宿南 知佐CHISA SHUKUNAMI

Last Updated :2021/03/01

所属・職名
大学院医系科学研究科（歯）　教授
ホームページ
https://home.hiroshima-u.ac.jp/tnmd/j_html/j_index.html
メールアドレス
shukunamhiroshima-u.ac.jp

基本情報

主な職歴

  • 1998年09月01日, 2007年03月31日, 京都大学, 助教授, 再生医科学研究所
  • 2013年07月23日, 2019年03月31日, 広島大学, 大学院医歯薬保健学研究院, 教授
  • 2007年04月01日, 2013年07月22日, 京都大学, 再生医科学研究所, 准教授

学歴

  • 大阪大学, 歯学研究科, 日本, 1991年04月, 1995年03月
  • 広島大学, 歯学部, 日本, 1985年04月, 1991年03月

学位

  • 博士（歯学）　(大阪大学)

教育担当

  • 【学士課程】 歯学部 : 歯学科

担当主専攻プログラム

  • 歯学プログラム
  • 口腔保健学プログラム
  • 口腔工学プログラム

研究分野

  • 医歯薬学 / 歯学 / 機能系基礎歯科学
  • 生物学 / 生物科学 / 機能生物化学
  • 医歯薬学 / 外科系臨床医学 / 整形外科学
  • 生物学 / 生物科学 / 発生生物学

所属学会

  • 日本骨代謝学会

教育活動

授業担当

  1. 2020年, 教養教育, ２ターム, 全身の健康と口腔科学I[1歯]［旧パッケージ］
  2. 2020年, 学部専門, ４ターム, 生命科学
  3. 2020年, 学部専門, １ターム, 口腔生化学I
  4. 2020年, 学部専門, ２ターム, 口腔生化学II
  5. 2020年, 学部専門, ３ターム, 口腔生化学実習
  6. 2020年, 学部専門, ３ターム, 医科歯科分子生物学
  7. 2020年, 学部専門, ４ターム, 基礎ゲノム医学
  8. 2020年, 学部専門, ４ターム, リサーチスタートアップ
  9. 2020年, 学部専門, ２ターム, 歯学研究特論II
  10. 2020年, 学部専門, セメスター（前期）, 口腔機能学基礎実習
  11. 2020年, 学部専門, セメスター（前期）, 歯学研究実習
  12. 2020年, 学部専門, セメスター（後期）, 歯学研究実習
  13. 2020年, 学部専門, １ターム, 基礎栄養生化学
  14. 2020年, 学部専門, ４ターム, リサーチスタートアップ
  15. 2020年, 学部専門, １ターム, 基礎栄養生化学
  16. 2020年, 学部専門, ４ターム, リサーチスタートアップ
  17. 2020年, 博士課程・博士課程後期, セメスター（前期）, 研究方法特論
  18. 2020年, 博士課程・博士課程後期, セメスター（前期）, 研究方法特論
  19. 2020年, 博士課程・博士課程後期, セメスター（前期）, 研究方法特論
  20. 2020年, 博士課程・博士課程後期, セメスター（前期）, 研究方法特論
  21. 2020年, 修士課程・博士課程前期, セメスター（前期）, 特別研究
  22. 2020年, 博士課程・博士課程後期, セメスター（前期）, 口腔生化学特別演習
  23. 2020年, 博士課程・博士課程後期, セメスター（後期）, 口腔生化学特別演習
  24. 2020年, 博士課程・博士課程後期, セメスター（前期）, 口腔生化学特別実験
  25. 2020年, 博士課程・博士課程後期, セメスター（後期）, 口腔生化学特別実験
  26. 2020年, 修士課程・博士課程前期, セメスター（前期）, 特別演習
  27. 2020年, 修士課程・博士課程前期, セメスター（後期）, 特別演習
  28. 2020年, 修士課程・博士課程前期, セメスター（後期）, 特別研究
  29. 2020年, 博士課程・博士課程後期, セメスター（前期）, 特別演習
  30. 2020年, 博士課程・博士課程後期, セメスター（後期）, 特別演習
  31. 2020年, 博士課程・博士課程後期, セメスター（前期）, 特別研究
  32. 2020年, 博士課程・博士課程後期, セメスター（後期）, 特別研究
  33. 2020年, 修士課程・博士課程前期, １ターム, 研究方法論A
  34. 2020年, 博士課程・博士課程後期, １ターム, 研究方法論B
  35. 2020年, 博士課程・博士課程後期, ３ターム, バイオメディカルサイエンスの創生展開
  36. 2020年, 博士課程・博士課程後期, セメスター（前期）, 口腔生化学特別演習
  37. 2020年, 博士課程・博士課程後期, セメスター（後期）, 口腔生化学特別演習
  38. 2020年, 博士課程・博士課程後期, セメスター（前期）, 口腔生化学特別研究
  39. 2020年, 博士課程・博士課程後期, セメスター（後期）, 口腔生化学特別研究
  40. 2020年, 博士課程・博士課程後期, ２ターム, ゲノム編集先端研究特論B

