OSAMU KAMINUMA
Last Updated :2023/05/10
- Affiliations, Positions
- Research Institute for Radiation Biology and Medicine, Professor
- E-mail
- okami
hiroshima-u.ac.jp
- Self-introduction
- Development of mouse models useful to create novel treatments for various diseases
Basic Information
Academic Degrees
Educational Activity
- [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine
Research Fields
- Agricultural sciences;Animal life science;Veterinary medical science
- Medicine,dentistry, and pharmacy;Basic medicine;Immunology
- Agricultural sciences;Boundary agriculture;Applied molecular and cellular biology
- Medicine,dentistry, and pharmacy;Pharmacy;Biological pharmacy
Research Keywords
- Experimental Animals, Immunology, Genetic modification, Somatic cell clone, Artificial chromosome, T cell, Allergy
Affiliated Academic Societies
- Japanese Association for Laboratory Animal Science
- Japanese Society for Immunology
- Japanese Society of Allergology
- The Japanese Biochemical Society
- The Japanese Pharmacological Society
- The Workshop on Eosinophils in Allergy and Related Diseases
- The Japanese Society of Veterinary Science
- Japanese Association for Laboratory Animal Medicine
- Japan Allergy Foundation
- The American Association of Immunologists
- The American Society for Biochemistry and Molecular Biology
Educational Activity
Course in Charge
- 2023, Liberal Arts Education Program1, 1Term, Foundation biology for life science
- 2023, Undergraduate Education, Intensive, Practice for medical research
- 2023, Undergraduate Education, 2Term, Outline of Immunology
- 2023, Graduate Education (Master's Program) , First Semester, Seminar
- 2023, Graduate Education (Master's Program) , Second Semester, Seminar
- 2023, Graduate Education (Master's Program) , First Semester, Research
- 2023, Graduate Education (Master's Program) , Second Semester, Research
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Disease Model
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Disease Model
- 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Disease Model
- 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Disease Model
- 2023, Graduate Education (Doctoral Program) , Second Semester, Introduction to Radiation Biology
Research Activities
Academic Papers
- Generation of reporter mice for detecting the transcriptional activity of nuclear factor of activated T cells, Exprerimental Animals, 202304
- Evolutionary mechanisms underlying the diversification of nuclear factor of activated T cells across vertebrates, Scientific Reports, 13, 6468, 202305
- Suppressive Effect of Lactococcus lactis subsp. cremoris YRC3780 on a Murine Model of Japanese Cedar Pollinosis., Pathogens, 11, 1347, 202211
- Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness, Journal of Pharmacological Sciences, 150(4), 275-278, 202210
- BACH1 promotes clear cell renal cell carcinoma progression via upregulating oxidative stress-related tumorigenicity., Cancer Science, 114, 436-448, 202209
- DDX41 expression is associated with tumor necrosis in clear cell renal cell carcinoma and in cooperation with VHL loss leads to worse prognosis., Urologic Oncology, 40(10), 456.e9-456.e18, 202207
- Th17-Dependent Nasal Hyperresponsiveness Is Mitigated by Steroid Treatment, BIOMOLECULES, 12(5), 202205
- Regulation of Th2 responses by Lactococcus lactis subsp. cremoris YRC3780 alleviates DNCB-induced atopic dermatitis in the mouse model, JOURNAL OF FUNCTIONAL FOODS, 94, 202207
- Therapeutic Potential for Intractable Asthma by Targeting L-Type Amino Acid Transporter 1, BIOMOLECULES, 12(4), 202204
- Expression and function of nicotinic acetylcholine receptors in induced regulatory T cells, International Journal of Molecular Sciences, 23, 1779, 2022
- Suppressive effect of dexamethasone on murine Th9 cell-mediated nasal eosinophlic inflammation, ASIA PACIFIC ALLERGY, 11(3), 202107
