茂久田 翔SHO MOKUDA

Last Updated :2022/12/01

所属・職名
広島大学病院
メールアドレス
sho-mokudahiroshima-u.ac.jp

基本情報

主な職歴

  • 2015年10月27日, 2018年08月17日, スクリプス研究所, Deparment of Molecular and Experimental Medicine, Research Associate
  • 2009年08月01日, 2013年03月31日, 道後温泉病院, リウマチセンター, 内科医師
  • 2006年04月01日, 2009年07月31日, 国家公務員共済組合連合会 虎の門病院, 内科, 研修医

学位

  • 博士(医学) (広島大学)

担当主専攻プログラム

  • 医学プログラム

研究分野

  • 医歯薬学 / 内科系臨床医学 / 膠原病・アレルギー内科学

研究キーワード

  • リウマチ学

所属学会

  • 日本リウマチ学会
  • 日本臨床検査医学会
  • 日本内科学会
  • 日本臨床免疫学会
  • 日本炎症・再生医学会

教育活動

授業担当

  1. 2022年, 学部専門, 通年, 器官・システム病態制御学II

研究活動

学術論文(★は代表的な論文)

  1. C-reactive protein and ground-glass opacity as predictors for intractable interstitial lung disease in patients with systemic sclerosis under cyclophosphamide treatment regardless of concomitant glucocorticoids, MODERN RHEUMATOLOGY, 32巻, 1号, pp. 141-148, 20220105
  2. The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient, INTERNAL MEDICINE, 61巻, 11号, pp. 1785-1788, 2022
  3. N1- methylpseudouridine -incorporated mRNA enhances exogenous protein expression and suppresses immunogenicity in primary human fibroblast-like synoviocytes, Cytotechnology, 74巻, pp. 503-514, 2022
  4. Anti-spike protein antibody responses to BNT162b2 mRNA vaccine: A single-center survey in a COVID-19 non-epidemic area in Japan, Vaccine: X, 11巻, pp. 100173., 2022
  5. The Lipopolysaccharide Mutant Re-LPS Is a Useful Tool for Detecting LPS Contamination in Rheumatoid Synovial Cell Cultures, Pathobiology, 89巻, 2号, pp. 92-100, 2022
  6. Comment on: Combination of immunosuppressive therapy and nintedanib improves capillaroscopic changes in systemic sclerosis-interstitial lung disease: a case report, Rheumatology Advances in Practice, 6巻, 1号, pp. rkac024., 2022
  7. Comment on: Nailfold capillaries and myositis-specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive DM. Reply, Rheumatology (Oxford), 61巻, 5号, pp. e122-e124, 2022
  8. The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient, Internal Medicine, 61巻, 11号, pp. 1785-1788, 2022
  9. The clinical characteristics and predictors of severe digital ischemia in patients with anti-aminoacyl transfer RNA synthetase antibodies, The Journal of Dermatology, 48巻, 7号, pp. 1044-1051, 2021
  10. C-reactive protein and ground-glass opacity as predictors for intractable interstitial lung disease in patients with systemic sclerosis under cyclophosphamide treatment regardless of concomitant glucocorticoids, Modern Rheumatology, 32巻, 1号, pp. 141-148, 2022
  11. Tapering and discontinuation of oral glucocorticoids without deterioration of disease status in patients with rheumatoid arthritis under a stable treatment, Modern Rheumatology, 31巻, 4号, pp. 803-808, 2021
  12. Lower CH50 as a predictor for intractable or recurrent lupus enteritis: A retrospective observational study, Modern Rheumatology, 31巻, 3号, pp. 643-648, 2021
  13. Activin A Expressed in Rheumatoid Synovial Cells Downregulates TNFalpha-Induced CXCL10 Expression and Osteoclastogenesis, Pathobiology, 87巻, 3号, pp. 198-207, 2020
  14. Serum CXCL10 levels are associated with better responses to abatacept treatment of rheumatoid arthritis, Clinical and Experimental Rheumatology, 38巻, 5号, pp. 956-963, 2020
  15. Evaluation of 48-week daily teriparatide treatment with DXA-based hip structure analysis in elderly female patients with rheumatoid arthritis, Medical Research Archives, 3巻, pp. 3, 20150430
  16. Asymptomatic coronary aneurysms in a patient with eosinophilic granulomatosis with polyangiitis who developed a digital gangrene, Modern Rheumatology Case Reports, 5巻, 1号, pp. 130-136, 2021
