OSAMU KAMINUMA

Last Updated :2024/07/05

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Professor
E-mail
okamihiroshima-u.ac.jp
Self-introduction
Development of mouse models useful to create novel treatments for various diseases

Basic Information

Academic Degrees

  • The University of Tokyo

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Radiation Biology and Medicine

Research Fields

  • Agricultural sciences;Animal life science;Veterinary medical science
  • Medicine,dentistry, and pharmacy;Basic medicine;Immunology
  • Agricultural sciences;Boundary agriculture;Applied molecular and cellular biology
  • Medicine,dentistry, and pharmacy;Pharmacy;Biological pharmacy

Research Keywords

  • Experimental Animals, Immunology, Genetic modification, Somatic cell clone, Artificial chromosome, T cell, Allergy

Affiliated Academic Societies

  • Japanese Association for Laboratory Animal Science
  • Japanese Society for Immunology
  • Japanese Society of Allergology
  • The Japanese Biochemical Society
  • The Japanese Pharmacological Society
  • The Workshop on Eosinophils in Allergy and Related Diseases
  • The Japanese Society of Veterinary Science
  • Japanese Society of Occupational and Environmental Allergy
  • Japanese Association for Laboratory Animal Medicine
  • Japan Allergy Foundation
  • The American Association of Immunologists
  • The American Society for Biochemistry and Molecular Biology

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 1Term, Foundation biology for life science
  2. 2024, Undergraduate Education, Intensive, Practice for medical research
  3. 2024, Undergraduate Education, 2Term, Outline of Immunology
  4. 2024, Graduate Education (Master's Program) , First Semester, Seminar
  5. 2024, Graduate Education (Master's Program) , Second Semester, Seminar
  6. 2024, Graduate Education (Master's Program) , First Semester, Research
  7. 2024, Graduate Education (Master's Program) , Second Semester, Research
  8. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  9. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  10. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  11. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  12. 2024, Graduate Education (Doctoral Program) , 1Term, Integrated Radiation Medical Science
  13. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Disease Model
  14. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Disease Model
  15. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Disease Model
  16. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Disease Model
  17. 2024, Graduate Education (Doctoral Program) , Second Semester, Introduction to Radiation Biology

