CHISA SHUKUNAMI

Last Updated :2022/07/01

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Professor
Web Site
E-mail
shukunamhiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2019/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Professor
  • 2013/07/23, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Professor
  • 2007/04/01, 2013/07/22, Kyoto University, Institute for Frontier Medical Sciences, Associate Professor
  • 1998/09/01, 2007/03/31, Kyoto University, Associate Professor
  • 1995/04/01, 1998/08/31, Japan Society for the Promotion of Science, JSPS Research Fellow for Young Scientists (PD)
  • 1994/04/01, 1995/03/31, Japan Society for the promotion of science, JSPS Research Fellow for Young Scientists (DC2)

Educational Backgrounds

  • Osaka University, Graduate School, Division of Dental Research, Japan, 1991/04, 1995/03
  • Hiroshima University, Faculty of Dentistry, Japan, 1985/04, 1991/03

Academic Degrees

  • DDS Ph.D, Osaka University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

In Charge of Primary Major Programs

  • Dentistry
  • Oral Health Science
  • Oral Engineering

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Functional basic dentistry
  • Biology;Biological Science;Functional biochemistry
  • Medicine,dentistry, and pharmacy;Clinical surgery;Orthopaedic surgery
  • Biology;Biological Science;Developmental biology

Research Keywords

  • tenomodulin
  • ligament
  • tendon

Affiliated Academic Societies

  • The Molecular Biology Society of Japan
  • The Japanese Society for Bone and Mineral Reserach
  • Japanese Association for Oral Biology
  • The Japanese Society for Genome Editing
  • The Japanese Society of Cartilage Metabolism
  • Japan Muscle Society
  • The Japanese Society of Matrix Biology and Medicine

Educational Activity

Course in Charge

  1. 2022, Liberal Arts Education Program1, 2Term, General Health and Oral Sciences I
  2. 2022, Undergraduate Education, 4Term, Life Science
  3. 2022, Undergraduate Education, 1Term, Oral Biochemistry I
  4. 2022, Undergraduate Education, 2Term, Oral Biochemistry II
  5. 2022, Undergraduate Education, 3Term, Practice of Oral Biochemistry
  6. 2022, Undergraduate Education, 3Term, Molecular Biology in Medicine
  7. 2022, Undergraduate Education, 4Term, Genomic Medicine
  8. 2022, Undergraduate Education, 4Term, Research Start-Up
  9. 2022, Undergraduate Education, 2Term, Topics in Dental Research II
  10. 2022, Undergraduate Education, First Semester, Dental Research Practices
  11. 2022, Undergraduate Education, Second Semester, Dental Research Practices
  12. 2022, Undergraduate Education, First Semester, Dental Research Practices
  13. 2022, Undergraduate Education, 4Term, Research Start-Up
  14. 2022, Undergraduate Education, 1Term, Basic Biochemistry
  15. 2022, Undergraduate Education, 1Term, Basic Biochemistry
  16. 2022, Undergraduate Education, 4Term, Research Start-Up
  17. 2022, Graduate Education (Master's Program) , Second Semester, Seminar
  18. 2022, Graduate Education (Doctoral Program) , 1Term, Advanced Lecture on Methods in biomedical sciences
  19. 2022, Graduate Education (Doctoral Program) , 3Term, Advanced Lecture on Creation and Development of Biomedical Sciences
  20. 2022, Graduate Education (Master's Program) , First Semester, Seminar
  21. 2022, Graduate Education (Master's Program) , First Semester, Research
  22. 2022, Graduate Education (Master's Program) , Second Semester, Research
  23. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  24. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  25. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  26. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  27. 2022, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  28. 2022, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  29. 2022, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
  30. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Dental and Medical Biochemistry
  31. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Dental and Medical Biochemistry
  32. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Dental and Medical Biochemistry
  33. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Dental and Medical Biochemistry
  34. 2022, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science
  35. 2022, Liberal Arts Education Program1, 2Term, General Health and Oral Sciences I
  36. 2022, Undergraduate Education, 4Term, Life Science
  37. 2022, Undergraduate Education, 1Term, Oral Biochemistry I
  38. 2022, Undergraduate Education, 2Term, Oral Biochemistry II
  39. 2022, Undergraduate Education, 3Term, Practice of Oral Biochemistry
  40. 2022, Undergraduate Education, 2Term, Topics in Dental Research II
  41. 2022, Undergraduate Education, 3Term, Molecular Biology in Medicine
  42. 2022, Undergraduate Education, 4Term, Genomic Medicine
  43. 2022, Undergraduate Education, 4Term, Research Start-Up
  44. 2022, Undergraduate Education, First Semester, Dental Research Practices
  45. 2022, Undergraduate Education, Second Semester, Dental Research Practices
  46. 2022, Undergraduate Education, First Semester, Dental Research Practices
  47. 2022, Undergraduate Education, 1Term, Basic Biochemistry
  48. 2022, Undergraduate Education, 4Term, Research Start-Up
  49. 2022, Undergraduate Education, 1Term, Basic Biochemistry
  50. 2022, Undergraduate Education, 4Term, Research Start-Up
  51. 2022, Graduate Education (Doctoral Program) , 1Term, Advanced Lecture on Methods in biomedical sciences
  52. 2022, Graduate Education (Doctoral Program) , 3Term, Advanced Lecture on Creation and Development of Biomedical Sciences
  53. 2022, Graduate Education (Master's Program) , First Semester, Seminar
  54. 2022, Graduate Education (Master's Program) , Second Semester, Seminar
  55. 2022, Graduate Education (Master's Program) , First Semester, Research
  56. 2022, Graduate Education (Master's Program) , Second Semester, Research
  57. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  58. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  59. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  60. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  61. 2022, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  62. 2022, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  63. 2022, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
  64. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Dental and Medical Biochemistry
  65. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Dental and Medical Biochemistry
  66. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Dental and Medical Biochemistry
  67. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Dental and Medical Biochemistry
  68. 2022, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science

