神沼 修OSAMU KAMINUMA

Last Updated :2022/12/02

所属・職名
原爆放射線医科学研究所 教授
メールアドレス
okamihiroshima-u.ac.jp
自己紹介
放射線医学をはじめ、さまざまな疾患の治療法開発に役立つ技術開発に挑んでいます

基本情報

主な職歴

  • 2019年04月01日, 広島大学, 原爆放射線医科学研究所, 教授
  • 2016年04月01日, 2019年03月31日, 山梨大学, 総合分析実験センター, 准教授
  • 2012年04月01日, 2016年03月31日, 東京都医学総合研究所, 花粉症プロジェクト, 主任研究員
  • 2006年04月01日, 2012年03月31日, 東京都臨床医学総合研究所, 花粉症プロジェクト, 主任研究員
  • 2001年06月01日, 2006年03月31日, 東京都臨床医学総合研究所, 免疫研究部門, 研究員
  • 1998年08月01日, 2000年01月31日, La Jolla Institute for Allergy and Immunology, Division of Cell Biology, Visiting Fellow
  • 1990年04月01日, 2001年05月31日, 田辺製薬株式会社, 生物研究所, 研究員

学歴

  • 東京大学, 農学部, 獣医学科, 1984年04月, 1990年03月

学位

  • 博士(獣医学) (東京大学)

教育担当

  • 【学士課程】 医学部 : 医学科 : 医学プログラム
  • 【博士課程前期】 医系科学研究科 : 総合健康科学専攻 : 生命医療科学プログラム
  • 【博士課程後期】 医系科学研究科 : 総合健康科学専攻 : 生命医療科学プログラム
  • 【博士課程】 医系科学研究科 : 医歯薬学専攻 : 放射線医科学専門プログラム

研究分野

  • 農学 / 動物生命科学 / 獣医学
  • 医歯薬学 / 基礎医学 / 免疫学
  • 農学 / 境界農学 / 応用分子細胞生物学
  • 医歯薬学 / 薬学 / 生物系薬学

研究キーワード

  • 実験動物学、免疫学、遺伝子改変、体細胞クローン、人工染色体、T細胞、アレルギー

所属学会

  • 日本実験動物学会(評議員)
  • 日本免疫学会(評議員)
  • 日本アレルギー学会(代議員)
  • 日本生化学会(評議員)
  • 日本薬理学会(学術評議員、認定薬理学エデュケータ-)
  • アレルギー・好酸球研究会(幹事)
  • 中国地区放射線影響研究会(世話人)
  • 日本放射線影響学会
  • 日本獣医学会
  • 日本実験動物医学会
  • 日本医科大学医学会
  • 日本アレルギー協会
  • The American Association of Immunologists
  • The American Society for Biochemistry and Molecular Biology

教育活動

授業担当

  1. 2022年, 教養教育, 1ターム, 初修生物学(受講場所:東広島キャンパス)
  2. 2022年, 教養教育, 1ターム, 初修生物学(受講場所:霞キャンパス)[1医,1歯,1薬]
  3. 2022年, 学部専門, 集中, 医学研究実習
  4. 2022年, 学部専門, 2ターム, 免疫学概論
  5. 2022年, 修士課程・博士課程前期, セメスター(前期), 特別演習
  6. 2022年, 修士課程・博士課程前期, セメスター(後期), 特別演習
  7. 2022年, 修士課程・博士課程前期, セメスター(前期), 特別研究
  8. 2022年, 修士課程・博士課程前期, セメスター(後期), 特別研究
  9. 2022年, 博士課程・博士課程後期, セメスター(前期), 特別演習
  10. 2022年, 博士課程・博士課程後期, セメスター(後期), 特別演習
  11. 2022年, 博士課程・博士課程後期, セメスター(前期), 特別研究
  12. 2022年, 博士課程・博士課程後期, セメスター(後期), 特別研究
  13. 2022年, 博士課程・博士課程後期, セメスター(前期), 疾患モデル解析学特別演習
  14. 2022年, 博士課程・博士課程後期, セメスター(後期), 疾患モデル解析学特別演習
  15. 2022年, 博士課程・博士課程後期, セメスター(前期), 疾患モデル解析学特別研究
  16. 2022年, 博士課程・博士課程後期, セメスター(後期), 疾患モデル解析学特別研究
  17. 2022年, 博士課程・博士課程後期, セメスター(後期), 放射線生物学入門

研究活動

学術論文(★は代表的な論文)

