FARINA BINTI MOHAMAD YUSOFFBINTI MOHAMAD YUSOFF FARINA

Last Updated :2025/07/07

所属・職名
原爆放射線医科学研究所　特任助教
メールアドレス
drfarinamyusoffhiroshima-u.ac.jp
自己紹介
私は 放射線生物学、血管医学、再生医療における微小血管再生、内皮細胞、酸化ストレス、心血管への影響に焦点を当てた基礎研究、橋渡し研究、臨床研究に興味があります。

基本情報

学歴

  • 広島大学, Cardiovascular Regeneration and Medicine, Biomedical and Health Sciences, Japan, 2017年, 2021年

学位

  • 博士（医学）　(広島大学)

研究分野

  • 医歯薬学 / 内科系臨床医学 / 循環器内科学

所属学会

研究活動

学術論文（★は代表的な論文）

  1. A Body Shape Index as a Simple Anthropometric Marker for the Risk of Cardiovascular Events, CURRENT CARDIOLOGY REPORTS, 27巻, 1号, 202512
    DOIを用いた論文検索結果へのリンク
  2. Low-intensity pulsed ultrasound improves symptoms in patients with Buerger disease: a double-blinded, randomized, and placebo-controlled study, SCIENTIFIC REPORTS, 14巻, 1号, 20240614
    DOIを用いた論文検索結果へのリンク
  3. Responses of the carotid artery to acute, fractionated or chronic ionizing irradiation, and differences from the aorta, SCIENTIFIC REPORTS, 15巻, 1号, 20250305
    DOIを用いた論文検索結果へのリンク
  4. Effects of Cumulative Low-Density Lipoprotein Cholesterol Exposure on Endothelial Function in Subjects Receiving Lipid-Lowering Drugs, JACC-ASIA, 5巻, 5号, pp. 691-694, 202505
    DOIを用いた論文検索結果へのリンク
  5. Nighttime blood pressure-targeted antihypertensive treatment, JOURNAL OF HYPERTENSION, 43巻, 5号, pp. 887-896, 202505
    DOIを用いた論文検索結果へのリンク
  6. The relationship between continuation of exercise habit for three years and endothelial function in patients with hypertension, HYPERTENSION RESEARCH, 48巻, 3号, pp. 927-938, 202503
    DOIを用いた論文検索結果へのリンク
  7. Serum uric acid is independently associated with impaired nitroglycerine-induced vasodilation of the brachial artery in women, HYPERTENSION RESEARCH, 48巻, 1号, pp. 6-14, 202501
    DOIを用いた論文検索結果へのリンク
  8. Vascular function assessed by flow-mediated vasodilation and nitroglycerine-induced vasodilation in subjects with first-degree atrioventricular block, SCIENTIFIC REPORTS, 14巻, 1号, 20241205
    DOIを用いた論文検索結果へのリンク
  9. A Body Shape Index as a Simple Anthropometric Marker of Abdominal Obesity and Risk of Cardiovascular Events, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 109巻, 12号, pp. 3272-3281, 20240508
    DOIを用いた論文検索結果へのリンク
  10. New device for assessment of endothelial function: plethysmographic flow-mediated vasodilation (pFMD), HYPERTENSION RESEARCH, 47巻, 9号, pp. 2471-2477, 202409
    DOIを用いた論文検索結果へのリンク
  11. Upstroke time is a more useful marker of atherosclerosis than percentage of mean arterial pressure for detecting coronary artery disease in subjects with a normal ankle-brachial index, HYPERTENSION RESEARCH, 47巻, 8号, pp. 2009-2018, 202408
    DOIを用いた論文検索結果へのリンク
  12. Effects of BNT162b2 mRNA Covid-19 vaccine on vascular function, PLOS ONE, 19巻, 4号, 20240430
    DOIを用いた論文検索結果へのリンク
  13. Association of cumulative low-density lipoprotein cholesterol exposure with vascular function, JOURNAL OF CLINICAL LIPIDOLOGY, 18巻, 2号, pp. e238-e250, 2024
    DOIを用いた論文検索結果へのリンク
  14. Seasonal variations in endothelium-dependent flow-mediated vasodilation and endothelium-independent nitroglycerine-induced vasodilation, HYPERTENSION RESEARCH, 47巻, 4号, pp. 910-920, 202404
    DOIを用いた論文検索結果へのリンク
  15. Role of Small Dense Low-density Lipoprotein Cholesterol in Cardiovascular Events in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus Receiving Statin Treatment, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 31巻, 4号, pp. 478-500, 2024
    DOIを用いた論文検索結果へのリンク
  16. Sparing and enhancing dose protraction effects for radiation damage to the aorta of wild-type mice, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 100巻, 1号, pp. 37-45, 20240102