Research Activities

Academic Papers

  1. Structure-activity relationship studies of pyrogallol as a calcineurin/NFAT signaling suppressor, Journal of Pharmacological Sciences, 155, 140-147, 202406
  2. Involvement of CCR5 on interstitial macrophages in the development of lung fibrosis in severe asthma., International Immunopharmacology, 202405
  3. Alpha7 Nicotinic Acetylcholine Receptor Agonist Attenuates Allergen-induced Immediate Nasal Response in Murine Model of Allergic Rhinitis, Journal of Veterinary Medical Science, 202405
  4. Nesprin1 deficiency is associated with poor prognosis of renal cell carcinoma and resistance to sunitinib treatment, Oncology, 202401
  5. JPH203, a LAT1 inhibitor, alleviates steroid-resistant murine airway inflammation mediated by Th17 cells, Allergy, 78, 2780-2783, 202306
  6. Generation of reporter mice for detecting the transcriptional activity of nuclear factor of activated T cells, Exprerimental Animals, 202304
  7. Evolutionary mechanisms underlying the diversification of nuclear factor of activated T cells across vertebrates, Scientific Reports, 13, 6468, 202305
  8. Suppressive Effect of Lactococcus lactis subsp. cremoris YRC3780 on a Murine Model of Japanese Cedar Pollinosis, PATHOGENS, 11(11), 202211
  9. Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness, JOURNAL OF PHARMACOLOGICAL SCIENCES, 150(4), 275-278, 202212
  10. BACH1 promotes clear cell renal cell carcinoma progression via upregulating oxidative stress-related tumorigenicity., Cancer Science, 114, 436-448, 202209
  11. DDX41 expression is associated with tumor necrosis in clear cell renal cell carcinoma and in cooperation with VHL loss leads to worse prognosis., Urologic Oncology, 40(10), 456.e9-456.e18, 202207
  12. Th17-Dependent Nasal Hyperresponsiveness Is Mitigated by Steroid Treatment, BIOMOLECULES, 12(5), 202205
  13. Regulation of Th2 responses by Lactococcus lactis subsp. cremoris YRC3780 alleviates DNCB-induced atopic dermatitis in the mouse model, JOURNAL OF FUNCTIONAL FOODS, 94, 202207
  14. Therapeutic Potential for Intractable Asthma by Targeting L-Type Amino Acid Transporter 1, BIOMOLECULES, 12(4), 202204
  15. Expression and Function of Nicotinic Acetylcholine Receptors in Induced Regulatory T Cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(3), 202202
  16. Suppressive effect of dexamethasone on murine Th9 cell-mediated nasal eosinophlic inflammation, ASIA PACIFIC ALLERGY, 11(3), 202107
  17. L-type amino acid transporter 1 inhibitor suppresses murine Th2 cell-mediated bronchial hyperresponsiveness independently of eosinophil accumulation, ASIA PACIFIC ALLERGY, 11(3), 202107
  18. Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(5), 202103
  19. Sublingual Immunotherapy: How Sublingual Allergen Administration Heals Allergic Diseases; Current Perspective about the Mode of Action, PATHOGENS, 10(2), 202102
  20. Progress of genome editing technology and developmental biology useful for radiation research, Journal of Radiation Research, 62, i53-i63, 2021
  21. Sublingual immunotherapy: how sublingual allergen administration heals allergic diseases; current perspective about the mode of action, Pathogens, 10(2), 147, 2021
  22. Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development, International Journal of Molecular Science, 22, 2725, 2021
  23. Suppressive effect of dexamethasone on murine Th9 cell-mediated nasal eosinophilic inflammation, Asia Pacific Allergy, 11, e25, 2021
  24. L-type amino acid transporter 1 inhibitor suppresses murine Th2 cell-mediated bronchial hyperresponsiveness independently of eosinophil accumulation, Asia Pacific Allergy, 11, e33, 202107
  25. Role of CD4(+) T Cells in Allergic Airway Diseases: Learning from Murine Models, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(20), 202010
  26. Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression, JOURNAL OF MEDICAL INVESTIGATION, 67(3-4), 289-297, 202008
  27. Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction, CLINICAL CANCER RESEARCH, 26(8), 2065-2079, 202004
  28. Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation, ASIA PACIFIC ALLERGY, 10(2), 202004
  29. Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production, INTERNATIONAL IMMUNOLOGY, 32(3), 187-201, 202003
  30. LAT1-specific inhibitor is effective against T cell-mediated allergic skin inflammation, ALLERGY, 75(2), 463-467, 202002