- L-type amino acid transporter 1 inhibitor suppresses murine Th2 cell-mediated bronchial hyperresponsiveness independently of eosinophil accumulation, ASIA PACIFIC ALLERGY, 11(3), 202107
- Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(5), 202103
- Sublingual Immunotherapy: How Sublingual Allergen Administration Heals Allergic Diseases; Current Perspective about the Mode of Action, PATHOGENS, 10(2), 202102
- Progress of genome editing technology and developmental biology useful for radiation research, Journal of Radiation Research, 62, i53-i63, 2021
- Sublingual immunotherapy: how sublingual allergen administration heals allergic diseases; current perspective about the mode of action, Pathogens, 10(2), 147, 2021
- Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development, International Journal of Molecular Science, 22, 2725, 2021
- Suppressive effect of dexamethasone on murine Th9 cell-mediated nasal eosinophilic inflammation, Asia Pacific Allergy, 11, e25, 2021
- L-type amino acid transporter 1 inhibitor suppresses murine Th2 cell-mediated bronchial hyperresponsiveness independently of eosinophil accumulation, Asia Pacific Allergy, 11, e33, 202107
- Role of CD4(+) T Cells in Allergic Airway Diseases: Learning from Murine Models, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(20), 202010
- Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression, JOURNAL OF MEDICAL INVESTIGATION, 67(3-4), 289-297, 202008
- Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction, CLINICAL CANCER RESEARCH, 26(8), 2065-2079, 202004
- Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation, ASIA PACIFIC ALLERGY, 10(2), 202004
- Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production, INTERNATIONAL IMMUNOLOGY, 32(3), 187-201, 202003
- LAT1-specific inhibitor is effective against T cell-mediated allergic skin inflammation, ALLERGY, 75(2), 463-467, 202002
- Association of Basophil-Expressing Genes with Effectiveness of Sublingual Immunotheraphy, JOURNAL OF NIPPON MEDICAL SCHOOL, 87(1), 49-52, 202002
- Identification of novel interacting regions involving calcineurin and nuclear factor of activated T cells, FASEB JOURNAL, 34(2), 3197-3208, 202002
- T Cell-Mediated Nasal Hyperresponsiveness in Allergic Rhinitis, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 43(1), 36-40, 202001
- LAT1-specific inhibitor is effective against T cell-mediated allergic skin inflammation., Allergy, 75, 463-467, 2020
- Basophil-expressing genes related with the efficacy of sublingual immunotherapy., Journal of Nippon Medical School, 87(49-52), 2020
- T cell-mediated nasal hyperresponsiveness in allergic rhinitis., Biological and Pharmaceutical Bulletin, 43, 36-40, 2020
- Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production., International Immunology, 32, 187-201, 2020
- L-type amino acid transporter 1 (LAT1)-specific inhibitor is effective against T cell-mediated nasal hyperresponsiveness., Allergology International, 69(3), 455-458, 2020
- Identification of novel interacting regions involving calcineurin and nuclear factor of activated T cells., FASEB Journal, 34, 3197-3208, 2020
- Kdm6a deficiency activates inflammatory pathways, promotes M2 macrophage polarization and causes bladder cancer in cooperation with p53 dysfunction., Clinical Cancer Research, 26(8), 2065-2079, 2020
- Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation, Asia Pacific Allergy, 10(2), e18, 2020
- Epicutaneous allergen administration without antigen delivery device induces local T cell response and alleviates food allergic enteropathy., Allergology International, 69, 622-625, 2020
- Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression, Journal of Medical Investigation, 67(3-4), 289-297, 2020
- Role of CD4+ T Cells in Allergic Airway Diseases: Learning from Murine Models, International Journal of Molecular Science, 21(20), 7480, 2020
