田中 友加YUKA TANAKA

Last Updated :2021/03/01

所属・職名
大学院医系科学研究科(医) 准教授
ホームページ
メールアドレス
yukasanhiroshima-u.ac.jp

基本情報

主な職歴

  • 2006年04月01日, 2009年03月31日, 広島大学, 大学院医歯薬学総合研究科, 特別研究員
  • 2009年04月01日, 2012年03月31日, 広島大学, 大学院医歯薬学総合研究科, 助教
  • 2012年04月01日, 2014年03月31日, 広島大学, 大学院医歯薬保健学研究院, 助教
  • 2014年04月01日, 2019年03月31日, 広島大学, 大学院医歯薬保健学研究院, 准教授

学歴

  • 広島大学, 大学院医歯薬学総合研究科, 創生医科学専攻博士課程, 日本, 2003年04月, 2006年03月
  • 山口大学, 医療技術短期大学部, 衛生技術学科, 日本, 1990年04月, 1993年03月

学位

  • 博士(医学) (広島大学)

研究分野

  • 医歯薬学 / 外科系臨床医学 / 外科学一般

研究キーワード

  • 移植免疫学、腫瘍免疫学、細胞生物学

所属学会

  • 国際移植学会
  • 日本がん免疫学会
  • 日本サイトメトリー学会
  • 日本免疫学会
  • 日本癌学会
  • 日本移植学会
  • 日本肝移植研究会
  • 日本肝臓学会
  • 日本再生医療学会
  • 日本組織適合性学会

教育活動

授業担当

  1. 2020年, 学部専門, 通年, 器官・システム病態制御学I
  2. 2020年, 学部専門, 集中, 医学研究実習

教育に関する受賞

  • 2015年11月11日, the TTS-JST Transplantation Science Mentee-Mentor Travel Award, International Basic Science Mentee-Mentor Awards-TSS2015, Propagated NK cells from human pluripotent stem cells exert vigorous cytotoxicity against HCC and inhibit HCV replication.
  • 2015年11月11日, the TTS-JST Transplantation Science Mentee-Mentor Travel Award, International Basic Science Mentee-Mentor Awards-TSS2015, Bacterial pathogens provoke B cells responding to blood group A-antigens to be resistant to calcineurin inhibitors through TLR-MyD88 pathway.
  • 2016年08月18日, the TTS-JST Transplantation Science Mentee-Mentor Travel Award, the 26th the International Congress of the Transplantation Society, Various pathogenic microbes induce CNI-resistance in B-cells responding to blood group antigens through TLR-MyD88 pathway
  • 2018年07月20日, TTS-JST Transplantation Science Mentee-Mentor Award, 第27回国際移植学会, 国際移植学会/日本移植学会

研究活動

学術論文(★は代表的な論文)

