CHISA SHUKUNAMI

Last Updated :2021/03/01

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Professor
Web Site
E-mail
shukunamhiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 1998/09/01, 2007/03/31, Kyoto University, Associate Professor
  • 2013/07/23, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Professor
  • 2007/04/01, 2013/07/22, KyotoUniversity, Institute for Frontier Medical Sciences, Associate Professor

Educational Backgrounds

  • Osaka University, Graduate School, Division of Dental Research, Japan, 1991/04, 1995/03
  • Hiroshima University, Faculty of Dentistry, Japan, 1985/04, 1991/03

Academic Degrees

  • DDS Ph.D, Osaka University

Educational Activity

  • 【Bachelor Degree Program】School of Dentistry : Program of Dentistry

In Charge of Primary Major Programs

  • Dentistry
  • Oral Health Science
  • Oral Engineering

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Functional basic dentistry
  • Biology;Biological Science;Functional biochemistry
  • Medicine,dentistry, and pharmacy;Clinical surgery;Orthopaedic surgery
  • Biology;Biological Science;Developmental biology

Research Keywords

  • tenomodulin
  • ligament
  • tendon

Affiliated Academic Societies

  • The Japanese Society for Bone and Mineral Reserach

Educational Activity

Course in Charge

  1. 2020, Liberal Arts Education Program1, 2Term, General Health and Oral Sciences I
  2. 2020, Undergraduate Education, 4Term, Life Science
  3. 2020, Undergraduate Education, 1Term, Oral biochemistry
  4. 2020, Undergraduate Education, 2Term, Oral biochemistry
  5. 2020, Undergraduate Education, 3Term, Practice of Oral Biochemistry
  6. 2020, Undergraduate Education, 3Term, Molecular Biology in Medicine
  7. 2020, Undergraduate Education, 4Term, Genomic Medicine
  8. 2020, Undergraduate Education, 4Term, Research Start-Up
  9. 2020, Undergraduate Education, 2Term, Topics in Denral Research
  10. 2020, Undergraduate Education, First Semester, Laboratory of Oral Function Sciences-Biochemistry,Physiology,Pharmacology-
  11. 2020, Undergraduate Education, First Semester, Dental Research Practices
  12. 2020, Undergraduate Education, Second Semester, Dental Research Practices
  13. 2020, Undergraduate Education, 1Term, Basic Biochemistry
  14. 2020, Undergraduate Education, 4Term, Research Start-Up
  15. 2020, Undergraduate Education, 1Term, Basic Biochemistry
  16. 2020, Undergraduate Education, 4Term, Research Start-Up
  17. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  18. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  19. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  20. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Methods in biomedical sciences
  21. 2020, Graduate Education (Master's Program) , First Semester, Research
  22. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Dental and Medical Biochemistry
  23. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Dental and Medical Biochemistry
  24. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced research on Dental and Medical Biochemistry
  25. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Dental and Medical Biochemistry
  26. 2020, Graduate Education (Master's Program) , First Semester, Seminar
  27. 2020, Graduate Education (Master's Program) , Second Semester, Seminar
  28. 2020, Graduate Education (Master's Program) , Second Semester, Research
  29. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  30. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  31. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  32. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  33. 2020, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  34. 2020, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  35. 2020, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
  36. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Dental and Medical Biochemistry
  37. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Dental and Medical Biochemistry
  38. 2020, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Dental and Medical Biochemistry
  39. 2020, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Dental and Medical Biochemistry
  40. 2020, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science

