JUN ARII

Last Updated :2026/07/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Professor

Basic Information

Academic Degrees

  • The University of Tokyo

Research Fields

  • Agricultural sciences;Animal life science;Veterinary medical science
  • Medicine,dentistry, and pharmacy;Basic medicine;General medical chemistry
  • Medicine,dentistry, and pharmacy;Basic medicine;Virology
  • Biology;Biological Science;Cell biology

Research Keywords

  • Viruses, viral pathogenesis, innate immunity, antiviral factors, vaccines, antiviral drugs
  • Microbiology
  • Virus

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, Intensive, Practice for medical research

Research Activities

Academic Papers

  1. ★, A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B, NATURE COMMUNICATIONS, 17(1), 20260501
    Link to Paper Search Results by DOI
  2. Conserved U14-Mediated NF-κB Activation in Human Herpesvirus 6A and 6B., Microbiology and immunology, 20260421
  3. ESCRT-III is recruited by human herpesvirus 6A nuclear egress complex to promote nuclear egress of the nucleocapsid., Journal of virology, e0084425, 20250819
  4. Comparative Analysis of the Nuclear Egress Complex in Human Herpesvirus 6A and 6B., Microbiology and immunology, 69(10), 502-510, 20250727
  5. HHV-6B ribonucleotide reductase sequesters NF-κB subunit p65 to inhibit innate immune responses, iScience, 28(2), 20250221
  6. ESCRT-III-dependent and -independent egress of herpesviruses, Frontiers in Virology, 4, 202403
  7. Human herpesvirus 6A nuclear matrix protein U37 interacts with heat shock transcription factor 1 and activates the heat shock response., Journal of virology, 97(9), e0071823, 20230928
  8. Fourth mRNA vaccination increases cross-neutralizing antibody titers against SARS-CoV-2 variants, including BQ.1.1 and XBB, in a very elderly population., Journal of infection and public health, 16(7), 1064-1072, 202307
  9. Identification and Analysis of Monoclonal Antibodies with Neutralizing Activity against Diverse SARS-CoV-2 Variants., Journal of virology, e0028623, 20230516
  10. The Number of Coronavirus Disease 2019 Vaccine Doses and Severe Clinical Outcomes in Older Patients Infected With a Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant., The Journal of infectious diseases, 226(11), 2041-2042, 20221128
  11. ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction., Journal of virology, 96(19), e0126422, 20221012
  12. Cross-Neutralizing Activity Against Omicron Could Be Obtained in SARS-CoV-2 Convalescent Patients Who Received Two Doses of mRNA Vaccination, The Journal of Infectious Diseases, 226(8), 1391-1395, 20220505
  13. Assessment of Neutralizing Antibody Response Against SARS-CoV-2 Variants After 2 to 3 Doses of the BNT162b2 mRNA COVID-19 Vaccine., JAMA network open, 5(5), e2210780, 20220502
  14. Induction of High Neutralizing Activity Against Both Omicron BA.2 and Omicron BA.1 by Coronavirus Disease 2019 Messenger RNA Booster Vaccination, The Journal of Infectious Diseases, 226(8), 1481-1483, 20220428
  15. Role of the Orphan Transporter SLC35E1 in the Nuclear Egress of Herpes Simplex Virus 1., Journal of virology, 96(10), e0030622, 20220427
  16. Role of the Arginine Cluster in the Disordered Domain of Herpes Simplex Virus 1 UL34 for the Recruitment of ESCRT-III for Viral Primary Envelopment, Journal of Virology, 96(2), e0170421., 20220126
  17. Cross-Neutralizing Breadth and Longevity Against SARS-CoV-2 Variants After Infections., Frontiers in immunology, 13, 773652-773652, 2022
  18. Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron's outbreak., PloS one, 17(4), e0266270, 2022
  19. Human Herpesvirus 6A Tegument Protein U14 Induces NF-κB Signaling by Interacting with p65, Journal of Virology, 95(23), 20211109
  20. Cross-Neutralizing Activity Against SARS-CoV-2 Variants in COVID-19 Patients: Comparison of 4 Waves of the Pandemic in Japan., Open forum infectious diseases, 8(10), ofab430, 202110
  21. Host and Viral Factors Involved in Nuclear Egress of Herpes Simplex Virus 1., Viruses, 13(5), 20210425
  22. The Combination of gQ1 and gQ2 in Human Herpesvirus 6A and 6B Regulates the Viral Tetramer Function for Their Receptor Recognition, Journal of Virology, 95(5), 20210210
  23. The Neutralizing Antibody Response against Severe Acute Respiratory Syndrome Coronavirus 2 and the Cytokine/Chemokine Release in Patients with Different Levels of Coronavirus Diseases 2019 Severity: Cytokine Storm Still Persists Despite Viral Disappearance in Critical Patients., JMA journal, 4(1), 1-7, 20210129