Research Activities

Academic Papers

  1. ★, Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes., Sci Rep, 8, 2018
  2. Scleraxis upregulated by transforming growth factor-01 signaling inhibits tension-induced osteoblast differentiation of priodontal ligament cells via ephrin A2, BONE, 149, 202108
  3. Deficiency of TMEM53 causes a previously unknown sclerosing bone disorder by dysregulation of BMP-SMAD signaling, NATURE COMMUNICATIONS, 12(1), 20210406
  4. Role of Scx(+)/Sox9(+) cells as potential progenitor cells for postnatal supraspinatus enthesis formation and healing after injury in mice, PLOS ONE, 15(12), 20201201
  5. Transient and lineage-restricted requirement of Ebf3 for sternum ossification, DEVELOPMENT, 147(9), 202005
  6. Loss of tenomodulin expression is a risk factor for age-related intervertebral disc degeneration, AGING CELL, 19(3), 202003
  7. Frontiers of Tendon and Ligament Research "Recent progress in tendon and ligament research", Orthopaedic Surgery and Traumatology, 63(1), 83-88, 20200101
  8. Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate, CELL REPORTS, 29(3), 603-+, 20191015
  9. ★, Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation, Sci Rep., 9, 4605, 20190314
  10. ★, Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation., Scientific reports, 9(1), 2019
  11. Fibroblast Growth Factor 2 Enhances Tendon-to-Bone Healing in a Rat Rotator Cuff Repair of Chronic Tears., The American journal of sports medicine, 47(7), 2019
  12. THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis, JOURNAL OF BONE AND MINERAL METABOLISM, 36(4), 410-419, 201807
  13. Host defense against oral microbiota by bone-damaging T cells, NATURE COMMUNICATIONS, 9, 20180216
  14. TGF-beta 1 Improves Biomechanical Strength by Extracellular Matrix Accumulation Without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model, AMERICAN JOURNAL OF SPORTS MEDICINE, 45(10), 2394-2404, 201708
  15. Wnt/beta-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells, PLOS ONE, 12(7), 20170727
  16. Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load, EBIOMEDICINE, 20, 240-254, 201706
  17. ★, Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system., Scientific reports, 7, 2017
  18. TENOgenic MODULating INsider factor: systematic assessment on the functions of tenomodulin gene, GENE, 587(1), 1-17, 20160801
  19. Role of MSX1 in Osteogenic Differentiation of Human Dental Pulp Stem Cells, STEM CELLS INTERNATIONAL, 2016
  20. Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal components, JAPANESE DENTAL SCIENCE REVIEW, 52(4), 84-92, 2016
  21. ★, Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation, PLOS GENETICS, 12(1), 2016
  22. Development and integration of the musculoskeletal system, THE BONE, 29(3), 63-68, 201511
  23. A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis, AMERICAN JOURNAL OF HUMAN GENETICS, 97(2), 337-342, 20150806
  24. ★, Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone, DEVELOPMENT, 142(4), 787-796, 20150215
  25. Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells, Stem Cells and Development, 24(5), 597-609, 201501
  26. Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change, Biochem Biophys Rep., 175-189, 2015
  27. Tenomodulin, 108-109, 2015
  28. A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis., American journal of human genetics, 97(2), 2015
  29. FGF-2 Stimulates the Growth of Tenogenic Progenitor Cells to Facilitate the Generation of Tenomodulin-Positive Tenocytes in a Rat Rotator Cuff Healing Model., The American journal of sports medicine, 43(10), 2015
  30. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis., Scientific reports, 5, 2015
  31. Sox9- and Scleraxis-Cre Lineage Fate Mapping in Aortic and Mitral Valve Structures, Journal of Cardiovascular Development and Disease, 1(2), 163-176, 20140826
  32. The N- Terminal Cleavage of Chondromodulin-I in Growth- Plate Cartilage at the Hypertrophic and Calcified Zones during Bone Development, PLOS ONE, 9(4), 2014
  33. ★, Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament, Development, 140, 2280-2288, 2013
