科学」研究会, 2025年01月27日, 招待, 日本語, 京都大学　医学生物学研究所
  5. ヘルペスウイルスと宿主応答との攻防, 有井 潤, 第38回日本エイズ学会学術集会・シンポジウム「免疫逃避」, 2024年11月29日, 招待, 日本語
  6. 抗ウイルス因子APOBEC3とヘルペスウイルスとの攻防, 有井 潤, 東京大学・医科学研究所・学友会セミナー, 2023年12月01日, 招待, 日本語
  7. ウイルス粒子形成に伴うオルガネラの再構築, 有井 潤, 第75回細胞生物学会大会・シンポジウム“「細胞外キャリア」の多様性とその形成機構”, 2023年06月29日
  8. ウイルス粒子形成の足場としての脂質の機能, 有井 潤, 第65回日本脂質生化学会・シンポジウム“生体膜脂質組成が規定するタンパク質動態・生理機能”, 2023年06月09日
  9. ヘルペスウイルス治療薬開発を目指したウイルス粒子形成機構の解析, 有井 潤, 第63回日本臨床ウイルス学会 日本ウイルス学会共催セミナー「ヘルペスウイルス感染症」, 2022年06月19日
  10. 単純ヘルペスウイルスによる核膜の再構築, 有井 潤; 川口寧, 第92回 日本生化学会シンポジウム・病原体と宿主が交差するオルガネラ・ゾーン, 2019年09月18日
  11. 単純ヘルペスウイルスによる核膜通過の分子機構, 有井 潤, 京都大学・ウイルス研究所・ウイルス研究の潮流シリーズセミナー, 2019年07月10日
  12. Molecular mechanisms of entry and egress of herpes simplex virus 1, 有井 潤, 第66回ウイルス学会 杉浦奨励賞特別講演, 2018年10月29日
  13. The interplay between HSV-1 and cellular membranes, Molecular Virology course in the institute of Virology, Freie Universität Berlin, 2017年07月27日
  14. 単純ヘルペスウイルスと宿主細胞膜との相互作用, 有井 潤, 第14回ウイルス学キャンプin湯河原, 2015年06月26日
  15. ラパトアセッション DNAウイルス, 有井 潤, 第62回ウイルス学会学術集会, 2014年11月12日
  16. 単純ヘルペスウイルスと宿主レセプターとの関わり, 有井 潤, 東京大学・医科学研究所 若手研究者シンポジウム「最先端基礎研究が開く新しい医療」, 2013年11月28日
  17. Non-Muscle Myosin Heavy Chain IIBは、HSV-1の侵入を仲介するco-receptorである, 有井 潤; 加藤哲久; 川口寧, 第61回ウイルス学会学術集会ミニシンポジウム「ウイルスエントリー」, 2013年11月12日
  18. AngiomotinはHIV出芽を促進する, 有井 潤, 理研セミナー, 2013年10月23日

受賞

  1. 2018年10月, 杉浦奨励賞受賞, 日本ウイルス学会
  2. 2017年04月, 科学技術分野の文部科学大臣表彰若手科学者賞, 文部科学省
  3. 2009年04月, 獣医学奨励賞, 日本獣医学会