  24. Seroepidemiological Survey of the Antibody for Severe Acute Respiratory Syndrome Coronavirus 2 with Neutralizing Activity at Hospitals: A Cross-sectional Study in Hyogo Prefecture, Japan., JMA journal, 4(1), 41-49, 20210129
  25. Early differences in cytokine production distinguish severity of COVID-19., The Journal of infectious diseases, 223(7), 1145-1149, 20210107
  26. Prohibitin-1 Contributes to the Cell-to-Cell Transmission of Herpes Simplex Virus 1., Journal of virology, 95(3), 20201111
  27. ESCRT-III controls nuclear envelope deformation induced by progerin., Scientific reports, 10(1), 18877-18877, 20201102
  28. Role of phosphatidyl-ethanolamine biosynthesis in herpes simplex virus 1 infected cells on progeny virus morphogenesis in the cytoplasm and on viral pathogenicity in vivo., Journal of virology, 94(24), 20200930
  29. Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics., Nature communications, 11(1), 4894-4894, 20200929
  30. Human herpesvirus 6A U27 plays an essential role for the virus propagation., Microbiology and immunology, 64(10), 703-711, 20200822
  31. Diligent Medical Activities of a Publicly Designated Medical Institution for Infectious Diseases Pave the Way for Overcoming COVID-19: A Positive Message to People Working at the Cutting Edge, Clinical Infectious Diseases, 72(4), 723-724, 20200531
  32. Identification of the Capsid Binding Site in the Herpes Simplex Virus 1 Nuclear Egress Complex and Its Role in Viral Primary Envelopment and Replication., Journal of virology, 93(21), 20191101
  33. Roles of the Interhexamer Contact Site for Hexagonal Lattice Formation of the Herpes Simplex Virus 1 Nuclear Egress Complex in Viral Primary Envelopment and Replication., Journal of virology, 93(14), 20190715
  34. [Molecular mechanisms of entry and egress of herpes simplex virus 1]., Uirusu, 69(1), 73-82, 2019
  35. Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis., Nature immunology, 19(10), 1071-1082, 201810
  36. Roles of the Phosphorylation of Herpes Simplex Virus 1 UL51 at a Specific Site in Viral Replication and Pathogenicity., Journal of virology, 92(18), 20180915
  37. Regulation of Herpes Simplex Virus 2 Protein Kinase UL13 by Phosphorylation and Its Role in Viral Pathogenesis., Journal of virology, 92(17), 20180901
  38. ★, ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity., Nature communications, 9(1), 3379-3379, 20180823
  39. Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication., Cell host & microbe, 23(2), 254-265, 20180214
  40. The Role of HSV Glycoproteins in Mediating Cell Entry., Advances in experimental medicine and biology, 1045, 3-21, 2018
  41. Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis., The Journal of clinical investigation, 127(10), 3784-3795, 20171002
  42. Herpes Simplex Virus 1 Small Capsomere-Interacting Protein VP26 Regulates Nucleocapsid Maturation., Journal of virology, 91(18), 20170915
  43. Herpes Simplex Virus 1 UL34 Protein Regulates the Global Architecture of the Endoplasmic Reticulum in Infected Cells., Journal of virology, 91(12), 20170615
  44. Multiple Roles of the Cytoplasmic Domain of Herpes Simplex Virus 1 Envelope Glycoprotein D in Infected Cells., Journal of virology, 90(22), 10170-10181, 20161115
  45. The Interaction between Herpes Simplex Virus 1 Tegument Proteins UL51 and UL14 and Its Role in Virion Morphogenesis., Journal of virology, 90(19), 8754-67, 20161001
  46. p53 Is a Host Cell Regulator during Herpes Simplex Encephalitis., Journal of virology, 90(15), 6738-6745, 20160801
  47. Roles of Us8A and Its Phosphorylation Mediated by Us3 in Herpes Simplex Virus 1 Pathogenesis., Journal of virology, 90(12), 5622-5635, 20160615
  48. Ubiquitin-specific protease 9X in host cells interacts with herpes simplex virus 1 ICP0., The Journal of veterinary medical science, 78(3), 405-10, 201603
  49. Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication., Journal of virology, 90(6), 3173-86, 20160106
  50. Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene., Journal of virology, 90(1), 457-73, 20160101
  51. Rapid Screening by Cell-Based Fusion Assay for Identifying Novel Antivirals of Glycoprotein B-Mediated Herpes Simplex Virus Type 1 Infection., Biological & pharmaceutical bulletin, 39(11), 1897-1902, 2016
  52. Role of Host Cell p32 in Herpes Simplex Virus 1 De-Envelopment during Viral Nuclear Egress., Journal of virology, 89(17), 8982-98, 201509
  53. Herpes Simplex Virus 1 Recruits CD98 Heavy Chain and β1 Integrin to the Nuclear Membrane for Viral De-Envelopment, Journal of Virology, 89(15), 7799-7812, 201508