- Thrombospondin 1-mediated suppression of mast cell degranulation is involved in the efficacy of sublingual immunotherapy., Allergology International, 68, S9-10, 2019
- Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness., International Journal of Molecular Sciences, 20, 2980, 2019
- T-Helper Type 2 Cells Direct Antigen-Induced Eosinophilic Skin Inflammation in Mice., Allergy, asthma & immunology Research, 10, 77-82, 2018
- Down-regulation of NFAT3 due to lack of T-box transcription factor TBX5 is crucial for cytokine expression in T cells., Journal of Immunology, 200, 92-100, 2018
- Contribution of neuraminidase 3 to the differentiation of induced regulatory T cells., Genes to Cells, 23, 112-116, 2018
- Involvement of taste receptors in the effectiveness of sublingual immunotherapy., Allergology International, 67, 421-424, 2018
- Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis., Allergology International, 67, S25-31, 2018
- Microarray-Based Multivariate Analysis of the Effectiveness of Sublingual Immunotherapy for Cedar Pollinosis., Allergy, Asthma & Immunology Research, 10, 562-569, 2018
- Serum Cytokine Interactions Are Implicated in the Mechanism of Action of Sublingual Immunotherapy for Japanese Cedar Pollinosis., Journal of Nippon Medical School, 85, 250-258, 2018
- Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA., Journal of Autoimmunity, 80, 28-38, 2017
- ★, Hyper-reactive cloned mice generated by direct nuclear transfer of antigen-specific CD4+ T cells., EMBO Reports, 18, 885-893, 2017
- Identification of biomarker sets for predicting the efficacy of sublingual immunotherapy against pollen-induced allergic rhinitis., International Immunology, 29, 291-300, 2017
- Th9 cells induce steroid-resistant bronchial hyperresponsiveness in mice., Allergol International, 66, S35-40, 2017
- Oral administration of ovalbumin after sensitization attenuate symptoms in a mouse model of food allergic enteropathy., Bioscience, Biotechnology, and Biochemistry, 81, 1901-1972, 2017
- Differential Contribution of Adhesion Molecules to Th1 and Th2 Cell-Mediated Lung and Bowel Inflammation., Biological & Pharmaceutical Bulletin, 40, 1081-1805, 2017
- Essential Contribution of CD4+ T Cells to Antigen-Induced Nasal Hyperresponsiveness in Experimental Allergic Rhinitis., PloS One, 11, e0146686, 2016
- Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner., PloS One, 11, e0150244, 2016
- Critical role of CD44 in antigen-induced Th2- but not Th17-mediated murine airway inflammation., Allergology International, 65, S59-61, 2016
- Th9 cells elicit eosinophil-independent bronchial hyperresponsiveness in mice., Allergology International, 65, S24-29, 2016
- Crosstalk between histamine and T cells in allergic diseases., Curr Immunol Rev, 2016
- Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS)., Journal of Clinical Immunology, 35, 661-667, 2015
- Selective suppression of Th2 cell-mediated lung eosinophilic inflammation by anti-major facilitator super family domain containing 10 monoclonal antibody., Allergology International, 63, S29-35, 2014
- Antigen-induced mixed and separated inflammation in murine upper and lower airways., Allergology International, 63, S59-61, 2014
- Food Allergen-induced IgE Response Mouse Model Created by Injection of in vitro Differentiated Th2 Cell Culture and Oral Antigen Intake., Bioscience of Microbiota, Food and Health, 33, 41-46, 2014
- IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages., Journal of Pharmacological Sciences, 125, 394-405, 2014
- Transgenic plants for allergen-specific immunotherapy., World J Immunol, 4, 141-148, 2014
- Oral immunotherapy with transgenic rice seed containing destructed Japanese cedar pollen allergens, Cry j 1 and Cry j 2, against Japanese cedar pollinosis., Plant Biotechnology Journal, 11, 66-76, 2013
- Identification of Acyl-CoA thioesterase in mouse mesenteric lymph nodes., Biological & Pharmaceutical Bulletin, 36, 866-871, 2013