  1. Suppressive Effect of Lactococcus lactis subsp. cremoris YRC3780 on a Murine Model of Japanese Cedar Pollinosis., Pathogens, 11巻, pp. 1347, 202211
  2. Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness, Journal of Pharmacological Sciences, 150巻, 4号, pp. 275-278, 202210
  3. 舌下免疫療法のメカニズム解明-臨床研究からわかったこと-, アロス エルゴン, 2巻, 3号, pp. 687-695, 202209
  4. BACH1 promotes clear cell renal cell carcinoma progression via upregulating oxidative stress-related tumorigenicity., Cancer Science, 202209
  5. L-type amino acid transporter 1(LAT1)特異的阻害薬による難治性気管支喘息治療の可能性, 日薬理誌, 157巻, pp. 305-309, 202209
  6. 重症喘息のステロイド抵抗性とその制御, 日薬理誌, 157巻, pp. 293-298, 202209
  7. DDX41 expression is associated with tumor necrosis in clear cell renal cell carcinoma and in cooperation with VHL loss leads to worse prognosis., Urologic Oncology, 40巻, 10号, pp. 456.e9-456.e18, 202207
  8. Th17-Dependent Nasal Hyperresponsiveness Is Mitigated by Steroid Treatment, BIOMOLECULES, 12巻, 5号, 202205
  9. Regulation of Th2 responses by Lactococcus lactis subsp. cremoris YRC3780 alleviates DNCB-induced atopic dermatitis in the mouse model, JOURNAL OF FUNCTIONAL FOODS, 94巻, 202207
  10. アレルゲン免疫療法の好塩基球を介した奏功機構, アレルギーの臨床, 42巻, pp. 52-55, 2022
  11. Therapeutic Potential for Intractable Asthma by Targeting L-Type Amino Acid Transporter 1, BIOMOLECULES, 12巻, 4号, 202204
  12. Expression and function of nicotinic acetylcholine receptors in induced regulatory T cells, International Journal of Molecular Sciences, 23巻, pp. 1779, 2022
  13. Suppressive effect of dexamethasone on murine Th9 cell-mediated nasal eosinophlic inflammation, ASIA PACIFIC ALLERGY, 11巻, 3号, 202107
  14. L-type amino acid transporter 1 inhibitor suppresses murine Th2 cell-mediated bronchial hyperresponsiveness independently of eosinophil accumulation, ASIA PACIFIC ALLERGY, 11巻, 3号, 202107
  15. Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22巻, 5号, 202103
  16. Sublingual Immunotherapy: How Sublingual Allergen Administration Heals Allergic Diseases; Current Perspective about the Mode of Action, PATHOGENS, 10巻, 2号, 202102
  17. Progress of genome editing technology and developmental biology useful for radiation research, Journal of Radiation Research, 62巻, pp. i53-i63, 2021
  18. T細胞依存的アレルギー性炎症の臓器・サブセット特異的な薬剤応答性, アレルギーの臨床, 41巻, 2号, pp. 80-83, 2021
  19. Sublingual immunotherapy: how sublingual allergen administration heals allergic diseases; current perspective about the mode of action, Pathogens, 10巻, 2号, pp. 147, 2021
  20. Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development, International Journal of Molecular Science, 22巻, pp. 2725, 2021
  21. Suppressive effect of dexamethasone on murine Th9 cell-mediated nasal eosinophilic inflammation, Asia Pacific Allergy, 11巻, pp. e25, 2021
  22. L-type amino acid transporter 1 inhibitor suppresses murine Th2 cell-mediated bronchial hyperresponsiveness independently of eosinophil accumulation, Asia Pacific Allergy, 11巻, pp. e33, 202107
  23. Role of CD4(+) T Cells in Allergic Airway Diseases: Learning from Murine Models, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21巻, 20号, 202010
  24. Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression, JOURNAL OF MEDICAL INVESTIGATION, 67巻, 3-4号, pp. 289-297, 202008
  25. Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction, CLINICAL CANCER RESEARCH, 26巻, 8号, pp. 2065-2079, 202004
  26. Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation, ASIA PACIFIC ALLERGY, 10巻, 2号, 202004
  27. Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production, INTERNATIONAL IMMUNOLOGY, 32巻, 3号, pp. 187-201, 202003
  28. LAT1-specific inhibitor is effective against T cell-mediated allergic skin inflammation, ALLERGY, 75巻, 2号, pp. 463-467, 202002
  29. Association of Basophil-Expressing Genes with Effectiveness of Sublingual Immunotheraphy, JOURNAL OF NIPPON MEDICAL SCHOOL, 87巻, 1号, pp. 49-52, 202002
  30. Identification of novel interacting regions involving calcineurin and nuclear factor of activated T cells, FASEB JOURNAL, 34巻, 2号, pp. 3197-3208, 202002
  31. T Cell-Mediated Nasal Hyperresponsiveness in Allergic Rhinitis, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 43巻, 1号, pp. 36-40, 202001
  32. LAT1-specific inhibitor is effective against T cell-mediated allergic skin inflammation., Allergy, 75巻, pp. 463-467, 2020
  33. Basophil-expressing genes related with the efficacy of sublingual immunotherapy., Journal of Nippon Medical School, 87巻, 49-52号, 2020
  34. T cell-mediated nasal hyperresponsiveness in allergic rhinitis., Biological and Pharmaceutical Bulletin, 43巻, pp. 36-40, 2020
  35. Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production., International Immunology, 32巻, pp. 187-201, 2020