  31. Association of Basophil-Expressing Genes with Effectiveness of Sublingual Immunotheraphy, JOURNAL OF NIPPON MEDICAL SCHOOL, 87(1), 49-52, 202002
  32. Identification of novel interacting regions involving calcineurin and nuclear factor of activated T cells, FASEB JOURNAL, 34(2), 3197-3208, 202002
  33. T Cell-Mediated Nasal Hyperresponsiveness in Allergic Rhinitis, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 43(1), 36-40, 202001
  34. LAT1-specific inhibitor is effective against T cell-mediated allergic skin inflammation., Allergy, 75, 463-467, 2020
  35. Basophil-expressing genes related with the efficacy of sublingual immunotherapy., Journal of Nippon Medical School, 87(49-52), 2020
  36. T cell-mediated nasal hyperresponsiveness in allergic rhinitis., Biological and Pharmaceutical Bulletin, 43, 36-40, 2020
  37. Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production., International Immunology, 32, 187-201, 2020
  38. L-type amino acid transporter 1 (LAT1)-specific inhibitor is effective against T cell-mediated nasal hyperresponsiveness., Allergology International, 69(3), 455-458, 2020
  39. Identification of novel interacting regions involving calcineurin and nuclear factor of activated T cells., FASEB Journal, 34, 3197-3208, 2020
  40. Kdm6a deficiency activates inflammatory pathways, promotes M2 macrophage polarization and causes bladder cancer in cooperation with p53 dysfunction., Clinical Cancer Research, 26(8), 2065-2079, 2020
  41. Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation, Asia Pacific Allergy, 10(2), e18, 2020
  42. Epicutaneous allergen administration without antigen delivery device induces local T cell response and alleviates food allergic enteropathy., Allergology International, 69, 622-625, 2020
  43. Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression, Journal of Medical Investigation, 67(3-4), 289-297, 2020
  44. Role of CD4+ T Cells in Allergic Airway Diseases: Learning from Murine Models, International Journal of Molecular Science, 21(20), 7480, 2020
  45. Thrombospondin 1-mediated suppression of mast cell degranulation is involved in the efficacy of sublingual immunotherapy., Allergology International, 68, S9-10, 2019
  46. Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness., International Journal of Molecular Sciences, 20, 2980, 2019
  47. T-Helper Type 2 Cells Direct Antigen-Induced Eosinophilic Skin Inflammation in Mice., Allergy, asthma & immunology Research, 10, 77-82, 2018
  48. Down-regulation of NFAT3 due to lack of T-box transcription factor TBX5 is crucial for cytokine expression in T cells., Journal of Immunology, 200, 92-100, 2018
  49. Contribution of neuraminidase 3 to the differentiation of induced regulatory T cells., Genes to Cells, 23, 112-116, 2018
  50. Involvement of taste receptors in the effectiveness of sublingual immunotherapy., Allergology International, 67, 421-424, 2018
  51. Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis., Allergology International, 67, S25-31, 2018
  52. Microarray-Based Multivariate Analysis of the Effectiveness of Sublingual Immunotherapy for Cedar Pollinosis., Allergy, Asthma & Immunology Research, 10, 562-569, 2018
  53. Serum Cytokine Interactions Are Implicated in the Mechanism of Action of Sublingual Immunotherapy for Japanese Cedar Pollinosis., Journal of Nippon Medical School, 85, 250-258, 2018
  54. Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA., Journal of Autoimmunity, 80, 28-38, 2017
  55. ★, Hyper-reactive cloned mice generated by direct nuclear transfer of antigen-specific CD4+ T cells., EMBO Reports, 18, 885-893, 2017
  56. Identification of biomarker sets for predicting the efficacy of sublingual immunotherapy against pollen-induced allergic rhinitis., International Immunology, 29, 291-300, 2017
  57. Th9 cells induce steroid-resistant bronchial hyperresponsiveness in mice., Allergol International, 66, S35-40, 2017
  58. Oral administration of ovalbumin after sensitization attenuate symptoms in a mouse model of food allergic enteropathy., Bioscience, Biotechnology, and Biochemistry, 81, 1901-1972, 2017
  59. Differential Contribution of Adhesion Molecules to Th1 and Th2 Cell-Mediated Lung and Bowel Inflammation., Biological & Pharmaceutical Bulletin, 40, 1081-1805, 2017
  60. Essential Contribution of CD4+ T Cells to Antigen-Induced Nasal Hyperresponsiveness in Experimental Allergic Rhinitis., PloS One, 11, e0146686, 2016
  61. Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner., PloS One, 11, e0150244, 2016