- A contraction assay system using primary cultured mouse bronchial smooth muscle cells., International Archives of Allergy and Immunology, 161, S93-97, 2013
- Existence of antigen-specific IgE is not sufficient for allergic nasal eosinophil infiltration in mice., International Archives of Allergy and Immunology, 161, S125-128, 2013
- Oral immunotherapy for allergic diseases using transgenic rice seeds: current state and future prospects., International Archives of Allergy and Immunology, 161, S164-169, 2013
- Selective down-regulation of Th2 cell-mediated airway inflammation in mice by pharmacological intervention of CCR4., Clinical and Experimental Allergy, 42, 315-325, 2012
- Murine T cell-derived contractile activity for bronchial smooth muscle cells., International Archives of Allergy and Immunology, 158, S7-10, 2012
- NFAT1 and NFAT2 differentially regulate IL-17A expression in human T cells., International Archives of Allergy and Immunology, 158, S30-34, 2012
- Inhibition of allergen-induced airway inflammation by low-dose oral immunotherapy with transgenic rice seeds independently of immunoglobulin e synthesis., International Archives of Allergy and Immunology, 158, S66-69, 2012
- Protein phosphatase 1 is involved in IL-2-induced IL-5 and IL-13 expression in human T cells., Genes to Cells, 17, 611-618, 2012
- Establishment of monoclonal antibodies against a novel eosinophil-specific cell surface molecule, major facilitator super family domain containing 10., Immunology Letters, 147, 80-84, 2012
- Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression., Plant Biotechnology Journal, 9, 982-990, 2011
- Zinc finger protein, multitype 1 suppresses human Th2 development via downregulation of IL-4., International Archives of Allergy and Immunology, 155, S53-56, 2011
- Comparative analysis of steroid sensitivity of Th cells in vitro and in vivo., International Archives of Allergy and Immunology, 155, S110-116, 2011
- CD44 is critical for airway accumulation of antigen-specific Th2, but not Th1, cells induced by antigen challenge in mice., European Journal of Immunology, 41, 3198-3207, 2011
- Vaccination with transgenic rice seed expressing mite allergen: a new option for asthma sufferers?, Expert Review of Vaccines, 10, 1249-1251, 2011
- Selective down-regulation of Th2 cytokines by C-terminal binding protein 2 in human T cells., International Archives of Allergy and Immunology, 152, S18-21, 2010
- Effect of sublingual immunotherapy on antigen-induced bronchial and nasal inflammation in mice., International Archives of Allergy and Immunology, 152, S75-78, 2010
- Eosinophils are required for the induction of bronchial hyperresponsiveness in a Th-transfer model of Balb/c background., International Archives of Allergy and Immunology, 152, S79-82, 2010
- Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition., The Journal of Investigative Dermatology, 130, 2760-2767, 2010
- Suppressive role of C-terminal binding protein 1 in IL-4 synthesis in human T cells., Biochemical and Biophysical Research Communications, 382, 326-330, 2009
- T-box 21 transcription factor is responsible for distorted TH2 differentiation in human peripheral CD4+ T cells., The Journal of Allergy and Clinical Immunology, 123, 813-823, 2009
- Regulation of DNA demethylation during maturation of CD4+ naive T cells by the conserved noncoding sequence 1., Journal of Immunology, 182, 7698-7707, 2009
- Murine Th clones confer late asthmatic response upon antigen challenge., International Archives of Allergy and Immunology, 149, S2-6, 2009
- Development of transgenic rice expressing mite antigen for a new concept of immunotherapy., International Archives of Allergy and Immunology, 149, S21-24, 2009
- Proteomic Approach to FcepsilonRI aggregation-initiated signal transduction cascade in human mast cells., International Archives of Allergy and Immunology, 149, S73-76, 2009