研究活動

学術論文（★は代表的な論文）

  1. Transient and lineage-restricted requirement of Ebf3 for sternum ossification, DEVELOPMENT, 147巻, 9号, 202005
    DOIを用いた論文検索結果へのリンク
  2. Loss of tenomodulin expression is a risk factor for age-related intervertebral disc degeneration, AGING CELL, 19巻, 3号, 202003
    DOIを用いた論文検索結果へのリンク
  3. ★, Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation, サイエンティフィック レポート, 9巻, pp. 4605, 20190314
  4. Fibroblast Growth Factor 2 Enhances Tendon-to-Bone Healing in a Rat Rotator Cuff Repair of Chronic Tears, AMERICAN JOURNAL OF SPORTS MEDICINE, 47巻, 7号, pp. 1701-1712, 2019
  5. Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate, CELL REPORTS, 29巻, 3号, pp. 603-+, 20191015
    DOIを用いた論文検索結果へのリンク
  6. THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis, JOURNAL OF BONE AND MINERAL METABOLISM, 36巻, 4号, pp. 410-419, 201807
    DOIを用いた論文検索結果へのリンク
  7. Host defense against oral microbiota by bone-damaging T cells, NATURE COMMUNICATIONS, 9巻, 20180216
    DOIを用いた論文検索結果へのリンク
  8. Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes, SCIENTIFIC REPORTS, 8巻, 20180216
    DOIを用いた論文検索結果へのリンク
  9. TGF-beta 1 Improves Biomechanical Strength by Extracellular Matrix Accumulation Without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model, AMERICAN JOURNAL OF SPORTS MEDICINE, 45巻, 10号, pp. 2394-2404, 201708
    DOIを用いた論文検索結果へのリンク
  10. Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load, EBIOMEDICINE, 20巻, pp. 240-254, 201706
    DOIを用いた論文検索結果へのリンク
  11. Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system, SCIENTIFIC REPORTS, 7巻, 20170322
    DOIを用いた論文検索結果へのリンク
  12. Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation, PLOS GENETICS, 12巻, 1号, 2016
  13. Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal components, JAPANESE DENTAL SCIENCE REVIEW, 52巻, 4号, pp. 84-92, 2016
  14. Role of MSX1 in Osteogenic Differentiation of Human Dental Pulp Stem Cells, STEM CELLS INTERNATIONAL, 2016
    DOIを用いた論文検索結果へのリンク
  15. TENOgenic MODULating INsider factor: systematic assessment on the functions of tenomodulin gene, GENE, 587巻, 1号, pp. 1-17, 20160801
    DOIを用いた論文検索結果へのリンク
  16. Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone, DEVELOPMENT, 142巻, 4号, pp. 787-796, 2015
  17. Scleraxis, 再生医療 用語ハンドブック, pp. 109, 2015
  18. 腱・靱帯細胞, 再生医療 用語ハンドブック, pp. 106-107, 2015
  19. Chondromodulin-I, 再生医療 用語ハンドブック, pp. 108, 2015
  20. Tenomodulin, 再生医療 用語ハンドブック, pp. 108-109, 2015
  21. 骨の血管・神経, 骨ペディア 骨疾患・骨代謝キーワード事典, pp. 25-29, 2015
  22. Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells, Stem Cells and Development, 24巻, 5号, pp. 597-609, 201501
  23. Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change, Biochem Biophys Rep., 3号, pp. 175-189, 2015
  24. A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis, AMERICAN JOURNAL OF HUMAN GENETICS, 97巻, 2号, pp. 337-342, 20150806
    DOIを用いた論文検索結果へのリンク
  25. ★, Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone, DEVELOPMENT, 142巻, 4号, pp. 787-796, 20150215
    DOIを用いた論文検索結果へのリンク
  26. The N- Terminal Cleavage of Chondromodulin-I in Growth- Plate Cartilage at the Hypertrophic and Calcified Zones during Bone Development, PLOS ONE, 9巻, 4号, 2014
  27. Sox9- and Scleraxis-Cre Lineage Fate Mapping in Aortic and Mitral Valve Structures, Journal of Cardiovascular Development and Disease, 1巻, 2号, pp. 163-176, 20140826
  28. Pax1 acts as a negative regulator of chondrocyte maturation, EXPERIMENTAL CELL RESEARCH, 319巻, 20号, pp. 3128-3139, 2013
