YUKA TANAKA
Last Updated :2025/04/03
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor
- Web Site
- E-mail
- yukasan
hiroshima-u.ac.jp
Basic Information
Major Professional Backgrounds
- 2006/04/01, 2009/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Special Postdoctoral Researcher
- 2009/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor
- 2012/04/01, 2014/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor
- 2014/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Associate Professor
Educational Backgrounds
- Hiroshima University, Japan, 2003/04, 2006/03
- Yamaguchi University, Japan, 1990/04, 1993/03
Academic Degrees
- Doctor of Philosophy in Medical Science, Hiroshima University
Research Fields
- Medicine,dentistry, and pharmacy;Clinical surgery;General surgery
Research Keywords
- Transplant Immunology, Cancer Immunology, Cellular Biology
Affiliated Academic Societies
- The International Transplant Society
- The Japan Society of Hepatology
- the Japanese Society for Regenerative Medicine
- Japanese Society for Histocompatibility and Immunogenetics
Educational Activity
Course in Charge
- 2025, Undergraduate Education, Intensive, Practice for medical research
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Gastroenterological and Transplant Surgery
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Gastroenterological and Transplant Surgery
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Gastroenterological and Transplant Surgery
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Gastroenterological and Transplant Surgery
Award of Education
- 2015/11/11, the TTS-JST Transplantation Science Mentee-Mentor Travel Award, International Basic Science Mentee-Mentor Awards-TSS2015, Propagated NK cells from human pluripotent stem cells exert vigorous cytotoxicity against HCC and inhibit HCV replication.
- 2015/11/11, the TTS-JST Transplantation Science Mentee-Mentor Travel Award, International Basic Science Mentee-Mentor Awards-TSS2015, Bacterial pathogens provoke B cells responding to blood group A-antigens to be resistant to calcineurin inhibitors through TLR-MyD88 pathway.
- 2016/08/18, the TTS-JST Transplantation Science Mentee-Mentor Travel Award, the 26th the International Congress of the Transplantation Society, Various pathogenic microbes induce CNI-resistance in B-cells responding to blood group antigens through TLR-MyD88 pathway
- 2018/07/20, TTS-JST Transplantation Science Mentee-Mentor Award, TTS/JST, Donor Conditioning with Recipient-Derived PD-L1/PD-L2-Expressing B Cells Prevents Lethal Acute GVHD in a Fully Allogeneic Mouse Model
Research Activities
Academic Papers
- Adoptive immunotherapy with natural killer cells from peripheral blood CD34(+) stem cells to prevent hepatocellular carcinoma recurrence after curative hepatectomy: a study protocol for an open-label, single-arm phase I study, BMJ OPEN, 12(11), 202211
- Adoptive immunotherapy overcomes genetic susceptibility to bloodstream infections due to fc-gamma receptor polymorphisms after liver transplantation, AMERICAN JOURNAL OF TRANSPLANTATION, 22(10), 2392-2400, 202210
- Acute portal hypertension using portal vein ligation abrogates TRAIL expression of liver-resident NK cells, HEPATOLOGY COMMUNICATIONS, 6(9), 2551-2564, 202209
- Polymorphisms in CTLA-4 predict de novo donor specific antibody formation after kidney transplantation, HUMAN IMMUNOLOGY, 83(6), 494-498, 202206
- Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice, JOURNAL OF CLINICAL INVESTIGATION, 119(11), 3226-3235, 200911
- Mechanistic analysis of the antitumor efficacy of human natural killer cells against breast cancer cells, BREAST CANCER RESEARCH AND TREATMENT, 134(1), 139-155, 201207
- The role of mouse stroma in rat haematopoiesis in xenogeneic rat/mouse bone marrow transplantation chimeras, TRANSPLANTATION PROCEEDINGS, 34(7), 2759-2759, 200211
- NOD/SCID mice engrafted with human peripheral blood lymphocytes can be a model for investigating B cells responding to blood group A carbohydrate determinant, TRANSPLANT IMMUNOLOGY, 12(1), 9-18, 2003
- Liver NK cells expressing TRAIL are toxic against self hepatocytes in mice, HEPATOLOGY, 39(5), 1321-1331, 200405
