宿南 知佐CHISA SHUKUNAMI
Last Updated :2021/03/01
- 所属・職名
- 大学院医系科学研究科(歯) 教授
- ホームページ
- メールアドレス
- shukunam
hiroshima-u.ac.jp
基本情報
主な職歴
- 1998年09月01日, 2007年03月31日, 京都大学, 助教授, 再生医科学研究所
- 2013年07月23日, 2019年03月31日, 広島大学, 大学院医歯薬保健学研究院, 教授
- 2007年04月01日, 2013年07月22日, 京都大学, 再生医科学研究所, 准教授
学歴
- 大阪大学, 歯学研究科, 日本, 1991年04月, 1995年03月
- 広島大学, 歯学部, 日本, 1985年04月, 1991年03月
学位
教育担当
担当主専攻プログラム
- 歯学プログラム
- 口腔保健学プログラム
- 口腔工学プログラム
研究分野
- 医歯薬学 / 歯学 / 機能系基礎歯科学
- 生物学 / 生物科学 / 機能生物化学
- 医歯薬学 / 外科系臨床医学 / 整形外科学
- 生物学 / 生物科学 / 発生生物学
所属学会
教育活動
授業担当
- 2020年, 教養教育, 2ターム, 全身の健康と口腔科学I[1歯][旧パッケージ]
- 2020年, 学部専門, 4ターム, 生命科学
- 2020年, 学部専門, 1ターム, 口腔生化学I
- 2020年, 学部専門, 2ターム, 口腔生化学II
- 2020年, 学部専門, 3ターム, 口腔生化学実習
- 2020年, 学部専門, 3ターム, 医科歯科分子生物学
- 2020年, 学部専門, 4ターム, 基礎ゲノム医学
- 2020年, 学部専門, 4ターム, リサーチスタートアップ
- 2020年, 学部専門, 2ターム, 歯学研究特論II
- 2020年, 学部専門, セメスター(前期), 口腔機能学基礎実習
- 2020年, 学部専門, セメスター(前期), 歯学研究実習
- 2020年, 学部専門, セメスター(後期), 歯学研究実習
- 2020年, 学部専門, 1ターム, 基礎栄養生化学
- 2020年, 学部専門, 4ターム, リサーチスタートアップ
- 2020年, 学部専門, 1ターム, 基礎栄養生化学
- 2020年, 学部専門, 4ターム, リサーチスタートアップ
- 2020年, 博士課程・博士課程後期, セメスター(前期), 研究方法特論
- 2020年, 博士課程・博士課程後期, セメスター(前期), 研究方法特論
- 2020年, 博士課程・博士課程後期, セメスター(前期), 研究方法特論
- 2020年, 博士課程・博士課程後期, セメスター(前期), 研究方法特論
- 2020年, 修士課程・博士課程前期, セメスター(前期), 特別研究
- 2020年, 博士課程・博士課程後期, セメスター(前期), 口腔生化学特別演習
- 2020年, 博士課程・博士課程後期, セメスター(後期), 口腔生化学特別演習
- 2020年, 博士課程・博士課程後期, セメスター(前期), 口腔生化学特別実験
- 2020年, 博士課程・博士課程後期, セメスター(後期), 口腔生化学特別実験
- 2020年, 修士課程・博士課程前期, セメスター(前期), 特別演習
- 2020年, 修士課程・博士課程前期, セメスター(後期), 特別演習
- 2020年, 修士課程・博士課程前期, セメスター(後期), 特別研究
- 2020年, 博士課程・博士課程後期, セメスター(前期), 特別演習
- 2020年, 博士課程・博士課程後期, セメスター(後期), 特別演習
- 2020年, 博士課程・博士課程後期, セメスター(前期), 特別研究
- 2020年, 博士課程・博士課程後期, セメスター(後期), 特別研究
- 2020年, 修士課程・博士課程前期, 1ターム, 研究方法論A
- 2020年, 博士課程・博士課程後期, 1ターム, 研究方法論B
- 2020年, 博士課程・博士課程後期, 3ターム, バイオメディカルサイエンスの創生展開
- 2020年, 博士課程・博士課程後期, セメスター(前期), 口腔生化学特別演習
- 2020年, 博士課程・博士課程後期, セメスター(後期), 口腔生化学特別演習
- 2020年, 博士課程・博士課程後期, セメスター(前期), 口腔生化学特別研究
- 2020年, 博士課程・博士課程後期, セメスター(後期), 口腔生化学特別研究
- 2020年, 博士課程・博士課程後期, 2ターム, ゲノム編集先端研究特論B
研究活動
学術論文(★は代表的な論文)
- Transient and lineage-restricted requirement of Ebf3 for sternum ossification, DEVELOPMENT, 147巻, 9号, 202005
- Loss of tenomodulin expression is a risk factor for age-related intervertebral disc degeneration, AGING CELL, 19巻, 3号, 202003
- ★, Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation, サイエンティフィック レポート, 9巻, pp. 4605, 20190314
- Fibroblast Growth Factor 2 Enhances Tendon-to-Bone Healing in a Rat Rotator Cuff Repair of Chronic Tears, AMERICAN JOURNAL OF SPORTS MEDICINE, 47巻, 7号, pp. 1701-1712, 2019
- Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate, CELL REPORTS, 29巻, 3号, pp. 603-+, 20191015
- THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis, JOURNAL OF BONE AND MINERAL METABOLISM, 36巻, 4号, pp. 410-419, 201807
- Host defense against oral microbiota by bone-damaging T cells, NATURE COMMUNICATIONS, 9巻, 20180216
- Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes, SCIENTIFIC REPORTS, 8巻, 20180216
- TGF-beta 1 Improves Biomechanical Strength by Extracellular Matrix Accumulation Without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model, AMERICAN JOURNAL OF SPORTS MEDICINE, 45巻, 10号, pp. 2394-2404, 201708
- Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load, EBIOMEDICINE, 20巻, pp. 240-254, 201706
- Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system, SCIENTIFIC REPORTS, 7巻, 20170322
- Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation, PLOS GENETICS, 12巻, 1号, 2016
- Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal components, JAPANESE DENTAL SCIENCE REVIEW, 52巻, 4号, pp. 84-92, 2016