  62. Critical role of CD44 in antigen-induced Th2- but not Th17-mediated murine airway inflammation., Allergology International, 65, S59-61, 2016
  63. Th9 cells elicit eosinophil-independent bronchial hyperresponsiveness in mice., Allergology International, 65, S24-29, 2016
  64. Crosstalk between histamine and T cells in allergic diseases., Curr Immunol Rev, 2016
  65. Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS)., Journal of Clinical Immunology, 35, 661-667, 2015
  66. Selective suppression of Th2 cell-mediated lung eosinophilic inflammation by anti-major facilitator super family domain containing 10 monoclonal antibody., Allergology International, 63, S29-35, 2014
  67. Antigen-induced mixed and separated inflammation in murine upper and lower airways., Allergology International, 63, S59-61, 2014
  68. Food Allergen-induced IgE Response Mouse Model Created by Injection of in vitro Differentiated Th2 Cell Culture and Oral Antigen Intake., Bioscience of Microbiota, Food and Health, 33, 41-46, 2014
  69. IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages., Journal of Pharmacological Sciences, 125, 394-405, 2014
  70. Transgenic plants for allergen-specific immunotherapy., World J Immunol, 4, 141-148, 2014
  71. Oral immunotherapy with transgenic rice seed containing destructed Japanese cedar pollen allergens, Cry j 1 and Cry j 2, against Japanese cedar pollinosis., Plant Biotechnology Journal, 11, 66-76, 2013
  72. Identification of Acyl-CoA thioesterase in mouse mesenteric lymph nodes., Biological & Pharmaceutical Bulletin, 36, 866-871, 2013
  73. A contraction assay system using primary cultured mouse bronchial smooth muscle cells., International Archives of Allergy and Immunology, 161, S93-97, 2013
  74. Existence of antigen-specific IgE is not sufficient for allergic nasal eosinophil infiltration in mice., International Archives of Allergy and Immunology, 161, S125-128, 2013
  75. Oral immunotherapy for allergic diseases using transgenic rice seeds: current state and future prospects., International Archives of Allergy and Immunology, 161, S164-169, 2013
  76. Selective down-regulation of Th2 cell-mediated airway inflammation in mice by pharmacological intervention of CCR4., Clinical and Experimental Allergy, 42, 315-325, 2012
  77. Murine T cell-derived contractile activity for bronchial smooth muscle cells., International Archives of Allergy and Immunology, 158, S7-10, 2012
  78. NFAT1 and NFAT2 differentially regulate IL-17A expression in human T cells., International Archives of Allergy and Immunology, 158, S30-34, 2012
  79. Inhibition of allergen-induced airway inflammation by low-dose oral immunotherapy with transgenic rice seeds independently of immunoglobulin e synthesis., International Archives of Allergy and Immunology, 158, S66-69, 2012
  80. Protein phosphatase 1 is involved in IL-2-induced IL-5 and IL-13 expression in human T cells., Genes to Cells, 17, 611-618, 2012
  81. Establishment of monoclonal antibodies against a novel eosinophil-specific cell surface molecule, major facilitator super family domain containing 10., Immunology Letters, 147, 80-84, 2012
  82. Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression., Plant Biotechnology Journal, 9, 982-990, 2011
  83. Zinc finger protein, multitype 1 suppresses human Th2 development via downregulation of IL-4., International Archives of Allergy and Immunology, 155, S53-56, 2011
  84. Comparative analysis of steroid sensitivity of Th cells in vitro and in vivo., International Archives of Allergy and Immunology, 155, S110-116, 2011
  85. CD44 is critical for airway accumulation of antigen-specific Th2, but not Th1, cells induced by antigen challenge in mice., European Journal of Immunology, 41, 3198-3207, 2011
  86. Vaccination with transgenic rice seed expressing mite allergen: a new option for asthma sufferers?, Expert Review of Vaccines, 10, 1249-1251, 2011
  87. Selective down-regulation of Th2 cytokines by C-terminal binding protein 2 in human T cells., International Archives of Allergy and Immunology, 152, S18-21, 2010
  88. Effect of sublingual immunotherapy on antigen-induced bronchial and nasal inflammation in mice., International Archives of Allergy and Immunology, 152, S75-78, 2010
  89. Eosinophils are required for the induction of bronchial hyperresponsiveness in a Th-transfer model of Balb/c background., International Archives of Allergy and Immunology, 152, S79-82, 2010