  36. L-type amino acid transporter 1 (LAT1)-specific inhibitor is effective against T cell-mediated nasal hyperresponsiveness., Allergology International, 69巻, 3号, pp. 455-458, 2020
  37. Identification of novel interacting regions involving calcineurin and nuclear factor of activated T cells., FASEB Journal, 34巻, pp. 3197-3208, 2020
  38. Kdm6a deficiency activates inflammatory pathways, promotes M2 macrophage polarization and causes bladder cancer in cooperation with p53 dysfunction., Clinical Cancer Research, 26巻, 8号, pp. 2065-2079, 2020
  39. 皮膚アレルギー研究に役立つ新しいマウスモデル, 臨床免疫・アレルギー科, 73巻, 5号, pp. 506-512, 2020
  40. Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation, Asia Pacific Allergy, 10巻, 2号, pp. e18, 2020
  41. Epicutaneous allergen administration without antigen delivery device induces local T cell response and alleviates food allergic enteropathy., Allergology International, 69巻, pp. 622-625, 2020
  42. Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression, Journal of Medical Investigation, 67巻, 3-4号, pp. 289-297, 2020
  43. マウスTh9 細胞移入喘息モデルの解析からみえてきた新たな気道過敏性亢進機構, 日本薬理学雑誌, 155巻, pp. 375-380, 2020
  44. Role of CD4+ T Cells in Allergic Airway Diseases: Learning from Murine Models, International Journal of Molecular Science, 21巻, 20号, pp. 7480, 2020
  45. 転写因子NFATファミリーにおけるアイソフォーム選択的制御の意義と可能性, 生化学, 92巻, 6号, pp. 783-790, 2020
  46. Thrombospondin 1-mediated suppression of mast cell degranulation is involved in the efficacy of sublingual immunotherapy., Allergology International, 68巻, pp. S9-10, 2019
  47. Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness., International Journal of Molecular Sciences, 20巻, pp. 2980, 2019
  48. 統合比較解析で見えてきたアレルゲン免疫療法の作用メカニズム, 日本薬理学雑誌, 154号, pp. 23-27, 2019
  49. T-Helper Type 2 Cells Direct Antigen-Induced Eosinophilic Skin Inflammation in Mice., Allergy, Asthma & Immunology Research, 10巻, pp. 77-82, 2018
  50. Down-regulation of NFAT3 due to lack of T-box transcription factor TBX5 is crucial for cytokine expression in T cells., Journal of Immunology, 200巻, pp. 92-100, 2018
  51. Contribution of neuraminidase 3 to the differentiation of induced regulatory T cells., Genes to Cells, 23巻, pp. 112-116, 2018
  52. Involvement of taste receptors in the effectiveness of sublingual immunotherapy., Allergology International, 67巻, pp. 421-424, 2018
  53. Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis., Allergology International, 67巻, pp. S25-31, 2018
  54. Microarray-Based Multivariate Analysis of the Effectiveness of Sublingual Immunotherapy for Cedar Pollinosis., Allergy, Asthma & Immunology Research, 10巻, pp. 562-569, 2018
  55. Serum Cytokine Interactions Are Implicated in the Mechanism of Action of Sublingual Immunotherapy for Japanese Cedar Pollinosis., Journal of Nippon Medical School, 85巻, pp. 250-258, 2018
  56. 鼻粘膜過敏性によるアレルギー性鼻炎病態評価の重要性., アレルギーの臨床, 38号, pp. 884-889, 2018
  57. T細胞依存性マウス気管支喘息モデルを用いた基礎研究からの提言, アレルギーの臨床, 38号, pp. 461-466, 2018
  58. T細胞核移植クローンマウス研究から見えてきた新たな喘息治療の方向性, アレルギーの臨床, 38号, pp. 365-370, 2018
  59. 特集 花粉症の基礎と臨床 アップデート:花粉症における鼻粘膜過敏性亢進の発症機構, アレルギー・免疫, 25号, pp. 156-164, 2018
  60. Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA., Journal of Autoimmunity, 80巻, pp. 28-38, 2017
  61. ★, Hyper-reactive cloned mice generated by direct nuclear transfer of antigen-specific CD4+ T cells., EMBO Reports, 18巻, pp. 885-893, 2017
  62. Identification of biomarker sets for predicting the efficacy of sublingual immunotherapy against pollen-induced allergic rhinitis., International Immunology, 29巻, pp. 291-300, 2017
  63. Th9 cells induce steroid-resistant bronchial hyperresponsiveness in mice., Allergol International, 66巻, pp. S35-40, 2017
  64. Oral administration of ovalbumin after sensitization attenuate symptoms in a mouse model of food allergic enteropathy., Bioscience, Biotechnology, and Biochemistry, 81巻, pp. 1901-1972, 2017
  65. Differential Contribution of Adhesion Molecules to Th1 and Th2 Cell-Mediated Lung and Bowel Inflammation., Biological & Pharmaceutical Bulletin, 40巻, pp. 1081-1805, 2017
  66. 特集 医薬品評価に活用できる新しいアレルギー疾患モデル:抗原特異的CD4陽性T細胞の核移植によるアレルギー性炎症急速発症モデルの樹立, 日本薬理学雑誌, 150号, pp. 83-87, 2017
  67. Essential Contribution of CD4+ T Cells to Antigen-Induced Nasal Hyperresponsiveness in Experimental Allergic Rhinitis., PloS One, 11巻, pp. e0146686, 2016
  68. Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner., PloS One, 11巻, pp. e0150244, 2016
  69. Critical role of CD44 in antigen-induced Th2- but not Th17-mediated murine airway inflammation., Allergology International, 65巻, pp. S59-61, 2016