- Role of MSX1 in Osteogenic Differentiation of Human Dental Pulp Stem Cells, STEM CELLS INTERNATIONAL, 2016
- TENOgenic MODULating INsider factor: systematic assessment on the functions of tenomodulin gene, GENE, 587巻, 1号, pp. 1-17, 20160801
- Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone, DEVELOPMENT, 142巻, 4号, pp. 787-796, 2015
- Scleraxis, 再生医療 用語ハンドブック, pp. 109, 2015
- 腱・靱帯細胞, 再生医療 用語ハンドブック, pp. 106-107, 2015
- Chondromodulin-I, 再生医療 用語ハンドブック, pp. 108, 2015
- Tenomodulin, 再生医療 用語ハンドブック, pp. 108-109, 2015
- 骨の血管・神経, 骨ペディア 骨疾患・骨代謝キーワード事典, pp. 25-29, 2015
- Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells, Stem Cells and Development, 24巻, 5号, pp. 597-609, 201501
- Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change, Biochem Biophys Rep., 3号, pp. 175-189, 2015
- A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis, AMERICAN JOURNAL OF HUMAN GENETICS, 97巻, 2号, pp. 337-342, 20150806
- ★, Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone, DEVELOPMENT, 142巻, 4号, pp. 787-796, 20150215
- The N- Terminal Cleavage of Chondromodulin-I in Growth- Plate Cartilage at the Hypertrophic and Calcified Zones during Bone Development, PLOS ONE, 9巻, 4号, 2014
- Sox9- and Scleraxis-Cre Lineage Fate Mapping in Aortic and Mitral Valve Structures, Journal of Cardiovascular Development and Disease, 1巻, 2号, pp. 163-176, 20140826
- Pax1 acts as a negative regulator of chondrocyte maturation, EXPERIMENTAL CELL RESEARCH, 319巻, 20号, pp. 3128-3139, 2013
- Generation and characterization of ScxCre transgenic mice, GENESIS, 51巻, 4号, pp. 275-283, 2013
- Tenomodulin expression in the periodontal ligament enhances cellular adhesion., PLoS One, 8巻, pp. e60203, 2013
- ★, Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament, DEVELOPMENT, 140巻, 11号, pp. 2280-2288, 2013
- Direct conversion of tenocytes into chondrocytes by Sox9, EXPERIMENTAL CELL RESEARCH, 318巻, 13号, pp. 1492-1507, 2012
- Conversion of Human Bone Marrow-Derived Mesenchymal Stem Cells into Tendon Progenitor Cells by Ectopic Expression of Scleraxis, STEM CELLS AND DEVELOPMENT, 21巻, 6号, pp. 846-858, 2012
- Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis., Stem Cells Dev, 21巻, pp. 846-858, 2012
- Synthetic disulfide-bridged cyclic peptides mimic the anti-angiogenic actions of chondromodulin-I., Cancer Sci, 103巻, pp. 1311-1318, 2012
- Localization of chondromodulin-I at the feto-maternal interface and its inhibitory actions on trophoblast invasion in vitro, BMC CELL BIOLOGY, 12巻, 2011
- A functional role of the glycosylated N-terminal domain of chondromodulin-I, JOURNAL OF BONE AND MINERAL METABOLISM, 29巻, 1号, pp. 23-30, 2011
- Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents (vol 120, pg 2292, 2010), JOURNAL OF CLINICAL INVESTIGATION, 121巻, 1号, pp. 454-454, 2011
- Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents, JOURNAL OF CLINICAL INVESTIGATION, 120巻, 7号, pp. 2292-2306, 2010
- Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor, EXPERIMENTAL CELL RESEARCH, 316巻, 5号, pp. 775-788, 2010
- Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 42巻, 1号, pp. 148-156, 2010
- Gene delivery process in a single animal cell after femtosecond laser microinjection, APPLIED SURFACE SCIENCE, 255巻, 24号, pp. 9880-9884, 2009
- Differential actions of VEGF-A isoforms on perichondrial angiogenesis during endochondral bone formation, DEVELOPMENTAL BIOLOGY, 332巻, 2号, pp. 196-211, 2009
