SHINJI KISHIMOTO

Last Updated :2024/06/05

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Assistant Professor
E-mail
skishimotohiroshima-u.ac.jp
Self-introduction
We have conducted medical treatment and research on atherosclerosis. My speciality is hypertension.

Basic Information

Educational Backgrounds

  • Hiroshima University, Graduate School of Biomedical & Health Sciences , Japan, 2014/01, 2018/03
  • Hiroshima University, Faculty of Medicine, Japan, 2003/04, 2009/03

Academic Degrees

  • PhD, Hiroshima University

Affiliated Academic Societies

  • Japanese Association of Cardiovascular intervention and Terapeutics
  • The Japanese Society of Hypertension
  • Japanese College of Cardiology
  • The Japanese Circulation Society
  • The Japanese Society of Internal Medicine

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Intensive, Practice for medical research

Research Activities

Academic Papers

  1. Endothelial Function Is Preserved in Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy, Journal of Clinical Medicine, 12(7), 2534, 20230327
  2. Effect of ipragliflozin on carotid intima-media thickness in patients with type 2 diabetes: a multicenter, randomized, controlled trial, European Heart Journal Cardiovascular Pharmacotherapy, 9(2), 165-172, 20230202
  3. Effect of exposure to radiation caused by an atomic bomb on endothelial function in atomic bomb survivors, FRONTIERS IN CARDIOVASCULAR MEDICINE, 10, 20230217
  4. The prevalence of cardiovascular disease is higher in patients with bilateral low ankle-brachial index than in patients with unilateral low ankle-brachial index, ATHEROSCLEROSIS, 360, 8-14, 202211
  5. Serum Potassium Levels of 4.5 to Less Than 5.0 mmol/L Are Associated with Better Vascular Function, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 29(11), 1588-1602, 2022
  6. Relationship of Daily Coffee Intake with Vascular Function in Patients with Hypertension, NUTRIENTS, 14(13), 202207
  7. White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation, SCIENTIFIC REPORTS, 12(1), 20220517
  8. Relationship between hemoglobin A1c level and flow-mediated vasodilation in patients with type 2 diabetes mellitus receiving antidiabetic drugs, JOURNAL OF DIABETES INVESTIGATION, 13(4), 677-686, 202204
  9. Self-reported total sitting time on a non-working day is associated with blunted flow-mediated vasodilation and blunted nitroglycerine-induced vasodilation, SCIENTIFIC REPORTS, 12(1), 20220416
  10. Implantation of Hypoxia-Induced Mesenchymal Stem Cell Advances Therapeutic Angiogenesis, STEM CELLS INTERNATIONAL, 2022, 20220320
  11. Isolated diastolic hypertension is not associated with endothelial dysfunction, HYPERTENSION RESEARCH, 45(4), 698-707, 202204
  12. Poor tooth brushing behavior is associated with high risk of cardiovascular events: A prospective observational study, INTERNATIONAL JOURNAL OF CARDIOLOGY, 350, 111-117, 20220301
  13. Inconvenient relationship of haemoglobin A1c level with endothelial function in type 2 diabetes in a cross-sectional study, BMJ OPEN, 11(6), 202106
  14. Comparison of gender-specific mortality in patients < 70 years versus ≥ 70 years old with acute myocardial infarction., The American Journal of Cardiology, 108(6), 772-775, 20110915
  15. Coronary angioscopic findings 9 months after everolimus-eluting stent implantation compared with sirolimus-eluting stents, Journal of Cardiology, 61(1), 22-30, 201301
  16. Longitudinal extent of lipid pool assessed by optical coherence tomography predicts microvascular no-reflow after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction., Journal of Cardiology, 62(2), 71-76, 201308