  70. Th9 cells elicit eosinophil-independent bronchial hyperresponsiveness in mice., Allergology International, 65巻, pp. S24-29, 2016
  71. Crosstalk between histamine and T cells in allergic diseases., Curr Immunol Rev, 2016
  72. Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS)., Journal of Clinical Immunology, 35巻, pp. 661-667, 2015
  73. 特集 疾患バイオマーカー研究の新展開.免疫療法の応答性に関わるバイオマーカー:アンサンブル学習法によるスギ花粉症の治療効果を判定する血清バイオマーカーセットの同定, 日本薬理学雑誌, 146号, pp. 259-262, 2015
  74. 特集 色々なアレルギー疾患における最近の進歩 I.内科.2.Th細胞分化とアレルギー, アレルギー・免疫, 22号, pp. 34-42, 2015
  75. Selective suppression of Th2 cell-mediated lung eosinophilic inflammation by anti-major facilitator super family domain containing 10 monoclonal antibody., Allergology International, 63巻, pp. S29-35, 2014
  76. Antigen-induced mixed and separated inflammation in murine upper and lower airways., Allergology International, 63巻, pp. S59-61, 2014
  77. Food Allergen-induced IgE Response Mouse Model Created by Injection of in vitro Differentiated Th2 Cell Culture and Oral Antigen Intake., Bioscience of Microbiota, Food and Health, 33巻, pp. 41-46, 2014
  78. IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages., Journal of Pharmacological Sciences, 125巻, pp. 394-405, 2014
  79. 集 スギ・ヒノキ花粉症 X.スギ花粉症免疫療法の治療効果に連動したバイオマーカー., アレルギー・免疫, 21号, pp. 94-101, 2014
  80. Transgenic plants for allergen-specific immunotherapy., World J Immunol, 4巻, pp. 141-148, 2014
  81. Oral immunotherapy with transgenic rice seed containing destructed Japanese cedar pollen allergens, Cry j 1 and Cry j 2, against Japanese cedar pollinosis., Plant Biotechnology Journal, 11巻, pp. 66-76, 2013
  82. Identification of Acyl-CoA thioesterase in mouse mesenteric lymph nodes., Biological & Pharmaceutical Bulletin, 36巻, pp. 866-871, 2013
  83. A contraction assay system using primary cultured mouse bronchial smooth muscle cells., International Archives of Allergy and Immunology, 161巻, pp. S93-97, 2013
  84. Existence of antigen-specific IgE is not sufficient for allergic nasal eosinophil infiltration in mice., International Archives of Allergy and Immunology, 161巻, pp. S125-128, 2013
  85. Oral immunotherapy for allergic diseases using transgenic rice seeds: current state and future prospects., International Archives of Allergy and Immunology, 161巻, pp. S164-169, 2013
  86. Selective down-regulation of Th2 cell-mediated airway inflammation in mice by pharmacological intervention of CCR4., Clinical and Experimental Allergy, 42巻, pp. 315-325, 2012
  87. Murine T cell-derived contractile activity for bronchial smooth muscle cells., International Archives of Allergy and Immunology, 158巻, pp. S7-10, 2012
  88. NFAT1 and NFAT2 differentially regulate IL-17A expression in human T cells., International Archives of Allergy and Immunology, 158巻, pp. S30-34, 2012
  89. Inhibition of allergen-induced airway inflammation by low-dose oral immunotherapy with transgenic rice seeds independently of immunoglobulin e synthesis., International Archives of Allergy and Immunology, 158巻, pp. S66-69, 2012
  90. Protein phosphatase 1 is involved in IL-2-induced IL-5 and IL-13 expression in human T cells., Genes to Cells, 17巻, pp. 611-618, 2012
  91. Establishment of monoclonal antibodies against a novel eosinophil-specific cell surface molecule, major facilitator super family domain containing 10., Immunology Letters, 147巻, pp. 80-84, 2012
  92. Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression., Plant Biotechnology Journal, 9巻, pp. 982-990, 2011
  93. Zinc finger protein, multitype 1 suppresses human Th2 development via downregulation of IL-4., International Archives of Allergy and Immunology, 155巻, pp. S53-56, 2011
  94. Comparative analysis of steroid sensitivity of Th cells in vitro and in vivo., International Archives of Allergy and Immunology, 155巻, pp. S110-116, 2011
  95. CD44 is critical for airway accumulation of antigen-specific Th2, but not Th1, cells induced by antigen challenge in mice., European Journal of Immunology, 41巻, pp. 3198-3207, 2011
  96. Vaccination with transgenic rice seed expressing mite allergen: a new option for asthma sufferers?, Expert Review of Vaccines, 10巻, pp. 1249-1251, 2011
  97. 重症喘息におけるステロイド治療抵抗性の機序解明とその治療法の開発, アレルギア, 40号, pp. 96-101, 2011
  98. 東京都医学総合研究所における花粉症等のアレルギー治療に関する研究の取り組み, アレルギーの臨床, 32号, pp. 1147-1150, 2011
  99. 特集 免疫療法 アップデート VIII.免疫療法における効果の予見, アレルギー・免疫, 18号, pp. 64-70, 2011
  100. Selective down-regulation of Th2 cytokines by C-terminal binding protein 2 in human T cells., International Archives of Allergy and Immunology, 152巻, pp. S18-21, 2010
  101. Effect of sublingual immunotherapy on antigen-induced bronchial and nasal inflammation in mice., International Archives of Allergy and Immunology, 152巻, pp. S75-78, 2010