  17. Immunoglobulin D-kappa multiple myeloma in a patient with rheumatoid arthritis: a case report and review of the literature, Modern Rheumatology Case Reports, 5巻, 1号, pp. 22-28, 2021
  18. Successful hydroxychloroquine treatment in a patient with systemic lupus erythematosus-associated nailfold capillary abnormalities, Rheumatology Advances in Practice, 4巻, 2号, pp. rkaa060, 20201105
  19. Nailfold capillaries and myositis-specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis, RHEUMATOLOGY (Oxford), 61巻, 5号, pp. 2006-2015, 20220505
  20. Rapid changes of nailfold capillary abnormalities during treatment for a patient with dermatomyositis complicated by lung cancer: a case report., Modern Rheumatology Case Reports, 5巻, pp. 95-100, 2021
  21. Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s., Scientific Reports, 11巻, pp. 13109, 2021
  22. Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2alpha expression and coordinately regulate cartilage homeostasis., Nature Communications, 12巻, pp. 4148, 2021
  23. ★, Angiotensin-converting enzyme 2, a SARS-CoV-2 receptor, is upregulated by interleukin-6 through STAT3 signaling in synovial tissues, The Journal of Rheumatology, pp. jrheum.200547-jrheum.200547, 20200701
  24. TGFbeta1 Regulates Human RANKL-Induced Osteoclastogenesis via Suppression of NFATc1 Expression, International Journal of Molecular Sciences, 21巻, pp. 800, 2020
  25. Successful hydroxychloroquine treatment in a patient with SLE-associated nailfold capillary abnormalities., Rheumatology Advances in Practice, 4巻, pp. rka060, 2020
  26. Methotrexate-associated reversible liver atrophy in a patient with rheumatoid arthritis, Rheumatology Advances in Practice, 4巻, pp. rkaa014, 2020
  27. Large-vessel vasculitis associated with PEGylated granulocyte-colony stimulating factor, NETHERLANDS JOURNAL OF MEDICINE, 77巻, 6号, pp. 224-226, 201907
  28. Tumour necrosis factor alpha augments the inhibitory effects of CTLA-4-Ig on osteoclast generation from human monocytes via induction of CD80 expression, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 196巻, 3号, pp. 392-402, 201906
  29. ★, Wwp2 maintains cartilage homeostasis through regulation of Adamts5., Nature communications, 10巻, 1号, pp. 2429, 201906
  30. FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration., Aging cell, 17巻, 5号, pp. e12800-e12800, 201807
  31. ★, Dissecting the roles of miR-140 and its host gene, Nature Cell Biology, 20巻, 5号, pp. 516-518, 20180501
  32. FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis., Science translational medicine, 10巻, 428号, 201802
  33. The prevalence of endoscopic gastric mucosal damage in patients with rheumatoid arthritis., PLoS one, 13巻, 7号, pp. e0200023, 2018
  34. Bisulfite sequencing for DNA methylation analysis of primary muscle stem cells, Methods in Molecular Biology, 1668巻, pp. 3-13, 2017
  35. Neurological Complications in Eosinophilic Granulomatosis with Polyangiitis (EGPA): The Roles of History and Physical Examinations in the Diagnosis of EGPA, INTERNAL MEDICINE, 56巻, 22号, pp. 3003-3008, 2017
  36. Severe hypocalcemia and prolonged QT interval due to denosumab in an elderly woman with rheumatoid arthritis and chronic kidney disease., European journal of rheumatology, 3巻, 3号, pp. 144-145, 201609
  37. Successful treatment of FKBP51-expressed multicentric reticulohistiocytosis using combination therapy with low-dose denosumab and tacrolimus, SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 45巻, 3号, pp. 247-248, 201605
