Last Updated :2023/09/05

Affiliations, Positions
Hiroshima University Hospital(Division of Laboratory Medicine), Associate Professor

Basic Information

Major Professional Backgrounds

  • 2015/10/27, 2018/08/17, The Scripps Research Institute, Deparment of Molecular and Experimental Medicine, Research Associate
  • 2009/08/01, 2013/03/31, Dohgo Spa Hospital, Center of Rheumatic Diseases, Medical Doctor of Internal Mecine
  • 2006/04/01, 2009/07/31, Toranomon Hospital, Internal Medicine, Clinical Resident

Academic Degrees

  • Hiroshima University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Collagenous pathology / Allergology

Research Keywords

  • Rheumatology

Affiliated Academic Societies

  • Japan College of Rheumatology
  • Japanese Society of Laboratory Medicine
  • The Japanese Society of Internal Medicine
  • The Japanese Society of Clinical Immunology
  • The Japanese Society of Inflammation and Regeneration.

Educational Activity

Course in Charge

  1. 2023, Undergraduate Education, Year, Clinical diagnosis and treatment II

Research Activities

Academic Papers

  1. Appearance of anti-MDA5 antibody-positive dermatomyositis after COVID-19 vaccination, MODERN RHEUMATOLOGY CASE REPORTS, 7(1), 108-112, 20230103
  2. Cryoglobulinemic Vasculitis Associated with Monoclonal Gammopathy of Undetermined Significance Developed after Sustained Virologic Response of Hepatitis C: A Case Report, Internal Medicine, 20221116
  3. Association between increased serum IL-23 levels and ACPA positivity in patients with rheumatoid arthritis, Clinical and Experimental Rheumatology, 41(5), 1198-1199, 202305
  4. Ameliorated nailfold capillary morphology of patients with pulmonary arterial hypertension in systemic sclerosis, treated with riociguat, Rheumatology Advances in Practice, 20230119
  5. Seasonal influence on development of anti-neutrophil cytoplasmic antibody-associated vasculitis: a retrospective cohort study conducted at multiple institutions in Japan (J-CANVAS), Journal of Rheumatology, 20230601
  6. ★, Expression of factor XIII originating from synovial fibroblasts and macrophages induced by interleukin-6 signaling, INFLAMMATION AND REGENERATION, 43(1), 20230106
  7. Anti-spike protein antibody responses to BNT162b2 mRNA vaccine: A single-center survey in a COVID-19 non-epidemic area in Japan, VACCINE: X, 11, 202208
  8. N1-methylpseudouridine-incorporated mRNA enhances exogenous protein expression and suppresses immunogenicity in primary human fibroblast-like synoviocytes, CYTOTECHNOLOGY, 74(4), 503-514, 202208
  9. C-reactive protein and ground-glass opacity as predictors for intractable interstitial lung disease in patients with systemic sclerosis under cyclophosphamide treatment regardless of concomitant glucocorticoids, MODERN RHEUMATOLOGY, 32(1), 141-148, 20220105
  10. The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient, INTERNAL MEDICINE, 61(11), 1785-1788, 2022
  11. The Lipopolysaccharide Mutant Re-LPS Is a Useful Tool for Detecting LPS Contamination in Rheumatoid Synovial Cell Cultures, Pathobiology, 89(2), 92-100, 2022
  12. Comment on: Combination of immunosuppressive therapy and nintedanib improves capillaroscopic changes in systemic sclerosis-interstitial lung disease: a case report, Rheumatology Advances in Practice, 6(1), rkac024., 2022
  13. Comment on: Nailfold capillaries and myositis-specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive DM. Reply, Rheumatology (Oxford), 61(5), e122-e124, 2022
  14. The clinical characteristics and predictors of severe digital ischemia in patients with anti-aminoacyl transfer RNA synthetase antibodies, The Journal of Dermatology, 48(7), 1044-1051, 2021
  15. Tapering and discontinuation of oral glucocorticoids without deterioration of disease status in patients with rheumatoid arthritis under a stable treatment, Modern Rheumatology, 31(4), 803-808, 2021
  16. Lower CH50 as a predictor for intractable or recurrent lupus enteritis: A retrospective observational study, Modern Rheumatology, 31(3), 643-648, 2021
