SHO MOKUDA
Last Updated :2025/04/03
- Affiliations, Positions
- Hiroshima University Hospital(Division of Laboratory Medicine), Associate Professor
- E-mail
- sho-mokuda
hiroshima-u.ac.jp
Basic Information
Major Professional Backgrounds
- 2015/10/27, 2018/08/17, The Scripps Research Institute, Deparment of Molecular and Experimental Medicine, Research Associate
- 2009/08/01, 2013/03/31, Dohgo Spa Hospital, Center of Rheumatic Diseases, Medical Doctor of Internal Mecine
- 2006/04/01, 2009/07/31, Toranomon Hospital, Internal Medicine, Clinical Resident
Academic Degrees
In Charge of Primary Major Programs
Research Fields
- Medicine,dentistry, and pharmacy;Clinical internal medicine;Collagenous pathology / Allergology
Research Keywords
Affiliated Academic Societies
- Japan College of Rheumatology
- Japanese Society of Laboratory Medicine
- The Japanese Society of Internal Medicine
- The Japanese Society of Clinical Immunology
- The Japanese Society of Inflammation and Regeneration.
Research Activities
Academic Papers
- Disseminated Mycobacterium abscessus infection with osteoarticular manifestations as an important differential diagnosis of inflammatory arthritis: A case report and literature review, MODERN RHEUMATOLOGY CASE REPORTS, 8(1), 49-54, 20231229
- Seasonal Influence on Development of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Retrospective Cohort Study Conducted at Multiple Institutions in Japan ( J- CANVAS), JOURNAL OF RHEUMATOLOGY, 50(9), 1152-1158, 20230901
- Tumor Necrosis Factor and Interleukin-1 beta Upregulate NRP2 Expression and Promote SARS-CoV-2 Proliferation, VIRUSES-BASEL, 15(7), 202307
- Cryoglobulinemic Vasculitis Associated with Monoclonal Gammopathy of Undetermined Significance Developed after Sustained Virologic Response of Hepatitis C, INTERNAL MEDICINE, 62(13), 1999-2004, 2023
- Safe Introduction of Hydroxychloroquine Focusing on Early Intolerance Due to Adverse Drug Reactions in Patients with Systemic Lupus Erythematosus, INTERNAL MEDICINE, 62(14), 2051-2057, 2023
- Appearance of anti-MDA5 antibody-positive dermatomyositis after COVID-19 vaccination, MODERN RHEUMATOLOGY CASE REPORTS, 7(1), 108-112, 20230103
- Association between increased serum IL-23 levels and ACPA positivity in patients with rheumatoid arthritis, Clinical and Experimental Rheumatology, 41(5), 1198-1199, 202305
- Ameliorated nailfold capillary morphology of patients with pulmonary arterial hypertension in systemic sclerosis, treated with riociguat, Rheumatology Advances in Practice, 20230119
- ★, Expression of factor XIII originating from synovial fibroblasts and macrophages induced by interleukin-6 signaling, INFLAMMATION AND REGENERATION, 43(1), 20230106
- Anti-spike protein antibody responses to BNT162b2 mRNA vaccine: A single-center survey in a COVID-19 non-epidemic area in Japan, VACCINE: X, 11, 202208
- N1-methylpseudouridine-incorporated mRNA enhances exogenous protein expression and suppresses immunogenicity in primary human fibroblast-like synoviocytes, CYTOTECHNOLOGY, 74(4), 503-514, 202208
- C-reactive protein and ground-glass opacity as predictors for intractable interstitial lung disease in patients with systemic sclerosis under cyclophosphamide treatment regardless of concomitant glucocorticoids, MODERN RHEUMATOLOGY, 32(1), 141-148, 20220105
- The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient, INTERNAL MEDICINE, 61(11), 1785-1788, 2022
- The Lipopolysaccharide Mutant Re-LPS Is a Useful Tool for Detecting LPS Contamination in Rheumatoid Synovial Cell Cultures, Pathobiology, 89(2), 92-100, 2022
- Comment on: Combination of immunosuppressive therapy and nintedanib improves capillaroscopic changes in systemic sclerosis-interstitial lung disease: a case report, Rheumatology Advances in Practice, 6(1), rkac024., 2022
- Comment on: Nailfold capillaries and myositis-specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive DM. Reply, Rheumatology (Oxford), 61(5), e122-e124, 2022
- The clinical characteristics and predictors of severe digital ischemia in patients with anti-aminoacyl transfer RNA synthetase antibodies, The Journal of Dermatology, 48(7), 1044-1051, 2021