    DOIを用いた論文検索結果へのリンク
  17. Percentage of mean arterial pressure as a marker of atherosclerosis for detecting patients with coronary artery disease, HYPERTENSION RESEARCH, 47巻, 2号, pp. 281-290, 202402
    DOIを用いた論文検索結果へのリンク
  18. Endothelial Function Is Preserved in Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy, JOURNAL OF CLINICAL MEDICINE, 12巻, 7号, 202304
    DOIを用いた論文検索結果へのリンク
  19. Impact of overnight 1 mg dexamethasone on vascular function in patients with nonfunctioning adrenal adenomas, SCIENTIFIC REPORTS, 13巻, 1号, 20231128
    DOIを用いた論文検索結果へのリンク
  20. Therapeutic Myogenesis Induced by Ultrasound Exposure in a Volumetric Skeletal Muscle Loss Injury Model, AMERICAN JOURNAL OF SPORTS MEDICINE, 51巻, 13号, pp. 3554-3566, 202311
    DOIを用いた論文検索結果へのリンク
  21. KCNJ5mutation is a predictor for recovery of endothelial function after adrenalectomy in patients with aldosterone-producing adenoma, HYPERTENSION RESEARCH, 46巻, 9号, pp. 2213-2227, 202309
    DOIを用いた論文検索結果へのリンク
  22. Effect of exposure to radiation caused by an atomic bomb on endothelial function in atomic bomb survivors, FRONTIERS IN CARDIOVASCULAR MEDICINE, 10巻, 20230217
    DOIを用いた論文検索結果へのリンク
  23. The prevalence of cardiovascular disease is higher in patients with bilateral low ankle-brachial index than in patients with unilateral low ankle-brachial index, ATHEROSCLEROSIS, 360巻, pp. 8-14, 202211
    DOIを用いた論文検索結果へのリンク
  24. Serum Potassium Levels of 4.5 to Less Than 5.0 mmol/L Are Associated with Better Vascular Function, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 29巻, 11号, pp. 1588-1602, 2022
    DOIを用いた論文検索結果へのリンク
  25. Relationship of Daily Coffee Intake with Vascular Function in Patients with Hypertension, NUTRIENTS, 14巻, 13号, 202207
    DOIを用いた論文検索結果へのリンク
  26. Temporal Changes in Sparing and Enhancing Dose Protraction Effects of Ionizing Irradiation for Aortic Damage in Wild-Type Mice, CANCERS, 14巻, 14号, 202207
    DOIを用いた論文検索結果へのリンク
  27. White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation, SCIENTIFIC REPORTS, 12巻, 1号, 20220517
    DOIを用いた論文検索結果へのリンク
  28. Relationship between hemoglobin A1c level and flow-mediated vasodilation in patients with type 2 diabetes mellitus receiving antidiabetic drugs, JOURNAL OF DIABETES INVESTIGATION, 13巻, 4号, pp. 677-686, 202204
    DOIを用いた論文検索結果へのリンク
  29. Self-reported total sitting time on a non-working day is associated with blunted flow-mediated vasodilation and blunted nitroglycerine-induced vasodilation, SCIENTIFIC REPORTS, 12巻, 1号, 20220416
    DOIを用いた論文検索結果へのリンク
  30. Implantation of Hypoxia-Induced Mesenchymal Stem Cell Advances Therapeutic Angiogenesis, STEM CELLS INTERNATIONAL, 2022巻, 20220320
    DOIを用いた論文検索結果へのリンク
  31. Isolated diastolic hypertension is not associated with endothelial dysfunction, HYPERTENSION RESEARCH, 45巻, 4号, pp. 698-707, 202204
    DOIを用いた論文検索結果へのリンク
  32. Poor tooth brushing behavior is associated with high risk of cardiovascular events: A prospective observational study, INTERNATIONAL JOURNAL OF CARDIOLOGY, 350巻, pp. 111-117, 20220301
    DOIを用いた論文検索結果へのリンク
  33. Inconvenient relationship of haemoglobin A1c level with endothelial function in type 2 diabetes in a cross-sectional study, BMJ OPEN, 11巻, 6号, 202106
    DOIを用いた論文検索結果へのリンク
  34. Hematocrit, hemoglobin and red blood cells are associated with vascular function and vascular structure in men, Scientific Reports, 2020
  35. Volume Elastic Modulus, Vascular Function, and Vascular Structure in Patients with Cardiovascular Risk Factors, Journal of Atherosclerosis and Thrombosis, 2020
  36. Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery, Journal of the American Association, 2020