- Differential diagnosis between graft-versus-host disease and hemophagocytic syndrome after living-related liver transplantation by mixed lymphocyte reaction assay, JOURNAL OF INVESTIGATIVE SURGERY, 17(4), 197-202, 2004
- Multiparameter flow cytometric approach for simultaneous evaluation of proliferation and cytokine-secreting activity in T cells responding to allo-stimulation, IMMUNOLOGICAL INVESTIGATIONS, 33(3), 309-324, 2004
- Liver sinusoidal endothelial cells have a capacity for inducing nonresponsiveness of T cells across major histocompatibility complex barriers, TRANSPLANT INTERNATIONAL, 18(2), 206-214, 200502
- Liver sinusoidal endothelial cells contribute to alloreactive T-cell tolerance induced by portal venous injection of donor splenocytes, TRANSPLANT INTERNATIONAL, 18(2), 237-245, 200502
- ★, Low incidence of acute rejection after living-donor liver transplantation: Immunologic analyses by mixed lymphocyte reaction using a carboxyfluorescein diacetate succinimidyl ester labeling technique, TRANSPLANTATION, 79(9), 1262-1267, 20050515
- Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice, JOURNAL OF IMMUNOLOGY, 175(1), 139-146, 20050701
- Liver sinusoidal endothelial cells that endocytose allogeneic cells suppress T cells with indirect allospecificity, JOURNAL OF IMMUNOLOGY, 177(6), 3615-3624, 20060915
- Induction of endotoxin tolerance inhibits alloimmune responses, TRANSPLANT IMMUNOLOGY, 16(3-4), 158-165, 200611
- Adoptive transfer of TRAIL-expressing natural killer cells prevents recurrence of hepatocellular carcinoma after partial hepatectomy, TRANSPLANTATION, 82(12), 1712-1719, 20061227
- Evidence of immune tolerance to blood group antigens in a case of ABO-incompatible pediatric liver transplantation, AMERICAN JOURNAL OF TRANSPLANTATION, 7(9), 2190-2194, 200709
- The persistent elimination of B cells responding to blood group A carbohydrates by synthetic group A carbohydrates and B-1 cell differentiation blockade: novel concept in preventing antibody-mediated rejection in ABO-incompatible transplantation, BLOOD, 110(13), 4567-4575, 20071215
- Role of invariant natural killer T cells in liver sinusoidal endothelian cell-induced immunosuppression among T cells with indirect allospecificty, TRANSPLANTATION, 85(7), 1060-1064, 20080415
- Engraftment of human hepatocytes in the livers of rats bearing bone marrow reconstructed with immunodeficient mouse bone marrow cells, XENOTRANSPLANTATION, 15(4), 235-245, 2008
- Successful hepatitis B vaccination in liver transplant recipients with donor-specific hyporesponsiveness, TRANSPLANT INTERNATIONAL, 22(8), 805-813, 200908
- Immunological Property of Antibodies against N-Glycolylneuraminic Acid Epitopes in Cytidine Monophospho-N-Acetylneuraminic Acid Hydroxylase-Deficient Mice, JOURNAL OF IMMUNOLOGY, 184(6), 3269-3275, 20100315
- Deficiency of N-glycolylneuraminic acid and Gal alpha 1-3Gal beta 1-4GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies, XENOTRANSPLANTATION, 17(6), 440-448, 2010
- Possibility of Adoptive Immunotherapy With Peripheral Blood-derived CD3(-)CD56(+) and CD3(+)CD56(+) Cells for Inducing Antihepatocellular Carcinoma and Antihepatitis C Virus Activity, JOURNAL OF IMMUNOTHERAPY, 34(2), 137-146, 201103
- Kinetics of Cellular and Humoral Immunity in a Successful Case of Positive Crossmatch Kidney Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 43(6), 2411-2414, 2011
- Impact of Adjuvant Immunotherapy Using Liver Allograft-Derived Lymphocytes on Bacteremia in Living-Donor Liver Transplantation, TRANSPLANTATION, 92(5), 575-580, 201109
- Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver, JOURNAL OF HEPATOLOGY, 56(1), 146-152, 201201
- Optimization of Immunosuppressive Therapy Based on a Multiparametric Mixed Lymphocyte Reaction Assay Reduces Infectious Complications and Mortality in Living Donor Liver Transplant Recipients, TRANSPLANTATION PROCEEDINGS, 44(2), 555-559, 201203
- Complex Vascular Reconstruction Using Donor's Vessel Grafts in Orthotopic Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 44(2), 574-578, 201203
