岸本 真治SHINJI KISHIMOTO

Last Updated :2021/09/04

所属・職名
原爆放射線医科学研究所 助教
メールアドレス
skishimotohiroshima-u.ac.jp
自己紹介
動脈硬化を中心に臨床、研究を行っています。特に高血圧(原因の明らかな2次性高血圧を含めて)を専門としております。

基本情報

学歴

  • 広島大学, 大学院医歯薬保健学研究科, 医歯薬学専攻 博士課程, 日本, 2014年01月, 2018年03月
  • 広島大学, 医学部, 医学科, 日本, 2003年04月, 2009年03月

学位

  • 博士(医学) (広島大学)

所属学会

  • 日本心血管インターベンション治療学会
  • 日本高血圧学会
  • 日本心臓病学会
  • 日本循環器学会
  • 日本内科学会

研究活動

学術論文(★は代表的な論文)

  1. Coronary angioscopic findings 9 months after everolimus-eluting stent implantation compared with sirolimus-eluting stents, Journal of Cardiology, 61巻, 1号, pp. 22-30, 201301
  2. Longitudinal extent of lipid pool assessed by optical coherence tomography predicts microvascular no-reflow after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction., Journal of Cardiology, 62巻, 2号, pp. 71-76, 201308
  3. Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current., Circulation Arrhythmia and Electrophysiology, 9巻, 1号, pp. e003436, 201601
  4. Combination of Flow-Mediated Vasodilation and Nitroglycerine-Induced Vasodilation Is More Effective for Prediction of Cardiovascular Events., Hypertension, 67巻, 5号, pp. 1045-1052, 201604
  5. Relationship between serum triglyceride levels and endothelial function in a large community-based study., Atherosclerosis, 247巻, pp. 70-75, 201606
  6. Vascular Function and Intima-media Thickness of a Leg Artery in Peripheral Artery Disease: A Comparison of Buerger Disease and Atherosclerotic Peripheral Artery Disease., Journal of Atherosclerosis and Thrombosis, 23巻, 11号, pp. 1261-1269, 201611
  7. Endothelial Function Assessed by Automatic Measurement of Enclosed Zone Flow-Mediated Vasodilation Using an Oscillometric Method Is an Independent Predictor of Cardiovascular Events., Journal of the American Heart Association, 5巻, 12号, pp. e004385, 201610
  8. Endothelial function is impaired in relation to alcohol intake even in the case of light alcohol consumption in Asian men; Flow-mediated Dilation Japan (FMD-J) Study., International Journal of Cardiology, 230巻, pp. 523-528, 201703
  9. Increasing Risk of Osteoporotic Fracture Is Associated With Vascular Dysfunction and Abnormal Vascular Structure in Both Men and Women., Circulation Journal, 81巻, 6号, pp. 786-787, 201705
  10. Decreased frequency and duration of tooth brushing is a risk factor for endothelial dysfunction., International Journal of Cardiology, 241巻, pp. 30-34, 201708
  11. Relation of the Bilateral Earlobe Crease to Endothelial Dysfunction., The American Journal of Cardiology, 119巻, 12号, pp. 1983-1988, 201706
  12. α-Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome: a multicenter randomized controlled (MACS) study., Cardiovasc Diabetol, 16巻, 1号, pp. 86, 201706
  13. Endothelial Function Is Impaired in Patients Receiving Antihypertensive Drug Treatment Regardless of Blood Pressure Level: FMD-J Study (Flow-Mediated Dilation Japan)., Hypertension, 70巻, 4号, pp. 790-797, 201710
  14. Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals., Scientific Reports, 7巻, 1号, pp. 8422, 201708
  15. Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study., Atherosclerosis, 268巻, pp. 92-98, 201801
  16. Interrelationships Among Flow-Mediated Vasodilation, Nitroglycerine-Induced Vasodilation, Baseline Brachial Artery Diameter, Hyperemic Shear Stress, and Cardiovascular Risk Factors., Journal of the American Heart Association, 7巻, 1号, pp. e006797, 201801