- Evaluation of cysteinyl leukotriene-induced contraction of human cultured bronchial smooth muscle cells., International Archives of Allergy and Immunology, 149, S83-86, 2009
- Differential contribution of NFATc2 and NFATc1 to TNF-alpha gene expression in T cells., Journal of Immunology, 180, 319-326, 2008
- Selective inhibitors of nuclear factor of activated T cells: potential therapeutic drugs for the treatment of immunological and inflammatory diseases., Inflammation & Allergy Drug Targets, 7, 35-40, 2008
- Airway eosinophilic inflammation is attenuated in conserved noncoding sequence-1 deficient mice., International Archives of Allergy and Immunology, 146, S2-6, 2008
- Downregulation of IL-13 gene transcription by T-bet in human T cells., International Archives of Allergy and Immunology, 146, S33-35, 2008
- A contraction assay system using established human bronchial smooth muscle cells., International Archives of Allergy and Immunology, 146, S36-39, 2008
- IL-4 gene transcription in human T cells is suppressed by T-bet., International Archives of Allergy and Immunology, 143, S68-70, 2007
- IL-9 production by peripheral blood mononuclear cells of atopic asthmatics., International Archives of Allergy and Immunology, 143, S76-79, 2007
- Effect of formoterol on allergen-induced cytokine synthesis by atopic asthmatics., International Archives of Allergy and Immunology, 143, S106-109, 2007
- Selective suppression of Th2 cell-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists., International Immunology, 19, 913-921, 2007
- Functional chemokine receptors in allergic diseases: is CCR8 a novel therapeutic target?, Mini Reviews in Medicinal Chemistry, 6, 463-466, 2006
- Characterization of binding activity between nuclear factor of activated T cells and calcineurin by amplified luminescent proximity homogeneous assay., Journal of Immunological Methods, 312, 105-110, 2006
- IL-2-induced IL-13 production by allergen-specific human helper T cell clones., International Archives of Allergy and Immunology, 140, S51-54, 2006
- Th2 cell-mediated chemokine synthesis is involved in allergic airway inflammation in mice., International Archives of Allergy and Immunology, 140, S55-58, 2006
- Genetic factors in the treatment of bronchial asthma., Expert Review of Clinical Immunology, 2, 727-735, 2006
- Role of GATA-3 in IL-5 gene transcription by CD4+ T cells of asthmatic patients., International Archives of Allergy and Immunology, 137, S55-59, 2005
- Correlation between mRNA expression in Th1/Th2 cytokines and their specific transcription factors in human helper T cell clones., Immunology and Cell Biology, 83, 536-541, 2005
- GATA-3 suppresses IFN-gamma promoter activity independently of binding to cis-regulatory elements., FEBS Letters, 570, 63-68, 2004
- Interaction with monocytes enhances IL-5 gene transcription in peripheral T cells of asthmatic patients., International Archives of Allergy and Immunology, 131, S20-25, 2003
- Vav-induced activation of the human IFN-gamma gene promoter is mediated by upregulation of AP-1 activity., FEBS Letters, 514, 153-158, 2002
- Transient contribution of mast cells to pulmonary eosinophilia but not to hyperresponsiveness., Clinical and Experimental Allergy, 32, 475-483, 2002
- Potential initiation of eosinophilic skin inflammation by antigen-specific T helper type 2 cells., International Archives of Allergy and Immunology, 128, S21-23, 2002
- Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors., Clinical and Experimental Immunology, 128, 460-466, 2002
- Transcriptional regulation of the IL-5 gene in peripheral T cells of asthmatic patients., Clinical and Experimental Immunology, 130, 475-483, 2002
- Correlation between eosinophilia induced by CD4+ T cells and bronchial hyperesponseiveness., International Immunology, 13, 329-339, 2001
- Vav/Rac1-mediated activation of the JNK/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the IL-2 gene promoter., Molecular and Cellular Biology, 21, 3126-3136, 2001
