MANABU FUCHIKAMI
Last Updated :2025/02/04
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor or Lecturer
- E-mail
- mf547
hiroshima-u.ac.jp
Basic Information
Academic Degrees
- Doctor of Philosophy in Medical Science, Hiroshima University
Educational Activity
- [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine
Research Fields
- Medicine,dentistry, and pharmacy;Clinical internal medicine;Psychiatric science
Educational Activity
Course in Charge
- 2024, Undergraduate Education, Year, Medical Neuroscience III
- 2024, Undergraduate Education, Intensive, Practice of Medicine I
- 2024, Undergraduate Education, 1Term, Psychiatry
- 2024, Undergraduate Education, 1Term, Psychiatry
Research Activities
Academic Papers
- The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression, JOURNAL OF PSYCHIATRIC RESEARCH, 53, 47-53, 201406
- Blood diagnostic biomarkers for major depressive disorder using multiplex DNA methylation profiles: discovery and validation, EPIGENETICS, 10(2), 135-141, 201502
- Epigenetic Mechanism of Depression, 112(10), 986-991, 20101025
- Susceptibility to Depression and Maternal Care(Symposium/Psychosomatic Disorders as Revealed by Brain Science), Japanese Journal of Psychosomatic Medicine, 49(4), 285-289, 20090401
- Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD, Neuropsychopharmacology, 33(9), 2108-2116, 2008
- Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring, Hormones and Behavior, 56(1), 112-120, 2009
- DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression, PLoS ONE, 6(8), 2011
- DNA methylation profile of the BDNF gene as a diagnostic biomarker in major depression, 244(5), 508-511, 20130202
- A case of neurologic syphilis whose psychiatric symptoms were cured by an antibiotic treatment, 25(3), 356-362, 201409
- Prior neonatal isolation reduces induction of NGF mRNA and decreases GDNF mRNA in the hippocampus of juvenile and adult rodents subjected to immobilization stress. , Synapse, 2008
- Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampus., The International Journal of Neuropsychopharmacology., 2009
- Single prolonged stress: toward an animal model of posttraumatic stress disorder. , Depression and Anxiety., 2009
- Epigenetic regulation of BDNF gene in response to stress. , Psychiatry investigation., 2010
- Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder. , Journal of Psychiatric Research. , 2011
- Antidepressant-like Effect of Sodium Butyrate (HDAC Inhibitor) and its Molecular Mechanism of Action in the Rat Hippocampus. , The world journal of biological psychiatry. , 2012
- Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene., Journal of Psychiatric Research. , 2012
- Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus., International Journal of Neuropsychopharmacology., 2013
- GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine. , Neuropsychopharmacology. , 2013
- BDNF release is required for the behavioral actions of ketamine., The International Journal of Neuropsychopharmacology. , 2014
- Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions. , Proceedings of the National Academy of Sciences of the United States of America., 2015
- Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors., Neurobiology of Disease., 2015
- Influence of early adverse experience on BDNF signaling, NEUROSCIENCE RESEARCH, 68, E48-E48, 2010
- The potential use of histone deacetylase inhibitors in the treatment of depression, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 64, 320-324, 2016
- Prior neonatal isolation reduces induction of NGF mRNA and decreases GDNF mRNA in the hippocampus of juvenile and adult rodents subjected to immobilization stress, SYNAPSE, 62(4), 259-267, 2008
- Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampus, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 12(1), 73-82, 2009
- SINGLE PROLONGED STRESS: TOWARD AN ANIMAL MODEL OF POSTTRAUMATIC STRESS DISORDER, DEPRESSION AND ANXIETY, 26(12), 1110-1117, 2009
- Epigenetic Regulation of BDNF Gene in Response to Stress, PSYCHIATRY INVESTIGATION, 7(4), 251-256, 2010
- Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder, JOURNAL OF PSYCHIATRIC RESEARCH, 45(4), 460-468, 2011
- Biological mechanism in antidepressant-like effect of sodium butyrate (HDAC inhibitor), JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 68P-68P, 2012
- Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene, JOURNAL OF PSYCHIATRIC RESEARCH, 46(5), 635-643, 2012
- Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus, WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 13(6), 458-467, 2012
- Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 16(2), 339-350, 2013
- GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine, NEUROPSYCHOPHARMACOLOGY, 38(11), 2268-2277, 2013
- The influence of aging on the methylation status of brain-derived neurotrophic factor gene in blood, INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 33(10), 1312-1318, 201810
- Combined brain-derived neurotrophic factor with extinction training alleviate impaired fear extinction in an animal model of post-traumatic stress disorder, GENES BRAIN AND BEHAVIOR, 18(7), 201909
- The role of glucocorticoid receptors in the induction and prevention of hippocampal abnormalities in an animal model of posttraumatic stress disorder, PSYCHOPHARMACOLOGY, 237(7), 2125-2137, 202007
- Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis, SCIENTIFIC REPORTS, 10(1), 20201008
- Chemogenetic activation of the mPFC alleviates impaired fear memory extinction in an animal model of PTSD, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 108, 20210608
- Alterations in DNA methylation rates of brain-derived neurotrophic factor in patients with schizophrenia, EUROPEAN JOURNAL OF PSYCHIATRY, 35(2), 67-74, 2021
- Optimized protocol for the extraction of RNA and DNA from frozen whole blood sample stored in a single EDTA tube, SCIENTIFIC REPORTS, 11(1), 20210823