  34. Tenomodulin expression in the periodontal ligament enhances cellular adhesion., PLoS One, 8, e60203, 2013
  35. Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis., Nature genetics, 45(6), 2013
  36. Generation and characterization of ScxCre transgenic mice, GENESIS, 51(4), 275-283, 2013
  37. ★, Pax1 acts as a negative regulator of chondrocyte maturation, EXPERIMENTAL CELL RESEARCH, 319(20), 3128-3139, 2013
  38. Synthetic disulfide-bridged cyclic peptides mimic the anti-angiogenic actions of chondromodulin-I., Cancer Sci, 103, 1311-1318, 2012
  39. Conversion of Human Bone Marrow-Derived Mesenchymal Stem Cells into Tendon Progenitor Cells by Ectopic Expression of Scleraxis, STEM CELLS AND DEVELOPMENT, 21(6), 846-858, 2012
  40. ★, Direct conversion of tenocytes into chondrocytes by Sox9, EXPERIMENTAL CELL RESEARCH, 318(13), 1492-1507, 2012
  41. Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents (vol 120, pg 2292, 2010), JOURNAL OF CLINICAL INVESTIGATION, 121(1), 454-454, 2011
  42. A functional role of the glycosylated N-terminal domain of chondromodulin-I, JOURNAL OF BONE AND MINERAL METABOLISM, 29(1), 23-30, 2011
  43. Localization of chondromodulin-I at the feto-maternal interface and its inhibitory actions on trophoblast invasion in vitro, BMC CELL BIOLOGY, 12, 2011
  44. Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 42(1), 148-156, 2010
  45. Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor, EXPERIMENTAL CELL RESEARCH, 316(5), 775-788, 2010
  46. Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents, JOURNAL OF CLINICAL INVESTIGATION, 120(7), 2292-2306, 2010
  47. Differential expression of Tenomodulin and Chondromodulin-1 at the insertion site of the tendon reflects a phenotypic transition of the resident cells., Tissue & cell, 42(2), 2010
  48. ★, Differential actions of VEGF-A isoforms on perichondrial angiogenesis during endochondral bone formation, DEVELOPMENTAL BIOLOGY, 332(2), 196-211, 2009
  49. Gene delivery process in a single animal cell after femtosecond laser microinjection, APPLIED SURFACE SCIENCE, 255(24), 9880-9884, 2009
  50. Altered fracture callus formation in chondromodulin-I deficient mice., Bone, 43(6), 2008
  51. Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis., Circulation, 118(17), 2008
  52. Chondromodulin-I and tenomodulin are differentially expressed in the avascular mesenchyme during mouse and chick development, CELL AND TISSUE RESEARCH, 332(1), 111-122, 2008
  53. Nanoparticle injection to single animal cells using femtosecond laser-induced impulsive force, APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 93(1), 39-43, 2008
  54. Cartilaginous features in matrix-producing carcinoma of the breast: four cases report with histochemical and immunohistochemical analysis of matrix molecules, MODERN PATHOLOGY, 21(10), 1282-1292, 2008
  55. Local Tenomodulin Absence, Angiogenesis, and Matrix Metalloproteinase Activation Are Associated With the Rupture of the Chordae Tendineae Cordis, CIRCULATION, 118(17), 1737-1747, 2008
  56. Chordae tendineae cordis are covered and protected by the anti-angiogenic factor, Tenomodulin, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 45, S26-S26, 2008
  57. Altered fracture callus formation in chondromodulin-I deficient mice, BONE, 43(6), 1047-1056, 2008
  58. Chondromodulin-I and tenomodulin: the negative control of angiogenesis in connective tissue., Current pharmaceutical design, 13(20), 2007
  59. Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells, JOURNAL OF CELL SCIENCE, 120(5), 849-857, 2007
  60. Nondestructive micro-patterning of proteinous occlusion bodies in water by femtosecond laser-induced mechanical force, BIOMEDICAL MICRODEVICES, 9(2), 105-111, 2007
  61. Immobilization of bioactive fibroblast growth factor-2 into cubic proteinous microcrystals (Bombyx mori cypovirus polyhedra) that are insoluble in a physiological cellular environment, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(23), 17289-17296, 2007