- Humoral immunity is dispensable for the local recruitment of antigen-specific Th2 cells., International Archives of Allergy and Immunology, 125, S17-18, 2001
- Dynamics of antigen-specific helper T cells at the initiation of airway eosinophilic inflammation., European Journal of Immunology, 31, 2669-2679, 2001
- IL-5 synthesis by T cells of allergic subjects is regulated at the transcriptional level., International Archives of Allergy and Immunology, 122, S63-66, 2000
- Control of interleukin-5 production by human helper T cells as a treatment for eosinophilic inflammation: Comparison of in vitro and in vivo effects between selective and nonselective cytokine synthesis inhibitors., The Journal of Allergy and Clinical Immunology, 106, S58-64, 2000
- Transcriptional regulation of IL-5 gene by nontransformed human T cells through the proximal promoter element., Internal Medicine, 39, 618-625, 2000
- Cloned Th cells confer eosinophilic inflammation and bronchial hyperresponsiveness., International Archives of Allergy and Immunology, 118, 136-139, 1999
- Regulatory mechanisms of human T cell IL-5 synthesis: differential roles of the proximal promoter-binding proteins in IL-5 gene transcription., International Archives of Allergy and Immunology, 118, 271-274, 1999
- Transcriptional control of IL-5 gene by human helper T cells: IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis., The Journal of Allergy and Clinical Immunology, 103, S429-436, 1999
- Cyclic AMP suppresses interleukin-5 synthesis by human helper T cells via the downregulation of the calcium mobilization pathway., British Journal of Pharmacology, 127, 521-529, 1999
- p38 MAP kinase regulates human T cell IL-5 synthesis., Journal of Immunology, 163, 4763-4771, 1999
- Primary role of CD4+ T cells and supplemental role of mast cells in allergic pulmonary eosinophilia., International Archives of Allergy and Immunology, 120, S15-18, 1999
- A selective type 4 phosphodiesterase inhibitor, T-440, modulates intracellular cAMP level and interleukin-2 production of Jurkat cells., Immunopharmacology, 38, 247-252, 1998
- A novel anti-allergic drug, betotastine besilate, suppresses interleukin-5 production by human peripheral blood mononuclear cells., Biological & Pharmaceutical Bulletin, 21, 411-413, 1998
- Evidence that cyclosporin A and dexamethasone inhibit allergic airway eosinophilic inflammation via suppression of interleukin-5 synthesis by T cells., British Journal of Pharmacology, 124, 1425-1432, 1998
- IL-5-producing T cells that induce airway eosinophilia and hyperresponsiveness are suppressed by dexamethasone and cyclosporin A in mice., International Archives of Allergy and Immunology, 117, S24-27, 1998
- Prevention of ozone-induced airway hyperresponsiveness and epithelial injury by phosphodiesterase inhibitors in guinea pigs., Environmental Toxicology and Pharmacology, 3, 201-209, 1997
- IL-2-induced IL-5 synthesis, but not proliferation, of human CD4+ T cells is suppressed by FK506., Journal of Immunology, 158, 3659-3665, 1997
- Effect of T-440, a novel type IV phosphodiesterase inhibitor, on allergen-induced immediate and late asthmatic reaction and leukocyte infiltration into the airways of guinea pigs., International Archives of Allergy and Immunology, 112, 406-411, 1997
- Two distinct pathways of IL-5 synthesis in allergen-specific human T cell clones are suppressed by glucocorticoids., Blood, 89, 2891-2900, 1997
- Successful transfer of late phase eosinophil infiltration in the lung by infusion of helper T cell clones., American Journal of Respiratory Cell and Molecular Biology, 16, 448-454, 1997
- Dissection of human IL-5 promoter--essential role of CLEO element in human IL-5 gene transcription., International Archives of Allergy and Immunology, 113, 272-274, 1997
- Selective suppression of IL-5 synthesis by OM-01--pinpoint treatment of atopic diseases by IL-5 gene transcription inhibitor., International Archives of Allergy and Immunology, 113, 331-334, 1997