  17. Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension., European Journal of Nutrition, 201801
  18. Chronic kidney disease is associated with vascular smooth muscle dysfunction but not with endothelial dysfunction., International Journal of Cardiology, 254巻, pp. 284-290, 201803
  19. Reactive hyperemia-peripheral arterial tonometry is useful for assessment of not only endothelial function but also stenosis of the digital artery., International Journal of Cardiology Volume 260, 1 June 2018, Pages 178-183, 260巻, pp. 178-183, 201806
  20. Endothelial dysfunction, abnormal vascular structure and lower urinary tract symptoms in men and women., International Journal of Cardiology, 261巻, pp. 196-203, 201806
  21. New assessment of endothelial function measured by short time flow-mediated vasodilation: Comparison with conventional flow-mediated vasodilation measurement., International Journal of Cardiology, 265巻, pp. 24-29, 201808
  22. Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation., Scientific Reoports, 18巻, 1号, pp. 9263, 201806
  23. Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD-J (Flow-Mediated Dilation Japan) Study A., Journal of the American Heart Association, 7巻, 14号, pp. e008588, 201807
  24. Microvascular endothelial function is impaired in patients with idiopathic hyperaldosteronism., Hypertension Research, 201809
  25. Comparison of gender-specific mortality in patients < 70 years versus ≥ 70 years old with acute myocardial infarction., The American Journal of Cardiology, 108巻, 6号, pp. 772-775, 20110915
  26. Reduction in blood pressure improves impaired nitroglycerine-induced vasodilation in patients with essential hypertension., Hypertension Research, 38巻, 12号, pp. 862-868, 20150903
  27. Circulating level of pigment epithelium-derived factor is associated with vascular function and structure: A cross-sectional study., International Journal of Cardiology, 225巻, pp. 91-95, 20161015
  28. Nitroglycerine-induced vasodilation in coronary and brachial arteries in patients with suspected coronary artery disease., International Journal of Cardiology, 219巻, 15号, pp. 312-316, 20160915
  29. Endothelial dysfunction and abnormal vascular structure are simultaneously present in patients with heart failure with preserved ejection fraction, International Journal of Cardiology, 231巻, pp. 181-187, 201703
  30. Microvascular endothelial function is impaired in patients with idiopathic hyperaldosteronism, HYPERTENSION RESEARCH, 41巻, 11号, pp. 932-938, 201811
  31. Elevated Plasma Renin Activity Caused by Accelerated-malignant Hypertension in a Patient with Aldosterone-producing Adenoma Complicated with Renal Insufficiency, INTERNAL MEDICINE, 58巻, 21号, pp. 3107-3111, 2019
  32. Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease - Post Hoc Analysis of the FMD-J Study A, Circulation Journal, 83巻, 5号, pp. 1064-1071, 201904
  33. Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study, JOURNAL OF HYPERTENSION, 37巻, 5号, pp. 1083-1095, 201905
  34. Review of the Long-term Effects of Autologous Bone-Marrow Mononuclear Cell Implantation on Clinical Outcomes in Patients with Critical Limb Ischemia, SCIENTIFIC REPORTS, 9巻, 20190522
  35. Relationships Between Calcium Channel Blockers and Vascular Function Tests, AMERICAN JOURNAL OF HYPERTENSION, 32巻, 7号, pp. 640-648, 201907