- Tapering and discontinuation of oral glucocorticoids without deterioration of disease status in patients with rheumatoid arthritis under a stable treatment, Modern Rheumatology, 31(4), 803-808, 2021
- Lower CH50 as a predictor for intractable or recurrent lupus enteritis: A retrospective observational study, Modern Rheumatology, 31(3), 643-648, 2021
- Activin A Expressed in Rheumatoid Synovial Cells Downregulates TNFalpha-Induced CXCL10 Expression and Osteoclastogenesis, Pathobiology, 87(3), 198-207, 2020
- Serum CXCL10 levels are associated with better responses to abatacept treatment of rheumatoid arthritis, Clinical and Experimental Rheumatology, 38(5), 956-963, 2020
- Evaluation of 48-week daily teriparatide treatment with DXA-based hip structure analysis in elderly female patients with rheumatoid arthritis, Medical Research Archives, 3, 3, 20150430
- Asymptomatic coronary aneurysms in a patient with eosinophilic granulomatosis with polyangiitis who developed a digital gangrene, Modern Rheumatology Case Reports, 5(1), 130-136, 2021
- Immunoglobulin D-kappa multiple myeloma in a patient with rheumatoid arthritis: a case report and review of the literature, Modern Rheumatology Case Reports, 5(1), 22-28, 2021
- Successful hydroxychloroquine treatment in a patient with systemic lupus erythematosus-associated nailfold capillary abnormalities, Rheumatology Advances in Practice, 4(2), rkaa060, 20201105
- Nailfold capillaries and myositis-specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis, RHEUMATOLOGY (Oxford), 61(5), 2006-2015, 20220505
- Rapid changes of nailfold capillary abnormalities during treatment for a patient with dermatomyositis complicated by lung cancer: a case report., Modern Rheumatology Case Reports, 5, 95-100, 2021
- Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s., Scientific Reports, 11, 13109, 2021
- Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2alpha expression and coordinately regulate cartilage homeostasis., Nature Communications, 12, 4148, 2021
- ★, Angiotensin-converting enzyme 2, a SARS-CoV-2 receptor, is upregulated by interleukin-6 through STAT3 signaling in synovial tissues, The Journal of Rheumatology, jrheum.200547-jrheum.200547, 20200701
- TGFbeta1 Regulates Human RANKL-Induced Osteoclastogenesis via Suppression of NFATc1 Expression, International Journal of Molecular Sciences, 21, 800, 2020
- Successful hydroxychloroquine treatment in a patient with SLE-associated nailfold capillary abnormalities., Rheumatology Advances in Practice, 4, rka060, 2020
- Methotrexate-associated reversible liver atrophy in a patient with rheumatoid arthritis, Rheumatology Advances in Practice, 4, rkaa014, 2020
- Large-vessel vasculitis associated with PEGylated granulocyte-colony stimulating factor, NETHERLANDS JOURNAL OF MEDICINE, 77(6), 224-226, 201907
- Tumour necrosis factor alpha augments the inhibitory effects of CTLA-4-Ig on osteoclast generation from human monocytes via induction of CD80 expression, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 196(3), 392-402, 201906
- ★, Wwp2 maintains cartilage homeostasis through regulation of Adamts5., Nature communications, 10(1), 2429, 201906
- FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration., Aging cell, 17(5), e12800-e12800, 201807
- ★, Dissecting the roles of miR-140 and its host gene, Nature Cell Biology, 20(5), 516-518, 20180501
- FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis., Science translational medicine, 10(428), 201802
- The prevalence of endoscopic gastric mucosal damage in patients with rheumatoid arthritis., PLoS one, 13(7), e0200023, 2018
- Bisulfite sequencing for DNA methylation analysis of primary muscle stem cells, Methods in Molecular Biology, 1668, 3-13, 2017
- Neurological Complications in Eosinophilic Granulomatosis with Polyangiitis (EGPA): The Roles of History and Physical Examinations in the Diagnosis of EGPA, INTERNAL MEDICINE, 56(22), 3003-3008, 2017
