YUKA TANAKA

Last Updated :2024/02/01

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor
Web Site
E-mail
yukasanhiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2006/04/01, 2009/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Special Postdoctoral Researcher
  • 2009/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor
  • 2012/04/01, 2014/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor
  • 2014/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Associate Professor

Educational Backgrounds

  • Hiroshima University, Japan, 2003/04, 2006/03
  • Yamaguchi University, Japan, 1990/04, 1993/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;General surgery

Research Keywords

  • Transplant Immunology, Cancer Immunology, Cellular Biology

Affiliated Academic Societies

  • The International Transplant Society
  • The Japan Society of Hepatology
  • the Japanese Society for Regenerative Medicine
  • Japanese Society for Histocompatibility and Immunogenetics

Educational Activity

Course in Charge

  1. 2023, Undergraduate Education, Intensive, Practice for medical research
  2. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Gastroenterological and Transplant Surgery
  3. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Gastroenterological and Transplant Surgery
  4. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Gastroenterological and Transplant Surgery
  5. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Gastroenterological and Transplant Surgery

Award of Education

  1. 2015/11/11, the TTS-JST Transplantation Science Mentee-Mentor Travel Award, International Basic Science Mentee-Mentor Awards-TSS2015, Propagated NK cells from human pluripotent stem cells exert vigorous cytotoxicity against HCC and inhibit HCV replication.
  2. 2015/11/11, the TTS-JST Transplantation Science Mentee-Mentor Travel Award, International Basic Science Mentee-Mentor Awards-TSS2015, Bacterial pathogens provoke B cells responding to blood group A-antigens to be resistant to calcineurin inhibitors through TLR-MyD88 pathway.
  3. 2016/08/18, the TTS-JST Transplantation Science Mentee-Mentor Travel Award, the 26th the International Congress of the Transplantation Society, Various pathogenic microbes induce CNI-resistance in B-cells responding to blood group antigens through TLR-MyD88 pathway
  4. 2018/07/20, TTS-JST Transplantation Science Mentee-Mentor Award, TTS/JST, Donor Conditioning with Recipient-Derived PD-L1/PD-L2-Expressing B Cells Prevents Lethal Acute GVHD in a Fully Allogeneic Mouse Model