  17. Reduction in blood pressure improves impaired nitroglycerine-induced vasodilation in patients with essential hypertension., Hypertension Research, 38(12), 862-868, 20150903
  18. Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current., Circulation Arrhythmia and Electrophysiology, 9(1), e003436, 201601
  19. Combination of Flow-Mediated Vasodilation and Nitroglycerine-Induced Vasodilation Is More Effective for Prediction of Cardiovascular Events., Hypertension, 67(5), 1045-1052, 201604
  20. Relationship between serum triglyceride levels and endothelial function in a large community-based study., Atherosclerosis, 247, 70-75, 201606
  21. Nitroglycerine-induced vasodilation in coronary and brachial arteries in patients with suspected coronary artery disease., International Journal of Cardiology, 219(15), 312-316, 20160915
  22. Circulating level of pigment epithelium-derived factor is associated with vascular function and structure: A cross-sectional study., International Journal of Cardiology, 225, 91-95, 20161015
  23. Vascular Function and Intima-media Thickness of a Leg Artery in Peripheral Artery Disease: A Comparison of Buerger Disease and Atherosclerotic Peripheral Artery Disease., Journal of Atherosclerosis and Thrombosis, 23(11), 1261-1269, 201611
  24. Endothelial Function Assessed by Automatic Measurement of Enclosed Zone Flow-Mediated Vasodilation Using an Oscillometric Method Is an Independent Predictor of Cardiovascular Events., Journal of the American Heart Association, 5(12), e004385, 201610
  25. Endothelial function is impaired in relation to alcohol intake even in the case of light alcohol consumption in Asian men; Flow-mediated Dilation Japan (FMD-J) Study., International Journal of Cardiology, 230, 523-528, 201703
  26. Endothelial dysfunction and abnormal vascular structure are simultaneously present in patients with heart failure with preserved ejection fraction, International Journal of Cardiology, 231, 181-187, 201703
  27. Increasing Risk of Osteoporotic Fracture Is Associated With Vascular Dysfunction and Abnormal Vascular Structure in Both Men and Women., Circulation Journal, 81(6), 786-787, 201705
  28. Decreased frequency and duration of tooth brushing is a risk factor for endothelial dysfunction., International Journal of Cardiology, 241, 30-34, 201708
  29. Relation of the Bilateral Earlobe Crease to Endothelial Dysfunction., The American Journal of Cardiology, 119(12), 1983-1988, 201706
  30. α-Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome: a multicenter randomized controlled (MACS) study., Cardiovasc Diabetol, 16(1), 86, 201706
  31. Endothelial Function Is Impaired in Patients Receiving Antihypertensive Drug Treatment Regardless of Blood Pressure Level: FMD-J Study (Flow-Mediated Dilation Japan)., Hypertension, 70(4), 790-797, 201710
  32. Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals., Scientific Reports, 7(1), 8422, 201708
  33. Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study., Atherosclerosis, 268, 92-98, 201801
  34. Interrelationships Among Flow-Mediated Vasodilation, Nitroglycerine-Induced Vasodilation, Baseline Brachial Artery Diameter, Hyperemic Shear Stress, and Cardiovascular Risk Factors., Journal of the American Heart Association, 7(1), e006797, 201801
  35. Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension., European Journal of Nutrition, 201801