Research Activities

Academic Papers

  1. Transient and lineage-restricted requirement of Ebf3 for sternum ossification, DEVELOPMENT, 147(9), 202005
  2. Loss of tenomodulin expression is a risk factor for age-related intervertebral disc degeneration, AGING CELL, 19(3), 202003
  3. ★, Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation, Sci Rep., 9, 4605, 20190314
  4. Fibroblast Growth Factor 2 Enhances Tendon-to-Bone Healing in a Rat Rotator Cuff Repair of Chronic Tears, AMERICAN JOURNAL OF SPORTS MEDICINE, 47(7), 1701-1712, 2019
  5. Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate, CELL REPORTS, 29(3), 603-+, 20191015
  6. THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis, JOURNAL OF BONE AND MINERAL METABOLISM, 36(4), 410-419, 201807
  7. Host defense against oral microbiota by bone-damaging T cells, NATURE COMMUNICATIONS, 9, 20180216
  8. Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes, SCIENTIFIC REPORTS, 8, 20180216
  9. TGF-beta 1 Improves Biomechanical Strength by Extracellular Matrix Accumulation Without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model, AMERICAN JOURNAL OF SPORTS MEDICINE, 45(10), 2394-2404, 201708
  10. Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load, EBIOMEDICINE, 20, 240-254, 201706
  11. Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system, SCIENTIFIC REPORTS, 7, 20170322
  12. Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation, PLOS GENETICS, 12(1), 2016
  13. Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal components, JAPANESE DENTAL SCIENCE REVIEW, 52(4), 84-92, 2016
  14. Role of MSX1 in Osteogenic Differentiation of Human Dental Pulp Stem Cells, STEM CELLS INTERNATIONAL, 2016
  15. TENOgenic MODULating INsider factor: systematic assessment on the functions of tenomodulin gene, GENE, 587(1), 1-17, 20160801
  16. Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone, DEVELOPMENT, 142(4), 787-796, 2015
  17. Tenomodulin, 108-109, 2015
  18. Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells, Stem Cells and Development, 24(5), 597-609, 201501
  19. Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change, Biochem Biophys Rep., 175-189, 2015
  20. A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis, AMERICAN JOURNAL OF HUMAN GENETICS, 97(2), 337-342, 20150806
  21. ★, Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone, DEVELOPMENT, 142(4), 787-796, 20150215
  22. The N- Terminal Cleavage of Chondromodulin-I in Growth- Plate Cartilage at the Hypertrophic and Calcified Zones during Bone Development, PLOS ONE, 9(4), 2014
  23. Sox9- and Scleraxis-Cre Lineage Fate Mapping in Aortic and Mitral Valve Structures, Journal of Cardiovascular Development and Disease, 1(2), 163-176, 20140826
  24. Pax1 acts as a negative regulator of chondrocyte maturation, EXPERIMENTAL CELL RESEARCH, 319(20), 3128-3139, 2013
  25. Generation and characterization of ScxCre transgenic mice, GENESIS, 51(4), 275-283, 2013
  26. Tenomodulin expression in the periodontal ligament enhances cellular adhesion., PLoS One, 8, e60203, 2013
  27. ★, Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament, DEVELOPMENT, 140(11), 2280-2288, 2013
  28. Direct conversion of tenocytes into chondrocytes by Sox9, EXPERIMENTAL CELL RESEARCH, 318(13), 1492-1507, 2012
  29. Conversion of Human Bone Marrow-Derived Mesenchymal Stem Cells into Tendon Progenitor Cells by Ectopic Expression of Scleraxis, STEM CELLS AND DEVELOPMENT, 21(6), 846-858, 2012
  30. Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis., Stem Cells Dev, 21, 846-858, 2012
  31. Synthetic disulfide-bridged cyclic peptides mimic the anti-angiogenic actions of chondromodulin-I., Cancer Sci, 103, 1311-1318, 2012
  32. Localization of chondromodulin-I at the feto-maternal interface and its inhibitory actions on trophoblast invasion in vitro, BMC CELL BIOLOGY, 12, 2011
  33. A functional role of the glycosylated N-terminal domain of chondromodulin-I, JOURNAL OF BONE AND MINERAL METABOLISM, 29(1), 23-30, 2011
  34. Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents (vol 120, pg 2292, 2010), JOURNAL OF CLINICAL INVESTIGATION, 121(1), 454-454, 2011
  35. Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents, JOURNAL OF CLINICAL INVESTIGATION, 120(7), 2292-2306, 2010
  36. Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor, EXPERIMENTAL CELL RESEARCH, 316(5), 775-788, 2010
  37. Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 42(1), 148-156, 2010
  38. Gene delivery process in a single animal cell after femtosecond laser microinjection, APPLIED SURFACE SCIENCE, 255(24), 9880-9884, 2009
  39. Differential actions of VEGF-A isoforms on perichondrial angiogenesis during endochondral bone formation, DEVELOPMENTAL BIOLOGY, 332(2), 196-211, 2009