  37. Long-Term Clinical Outcomes of Autologous Bone Marrow Mononuclear Cell Implantation in Patients With Severe Thromboangiitis Obliterans, Circulation Journal, 2020
  38. Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study, BMJ Open, 2020
  39. Hematocrit, hemoglobin and red blood cells are associated with vascular function and vascular structure in men, Scientific Reports, 2020
  40. Increased arterial stiffness and cardiovascular risk prediction in controlled hypertensive patients with coronary artery disease: post hoc analysis of FMD-J (Flow-mediated Dilation Japan) Study A, Hypertension Research, 2020
  41. Vascular function is further impaired in subjects aged 80 years or older, Hypertension Research, 2020
  42. Pre-impaired fasting glucose state is a risk factor for endothelial dysfunction: Flow-mediated Dilation Japan (FMD-J) study, BMJ Open Diabetes Research & Care, 2020
  43. Ionizing Irradiation Induces Vascular Damage in the Aorta of Wild-Type Mice, Cancers (MDPI), 2020
  44. A Comparison of Adrenalectomy and Eplerenone on Vascular Function in Patients with Aldosterone-producing Adenoma, Journal of Clinical Endocrinology & Metabolism, 2020
  45. Relationship between cell number and clinical outcomes of autologous bone-marrow mononuclear cell implantation in critical limb ischemia, Scientific Reports, 2020
  46. Daily Low-intensity Pulsed Ultrasound Ameliorates Renal Fibrosis and Inflammation in Experimental Hypertensive and Diabetic Nephropathy, Hypertension, 2020
  47. Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy, Journal of Clinical Medicine (MDPI), 2020
  48. Smoking status and endothelial function in Japanese men, Scientific Reports, 2021
  49. Association of Body Mass Index with Endothelial Function in Asian Men, International Journal of Cardiology, 2021
  50. Bach1 plays an important role in angiogenesis through regulation of oxidative stress, Microvascular Research, 2021
  51. Short stature is associated with low flow-mediated vasodilation in Japanese men, HYPERTENSION RESEARCH, 45巻, 2号, pp. 308-314, 202202
    DOIを用いた論文検索結果へのリンク
  52. Falsely normalized ankle-brachial index despite the presence of lower-extremity peripheral artery disease: two case reports, JOURNAL OF MEDICAL CASE REPORTS, 15巻, 1号, 20211217
    DOIを用いた論文検索結果へのリンク
  53. Lower triglyceride levels are associated with better endothelial function, Journal of Clinical Lipidology, 2021
  54. Low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia: 5-year follow-up study, PLOS ONE, 16巻, 8号, 2021
    DOIを用いた論文検索結果へのリンク
  55. Volume Elastic Modulus, Vascular Function, and Vascular Structure in Patients with Cardiovascular Risk Factors, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 28巻, 9号, pp. 963-973, 2021
    DOIを用いた論文検索結果へのリンク
  56. A body shape index is associated with endothelial dysfunction in both men and women, SCIENTIFIC REPORTS, 11巻, 1号, 20210909
    DOIを用いた論文検索結果へのリンク
  57. Regenerative medicine for radiation emergencies, JOURNAL OF RADIATION RESEARCH, 62巻, pp. I21-I29, 202104
    DOIを用いた論文検索結果へのリンク
  58. Stair climbing activity and vascular function in patients with hypertension, HYPERTENSION RESEARCH, 44巻, 10号, pp. 1274-1282, 202110
    DOIを用いた論文検索結果へのリンク
  59. Upstroke time as a marker of atherosclerosis in patients with diabetes mellitus who have a normal ankle-brachial index, JOURNAL OF DIABETES AND ITS COMPLICATIONS, 35巻, 11号, 202111
    DOIを用いた論文検索結果へのリンク
  60. Vascular Damage in the Aorta of Wild-Type Mice Exposed to Ionizing Radiation: Sparing and Enhancing Effects of Dose Protraction, CANCERS, 13巻, 21号, 202111
    DOIを用いた論文検索結果へのリンク