  62. Realignment process of actin stress fibers in single living cells studied by focused femtosecond laser irradiation, APPLIED SURFACE SCIENCE, 253(15), 6416-6419, 2007
  63. Chondromodulin-I and tenomodulin: The negative control of angiogenesis in connective tissue, CURRENT PHARMACEUTICAL DESIGN, 13(20), 2101-2112, 2007
  64. The anti-angiogenic factor, tenomodulin, has a pivotal role in maintaining avascularity of chordae tendineae cordis, CIRCULATION, 116(16), 234-234, 2007
  65. Immobilization of bioactive fibroblast growth factor-2 into cubic proteinous microcrystals (Bombyx mori cypovirus polyhedra) that are insoluble in a physiological cellular environment., The Journal of biological chemistry, 282(23), 2007
  66. Minute pleomorphic adenoma of the submandibular gland in patients with oral malignancy: a report of two cases with histological and immunohistochemical examination., Histopathology, 51(2), 2007
  67. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis, NATURE MEDICINE, 12(10), 1151-1159, 2006
  68. Disruption of chondromodulin-I gene, a potent angioinhibitory factor, causes aortic valve stenosis in mice, CIRCULATION, 114(18), 326-326, 2006
  69. [Vascular development and cartilage formation]., Clinical calcium, 16(4), 2006
  70. ★, Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes., Developmental biology, 298(1), 2006
  71. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis., Nature medicine, 12(10), 2006
  72. Expression and localization of cartilage-specific matrix protein chondromodulin-I mRNA in salivary pleomorphic adenomas., Virchows Archiv : an international journal of pathology, 446(1), 2005
  73. Chondromodulin-I and tenomodulin: a new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues., Biochemical and biophysical research communications, 333(2), 2005
  74. Angiogenesis inhibitors localized in hypovascular mesenchymal tissues: chondromodulin-I and tenomodulin., Connective tissue research, 46(1), 2005
  75. Transcriptome analysis of early chondrogenesis in ATDC5 cells induced by bone morphogenetic protein 4., Genomics, 83(1), 2004
  76. Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: therapeutic potential in rheumatoid arthritis., Arthritis and rheumatism, 50(3), 2004
  77. Anti-angiogenic action of the C-terminal domain of tenomodulin that shares homology with chondromodulin-I., Journal of cell science, 117(Pt 13), 2004
  78. Chondromodulin I is a bone remodeling factor., Molecular and cellular biology, 23(2), 2003
  79. Immunohistochemical evaluation of cartilage-derived morphogenic protein-1 and -2 in normal human salivary glands and pleomorphic adenomas., Virchows Archiv : an international journal of pathology, 442(5), 2003
  80. Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes., Investigative ophthalmology & visual science, 44(5), 2003
  81. Cartilage-specific matrix protein, chondromodulin-I (ChM-I), is a strong angio-inhibitor in endochondral ossification of human neonatal vertebral tissues in vivo: relationship with angiogenic factors in the cartilage., Acta histochemica, 104(2), 2002
  82. [Differentiation of cartilage stem cells and their clinical applications]., Clinical calcium, 12(2), 2002
  83. [Chondromodulin-I and its related gene Tenomodulin]., Clinical calcium, 12(3), 2002
  84. A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells., The Journal of biological chemistry, 276(14), 2001
  85. Molecular cloning of tenomodulin, a novel chondromodulin-I related gene., Biochemical and biophysical research communications, 280(5), 2001
  86. Cartilage-specific matrix protein chondromodulin-I is associated with chondroid formation in salivary pleomorphic adenomas: immunohistochemical analysis., The American journal of pathology, 158(4), 2001
  87. Expression and localization of angiogenic inhibitory factor, chondromodulin-I, in adult rat eye., Investigative ophthalmology & visual science, 42(6), 2001
  88. Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis., Mechanisms of development, 105(1-2), 2001
  89. Differentiation of chondrogenic precursor cells during the regeneration of articular cartilage., Osteoarthritis and cartilage, 9 Suppl A, 2001