  38. Non-autoimmune combined factor XIII A and B subunit deficiencies in rheumatoid arthritis patients treated with anti-interleukin-6 receptor monoclonal antibody (tocilizumab), THROMBOSIS RESEARCH, 140巻, pp. 100-105, 201604
  39. Study on the frequency and risk factors of moderate-to-severe sleep apnea syndrome in rheumatoid arthritis, MODERN RHEUMATOLOGY, 26巻, 5号, pp. 681-684, 2016
  40. Nod2-Nodosome in a Cell-Free System: Implications in Pathogenesis and Drug Discovery for Blau Syndrome and Early-Onset Sarcoidosis., The Scientific World Journal, 2016巻, pp. 2597376-2597376, 2016
  41. Reconstituted AIM2 inflammasome in cell-free system, JOURNAL OF IMMUNOLOGICAL METHODS, 426巻, pp. 76-81, 201511
  42. ★, CD1a(+) survivin(+) dendritic cell infiltration in dermal lesions of systemic sclerosis, ARTHRITIS RESEARCH & THERAPY, 17巻, pp. 275, 201509
  43. ★, The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes, SCIENTIFIC REPORTS, 5巻, pp. 9795, 201505
  44. Undercarboxylated osteocalcin may be an attractive marker of teriparatide treatment in rheumatoid arthritis patients, OSTEOPOROSIS INTERNATIONAL, 26巻, 4号, pp. 1443-1443, 201504
  45. Epstein-Barr virus-related MTX-LPD in rheumatoid arthritis patients exhibits a viral pattern of the CD64 and CD35 expression on neutrophils: Three case reports, MODERN RHEUMATOLOGY, 25巻, 1号, pp. 166-168, 201501
  46. Comparison of the clinical utility of tocilizumab and anti-TNF therapy in AA amyloidosis complicating rheumatic diseases, MODERN RHEUMATOLOGY, 24巻, 1号, pp. 137-143, 201401
  47. Defect of suppression of inflammasome-independent interleukin-8 secretion from SW982 synovial sarcoma cells by familial Mediterranean fever-derived pyrin mutations, MOLECULAR BIOLOGY REPORTS, 41巻, 1号, pp. 545-553, 201401
  48. Tocilizumab improved clinical symptoms of a patient with systemic tophaceous gout who had symmetric polyarthritis and fever: An alternative treatment by blockade of interleukin-6 signaling., SAGE open medical case reports, 2巻, pp. 2050313X13519774, 2014
  49. ★, Tocilizumab Induced Acquired Factor XIII Deficiency in Patients with Rheumatoid Arthritis, PLOS ONE, 8巻, 8号, pp. e69944, 201308
  50. D-penicillamine-induced glomerulonephritis with crescent formation: Remission following drug discontinuation, Indian Journal of Nephrology, 23巻, 3号, pp. 226-228, 2013
  51. Serum undercarboxylated osteocalcin level increases with 48 weeks of teriparatide treatment in pre-treated elderly rheumatoid arthritis patients who use anti-resorptive drugs, JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 35巻, 9号, pp. 796-799, 201210
  52. Simultaneous quantitative analysis of the expression of CD64 and CD35 on neutrophils as markers to differentiate between bacterial and viral infections in patients with rheumatoid arthritis, MODERN RHEUMATOLOGY, 22巻, 5号, pp. 750-757, 201209
  53. Post-menopausal women with rheumatoid arthritis who are treated with raloxifene or alendronate or glucocorticoids have lower serum undercarboxylated osteocalcin levels, JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 35巻, 7号, pp. 661-664, 201207
  54. Successful tocilizumab treatment in a patient with adult-onset Still's disease complicated by chronic active hepatitis B and amyloid A amyloidosis, MODERN RHEUMATOLOGY, 21巻, 2号, pp. 215-218, 201104
  55. Clinical Images: Bone histomorphometric analysis of SAPHO syndrome with sternoclavicular hyperostosis, ARTHRITIS AND RHEUMATISM, 62巻, 11号, pp. 3364-3364, 201011

