BINTI MOHAMAD YUSOFF FARINA

Last Updated :2025/06/16

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Assistant Professor (Special Appointment)
E-mail
drfarinamyusoffhiroshima-u.ac.jp
Self-introduction
I am interested in basic, translational and clinical studies focusing on microvascular regeneration, endothelial cell, oxidative stress and cardiovascular effects in radiation biology, vascular medicine and regenerative medicine.

Basic Information

Educational Backgrounds

  • Hiroshima University, Cardiovascular Regeneration and Medicine, Biomedical and Health Sciences, Japan, 2017, 2021

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Cardiovascular medicine

Affiliated Academic Societies

Research Activities

Academic Papers

  1. A Body Shape Index as a Simple Anthropometric Marker for the Risk of Cardiovascular Events, CURRENT CARDIOLOGY REPORTS, 27(1), 202512
    Link to Paper Search Results by DOI
  2. Low-intensity pulsed ultrasound improves symptoms in patients with Buerger disease: a double-blinded, randomized, and placebo-controlled study, SCIENTIFIC REPORTS, 14(1), 20240614
    Link to Paper Search Results by DOI
  3. Responses of the carotid artery to acute, fractionated or chronic ionizing irradiation, and differences from the aorta, SCIENTIFIC REPORTS, 15(1), 20250305
    Link to Paper Search Results by DOI
  4. Effects of Cumulative Low-Density Lipoprotein Cholesterol Exposure on Endothelial Function in Subjects Receiving Lipid-Lowering Drugs, JACC-ASIA, 5(5), 691-694, 202505
    Link to Paper Search Results by DOI
  5. Nighttime blood pressure-targeted antihypertensive treatment, JOURNAL OF HYPERTENSION, 43(5), 887-896, 202505
    Link to Paper Search Results by DOI
  6. The relationship between continuation of exercise habit for three years and endothelial function in patients with hypertension, HYPERTENSION RESEARCH, 48(3), 927-938, 202503
    Link to Paper Search Results by DOI
  7. Serum uric acid is independently associated with impaired nitroglycerine-induced vasodilation of the brachial artery in women, HYPERTENSION RESEARCH, 48(1), 6-14, 202501
    Link to Paper Search Results by DOI
  8. Vascular function assessed by flow-mediated vasodilation and nitroglycerine-induced vasodilation in subjects with first-degree atrioventricular block, SCIENTIFIC REPORTS, 14(1), 20241205
    Link to Paper Search Results by DOI
  9. A Body Shape Index as a Simple Anthropometric Marker of Abdominal Obesity and Risk of Cardiovascular Events, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 109(12), 3272-3281, 20240508
    Link to Paper Search Results by DOI
  10. New device for assessment of endothelial function: plethysmographic flow-mediated vasodilation (pFMD), HYPERTENSION RESEARCH, 47(9), 2471-2477, 202409
    Link to Paper Search Results by DOI
  11. Upstroke time is a more useful marker of atherosclerosis than percentage of mean arterial pressure for detecting coronary artery disease in subjects with a normal ankle-brachial index, HYPERTENSION RESEARCH, 47(8), 2009-2018, 202408
    Link to Paper Search Results by DOI
  12. Effects of BNT162b2 mRNA Covid-19 vaccine on vascular function, PLOS ONE, 19(4), 20240430
    Link to Paper Search Results by DOI
  13. Association of cumulative low-density lipoprotein cholesterol exposure with vascular function, JOURNAL OF CLINICAL LIPIDOLOGY, 18(2), e238-e250, 2024
    Link to Paper Search Results by DOI
  14. Seasonal variations in endothelium-dependent flow-mediated vasodilation and endothelium-independent nitroglycerine-induced vasodilation, HYPERTENSION RESEARCH, 47(4), 910-920, 202404
    Link to Paper Search Results by DOI
  15. Role of Small Dense Low-density Lipoprotein Cholesterol in Cardiovascular Events in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus Receiving Statin Treatment, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 31(4), 478-500, 2024
    Link to Paper Search Results by DOI
  16. Sparing and enhancing dose protraction effects for radiation damage to the aorta of wild-type mice, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 100(1), 37-45, 20240102
    Link to Paper Search Results by DOI
  17. Percentage of mean arterial pressure as a marker of atherosclerosis for detecting patients with coronary artery disease, HYPERTENSION RESEARCH, 47(2), 281-290, 202402
    Link to Paper Search Results by DOI
  18. Endothelial Function Is Preserved in Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy, JOURNAL OF CLINICAL MEDICINE, 12(7), 202304
    Link to Paper Search Results by DOI
  19. Impact of overnight 1 mg dexamethasone on vascular function in patients with nonfunctioning adrenal adenomas, SCIENTIFIC REPORTS, 13(1), 20231128
    Link to Paper Search Results by DOI
  20. Therapeutic Myogenesis Induced by Ultrasound Exposure in a Volumetric Skeletal Muscle Loss Injury Model, AMERICAN JOURNAL OF SPORTS MEDICINE, 51(13), 3554-3566, 202311
    Link to Paper Search Results by DOI
  21. KCNJ5mutation is a predictor for recovery of endothelial function after adrenalectomy in patients with aldosterone-producing adenoma, HYPERTENSION RESEARCH, 46(9), 2213-2227, 202309