  102. Eosinophils are required for the induction of bronchial hyperresponsiveness in a Th-transfer model of Balb/c background., International Archives of Allergy and Immunology, 152巻, pp. S79-82, 2010
  103. Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition., The Journal of Investigative Dermatology, 130巻, pp. 2760-2767, 2010
  104. アレルギー疾患に対するオーダーメード医療 X.免疫療法:スギ花粉症舌下免疫療法の治療効果に関わるバイオマーカーの検索, アレルギー・免疫, 17号, pp. 96-103, 2010
  105. T細胞の遊走とCD44, 臨床免疫・アレルギー科, 53号, pp. 551-555, 2010
  106. Suppressive role of C-terminal binding protein 1 in IL-4 synthesis in human T cells., Biochemical and Biophysical Research Communications, 382巻, pp. 326-330, 2009
  107. T-box 21 transcription factor is responsible for distorted TH2 differentiation in human peripheral CD4+ T cells., The Journal of Allergy and Clinical Immunology, 123巻, pp. 813-823, 2009
  108. Regulation of DNA demethylation during maturation of CD4+ naive T cells by the conserved noncoding sequence 1., Journal of Immunology, 182巻, pp. 7698-7707, 2009
  109. Murine Th clones confer late asthmatic response upon antigen challenge., International Archives of Allergy and Immunology, 149巻, pp. S2-6, 2009
  110. Development of transgenic rice expressing mite antigen for a new concept of immunotherapy., International Archives of Allergy and Immunology, 149巻, pp. S21-24, 2009
  111. Proteomic Approach to FcepsilonRI aggregation-initiated signal transduction cascade in human mast cells., International Archives of Allergy and Immunology, 149巻, pp. S73-76, 2009
  112. Evaluation of cysteinyl leukotriene-induced contraction of human cultured bronchial smooth muscle cells., International Archives of Allergy and Immunology, 149巻, pp. S83-86, 2009
  113. NFATサブタイプ阻害薬開発の意義と可能性, 薬学研究の進歩, 25号, pp. 7-10, 2009
  114. Differential contribution of NFATc2 and NFATc1 to TNF-alpha gene expression in T cells., Journal of Immunology, 180巻, pp. 319-326, 2008
  115. Selective inhibitors of nuclear factor of activated T cells: potential therapeutic drugs for the treatment of immunological and inflammatory diseases., Inflammation & Allergy Drug Targets, 7巻, pp. 35-40, 2008
  116. Airway eosinophilic inflammation is attenuated in conserved noncoding sequence-1 deficient mice., International Archives of Allergy and Immunology, 146巻, pp. S2-6, 2008
  117. Downregulation of IL-13 gene transcription by T-bet in human T cells., International Archives of Allergy and Immunology, 146巻, pp. S33-35, 2008
  118. A contraction assay system using established human bronchial smooth muscle cells., International Archives of Allergy and Immunology, 146巻, pp. S36-39, 2008
  119. IL-4 gene transcription in human T cells is suppressed by T-bet., International Archives of Allergy and Immunology, 143巻, pp. S68-70, 2007
  120. IL-9 production by peripheral blood mononuclear cells of atopic asthmatics., International Archives of Allergy and Immunology, 143巻, pp. S76-79, 2007
  121. Effect of formoterol on allergen-induced cytokine synthesis by atopic asthmatics., International Archives of Allergy and Immunology, 143巻, pp. S106-109, 2007
  122. Selective suppression of Th2 cell-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists., International Immunology, 19巻, pp. 913-921, 2007
  123. Functional chemokine receptors in allergic diseases: is CCR8 a novel therapeutic target?, Mini Reviews in Medicinal Chemistry, 6巻, pp. 463-466, 2006
  124. Characterization of binding activity between nuclear factor of activated T cells and calcineurin by amplified luminescent proximity homogeneous assay., Journal of Immunological Methods, 312巻, pp. 105-110, 2006
  125. IL-2-induced IL-13 production by allergen-specific human helper T cell clones., International Archives of Allergy and Immunology, 140巻, pp. S51-54, 2006
  126. Th2 cell-mediated chemokine synthesis is involved in allergic airway inflammation in mice., International Archives of Allergy and Immunology, 140巻, pp. S55-58, 2006
  127. Genetic factors in the treatment of bronchial asthma., Expert Review of Clinical Immunology, 2巻, pp. 727-735, 2006
  128. Role of GATA-3 in IL-5 gene transcription by CD4+ T cells of asthmatic patients., International Archives of Allergy and Immunology, 137巻, pp. S55-59, 2005
  129. Correlation between mRNA expression in Th1/Th2 cytokines and their specific transcription factors in human helper T cell clones., Immunology and Cell Biology, 83巻, pp. 536-541, 2005
  130. NFAT-カルシニューリン阻害剤, 日本臨床, 63号, pp. 1633-1639, 2005
  131. GATA-3 suppresses IFN-gamma promoter activity independently of binding to cis-regulatory elements., FEBS Letters, 570巻, pp. 63-68, 2004