- Clinical-Scale Isolation of Interleukin-2-Stimulated Liver Natural Killer Cells for Treatment of Liver Transplantation With Hepatocellular Carcinoma, CELL TRANSPLANTATION, 21(7), 1397-1406, 2012
- Adoptive Transfer of Allogeneic Liver Sinusoidal Endothelial Cells Specifically Inhibits T-Cell Responses to Cognate Stimuli, CELL TRANSPLANTATION, 22(9), 1695-1708, 2013
- Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates, BLOOD, 122(15), 2582-2590, 20131010
- Attenuation of Portal Hypertension by Continuous Portal Infusion of PGE1 and Immunologic Impact in Adult-to-Adult Living-Donor Liver Transplantation, TRANSPLANTATION, 95(12), 1521-1527, 20130627
- Clinical Efficacy of Simultaneous Splenectomy in Liver Transplant Recipients With Hepatitis C Virus, TRANSPLANTATION PROCEEDINGS, 46(3), 770-773, 201404
- Potential Benefit of Mixed Lymphocyte Reaction Assay-based Immune Monitoring After Living Donor Liver Transplantation for Recipients With Autoimmune Hepatitis, TRANSPLANTATION PROCEEDINGS, 46(3), 785-789, 201404
- Bile CXC Motif Chemokine 10 Levels Correlate With Anti-donor Cytotoxic T Cell Responses After Liver Transplantation, TRANSPLANTATION PROCEEDINGS, 46(3), 790-793, 201404
- Fatty liver creates a pro-metastatic microenvironment for hepatocellular carcinoma through activation of hepatic stellate cells, INTERNATIONAL JOURNAL OF CANCER, 136(4), E3-E13, 20150215
- Rho-Kinase Inhibitor Targeting the Liver Prevents Ischemia/Reperfusion Injury in the Steatotic Liver Without Major Systemic Adversity in Rats, LIVER TRANSPLANTATION, 21(1), 123-131, 201501
- Impact of alloimmune T cell responses on hepatitis C virus replication in liver transplant recipients, HUMAN IMMUNOLOGY, 75(12), 1259-1267, 201412
- Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion, CANCER SCIENCE, 105(11), 1411-1420, 201411
- Quantitative Effect of Natural Killer-Cell Licensing on Hepatocellular Carcinoma Recurrence after Curative Hepatectomy, CANCER IMMUNOLOGY RESEARCH, 2(12), 1142-1147, 201412
- Fasting Enhances TRAIL-Mediated Liver Natural Killer Cell Activity via HSP70 Upregulation, PLOS ONE, 9(10), 20141030
- Limited engraftment capacity of bone marrow-derived mesenchymal cells in xenogeneic bone marrow transplantation., Transplant Proc., 35(1), 504-505, 2003
- Enzyme-linked immunospot assay for detecting cells secreting antibodies against human blood group A epitopes., Transplant Proc., 35(1), 555-556, 2003
- Multiparameter flow cytometric mixed lymphocyte reaction assay using fluorescent cytoplasmic dye for assessing phenotypic property of T cells responding to allogeneic stimulation., Transplant Proc., 35(1), 557-558, 2003
- Evidence for the immunosuppressive potential of calcineurin inhibitor-sparing regimens in liver transplant recipients with impaired renal function., J Transplant., 2011
- A case of gastric cancer following living donor liver transplantation., Hiroshima J Med Sci, 63(1-3), 23-26, 2014
- Prophylactic managements of hepatitis B viral infection in liver transplantation, WORLD JOURNAL OF GASTROENTEROLOGY, 22(1), 165-175, 20160107
- Efficacy and Feasibility of Salvage Living Donor Liver Transplantation after Initial Liver Resection in Patients with Hepatocellular Carcinoma, DIGESTIVE SURGERY, 33(1), 8-14, 2016
- Fc-Gamma Receptor Polymorphisms Predispose Patients to Infectious Complications After Liver Transplantation, AMERICAN JOURNAL OF TRANSPLANTATION, 16(2), 625-633, 201602
- Functional Behavior of NKp46-Positive Intrahepatic Natural Killer Cells Against Hepatitis C Virus Reinfection After Liver Transplantation, TRANSPLANTATION, 100(2), 355-364, 201602
- Different sensitivity of rituximab-treatment to B-cells between ABO-incompatible kidney and liver transplantation, HUMAN IMMUNOLOGY, 77(6), 456-463, 201606
- A Phased Desensitization Protocol With Rituximab and Bortezomib for Highly Sensitized Kidney Transplant Candidates., Transplant Direct, 1(5), e17, 2015
- MELD and Child-Pugh Scores Are Related to Immune Status of Intrahepatic Natural Killer Cells in Liver Transplant Candidates, TRANSPLANTATION PROCEEDINGS, 49(1), 98-101, 2017
- Role of Natural Killer Cells in the Innate Immune System After Intraportal Islet Transplantation in Mice, TRANSPLANTATION PROCEEDINGS, 49(1), 139-144, 2017