- Altered fracture callus formation in chondromodulin-I deficient mice, BONE, 43巻, 6号, pp. 1047-1056, 2008
- Chordae tendineae cordis are covered and protected by the anti-angiogenic factor, Tenomodulin, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 45巻, pp. S26-S26, 2008
- Local Tenomodulin Absence, Angiogenesis, and Matrix Metalloproteinase Activation Are Associated With the Rupture of the Chordae Tendineae Cordis, CIRCULATION, 118巻, 17号, pp. 1737-1747, 2008
- Cartilaginous features in matrix-producing carcinoma of the breast: four cases report with histochemical and immunohistochemical analysis of matrix molecules, MODERN PATHOLOGY, 21巻, 10号, pp. 1282-1292, 2008
- Nanoparticle injection to single animal cells using femtosecond laser-induced impulsive force, APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 93巻, 1号, pp. 39-43, 2008
- Chondromodulin-I and tenomodulin are differentially expressed in the avascular mesenchyme during mouse and chick development, CELL AND TISSUE RESEARCH, 332巻, 1号, pp. 111-122, 2008
- The anti-angiogenic factor, tenomodulin, has a pivotal role in maintaining avascularity of chordae tendineae cordis, CIRCULATION, 116巻, 16号, pp. 234-234, 2007
- Chondromodulin-I and tenomodulin: The negative control of angiogenesis in connective tissue, CURRENT PHARMACEUTICAL DESIGN, 13巻, 20号, pp. 2101-2112, 2007
- Realignment process of actin stress fibers in single living cells studied by focused femtosecond laser irradiation, APPLIED SURFACE SCIENCE, 253巻, 15号, pp. 6416-6419, 2007
- Immobilization of bioactive fibroblast growth factor-2 into cubic proteinous microcrystals (Bombyx mori cypovirus polyhedra) that are insoluble in a physiological cellular environment, JOURNAL OF BIOLOGICAL CHEMISTRY, 282巻, 23号, pp. 17289-17296, 2007
- Nondestructive micro-patterning of proteinous occlusion bodies in water by femtosecond laser-induced mechanical force, BIOMEDICAL MICRODEVICES, 9巻, 2号, pp. 105-111, 2007
- Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells, JOURNAL OF CELL SCIENCE, 120巻, 5号, pp. 849-857, 2007
- Disruption of chondromodulin-I gene, a potent angioinhibitory factor, causes aortic valve stenosis in mice, CIRCULATION, 114巻, 18号, pp. 326-326, 2006
- Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis, NATURE MEDICINE, 12巻, 10号, pp. 1151-1159, 2006
- ★, Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor., J Cell Biol., 133巻, pp. 457-468, 1996
- Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro., Biochemical and biophysical research communications, 249巻, 3号, 1998
- Sequential progression of the differentiation program by bone morphogenetic protein-2 in chondrogenic cell line ATDC5., Experimental cell research, 241巻, 1号, 1998
- Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans., The Journal of biological chemistry, 273巻, 20号, 1998
- Identification of an autocrine chondrocyte colony-stimulating factor: chondromodulin-I stimulates the colony formation of growth plate chondrocytes in agarose culture., Biochemical and biophysical research communications, 241巻, 2号, 1997
- Identification of chondromodulin I as a novel endothelial cell growth inhibitor. Purification and its localization in the avascular zone of epiphyseal cartilage., The Journal of biological chemistry, 272巻, 51号, 1997
- Inhibition of DNA synthesis and tube morphogenesis of cultured vascular endothelial cells by chondromodulin-I., FEBS letters, 415巻, 3号, 1997
- Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 12巻, 8号, 1997
- Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5., Biochemical and biophysical research communications, 235巻, 1号, 1997