  132. Interaction with monocytes enhances IL-5 gene transcription in peripheral T cells of asthmatic patients., International Archives of Allergy and Immunology, 131巻, pp. S20-25, 2003
  133. Vav-induced activation of the human IFN-gamma gene promoter is mediated by upregulation of AP-1 activity., FEBS Letters, 514巻, pp. 153-158, 2002
  134. Transient contribution of mast cells to pulmonary eosinophilia but not to hyperresponsiveness., Clinical and Experimental Allergy, 32巻, pp. 475-483, 2002
  135. Potential initiation of eosinophilic skin inflammation by antigen-specific T helper type 2 cells., International Archives of Allergy and Immunology, 128巻, pp. S21-23, 2002
  136. Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors., Clinical and Experimental Immunology, 128巻, pp. 460-466, 2002
  137. Transcriptional regulation of the IL-5 gene in peripheral T cells of asthmatic patients., Clinical and Experimental Immunology, 130巻, pp. 475-483, 2002
  138. 抗原特異的Th2細胞によるアトピー性皮膚炎モデルの可能性, アレルギー科, 13号, pp. 39-42, 2002
  139. Correlation between eosinophilia induced by CD4+ T cells and bronchial hyperesponseiveness., International Immunology, 13巻, pp. 329-339, 2001
  140. Vav/Rac1-mediated activation of the JNK/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the IL-2 gene promoter., Molecular and Cellular Biology, 21巻, pp. 3126-3136, 2001
  141. Humoral immunity is dispensable for the local recruitment of antigen-specific Th2 cells., International Archives of Allergy and Immunology, 125巻, pp. S17-18, 2001
  142. Dynamics of antigen-specific helper T cells at the initiation of airway eosinophilic inflammation., European Journal of Immunology, 31巻, pp. 2669-2679, 2001
  143. 好酸球の浸潤とTh細胞, 臨床免疫, 35号, pp. 155-160, 2001
  144. IL-5 synthesis by T cells of allergic subjects is regulated at the transcriptional level., International Archives of Allergy and Immunology, 122巻, pp. S63-66, 2000
  145. Control of interleukin-5 production by human helper T cells as a treatment for eosinophilic inflammation: Comparison of in vitro and in vivo effects between selective and nonselective cytokine synthesis inhibitors., The Journal of Allergy and Clinical Immunology, 106巻, pp. S58-64, 2000
  146. Transcriptional regulation of IL-5 gene by nontransformed human T cells through the proximal promoter element., Internal Medicine, 39巻, pp. 618-625, 2000
  147. Cloned Th cells confer eosinophilic inflammation and bronchial hyperresponsiveness., International Archives of Allergy and Immunology, 118巻, pp. 136-139, 1999
  148. Regulatory mechanisms of human T cell IL-5 synthesis: differential roles of the proximal promoter-binding proteins in IL-5 gene transcription., International Archives of Allergy and Immunology, 118巻, pp. 271-274, 1999
  149. Transcriptional control of IL-5 gene by human helper T cells: IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis., The Journal of Allergy and Clinical Immunology, 103巻, pp. S429-436, 1999
  150. Cyclic AMP suppresses interleukin-5 synthesis by human helper T cells via the downregulation of the calcium mobilization pathway., British Journal of Pharmacology, 127巻, pp. 521-529, 1999
  151. p38 MAP kinase regulates human T cell IL-5 synthesis., Journal of Immunology, 163巻, pp. 4763-4771, 1999
  152. Primary role of CD4+ T cells and supplemental role of mast cells in allergic pulmonary eosinophilia., International Archives of Allergy and Immunology, 120巻, pp. S15-18, 1999
  153. アレルギーとT細胞—アトピー性疾患はなぜ起こる, Immunol Front, 9号, pp. 59-62, 1999
  154. A selective type 4 phosphodiesterase inhibitor, T-440, modulates intracellular cAMP level and interleukin-2 production of Jurkat cells., Immunopharmacology, 38巻, pp. 247-252, 1998
  155. A novel anti-allergic drug, betotastine besilate, suppresses interleukin-5 production by human peripheral blood mononuclear cells., Biological & Pharmaceutical Bulletin, 21巻, pp. 411-413, 1998
  156. Evidence that cyclosporin A and dexamethasone inhibit allergic airway eosinophilic inflammation via suppression of interleukin-5 synthesis by T cells., British Journal of Pharmacology, 124巻, pp. 1425-1432, 1998
  157. IL-5-producing T cells that induce airway eosinophilia and hyperresponsiveness are suppressed by dexamethasone and cyclosporin A in mice., International Archives of Allergy and Immunology, 117巻, pp. S24-27, 1998
  158. Prevention of ozone-induced airway hyperresponsiveness and epithelial injury by phosphodiesterase inhibitors in guinea pigs., Environmental Toxicology and Pharmacology, 3巻, pp. 201-209, 1997
  159. IL-2-induced IL-5 synthesis, but not proliferation, of human CD4+ T cells is suppressed by FK506., Journal of Immunology, 158巻, pp. 3659-3665, 1997