- Fc-gamma receptor 3A polymorphism predicts the incidence of urinary tract infection in kidney-transplant recipients., HUMAN IMMUNOLOGY, 78(4), 357-362, 201704
- PD-L1/PD-L2-expressing B-1 cells inhibit alloreactive T cells in mice, PLOS ONE, 12(5), 20170601
- Different sensitivities to calcineurin inhibitors between B cells responding to blood group A and B antigens., ISBT Science Series, 11(S1), 307-316, 201601
- Monitoring immune response after allogeneic transplantation of mesenchymal stem cells for osteochondral repair., J Tissue Eng Regen Med., 20170117
- Acute Graft Rejection and Formation of De Novo Donor-Specific Antibodies Triggered by Low Cyclosporine Levels and Interferon Therapy for Recurrent Hepatitis C Infection After Liver Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 49(7), 1634-1638, 201709
- Hepatectomy leads to loss of TRAIL-expressing liver NK cells via downregulation of the CXCL9-CXCR3 axis in mice, PLOS ONE, 12(10), 20171031
- Monitoring immune response after allogeneic transplantation of mesenchymal stem cells for osteochondral repair, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 12(1), E275-E286, 201801
- Successful multidisciplinary treatment of refractory cytomegalovirus infection after living donor liver transplantation using mixed lymphocyte reactions: report of a case, CLINICAL JOURNAL OF GASTROENTEROLOGY, 9(1), 38-42, 201602
- A Phased Desensitization Protocol With Rituximab and Bortezomib for Highly Sensitized Kidney Transplant Candidates, TRANSPLANTATION DIRECT, 1(5), 201506
- Hepatic irradiation persistently eliminates liver resident NK cells, PLOS ONE, 13(6), 20180613
- Viability of Airborne Tumor Cells during Excision by Ultrasonic Device., Surg Res Pract., 2017
- Effect of Fc-γ Receptor Polymorphism on Rituximab-Mediated B Cell Depletion in ABO-Incompatible Adult Living Donor Liver Transplantation., Transplant Direct., 3(6), e164, 201705
- ★, Significant association between FOXP3 gene polymorphism and steroid-resistant acute rejection in living donor liver transplantation., Hepatol Commun., 1(5), 406-420, 201706
- Effect of bevacizumab plus XELOX (CapeOX) chemotherapy on liver natural killer cell activity in colorectal cancer with resectable liver metastasis, ANNALS OF GASTROENTEROLOGICAL SURGERY, 2(5), 383-393, 201809
- Signal regulatory protein alpha blockade potentiates tumoricidal effects of macrophages on gastroenterological neoplastic cells in syngeneic immunocompetent mice, ANNALS OF GASTROENTEROLOGICAL SURGERY, 2(6), 451-462, 201811
- Memory-like Liver Natural Killer Cells are Responsible for Islet Destruction in Secondary Islet Transplantation, SCIENTIFIC REPORTS, 9, 20190131
- Significant Association Between FOXP3 Gene Polymorphism and Steroid-Resistant Acute Rejection in Living Donor Liver Transplantation, HEPATOLOGY COMMUNICATIONS, 1(5), 406-420, 201707
- Clinical significance of glypican-3-positive circulating tumor cells of hepatocellular carcinoma patients: A prospective study, PLOS ONE, 14(5), 20190529
- Risk Factors for Refractory Ascites After Living Donor Liver Transplant, TRANSPLANTATION PROCEEDINGS, 51(5), 1516-1519, 201906
- Postoperative Portal Hypertension Enhances Alloimmune Responses after Living-Donor Liver Transplantation in Patients and in a Mouse Model, JOURNAL OF IMMUNOLOGY, 203(5), 1392-1403, 20190901
- Management of Refractory Ascites for Liver Transplant Candidates: A Novel Cell-free and Concentrated Ascites Reinfusion Therapy, TRANSPLANTATION PROCEEDINGS, 51(8), 2740-2744, 201910
- Cotransplantation of preactivated mesenchymal stem cells improves intraportal engraftment of islets by inhibiting liver natural killer cells in mice, AMERICAN JOURNAL OF TRANSPLANTATION, 19(10), 2732-2745, 201910
- Utility of Doppler Ultrasonography in Liver Transplantation With Celiac Axis Compression Syndrome: A Case Report, TRANSPLANTATION PROCEEDINGS, 51(9), 3103-3106, 201911
- ★, Everolimus enhances TRAIL-mediated anti-tumor activity of liver resident natural killer cells in mice, TRANSPLANT INTERNATIONAL, 33(2), 229-243, 202002
