MANABU FUCHIKAMI

Last Updated :2025/06/16

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Associate Professor/Lecturer
E-mail
mf547hiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Psychiatric science

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Medical Neuroscience III
  2. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  3. 2025, Undergraduate Education, 1Term, Psychiatry
  4. 2025, Undergraduate Education, 1Term, Psychiatry

Research Activities

Academic Papers

  1. Chemogenetic activation of the mPFC alleviates impaired fear memory extinction in an animal model of PTSD, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 108, 20210608
    Link to Paper Search Results by DOI
  2. Alterations in DNA methylation rates of brain-derived neurotrophic factor in patients with schizophrenia, EUROPEAN JOURNAL OF PSYCHIATRY, 35(2), 67-74, 2021
    Link to Paper Search Results by DOI
  3. Optimized protocol for the extraction of RNA and DNA from frozen whole blood sample stored in a single EDTA tube, SCIENTIFIC REPORTS, 11(1), 20210823
    Link to Paper Search Results by DOI
  4. Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis, SCIENTIFIC REPORTS, 10(1), 20201008
    Link to Paper Search Results by DOI
  5. The role of glucocorticoid receptors in the induction and prevention of hippocampal abnormalities in an animal model of posttraumatic stress disorder, PSYCHOPHARMACOLOGY, 237(7), 2125-2137, 202007
    Link to Paper Search Results by DOI
  6. Combined brain-derived neurotrophic factor with extinction training alleviate impaired fear extinction in an animal model of post-traumatic stress disorder, GENES BRAIN AND BEHAVIOR, 18(7), 201909
    Link to Paper Search Results by DOI
  7. The influence of aging on the methylation status of brain-derived neurotrophic factor gene in blood, INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 33(10), 1312-1318, 201810
    Link to Paper Search Results by DOI
  8. The potential use of histone deacetylase inhibitors in the treatment of depression, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 64, 320-324, 2016
    Link to Paper Search Results by DOI
  9. Blood diagnostic biomarkers for major depressive disorder using multiplex DNA methylation profiles: discovery and validation, EPIGENETICS, 10(2), 135-141, 201502
    Link to Paper Search Results by DOI
  10. Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions. , Proceedings of the National Academy of Sciences of the United States of America., 2015
  11. Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors., Neurobiology of Disease., 2015
  12. BDNF release is required for the behavioral actions of ketamine., The International Journal of Neuropsychopharmacology. , 2014
  13. The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression, JOURNAL OF PSYCHIATRIC RESEARCH, 53, 47-53, 201406
    Link to Paper Search Results by DOI
  14. Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 16(2), 339-350, 2013
  15. Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus., International Journal of Neuropsychopharmacology., 2013
  16. GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine, NEUROPSYCHOPHARMACOLOGY, 38(11), 2268-2277, 2013
  17. GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine. , Neuropsychopharmacology. , 2013
  18. Antidepressant-like Effect of Sodium Butyrate (HDAC Inhibitor) and its Molecular Mechanism of Action in the Rat Hippocampus. , The world journal of biological psychiatry. , 2012
  19. Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus, WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 13(6), 458-467, 2012
  20. Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene., Journal of Psychiatric Research. , 2012
  21. Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene, JOURNAL OF PSYCHIATRIC RESEARCH, 46(5), 635-643, 2012
  22. Biological mechanism in antidepressant-like effect of sodium butyrate (HDAC inhibitor), JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 68P-68P, 2012
  23. Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder, JOURNAL OF PSYCHIATRIC RESEARCH, 45(4), 460-468, 2011
  24. Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder. , Journal of Psychiatric Research. , 2011
  25. DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression, PLoS ONE, 6(8), 2011
  26. Influence of early adverse experience on BDNF signaling, NEUROSCIENCE RESEARCH, 68, E48-E48, 2010
  27. Epigenetic regulation of BDNF gene in response to stress. , Psychiatry investigation., 2010
  28. Epigenetic Regulation of BDNF Gene in Response to Stress, PSYCHIATRY INVESTIGATION, 7(4), 251-256, 2010
  29. Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampus., The International Journal of Neuropsychopharmacology., 2009
  30. Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampus, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 12(1), 73-82, 2009
  31. SINGLE PROLONGED STRESS: TOWARD AN ANIMAL MODEL OF POSTTRAUMATIC STRESS DISORDER, DEPRESSION AND ANXIETY, 26(12), 1110-1117, 2009
  32. Single prolonged stress: toward an animal model of posttraumatic stress disorder. , Depression and Anxiety., 2009
  33. Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring, Hormones and Behavior, 56(1), 112-120, 2009
  34. Prior neonatal isolation reduces induction of NGF mRNA and decreases GDNF mRNA in the hippocampus of juvenile and adult rodents subjected to immobilization stress. , Synapse, 2008
  35. Prior neonatal isolation reduces induction of NGF mRNA and decreases GDNF mRNA in the hippocampus of juvenile and adult rodents subjected to immobilization stress, SYNAPSE, 62(4), 259-267, 2008
  36. Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD, Neuropsychopharmacology, 33(9), 2108-2116, 2008
  37. A case of neurologic syphilis whose psychiatric symptoms were cured by an antibiotic treatment, 25(3), 356-362, 201409
  38. DNA methylation profile of the BDNF gene as a diagnostic biomarker in major depression, 244(5), 508-511, 20130202
  39. Epigenetic Mechanism of Depression, 112(10), 986-991, 20101025
  40. Susceptibility to Depression and Maternal Care(Symposium/Psychosomatic Disorders as Revealed by Brain Science), Japanese Journal of Psychosomatic Medicine, 49(4), 285-289, 20090401