Research Activities

Academic Papers

  1. Adoptive immunotherapy with natural killer cells from peripheral blood CD34(+) stem cells to prevent hepatocellular carcinoma recurrence after curative hepatectomy: a study protocol for an open-label, single-arm phase I study, BMJ OPEN, 12(11), 202211
  2. Adoptive immunotherapy overcomes genetic susceptibility to bloodstream infections due to fc-gamma receptor polymorphisms after liver transplantation, AMERICAN JOURNAL OF TRANSPLANTATION, 22(10), 2392-2400, 202210
  3. Acute portal hypertension using portal vein ligation abrogates TRAIL expression of liver-resident NK cells, HEPATOLOGY COMMUNICATIONS, 6(9), 2551-2564, 202209
  4. Polymorphisms in CTLA-4 predict de novo donor specific antibody formation after kidney transplantation, HUMAN IMMUNOLOGY, 83(6), 494-498, 202206
  5. Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice, JOURNAL OF CLINICAL INVESTIGATION, 119(11), 3226-3235, 200911
  6. Mechanistic analysis of the antitumor efficacy of human natural killer cells against breast cancer cells, BREAST CANCER RESEARCH AND TREATMENT, 134(1), 139-155, 201207
  7. The role of mouse stroma in rat haematopoiesis in xenogeneic rat/mouse bone marrow transplantation chimeras, TRANSPLANTATION PROCEEDINGS, 34(7), 2759-2759, 200211
  8. NOD/SCID mice engrafted with human peripheral blood lymphocytes can be a model for investigating B cells responding to blood group A carbohydrate determinant, TRANSPLANT IMMUNOLOGY, 12(1), 9-18, 2003
  9. Liver NK cells expressing TRAIL are toxic against self hepatocytes in mice, HEPATOLOGY, 39(5), 1321-1331, 200405
  10. Differential diagnosis between graft-versus-host disease and hemophagocytic syndrome after living-related liver transplantation by mixed lymphocyte reaction assay, JOURNAL OF INVESTIGATIVE SURGERY, 17(4), 197-202, 2004
  11. Multiparameter flow cytometric approach for simultaneous evaluation of proliferation and cytokine-secreting activity in T cells responding to allo-stimulation, IMMUNOLOGICAL INVESTIGATIONS, 33(3), 309-324, 2004
  12. Liver sinusoidal endothelial cells have a capacity for inducing nonresponsiveness of T cells across major histocompatibility complex barriers, TRANSPLANT INTERNATIONAL, 18(2), 206-214, 200502
  13. Liver sinusoidal endothelial cells contribute to alloreactive T-cell tolerance induced by portal venous injection of donor splenocytes, TRANSPLANT INTERNATIONAL, 18(2), 237-245, 200502
  14. ★, Low incidence of acute rejection after living-donor liver transplantation: Immunologic analyses by mixed lymphocyte reaction using a carboxyfluorescein diacetate succinimidyl ester labeling technique, TRANSPLANTATION, 79(9), 1262-1267, 20050515
  15. Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice, JOURNAL OF IMMUNOLOGY, 175(1), 139-146, 20050701
  16. Liver sinusoidal endothelial cells that endocytose allogeneic cells suppress T cells with indirect allospecificity, JOURNAL OF IMMUNOLOGY, 177(6), 3615-3624, 20060915
  17. Induction of endotoxin tolerance inhibits alloimmune responses, TRANSPLANT IMMUNOLOGY, 16(3-4), 158-165, 200611
  18. Adoptive transfer of TRAIL-expressing natural killer cells prevents recurrence of hepatocellular carcinoma after partial hepatectomy, TRANSPLANTATION, 82(12), 1712-1719, 20061227
  19. Evidence of immune tolerance to blood group antigens in a case of ABO-incompatible pediatric liver transplantation, AMERICAN JOURNAL OF TRANSPLANTATION, 7(9), 2190-2194, 200709
  20. The persistent elimination of B cells responding to blood group A carbohydrates by synthetic group A carbohydrates and B-1 cell differentiation blockade: novel concept in preventing antibody-mediated rejection in ABO-incompatible transplantation, BLOOD, 110(13), 4567-4575, 20071215
  21. Role of invariant natural killer T cells in liver sinusoidal endothelian cell-induced immunosuppression among T cells with indirect allospecificty, TRANSPLANTATION, 85(7), 1060-1064, 20080415
  22. Engraftment of human hepatocytes in the livers of rats bearing bone marrow reconstructed with immunodeficient mouse bone marrow cells, XENOTRANSPLANTATION, 15(4), 235-245, 2008
  23. Successful hepatitis B vaccination in liver transplant recipients with donor-specific hyporesponsiveness, TRANSPLANT INTERNATIONAL, 22(8), 805-813, 200908
  24. Immunological Property of Antibodies against N-Glycolylneuraminic Acid Epitopes in Cytidine Monophospho-N-Acetylneuraminic Acid Hydroxylase-Deficient Mice, JOURNAL OF IMMUNOLOGY, 184(6), 3269-3275, 20100315
  25. Deficiency of N-glycolylneuraminic acid and Gal alpha 1-3Gal beta 1-4GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies, XENOTRANSPLANTATION, 17(6), 440-448, 2010
  26. Possibility of Adoptive Immunotherapy With Peripheral Blood-derived CD3(-)CD56(+) and CD3(+)CD56(+) Cells for Inducing Antihepatocellular Carcinoma and Antihepatitis C Virus Activity, JOURNAL OF IMMUNOTHERAPY, 34(2), 137-146, 201103
  27. Kinetics of Cellular and Humoral Immunity in a Successful Case of Positive Crossmatch Kidney Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 43(6), 2411-2414, 2011
  28. Impact of Adjuvant Immunotherapy Using Liver Allograft-Derived Lymphocytes on Bacteremia in Living-Donor Liver Transplantation, TRANSPLANTATION, 92(5), 575-580, 201109
  29. Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver, JOURNAL OF HEPATOLOGY, 56(1), 146-152, 201201