  90. Role of cartilage-derived anti-angiogenic factor, chondromodulin-I, during endochondral bone formation., Osteoarthritis and cartilage, 9 Suppl A, 2001
  91. Requirement of autocrine signaling by bone morphogenetic protein-4 for chondrogenic differentiation of ATDC5 cells., FEBS letters, 469(1), 2000
  92. Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 15(3), 2000
  93. A novel in vitro culture system for analysis of functional role of phosphate transport in endochondral ossification., Bone, 27(1), 2000
  94. Chondromodulin-I as a novel cartilage-specific growth-modulating factor., Pediatric nephrology (Berlin, Germany), 14(7), 2000
  95. Differential expressions of BMP family genes during chondrogenic differentiation of mouse ATDC5 cells., Cell structure and function, 25(3), 2000
  96. [Angiogenic inducers and inhibitors]., Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 45(13 Suppl), 2000
  97. Molecular cloning of mouse and bovine chondromodulin-II cDNAs and the growth-promoting actions of bovine recombinant protein., Journal of biochemistry, 125(3), 1999
  98. Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells., European journal of biochemistry, 260(3), 1999
  99. Spatiotemporal pattern of the mouse chondromodulin-I gene expression and its regulatory role in vascular invasion into cartilage during endochondral bone formation., The International journal of developmental biology, 43(1), 1999
  100. Generation of multiple transcripts from the chicken chondromodulin-I gene and their expression during embryonic development., FEBS letters, 456(1), 1999
  101. Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo., FEBS letters, 458(3), 1999
  102. Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans., The Journal of biological chemistry, 273(20), 1998
  103. Sequential progression of the differentiation program by bone morphogenetic protein-2 in chondrogenic cell line ATDC5., Experimental cell research, 241(1), 1998
  104. Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro., Biochemical and biophysical research communications, 249(3), 1998
  105. Stimulation of osteoblast proliferation by the cartilage-derived growth promoting factors chondromodulin-I and -II., FEBS letters, 406(3), 1997
  106. Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5., Biochemical and biophysical research communications, 235(1), 1997
  107. ★, Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 12(8), 1997
  108. Inhibition of DNA synthesis and tube morphogenesis of cultured vascular endothelial cells by chondromodulin-I., FEBS letters, 415(3), 1997
  109. Identification of chondromodulin I as a novel endothelial cell growth inhibitor. Purification and its localization in the avascular zone of epiphyseal cartilage., The Journal of biological chemistry, 272(51), 1997
  110. Identification of an autocrine chondrocyte colony-stimulating factor: chondromodulin-I stimulates the colony formation of growth plate chondrocytes in agarose culture., Biochemical and biophysical research communications, 241(2), 1997
  111. ★, Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor., J Cell Biol., 133, 457-468, 1996
  112. ★, Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor., The Journal of cell biology, 133(2), 1996
  113. 1 alpha,25-dihydroxyvitamin D3 inhibits cell growth and chondrogenesis of a clonal mouse EC cell line, ATDC5., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 11(1), 1996
  114. A novel growth-promoting factor derived from fetal bovine cartilage, chondromodulin II. Purification and amino acid sequence., The Journal of biological chemistry, 271(37), 1996
  115. [Effect of collagen on magnetization transfer contrast assessed in cultured cartilage]., Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 56(12), 1996
  116. [Integration of the musculoskeletal components by tendons and ligaments.], Clinical calcium, 27(3)
  117. [Homeostasis and Disorder of Musculoskeletal System.Enthesis formation and repair:Current understanding and perspectives for the future regenerative therapy.], Clinical calcium, 28(3)