  29. Generation and characterization of ScxCre transgenic mice, GENESIS, 51巻, 4号, pp. 275-283, 2013
  30. Tenomodulin expression in the periodontal ligament enhances cellular adhesion., PLoS One, 8巻, pp. e60203, 2013
  31. ★, Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament, DEVELOPMENT, 140巻, 11号, pp. 2280-2288, 2013
  32. Direct conversion of tenocytes into chondrocytes by Sox9, EXPERIMENTAL CELL RESEARCH, 318巻, 13号, pp. 1492-1507, 2012
  33. Conversion of Human Bone Marrow-Derived Mesenchymal Stem Cells into Tendon Progenitor Cells by Ectopic Expression of Scleraxis, STEM CELLS AND DEVELOPMENT, 21巻, 6号, pp. 846-858, 2012
  34. Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis., Stem Cells Dev, 21巻, pp. 846-858, 2012
  35. Synthetic disulfide-bridged cyclic peptides mimic the anti-angiogenic actions of chondromodulin-I., Cancer Sci, 103巻, pp. 1311-1318, 2012
  36. Localization of chondromodulin-I at the feto-maternal interface and its inhibitory actions on trophoblast invasion in vitro, BMC CELL BIOLOGY, 12巻, 2011
  37. A functional role of the glycosylated N-terminal domain of chondromodulin-I, JOURNAL OF BONE AND MINERAL METABOLISM, 29巻, 1号, pp. 23-30, 2011
  38. Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents (vol 120, pg 2292, 2010), JOURNAL OF CLINICAL INVESTIGATION, 121巻, 1号, pp. 454-454, 2011
  39. Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents, JOURNAL OF CLINICAL INVESTIGATION, 120巻, 7号, pp. 2292-2306, 2010
  40. Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor, EXPERIMENTAL CELL RESEARCH, 316巻, 5号, pp. 775-788, 2010
  41. Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 42巻, 1号, pp. 148-156, 2010
  42. Gene delivery process in a single animal cell after femtosecond laser microinjection, APPLIED SURFACE SCIENCE, 255巻, 24号, pp. 9880-9884, 2009
  43. Differential actions of VEGF-A isoforms on perichondrial angiogenesis during endochondral bone formation, DEVELOPMENTAL BIOLOGY, 332巻, 2号, pp. 196-211, 2009
  44. Altered fracture callus formation in chondromodulin-I deficient mice, BONE, 43巻, 6号, pp. 1047-1056, 2008
  45. Chordae tendineae cordis are covered and protected by the anti-angiogenic factor, Tenomodulin, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 45巻, pp. S26-S26, 2008
  46. Local Tenomodulin Absence, Angiogenesis, and Matrix Metalloproteinase Activation Are Associated With the Rupture of the Chordae Tendineae Cordis, CIRCULATION, 118巻, 17号, pp. 1737-1747, 2008
  47. Cartilaginous features in matrix-producing carcinoma of the breast: four cases report with histochemical and immunohistochemical analysis of matrix molecules, MODERN PATHOLOGY, 21巻, 10号, pp. 1282-1292, 2008
  48. Nanoparticle injection to single animal cells using femtosecond laser-induced impulsive force, APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 93巻, 1号, pp. 39-43, 2008
  49. Chondromodulin-I and tenomodulin are differentially expressed in the avascular mesenchyme during mouse and chick development, CELL AND TISSUE RESEARCH, 332巻, 1号, pp. 111-122, 2008
  50. The anti-angiogenic factor, tenomodulin, has a pivotal role in maintaining avascularity of chordae tendineae cordis, CIRCULATION, 116巻, 16号, pp. 234-234, 2007
  51. Chondromodulin-I and tenomodulin: The negative control of angiogenesis in connective tissue, CURRENT PHARMACEUTICAL DESIGN, 13巻, 20号, pp. 2101-2112, 2007
  52. Realignment process of actin stress fibers in single living cells studied by focused femtosecond laser irradiation, APPLIED SURFACE SCIENCE, 253巻, 15号, pp. 6416-6419, 2007