  30. Optimization of Immunosuppressive Therapy Based on a Multiparametric Mixed Lymphocyte Reaction Assay Reduces Infectious Complications and Mortality in Living Donor Liver Transplant Recipients, TRANSPLANTATION PROCEEDINGS, 44(2), 555-559, 201203
  31. Complex Vascular Reconstruction Using Donor's Vessel Grafts in Orthotopic Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 44(2), 574-578, 201203
  32. Clinical-Scale Isolation of Interleukin-2-Stimulated Liver Natural Killer Cells for Treatment of Liver Transplantation With Hepatocellular Carcinoma, CELL TRANSPLANTATION, 21(7), 1397-1406, 2012
  33. Adoptive Transfer of Allogeneic Liver Sinusoidal Endothelial Cells Specifically Inhibits T-Cell Responses to Cognate Stimuli, CELL TRANSPLANTATION, 22(9), 1695-1708, 2013
  34. Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates, BLOOD, 122(15), 2582-2590, 20131010
  35. Attenuation of Portal Hypertension by Continuous Portal Infusion of PGE1 and Immunologic Impact in Adult-to-Adult Living-Donor Liver Transplantation, TRANSPLANTATION, 95(12), 1521-1527, 20130627
  36. Clinical Efficacy of Simultaneous Splenectomy in Liver Transplant Recipients With Hepatitis C Virus, TRANSPLANTATION PROCEEDINGS, 46(3), 770-773, 201404
  37. Potential Benefit of Mixed Lymphocyte Reaction Assay-based Immune Monitoring After Living Donor Liver Transplantation for Recipients With Autoimmune Hepatitis, TRANSPLANTATION PROCEEDINGS, 46(3), 785-789, 201404
  38. Bile CXC Motif Chemokine 10 Levels Correlate With Anti-donor Cytotoxic T Cell Responses After Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 46(3), 790-793, 201404
  39. Fatty liver creates a pro-metastatic microenvironment for hepatocellular carcinoma through activation of hepatic stellate cells, INTERNATIONAL JOURNAL OF CANCER, 136(4), E3-E13, 20150215
  40. Rho-Kinase Inhibitor Targeting the Liver Prevents Ischemia/Reperfusion Injury in the Steatotic Liver Without Major Systemic Adversity in Rats, LIVER TRANSPLANTATION, 21(1), 123-131, 201501
  41. Impact of alloimmune T cell responses on hepatitis C virus replication in liver transplant recipients, HUMAN IMMUNOLOGY, 75(12), 1259-1267, 201412
  42. Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion, CANCER SCIENCE, 105(11), 1411-1420, 201411
  43. Quantitative Effect of Natural Killer-Cell Licensing on Hepatocellular Carcinoma Recurrence after Curative Hepatectomy, CANCER IMMUNOLOGY RESEARCH, 2(12), 1142-1147, 201412
  44. Fasting Enhances TRAIL-Mediated Liver Natural Killer Cell Activity via HSP70 Upregulation, PLOS ONE, 9(10), 20141030
  45. Limited engraftment capacity of bone marrow-derived mesenchymal cells in xenogeneic bone marrow transplantation., Transplant Proc., 35(1), 504-505, 2003
  46. Enzyme-linked immunospot assay for detecting cells secreting antibodies against human blood group A epitopes., Transplant Proc., 35(1), 555-556, 2003
  47. Multiparameter flow cytometric mixed lymphocyte reaction assay using fluorescent cytoplasmic dye for assessing phenotypic property of T cells responding to allogeneic stimulation., Transplant Proc., 35(1), 557-558, 2003
  48. Evidence for the immunosuppressive potential of calcineurin inhibitor-sparing regimens in liver transplant recipients with impaired renal function., J Transplant., 2011
  49. A case of gastric cancer following living donor liver transplantation., Hiroshima J Med Sci, 63(1-3), 23-26, 2014
  50. Prophylactic managements of hepatitis B viral infection in liver transplantation, WORLD JOURNAL OF GASTROENTEROLOGY, 22(1), 165-175, 20160107
  51. Efficacy and Feasibility of Salvage Living Donor Liver Transplantation after Initial Liver Resection in Patients with Hepatocellular Carcinoma, DIGESTIVE SURGERY, 33(1), 8-14, 2016
  52. Fc-Gamma Receptor Polymorphisms Predispose Patients to Infectious Complications After Liver Transplantation, AMERICAN JOURNAL OF TRANSPLANTATION, 16(2), 625-633, 201602
  53. Functional Behavior of NKp46-Positive Intrahepatic Natural Killer Cells Against Hepatitis C Virus Reinfection After Liver Transplantation, TRANSPLANTATION, 100(2), 355-364, 201602
  54. Different sensitivity of rituximab-treatment to B-cells between ABO-incompatible kidney and liver transplantation, HUMAN IMMUNOLOGY, 77(6), 456-463, 201606
  55. A Phased Desensitization Protocol With Rituximab and Bortezomib for Highly Sensitized Kidney Transplant Candidates., Transplant Direct, 1(5), e17, 2015
  56. MELD and Child-Pugh Scores Are Related to Immune Status of Intrahepatic Natural Killer Cells in Liver Transplant Candidates, TRANSPLANTATION PROCEEDINGS, 49(1), 98-101, 2017
  57. Role of Natural Killer Cells in the Innate Immune System After Intraportal Islet Transplantation in Mice, TRANSPLANTATION PROCEEDINGS, 49(1), 139-144, 2017
  58. Fc-gamma receptor 3A polymorphism predicts the incidence of urinary tract infection in kidney-transplant recipients., HUMAN IMMUNOLOGY, 78(4), 357-362, 201704
  59. PD-L1/PD-L2-expressing B-1 cells inhibit alloreactive T cells in mice, PLOS ONE, 12(5), 20170601
  60. Different sensitivities to calcineurin inhibitors between B cells responding to blood group A and B antigens., ISBT Science Series, 11(S1), 307-316, 201601
  61. Monitoring immune response after allogeneic transplantation of mesenchymal stem cells for osteochondral repair., J Tissue Eng Regen Med., 20170117
  62. Acute Graft Rejection and Formation of De Novo Donor-Specific Antibodies Triggered by Low Cyclosporine Levels and Interferon Therapy for Recurrent Hepatitis C Infection After Liver Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 49(7), 1634-1638, 201709