  90. Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition., The Journal of Investigative Dermatology, 130, 2760-2767, 2010
  91. Suppressive role of C-terminal binding protein 1 in IL-4 synthesis in human T cells., Biochemical and Biophysical Research Communications, 382, 326-330, 2009
  92. T-box 21 transcription factor is responsible for distorted TH2 differentiation in human peripheral CD4+ T cells., The Journal of Allergy and Clinical Immunology, 123, 813-823, 2009
  93. Regulation of DNA demethylation during maturation of CD4+ naive T cells by the conserved noncoding sequence 1., Journal of Immunology, 182, 7698-7707, 2009
  94. Murine Th clones confer late asthmatic response upon antigen challenge., International Archives of Allergy and Immunology, 149, S2-6, 2009
  95. Development of transgenic rice expressing mite antigen for a new concept of immunotherapy., International Archives of Allergy and Immunology, 149, S21-24, 2009
  96. Proteomic Approach to FcepsilonRI aggregation-initiated signal transduction cascade in human mast cells., International Archives of Allergy and Immunology, 149, S73-76, 2009
  97. Evaluation of cysteinyl leukotriene-induced contraction of human cultured bronchial smooth muscle cells., International Archives of Allergy and Immunology, 149, S83-86, 2009
  98. Differential contribution of NFATc2 and NFATc1 to TNF-alpha gene expression in T cells., Journal of Immunology, 180, 319-326, 2008
  99. Selective inhibitors of nuclear factor of activated T cells: potential therapeutic drugs for the treatment of immunological and inflammatory diseases., Inflammation & Allergy Drug Targets, 7, 35-40, 2008
  100. Airway eosinophilic inflammation is attenuated in conserved noncoding sequence-1 deficient mice., International Archives of Allergy and Immunology, 146, S2-6, 2008
  101. Downregulation of IL-13 gene transcription by T-bet in human T cells., International Archives of Allergy and Immunology, 146, S33-35, 2008
  102. A contraction assay system using established human bronchial smooth muscle cells., International Archives of Allergy and Immunology, 146, S36-39, 2008
  103. IL-4 gene transcription in human T cells is suppressed by T-bet., International Archives of Allergy and Immunology, 143, S68-70, 2007
  104. IL-9 production by peripheral blood mononuclear cells of atopic asthmatics., International Archives of Allergy and Immunology, 143, S76-79, 2007
  105. Effect of formoterol on allergen-induced cytokine synthesis by atopic asthmatics., International Archives of Allergy and Immunology, 143, S106-109, 2007
  106. Selective suppression of Th2 cell-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists., International Immunology, 19, 913-921, 2007
  107. Functional chemokine receptors in allergic diseases: is CCR8 a novel therapeutic target?, Mini Reviews in Medicinal Chemistry, 6, 463-466, 2006
  108. Characterization of binding activity between nuclear factor of activated T cells and calcineurin by amplified luminescent proximity homogeneous assay., Journal of Immunological Methods, 312, 105-110, 2006
  109. IL-2-induced IL-13 production by allergen-specific human helper T cell clones., International Archives of Allergy and Immunology, 140, S51-54, 2006
  110. Th2 cell-mediated chemokine synthesis is involved in allergic airway inflammation in mice., International Archives of Allergy and Immunology, 140, S55-58, 2006
  111. Genetic factors in the treatment of bronchial asthma., Expert Review of Clinical Immunology, 2, 727-735, 2006
  112. Role of GATA-3 in IL-5 gene transcription by CD4+ T cells of asthmatic patients., International Archives of Allergy and Immunology, 137, S55-59, 2005
  113. Correlation between mRNA expression in Th1/Th2 cytokines and their specific transcription factors in human helper T cell clones., Immunology and Cell Biology, 83, 536-541, 2005
  114. GATA-3 suppresses IFN-gamma promoter activity independently of binding to cis-regulatory elements., FEBS Letters, 570, 63-68, 2004
  115. Interaction with monocytes enhances IL-5 gene transcription in peripheral T cells of asthmatic patients., International Archives of Allergy and Immunology, 131, S20-25, 2003
  116. Vav-induced activation of the human IFN-gamma gene promoter is mediated by upregulation of AP-1 activity., FEBS Letters, 514, 153-158, 2002
  117. Transient contribution of mast cells to pulmonary eosinophilia but not to hyperresponsiveness., Clinical and Experimental Allergy, 32, 475-483, 2002