  17. Activin A Expressed in Rheumatoid Synovial Cells Downregulates TNFalpha-Induced CXCL10 Expression and Osteoclastogenesis, Pathobiology, 87(3), 198-207, 2020
  18. Serum CXCL10 levels are associated with better responses to abatacept treatment of rheumatoid arthritis, Clinical and Experimental Rheumatology, 38(5), 956-963, 2020
  19. Evaluation of 48-week daily teriparatide treatment with DXA-based hip structure analysis in elderly female patients with rheumatoid arthritis, Medical Research Archives, 3, 3, 20150430
  20. Asymptomatic coronary aneurysms in a patient with eosinophilic granulomatosis with polyangiitis who developed a digital gangrene, Modern Rheumatology Case Reports, 5(1), 130-136, 2021
  21. Immunoglobulin D-kappa multiple myeloma in a patient with rheumatoid arthritis: a case report and review of the literature, Modern Rheumatology Case Reports, 5(1), 22-28, 2021
  22. Successful hydroxychloroquine treatment in a patient with systemic lupus erythematosus-associated nailfold capillary abnormalities, Rheumatology Advances in Practice, 4(2), rkaa060, 20201105
  23. Nailfold capillaries and myositis-specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis, RHEUMATOLOGY (Oxford), 61(5), 2006-2015, 20220505
  24. Rapid changes of nailfold capillary abnormalities during treatment for a patient with dermatomyositis complicated by lung cancer: a case report., Modern Rheumatology Case Reports, 5, 95-100, 2021
  25. Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s., Scientific Reports, 11, 13109, 2021
  26. Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2alpha expression and coordinately regulate cartilage homeostasis., Nature Communications, 12, 4148, 2021
  27. ★, Angiotensin-converting enzyme 2, a SARS-CoV-2 receptor, is upregulated by interleukin-6 through STAT3 signaling in synovial tissues, The Journal of Rheumatology, jrheum.200547-jrheum.200547, 20200701
  28. TGFbeta1 Regulates Human RANKL-Induced Osteoclastogenesis via Suppression of NFATc1 Expression, International Journal of Molecular Sciences, 21, 800, 2020
  29. Successful hydroxychloroquine treatment in a patient with SLE-associated nailfold capillary abnormalities., Rheumatology Advances in Practice, 4, rka060, 2020
  30. Methotrexate-associated reversible liver atrophy in a patient with rheumatoid arthritis, Rheumatology Advances in Practice, 4, rkaa014, 2020
  31. Large-vessel vasculitis associated with PEGylated granulocyte-colony stimulating factor, NETHERLANDS JOURNAL OF MEDICINE, 77(6), 224-226, 201907
  32. Tumour necrosis factor alpha augments the inhibitory effects of CTLA-4-Ig on osteoclast generation from human monocytes via induction of CD80 expression, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 196(3), 392-402, 201906
  33. ★, Wwp2 maintains cartilage homeostasis through regulation of Adamts5., Nature communications, 10(1), 2429, 201906
  34. FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration., Aging cell, 17(5), e12800-e12800, 201807
  35. ★, Dissecting the roles of miR-140 and its host gene, Nature Cell Biology, 20(5), 516-518, 20180501
  36. FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis., Science translational medicine, 10(428), 201802
  37. The prevalence of endoscopic gastric mucosal damage in patients with rheumatoid arthritis., PLoS one, 13(7), e0200023, 2018
  38. Bisulfite sequencing for DNA methylation analysis of primary muscle stem cells, Methods in Molecular Biology, 1668, 3-13, 2017
  39. Neurological Complications in Eosinophilic Granulomatosis with Polyangiitis (EGPA): The Roles of History and Physical Examinations in the Diagnosis of EGPA, INTERNAL MEDICINE, 56(22), 3003-3008, 2017
  40. Severe hypocalcemia and prolonged QT interval due to denosumab in an elderly woman with rheumatoid arthritis and chronic kidney disease., European journal of rheumatology, 3(3), 144-145, 201609