  40. Altered fracture callus formation in chondromodulin-I deficient mice, BONE, 43(6), 1047-1056, 2008
  41. Chordae tendineae cordis are covered and protected by the anti-angiogenic factor, Tenomodulin, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 45, S26-S26, 2008
  42. Local Tenomodulin Absence, Angiogenesis, and Matrix Metalloproteinase Activation Are Associated With the Rupture of the Chordae Tendineae Cordis, CIRCULATION, 118(17), 1737-1747, 2008
  43. Cartilaginous features in matrix-producing carcinoma of the breast: four cases report with histochemical and immunohistochemical analysis of matrix molecules, MODERN PATHOLOGY, 21(10), 1282-1292, 2008
  44. Nanoparticle injection to single animal cells using femtosecond laser-induced impulsive force, APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 93(1), 39-43, 2008
  45. Chondromodulin-I and tenomodulin are differentially expressed in the avascular mesenchyme during mouse and chick development, CELL AND TISSUE RESEARCH, 332(1), 111-122, 2008
  46. The anti-angiogenic factor, tenomodulin, has a pivotal role in maintaining avascularity of chordae tendineae cordis, CIRCULATION, 116(16), 234-234, 2007
  47. Chondromodulin-I and tenomodulin: The negative control of angiogenesis in connective tissue, CURRENT PHARMACEUTICAL DESIGN, 13(20), 2101-2112, 2007
  48. Realignment process of actin stress fibers in single living cells studied by focused femtosecond laser irradiation, APPLIED SURFACE SCIENCE, 253(15), 6416-6419, 2007
  49. Immobilization of bioactive fibroblast growth factor-2 into cubic proteinous microcrystals (Bombyx mori cypovirus polyhedra) that are insoluble in a physiological cellular environment, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(23), 17289-17296, 2007
  50. Nondestructive micro-patterning of proteinous occlusion bodies in water by femtosecond laser-induced mechanical force, BIOMEDICAL MICRODEVICES, 9(2), 105-111, 2007
  51. Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells, JOURNAL OF CELL SCIENCE, 120(5), 849-857, 2007
  52. Disruption of chondromodulin-I gene, a potent angioinhibitory factor, causes aortic valve stenosis in mice, CIRCULATION, 114(18), 326-326, 2006
  53. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis, NATURE MEDICINE, 12(10), 1151-1159, 2006
  54. ★, Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor., J Cell Biol., 133, 457-468, 1996
  55. Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro., Biochemical and biophysical research communications, 249(3), 1998
  56. Sequential progression of the differentiation program by bone morphogenetic protein-2 in chondrogenic cell line ATDC5., Experimental cell research, 241(1), 1998
  57. Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans., The Journal of biological chemistry, 273(20), 1998
  58. Identification of an autocrine chondrocyte colony-stimulating factor: chondromodulin-I stimulates the colony formation of growth plate chondrocytes in agarose culture., Biochemical and biophysical research communications, 241(2), 1997
  59. Identification of chondromodulin I as a novel endothelial cell growth inhibitor. Purification and its localization in the avascular zone of epiphyseal cartilage., The Journal of biological chemistry, 272(51), 1997
  60. Inhibition of DNA synthesis and tube morphogenesis of cultured vascular endothelial cells by chondromodulin-I., FEBS letters, 415(3), 1997
  61. Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 12(8), 1997
  62. Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5., Biochemical and biophysical research communications, 235(1), 1997
  63. Stimulation of osteoblast proliferation by the cartilage-derived growth promoting factors chondromodulin-I and -II., FEBS letters, 406(3), 1997
  64. [Effect of collagen on magnetization transfer contrast assessed in cultured cartilage]., Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 56(12), 1996
  65. A novel growth-promoting factor derived from fetal bovine cartilage, chondromodulin II. Purification and amino acid sequence., The Journal of biological chemistry, 271(37), 1996
  66. 1 alpha,25-dihydroxyvitamin D3 inhibits cell growth and chondrogenesis of a clonal mouse EC cell line, ATDC5., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 11(1), 1996
  67. Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor., The Journal of cell biology, 133(2), 1996
  68. Fibroblast Growth Factor 2 Enhances Tendon-to-Bone Healing in a Rat Rotator Cuff Repair of Chronic Tears., The American journal of sports medicine, 47(7), 2019
  69. Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation., Scientific reports, 9(1), 2019