  1. ★, Everolimus enhances TRAIL-mediated anti-tumor activity of liver resident natural killer cells in mice, TRANSPLANT INTERNATIONAL, 33巻, 2号, pp. 229-243, 202002
  2. Successful Treatment of Chronic Myeloid Leukemia With Dasatinib After Kidney Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 52巻, 2号, pp. 600-603, 202003
  3. Memory-like Liver Natural Killer Cells are Responsible for Islet Destruction in Secondary Islet Transplantation, SCIENTIFIC REPORTS, 9巻, 20190131
  4. Clinical significance of glypican-3-positive circulating tumor cells of hepatocellular carcinoma patients: A prospective study, PLOS ONE, 14巻, 5号, 20190529
  5. Risk Factors for Refractory Ascites After Living Donor Liver Transplant, TRANSPLANTATION PROCEEDINGS, 51巻, 5号, pp. 1516-1519, 201906
  6. Postoperative Portal Hypertension Enhances Alloimmune Responses after Living-Donor Liver Transplantation in Patients and in a Mouse Model, JOURNAL OF IMMUNOLOGY, 203巻, 5号, pp. 1392-1403, 20190901
  7. Management of Refractory Ascites for Liver Transplant Candidates: A Novel Cell-free and Concentrated Ascites Reinfusion Therapy, TRANSPLANTATION PROCEEDINGS, 51巻, 8号, pp. 2740-2744, 201910
  8. Cotransplantation of preactivated mesenchymal stem cells improves intraportal engraftment of islets by inhibiting liver natural killer cells in mice, AMERICAN JOURNAL OF TRANSPLANTATION, 19巻, 10号, pp. 2732-2745, 201910
  9. Utility of Doppler Ultrasonography in Liver Transplantation With Celiac Axis Compression Syndrome: A Case Report, TRANSPLANTATION PROCEEDINGS, 51巻, 9号, pp. 3103-3106, 201911
  10. Monitoring immune response after allogeneic transplantation of mesenchymal stem cells for osteochondral repair, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 12巻, 1号, pp. E275-E286, 201801
  11. Hepatic irradiation persistently eliminates liver resident NK cells, PLOS ONE, 13巻, 6号, 20180613
  12. Effect of bevacizumab plus XELOX (CapeOX) chemotherapy on liver natural killer cell activity in colorectal cancer with resectable liver metastasis, ANNALS OF GASTROENTEROLOGICAL SURGERY, 2巻, 5号, pp. 383-393, 201809
  13. Signal regulatory protein alpha blockade potentiates tumoricidal effects of macrophages on gastroenterological neoplastic cells in syngeneic immunocompetent mice, ANNALS OF GASTROENTEROLOGICAL SURGERY, 2巻, 6号, pp. 451-462, 201811
  14. MELD and Child-Pugh Scores Are Related to Immune Status of Intrahepatic Natural Killer Cells in Liver Transplant Candidates, TRANSPLANTATION PROCEEDINGS, 49巻, 1号, pp. 98-101, 2017
  15. Role of Natural Killer Cells in the Innate Immune System After Intraportal Islet Transplantation in Mice, TRANSPLANTATION PROCEEDINGS, 49巻, 1号, pp. 139-144, 2017
  16. Fc-gamma receptor 3A polymorphism predicts the incidence of urinary tract infection in kidney-transplant recipients., HUMAN IMMUNOLOGY, 78巻, 4号, pp. 357-362, 201704
  17. PD-L1/PD-L2-expressing B-1 cells inhibit alloreactive T cells in mice, PLOS ONE, 12巻, 5号, 20170601
  18. Monitoring immune response after allogeneic transplantation of mesenchymal stem cells for osteochondral repair., J Tissue Eng Regen Med., 20170117
  19. Acute Graft Rejection and Formation of De Novo Donor-Specific Antibodies Triggered by Low Cyclosporine Levels and Interferon Therapy for Recurrent Hepatitis C Infection After Liver Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 49巻, 7号, pp. 1634-1638, 201709
  20. Hepatectomy leads to loss of TRAIL-expressing liver NK cells via downregulation of the CXCL9-CXCR3 axis in mice, PLOS ONE, 12巻, 10号, 20171031
  21. Viability of Airborne Tumor Cells during Excision by Ultrasonic Device., Surg Res Pract., 2017
  22. Effect of Fc-γ Receptor Polymorphism on Rituximab-Mediated B Cell Depletion in ABO-Incompatible Adult Living Donor Liver Transplantation., Transplant Direct., 3巻, 6号, pp. e164, 2017
  23. ★, Significant association between FOXP3 gene polymorphism and steroid-resistant acute rejection in living donor liver transplantation., Hepatol Commun., 1巻, 5号, pp. 406-420, 201706
  24. Prophylactic managements of hepatitis B viral infection in liver transplantation, WORLD JOURNAL OF GASTROENTEROLOGY, 22巻, 1号, pp. 165-175, 20160107
  25. Efficacy and Feasibility of Salvage Living Donor Liver Transplantation after Initial Liver Resection in Patients with Hepatocellular Carcinoma, DIGESTIVE SURGERY, 33巻, 1号, pp. 8-14, 2016
  26. Fc-Gamma Receptor Polymorphisms Predispose Patients to Infectious Complications After Liver Transplantation, AMERICAN JOURNAL OF TRANSPLANTATION, 16巻, 2号, pp. 625-633, 201602
  27. Functional Behavior of NKp46-Positive Intrahepatic Natural Killer Cells Against Hepatitis C Virus Reinfection After Liver Transplantation, TRANSPLANTATION, 100巻, 2号, pp. 355-364, 201602