  36. Effects of the Dipeptidyl Peptidase 4 Inhibitor Alogliptin on Blood Pressure in Hypertensive Patients with Type 2 Diabetes Mellitus, AMERICAN JOURNAL OF HYPERTENSION, 32巻, 7号, pp. 695-702, 201907
  37. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study, SCIENTIFIC REPORTS, 9巻, 20190715
  38. Relationship between home blood pressure and vascular function in patients receiving antihypertensive drug treatment, HYPERTENSION RESEARCH, 42巻, 8号, pp. 1175-1185, 201908
  39. Association of extremely high levels of high-density lipoprotein cholesterol with endothelial dysfunction in men, JOURNAL OF CLINICAL LIPIDOLOGY, 13巻, 4号, pp. 664-672, 201908
  40. Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 9巻, 2号, 20200121
  41. Long-Term Clinical Outcomes of Autologous Bone Marrow Mononuclear Cell Implantation in Patients With Severe Thromboangiitis Obliterans, CIRCULATION JOURNAL, 84巻, 4号, pp. 650-655, 202004
  42. Non-Invasive Central Venous Pressure Measurement Using Enclosed-Zone Central Venous Pressure (ezCVP (TM)), CIRCULATION JOURNAL, 84巻, 7号, pp. 1112-1117, 202007
  43. Hematocrit, hemoglobin and red blood cells are associated with vascular function and vascular structure in men, SCIENTIFIC REPORTS, 10巻, 1号, 20200710
  44. Increased arterial stiffness and cardiovascular risk prediction in controlled hypertensive patients with coronary artery disease: post hoc analysis of FMD-J (Flow-mediated Dilation Japan) Study A, HYPERTENSION RESEARCH, 43巻, 8号, pp. 781-790, 202008
  45. Vascular function is further impaired in subjects aged 80 years or older, HYPERTENSION RESEARCH, 43巻, 9号, pp. 914-921, 202009
  46. Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study, BMJ OPEN, 10巻, 7号, 2020
  47. Pre-impaired fasting glucose state is a risk factor for endothelial dysfunction: Flow-mediated Dilation Japan (FMD-J) study, BMJ OPEN DIABETES RESEARCH & CARE, 8巻, 1号, 2020
  48. Daily Low-intensity Pulsed Ultrasound Ameliorates Renal Fibrosis and Inflammation in Experimental Hypertensive and Diabetic Nephropathy, HYPERTENSION, 76巻, 6号, pp. 1906-1914, 202012
  49. A Comparison of Adrenalectomy and Eplerenone on Vascular Function in Patients with Aldosterone-producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 105巻, 11号, 202011
  50. Relationship between cell number and clinical outcomes of autologous bone-marrow mononuclear cell implantation in critical limb ischemia, SCIENTIFIC REPORTS, 10巻, 1号, 20201116
  51. Endothelial function is preserved in light to moderate alcohol drinkers but is impaired in heavy drinkers in women: Flow-mediated Dilation Japan (FMD-J) study, PLOS ONE, 15巻, 12号, 20201203
  52. Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy, JOURNAL OF CLINICAL MEDICINE, 9巻, 12号, 202012
  53. Association of Body Mass Index with Endothelial Function in Asian Men, INTERNATIONAL JOURNAL OF CARDIOLOGY, 324巻, pp. 186-192, 20210201
  54. Smoking status and endothelial function in Japanese men, SCIENTIFIC REPORTS, 11巻, 1号, 20210108
  55. Upstroke Time Is a Useful Vascular Marker for Detecting Patients With Coronary Artery Disease Among Subjects With Normal Ankle-Brachial Index, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 9巻, 23号, 20201201
  56. Finger blood flow after the cold challenge with primary Raynaud's syndrome: a case report, EUROPEAN HEART JOURNAL-CASE REPORTS, 4巻, 6号, 202012
  57. Lower triglyceride levels are associated with better endothelial function, JOURNAL OF CLINICAL LIPIDOLOGY, 15巻, 3号, pp. 500-511, 2021

