鈴木 哲矢TETSUYA SUZUKI

Last Updated :2026/09/02

所属・職名
大学院医系科学研究科（薬）　助教
ホームページ
https://kakusan.hiroshima-u.ac.jp/
メールアドレス
suzukitehiroshima-u.ac.jp
その他連絡先
〒734-8553　広島県広島市南区霞1-2-3 霞総合研究棟415
TEL:082-257-5301
自己紹介
DNAの損傷による変異誘発・発癌メカニズム及びその修復メカニズムに関す研究をしています。

基本情報

主な職歴

  • 2009年04月01日, 2009年06月30日, 国立医薬品食品衛生研究所, 変異遺伝部, 非常勤職員
  • 2009年07月01日, 2012年03月31日, 国立医薬品食品衛生研究所, 変異遺伝部, リサーチレジデント
  • 2012年04月01日, 2014年08月31日, 独立行政法人労働安全衛生総合研究所, 健康障害予防研究グループ, 研究員
  • 2014年09月01日, 2019年03月31日, 広島大学, 大学院医歯薬保健学研究院, 助教

学歴

  • 北海道大学, 大学院生命科学院, 博士課程後期　生命科学専攻生命医薬科学コース, 日本, 2006年04月, 2009年03月
  • 岡山大学, 大学院自然科学研究科, 博士課程前期　薬品科学専攻, 日本, 2004年04月, 2006年03月
  • 岡山大学, 薬学部, 総合薬学科, 日本, 2000年04月, 2004年03月

学位

  • 博士（生命科学）　(北海道大学)
  • 修士（自然科学）　(岡山大学)

教育担当

  • 【学士課程】 薬学部 : 薬学科 : 薬学プログラム
  • 【博士課程前期】 医系科学研究科 : 総合健康科学専攻 : 薬科学プログラム
  • 【博士課程後期】 医系科学研究科 : 総合健康科学専攻 : 薬科学プログラム
  • 【博士課程】 医系科学研究科 : 医歯薬学専攻 : 薬学専門プログラム