  28. Different sensitivity of rituximab-treatment to B-cells between ABO-incompatible kidney and liver transplantation, HUMAN IMMUNOLOGY, 77巻, 6号, pp. 456-463, 201606
  29. Different sensitivities to calcineurin inhibitors between B cells responding to blood group A and B antigens., ISBT Science Series, 11巻, S1号, pp. 307-316, 201601
  30. Successful multidisciplinary treatment of refractory cytomegalovirus infection after living donor liver transplantation using mixed lymphocyte reactions: report of a case, CLINICAL JOURNAL OF GASTROENTEROLOGY, 9巻, 1号, pp. 38-42, 201602
  31. Fatty liver creates a pro-metastatic microenvironment for hepatocellular carcinoma through activation of hepatic stellate cells, INTERNATIONAL JOURNAL OF CANCER, 136巻, 4号, pp. E3-E13, 20150215
  32. Rho-Kinase Inhibitor Targeting the Liver Prevents Ischemia/Reperfusion Injury in the Steatotic Liver Without Major Systemic Adversity in Rats, LIVER TRANSPLANTATION, 21巻, 1号, pp. 123-131, 201501
  33. A Phased Desensitization Protocol With Rituximab and Bortezomib for Highly Sensitized Kidney Transplant Candidates., Transplant Direct, 1巻, 5号, pp. e17, 2015
  34. A Phased Desensitization Protocol With Rituximab and Bortezomib for Highly Sensitized Kidney Transplant Candidates, TRANSPLANTATION DIRECT, 1巻, 5号, 201506
  35. Clinical Efficacy of Simultaneous Splenectomy in Liver Transplant Recipients With Hepatitis C Virus, TRANSPLANTATION PROCEEDINGS, 46巻, 3号, pp. 770-773, 201404
  36. Potential Benefit of Mixed Lymphocyte Reaction Assay-based Immune Monitoring After Living Donor Liver Transplantation for Recipients With Autoimmune Hepatitis, TRANSPLANTATION PROCEEDINGS, 46巻, 3号, pp. 785-789, 201404
  37. Bile CXC Motif Chemokine 10 Levels Correlate With Anti-donor Cytotoxic T Cell Responses After Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 46巻, 3号, pp. 790-793, 201404
  38. Impact of alloimmune T cell responses on hepatitis C virus replication in liver transplant recipients, HUMAN IMMUNOLOGY, 75巻, 12号, pp. 1259-1267, 201412
  39. Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion, CANCER SCIENCE, 105巻, 11号, pp. 1411-1420, 201411
  40. Quantitative Effect of Natural Killer-Cell Licensing on Hepatocellular Carcinoma Recurrence after Curative Hepatectomy, CANCER IMMUNOLOGY RESEARCH, 2巻, 12号, pp. 1142-1147, 201412
  41. Fasting Enhances TRAIL-Mediated Liver Natural Killer Cell Activity via HSP70 Upregulation, PLOS ONE, 9巻, 10号, 20141030
  42. A case of gastric cancer following living donor liver transplantation., Hiroshima J Med Sci, 63巻, 1-3号, pp. 23-26, 2014
  43. Adoptive Transfer of Allogeneic Liver Sinusoidal Endothelial Cells Specifically Inhibits T-Cell Responses to Cognate Stimuli, CELL TRANSPLANTATION, 22巻, 9号, pp. 1695-1708, 2013
  44. Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates, BLOOD, 122巻, 15号, pp. 2582-2590, 20131010
  45. Attenuation of Portal Hypertension by Continuous Portal Infusion of PGE1 and Immunologic Impact in Adult-to-Adult Living-Donor Liver Transplantation, TRANSPLANTATION, 95巻, 12号, pp. 1521-1527, 20130627
  46. Mechanistic analysis of the antitumor efficacy of human natural killer cells against breast cancer cells, BREAST CANCER RESEARCH AND TREATMENT, 134巻, 1号, pp. 139-155, 201207
  47. マウスB細胞in vitro活性化モデルにおける各種免疫抑制剤感受性, 今日の移植, 25巻, pp. 236-238, 20120501
  48. m-TOR阻害薬のT細胞・B細胞サブクラス別感受性解析, 今日の移植, 25巻, pp. 504-509, 20121101
  49. 過小グラフト肝移植時のシアストレスによる肝由来免疫抑制能の破綻とその制御法に与えるシクロスポリンの影響, 今日の移植, 25巻, pp. 491-494, 20121101
  50. 血液型抗原に対するB細胞免疫応答(A型抗原とB型抗原への応答は異なる), ABO血液型不適合移植の新戦略2012, 20120601
  51. Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver, JOURNAL OF HEPATOLOGY, 56巻, 1号, pp. 146-152, 201201
  52. Optimization of Immunosuppressive Therapy Based on a Multiparametric Mixed Lymphocyte Reaction Assay Reduces Infectious Complications and Mortality in Living Donor Liver Transplant Recipients, TRANSPLANTATION PROCEEDINGS, 44巻, 2号, pp. 555-559, 201203
  53. Complex Vascular Reconstruction Using Donor's Vessel Grafts in Orthotopic Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 44巻, 2号, pp. 574-578, 201203
  54. Clinical-Scale Isolation of Interleukin-2-Stimulated Liver Natural Killer Cells for Treatment of Liver Transplantation With Hepatocellular Carcinoma, CELL TRANSPLANTATION, 21巻, 7号, pp. 1397-1406, 2012
  55. Evidence for the immunosuppressive potential of calcineurin inhibitor-sparing regimens in liver transplant recipients with impaired renal function., J Transplant., 2011
  56. Possibility of Adoptive Immunotherapy With Peripheral Blood-derived CD3(-)CD56(+) and CD3(+)CD56(+) Cells for Inducing Antihepatocellular Carcinoma and Antihepatitis C Virus Activity, JOURNAL OF IMMUNOTHERAPY, 34巻, 2号, pp. 137-146, 201103