  41. Successful treatment of FKBP51-expressed multicentric reticulohistiocytosis using combination therapy with low-dose denosumab and tacrolimus, SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 45(3), 247-248, 201605
  42. Non-autoimmune combined factor XIII A and B subunit deficiencies in rheumatoid arthritis patients treated with anti-interleukin-6 receptor monoclonal antibody (tocilizumab), THROMBOSIS RESEARCH, 140, 100-105, 201604
  43. Study on the frequency and risk factors of moderate-to-severe sleep apnea syndrome in rheumatoid arthritis, MODERN RHEUMATOLOGY, 26(5), 681-684, 2016
  44. Nod2-Nodosome in a Cell-Free System: Implications in Pathogenesis and Drug Discovery for Blau Syndrome and Early-Onset Sarcoidosis., The Scientific World Journal, 2016, 2597376-2597376, 2016
  45. Reconstituted AIM2 inflammasome in cell-free system, JOURNAL OF IMMUNOLOGICAL METHODS, 426, 76-81, 201511
  46. ★, CD1a(+) survivin(+) dendritic cell infiltration in dermal lesions of systemic sclerosis, ARTHRITIS RESEARCH & THERAPY, 17, 275, 201509
  47. ★, The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes, SCIENTIFIC REPORTS, 5, 9795, 201505
  48. Undercarboxylated osteocalcin may be an attractive marker of teriparatide treatment in rheumatoid arthritis patients, OSTEOPOROSIS INTERNATIONAL, 26(4), 1443-1443, 201504
  49. Epstein-Barr virus-related MTX-LPD in rheumatoid arthritis patients exhibits a viral pattern of the CD64 and CD35 expression on neutrophils: Three case reports, MODERN RHEUMATOLOGY, 25(1), 166-168, 201501
  50. Comparison of the clinical utility of tocilizumab and anti-TNF therapy in AA amyloidosis complicating rheumatic diseases, MODERN RHEUMATOLOGY, 24(1), 137-143, 201401
  51. Defect of suppression of inflammasome-independent interleukin-8 secretion from SW982 synovial sarcoma cells by familial Mediterranean fever-derived pyrin mutations, MOLECULAR BIOLOGY REPORTS, 41(1), 545-553, 201401
  52. Tocilizumab improved clinical symptoms of a patient with systemic tophaceous gout who had symmetric polyarthritis and fever: An alternative treatment by blockade of interleukin-6 signaling., SAGE open medical case reports, 2, 2050313X13519774, 2014
  53. ★, Tocilizumab Induced Acquired Factor XIII Deficiency in Patients with Rheumatoid Arthritis, PLOS ONE, 8(8), e69944, 201308
  54. D-penicillamine-induced glomerulonephritis with crescent formation: Remission following drug discontinuation, Indian Journal of Nephrology, 23(3), 226-228, 2013
  55. Serum undercarboxylated osteocalcin level increases with 48 weeks of teriparatide treatment in pre-treated elderly rheumatoid arthritis patients who use anti-resorptive drugs, JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 35(9), 796-799, 201210
  56. Simultaneous quantitative analysis of the expression of CD64 and CD35 on neutrophils as markers to differentiate between bacterial and viral infections in patients with rheumatoid arthritis, MODERN RHEUMATOLOGY, 22(5), 750-757, 201209
  57. Post-menopausal women with rheumatoid arthritis who are treated with raloxifene or alendronate or glucocorticoids have lower serum undercarboxylated osteocalcin levels, JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 35(7), 661-664, 201207
  58. Successful tocilizumab treatment in a patient with adult-onset Still's disease complicated by chronic active hepatitis B and amyloid A amyloidosis, MODERN RHEUMATOLOGY, 21(2), 215-218, 201104
  59. Clinical Images: Bone histomorphometric analysis of SAPHO syndrome with sternoclavicular hyperostosis, ARTHRITIS AND RHEUMATISM, 62(11), 3364-3364, 201011

Invited Lecture, Oral Presentation, Poster Presentation

  1. Proinflammatory cytokines regulate expression of host receptors for SARS-CoV-2, 2023/04/29, With Invitation, Japanese
  2. Tocilizumab Induced Acquired Factor XIII Deficiency In Patients with Rheumatoid Arthritis., Mokuda S, Murata Y, Sawada N, Matoba K, Yamada A, Onishi M, Okuda Y, Jouyama K, Sugiyama E, Takasugi K., International Factor XIII symposium, 2014/02/12, With Invitation, English, Vienna, Austria