  36. Chronic kidney disease is associated with vascular smooth muscle dysfunction but not with endothelial dysfunction., International Journal of Cardiology, 254, 284-290, 201803
  37. Reactive hyperemia-peripheral arterial tonometry is useful for assessment of not only endothelial function but also stenosis of the digital artery., International Journal of Cardiology Volume 260, 1 June 2018, Pages 178-183, 260, 178-183, 201806
  38. Endothelial dysfunction, abnormal vascular structure and lower urinary tract symptoms in men and women., International Journal of Cardiology, 261, 196-203, 201806
  39. New assessment of endothelial function measured by short time flow-mediated vasodilation: Comparison with conventional flow-mediated vasodilation measurement., International Journal of Cardiology, 265, 24-29, 201808
  40. Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation., Scientific Reoports, 18(1), 9263, 201806
  41. Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD-J (Flow-Mediated Dilation Japan) Study A., Journal of the American Heart Association, 7(14), e008588, 201807
  42. Microvascular endothelial function is impaired in patients with idiopathic hyperaldosteronism., Hypertension Research, 201809
  43. Microvascular endothelial function is impaired in patients with idiopathic hyperaldosteronism, HYPERTENSION RESEARCH, 41(11), 932-938, 201811
  44. Review of the Long-term Effects of Autologous Bone-Marrow Mononuclear Cell Implantation on Clinical Outcomes in Patients with Critical Limb Ischemia, SCIENTIFIC REPORTS, 9, 20190522
  45. Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study, JOURNAL OF HYPERTENSION, 37(5), 1083-1095, 201905
  46. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study, SCIENTIFIC REPORTS, 9, 20190715
  47. Relationship between home blood pressure and vascular function in patients receiving antihypertensive drug treatment, HYPERTENSION RESEARCH, 42(8), 1175-1185, 201908
  48. Relationships Between Calcium Channel Blockers and Vascular Function Tests, AMERICAN JOURNAL OF HYPERTENSION, 32(7), 640-648, 201907
  49. Effects of the Dipeptidyl Peptidase 4 Inhibitor Alogliptin on Blood Pressure in Hypertensive Patients with Type 2 Diabetes Mellitus, AMERICAN JOURNAL OF HYPERTENSION, 32(7), 695-702, 201907
  50. Association of extremely high levels of high-density lipoprotein cholesterol with endothelial dysfunction in men, JOURNAL OF CLINICAL LIPIDOLOGY, 13(4), 664-672, 201908
  51. Elevated Plasma Renin Activity Caused by Accelerated-malignant Hypertension in a Patient with Aldosterone-producing Adenoma Complicated with Renal Insufficiency, INTERNAL MEDICINE, 58(21), 3107-3111, 2019
  52. Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 9(2), 20200121
  53. Long-Term Clinical Outcomes of Autologous Bone Marrow Mononuclear Cell Implantation in Patients With Severe Thromboangiitis Obliterans, CIRCULATION JOURNAL, 84(4), 650-655, 202004
  54. Non-Invasive Central Venous Pressure Measurement Using Enclosed-Zone Central Venous Pressure (ezCVP (TM)), CIRCULATION JOURNAL, 84(7), 1112-1117, 202007
  55. Increased arterial stiffness and cardiovascular risk prediction in controlled hypertensive patients with coronary artery disease: post hoc analysis of FMD-J (Flow-mediated Dilation Japan) Study A, HYPERTENSION RESEARCH, 43(8), 781-790, 202008
  56. Hematocrit, hemoglobin and red blood cells are associated with vascular function and vascular structure in men, SCIENTIFIC REPORTS, 10(1), 20200710
  57. Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease - Post Hoc Analysis of the FMD-J Study A, Circulation Journal, 83(5), 1064-1071, 201904