招待講演、口頭・ポスター発表等

  1. Tocilizumab Induced Acquired Factor XIII Deficiency In Patients with Rheumatoid Arthritis., Mokuda S, Murata Y, Sawada N, Matoba K, Yamada A, Onishi M, Okuda Y, Jouyama K, Sugiyama E, Takasugi K., 国際XIII因子シンポジウム, 2014年02月12日, 招待, 英語, ウイーン、オーストリア

受賞

  1. 2022年08月05日, 第43回日本炎症・再生医学会 優秀演題賞
  2. 2021年04月, 令和3年度 日本リウマチ学会 奨励賞
  3. 2020年11月, 2020年度 日本臨床検査医学会 若手研究者奨励賞
  4. 2019年04月, 日本リウマチ学会 JCR2019 国際ワークショップ優秀演題賞
  5. 2016年06月, 第19回 広仁会基礎医学研究賞
  6. 2014年01月, エクセレント・スチューデント・スカラシップ(広島大学大学院)
  7. 2013年12月, 第24回 日本リウマチ学会 中国・四国支部学術集会 若手奨励賞
  8. 2008年02月, 第8回 日本内分泌学会関東甲信越支部学術集会 研修医奨励賞

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業 若手研究, ゲノム編集法を用いた関節リウマチ滑膜におけるサバイビンバリアントの役割の解明, 2019年, 2023年
  2. 科学研究費助成事業 基盤研究(C), 炎症性サイトカインによる宿主受容体発現調節を利用したCOVID-19治療薬の開発, 2022年, 2025年
  3. 中冨健康科学振興財団 研究助成, 関節軟骨恒常性に寄与するユビキチン化酵素Wwp2の機能解析と遺伝子導入法の開発, 2022年, 2024年
  4. 冲中記念成人病研究所 研究助成, 炎症性サイトカインによる宿主受容体制御を介した新型コロナウイルス治療薬の開発, 2022年, 2023年
  5. 日本リウマチ学会 早期RA研究推進プログラム, 関節リウマチ早期における軟骨損傷の抑制を目指したmRNA医薬の開発に関する基礎的研究, 2021年, 2022年
  6. 日本リウマチ財団 リウマチ性疾患調査・研究助成, 関節滑膜のアポトーシスを制御しうるイントロン型マイクロRNA・宿主遺伝子の機能的協調性の解析と核酸医薬への展開, 2021年, 2022年
  7. 持田記念医学薬学振興財団 2020年度 研究助成, イントロン型マイクロRNA・宿主遺伝子間の協調的機能の解析とその相乗効果を利用した関節用核酸医薬の開発, 2020年, 2021年
  8. 武田科学振興財団 医学系研究助成, イントロン型マイクロRNA・宿主遺伝子間の協調的機能の解析とその相乗効果を利用した関節疾患に対する核酸医薬の開発, 2020年, 2023年
  9. 日本呼吸器財団 COVID-19関連研究助成, IL‐6‐STAT3系を介したSARS‐CoV‐2受容体ACE2の発現調節機構の解明, 2020年, 2022年
  10. 三菱財団 自然科学研究助成(若手), イントロン型マイクロRNA・宿主遺伝子間の協調的機能の解析とその相乗効果を利用した核酸医薬への応用, 2020年, 2022年
  11. 日本リウマチ財団 平成27年度 海外派遣研修医, 関節リウマチ等におけるLong-non coding RNA分子機構の解明, 2015年, 2016年
  12. 上原記念生命科学財団 海外留学助成リサーチフェローシップ, 関節リウマチ等におけるLong-non coding RNA分子機構の解明, 2015年, 2017年