MANABU FUCHIKAMI

Last Updated :2022/12/01

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor or Lecturer
E-mail
mf547hiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Psychiatric science

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Year, Medical Neuroscience III
  2. 2022, Undergraduate Education, Intensive, Practice of Medicine I
  3. 2022, Undergraduate Education, 1Term, Psychiatry
  4. 2022, Undergraduate Education, 1Term, Psychiatry

Research Activities

Academic Papers

  1. The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression, JOURNAL OF PSYCHIATRIC RESEARCH, 53, 47-53, 201406
  2. Blood diagnostic biomarkers for major depressive disorder using multiplex DNA methylation profiles: discovery and validation, EPIGENETICS, 10(2), 135-141, 201502
  3. Epigenetic Mechanism of Depression, 112(10), 986-991, 20101025
  4. Susceptibility to Depression and Maternal Care(Symposium/Psychosomatic Disorders as Revealed by Brain Science), Japanese Journal of Psychosomatic Medicine, 49(4), 285-289, 20090401
  5. Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD, Neuropsychopharmacology, 33(9), 2108-2116, 2008
  6. Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring, Hormones and Behavior, 56(1), 112-120, 2009
  7. DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression, PLoS ONE, 6(8), 2011
  8. DNA methylation profile of the BDNF gene as a diagnostic biomarker in major depression, 244(5), 508-511, 20130202
  9. A case of neurologic syphilis whose psychiatric symptoms were cured by an antibiotic treatment, 25(3), 356-362, 201409
  10. Prior neonatal isolation reduces induction of NGF mRNA and decreases GDNF mRNA in the hippocampus of juvenile and adult rodents subjected to immobilization stress. , Synapse, 2008
  11. Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampus., The International Journal of Neuropsychopharmacology., 2009
  12. Single prolonged stress: toward an animal model of posttraumatic stress disorder. , Depression and Anxiety., 2009
  13. Epigenetic regulation of BDNF gene in response to stress. , Psychiatry investigation., 2010
  14. Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder. , Journal of Psychiatric Research. , 2011
  15. Antidepressant-like Effect of Sodium Butyrate (HDAC Inhibitor) and its Molecular Mechanism of Action in the Rat Hippocampus. , The world journal of biological psychiatry. , 2012
  16. Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene., Journal of Psychiatric Research. , 2012
  17. Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus., International Journal of Neuropsychopharmacology., 2013
  18. GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine. , Neuropsychopharmacology. , 2013
  19. BDNF release is required for the behavioral actions of ketamine., The International Journal of Neuropsychopharmacology. , 2014
  20. Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions. , Proceedings of the National Academy of Sciences of the United States of America., 2015
  21. Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors., Neurobiology of Disease., 2015
  22. Influence of early adverse experience on BDNF signaling, NEUROSCIENCE RESEARCH, 68, E48-E48, 2010
  23. The potential use of histone deacetylase inhibitors in the treatment of depression, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 64, 320-324, 2016
  24. Prior neonatal isolation reduces induction of NGF mRNA and decreases GDNF mRNA in the hippocampus of juvenile and adult rodents subjected to immobilization stress, SYNAPSE, 62(4), 259-267, 2008
  25. Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampus, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 12(1), 73-82, 2009
  26. SINGLE PROLONGED STRESS: TOWARD AN ANIMAL MODEL OF POSTTRAUMATIC STRESS DISORDER, DEPRESSION AND ANXIETY, 26(12), 1110-1117, 2009
  27. Epigenetic Regulation of BDNF Gene in Response to Stress, PSYCHIATRY INVESTIGATION, 7(4), 251-256, 2010
  28. Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder, JOURNAL OF PSYCHIATRIC RESEARCH, 45(4), 460-468, 2011
  29. Biological mechanism in antidepressant-like effect of sodium butyrate (HDAC inhibitor), JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 68P-68P, 2012
  30. Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene, JOURNAL OF PSYCHIATRIC RESEARCH, 46(5), 635-643, 2012
  31. Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus, WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 13(6), 458-467, 2012
  32. Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 16(2), 339-350, 2013
  33. GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine, NEUROPSYCHOPHARMACOLOGY, 38(11), 2268-2277, 2013
  34. The influence of aging on the methylation status of brain-derived neurotrophic factor gene in blood, INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 33(10), 1312-1318, 201810
  35. Combined brain-derived neurotrophic factor with extinction training alleviate impaired fear extinction in an animal model of post-traumatic stress disorder, GENES BRAIN AND BEHAVIOR, 18(7), 201909
  36. The role of glucocorticoid receptors in the induction and prevention of hippocampal abnormalities in an animal model of posttraumatic stress disorder, PSYCHOPHARMACOLOGY, 237(7), 2125-2137, 202007
  37. Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis, SCIENTIFIC REPORTS, 10(1), 20201008
  38. Chemogenetic activation of the mPFC alleviates impaired fear memory extinction in an animal model of PTSD, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 108, 20210608
  39. Alterations in DNA methylation rates of brain-derived neurotrophic factor in patients with schizophrenia, EUROPEAN JOURNAL OF PSYCHIATRY, 35(2), 67-74, 2021
  40. Optimized protocol for the extraction of RNA and DNA from frozen whole blood sample stored in a single EDTA tube, SCIENTIFIC REPORTS, 11(1), 20210823