淵上 学MANABU FUCHIKAMI

Last Updated :2022/10/03

所属・職名
大学院医系科学研究科(医) 講師
メールアドレス
mf547hiroshima-u.ac.jp

基本情報

学位

  • 博士(医学) (広島大学)

教育担当

  • 【学士課程】 医学部 : 医学科 : 医学プログラム
  • 【博士課程前期】 医系科学研究科 : 総合健康科学専攻
  • 【博士課程】 医系科学研究科 : 医歯薬学専攻 : 医学専門プログラム

研究分野

  • 医歯薬学 / 内科系臨床医学 / 精神神経科学

教育活動

授業担当

  1. 2022年, 学部専門, 通年, 脳神経医学III
  2. 2022年, 学部専門, 集中, 臨床実習I
  3. 2022年, 学部専門, 1ターム, 精神科学
  4. 2022年, 学部専門, 1ターム, 精神科学

研究活動

学術論文(★は代表的な論文)

  1. The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression, JOURNAL OF PSYCHIATRIC RESEARCH, 53巻, pp. 47-53, 201406
  2. Blood diagnostic biomarkers for major depressive disorder using multiplex DNA methylation profiles: discovery and validation, EPIGENETICS, 10巻, 2号, pp. 135-141, 201502
  3. うつ病の新たなメカニズム : エピジェネティクス, 精神神經學雜誌 = Psychiatria et neurologia Japonica, 112巻, 10号, pp. 986-991, 20101025
  4. Sodium Butyrate の抗うつ効果とラット海馬における遺伝子発現に与える影響, 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 31巻, 2号, pp. 81-83, 20110425
  5. うつ病発症感受性と養育環境(シンポジウム:脳科学による心身症の解明,2008年,第49回日本心身医学会総会(札幌)), 心身医学, 49巻, 4号, pp. 285-289, 20090401
  6. Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD, Neuropsychopharmacology, 33巻, 9号, pp. 2108-2116, 2008
  7. Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring, Hormones and Behavior, 56巻, 1号, pp. 112-120, 2009
  8. DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression, PLoS ONE, 6巻, 8号, 2011
  9. LithiumとCyclosporinの併用療法中に,lithium投与中止を余儀なくされた,強皮症を伴った双極性障害の1例, 精神医学, 48巻, 11号, pp. 1233-1236, 200611
  10. ヒストンアセチル化 (精神科領域の用語解説(第22回)), 分子精神医学, 8巻, 2号, pp. 147-149, 200804
  11. エピジェネティクスから見る向精神薬--既存向精神薬と新規治療薬に関して (特集 精神疾患のエピジェネティクス), 分子精神医学, 11巻, 2号, pp. 107-111, 201104
  12. ストレスとマイクロRNA (特集 精神疾患とマイクロRNA), 分子精神医学, 11巻, 3号, pp. 197-201, 201107
  13. BDNF遺伝子のメチル化を用いたうつ病バイオマーカーの開発 (第1土曜特集 うつ病 : 治療・研究の最前線) -- (バイオマーカー), 医学のあゆみ, 244巻, 5号, pp. 508-511, 20130202
  14. 症例 抗生剤治療によって精神症状が可逆的であった神経梅毒の1例, 精神科, 25巻, 3号, pp. 356-362, 201409
  15. Prior neonatal isolation reduces induction of NGF mRNA and decreases GDNF mRNA in the hippocampus of juvenile and adult rodents subjected to immobilization stress. , Synapse, 2008
  16. Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampus., The International Journal of Neuropsychopharmacology., 2009
  17. Single prolonged stress: toward an animal model of posttraumatic stress disorder. , Depression and Anxiety., 2009
  18. Epigenetic regulation of BDNF gene in response to stress. , Psychiatry investigation., 2010
  19. Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder. , Journal of Psychiatric Research. , 2011
  20. Antidepressant-like Effect of Sodium Butyrate (HDAC Inhibitor) and its Molecular Mechanism of Action in the Rat Hippocampus. , The world journal of biological psychiatry. , 2012
  21. Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene., Journal of Psychiatric Research. , 2012
  22. Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus., International Journal of Neuropsychopharmacology., 2013
  23. GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine. , Neuropsychopharmacology. , 2013
  24. BDNF release is required for the behavioral actions of ketamine., The International Journal of Neuropsychopharmacology. , 2014
  25. Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions. , Proceedings of the National Academy of Sciences of the United States of America., 2015
  26. Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors., Neurobiology of Disease., 2015
  27. Influence of early adverse experience on BDNF signaling, NEUROSCIENCE RESEARCH, 68巻, pp. E48-E48, 2010
  28. The potential use of histone deacetylase inhibitors in the treatment of depression, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 64巻, pp. 320-324, 2016
  29. Prior neonatal isolation reduces induction of NGF mRNA and decreases GDNF mRNA in the hippocampus of juvenile and adult rodents subjected to immobilization stress, SYNAPSE, 62巻, 4号, pp. 259-267, 2008
  30. Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampus, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 12巻, 1号, pp. 73-82, 2009
  31. SINGLE PROLONGED STRESS: TOWARD AN ANIMAL MODEL OF POSTTRAUMATIC STRESS DISORDER, DEPRESSION AND ANXIETY, 26巻, 12号, pp. 1110-1117, 2009
  32. Epigenetic Regulation of BDNF Gene in Response to Stress, PSYCHIATRY INVESTIGATION, 7巻, 4号, pp. 251-256, 2010
  33. Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder, JOURNAL OF PSYCHIATRIC RESEARCH, 45巻, 4号, pp. 460-468, 2011
  34. Biological mechanism in antidepressant-like effect of sodium butyrate (HDAC inhibitor), JOURNAL OF PHARMACOLOGICAL SCIENCES, 118巻, pp. 68P-68P, 2012
  35. Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene, JOURNAL OF PSYCHIATRIC RESEARCH, 46巻, 5号, pp. 635-643, 2012
  36. Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus, WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 13巻, 6号, pp. 458-467, 2012
  37. Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 16巻, 2号, pp. 339-350, 2013
  38. GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine, NEUROPSYCHOPHARMACOLOGY, 38巻, 11号, pp. 2268-2277, 2013
  39. The influence of aging on the methylation status of brain-derived neurotrophic factor gene in blood, INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 33巻, 10号, pp. 1312-1318, 201810
  40. Combined brain-derived neurotrophic factor with extinction training alleviate impaired fear extinction in an animal model of post-traumatic stress disorder, GENES BRAIN AND BEHAVIOR, 18巻, 7号, 201909
  41. The role of glucocorticoid receptors in the induction and prevention of hippocampal abnormalities in an animal model of posttraumatic stress disorder, PSYCHOPHARMACOLOGY, 237巻, 7号, pp. 2125-2137, 202007
  42. Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis, SCIENTIFIC REPORTS, 10巻, 1号, 20201008
  43. Chemogenetic activation of the mPFC alleviates impaired fear memory extinction in an animal model of PTSD, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 108巻, 20210608
  44. Alterations in DNA methylation rates of brain-derived neurotrophic factor in patients with schizophrenia, EUROPEAN JOURNAL OF PSYCHIATRY, 35巻, 2号, pp. 67-74, 2021
  45. Optimized protocol for the extraction of RNA and DNA from frozen whole blood sample stored in a single EDTA tube, SCIENTIFIC REPORTS, 11巻, 1号, 20210823

取得

  1. 特許権, 5828407, 2015年10月30日, 精神疾患の検査方法および精神疾患用の検査キット