著書等出版物

  1. 2020年, 循環器疾患とビッグデータ・AI 心不全とビッグデータ, 心不全とビッグデータ, 科学評論社, 2020年, 7/28, その他, 共著, 岸本真治、東幸仁

招待講演、口頭・ポスター発表等

  1. A Study to Compare the Effects of Adrenalectomy and Eplerenone on Vascular Function in Patients with Aldosterone-producing Adenoma, Shinji Kishimoto, Yukihito Higashi, Yu Hashimoto, Takahiro Harada, Takayuki Yamaji, Yuji Takaeko, Farina Mohamad Yusoff, Masato Kajikawa, Tatsuya Maruhashi, Yukiko Nakano, The 85th Annual Scientific Meeting of The Japanese Circulation Society : JCS 2021, 2021年03月26日, 通常, 英語
  2. 男性におけるヘマトクリットと 血管機能・血管構造との関係, 岸本真治 、橋本悠、溝渕亜矢、韓一鳴、山路貴之、原田崇弘、 Farina Mohamad Yusoff、梶川正人、丸橋達也、中野由紀子、東幸仁, 第74回日本酸化ストレス学会、第21回日本NO学会 合同学術集会, 2021年05月19日, 通常, 日本語
  3. Vascular Function and Vascular Structure are Impaired in Patients with Heart Failure with Preserved Ejection Fraction, Shinji Kishimoto, Yukihito Higashi, Nozomu Oda, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Yumiko Iwamoto, Tatsuya Maruhashi, Ayumu Nakashima, Takayuki Hidaka, Kensuke Noma, Yasuki Kihara, 88th Scientific Sessions, American Heart Association, 2015年11月08日, 通常, 英語, Orlando, Florida
  4. Paclitaxel-Coated Balloon (PCB)後にslow flowを認め、血管内視鏡を施行した2例, 岸本真治,池永寛樹,栗栖智,渡辺紀晶,下永貴司,檜垣忠直,岩崎年高,石橋堅,土肥由裕,福田幸弘,木原康樹, 第17回中四国血管内視鏡研究会, 2015年12月14日, 通常, 日本語
  5. Vascular Function and Vascular Structure are Impaired in Patients with Heart Failure with Preserved Ejection Fraction, Shinji Kishimoto, Yukihito Higashi, Nozomu Oda, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Yumiko Iwamoto, Tatsuya Maruhashi, Ayumu Nakashima, Takayuki Hidaka, Kensuke Noma, Yasuki Kihara, 第80回日本循環器病学会, 2016年03月19日, 通常, 英語
  6. 駆出率の保持された心不全(HFpEF)における血管内皮機能と血管構造, 岸本真治、丸橋達也、梶川正人、岩本明倫、小田望、野間玄督、木原康樹、東幸仁, 第1回日本血管不全学会学術集会, 2016年04月17日, 通常, 日本語
  7. Heart failure with preserved ejection fraction(HFpEF)における血管内皮機能低下と血管構造異常, 岸本真治、丸橋達也、梶川正人、岩本明倫、小田望、野間玄督、木原康樹、東幸仁, 東京, 2016年08月06日, 通常, 日本語
  8. Vascular Function and Rho-associated Kinase Activity in Patients with Idiopathic hyperaldosteronism, Shinji Kishimoto, Takeshi Matsumoto, Shogo matsui, Nozomu Oda, Masato Kajikawa, Yumiko Iwamoto, Tatsuya Maruhashi, Ayumu Nakashima, Takayuki Hidaka, Kensuke Noma, Yasuki Kihara Yukihito Higashi, The Pulse of Asia 2016, 2016年09月24日, 通常, 英語
  9. 2型糖尿病を合併した高血圧症患者におけるアログリプチンの有用性, 岸本真治、丸橋達也、梶川正人 、小田望 、松井翔吾、日高貴之 、野間玄督、木原康樹、東幸仁, 第39回日本高血圧学会, 2016年10月01日, 通常, 日本語
  10. Heart failure with preserved ejection fraction(HFpEF)における血管内皮機能と血管構造, 岸本真治 、東幸仁、松井翔吾 、小田望、梶川正人 、岩本由美子、丸橋達也 、日高貴之、野間玄督、木原康樹, 第20回 日本心不全学術集会, 2016年10月08日, 招待, 日本語
  11. 特発性アルドステロン症における血管内皮機能とRho-associated kinase活性について, 岸本真治、丸橋達也、梶川正人 、小田望 、松井翔吾、野間玄督、木原康樹、東幸仁, 第2回日本血管不全学会学術集会, 2017年04月16日, 通常, 日本語
  12. 血管機能障害・構造異常はHeart failure with preserved ejection fraction(HFpEF) の病因に成り得るか, 岸本真治 、東幸仁、橋本東樹、松井翔吾、梶川正人、岩本由美子、丸橋達也、日高貴之、野間玄督、木原康樹, 第110回 日本循環器病学会中国・四国合同地方会, 2017年06月30日, 通常, 日本語