  160. Effect of T-440, a novel type IV phosphodiesterase inhibitor, on allergen-induced immediate and late asthmatic reaction and leukocyte infiltration into the airways of guinea pigs., International Archives of Allergy and Immunology, 112巻, pp. 406-411, 1997
  161. Two distinct pathways of IL-5 synthesis in allergen-specific human T cell clones are suppressed by glucocorticoids., Blood, 89巻, pp. 2891-2900, 1997
  162. Successful transfer of late phase eosinophil infiltration in the lung by infusion of helper T cell clones., American Journal of Respiratory Cell and Molecular Biology, 16巻, pp. 448-454, 1997
  163. Dissection of human IL-5 promoter--essential role of CLEO element in human IL-5 gene transcription., International Archives of Allergy and Immunology, 113巻, pp. 272-274, 1997
  164. Selective suppression of IL-5 synthesis by OM-01--pinpoint treatment of atopic diseases by IL-5 gene transcription inhibitor., International Archives of Allergy and Immunology, 113巻, pp. 331-334, 1997
  165. Two differential effects of cyclic AMP on IL-5 production by antigen-specific human T cell line., The Journal of Pharmacology and Experimental Therapeutics, 283巻, pp. 345-349, 1997
  166. Development of lung eosinophilic inflammation by the infusion of IL-5-producing T cell clones., International Archives of Allergy and Immunology, 114巻, pp. S10-13, 1997
  167. Control of allergic diseases by regulation of cytokine gene transcription., Arbeiten aus dem Paul-Ehrlich-Institut zu Frankfurt A.M, 91巻, pp. 209-221, 1997
  168. Angiotensin-converting enzyme inhibitors can potentiate ozone-induced airway hyperresponsiveness., European Journal of Pharmacology, 337巻, pp. 259-265, 1997
  169. Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: A study with allergen—specific human helper T cells., The Journal of Allergy and Clinical Immunology, 100巻, pp. S56-64, 1997
  170. Bronchial anti-spasmogenic effects and its selectivity of T-440, phosphodiesterase type 4 inhibitor, in the dog., Biological & Pharmaceutical Bulletin, 20巻, pp. 1261-1265, 1997
  171. IL-5遺伝子転写制御によるアレルギー治療, 日本胸部疾患学会雑誌, 35号, pp. 47-51, 1997
  172. 臨床アレルギーの入門講座、IL-5産生機構, アレルギーの臨床, 17号, pp. 1109-1117, 1997
  173. リウマチ性疾患と好酸球、IL-5産生性T細胞による好酸球性炎症, リウマチ科, 18号, pp. 329-335, 1997
  174. Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans., Journal of Medicinal Chemistry, 39巻, pp. 2696-2704, 1996
  175. IL-15 promotes cytokine production of human T helper cells., Journal of Immunology, 156巻, pp. 2400-2405, 1996
  176. Interleukin-5 production by peripheral blood mononuclear cells of asthmatic patients is suppressed by T-440: relation to phosphodiesterase inhibition., The Journal of Pharmacology and Experimental Therapeutics, 279巻, pp. 240-246, 1996
  177. Inhibitory effect of a novel phosphodiesterase IV inhibitor, T-440 on antigen- and chemical mediator-induced bronchoconstrictions in guinea pigs in vivo., Japanese Journal of Pharmacology, 72巻, pp. 1-8, 1996
  178. A novel phosphodiesterase inhibitor, T-440; possible management of eosinophilic inflammation by down-regulation of Interleukin-5 production., International Archives of Allergy and Immunology, 111巻, pp. S16-18, 1996
  179. A critical role of IL-2 for the production and gene transcription of IL-5 in allergen-specific human T cell clones., International Immunology, 8巻, pp. 1889-1895, 1996
  180. IL-5産生制御によるアトピー性疾患の治療, 日本臨床免疫学会会誌, 19号, pp. 598-601, 1996
  181. IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A., International Immunology, 7巻, pp. 449-457, 1995
  182. Allergen-specific human T cell clones produce interleukin-5 upon stimulation with the Th1 cytokine interleukin-2., International Archives of Allergy and Immunology, 107巻, pp. 220-222, 1995
  183. Analysis of human interleukin-5 gene transcription by T cell clones and hybridomas., International Archives of Allergy and Immunology, 107巻, 1-3号, 1995
  184. Importance of impairment of the airway epithelium for ozone-induced airway hyperresponsiveness in guinea pigs., Japanese Journal of Pharmacology, 67巻, pp. 375-382, 1995
  185. Difference among angiotensin-converting enzyme inhibitors in potentiating effects on bradykinin-induced microvascular leakage in guinea pig airways., Japanese Journal of Pharmacology, 69巻, pp. 111-118, 1995
  186. Regulation of interleukin-5 production by peripheral blood mononuclear cells from atopic patients with FK506, cyclosporin A and glucocorticoid., International Archives of Allergy and Immunology, 104巻, pp. S32-35, 1994
  187. Reflex activities of the upper airway muscles during experimental nasal occlusion in anesthetized dogs., The Journal of Veterinary Medical Science, 53巻, pp. 93-99, 1991

