TETSUYA SUZUKI

Last Updated :2026/09/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Assistant Professor
E-mail
suzukitehiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, JAPAN, Japan
TEL : (+81)82-257-5301 FAX : (+81)
Self-introduction
I study mutagensis by DNA damge and the repair mechanism.

Basic Information

Major Professional Backgrounds

  • 2009/04/01, 2009/06/30, National Institute of Health Sciences, Division of Genetics and Mutagenesis, Adjunct
  • 2009/07/01, 2012/03/31, National Institute of Health Sciences, Division of Genetics and Mutagenesis, Research Resident
  • 2012/04/01, 2014/08/31, National Institute of Occupational Safety and Health, Japan, Division of Health Effects Research, Researcher
  • 2014/09/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor

Educational Backgrounds

  • Hokkaido University, Graduate School of Life Science, Biomedical and Pharmaceutical Science course, Division of Life Science, Japan, 2006/04, 2009/03
  • Okayama University, Graduate School of Natursl Science and Technology, Division of Pharmaceutical Science, Japan, 2004/04, 2006/03
  • Okayama University, Faculty of Pharmaceutical Sciences, Department of General Pharmaceutical Sciences, Japan, 2000/04, 2004/03

Academic Degrees

  • Doctor of Philosophy, Hokkaido University
  • Master, Okayama University

Educational Activity

  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Pharmaceutical Sciences

In Charge of Primary Major Programs

  • Pharmaceutical Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Biological pharmacy

Research Keywords

  • DNA repair, DNA damage, Mutagenesis, Genotoxicity, Carcinogenesis

Affiliated Academic Societies

  • The Molecular Biology Society of Japan
    Related URL
  • The Pharmaceutical Society of Japan
    Related URL
  • The Japanese Environmental Mutagen Society
    Related URL
  • Japanese Cancer Association
    Related URL
  • The Japanese Society for Genome Editing

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, Second Semester, Experiments in Analytical Chemistry
  2. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Research in Pharmaceutical Science