    Link to Paper Search Results by DOI
  22. Effect of exposure to radiation caused by an atomic bomb on endothelial function in atomic bomb survivors, FRONTIERS IN CARDIOVASCULAR MEDICINE, 10, 20230217
    Link to Paper Search Results by DOI
  23. The prevalence of cardiovascular disease is higher in patients with bilateral low ankle-brachial index than in patients with unilateral low ankle-brachial index, ATHEROSCLEROSIS, 360, 8-14, 202211
    Link to Paper Search Results by DOI
  24. Serum Potassium Levels of 4.5 to Less Than 5.0 mmol/L Are Associated with Better Vascular Function, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 29(11), 1588-1602, 2022
    Link to Paper Search Results by DOI
  25. Relationship of Daily Coffee Intake with Vascular Function in Patients with Hypertension, NUTRIENTS, 14(13), 202207
    Link to Paper Search Results by DOI
  26. Temporal Changes in Sparing and Enhancing Dose Protraction Effects of Ionizing Irradiation for Aortic Damage in Wild-Type Mice, CANCERS, 14(14), 202207
    Link to Paper Search Results by DOI
  27. White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation, SCIENTIFIC REPORTS, 12(1), 20220517
    Link to Paper Search Results by DOI
  28. Relationship between hemoglobin A1c level and flow-mediated vasodilation in patients with type 2 diabetes mellitus receiving antidiabetic drugs, JOURNAL OF DIABETES INVESTIGATION, 13(4), 677-686, 202204
    Link to Paper Search Results by DOI
  29. Self-reported total sitting time on a non-working day is associated with blunted flow-mediated vasodilation and blunted nitroglycerine-induced vasodilation, SCIENTIFIC REPORTS, 12(1), 20220416
    Link to Paper Search Results by DOI
  30. Implantation of Hypoxia-Induced Mesenchymal Stem Cell Advances Therapeutic Angiogenesis, STEM CELLS INTERNATIONAL, 2022, 20220320
    Link to Paper Search Results by DOI
  31. Isolated diastolic hypertension is not associated with endothelial dysfunction, HYPERTENSION RESEARCH, 45(4), 698-707, 202204
    Link to Paper Search Results by DOI
  32. Poor tooth brushing behavior is associated with high risk of cardiovascular events: A prospective observational study, INTERNATIONAL JOURNAL OF CARDIOLOGY, 350, 111-117, 20220301
    Link to Paper Search Results by DOI
  33. Inconvenient relationship of haemoglobin A1c level with endothelial function in type 2 diabetes in a cross-sectional study, BMJ OPEN, 11(6), 202106
    Link to Paper Search Results by DOI
  34. Hematocrit, hemoglobin and red blood cells are associated with vascular function and vascular structure in men, Scientific Reports, 2020
  35. Volume Elastic Modulus, Vascular Function, and Vascular Structure in Patients with Cardiovascular Risk Factors, Journal of Atherosclerosis, 2020
  36. Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery, Journal of the American Association, 2020
  37. Long-Term Clinical Outcomes of Autologous Bone Marrow Mononuclear Cell Implantation in Patients With Severe Thromboangiitis Obliterans, Circulation Journal, 2020
  38. Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study, BMJ Open, 2020
  39. Hematocrit, hemoglobin and red blood cells are associated with vascular function and vascular structure in men, Scientific Reports, 2020
  40. Increased arterial stiffness and cardiovascular risk prediction in controlled hypertensive patients with coronary artery disease: post hoc analysis of FMD-J (Flow-mediated Dilation Japan) Study A, Hypertension Research, 2020
  41. Vascular function is further impaired in subjects aged 80 years or older, Hypertension Research, 2020
  42. Pre-impaired fasting glucose state is a risk factor for endothelial dysfunction: Flow-mediated Dilation Japan (FMD-J) study, BMJ Open Diabetes Research & Care, 2020
  43. Ionizing Irradiation Induces Vascular Damage in the Aorta of Wild-Type Mice, Cancers (MDPI), 2020
  44. A Comparison of Adrenalectomy and Eplerenone on Vascular Function in Patients with Aldosterone-producing Adenoma, Journal of Clinical Endocrinology & Metabolism, 2020
  45. Relationship between cell number and clinical outcomes of autologous bone-marrow mononuclear cell implantation in critical limb ischemia, Scientific Reports, 2020
  46. Daily Low-intensity Pulsed Ultrasound Ameliorates Renal Fibrosis and Inflammation in Experimental Hypertensive and Diabetic Nephropathy, Hypertension, 2020
  47. Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy, Journal of Clinical Medicine (MDPI), 2020
  48. Smoking status and endothelial function in Japanese men, Scientific Reports, 2021
  49. Association of Body Mass Index with Endothelial Function in Asian Men, International Journal of Cardiology, 2021
  50. Bach1 plays an important role in angiogenesis through regulation of oxidative stress, Microvascular Research, 2021
  51. Short stature is associated with low flow-mediated vasodilation in Japanese men, HYPERTENSION RESEARCH, 45(2), 308-314, 202202
    Link to Paper Search Results by DOI
  52. Falsely normalized ankle-brachial index despite the presence of lower-extremity peripheral artery disease: two case reports, JOURNAL OF MEDICAL CASE REPORTS, 15(1), 20211217