- Stimulation of osteoblast proliferation by the cartilage-derived growth promoting factors chondromodulin-I and -II., FEBS letters, 406巻, 3号, 1997
- [Effect of collagen on magnetization transfer contrast assessed in cultured cartilage]., Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 56巻, 12号, 1996
- A novel growth-promoting factor derived from fetal bovine cartilage, chondromodulin II. Purification and amino acid sequence., The Journal of biological chemistry, 271巻, 37号, 1996
- 1 alpha,25-dihydroxyvitamin D3 inhibits cell growth and chondrogenesis of a clonal mouse EC cell line, ATDC5., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 11巻, 1号, 1996
- Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor., The Journal of cell biology, 133巻, 2号, 1996
- Fibroblast Growth Factor 2 Enhances Tendon-to-Bone Healing in a Rat Rotator Cuff Repair of Chronic Tears., The American journal of sports medicine, 47巻, 7号, 2019
- Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation., Scientific reports, 9巻, 1号, 2019
- [Homeostasis and Disorder of Musculoskeletal System.Enthesis formation and repair:Current understanding and perspectives for the future regenerative therapy.], Clinical calcium, 28巻, 3号
- THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis., Journal of bone and mineral metabolism, 36巻, 4号, 2018
- Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells., PloS one, 12巻, 7号, 2017
- TGF-β1 Improves Biomechanical Strength by Extracellular Matrix Accumulation Without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model., The American journal of sports medicine, 45巻, 10号, 2017
- Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system., Scientific reports, 7巻, 2017
- Differential expression of Tenomodulin and Chondromodulin-1 at the insertion site of the tendon reflects a phenotypic transition of the resident cells., Tissue & cell, 42巻, 2号, 2010
- Minute pleomorphic adenoma of the submandibular gland in patients with oral malignancy: a report of two cases with histological and immunohistochemical examination., Histopathology, 51巻, 2号, 2007
- Immobilization of bioactive fibroblast growth factor-2 into cubic proteinous microcrystals (Bombyx mori cypovirus polyhedra) that are insoluble in a physiological cellular environment., The Journal of biological chemistry, 282巻, 23号, 2007
- Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells., Journal of cell science, 120巻, Pt 5号, 2007
- Nondestructive micro-patterning of proteinous occlusion bodies in water by femtosecond laser-induced mechanical force., Biomedical microdevices, 9巻, 2号, 2007
- Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis., Nature medicine, 12巻, 10号, 2006
- Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes., Developmental biology, 298巻, 1号, 2006
- [Vascular development and cartilage formation]., Clinical calcium, 16巻, 4号, 2006
- Angiogenesis inhibitors localized in hypovascular mesenchymal tissues: chondromodulin-I and tenomodulin., Connective tissue research, 46巻, 1号, 2005
- Chondromodulin-I and tenomodulin: a new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues., Biochemical and biophysical research communications, 333巻, 2号, 2005
- [Chondromodulin-I and its related gene Tenomodulin]., Clinical calcium, 12巻, 3号, 2002
- [Differentiation of cartilage stem cells and their clinical applications]., Clinical calcium, 12巻, 2号, 2002