- Severe hypocalcemia and prolonged QT interval due to denosumab in an elderly woman with rheumatoid arthritis and chronic kidney disease., European journal of rheumatology, 3(3), 144-145, 201609
- Successful treatment of FKBP51-expressed multicentric reticulohistiocytosis using combination therapy with low-dose denosumab and tacrolimus, SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 45(3), 247-248, 201605
- Non-autoimmune combined factor XIII A and B subunit deficiencies in rheumatoid arthritis patients treated with anti-interleukin-6 receptor monoclonal antibody (tocilizumab), THROMBOSIS RESEARCH, 140, 100-105, 201604
- Study on the frequency and risk factors of moderate-to-severe sleep apnea syndrome in rheumatoid arthritis, MODERN RHEUMATOLOGY, 26(5), 681-684, 2016
- Nod2-Nodosome in a Cell-Free System: Implications in Pathogenesis and Drug Discovery for Blau Syndrome and Early-Onset Sarcoidosis., The Scientific World Journal, 2016, 2597376-2597376, 2016
- Reconstituted AIM2 inflammasome in cell-free system, JOURNAL OF IMMUNOLOGICAL METHODS, 426, 76-81, 201511
- ★, CD1a(+) survivin(+) dendritic cell infiltration in dermal lesions of systemic sclerosis, ARTHRITIS RESEARCH & THERAPY, 17, 275, 201509
- ★, The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes, SCIENTIFIC REPORTS, 5, 9795, 201505
- Undercarboxylated osteocalcin may be an attractive marker of teriparatide treatment in rheumatoid arthritis patients, OSTEOPOROSIS INTERNATIONAL, 26(4), 1443-1443, 201504
- Epstein-Barr virus-related MTX-LPD in rheumatoid arthritis patients exhibits a viral pattern of the CD64 and CD35 expression on neutrophils: Three case reports, MODERN RHEUMATOLOGY, 25(1), 166-168, 201501
- Comparison of the clinical utility of tocilizumab and anti-TNF therapy in AA amyloidosis complicating rheumatic diseases, MODERN RHEUMATOLOGY, 24(1), 137-143, 201401
- Defect of suppression of inflammasome-independent interleukin-8 secretion from SW982 synovial sarcoma cells by familial Mediterranean fever-derived pyrin mutations, MOLECULAR BIOLOGY REPORTS, 41(1), 545-553, 201401
- Tocilizumab improved clinical symptoms of a patient with systemic tophaceous gout who had symmetric polyarthritis and fever: An alternative treatment by blockade of interleukin-6 signaling., SAGE open medical case reports, 2, 2050313X13519774, 2014
- ★, Tocilizumab Induced Acquired Factor XIII Deficiency in Patients with Rheumatoid Arthritis, PLOS ONE, 8(8), e69944, 201308
- D-penicillamine-induced glomerulonephritis with crescent formation: Remission following drug discontinuation, Indian Journal of Nephrology, 23(3), 226-228, 2013
- Serum undercarboxylated osteocalcin level increases with 48 weeks of teriparatide treatment in pre-treated elderly rheumatoid arthritis patients who use anti-resorptive drugs, JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 35(9), 796-799, 201210
- Simultaneous quantitative analysis of the expression of CD64 and CD35 on neutrophils as markers to differentiate between bacterial and viral infections in patients with rheumatoid arthritis, MODERN RHEUMATOLOGY, 22(5), 750-757, 201209
- Post-menopausal women with rheumatoid arthritis who are treated with raloxifene or alendronate or glucocorticoids have lower serum undercarboxylated osteocalcin levels, JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 35(7), 661-664, 201207
- Successful tocilizumab treatment in a patient with adult-onset Still's disease complicated by chronic active hepatitis B and amyloid A amyloidosis, MODERN RHEUMATOLOGY, 21(2), 215-218, 201104
- Clinical Images: Bone histomorphometric analysis of SAPHO syndrome with sternoclavicular hyperostosis, ARTHRITIS AND RHEUMATISM, 62(11), 3364-3364, 201011
Invited Lecture, Oral Presentation, Poster Presentation
- Proinflammatory cytokines regulate expression of host receptors for SARS-CoV-2, 2023/04/29, With Invitation, Japanese, Tokyo, Japan
- Tocilizumab Induced Acquired Factor XIII Deficiency In Patients with Rheumatoid Arthritis., Mokuda S, Murata Y, Sawada N, Matoba K, Yamada A, Onishi M, Okuda Y, Jouyama K, Sugiyama E, Takasugi K., International Factor XIII symposium, 2014/02/12, With Invitation, English, Vienna, Austria