    Link to Paper Search Results by DOI
  53. Lower triglyceride levels are associated with better endothelial function, Journal of Clinical Lipidology, 2021
  54. Low-intensity pulsed ultrasound decreases major amputation in patients with critical limb ischemia: 5-year follow-up study, PLOS ONE, 16(8), 2021
    Link to Paper Search Results by DOI
  55. Volume Elastic Modulus, Vascular Function, and Vascular Structure in Patients with Cardiovascular Risk Factors, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 28(9), 963-973, 2021
    Link to Paper Search Results by DOI
  56. A body shape index is associated with endothelial dysfunction in both men and women, SCIENTIFIC REPORTS, 11(1), 20210909
    Link to Paper Search Results by DOI
  57. Regenerative medicine for radiation emergencies, JOURNAL OF RADIATION RESEARCH, 62, I21-I29, 202104
    Link to Paper Search Results by DOI
  58. Stair climbing activity and vascular function in patients with hypertension, HYPERTENSION RESEARCH, 44(10), 1274-1282, 202110
    Link to Paper Search Results by DOI
  59. Upstroke time as a marker of atherosclerosis in patients with diabetes mellitus who have a normal ankle-brachial index, JOURNAL OF DIABETES AND ITS COMPLICATIONS, 35(11), 202111
    Link to Paper Search Results by DOI
  60. Vascular Damage in the Aorta of Wild-Type Mice Exposed to Ionizing Radiation: Sparing and Enhancing Effects of Dose Protraction, CANCERS, 13(21), 202111
    Link to Paper Search Results by DOI
  61. Vascular Dysfunction Predicts Future Deterioration of Left Ventricular Ejection Fraction in Patients with Heart Failure with Mildly Reduced Ejection Fraction, JOURNAL OF CLINICAL MEDICINE, 10(24), 202112
    Link to Paper Search Results by DOI
  62. Endothelial function is preserved in light to moderate alcohol drinkers but is impaired in heavy drinkers in women: Flow-mediated Dilation Japan (FMD-J) study, PLOS ONE, 2020
  63. Review of the Long-term Effects of Autologous Bone-Marrow Mononuclear Cell Implantation on Clinical Outcomes in Patients with Critical Limb Ischemia, Scientific Reports, 2019
  64. Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension, European Journal of Nutrition, 2019
  65. Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease - Post Hoc Analysis of the FMD-J Study A -, Circulation Journal, 2019
  66. Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study, Journal of Hypertension, 2019
  67. Effects of the Dipeptidyl Peptidase 4 Inhibitor Alogliptin on Blood Pressure in Hypertensive Patients with Type 2 Diabetes Mellitus, American Journal of Hypertension, 2019
  68. Relationships Between Calcium Channel Blockers and Vascular Function Tests, American Journal of Hypertension, 2019
  69. Association of extremely high levels of high-density lipoprotein cholesterol with endothelial dysfunction in men, Journal of Clinical Lipidology, 2019
  70. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study, Scientific Reports, 2019
  71. Relationship between home blood pressure and vascular function in patients receiving antihypertensive drug treatment, Hypertension Research, 2019
  72. Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study, Atherosclerosis, 2018
  73. Chronic kidney disease is associated with vascular smooth muscle dysfunction but not with endothelial dysfunction, International Journal of Cardiology, 2018
  74. Reactive hyperemia-peripheral arterial tonometry is useful for assessment of not only endothelial function but also stenosis of the digital artery, International Journal of Cardiology, 2018
  75. Endothelial dysfunction, abnormal vascular structure and lower urinary tract symptoms in men and women, International Journal of Cardiology, 2018
  76. Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease:FMD-J (Flow-Mediated Dilation Japan) Study A, Journal of the American Heart Association, 2018
  77. New assessment of endothelial function measured by short time flow-mediated vasodilation: Comparison with conventional flow-mediated vasodilation measurement, International Journal of Cardiology, 2018
  78. Autologous mononuclear cells from different sources are seen to improve wound healing in patients with haematological malignancies, The Malaysian journal of pathology, 2018
  79. Microvascular endothelial function is impaired in patients with idiopathic hyperaldosteronism, Hypertension Research, 2018
  80. Interrelationships Among Flow-Mediated Vasodilation, Nitroglycerine-Induced Vasodilation, Baseline Brachial Artery Diameter, Hyperemic Shear Stress, and Cardiovascular Risk Factors, Journal of the American Heart Association, 2017
  81. Endothelial function is impaired in patients receiving antihypertensive drug treatment regardless of blood pressure level: FMD-J study (Flow-Mediated Dilation Japan), Hypertension, 2017
  82. Optimal target level of low-density lipoprotein cholesterol for vascular function in statin naïve individuals, Scientific Reports, 2017
  83. Increasing risk of osteoporotic fracture is associated with vascular dysfunction and abnormal vascular structure in both men and women, Circulation Journal, 2017