- Two differential effects of cyclic AMP on IL-5 production by antigen-specific human T cell line., The Journal of Pharmacology and Experimental Therapeutics, 283, 345-349, 1997
- Development of lung eosinophilic inflammation by the infusion of IL-5-producing T cell clones., International Archives of Allergy and Immunology, 114, S10-13, 1997
- Control of allergic diseases by regulation of cytokine gene transcription., Arbeiten aus dem Paul-Ehrlich-Institut zu Frankfurt A.M, 91, 209-221, 1997
- Angiotensin-converting enzyme inhibitors can potentiate ozone-induced airway hyperresponsiveness., European Journal of Pharmacology, 337, 259-265, 1997
- Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: A study with allergen—specific human helper T cells., The Journal of Allergy and Clinical Immunology, 100, S56-64, 1997
- Bronchial anti-spasmogenic effects and its selectivity of T-440, phosphodiesterase type 4 inhibitor, in the dog., Biological & Pharmaceutical Bulletin, 20, 1261-1265, 1997
- Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans., Journal of Medicinal Chemistry, 39, 2696-2704, 1996
- IL-15 promotes cytokine production of human T helper cells., Journal of Immunology, 156, 2400-2405, 1996
- Interleukin-5 production by peripheral blood mononuclear cells of asthmatic patients is suppressed by T-440: relation to phosphodiesterase inhibition., The Journal of Pharmacology and Experimental Therapeutics, 279, 240-246, 1996
- Inhibitory effect of a novel phosphodiesterase IV inhibitor, T-440 on antigen- and chemical mediator-induced bronchoconstrictions in guinea pigs in vivo., Japanese Journal of Pharmacology, 72, 1-8, 1996
- A novel phosphodiesterase inhibitor, T-440; possible management of eosinophilic inflammation by down-regulation of Interleukin-5 production., International Archives of Allergy and Immunology, 111, S16-18, 1996
- A critical role of IL-2 for the production and gene transcription of IL-5 in allergen-specific human T cell clones., International Immunology, 8, 1889-1895, 1996
- IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A., International Immunology, 7, 449-457, 1995
- Allergen-specific human T cell clones produce interleukin-5 upon stimulation with the Th1 cytokine interleukin-2., International Archives of Allergy and Immunology, 107, 220-222, 1995
- Analysis of human interleukin-5 gene transcription by T cell clones and hybridomas., International Archives of Allergy and Immunology, 107(1-3), 1995
- Importance of impairment of the airway epithelium for ozone-induced airway hyperresponsiveness in guinea pigs., Japanese Journal of Pharmacology, 67, 375-382, 1995
- Difference among angiotensin-converting enzyme inhibitors in potentiating effects on bradykinin-induced microvascular leakage in guinea pig airways., Japanese Journal of Pharmacology, 69, 111-118, 1995
- Regulation of interleukin-5 production by peripheral blood mononuclear cells from atopic patients with FK506, cyclosporin A and glucocorticoid., International Archives of Allergy and Immunology, 104, S32-35, 1994
- Reflex activities of the upper airway muscles during experimental nasal occlusion in anesthetized dogs., The Journal of Veterinary Medical Science, 53, 93-99, 1991
Publications such as books
- 2004, Immunology 2004, Comparative analysis for calcineurin binding activity of NFAT family members., Medimond International Proceedings, 2004
- 1996, New Horizons in Allergy and Immunotherapy, Enhanced production and gene expression of IL-5 in bronchial asthma: Possible management of atopic diseases with IL-5 specific gene transcription inhibitor., Plenum Publishing Corporation, 1996
Social Activities
History as Committee Members
- Editor, Internatinal Journal of Moleculer Science, 2020/10, 2023/03
- Editor, Translational and Regulatory Sciences, 2019/08, 2023/03
- Editor, Experimental Animals, 2018/04, 2023/03