  57. Kinetics of Cellular and Humoral Immunity in a Successful Case of Positive Crossmatch Kidney Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 43巻, 6号, pp. 2411-2414, 2011
  58. Impact of Adjuvant Immunotherapy Using Liver Allograft-Derived Lymphocytes on Bacteremia in Living-Donor Liver Transplantation, TRANSPLANTATION, 92巻, 5号, pp. 575-580, 201109
  59. Immunological Property of Antibodies against N-Glycolylneuraminic Acid Epitopes in Cytidine Monophospho-N-Acetylneuraminic Acid Hydroxylase-Deficient Mice, JOURNAL OF IMMUNOLOGY, 184巻, 6号, pp. 3269-3275, 20100315
  60. Deficiency of N-glycolylneuraminic acid and Gal alpha 1-3Gal beta 1-4GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies, XENOTRANSPLANTATION, 17巻, 6号, pp. 440-448, 2010
  61. Successful hepatitis B vaccination in liver transplant recipients with donor-specific hyporesponsiveness, TRANSPLANT INTERNATIONAL, 22巻, 8号, pp. 805-813, 200908
  62. Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice, JOURNAL OF CLINICAL INVESTIGATION, 119巻, 11号, pp. 3226-3235, 200911
  63. Role of invariant natural killer T cells in liver sinusoidal endothelian cell-induced immunosuppression among T cells with indirect allospecificty, TRANSPLANTATION, 85巻, 7号, pp. 1060-1064, 20080415
  64. Engraftment of human hepatocytes in the livers of rats bearing bone marrow reconstructed with immunodeficient mouse bone marrow cells, XENOTRANSPLANTATION, 15巻, 4号, pp. 235-245, 2008
  65. Evidence of immune tolerance to blood group antigens in a case of ABO-incompatible pediatric liver transplantation, AMERICAN JOURNAL OF TRANSPLANTATION, 7巻, 9号, pp. 2190-2194, 200709
  66. The persistent elimination of B cells responding to blood group A carbohydrates by synthetic group A carbohydrates and B-1 cell differentiation blockade: novel concept in preventing antibody-mediated rejection in ABO-incompatible transplantation, BLOOD, 110巻, 13号, pp. 4567-4575, 20071215
  67. Liver sinusoidal endothelial cells that endocytose allogeneic cells suppress T cells with indirect allospecificity, JOURNAL OF IMMUNOLOGY, 177巻, 6号, pp. 3615-3624, 20060915
  68. Adoptive transfer of TRAIL-expressing natural killer cells prevents recurrence of hepatocellular carcinoma after partial hepatectomy, TRANSPLANTATION, 82巻, 12号, pp. 1712-1719, 20061227
  69. Induction of endotoxin tolerance inhibits alloimmune responses, TRANSPLANT IMMUNOLOGY, 16巻, 3-4号, pp. 158-165, 200611
  70. Liver sinusoidal endothelial cells have a capacity for inducing nonresponsiveness of T cells across major histocompatibility complex barriers, TRANSPLANT INTERNATIONAL, 18巻, 2号, pp. 206-214, 200502
  71. Liver sinusoidal endothelial cells contribute to alloreactive T-cell tolerance induced by portal venous injection of donor splenocytes, TRANSPLANT INTERNATIONAL, 18巻, 2号, pp. 237-245, 200502
  72. ★, Low incidence of acute rejection after living-donor liver transplantation: Immunologic analyses by mixed lymphocyte reaction using a carboxyfluorescein diacetate succinimidyl ester labeling technique, TRANSPLANTATION, 79巻, 9号, pp. 1262-1267, 20050515
  73. Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice, JOURNAL OF IMMUNOLOGY, 175巻, 1号, pp. 139-146, 20050701
  74. Liver NK cells expressing TRAIL are toxic against self hepatocytes in mice, HEPATOLOGY, 39巻, 5号, pp. 1321-1331, 200405
  75. Differential diagnosis between graft-versus-host disease and hemophagocytic syndrome after living-related liver transplantation by mixed lymphocyte reaction assay, JOURNAL OF INVESTIGATIVE SURGERY, 17巻, 4号, pp. 197-202, 2004
  76. Multiparameter flow cytometric approach for simultaneous evaluation of proliferation and cytokine-secreting activity in T cells responding to allo-stimulation, IMMUNOLOGICAL INVESTIGATIONS, 33巻, 3号, pp. 309-324, 2004
  77. Limited engraftment capacity of bone marrow-derived mesenchymal cells in xenogeneic bone marrow transplantation., Transplant Proc., 35巻, 1号, pp. 504-505, 2003
  78. Multiparameter flow cytometric mixed lymphocyte reaction assay using fluorescent cytoplasmic dye for assessing phenotypic property of T cells responding to allogeneic stimulation., Transplant Proc., 35巻, 1号, pp. 557-558, 2003
  79. NOD/SCID mice engrafted with human peripheral blood lymphocytes can be a model for investigating B cells responding to blood group A carbohydrate determinant, TRANSPLANT IMMUNOLOGY, 12巻, 1号, pp. 9-18, 2003
  80. Enzyme-linked immunospot assay for detecting cells secreting antibodies against human blood group A epitopes., Transplant Proc., 35巻, 1号, pp. 555-556, 2003
  81. The role of mouse stroma in rat haematopoiesis in xenogeneic rat/mouse bone marrow transplantation chimeras, TRANSPLANTATION PROCEEDINGS, 34巻, 7号, pp. 2759-2759, 200211