Awards

  1. 1995/12, The 3rd Pan Pacific Connective Tissue Societies Symposium Young Investigator Award

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2014, 2016
  2. KAKENHI, 2013, 2014
  3. KAKENHI, 2012, 2014
  4. KAKENHI, Establishment of genetically modified mice for the analysis of tendon/ligament formation and regeneration, 2011, 2012
  5. KAKENHI, Identification of transcription factors that regulate tendon/ligament formation, 2010, 2012
  6. KAKENHI, Molecular analysis of tendon and ligament formation, 2007, 2008
  7. KAKENHI, Molecular basis of anti-angiogenic barriers in mesenchymal tissues, 2005, 2009
  8. KAKENHI, Identification and functional analysis of genes that regulate chondrogenic differentiation during endochonral bone formation, 2004, 2006
  9. KAKENHI, Functional analysis by generation of mice lacking ChMrP, a novel angiogenesis inhibitor, 2001, 2002
  10. KAKENHI, 2000, 2004
  11. KAKENHI, 1999, 1999
  12. KAKENHI, 2013, 2016
  13. 2014/04/01, 2015/03/31
  14. KAKENHI, 2016, 2017
  15. Practical Research Project for Rare / Intractable Diseases , 2017/04/01, 2018/03/31
  16. 2017/04/01, 2018/03/31
  17. KAKENHI, 2017/04/01, 2018/03/31
  18. KAKENHI, 2017/04/01, 2018/03/31
  19. Practical Research Project for Rare / Intractable Diseases , 2018/04/01, 2019/03/31
  20. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2018, 2020
  21. Practical Research Project for Rare / Intractable Diseases , 2019/04/01, 2020/03/31

Social Activities

Organizing Academic Conferences, etc.

  1. 2017/09