  70. [Homeostasis and Disorder of Musculoskeletal System.Enthesis formation and repair:Current understanding and perspectives for the future regenerative therapy.], Clinical calcium, 28(3)
  71. THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis., Journal of bone and mineral metabolism, 36(4), 2018
  72. Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells., PloS one, 12(7), 2017
  73. TGF-β1 Improves Biomechanical Strength by Extracellular Matrix Accumulation Without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model., The American journal of sports medicine, 45(10), 2017
  74. Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system., Scientific reports, 7, 2017
  75. Differential expression of Tenomodulin and Chondromodulin-1 at the insertion site of the tendon reflects a phenotypic transition of the resident cells., Tissue & cell, 42(2), 2010
  76. Minute pleomorphic adenoma of the submandibular gland in patients with oral malignancy: a report of two cases with histological and immunohistochemical examination., Histopathology, 51(2), 2007
  77. Immobilization of bioactive fibroblast growth factor-2 into cubic proteinous microcrystals (Bombyx mori cypovirus polyhedra) that are insoluble in a physiological cellular environment., The Journal of biological chemistry, 282(23), 2007
  78. Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells., Journal of cell science, 120(Pt 5), 2007
  79. Nondestructive micro-patterning of proteinous occlusion bodies in water by femtosecond laser-induced mechanical force., Biomedical microdevices, 9(2), 2007
  80. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis., Nature medicine, 12(10), 2006
  81. Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes., Developmental biology, 298(1), 2006
  82. [Vascular development and cartilage formation]., Clinical calcium, 16(4), 2006
  83. Angiogenesis inhibitors localized in hypovascular mesenchymal tissues: chondromodulin-I and tenomodulin., Connective tissue research, 46(1), 2005
  84. Chondromodulin-I and tenomodulin: a new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues., Biochemical and biophysical research communications, 333(2), 2005
  85. [Chondromodulin-I and its related gene Tenomodulin]., Clinical calcium, 12(3), 2002
  86. [Differentiation of cartilage stem cells and their clinical applications]., Clinical calcium, 12(2), 2002
  87. Expression and localization of cartilage-specific matrix protein chondromodulin-I mRNA in salivary pleomorphic adenomas., Virchows Archiv : an international journal of pathology, 446(1), 2005
  88. Anti-angiogenic action of the C-terminal domain of tenomodulin that shares homology with chondromodulin-I., Journal of cell science, 117(Pt 13), 2004
  89. Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: therapeutic potential in rheumatoid arthritis., Arthritis and rheumatism, 50(3), 2004
  90. Role of cartilage-derived anti-angiogenic factor, chondromodulin-I, during endochondral bone formation., Osteoarthritis and cartilage, 9 Suppl A, 2001
  91. Differentiation of chondrogenic precursor cells during the regeneration of articular cartilage., Osteoarthritis and cartilage, 9 Suppl A, 2001
  92. Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis., Mechanisms of development, 105(1-2), 2001
  93. Expression and localization of angiogenic inhibitory factor, chondromodulin-I, in adult rat eye., Investigative ophthalmology & visual science, 42(6), 2001
  94. Cartilage-specific matrix protein chondromodulin-I is associated with chondroid formation in salivary pleomorphic adenomas: immunohistochemical analysis., The American journal of pathology, 158(4), 2001
  95. Molecular cloning of tenomodulin, a novel chondromodulin-I related gene., Biochemical and biophysical research communications, 280(5), 2001
  96. A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells., The Journal of biological chemistry, 276(14), 2001
  97. [Angiogenic inducers and inhibitors]., Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 45(13 Suppl), 2000
  98. Differential expressions of BMP family genes during chondrogenic differentiation of mouse ATDC5 cells., Cell structure and function, 25(3), 2000
  99. Chondromodulin-I as a novel cartilage-specific growth-modulating factor., Pediatric nephrology (Berlin, Germany), 14(7), 2000
  100. A novel in vitro culture system for analysis of functional role of phosphate transport in endochondral ossification., Bone, 27(1), 2000
  101. Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells., Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 15(3), 2000
  102. Requirement of autocrine signaling by bone morphogenetic protein-4 for chondrogenic differentiation of ATDC5 cells., FEBS letters, 469(1), 2000