招待講演、口頭・ポスター発表等

  1. 膵腎同時移植と腎臓移植における移植後免疫応答の比較検討, 石山宏平, 石田伸樹、井手健太郎、大平真裕、田原裕之、田中友加、大段秀樹, 第44回日本膵・膵島移植研究会, 2017年03月10日, 通常, 日本語
  2. 第50回日本臨床腎移植学会, 2017年02月15日, 通常, 英語
  3. The Significant Association Between FOXP3 Gene Polymorphism and Severity of Acute Cellular Rejection in Liver Transplantation., Tanaka Y, Verma S, Ohdan H., Asian Transplantation Week 2016, 2016年10月27日, 通常, 英語, Inchon, Korea
  4. DSA陽性症例における腎臓移植前抗ドナーT細胞応答性の解析, 田中友加, 井手健太郎, 大段秀樹, 第25回日本組織適合性学会大会, 2016年10月22日, 通常, 日本語, 日本組織適合性学会, 札幌
  5. CD34+細胞を用いた活性化自然免疫細胞リモデリングと抗腫瘍機能解析, 田中友加, 清水誠一, 堀田龍一, 大段秀樹., 第52回日本移植学会総会, 2016年09月29日, 通常, 日本語, 日本移植学会, 東京
  6. 細胞生物学とゲノム解析によるT細胞応答の個別モニタリングの実践, 田中友加, 石山宏平, 田原裕之, 大平真裕, 清水誠一, 小林剛 大段秀樹, 第52回日本移植学会総会, 2016年09月29日, 通常, 日本語, 日本移植学会, 東京
  7. 同種移植免疫応答監視システムの開発, 田中友加, 第35回日本運動器移植・再生医学研究会, 2016年09月24日, 招待, 日本語, 広島
  8. Human endothelial-like cells transdifferentiated from monocytes suppress allo-reactive T cells, Tanaka Y, Ohdan H., 26th International Congress of the Transplantation Society, 2016年08月18日, 通常, 英語, The Transplant Society, Hong Kong, China
  9. Foxp3遺伝子多型が肝移植後アロ免疫応答に与える影響, 田中友加, Verma Sapana,大段秀樹, 第34回日本肝移植研究会, 2016年07月07日, 通常, 日本語, 日本肝移植研究会, 旭川、北海道
  10. Impact of Immunosuppressants on Inducing Regulatory T Cells in Human Allo-Immune Responses., Tanaka Y, Ohdan H., American Transplant Congress 2016, 2016年06月12日, 通常, 英語, American Transplant Society, Boston, USA
  11. Monitoring for personalized immune-suppressive therapy., Tanaka Y., Transplantation Science Symposium Asian Regional Meetingb 2016, 2016年04月09日, 招待, 英語, The Transplantation Society, Tokyo, Japan
  12. ドナー肝臓由来活性化ナチュラルキラー細胞移入療法による肝臓移植後重症感染症予防(第I/II相試験), 大平真裕, 矢野琢也 中野亮介 田中友加 大段秀樹, 第16回日本再生医療学会総会, 2017年02月07日, 通常, 日本語