担当主専攻プログラム

  • 薬学プログラム

研究分野

  • 医歯薬学 / 薬学 / 生物系薬学

研究キーワード

  • DNA修復、DNA損傷、遺伝子突然変異、遺伝毒性、癌

所属学会

教育活動

授業担当

  1. 2026年, 学部専門, セメスター（後期）, 分析科学実習
  2. 2026年, 博士課程・博士課程後期, セメスター（後期）, 先端薬科学研究概論

研究活動

学術論文（★は代表的な論文）

  1. Action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine: adenine pair triggered by MUTYH, GENES AND ENVIRONMENT, 47巻, 1号, 20251016
    DOIを用いた論文検索結果へのリンク
  2. Action-at-a-Distance Mutations Induced by the True Abasic Site, Uracil, and Nicks: Unexpectedly Lower Mutagenicity of the True Abasic Site, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 48巻, 7号, pp. 1111-1117, 202507
    DOIを用いた論文検索結果へのリンク
  3. NEIL1: The second DNA glycosylase involved in action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine, FREE RADICAL BIOLOGY AND MEDICINE, 229巻, pp. 374-383, 20250301
    DOIを用いた論文検索結果へのリンク
  4. Untargeted Mutation Triggered by Ribonucleoside Embedded in DNA, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25巻, 24号, 202412
    DOIを用いた論文検索結果へのリンク
  5. Acute exposure to dihydroxyacetone promotes genotoxicity and chromosomal instability in lung, cardiac, and liver cell models, TOXICOLOGICAL SCIENCES, 201巻, 1号, pp. 85-102, 20240621
    DOIを用いた論文検索結果へのリンク
  6. Visualization of oxidized guanine nucleotides accumulation in living cells with split MutT, NUCLEIC ACIDS RESEARCH, 52巻, 11号, pp. 6532-6542, 20240513
    DOIを用いた論文検索結果へのリンク
  7. Inhibition of Uracil DNA Glycosylase Alters Frequency and Spectrum of Action-at-a-Distance Mutations Induced by 8-Oxo-7,8-dihydroguanine, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 47巻, 7号, pp. 1275-1281, 202407
    DOIを用いた論文検索結果へのリンク
  8. Action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine are dependent on APOBEC3, MUTAGENESIS, 39巻, 1号, pp. 24-31, 20240208
    DOIを用いた論文検索結果へのリンク
  9. Easily-controllable, helper phage-free single-stranded phagemid production system, GENES AND ENVIRONMENT, 44巻, 1号, 20221116
    DOIを用いた論文検索結果へのリンク
  10. Biased distribution of action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 825巻, 2022
    DOIを用いた論文検索結果へのリンク
  11. Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine, DNA REPAIR, 111巻, 202203
    DOIを用いた論文検索結果へのリンク
  12. Assessment of the Genotoxicity of 1,2-Dichloropropane and Dichloromethane after Individual and Co-exposure by Inhalation in Mice, Journal of Occupational Health, 56巻, 3号, pp. 205-214, 20140417
  13. Unexpectedly Weak Impacts of Decreased p53 and Retinoblastoma Protein Levels on Mutagenesis by 8-Oxo-7, 8-dihydroguanine (8-Hydroxyguanine), Genes and environment, 33巻, 3号, pp. 103-108, 20110812
  14. Mutagenicity of secondary oxidation products of 8-oxo-7,8-dihydro-2 '-deoxyguanosine 5 '-triphosphate (8-hydroxy-2 '- deoxyguanosine 5 '-triphosphate), Mutation Research, 714巻, 1号, pp. 11-16, 20110902
  15. Suppression of Short Tract Gene Conversion in Episomal DNA by p53 Reduction, Genes and Environment, 36巻, 2号, pp. 65-68, 20140215
  16. UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides, DNA Repair, 6巻, 12号, pp. 1786-1793, 20071201
  17. ★, Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine, DNA Repeir, 9巻, 5号, pp. 542-550, 20100504
  18. Roles of specialized DNA polymerases in mutagenesis by 8-hydroxyguanine in human cells, Mutation Research, 686巻, 1-2号, pp. 90-95, 20100401
  19. ★, Base excision repair enzyme endonuclease III suppresses mutagenesis caused by 8-hydroxy-dGTP, DNA Repair, 7巻, 1号, pp. 88-94, 20080101
  20. Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity, Journal of Medical Chemistry, 51巻, 1号, pp. 159-166, 20080110
  21. Template properties of mutagenic cytosine analogues in reverse transcription, Nucleic Acids Research, 34巻, 22号, pp. 6438-6449, 20061127
  22. Catalytic and non-catalytic roles of DNA polymerase κ in protection of human cells against genotoxic stresses, Environmental and Molecular Mutagenesis, 56巻, 8号, pp. 650-662, 201510
  23. Hazardous effects of titanium dioxide nanoparticles on testicular function in mice, Fundamental Toxicological Sciences, 1巻, 3号, pp. 81-85, 2014
    DOIを用いた論文検索結果へのリンク
  24. In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase κ, DNA Repair, 15巻, pp. 21-28, 201403
  25. Tracing the fates of site-specifically introduced DNA adducts in the human genome, DNA Repair, 15巻, pp. 11-20, 201403
  26. Restoration of mismatch repair functions in human cell line Nalm-6, which has high efficiency for gene targeting, PLoS ONE, 8巻, pp. e61189, 20130415
  27. Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays, Environmental and Molecular Mutagenesis, 54巻, 9号, pp. 747-754, 201312
  28. Genotoxicity assessment of intravenously injected titanium dioxide nanoparticles in gpt delta transgenic mice, Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 802巻, pp. 30-37, 201605