- Expression and localization of cartilage-specific matrix protein chondromodulin-I mRNA in salivary pleomorphic adenomas., Virchows Archiv : an international journal of pathology, 446巻, 1号, 2005
- Anti-angiogenic action of the C-terminal domain of tenomodulin that shares homology with chondromodulin-I., Journal of cell science, 117巻, Pt 13号, 2004
- Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: therapeutic potential in rheumatoid arthritis., Arthritis and rheumatism, 50巻, 3号, 2004
- Role of cartilage-derived anti-angiogenic factor, chondromodulin-I, during endochondral bone formation., Osteoarthritis and cartilage, 9 Suppl A巻, 2001
- Differentiation of chondrogenic precursor cells during the regeneration of articular cartilage., Osteoarthritis and cartilage, 9 Suppl A巻, 2001
- Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis., Mechanisms of development, 105巻, 1-2号, 2001
- Expression and localization of angiogenic inhibitory factor, chondromodulin-I, in adult rat eye., Investigative ophthalmology & visual science, 42巻, 6号, 2001
- Cartilage-specific matrix protein chondromodulin-I is associated with chondroid formation in salivary pleomorphic adenomas: immunohistochemical analysis., The American journal of pathology, 158巻, 4号, 2001
- Molecular cloning of tenomodulin, a novel chondromodulin-I related gene., Biochemical and biophysical research communications, 280巻, 5号, 2001
- A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells., The Journal of biological chemistry, 276巻, 14号, 2001
- [Angiogenic inducers and inhibitors]., Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 45巻, 13 Suppl号, 2000
- Differential expressions of BMP family genes during chondrogenic differentiation of mouse ATDC5 cells., Cell structure and function, 25巻, 3号, 2000
- Chondromodulin-I as a novel cartilage-specific growth-modulating factor., Pediatric nephrology (Berlin, Germany), 14巻, 7号, 2000
- A novel in vitro culture system for analysis of functional role of phosphate transport in endochondral ossification., Bone, 27巻, 1号, 2000
- Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 15巻, 3号, 2000
- Requirement of autocrine signaling by bone morphogenetic protein-4 for chondrogenic differentiation of ATDC5 cells., FEBS letters, 469巻, 1号, 2000
- Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo., FEBS letters, 458巻, 3号, 1999
- Generation of multiple transcripts from the chicken chondromodulin-I gene and their expression during embryonic development., FEBS letters, 456巻, 1号, 1999
- Spatiotemporal pattern of the mouse chondromodulin-I gene expression and its regulatory role in vascular invasion into cartilage during endochondral bone formation., The International journal of developmental biology, 43巻, 1号, 1999
- Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells., European journal of biochemistry, 260巻, 3号, 1999
- Molecular cloning of mouse and bovine chondromodulin-II cDNAs and the growth-promoting actions of bovine recombinant protein., Journal of biochemistry, 125巻, 3号, 1999
- Transcriptome analysis of early chondrogenesis in ATDC5 cells induced by bone morphogenetic protein 4., Genomics, 83巻, 1号, 2004
- Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes., Investigative ophthalmology & visual science, 44巻, 5号, 2003
- Immunohistochemical evaluation of cartilage-derived morphogenic protein-1 and -2 in normal human salivary glands and pleomorphic adenomas., Virchows Archiv : an international journal of pathology, 442巻, 5号, 2003
- Chondromodulin I is a bone remodeling factor., Molecular and cellular biology, 23巻, 2号, 2003