  13. Patients with Diastolic Ventricular Dysfunction and Ventricular Hypertrophy may occur Heart Failure with Preserved Ejection Fraction through Endothelial Dysfunction, Shinji Kishimoto,Yukihito Higashi,Haruki Hashimoto, Shogo Matsui, Masato Kajikawa, Tatsuya Maruhashi, Farina Mohamad Yusoff, Takayuki Hidaka, Kensuke Noma, Yasuki Kihara, 第82回日本循環器病学会, 2018年03月24日, 通常, 英語
  14. エプレレノンによる特発性アルドステロン症の血管内皮機能への影響, 岸本真治、東幸仁、沖健司、高永甲有司、橋本東樹、松井翔吾、梶川正人、丸橋達也、野間玄督、木原康樹, 第62回広島高血圧・生活習慣病研究会, 2018年11月09日, 通常, 日本語
  15. エプレレノンによる特発性アルドステロン症の血管内皮機能と Rho-associated kinase活性への影響, 岸本真治 、沖健司、 Farina Mohamad Yusoff、高永甲有司、橋本東樹、松井翔吾、梶川正人、丸橋達也、野間玄督、木原康樹、東幸仁, 第15回脳心血管抗加齢研究会, 2018年12月14日, 通常, 日本語, 大阪
  16. Role of Resistin-like Molecule β in Akt/AMPK/Hsp90/eNOS Pathway, Shinji Kishimoto, Yasuki kihara, Yukihito Higashi, the 3rd international symposium of the network-type joint usage/research center for radiation disaster medical science, 2019年01月13日, 通常, 英語
  17. Eplerenone Improves Endothelial Function, Arterial Stiffness and Rho-associated Kinase Activity in Patients with Idiopathic Hyperaldosteronism, 第83回日本循環器学会学術集会, 2019年03月29日, 通常, 英語
  18. Patients with Diastolic Ventricular Hypertrophy and Ventricular Dysfunction may occur Heart Failure with Preserved Ejection Fraction through Endothelial Dysfunction, Shinji Kishimoto 、Yukihito Higashi、Takayuki Yamaji 、Takahiro Harada、Yuji Takaeko、Farina Mohamad Yusoff、Haruki Hashimoto、Masato Kajikawa、Tatsuya Maruhashi、Takayuki Hidaka、Yasuki Kihara, 第23回日本心不全学会学術集会, 2019年10月04日, 通常, 日本語
  19. Eplerenone Improves Vascular Function, Arterial Stiffness and Rho-associated Kinase Activity in Patients with Idiopathic Hyperaldosteronism, Shinji Kishimoto, Yukihito Higashi, Takayuki Yamaji, Takahiro Harada Yuji Takaeko, Farina Mohamad Yusoff, Haruki Hashimoto, Shogo Matsui, Masato Kajikawa, Tatsuya Maruhashi, Kensuke Noma, Yasuki Kihara , American Heart Association Scientific Session 2019, 2019年11月15日, 通常, 英語
  20. Role of Resistin-like Molecule β in Akt/AMPK/Hsp90/eNOS Pathway, Shinji Kishimoto, Takahiro Harada, Takayuki Yamaji, Yiming Han, Yuji Takaeko, Farina Mohamad Yusoff, Haruki Hashimoto, Masato Kajikawa, Tatsuya Maruhashi, Ayumu Nakashima, Yasuki Kihara, Yukihito Higashi, The 4th international symposium of the network-type joint usage/research center for radiation disaster medical science, 2020年02月12日, 通常, 英語

受賞

  1. 2021年05月20日, 第21回日本NO学会候補セッション 優秀賞, 日本NO学会理事長/第21回日本NO学会会長
  2. 2016年, Pulse of Asia 2016 Travel Grant, Pulse of Asia
  3. 2017年06月30日, 第110回日本循環器病学会中国四国合同地方会 若手研究者奨励賞, 日本循環器病学会
  4. 2018年, 第36回広仁会賞, 広仁会

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業(若手研究), 動脈硬化に関するレジスチン様分子の役割の解析, 2020年, 2022年

社会活動

委員会等委員歴

  1. 非常勤医師, 2021年04月, 2022年03月, 因島医師会病院