Research Activities

Academic Papers

  1. Action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine: adenine pair triggered by MUTYH, GENES AND ENVIRONMENT, 47(1), 20251016
    Link to Paper Search Results by DOI
  2. Action-at-a-Distance Mutations Induced by the True Abasic Site, Uracil, and Nicks: Unexpectedly Lower Mutagenicity of the True Abasic Site, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 48(7), 1111-1117, 202507
    Link to Paper Search Results by DOI
  3. NEIL1: The second DNA glycosylase involved in action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine, FREE RADICAL BIOLOGY AND MEDICINE, 229, 374-383, 20250301
    Link to Paper Search Results by DOI
  4. Untargeted Mutation Triggered by Ribonucleoside Embedded in DNA, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(24), 202412
    Link to Paper Search Results by DOI
  5. Acute exposure to dihydroxyacetone promotes genotoxicity and chromosomal instability in lung, cardiac, and liver cell models, TOXICOLOGICAL SCIENCES, 201(1), 85-102, 20240621
    Link to Paper Search Results by DOI
  6. Visualization of oxidized guanine nucleotides accumulation in living cells with split MutT, NUCLEIC ACIDS RESEARCH, 52(11), 6532-6542, 20240513
    Link to Paper Search Results by DOI
  7. Inhibition of Uracil DNA Glycosylase Alters Frequency and Spectrum of Action-at-a-Distance Mutations Induced by 8-Oxo-7,8-dihydroguanine, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 47(7), 1275-1281, 202407
    Link to Paper Search Results by DOI
  8. Action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine are dependent on APOBEC3, MUTAGENESIS, 39(1), 24-31, 20240208
    Link to Paper Search Results by DOI
  9. Easily-controllable, helper phage-free single-stranded phagemid production system, GENES AND ENVIRONMENT, 44(1), 20221116
    Link to Paper Search Results by DOI
  10. Biased distribution of action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 825, 2022
    Link to Paper Search Results by DOI
  11. Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine, DNA REPAIR, 111, 202203
    Link to Paper Search Results by DOI
  12. Assessment of the Genotoxicity of 1,2-Dichloropropane and Dichloromethane after Individual and Co-exposure by Inhalation in Mice, Journal of Occupational Health, 56(3), 205-214, 20140417
  13. Unexpectedly Weak Impacts of Decreased p53 and Retinoblastoma Protein Levels on Mutagenesis by 8-Oxo-7, 8-dihydroguanine (8-Hydroxyguanine), Genes and environment, 33(3), 103-108, 20110812
  14. Mutagenicity of secondary oxidation products of 8-oxo-7,8-dihydro-2 '-deoxyguanosine 5 '-triphosphate (8-hydroxy-2 '- deoxyguanosine 5 '-triphosphate), Mutation Research, 714(1), 11-16, 20110902
  15. Suppression of Short Tract Gene Conversion in Episomal DNA by p53 Reduction, Genes and Environment, 36(2), 65-68, 20140215
  16. UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides, DNA Repair, 6(12), 1786-1793, 20071201
  17. ★, Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine, DNA Repair, 9(5), 542-550, 20100504
  18. Roles of specialized DNA polymerases in mutagenesis by 8-hydroxyguanine in human cells, Mutation Research, 686(1-2), 90-95, 20100401
  19. ★, Base excision repair enzyme endonuclease III suppresses mutagenesis caused by 8-hydroxy-dGTP, DNA Repair, 7(1), 88-94, 20080101
  20. Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity, Journal of Medical Chemistry, 51(1), 159-166, 20080110
  21. Template properties of mutagenic cytosine analogues in reverse transcription, Nucleic Acids Research, 34(22), 6438-6449, 20061127
  22. Catalytic and non-catalytic roles of DNA polymerase κ in protection of human cells against genotoxic stresses, Environmental and Molecular Mutagenesis, 56(8), 650-662, 201510
  23. Hazardous effects of titanium dioxide nanoparticles on testicular function in mice, Fundamental Toxicological Sciences, 1(3), 81-85, 2014
    Link to Paper Search Results by DOI
  24. In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase κ, DNA Repair, 15, 21-28, 201403
  25. Tracing the fates of site-specifically introduced DNA adducts in the human genome, DNA Repair, 15, 11-20, 201403
  26. Restoration of mismatch repair functions in human cell line Nalm-6, which has high efficiency for gene targeting, PLoS ONE, 8, e61189, 20130415
  27. Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays, Environmental and Molecular Mutagenesis, 54(9), 747-754, 201312
  28. Genotoxicity assessment of intravenously injected titanium dioxide nanoparticles in gpt delta transgenic mice, Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 802, 30-37, 201605
  29. Cleavage of target DNA promotes sequence conversion with a tailed duplex, Biological and Pharmaceutical Bulletin, 39(8), 1392-1395, 2016
  30. ★, Sensitivity of human cells expressing low-fidelity or weak-catalytic-activity variants of DNA polymerase zeta to genotoxic stresses, DNA Repair, 45, 34-43, 201609
  31. ★, The role of DNA polymerase zeta in translesion synthesis across bulky DNA adducts and cross-links in human cells, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 791-792, 35-41, 20160910
  32. ★, Mutator Phenotype and DNA Double-Strand Break Repair in BLM Helicase-Deficient Human Cells, Molecular and Cellular Biology, 36(23), 2877-2889, 20161114
  33. Enhanced transgene expression by plasmid-specific recruitment of histone acetyltransferase, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 123(3), 277-280, 201703
    Link to Paper Search Results by DOI
  34. Comparison of DNA fragments as donor DNAs upon sequence conversion of cleaved target DNA, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 36(6), 428-434, 2017
    Link to Paper Search Results by DOI
  35. Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage, Toxicology and industrial health, 32(9), 1589-1597, 201609
  36. Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells, Genes and Environment, 39, 2, 20161201
  37. DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis, Genes and Environment, 39, 6, 20170107
  38. Impact of DNA polymerase zeta mutations on genotoxic thresholds of oxidative mutagens, MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 828, 10-14, 201804
    Link to Paper Search Results by DOI
  39. Reduction of Werner Syndrome Protein Enhances G:C -> A:T Transition byO(6)-Methylguanine in Human Cells, CHEMICAL RESEARCH IN TOXICOLOGY, 31(5), 319-324, 201805
    Link to Paper Search Results by DOI
  40. Effects of mismatches distant from the target position on gene correction with a 5 '-tailed duplex, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 125(5), 619-623, 201805
    Link to Paper Search Results by DOI
  41. Durable Transgene Expression Driven by CpG-Free and -Containing Promoters in Plasmid DNA with CpG-Free Backbone, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 41(9), 1489-1493, 201809
    Link to Paper Search Results by DOI
  42. Mutations induced by 8-oxo-7,8-dihydroguanine in WRN- and DNA polymerase lambda-double knockdown cells, MUTAGENESIS, 33(4), 301-310, 201807
    Link to Paper Search Results by DOI
  43. Analysis of large deletion mutations induced by abasic site analog in human cells, GENES AND ENVIRONMENT, 40, 20181024
    Link to Paper Search Results by DOI
  44. No enhancing effects of plasmid-specific histone acetyltransferase recruitment system on transgene expression in vivo, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 38(12), 942-949, 20191202
    Link to Paper Search Results by DOI
  45. Conventional plasmid DNAs with a CpG-containing backbone achieve durable transgene expression in mouse liver, JOURNAL OF GENE MEDICINE, 22(1), 202001
    Link to Paper Search Results by DOI
  46. Large deletions and untargeted substitutions induced by abasic site analog on leading versus lagging strand templates in human cells, MUTAGENESIS, 34(5-6), 421-429, 20191102
    Link to Paper Search Results by DOI
  47. Genotoxicity assessment of titanium dioxide nanoparticle accumulation of 90 days in the liver of gpt delta transgenic mice, GENES AND ENVIRONMENT, 42(1), 20200210
    Link to Paper Search Results by DOI
  48. Single-stranded DNA versus tailed duplex in sequence conversion of lacZ alpha DNA, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 39(9), 1245-1250, 20200901
    Link to Paper Search Results by DOI
  49. New indicator Escherichia coli strain for rapid and accurate detection of supF mutations, GENES AND ENVIRONMENT, 42(1), 20200922
    Link to Paper Search Results by DOI
  50. Nucleic Acids-based Elucidation of Molecular Mechanisms of Mutagenesis and Development of Gene Therapy Methods, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 140(12), 1433-1439, 202012
    Link to Paper Search Results by DOI
  51. Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells, PLOS ONE, 15(12), 20201231
    Link to Paper Search Results by DOI
  52. ★, Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells, DNA REPAIR, 100, 20210401
    Link to Paper Search Results by DOI
  53. Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions, JOURNAL OF TOXICOLOGICAL SCIENCES, 46(6), 283-288, 20210407
    Link to Paper Search Results by DOI
  54. Action-at-a-distance mutations at 5 '-GpA-3 ' sites induced by oxidised guanine in WRN-knockdown cells, MUTAGENESIS, 36(5), 349-357, 20211006
    Link to Paper Search Results by DOI