  53. Immobilization of bioactive fibroblast growth factor-2 into cubic proteinous microcrystals (Bombyx mori cypovirus polyhedra) that are insoluble in a physiological cellular environment, JOURNAL OF BIOLOGICAL CHEMISTRY, 282巻, 23号, pp. 17289-17296, 2007
  54. Nondestructive micro-patterning of proteinous occlusion bodies in water by femtosecond laser-induced mechanical force, BIOMEDICAL MICRODEVICES, 9巻, 2号, pp. 105-111, 2007
  55. Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells, JOURNAL OF CELL SCIENCE, 120巻, 5号, pp. 849-857, 2007
  56. Disruption of chondromodulin-I gene, a potent angioinhibitory factor, causes aortic valve stenosis in mice, CIRCULATION, 114巻, 18号, pp. 326-326, 2006
  57. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis, NATURE MEDICINE, 12巻, 10号, pp. 1151-1159, 2006
  58. ★, Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor., J Cell Biol., 133巻, pp. 457-468, 1996
  59. Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro., Biochemical and biophysical research communications, 249巻, 3号, 1998
  60. Sequential progression of the differentiation program by bone morphogenetic protein-2 in chondrogenic cell line ATDC5., Experimental cell research, 241巻, 1号, 1998
  61. Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans., The Journal of biological chemistry, 273巻, 20号, 1998
  62. Identification of an autocrine chondrocyte colony-stimulating factor: chondromodulin-I stimulates the colony formation of growth plate chondrocytes in agarose culture., Biochemical and biophysical research communications, 241巻, 2号, 1997
  63. Identification of chondromodulin I as a novel endothelial cell growth inhibitor. Purification and its localization in the avascular zone of epiphyseal cartilage., The Journal of biological chemistry, 272巻, 51号, 1997
  64. Inhibition of DNA synthesis and tube morphogenesis of cultured vascular endothelial cells by chondromodulin-I., FEBS letters, 415巻, 3号, 1997
  65. Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 12巻, 8号, 1997
  66. Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5., Biochemical and biophysical research communications, 235巻, 1号, 1997
  67. Stimulation of osteoblast proliferation by the cartilage-derived growth promoting factors chondromodulin-I and -II., FEBS letters, 406巻, 3号, 1997
  68. [Effect of collagen on magnetization transfer contrast assessed in cultured cartilage]., Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 56巻, 12号, 1996
  69. A novel growth-promoting factor derived from fetal bovine cartilage, chondromodulin II. Purification and amino acid sequence., The Journal of biological chemistry, 271巻, 37号, 1996
  70. 1 alpha,25-dihydroxyvitamin D3 inhibits cell growth and chondrogenesis of a clonal mouse EC cell line, ATDC5., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 11巻, 1号, 1996
  71. Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor., The Journal of cell biology, 133巻, 2号, 1996
  72. Fibroblast Growth Factor 2 Enhances Tendon-to-Bone Healing in a Rat Rotator Cuff Repair of Chronic Tears., The American journal of sports medicine, 47巻, 7号, 2019
  73. Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation., Scientific reports, 9巻, 1号, 2019
  74. [Homeostasis and Disorder of Musculoskeletal System.Enthesis formation and repair:Current understanding and perspectives for the future regenerative therapy.], Clinical calcium, 28巻, 3号