  61. Vascular Dysfunction Predicts Future Deterioration of Left Ventricular Ejection Fraction in Patients with Heart Failure with Mildly Reduced Ejection Fraction, JOURNAL OF CLINICAL MEDICINE, 10巻, 24号, 202112
    DOIを用いた論文検索結果へのリンク
  62. Endothelial function is preserved in light to moderate alcohol drinkers but is impaired in heavy drinkers in women: Flow-mediated Dilation Japan (FMD-J) study, PLOS ONE, 2020
  63. Review of the Long-term Effects of Autologous Bone-Marrow Mononuclear Cell Implantation on Clinical Outcomes in Patients with Critical Limb Ischemia, Scientific Reports, 2019
  64. Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension, European Journal of Nutrition, 2019
  65. Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease - Post Hoc Analysis of the FMD-J Study A -, Circulation Journal, 2019
  66. Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study, Journal of Hypertension, 2019
  67. Effects of the Dipeptidyl Peptidase 4 Inhibitor Alogliptin on Blood Pressure in Hypertensive Patients with Type 2 Diabetes Mellitus, American Journal of Hypertension, 2019
  68. Relationships Between Calcium Channel Blockers and Vascular Function Tests, American Journal of Hypertension, 2019
  69. Association of extremely high levels of high-density lipoprotein cholesterol with endothelial dysfunction in men, Journal of Clinical Lipidology, 2019
  70. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study, Scientific Reports, 2019
  71. Relationship between home blood pressure and vascular function in patients receiving antihypertensive drug treatment, Hypertension Research, 2019
  72. Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study, Atherosclerosis, 2018
  73. Chronic kidney disease is associated with vascular smooth muscle dysfunction but not with endothelial dysfunction, International Journal of Cardiology, 2018
  74. Reactive hyperemia-peripheral arterial tonometry is useful for assessment of not only endothelial function but also stenosis of the digital artery, International Journal of Cardiology, 2018
  75. Endothelial dysfunction, abnormal vascular structure and lower urinary tract symptoms in men and women, International Journal of Cardiology, 2018
  76. Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease:FMD-J (Flow-Mediated Dilation Japan) Study A, Journal of the American Heart Association, 2018
  77. New assessment of endothelial function measured by short time flow-mediated vasodilation: Comparison with conventional flow-mediated vasodilation measurement, International Journal of Cardiology, 2018
  78. Autologous mononuclear cells from different sources are seen to improve wound healing in patients with haematological malignancies, The Malaysian journal of pathology, 2018
  79. Microvascular endothelial function is impaired in patients with idiopathic hyperaldosteronism, Hypertension Research, 2018
  80. Interrelationships Among Flow‐Mediated Vasodilation, Nitroglycerine‐Induced Vasodilation, Baseline Brachial Artery Diameter, Hyperemic Shear Stress, and Cardiovascular Risk Factors, Journal of the American Heart Association, 2017
  81. Endothelial function is impaired in patients receiving antihypertensive drug treatment regardless of blood pressure level: FMD-J study (Flow-Mediated Dilation Japan), Hypertension, 2017
  82. Optimal target level of low-density lipoprotein cholesterol for vascular function in statin naïve individuals, Scientific Reports, 2017
  83. Increasing risk of osteoporotic fracture is associated with vascular dysfunction and abnormal vascular structure in both men and women, Circulation Journal, 2017