  118. Potential initiation of eosinophilic skin inflammation by antigen-specific T helper type 2 cells., International Archives of Allergy and Immunology, 128, S21-23, 2002
  119. Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors., Clinical and Experimental Immunology, 128, 460-466, 2002
  120. Transcriptional regulation of the IL-5 gene in peripheral T cells of asthmatic patients., Clinical and Experimental Immunology, 130, 475-483, 2002
  121. Correlation between eosinophilia induced by CD4+ T cells and bronchial hyperesponseiveness., International Immunology, 13, 329-339, 2001
  122. Vav/Rac1-mediated activation of the JNK/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the IL-2 gene promoter., Molecular and Cellular Biology, 21, 3126-3136, 2001
  123. Humoral immunity is dispensable for the local recruitment of antigen-specific Th2 cells., International Archives of Allergy and Immunology, 125, S17-18, 2001
  124. Dynamics of antigen-specific helper T cells at the initiation of airway eosinophilic inflammation., European Journal of Immunology, 31, 2669-2679, 2001
  125. IL-5 synthesis by T cells of allergic subjects is regulated at the transcriptional level., International Archives of Allergy and Immunology, 122, S63-66, 2000
  126. Control of interleukin-5 production by human helper T cells as a treatment for eosinophilic inflammation: Comparison of in vitro and in vivo effects between selective and nonselective cytokine synthesis inhibitors., The Journal of Allergy and Clinical Immunology, 106, S58-64, 2000
  127. Transcriptional regulation of IL-5 gene by nontransformed human T cells through the proximal promoter element., Internal Medicine, 39, 618-625, 2000
  128. Cloned Th cells confer eosinophilic inflammation and bronchial hyperresponsiveness., International Archives of Allergy and Immunology, 118, 136-139, 1999
  129. Regulatory mechanisms of human T cell IL-5 synthesis: differential roles of the proximal promoter-binding proteins in IL-5 gene transcription., International Archives of Allergy and Immunology, 118, 271-274, 1999
  130. Transcriptional control of IL-5 gene by human helper T cells: IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis., The Journal of Allergy and Clinical Immunology, 103, S429-436, 1999
  131. Cyclic AMP suppresses interleukin-5 synthesis by human helper T cells via the downregulation of the calcium mobilization pathway., British Journal of Pharmacology, 127, 521-529, 1999
  132. p38 MAP kinase regulates human T cell IL-5 synthesis., Journal of Immunology, 163, 4763-4771, 1999
  133. Primary role of CD4+ T cells and supplemental role of mast cells in allergic pulmonary eosinophilia., International Archives of Allergy and Immunology, 120, S15-18, 1999
  134. A selective type 4 phosphodiesterase inhibitor, T-440, modulates intracellular cAMP level and interleukin-2 production of Jurkat cells., Immunopharmacology, 38, 247-252, 1998
  135. A novel anti-allergic drug, betotastine besilate, suppresses interleukin-5 production by human peripheral blood mononuclear cells., Biological & Pharmaceutical Bulletin, 21, 411-413, 1998
  136. Evidence that cyclosporin A and dexamethasone inhibit allergic airway eosinophilic inflammation via suppression of interleukin-5 synthesis by T cells., British Journal of Pharmacology, 124, 1425-1432, 1998
  137. IL-5-producing T cells that induce airway eosinophilia and hyperresponsiveness are suppressed by dexamethasone and cyclosporin A in mice., International Archives of Allergy and Immunology, 117, S24-27, 1998
  138. Prevention of ozone-induced airway hyperresponsiveness and epithelial injury by phosphodiesterase inhibitors in guinea pigs., Environmental Toxicology and Pharmacology, 3, 201-209, 1997
  139. IL-2-induced IL-5 synthesis, but not proliferation, of human CD4+ T cells is suppressed by FK506., Journal of Immunology, 158, 3659-3665, 1997
  140. Effect of T-440, a novel type IV phosphodiesterase inhibitor, on allergen-induced immediate and late asthmatic reaction and leukocyte infiltration into the airways of guinea pigs., International Archives of Allergy and Immunology, 112, 406-411, 1997
  141. Two distinct pathways of IL-5 synthesis in allergen-specific human T cell clones are suppressed by glucocorticoids., Blood, 89, 2891-2900, 1997