  103. Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo., FEBS letters, 458(3), 1999
  104. Generation of multiple transcripts from the chicken chondromodulin-I gene and their expression during embryonic development., FEBS letters, 456(1), 1999
  105. Spatiotemporal pattern of the mouse chondromodulin-I gene expression and its regulatory role in vascular invasion into cartilage during endochondral bone formation., The International journal of developmental biology, 43(1), 1999
  106. Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells., European journal of biochemistry, 260(3), 1999
  107. Molecular cloning of mouse and bovine chondromodulin-II cDNAs and the growth-promoting actions of bovine recombinant protein., Journal of biochemistry, 125(3), 1999
  108. Transcriptome analysis of early chondrogenesis in ATDC5 cells induced by bone morphogenetic protein 4., Genomics, 83(1), 2004
  109. Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes., Investigative ophthalmology & visual science, 44(5), 2003
  110. Immunohistochemical evaluation of cartilage-derived morphogenic protein-1 and -2 in normal human salivary glands and pleomorphic adenomas., Virchows Archiv : an international journal of pathology, 442(5), 2003
  111. Chondromodulin I is a bone remodeling factor., Molecular and cellular biology, 23(2), 2003
  112. Cartilage-specific matrix protein, chondromodulin-I (ChM-I), is a strong angio-inhibitor in endochondral ossification of human neonatal vertebral tissues in vivo: relationship with angiogenic factors in the cartilage., Acta histochemica, 104(2), 2002
  113. [Integration of the musculoskeletal components by tendons and ligaments.], Clinical calcium, 27(3)
  114. Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation., PLoS genetics, 12(1), 2016
  115. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis., Scientific reports, 5, 2015
  116. FGF-2 Stimulates the Growth of Tenogenic Progenitor Cells to Facilitate the Generation of Tenomodulin-Positive Tenocytes in a Rat Rotator Cuff Healing Model., The American journal of sports medicine, 43(10), 2015
  117. A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis., American journal of human genetics, 97(2), 2015
  118. The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development., PloS one, 9(4), 2014
  119. Pax1 acts as a negative regulator of chondrocyte maturation., Experimental cell research, 319(20), 2013
  120. Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis., Nature genetics, 45(6), 2013
  121. Tenomodulin expression in the periodontal ligament enhances cellular adhesion., PloS one, 8(4), 2013
  122. Generation and characterization of ScxCre transgenic mice., Genesis (New York, N.Y. : 2000), 51(4), 2013
  123. Localization of chondromodulin-I at the feto-maternal interface and its inhibitory actions on trophoblast invasion in vitro., BMC cell biology, 12, 2011
  124. Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents., The Journal of clinical investigation, 120(7), 2010
  125. A functional role of the glycosylated N-terminal domain of chondromodulin-I., Journal of bone and mineral metabolism, 29(1), 2011
  126. Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor., Experimental cell research, 316(5), 2010
  127. Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription., The international journal of biochemistry & cell biology, 42(1), 2010
  128. Differential actions of VEGF-A isoforms on perichondrial angiogenesis during endochondral bone formation., Developmental biology, 332(2), 2009
  129. Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis., Circulation, 118(17), 2008
  130. Altered fracture callus formation in chondromodulin-I deficient mice., Bone, 43(6), 2008
  131. Cartilaginous features in matrix-producing carcinoma of the breast: four cases report with histochemical and immunohistochemical analysis of matrix molecules., Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(10), 2008
  132. Chondromodulin-I and tenomodulin are differentially expressed in the avascular mesenchyme during mouse and chick development., Cell and tissue research, 332(1), 2008
  133. Chondromodulin-I and tenomodulin: the negative control of angiogenesis in connective tissue., Current pharmaceutical design, 13(20), 2007
  134. ★, Direct conversion of tenocytes into chondrocytes by Sox9., Exp Cell Res, 318, 1492-1507, 2012

Awards

  1. 1995/12, The 3rd Pan Pacific Connective Tissue Societies Symposium Young Investigator Award

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2014, 2016

Social Activities

Organizing Academic Conferences, etc.

  1. 2017/09