招待講演、口頭・ポスター発表等

  1. LIPUS FOR NO-OPTION CLTI PATIENT WITH BUERGER DISEASE, Farina Mohamad Yusoff, Masato Kajikawa, Takumi Sakamoto, Akio Tanaka, Takayuki Yamaji, Shinji Kishimoto, Tatsuya Maruhashi and Yukihito Higashi., Vascular Scientific Sessions Presented by the Society for Vascular Medicine 2024, 2024年09月20日, 英語, Society for Vascular Medicine, Houston, Texas, USA
  2. Low-intensity pulsed ultrasound improves symptoms in peripheral arterial disease: a double-blinded, randomized, and placebo- controlled study, Farina Mohamad Yusoff, MBBS, PhD, FSVM, Masato Kajikawa, MD, PhD, Shinji Kishimoto, MD, PhD, Tatsuya Maruhashi, MD, PhD, Ayumu Nakashima, MD, PhD, Toshio Tsuji, PhD, Yukihito Higashi, MD, PhD, FAHA, Vascular Scientific Sessions by Society for Vascular Medicine, 2023年09月08日, 英語, Society for Vascular Medicine, Washington, DC, USA
  3. 血管機能はHFmrEFの心機能低下を予測しうる第, 岸本　真治、丸橋　達也、梶川　正人、原田崇弘、溝渕　亜矢、橋本　悠、Farina Mohamad Yusoff、中野　由紀子、東　幸仁, 第70回日本心臓病学会学術集会, 2022年09月24日, 日本語, 日本心臓病学会
  4. Body Mass Index (BMI)と血管内皮機能との関係, 梶川　正人、丸橋　達也、岸本　真治、山路　貴之、原田　崇弘、橋本　悠、Farina Mohamad Yusoff、Yiming Han、中島　歩、東　幸仁, 第7回日本血管不全学会学術集会, 2022年04月17日, 日本語, 日本血管不全学会
  5. ABI正常の糖尿病患者におけるupstroke timeと心血管疾患の関係についての検討, 丸橋 達也、梶川 正人、岸本 真治、山路 貴之、原田 崇弘、橋本 悠、Farina Mohamad Yusoff、東 幸仁, 第7回日本血管不全学会学術集会, 2022年04月17日, 日本語, 日本血管不全学会
  6. 足首上腕指数が正常な被験者における足首の上昇時間と冠動脈疾患との関連性, 第86回日本循環器学会学術集会, 2022年03月13日, 英語, 日本循環器学会
  7. 体型指数と内皮機能の関係：口蹄疫日本レジストリ, 第86回日本循環器学会学術集会, 2022年03月13日, 日本語, 日本循環器学会
  8. 職業運転手における睡眠呼吸障害の頻度に関する検討, 丸橋 達也、小川 匡彦、福永 保夫、北浦 大作、梶川 正人、岸本 真治、山路 貴之、原田 崇弘、橋本 悠、韓 一鳴、溝渕 亜矢、Yusoff Farina Mohamad、中島 歩、中野 由紀子、東 幸仁, 第43回日本高血圧学会総会, 2021年10月17日, 日本語, 日本高血圧学会
  9. 上腕から足首までの脈波伝播速度は、冠状動脈性心疾患を患い、十分に治療を受けている高血圧患者の心血管リスク評価に役立ちます, 第29回国際高血圧学会学術集会, 2022年10月14日, 英語, 国際高血圧学会
  10. 低体重、過体重、肥満が内皮機能に及ぼす影響: FMD-Japan レジストリ。, 第29回国際高血圧学会学術集会（ISH2022）, 2022年10月16日, 英語, 国際高血圧学会
  11. 野生型マウスにおける大動脈血管損傷に対する放射線量延長の効果の軽減および増強効果。, 第68回放射線学会学術集会。, 2022年10月16日, 英語
  12. 低酸素誘導間葉系幹細胞の移植による治療的血管新生, Vascular Scientific Sessions presented by the Society for Vascular Medicine, 2022年09月30日, 英語, 血管医学会, 米国コロラド州デンバー
  13. 重症虚血肢における自家骨髄単核細胞移植の細胞数と臨床転帰との関係, 2022年08月09日, 英語
  14. 自家骨髄の長期臨床転帰重度の閉塞性血栓血管炎患者における単核球移植, 2022年08月09日, 英語
  15. Bach1 酸化ストレスの調節を通じて血管新生において重要な役割を果たします, ネットワーク型共同利用・放射線災害医科学研究センター 第6回国際シンポジウム ～放射線災害におけるリスクコミュニケーション～危機と復興の時代～, 2022年02月07日, 英語, 構成拠点 (福島医科大学), オンライン
  16. Low-Intensity Pulsed Ultrasound (LIPUS) 重症虚血肢患者の主要な切断を減らす：5年間の追跡調査, 血管内科学会の仮想 SVM 2021 科学セッション, 2021年09月09日, 英語, 血管医学会, オンライン
  17. 重症虚血肢患者の臨床転帰に対する自家骨髄単核細胞移植の長期レビュー, 第83回日本循環器学会学術集会, 2019年03月29日, 英語, 日本循環器学会, 横浜市,日本
  18. 自家骨髄単核細胞移植は、重症虚血肢患者の主要な切断リスクを軽減します：長期転帰レビュー, 第82回日本循環器学会学術集会, 2018年03月23日, 英語, 日本循環器学会, 大阪、日本

受賞

  1. 2022年09月29日, The Alan T Hirsch Travel Award
  2. 2022年03月12日, 第86回日本循環器学会学術集会　循環器再生医科学賞　証明書, 第86回日本循環器学会学術集会
  3. 2021年11月06日, 第125回日本内科学会中国地方会 奨励賞, 第125回日本内科学会中国地方会会長, 高血圧患者の階段の使用と血管機能についての検討
  4. 2021年05月20日, 第21回日本NO学会YIA（TA）候補セッション 優秀賞, 日本NO学会理事長/第21回日本NO学会会長, 空腹時血糖値 95-99 mg/dL は血管内皮機能障害のリスクである