- Cartilage-specific matrix protein, chondromodulin-I (ChM-I), is a strong angio-inhibitor in endochondral ossification of human neonatal vertebral tissues in vivo: relationship with angiogenic factors in the cartilage., Acta histochemica, 104巻, 2号, 2002
- [Integration of the musculoskeletal components by tendons and ligaments.], Clinical calcium, 27巻, 3号
- Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation., PLoS genetics, 12巻, 1号, 2016
- OASIS modulates hypoxia pathway activity to regulate bone angiogenesis., Scientific reports, 5巻, 2015
- FGF-2 Stimulates the Growth of Tenogenic Progenitor Cells to Facilitate the Generation of Tenomodulin-Positive Tenocytes in a Rat Rotator Cuff Healing Model., The American journal of sports medicine, 43巻, 10号, 2015
- A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis., American journal of human genetics, 97巻, 2号, 2015
- The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development., PloS one, 9巻, 4号, 2014
- Pax1 acts as a negative regulator of chondrocyte maturation., Experimental cell research, 319巻, 20号, 2013
- Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis., Nature genetics, 45巻, 6号, 2013
- Tenomodulin expression in the periodontal ligament enhances cellular adhesion., PloS one, 8巻, 4号, 2013
- Generation and characterization of ScxCre transgenic mice., Genesis (New York, N.Y. : 2000), 51巻, 4号, 2013
- Localization of chondromodulin-I at the feto-maternal interface and its inhibitory actions on trophoblast invasion in vitro., BMC cell biology, 12巻, 2011
- Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents., The Journal of clinical investigation, 120巻, 7号, 2010
- A functional role of the glycosylated N-terminal domain of chondromodulin-I., Journal of bone and mineral metabolism, 29巻, 1号, 2011
- Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor., Experimental cell research, 316巻, 5号, 2010
- Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription., The international journal of biochemistry & cell biology, 42巻, 1号, 2010
- Differential actions of VEGF-A isoforms on perichondrial angiogenesis during endochondral bone formation., Developmental biology, 332巻, 2号, 2009
- Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis., Circulation, 118巻, 17号, 2008
- Altered fracture callus formation in chondromodulin-I deficient mice., Bone, 43巻, 6号, 2008
- Cartilaginous features in matrix-producing carcinoma of the breast: four cases report with histochemical and immunohistochemical analysis of matrix molecules., Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21巻, 10号, 2008
- Chondromodulin-I and tenomodulin are differentially expressed in the avascular mesenchyme during mouse and chick development., Cell and tissue research, 332巻, 1号, 2008
- Chondromodulin-I and tenomodulin: the negative control of angiogenesis in connective tissue., Current pharmaceutical design, 13巻, 20号, 2007
- ★, Direct conversion of tenocytes into chondrocytes by Sox9., Exp Cell Res, 318巻, pp. 1492-1507, 2012
招待講演、口頭・ポスター発表等
- Molecular mechanisms regulating tendon and ligament formation, 宿南 知佐, 第11回 Bone Biology Forum, 2014年08月23日, 招待, 英語, 帝人ファーマ株式会社, 富士教育研究所 (静岡件裾野市)
- 骨格と筋肉を連結する腱の形成を支える分子メカニズム, 宿南 知佐, 第32回日本骨代謝学会学術集会, 2014年07月26日, 招待, 日本語, 島根大学医学部似化学講座 内科学第一
杉本 利嗣, 大阪
受賞
- 2007年, 日本結合組織学会大高賞
- 1995年12月, The 3rd Pan Pacific Connective Tissue Societies Symposium Young Investigator Award
外部資金
競争的資金等の採択状況
- 科学研究費助成事業(基盤研究(B)), 硬組織を連結する組織構築の形成メカニズム, 2014年, 2016年
社会活動
学術会議等の主催
- 2015年10月, 2015年10月
- 第18回運動器科学研究会, 2017年09月