Invited Lecture, Oral Presentation, Poster Presentation

  1. LIPUS FOR NO-OPTION CLTI PATIENT WITH BUERGER DISEASE, Farina Mohamad Yusoff, Masato Kajikawa, Takumi Sakamoto, Akio Tanaka, Takayuki Yamaji, Shinji Kishimoto, Tatsuya Maruhashi and Yukihito Higashi., Vascular Scientific Sessions Presented by the Society for Vascular Medicine 2024, 2024/09/20, English, Society for Vascular Medicine, Houston, Texas, USA
  2. Low-intensity pulsed ultrasound improves symptoms in peripheral arterial disease: a double-blinded, randomized, and placebo- controlled study, Farina Mohamad Yusoff, MBBS, PhD, FSVM, Masato Kajikawa, MD, PhD, Shinji Kishimoto, MD, PhD, Tatsuya Maruhashi, MD, PhD, Ayumu Nakashima, MD, PhD, Toshio Tsuji, PhD, Yukihito Higashi, MD, PhD, FAHA, Vascular Scientific Sessions by Society for Vascular Medicine, 2023/09/08, English, Society for Vascular Medicine, Washington, DC, USA
  3. Vascular function may predict cardiac function decline in HFmrEF, The 70th Annual Meeting of the Japanese College of Cardiology, 2022/09/24, Japanese, Japanese College of Cardiology, Kyoto, Japan
  4. Relationship between Body Mass Index (BMI) and vascular endothelial function, The 7th Annual Meeting of the Japanese Society for Vascular Insufficiency, 2022/04/17, Japanese, Japanese Society for Vascular Insufficiency
  5. Study on the relationship between upstroke time and cardiovascular disease in diabetic patients with normal ABI, The 7th Annual Meeting of the Japanese Society for Vascular Insufficiency, 2022/04/17, Japanese, Japanese Society for Vascular Insufficiency, Osaka, Japan
  6. Association between Upstroke Time at the Ankle and Coronary Artery Disease among Subjects with Normal Ankle-brachial Index, Tatsuya Maruhashi, Masato Kajikawa, Shinji Kishimoto, Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Farina Mohamad Yusoff, Yukiko Nakano, Yukihito Higashi, The 86th Annual Meeting of the Japanese Circulation Society, 2022/03/13, English, Online conference
  7. Relationship between a Body Shape Index and Endothelial Function: FMD-Japan Registry, Masato Kajikawa, Tatsuya Maruhashi, Shinji Kishimoto, Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Yiming Han, Farina Mohamad Yusoff, Ayumu Nakashima, Yukihito Higashi., The 86th Annual Meeting of the Japanese Circulation Society, 2022/03/13, Japanese
  8. A study on the frequency of sleep-disordered breathing in professional drivers, The 43rd Annual Meeting of the Japanese Society of Hypertension, 2021/10/17, Japanese, Japanese Society of Hypertension, Okinawa, Japan
  9. Brachial-ankle pulse wave velocity is useful for cardiovascular risk assessment in well-treated hypertensive patients with coronary heart disease, Tatsuya Maruhashi, Masato Kajikawa, Shinji Kishimoto, Takahiro Harada, Yu Hashimoto, Farina Mohamad Yusoff, Yukiko Nakano, Ayumu Nakashima, Bonpei Takase, Hirofumi Tomiyama, Akira Yamashina, Yukihito Higashi, The 29th Scientific Meeting of the International Society of Hypertension, 2022/10/14, English, International Society of Hypertension