  54. Interactome analysis of herpes simplex virus 1 envelope glycoprotein H., Microbiology and immunology, 59(6), 331-7, 201506
  55. Function of the Herpes Simplex Virus 1 Small Capsid Protein VP26 Is Regulated by Phosphorylation at a Specific Site., Journal of virology, 89(11), 6141-7, 201506
  56. Nonmuscle myosin heavy chain IIb mediates herpes simplex virus 1 entry., Journal of virology, 89(3), 1879-88, 201502
  57. Angiomotin functions in HIV-1 assembly and budding., eLife, 4, 20150129
  58. Phosphorylation of herpes simplex virus 1 dUTPase regulates viral virulence and genome integrity by compensating for low cellular dUTPase activity in the central nervous system., Journal of virology, 89(1), 241-8, 201501
  59. The UL12 protein of herpes simplex virus 1 is regulated by tyrosine phosphorylation., Journal of virology, 88(18), 10624-34, 201409
  60. Role of herpes simplex virus 1 immediate early protein ICP22 in viral nuclear egress., Journal of virology, 88(13), 7445-54, 201407
  61. Phosphorylation of herpes simplex virus 1 dUTPase upregulated viral dUTPase activity to compensate for low cellular dUTPase activity for efficient viral replication., Journal of virology, 88(14), 7776-85, 201407
  62. Herpes simplex virus 1 UL47 interacts with viral nuclear egress factors UL31, UL34, and Us3 and regulates viral nuclear egress., Journal of virology, 88(9), 4657-67, 201405
  63. Role of the nuclease activities encoded by herpes simplex virus 1 UL12 in viral replication and neurovirulence., Journal of virology, 88(4), 2359-64, 201402
  64. Role of herpes simplex virus 1 Us3 in viral neuroinvasiveness., Microbiology and immunology, 58(1), 31-7, 201401
  65. Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells., PloS one, 8(8), e72050, 2013
  66. Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport., The Journal of biological chemistry, 287(52), 43910-26, 20121221
  67. Attenuated protein expression vectors for use in siRNA rescue experiments., BioTechniques, 0(0), 1-5, 201208
  68. Herpes simplex virus 1 protein kinase Us3 and major tegument protein UL47 reciprocally regulate their subcellular localization in infected cells., Journal of virology, 85(18), 9599-613, 201109
  69. Role of the herpes simplex virus 1 Us3 kinase phosphorylation site and endocytosis motifs in the intracellular transport and neurovirulence of envelope glycoprotein B., Journal of virology, 85(10), 5003-15, 201105
  70. ★, Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1., Nature, 467(7317), 859-62, 20101014
  71. A single-amino-acid substitution in herpes simplex virus 1 envelope glycoprotein B at a site required for binding to the paired immunoglobulin-like type 2 receptor alpha (PILRalpha) abrogates PILRalpha-dependent viral entry and reduces pathogenesis., Journal of virology, 84(20), 10773-83, 201010
  72. Characterization of a thymidine kinase-deficient mutant of equine herpesvirus 4 and in vitro susceptibility of the virus to antiviral agents., Antiviral research, 85(2), 389-95, 201002
  73. Effects of phosphorylation of herpes simplex virus 1 envelope glycoprotein B by Us3 kinase in vivo and in vitro., Journal of virology, 84(1), 153-62, 201001
  74. Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor alpha depends on specific sialylated O-linked glycans on gB., Journal of virology, 83(24), 13042-5, 200912
  75. Differences in the regulatory and functional effects of the Us3 protein kinase activities of herpes simplex virus 1 and 2., Journal of virology, 83(22), 11624-34, 200911
  76. Analysis of herpesvirus host specificity determinants using herpesvirus genomes as bacterial artificial chromosomes., Microbiol Immunol., 53(8), 433-41, 200908
  77. Entry of herpes simplex virus 1 and other alphaherpesviruses via the paired immunoglobulin-like type 2 receptor alpha., Journal of virology, 83(9), 4520-7, 200905
  78. Identification of multiple sites suitable for insertion of foreign genes in herpes simplex virus genomes., Microbiology and immunology, 53(3), 155-61, 200903
  79. Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface., Journal of virology, 83(1), 250-61, 200901
  80. Cloning of the genome of equine herpesvirus 4 strain TH20p as an infectious bacterial artificial chromosome., Archives of virology, 154(5), 833-42, 2009
  81. PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B., Cell, 132(6), 935-44, 20080321
  82. Construction of an infectious clone of canine herpesvirus genome as a bacterial artificial chromosome., Microbes and infection, 8(4), 1054-63, 200604