  63. Hepatectomy leads to loss of TRAIL-expressing liver NK cells via downregulation of the CXCL9-CXCR3 axis in mice, PLOS ONE, 12(10), 20171031
  64. Monitoring immune response after allogeneic transplantation of mesenchymal stem cells for osteochondral repair, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 12(1), E275-E286, 201801
  65. Successful multidisciplinary treatment of refractory cytomegalovirus infection after living donor liver transplantation using mixed lymphocyte reactions: report of a case, CLINICAL JOURNAL OF GASTROENTEROLOGY, 9(1), 38-42, 201602
  66. A Phased Desensitization Protocol With Rituximab and Bortezomib for Highly Sensitized Kidney Transplant Candidates, TRANSPLANTATION DIRECT, 1(5), 201506
  67. Hepatic irradiation persistently eliminates liver resident NK cells, PLOS ONE, 13(6), 20180613
  68. Viability of Airborne Tumor Cells during Excision by Ultrasonic Device., Surg Res Pract., 2017
  69. Effect of Fc-γ Receptor Polymorphism on Rituximab-Mediated B Cell Depletion in ABO-Incompatible Adult Living Donor Liver Transplantation., Transplant Direct., 3(6), e164, 201705
  70. ★, Significant association between FOXP3 gene polymorphism and steroid-resistant acute rejection in living donor liver transplantation., Hepatol Commun., 1(5), 406-420, 201706
  71. Effect of bevacizumab plus XELOX (CapeOX) chemotherapy on liver natural killer cell activity in colorectal cancer with resectable liver metastasis, ANNALS OF GASTROENTEROLOGICAL SURGERY, 2(5), 383-393, 201809
  72. Signal regulatory protein alpha blockade potentiates tumoricidal effects of macrophages on gastroenterological neoplastic cells in syngeneic immunocompetent mice, ANNALS OF GASTROENTEROLOGICAL SURGERY, 2(6), 451-462, 201811
  73. Memory-like Liver Natural Killer Cells are Responsible for Islet Destruction in Secondary Islet Transplantation, SCIENTIFIC REPORTS, 9, 20190131
  74. Significant Association Between FOXP3 Gene Polymorphism and Steroid-Resistant Acute Rejection in Living Donor Liver Transplantation, HEPATOLOGY COMMUNICATIONS, 1(5), 406-420, 201707
  75. Clinical significance of glypican-3-positive circulating tumor cells of hepatocellular carcinoma patients: A prospective study, PLOS ONE, 14(5), 20190529
  76. Risk Factors for Refractory Ascites After Living Donor Liver Transplant, TRANSPLANTATION PROCEEDINGS, 51(5), 1516-1519, 201906
  77. Postoperative Portal Hypertension Enhances Alloimmune Responses after Living-Donor Liver Transplantation in Patients and in a Mouse Model, JOURNAL OF IMMUNOLOGY, 203(5), 1392-1403, 20190901
  78. Management of Refractory Ascites for Liver Transplant Candidates: A Novel Cell-free and Concentrated Ascites Reinfusion Therapy, TRANSPLANTATION PROCEEDINGS, 51(8), 2740-2744, 201910
  79. Cotransplantation of preactivated mesenchymal stem cells improves intraportal engraftment of islets by inhibiting liver natural killer cells in mice, AMERICAN JOURNAL OF TRANSPLANTATION, 19(10), 2732-2745, 201910
  80. Utility of Doppler Ultrasonography in Liver Transplantation With Celiac Axis Compression Syndrome: A Case Report, TRANSPLANTATION PROCEEDINGS, 51(9), 3103-3106, 201911
  81. ★, Everolimus enhances TRAIL-mediated anti-tumor activity of liver resident natural killer cells in mice, TRANSPLANT INTERNATIONAL, 33(2), 229-243, 202002
  82. Successful Treatment of Chronic Myeloid Leukemia With Dasatinib After Kidney Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 52(2), 600-603, 202003
  83. Strategies for Deliberate Induction of Immune Tolerance in Liver Transplantation: From Preclinical Models to Clinical Application, FRONTIERS IN IMMUNOLOGY, 11, 20200731
  84. Impact on biliary complications of donor abdominal aortic calcification among living donor liver transplantation: a retrospective study, TRANSPLANT INTERNATIONAL, 33(12), 1745-1753, 202012
  85. Analysis of Risk Factors Affecting Incidence of Osteoporosis and Fragility Fractures in Liver Transplant Recipients, ANNALS OF TRANSPLANTATION, 26, 20210205
  86. Development of a humanized mouse model to analyze antibodies specific for human leukocyte antigen (HLA), PLOS ONE, 16(2), 20210205
  87. TLR-MyD88 signaling blockades inhibit refractory B-1b cell immune responses to transplant-related glycan antigens, AMERICAN JOURNAL OF TRANSPLANTATION, 21(4), 1427-1439, 202104
  88. Tumor endothelial cell-mediated antigen-specific T-cell suppression via the PD-1/PD-L1 pathway, Mol Cancer Res., 18(9), 1427-1440, 20200918
  89. B cell depletion with anti-CD20 mAb exacerbates anti-donor CD4(+) T cell responses in highly sensitized transplant recipients, SCIENTIFIC REPORTS, 11(1), 20210913
  90. Molecular Mismatch Predicts T Cell-Mediated Rejection and De Novo Donor-Specific Antibody Formation After Living Donor Liver Transplantation, LIVER TRANSPLANTATION, 27(11), 1592-1602, 202111
  91. Impacts of single nucleotide polymorphisms in Fc gamma receptor IIA (rs1801274) on lung transplant outcomes among Japanese lung transplant recipients, TRANSPLANT INTERNATIONAL, 34(11), 2192-2204, 202111
  92. Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study, ANNALS OF GASTROENTEROLOGICAL SURGERY, 6(1), 149-158, 202201
  93. Pilot study to determine the safety and feasibility of deceased donor liver natural killer cell infusion to liver transplant recipients with hepatocellular carcinoma, CANCER IMMUNOLOGY IMMUNOTHERAPY, 71(3), 589-599, 202203