著書等出版物

  1. 2004年, Immunology 2004, Comparative analysis for calcineurin binding activity of NFAT family members., Medimond International Proceedings, 2004年
  2. 1998年, 気道アレルギー ’98, アトピー型喘息と非アトピー型喘息の境界., メディカルビュー社, 1998年
  3. 1996年, アレルギー疾患Q&A, シグナル伝達について教えてください, 医薬ジャーナル社, 1996年
  4. 1996年, New Horizons in Allergy and Immunotherapy, Enhanced production and gene expression of IL-5 in bronchial asthma: Possible management of atopic diseases with IL-5 specific gene transcription inhibitor., Plenum Publishing Corporation, 1996年

招待講演、口頭・ポスター発表等

  1. T細胞による味覚センシングとアレルギー, 神沼 修, 日本食品免疫学会第18回学術大会, 2022年11月09日, 招待
  2. Calcineurin/NFATシグナルのダイバーシティを生む分子メカニズム, 神沼 修, 北村 紀子、宮武 昌一郎、森 晶夫、廣井 隆親, 第93回日本生化学会大会, 2020年09月14日, 招待
  3. 統合比較解析で見えてきた舌下免疫療法の作用メカニズム.神沼 修、後藤 穣、大久保 公裕、中谷 明弘、廣井 隆親.第92回日本薬理学会年会(大阪)シンポジウム「アレルゲン免疫療法の薬理学」, 2019年03月16日, 招待
  4. アレルギー性鼻炎のメカニズムと抗原特異的免疫療法に対する実験動物学的解析.神沼 修.第37回日本耳鼻咽喉科免疫アレルギー大会(大阪)Basic & Clinical Conference「アレルギー性鼻炎に対する抗原特異的免疫療法」, 2019年02月09日, 招待
  5. Functional diversity of NFAT family transcription factors. Kaminuma O, Kitamura N, Miyatake S, Mori A, Hiroi T. 第91回日本生化学会大会(京都)シンポジウム「New investigation for immune cell signaling」, 2018年09月25日, 招待
  6. T細胞の核移植によるアレルギー疾患モデルマウス. 神沼 修. 第55回筑波実験動物研究会講演会(つくば), 2018年06月15日, 招待
  7. Adaptive Boostingアルゴリズムによる免疫療法に対する有効性診断法の開発. 神沼 修. 2017年度生命科学系学会合同年次大会(神戸)ワークショップ「疾患バイオマーカー研究の新潮流」, 2017年12月09日, 招待
  8. 免疫療法の基礎.神沼 修.第3回総合アレルギー講習会「免疫療法」(横浜), 2016年12月17日, 招待
  9. Rapid development of house dust mite-induced allergic inflammation. Kaminuma O. 第89回日本薬理学会年会(横浜)シンポジウム「医薬品評価に活用できる新しいアレルギー疾患モデル」, 2016年03月09日, 招待
  10. 免疫療法の治療効果を予見するバイオマーカーセット.神沼 修. 第88回日本薬理学会年会(名古屋)ワークショップ「疾患バイオマーカー研究の新展開」, 2015年03月20日, 招待
  11. 新しい花粉症モデル:マウスにおけるT細胞依存性鼻粘膜過敏性亢進反応.神沼 修、西村 友枝、佐伯 真弓、松岡 邦枝、米川 博通、後藤 穣、大久保 公裕、森 晶夫、廣井 隆親. 第63回日本アレルギー学会秋季学術大会(東京)イブニングシンポジウム「東京都花粉症プロジェクト」, 2013年11月28日, 招待
  12. 形質転換イネを用いたアレルギー対策.神沼 修.第59回日本アレルギー学会秋季学術集会(秋田)シンポジウム「アレルギー疾患の治療最前線と将来展望」, 2009年10月29日, 招待
  13. NFATサブタイプにおける機能的相違の分子メカニズム -次世代型プロトピックは誕生するか-.神沼 修.第30回皮膚科免疫セミナー(東京), 2006年03月04日, 招待
  14. IL-5産生性T細胞による好酸球性炎症の発症. 神沼 修、森 晶夫、須甲 松伸、吉川 日出雄、内藤 一秋、奥平 博一、伊藤 幸治. 第46回日本アレルギー学会総会(宇都宮)シンポジウム「好酸球:その2:産生と浸潤」, 1996年10月30日, 招待

受賞

  1. 2018年07月10日, 優秀教員奨励制度 研究特別奨励賞, 山梨大学
  2. 2013年11月28日, 真鍋奨学賞, 日本アレルギー協会

外部資金

競争的資金等の採択状況

  1. 基盤研究A 2022~2025年度「核移植クローン技術に基づく免疫応答・疾患発症機構の包括的研究基盤」
  2. 基盤研究B 2019~2021年度「免疫研究バイオリソースとしてのT細胞クローンマウスの有用性」
  3. 放射線災害・医科学研究拠点  2020~2022年度トライアングルプロジェクト「組織幹細胞動態を基軸としたモデル動物における線量率効果の研究」
  4. 放射線災害・医科学研究拠点  2019~2022年度トライアングルプロジェクト「放射線誘発MDSの発症機序の解明」
  5. 挑戦的研究(萌芽)  2018〜2020年度「アレルギー疾患におけるT細胞サブセットに共通する過敏性亢進発症機構の解明」
  6. 基盤研究C  2015〜2017年度「抗原特異的モノクローナルT細胞レセプターを介する免疫機構の解明」
  7. 2013〜2014年度 第1回研究成果最適展開支援プログラム(A-STEP)探索タイプ「ヒト好酸球特異的抗体の樹立にもとづく好酸球増多性疾患治療法の開発」
  8. 基盤研究C  2012〜2014年度「誘導型および恒常型好中球欠損マウスの樹立にもとづくアレルギー性炎症の解析」
  9. 基盤研究C(一般) 2009〜2011年度「NFATファミリーの機能的相違にもとづく特異的制御法の開発」

社会活動

委員会等委員歴

  1. 山梨大学総合分析実験センター 客員教授, 2019年04月
  2. 東京都医学総合研究所 客員研究員, 2016年04月
  3. 国立研究開発法人理化学研究所バイオリソースセンター 客員研究員, 2016年04月
  4. 国立病院機構相模原病院 客員研究員, 2018年04月
  5. Experimental Animals 編集委員, 2018年04月, 2023年03月
  6. Translational and Regulatory Sciences 編集委員, 2019年08月, 2023年03月
  7. Internatinal Journal of Moleculer Sciences 編集委員, 2020年10月, 2023年03月
  8. 山梨大学 大学院医工農学総合教育部大学院担当 非常勤講師, 2019年04月, 2020年03月