受賞

  1. 2015年11月11日, TTS-JST Transplantation Science Mentee-Mentor Travel Award, The Transplantation Society and the Japan Society for TRansplantation
  2. 2016年08月18日, the TTS-JST Transplantation Science Mentee-Mentor Travel Award, the 26th the International Congress of the Transplantation Society
  3. 2016年10月22日, 最優秀学術奨励賞, 日本組織適合性学会, DSA陽性症例における腎臓移植前抗ドナーT細胞応答性の解析
  4. 2016年10月24日, ATW 2016 Travel Grant

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業(若手研究(スタートアップ)), 末梢血単球から再生しうる内皮様細胞を用いた抗原特異的移植免疫寛容誘導法の確立, 2006年, 2007年
  2. 科学研究費助成事業(萌芽研究), 新たに同定した肝類洞内皮細胞のT細胞抑制機構を応用した移植免疫制御法の開発, 2006年, 2007年
  3. 科学研究費助成事業(若手研究(B)), CD14+単球由来内皮様細胞によるT細胞制御法の確立と移植免疫制御への応用, 2008年, 2009年
  4. 科学研究費助成事業(基盤研究(B)), CD47-SIRPシグナル制御による移植抗原反応性T細胞・B細胞性免疫応答の抑制, 2008年, 2010年
  5. 科学研究費助成事業(挑戦的萌芽研究), 肝移植後免疫クロストークから発想した増殖性NKT細胞による新規抗HCV療法の開発, 2009年, 2010年
  6. 科学研究費助成事業(若手研究(B)), 免疫グロブリン由来制御性Tエピトープによる免疫寛容機構の解明と臓器移植への応用, 2010年, 2011年
  7. 科学研究費助成事業(基盤研究(C)), 薬力学および免疫機能モニタリングによる臓器移植患者の包括的支援体制の構築, 2011年, 2013年
  8. 科学研究費助成事業(基盤研究(A)), CD47-SIRPαシグナルを介した癌細胞免疫回避機構の解明とその制御法の開発, 2011年, 2013年
  9. 科学研究費助成事業(挑戦的萌芽研究), B 細胞の分化・増殖機構に即した抗体関連拒絶反応制御法の開発, 2011年, 2012年
  10. 科学研究費助成事業(基盤研究(C)), 造血幹細胞・iPS細胞由来TRAIL陽性NK細胞による肝癌免疫細胞療法の基礎研究, 2012年, 2014年
  11. 科学研究費助成事業(挑戦的萌芽研究), 肝癌に対する分子標的薬を併用したunlicensed NK細胞療法の開発, 2013年, 2014年
  12. 科学研究費助成事業(基盤研究(C)), Foxp3遺伝子多型と細胞内シグナル解析による臓器移植の制御性T細胞応答の解明, 2015年, 2017年
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