  10. Impact of underweight, overweight, and obesity on endothelial function: FMD-Japan registry., Masato Kajikawa, Tatsuya Maruhashi, Shinji Kishimoto, Takahiro Harada, Yu Hashimoto, Aya Mizobuchi, Yiming Han, Farina Mohamad Yusoff, Ayumu Nakashima, Yukihito Higashi., The 29th Scientific Meeting of the International Society of Hypertension (ISH2022), 2022/10/16, English, International Society of Hypertension, Kyoto, Japan
  11. Sparing and enhancing effects of radiation dose protraction for aortic vascular damage in wild-type mice., Nobuyuki Hamada, Ki-ichiro Kawano, Takaharu Nomura, Kyoji Furukawa, Farina Mohamad Yusoff, Tatsuya Maruhashi, Makoto Maeda, Ayumu Nakashima, Yukihito Higashi., The 68th Annual Meeting of the Radiation Research Society., 2022/10/16, English, Radiation Research Society, Hawaii, USA.
  12. Therapeutic Angiogenesis With Implantation of Hypoxia-induced Mesenchymal Stem Cell, Vascular Scientific Sessions presented by the Society for Vascular Medicine, 2022/09/30, English, Society for Vascular Medicine, Denver, Colorado, USA
  13. Relationship between cell number and clinical outcomes of autologous bone marrow mononuclear cell implantation in critical limb ischemia, The virtual conference 19th Malaysian Society of Haematology Annual Scientific Meeting 2022, 2022/08/09, English, Malaysian Society of Haematology, Online
  14. Long-term clinical outcomes of autologous bone marrow mononuclear cell implantation in patients with severe thromboangiitis obliterans, The virtual conference 19th Malaysian Society of Haematology Annual Scientific Meeting 2022, 2022/08/09, English, Malaysian Society of Haematology, Online
  15. Bach1 plays an important role in angiogenesis through regulation of oxidative stress, The 6th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science - Risk Communication in Radiation Disaster – During Crisis and Reconstruction, 2022/02/07, English, Network-type Joint Usage/Research Center (Fukushima Medical University), Online
  16. Low-Intensity Pulsed Ultrasound (LIPUS) Decreases Major Amputation in Patients with Critical Limb Ischemia: 5-Year Follow-Up Study, Virtual SVM 2021 Scientific Sessions of the Society for Vascular Medicine, 2021/09/09, English, Society for Vascular Medicine, Online
  17. A Long-term Review of the Autologous Bone-Marrow Mononuclear Cells Implantation on Clinical Outcomes in Patients with Critical Limb Ischemia, The 83rd Annual Scientific Meeting of the Japanese Circulation Society, 2019/03/29, English, The Japanese Circulation Society, Yokohama, Japan
  18. Autologous Bone-Marrow Mononuclear Cells Implantation Reduces Major Amputation Risk in Patients with Critical Limb Ischemia: A Long-Term Outcome Review, The 82nd Annual Scientific Meeting of the Japanese Circulation Society, 2018/03/23, English, The Japanese Circulation Society, Osaka, Japan

Awards

  1. 2022/09/29, The Alan T Hirsch Travel Award, Society for Vascular Medicine, The Vascular Scientific Sessions presented by the Society for Vascular Medicine
  2. 2022/03/12, Annual Meeting of the Japanese Circulation Society Cardiology Regenerative Medicine Award Certificate, 86th Annual Meeting of the Japanese Circulation Society, Japanese Circulation Society