- Successful Treatment of Chronic Myeloid Leukemia With Dasatinib After Kidney Transplantation: A Case Report, TRANSPLANTATION PROCEEDINGS, 52(2), 600-603, 202003
- Strategies for Deliberate Induction of Immune Tolerance in Liver Transplantation: From Preclinical Models to Clinical Application, FRONTIERS IN IMMUNOLOGY, 11, 20200731
- Impact on biliary complications of donor abdominal aortic calcification among living donor liver transplantation: a retrospective study, TRANSPLANT INTERNATIONAL, 33(12), 1745-1753, 202012
- Analysis of Risk Factors Affecting Incidence of Osteoporosis and Fragility Fractures in Liver Transplant Recipients, ANNALS OF TRANSPLANTATION, 26, 20210205
- Development of a humanized mouse model to analyze antibodies specific for human leukocyte antigen (HLA), PLOS ONE, 16(2), 20210205
- TLR-MyD88 signaling blockades inhibit refractory B-1b cell immune responses to transplant-related glycan antigens, AMERICAN JOURNAL OF TRANSPLANTATION, 21(4), 1427-1439, 202104
- Tumor endothelial cell-mediated antigen-specific T-cell suppression via the PD-1/PD-L1 pathway, Mol Cancer Res., 18(9), 1427-1440, 20200918
- B cell depletion with anti-CD20 mAb exacerbates anti-donor CD4(+) T cell responses in highly sensitized transplant recipients, SCIENTIFIC REPORTS, 11(1), 20210913
- Molecular Mismatch Predicts T Cell-Mediated Rejection and De Novo Donor-Specific Antibody Formation After Living Donor Liver Transplantation, LIVER TRANSPLANTATION, 27(11), 1592-1602, 202111
- Impacts of single nucleotide polymorphisms in Fc gamma receptor IIA (rs1801274) on lung transplant outcomes among Japanese lung transplant recipients, TRANSPLANT INTERNATIONAL, 34(11), 2192-2204, 202111
- Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study, ANNALS OF GASTROENTEROLOGICAL SURGERY, 6(1), 149-158, 202201
- Pilot study to determine the safety and feasibility of deceased donor liver natural killer cell infusion to liver transplant recipients with hepatocellular carcinoma, CANCER IMMUNOLOGY IMMUNOTHERAPY, 71(3), 589-599, 202203
Invited Lecture, Oral Presentation, Poster Presentation
- Current status of desensitization protocol for highly HLA-sensitized kidney transplant candidates, Kentaro Ide, Hiroyuki Tahara, Asuka Tanaka, Shuji Akimoto, Sapana Verma, Lalit Kumar Das, Seiichi Shimizu, Masahiro Ohira, Kohei Ishiyama, Yuka Tanaka, Hideki Ohdan, 2017/02/15, Without Invitation, English
- The Significant Association Between FOXP3 Gene Polymorphism and Severity of Acute Cellular Rejection in Liver Transplantation., Tanaka Y, Verma S, Ohdan H., Asian Transplantation Week 2016, 2016/10/27, Without Invitation, English, Inchon, Korea
- Human endothelial-like cells transdifferentiated from monocytes suppress allo-reactive T cells, Tanaka Y, Ohdan H., 26th International Congress of the Transplantation Society, 2016/08/18, Without Invitation, English, The Transplant Society, Hong Kong, China
- Impact of Immunosuppressants on Inducing Regulatory T Cells in Human Allo-Immune Responses., Tanaka Y, Ohdan H., American Transplant Congress 2016, 2016/06/12, Without Invitation, English, American Transplant Society, Boston, USA
- Monitoring for personalized immune-suppressive therapy., Tanaka Y., Transplantation Science Symposium Asian Regional Meetingb 2016, 2016/04/09, With Invitation, English, The Transplantation Society, Tokyo, Japan
Awards
- 2015/11/11, TTS-JST Transplantation Science Mentee-Mentor Travel Award, The Transplantation Society and the Japan Society for TRansplantation
- 2016/08/18, the TTS-JST Transplantation Science Mentee-Mentor Travel Award, the 26th the International Congress of the Transplantation Society
- 2016/10/24, ATW 2016 Travel Grant
External Funds
Acceptance Results of Competitive Funds
- KAKENHI, The CD47-SIRPa signaling blockade accelerates macrophage phagocytic activity against cancer cells, 2011, 2013
- KAKENHI, Establishment of strategies to regulate antibody-mediated rejection on the basis of B cell differentiation biology, 2011, 2012
- KAKENHI, 2012, 2014
- KAKENHI, 2013, 2014
- KAKENHI, 2015, 2017
- KAKENHI, 2015, 2018
- KAKENHI, 2015, 2017
- KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2020