  75. THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis., Journal of bone and mineral metabolism, 36巻, 4号, 2018
  76. Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells., PloS one, 12巻, 7号, 2017
  77. TGF-β1 Improves Biomechanical Strength by Extracellular Matrix Accumulation Without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model., The American journal of sports medicine, 45巻, 10号, 2017
  78. Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system., Scientific reports, 7巻, 2017
  79. Differential expression of Tenomodulin and Chondromodulin-1 at the insertion site of the tendon reflects a phenotypic transition of the resident cells., Tissue & cell, 42巻, 2号, 2010
  80. Minute pleomorphic adenoma of the submandibular gland in patients with oral malignancy: a report of two cases with histological and immunohistochemical examination., Histopathology, 51巻, 2号, 2007
  81. Immobilization of bioactive fibroblast growth factor-2 into cubic proteinous microcrystals (Bombyx mori cypovirus polyhedra) that are insoluble in a physiological cellular environment., The Journal of biological chemistry, 282巻, 23号, 2007
  82. Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells., Journal of cell science, 120巻, Pt 5号, 2007
  83. Nondestructive micro-patterning of proteinous occlusion bodies in water by femtosecond laser-induced mechanical force., Biomedical microdevices, 9巻, 2号, 2007
  84. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis., Nature medicine, 12巻, 10号, 2006
  85. Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes., Developmental biology, 298巻, 1号, 2006
  86. [Vascular development and cartilage formation]., Clinical calcium, 16巻, 4号, 2006
  87. Angiogenesis inhibitors localized in hypovascular mesenchymal tissues: chondromodulin-I and tenomodulin., Connective tissue research, 46巻, 1号, 2005
  88. Chondromodulin-I and tenomodulin: a new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues., Biochemical and biophysical research communications, 333巻, 2号, 2005
  89. [Chondromodulin-I and its related gene Tenomodulin]., Clinical calcium, 12巻, 3号, 2002
  90. [Differentiation of cartilage stem cells and their clinical applications]., Clinical calcium, 12巻, 2号, 2002
  91. Expression and localization of cartilage-specific matrix protein chondromodulin-I mRNA in salivary pleomorphic adenomas., Virchows Archiv : an international journal of pathology, 446巻, 1号, 2005
  92. Anti-angiogenic action of the C-terminal domain of tenomodulin that shares homology with chondromodulin-I., Journal of cell science, 117巻, Pt 13号, 2004
  93. Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: therapeutic potential in rheumatoid arthritis., Arthritis and rheumatism, 50巻, 3号, 2004
  94. Role of cartilage-derived anti-angiogenic factor, chondromodulin-I, during endochondral bone formation., Osteoarthritis and cartilage, 9 Suppl A巻, 2001
  95. Differentiation of chondrogenic precursor cells during the regeneration of articular cartilage., Osteoarthritis and cartilage, 9 Suppl A巻, 2001
  96. Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis., Mechanisms of development, 105巻, 1-2号, 2001
  97. Expression and localization of angiogenic inhibitory factor, chondromodulin-I, in adult rat eye., Investigative ophthalmology & visual science, 42巻, 6号, 2001
  98. Cartilage-specific matrix protein chondromodulin-I is associated with chondroid formation in salivary pleomorphic adenomas: immunohistochemical analysis., The American journal of pathology, 158巻, 4号, 2001