  58. Vascular function is further impaired in subjects aged 80 years or older, HYPERTENSION RESEARCH, 43(9), 914-921, 202009
  59. Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study, BMJ OPEN, 10(7), 2020
  60. Pre-impaired fasting glucose state is a risk factor for endothelial dysfunction: Flow-mediated Dilation Japan (FMD-J) study, BMJ OPEN DIABETES RESEARCH & CARE, 8(1), 2020
  61. Daily Low-intensity Pulsed Ultrasound Ameliorates Renal Fibrosis and Inflammation in Experimental Hypertensive and Diabetic Nephropathy, HYPERTENSION, 76(6), 1906-1914, 202012
  62. A Comparison of Adrenalectomy and Eplerenone on Vascular Function in Patients with Aldosterone-producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 105(11), 202011
  63. Relationship between cell number and clinical outcomes of autologous bone-marrow mononuclear cell implantation in critical limb ischemia, SCIENTIFIC REPORTS, 10(1), 20201116
  64. Endothelial function is preserved in light to moderate alcohol drinkers but is impaired in heavy drinkers in women: Flow-mediated Dilation Japan (FMD-J) study, PLOS ONE, 15(12), 20201203
  65. Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy, JOURNAL OF CLINICAL MEDICINE, 9(12), 202012
  66. Association of Body Mass Index with Endothelial Function in Asian Men, INTERNATIONAL JOURNAL OF CARDIOLOGY, 324, 186-192, 20210201
  67. Smoking status and endothelial function in Japanese men, SCIENTIFIC REPORTS, 11(1), 20210108
  68. Upstroke Time Is a Useful Vascular Marker for Detecting Patients With Coronary Artery Disease Among Subjects With Normal Ankle-Brachial Index, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 9(23), 20201201
  69. Finger blood flow after the cold challenge with primary Raynaud's syndrome: a case report, EUROPEAN HEART JOURNAL-CASE REPORTS, 4(6), 202012
  70. Lower triglyceride levels are associated with better endothelial function, JOURNAL OF CLINICAL LIPIDOLOGY, 15(3), 500-511, 2021
  71. Low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia: 5-year follow-up study, PLOS ONE, 16(8), 2021
  72. Volume Elastic Modulus, Vascular Function, and Vascular Structure in Patients with Cardiovascular Risk Factors, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 28(9), 963-973, 2021
  73. A body shape index is associated with endothelial dysfunction in both men and women, SCIENTIFIC REPORTS, 11(1), 20210909
  74. Regenerative medicine for radiation emergencies, JOURNAL OF RADIATION RESEARCH, 62, I21-I29, 202104
  75. Stair climbing activity and vascular function in patients with hypertension, HYPERTENSION RESEARCH, 44(10), 1274-1282, 202110
  76. Asymptomatic coronary aneurysms in a patient with eosinophilic granulomatosis with polyangiitis who developed a digital gangrene, MODERN RHEUMATOLOGY CASE REPORTS, 5(1), 130-136, 20210102
  77. Upstroke time as a marker of atherosclerosis in patients with diabetes mellitus who have a normal ankle-brachial index, JOURNAL OF DIABETES AND ITS COMPLICATIONS, 35(11), 202111
  78. Falsely normalized ankle-brachial index despite the presence of lower-extremity peripheral artery disease: two case reports, JOURNAL OF MEDICAL CASE REPORTS, 15(1), 20211217
  79. Vascular Dysfunction Predicts Future Deterioration of Left Ventricular Ejection Fraction in Patients with Heart Failure with Mildly Reduced Ejection Fraction, JOURNAL OF CLINICAL MEDICINE, 10(24), 202112
  80. Short stature is associated with low flow-mediated vasodilation in Japanese men, HYPERTENSION RESEARCH, 45(2), 308-314, 202202