Invited Lecture, Oral Presentation, Poster Presentation

  1. Current status of desensitization protocol for highly HLA-sensitized kidney transplant candidates, Kentaro Ide, Hiroyuki Tahara, Asuka Tanaka, Shuji Akimoto, Sapana Verma, Lalit Kumar Das, Seiichi Shimizu, Masahiro Ohira, Kohei Ishiyama, Yuka Tanaka, Hideki Ohdan, 2017/02/15, Without Invitation, English
  2. The Significant Association Between FOXP3 Gene Polymorphism and Severity of Acute Cellular Rejection in Liver Transplantation., Tanaka Y, Verma S, Ohdan H., Asian Transplantation Week 2016, 2016/10/27, Without Invitation, English, Inchon, Korea
  3. Human endothelial-like cells transdifferentiated from monocytes suppress allo-reactive T cells, Tanaka Y, Ohdan H., 26th International Congress of the Transplantation Society, 2016/08/18, Without Invitation, English, The Transplant Society, Hong Kong, China
  4. Impact of Immunosuppressants on Inducing Regulatory T Cells in Human Allo-Immune Responses., Tanaka Y, Ohdan H., American Transplant Congress 2016, 2016/06/12, Without Invitation, English, American Transplant Society, Boston, USA
  5. Monitoring for personalized immune-suppressive therapy., Tanaka Y., Transplantation Science Symposium Asian Regional Meetingb 2016, 2016/04/09, With Invitation, English, The Transplantation Society, Tokyo, Japan

Awards

  1. 2015/11/11, TTS-JST Transplantation Science Mentee-Mentor Travel Award, The Transplantation Society and the Japan Society for TRansplantation
  2. 2016/08/18, the TTS-JST Transplantation Science Mentee-Mentor Travel Award, the 26th the International Congress of the Transplantation Society
  3. 2016/10/24, ATW 2016 Travel Grant

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, The CD47-SIRPa signaling blockade accelerates macrophage phagocytic activity against cancer cells, 2011, 2013
  2. KAKENHI, Establishment of strategies to regulate antibody-mediated rejection on the basis of B cell differentiation biology, 2011, 2012
  3. KAKENHI, 2012, 2014
  4. KAKENHI, 2013, 2014
  5. KAKENHI, 2015, 2017
  6. KAKENHI, 2015, 2018
  7. KAKENHI, 2015, 2017
  8. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2020