  29. Cleavage of target DNA promotes sequence conversion with a tailed duplex, Biological and Pharmaceutical Bulletin, 39巻, 8号, pp. 1392-1395, 2016
  30. ★, Sensitivity of human cells expressing low-fidelity or weak-catalytic-activity variants of DNA polymerase zeta to genotoxic stresses, DNA Repair, 45巻, pp. 34-43, 201609
  31. ★, The role of DNA polymerase zeta in translesion synthesis across bulky DNA adducts and cross-links in human cells, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 791-792巻, pp. 35-41, 20160910
  32. ★, Mutator Phenotype and DNA Double-Strand Break Repair in BLM Helicase-Deficient Human Cells, Molecular and Cellular Biology, 36巻, 23号, pp. 2877-2889, 20161114
  33. Enhanced transgene expression by plasmid-specific recruitment of histone acetyltransferase, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 123巻, 3号, pp. 277-280, 201703
    DOIを用いた論文検索結果へのリンク
  34. Comparison of DNA fragments as donor DNAs upon sequence conversion of cleaved target DNA, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 36巻, 6号, pp. 428-434, 2017
    DOIを用いた論文検索結果へのリンク
  35. Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage, Toxicology and industrial health, 32巻, 9号, pp. 1589-1597, 201609
  36. Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells, Genes and Environment, 39巻, pp. 2, 20161201
  37. DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis, Genes and Environment, 39巻, pp. 6, 20170107
  38. Impact of DNA polymerase zeta mutations on genotoxic thresholds of oxidative mutagens, MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 828巻, pp. 10-14, 201804
    DOIを用いた論文検索結果へのリンク
  39. Reduction of Werner Syndrome Protein Enhances G:C -> A:T Transition byO(6)-Methylguanine in Human Cells, CHEMICAL RESEARCH IN TOXICOLOGY, 31巻, 5号, pp. 319-324, 201805
    DOIを用いた論文検索結果へのリンク
  40. Effects of mismatches distant from the target position on gene correction with a 5 '-tailed duplex, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 125巻, 5号, pp. 619-623, 201805
    DOIを用いた論文検索結果へのリンク
  41. Durable Transgene Expression Driven by CpG-Free and -Containing Promoters in Plasmid DNA with CpG-Free Backbone, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 41巻, 9号, pp. 1489-1493, 201809
    DOIを用いた論文検索結果へのリンク
  42. Mutations induced by 8-oxo-7,8-dihydroguanine in WRN- and DNA polymerase lambda-double knockdown cells, MUTAGENESIS, 33巻, 4号, pp. 301-310, 201807
    DOIを用いた論文検索結果へのリンク
  43. Analysis of large deletion mutations induced by abasic site analog in human cells, GENES AND ENVIRONMENT, 40巻, 20181024
    DOIを用いた論文検索結果へのリンク
  44. No enhancing effects of plasmid-specific histone acetyltransferase recruitment system on transgene expression in vivo, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 38巻, 12号, pp. 942-949, 20191202
    DOIを用いた論文検索結果へのリンク
  45. Conventional plasmid DNAs with a CpG-containing backbone achieve durable transgene expression in mouse liver, JOURNAL OF GENE MEDICINE, 22巻, 1号, 202001
    DOIを用いた論文検索結果へのリンク
  46. Large deletions and untargeted substitutions induced by abasic site analog on leading versus lagging strand templates in human cells, MUTAGENESIS, 34巻, 5-6号, pp. 421-429, 20191102
    DOIを用いた論文検索結果へのリンク
  47. Genotoxicity assessment of titanium dioxide nanoparticle accumulation of 90 days in the liver of gpt delta transgenic mice, GENES AND ENVIRONMENT, 42巻, 1号, 20200210
    DOIを用いた論文検索結果へのリンク
  48. Single-stranded DNA versus tailed duplex in sequence conversion of lacZ alpha DNA, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 39巻, 9号, pp. 1245-1250, 20200901
    DOIを用いた論文検索結果へのリンク
  49. New indicator Escherichia coli strain for rapid and accurate detection of supF mutations, GENES AND ENVIRONMENT, 42巻, 1号, 20200922
    DOIを用いた論文検索結果へのリンク
  50. Nucleic Acids-based Elucidation of Molecular Mechanisms of Mutagenesis and Development of Gene Therapy Methods, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 140巻, 12号, pp. 1433-1439, 202012
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  51. Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells, PLOS ONE, 15巻, 12号, 20201231
    DOIを用いた論文検索結果へのリンク
  52. ★, Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells, DNA REPAIR, 100巻, 20210401
    DOIを用いた論文検索結果へのリンク
  53. Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions, JOURNAL OF TOXICOLOGICAL SCIENCES, 46巻, 6号, pp. 283-288, 20210407
    DOIを用いた論文検索結果へのリンク
  54. Action-at-a-distance mutations at 5 '-GpA-3 ' sites induced by oxidised guanine in WRN-knockdown cells, MUTAGENESIS, 36巻, 5号, pp. 349-357, 20211006
    DOIを用いた論文検索結果へのリンク