  142. Successful transfer of late phase eosinophil infiltration in the lung by infusion of helper T cell clones., American Journal of Respiratory Cell and Molecular Biology, 16, 448-454, 1997
  143. Dissection of human IL-5 promoter--essential role of CLEO element in human IL-5 gene transcription., International Archives of Allergy and Immunology, 113, 272-274, 1997
  144. Selective suppression of IL-5 synthesis by OM-01--pinpoint treatment of atopic diseases by IL-5 gene transcription inhibitor., International Archives of Allergy and Immunology, 113, 331-334, 1997
  145. Two differential effects of cyclic AMP on IL-5 production by antigen-specific human T cell line., The Journal of Pharmacology and Experimental Therapeutics, 283, 345-349, 1997
  146. Development of lung eosinophilic inflammation by the infusion of IL-5-producing T cell clones., International Archives of Allergy and Immunology, 114, S10-13, 1997
  147. Control of allergic diseases by regulation of cytokine gene transcription., Arbeiten aus dem Paul-Ehrlich-Institut zu Frankfurt A.M, 91, 209-221, 1997
  148. Angiotensin-converting enzyme inhibitors can potentiate ozone-induced airway hyperresponsiveness., European Journal of Pharmacology, 337, 259-265, 1997
  149. Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: A study with allergen—specific human helper T cells., The Journal of Allergy and Clinical Immunology, 100, S56-64, 1997
  150. Bronchial anti-spasmogenic effects and its selectivity of T-440, phosphodiesterase type 4 inhibitor, in the dog., Biological & Pharmaceutical Bulletin, 20, 1261-1265, 1997
  151. Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans., Journal of Medicinal Chemistry, 39, 2696-2704, 1996
  152. IL-15 promotes cytokine production of human T helper cells., Journal of Immunology, 156, 2400-2405, 1996
  153. Interleukin-5 production by peripheral blood mononuclear cells of asthmatic patients is suppressed by T-440: relation to phosphodiesterase inhibition., The Journal of Pharmacology and Experimental Therapeutics, 279, 240-246, 1996
  154. Inhibitory effect of a novel phosphodiesterase IV inhibitor, T-440 on antigen- and chemical mediator-induced bronchoconstrictions in guinea pigs in vivo., Japanese Journal of Pharmacology, 72, 1-8, 1996
  155. A novel phosphodiesterase inhibitor, T-440; possible management of eosinophilic inflammation by down-regulation of Interleukin-5 production., International Archives of Allergy and Immunology, 111, S16-18, 1996
  156. A critical role of IL-2 for the production and gene transcription of IL-5 in allergen-specific human T cell clones., International Immunology, 8, 1889-1895, 1996
  157. IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A., International Immunology, 7, 449-457, 1995
  158. Allergen-specific human T cell clones produce interleukin-5 upon stimulation with the Th1 cytokine interleukin-2., International Archives of Allergy and Immunology, 107, 220-222, 1995
  159. Analysis of human interleukin-5 gene transcription by T cell clones and hybridomas., International Archives of Allergy and Immunology, 107(1-3), 1995
  160. Importance of impairment of the airway epithelium for ozone-induced airway hyperresponsiveness in guinea pigs., Japanese Journal of Pharmacology, 67, 375-382, 1995
  161. Difference among angiotensin-converting enzyme inhibitors in potentiating effects on bradykinin-induced microvascular leakage in guinea pig airways., Japanese Journal of Pharmacology, 69, 111-118, 1995
  162. Regulation of interleukin-5 production by peripheral blood mononuclear cells from atopic patients with FK506, cyclosporin A and glucocorticoid., International Archives of Allergy and Immunology, 104, S32-35, 1994
  163. Reflex activities of the upper airway muscles during experimental nasal occlusion in anesthetized dogs., The Journal of Veterinary Medical Science, 53, 93-99, 1991

Publications such as books

  1. 2004, Immunology 2004, Comparative analysis for calcineurin binding activity of NFAT family members., Medimond International Proceedings, 2004
  2. 1996, New Horizons in Allergy and Immunotherapy, Enhanced production and gene expression of IL-5 in bronchial asthma: Possible management of atopic diseases with IL-5 specific gene transcription inhibitor., Plenum Publishing Corporation, 1996

Social Activities

History as Committee Members

  1. Editor, Internatinal Journal of Moleculer Science, 2020/10, 2023/03
  2. Editor, Translational and Regulatory Sciences, 2019/08, 2024/03
  3. Editor, Experimental Animals, 2018/04, 2024/03