Publications such as books

  1. 2020, Heart failure and big data., 科学評論社, 2020, 7/28, Others, Joint work

Invited Lecture, Oral Presentation, Poster Presentation

  1. A Study to Compare the Effects of Adrenalectomy and Eplerenone on Vascular Function in Patients with Aldosterone-producing Adenoma, Shinji Kishimoto, Yukihito Higashi, Yu Hashimoto, Takahiro Harada, Takayuki Yamaji, Yuji Takaeko, Farina Mohamad Yusoff, Masato Kajikawa, Tatsuya Maruhashi, Yukiko Nakano, The 85th Annual Scientific Meeting of The Japanese Circulation Society : JCS 2021, 2021/03/26, Without Invitation, English
  2. Vascular Function and Vascular Structure are Impaired in Patients with Heart Failure with Preserved Ejection Fraction, Shinji Kishimoto, Yukihito Higashi, Nozomu Oda, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Yumiko Iwamoto, Tatsuya Maruhashi, Ayumu Nakashima, Takayuki Hidaka, Kensuke Noma, Yasuki Kihara, 88th Scientific Sessions, American Heart Association, 2015/11/08, Without Invitation, English, Orlando, Florida
  3. Vascular Function and Vascular Structure are Impaired in Patients with Heart Failure with Preserved Ejection Fraction, Shinji Kishimoto, Yukihito Higashi, Nozomu Oda, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Yumiko Iwamoto, Tatsuya Maruhashi, Ayumu Nakashima, Takayuki Hidaka, Kensuke Noma, Yasuki Kihara, 2016/03/19, Without Invitation, English
  4. Vascular Function and Rho-associated Kinase Activity in Patients with Idiopathic hyperaldosteronism, Shinji Kishimoto, Takeshi Matsumoto, Shogo matsui, Nozomu Oda, Masato Kajikawa, Yumiko Iwamoto, Tatsuya Maruhashi, Ayumu Nakashima, Takayuki Hidaka, Kensuke Noma, Yasuki Kihara Yukihito Higashi, The Pulse of Asia 2016, 2016/09/24, Without Invitation, English
  5. Patients with Diastolic Ventricular Dysfunction and Ventricular Hypertrophy may occur Heart Failure with Preserved Ejection Fraction through Endothelial Dysfunction, Shinji Kishimoto,Yukihito Higashi,Haruki Hashimoto, Shogo Matsui, Masato Kajikawa, Tatsuya Maruhashi, Farina Mohamad Yusoff, Takayuki Hidaka, Kensuke Noma, Yasuki Kihara, 2018/03/24, Without Invitation, English
  6. Role of Resistin-like Molecule beta in Akt/AMPK/Hsp90/eNOS Pathway, Shinji Kishimoto, Yasuki kihara, Yukihito Higashi, the 3rd international symposium of the network-type joint usage/research center for radiation disaster medical science, 2019/01/13, Without Invitation, English
  7. Eplerenone Improves Endothelial Function, Arterial Stiffness and Rho-associated Kinase Activity in Patients with Idiopathic Hyperaldosteronism, Shinji Kishimoto, Yukihito Higashi, Yuji Takaeko, Farina Mohamad Yusoff, Haruki Hashimoto, Shogo Matsui, Masato Kajikawa, Tatsuya Maruhashi, Kensuke Noma, Yasuki Kihara, 2019/03/29, Without Invitation, English
  8. Patients with Diastolic Ventricular Hypertrophy and Ventricular Dysfunction may occur Heart Failure with Preserved Ejection Fraction through Endothelial Dysfunction, Shinji Kishimoto,Yukihito Higashi,Takayuki Yamaji,Takahiro Harada,Yuji Takaeko,Farina Mohamad Yusoff,Haruki Hashimoto,Masato Kajikawa,Tatsuya Maruhashi,Takayuki Hidaka,Yasuki Kihara, The 23rd Annual Scientific Meeting of the Japanese Heart Failure Society, 2019/10/04, Without Invitation, Japanese
  9. Eplerenone Improves Vascular Function, Arterial Stiffness and Rho-associated Kinase Activity in Patients with Idiopathic Hyperaldosteronism, Shinji Kishimoto, Yukihito Higashi, Takayuki Yamaji, Takahiro Harada Yuji Takaeko, Farina Mohamad Yusoff, Haruki Hashimoto, Shogo Matsui, Masato Kajikawa, Tatsuya Maruhashi, Kensuke Noma, Yasuki Kihara, American Heart Association Scientific Session 2019, 2019/11/15, Without Invitation, English
  10. Role of Resistin-like Molecule beta in Akt/AMPK/Hsp90/eNOS Pathway, Shinji Kishimoto, Takahiro Harada, Takayuki Yamaji, Yiming Han, Yuji Takaeko, Farina Mohamad Yusoff, Haruki Hashimoto, Masato Kajikawa, Tatsuya Maruhashi, Ayumu Nakashima, Yasuki Kihara, Yukihito Higashi, The 4th international symposium of the network-type joint usage/research center for radiation disaster medical science, 2020/02/12, Without Invitation, English

Awards

  1. 2016, Pulse of Asia 2016 Travel Grant, Pulse of Asia

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2020, 2022