  99. Molecular cloning of tenomodulin, a novel chondromodulin-I related gene., Biochemical and biophysical research communications, 280巻, 5号, 2001
  100. A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells., The Journal of biological chemistry, 276巻, 14号, 2001
  101. [Angiogenic inducers and inhibitors]., Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 45巻, 13 Suppl号, 2000
  102. Differential expressions of BMP family genes during chondrogenic differentiation of mouse ATDC5 cells., Cell structure and function, 25巻, 3号, 2000
  103. Chondromodulin-I as a novel cartilage-specific growth-modulating factor., Pediatric nephrology (Berlin, Germany), 14巻, 7号, 2000
  104. A novel in vitro culture system for analysis of functional role of phosphate transport in endochondral ossification., Bone, 27巻, 1号, 2000
  105. Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 15巻, 3号, 2000
  106. Requirement of autocrine signaling by bone morphogenetic protein-4 for chondrogenic differentiation of ATDC5 cells., FEBS letters, 469巻, 1号, 2000
  107. Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo., FEBS letters, 458巻, 3号, 1999
  108. Generation of multiple transcripts from the chicken chondromodulin-I gene and their expression during embryonic development., FEBS letters, 456巻, 1号, 1999
  109. Spatiotemporal pattern of the mouse chondromodulin-I gene expression and its regulatory role in vascular invasion into cartilage during endochondral bone formation., The International journal of developmental biology, 43巻, 1号, 1999
  110. Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells., European journal of biochemistry, 260巻, 3号, 1999
  111. Molecular cloning of mouse and bovine chondromodulin-II cDNAs and the growth-promoting actions of bovine recombinant protein., Journal of biochemistry, 125巻, 3号, 1999
  112. Transcriptome analysis of early chondrogenesis in ATDC5 cells induced by bone morphogenetic protein 4., Genomics, 83巻, 1号, 2004
  113. Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes., Investigative ophthalmology & visual science, 44巻, 5号, 2003
  114. Immunohistochemical evaluation of cartilage-derived morphogenic protein-1 and -2 in normal human salivary glands and pleomorphic adenomas., Virchows Archiv : an international journal of pathology, 442巻, 5号, 2003
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  122. The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development., PloS one, 9巻, 4号, 2014
  123. Pax1 acts as a negative regulator of chondrocyte maturation., Experimental cell research, 319巻, 20号, 2013
  124. Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis., Nature genetics, 45巻, 6号, 2013
  125. Tenomodulin expression in the periodontal ligament enhances cellular adhesion., PloS one, 8巻, 4号, 2013
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招待講演、口頭・ポスター発表等

  1. Molecular mechanisms regulating tendon and ligament formation, 宿南　知佐, 第１１回 Bone Biology Forum, 2014年08月23日, 招待, 英語, 帝人ファーマ株式会社, 富士教育研究所 (静岡件裾野市)
  2. 骨格と筋肉を連結する腱の形成を支える分子メカニズム, 宿南　知佐, 第32回日本骨代謝学会学術集会, 2014年07月26日, 招待, 日本語, 島根大学医学部似化学講座　内科学第一 杉本　利嗣, 大阪

受賞

  1. 2007年, 日本結合組織学会大高賞
  2. 1995年12月, The 3rd Pan Pacific Connective Tissue Societies Symposium Young Investigator Award

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業(基盤研究(B)), 硬組織を連結する組織構築の形成メカニズム, 2014年, 2016年
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社会活動

学術会議等の主催

  1. 2015年10月, 2015年10月
  2. 第18回運動器科学研究会, 2017年09月