渡邉 朋信TOMONOBU WATANABE
Last Updated :2023/03/03
- 所属・職名
- 原爆放射線医科学研究所 教授
- メールアドレス
- twatanabe
hiroshima-u.ac.jp
基本情報
学位
- 修士(理学) (大阪大学)
- 博士(理学) (大阪大学)
教育活動
授業担当
- 2022年, 学部専門, 集中, 医学研究実習
- 2022年, 修士課程・博士課程前期, セメスター(前期), 特別演習
- 2022年, 修士課程・博士課程前期, セメスター(後期), 特別演習
- 2022年, 修士課程・博士課程前期, セメスター(前期), 特別研究
- 2022年, 修士課程・博士課程前期, セメスター(後期), 特別研究
- 2022年, 博士課程・博士課程後期, セメスター(前期), 特別演習
- 2022年, 博士課程・博士課程後期, セメスター(後期), 特別演習
- 2022年, 博士課程・博士課程後期, セメスター(前期), 特別研究
- 2022年, 博士課程・博士課程後期, セメスター(後期), 特別研究
- 2022年, 博士課程・博士課程後期, セメスター(前期), 幹細胞機能学特別演習
- 2022年, 博士課程・博士課程後期, セメスター(後期), 幹細胞機能学特別演習
- 2022年, 博士課程・博士課程後期, セメスター(前期), 幹細胞機能学特別研究
- 2022年, 博士課程・博士課程後期, セメスター(後期), 幹細胞機能学特別研究
- 2022年, 修士課程・博士課程前期, 3ターム, 生命医科学セミナー A
- 2022年, 修士課程・博士課程前期, 3ターム, 生命医科学セミナー B
- 2022年, 博士課程・博士課程後期, 3ターム, 生命医科学セミナーC
- 2022年, 博士課程・博士課程後期, 3ターム, 生命医科学セミナーD
- 2022年, 博士課程・博士課程後期, 3ターム, 生命医科学セミナーE
研究活動
学術論文(★は代表的な論文)
- Mitochondria-associated myosin 19 processively transports mitochondria on actin tracks in living cells, Journal of Biological Chemistry, 20220320
- Lattice-patterned collagen fibers and their dynamics in axolotl skin regeneration, ISCIENCE, 25巻, 7号, 20220715
- Valosin-containing protein regulates the stability of fused in sarcoma granules in cells by changing ATP concentrations, FEBS LETTERS, 596巻, 11号, pp. 1412-1423, 202206
- Non-label immune cell state prediction using Raman spectroscopy., Scientific reports, 6巻, 2016
- Single- and multiple-molecule dynamics of the signaling from H-Ras to cRaf-1 visualized on the plasma membrane of living cells., Chemphyschem : a European journal of chemical physics and physical chemistry, 4巻, 7号, 2003
- A one-headed class V myosin molecule develops multiple large (approximately 32-nm) steps successively., Proceedings of the National Academy of Sciences of the United States of America, 101巻, 26号, 2004
- Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein., Journal of cell science, 119巻, Pt 6号, 2006
- Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein., Proceedings of the National Academy of Sciences of the United States of America, 103巻, 15号, 2006
- Reduction in nonfluorescence state of quantum dots on an immunofluorescence staining., Biochemical and biophysical research communications, 351巻, 1号, 2006
- Input-output relationship in galvanotactic response of Dictyostelium cells., Bio Systems, 88巻, 3号, 2007
- Stepwise movements in vesicle transport of HER2 by motor proteins in living cells., Biophysical journal, 92巻, 11号, 2007
- Three-dimensional nanometry of vesicle transport in living cells using dual-focus imaging optics., Biochemical and biophysical research communications, 359巻, 1号, 2007
- Human myosin Vc is a low duty ratio nonprocessive motor., The Journal of biological chemistry, 283巻, 16号, 2008
- In vivo nano-imaging of membrane dynamics in metastatic tumor cells using quantum dots., The Journal of biological chemistry, 285巻, 4号, 2010
- Myosin-X induces filopodia by multiple elongation mechanism., The Journal of biological chemistry, 285巻, 25号, 2010
- Single molecular observation of self-regulated kinesin motility., Biochemistry, 49巻, 22号, 2010
- Identification of three distinct functional sites of insulin-mediated GLUT4 trafficking in adipocytes using quantitative single molecule imaging., Molecular biology of the cell, 21巻, 15号, 2010
- Mechanical characterization of one-headed myosin-V using optical tweezers., PloS one, 5巻, 8号, 2010
- Antibody-protein A conjugated quantum dots for multiplexed imaging of surface receptors in living cells., Molecular bioSystems, 6巻, 11号, 2010
- Real-time nanoscopy by using blinking enhanced quantum dots., Biophysical journal, 99巻, 7号, 2010
- Synthesis and Characterization of Anti-HER2 Antibody Conjugated CdSe/CdZnS Quantum Dots for Fluorescence Imaging of Breast Cancer Cells., Sensors (Basel, Switzerland), 9巻, 11号, 2009
- Chromatin plasticity as a differentiation index during muscle differentiation of C2C12 myoblasts., Biochemical and biophysical research communications, 418巻, 4号, 2012
- Engineering strain-sensitive yellow fluorescent protein., Chemical communications (Cambridge, England), 48巻, 63号, 2012
- Atg9 vesicles are an important membrane source during early steps of autophagosome formation., The Journal of cell biology, 198巻, 2号, 2012
- Multilayered, core/shell nanoprobes based on magnetic ferric oxide particles and quantum dots for multimodality imaging of breast cancer tumors., Biomaterials, 33巻, 33号, 2012
- Distinct modulated pupil function system for real-time imaging of living cells., PloS one, 7巻, 9号, 2012
- Improving spinning disk confocal microscopy by preventing pinhole cross-talk for intravital imaging., Proceedings of the National Academy of Sciences of the United States of America, 110巻, 9号, 2013
- Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement., Nature communications, 4巻, 2013
- Four-dimensional spatial nanometry of single particles in living cells using polarized quantum rods., Biophysical journal, 105巻, 3号, 2013
- Glycine insertion makes yellow fluorescent protein sensitive to hydrostatic pressure., PloS one, 8巻, 8号, 2013
- Culturing of mouse and human cells on soft substrates promote the expression of stem cell markers., Journal of bioscience and bioengineering, 117巻, 6号, 2014
- Visualizing cell state transition using Raman spectroscopy., PloS one, 9巻, 1号, 2014
- Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis., Cell, 157巻, 3号, 2014
- Nano-scale measurement of biomolecules by optical microscopy and semiconductor nanoparticles., Frontiers in physiology, 5巻, 2014
- Gene dynamics of core transcription factors for pluripotency in embryonic stem cells., Journal of bioscience and bioengineering, 119巻, 4号, 2015
- Expanded palette of Nano-lanterns for real-time multicolor luminescence imaging., Proceedings of the National Academy of Sciences of the United States of America, 112巻, 14号, 2015
- Visualizing the appearance and disappearance of the attractor of differentiation using Raman spectral imaging., Scientific reports, 5巻, 2015
- SH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane., The FEBS journal, 282巻, 20号, 2015
- Predictive diagnosis of the risk of breast cancer recurrence after surgery by single-particle quantum dot imaging., Scientific reports, 5巻, 2015
- Full control of polarization state with a pair of electro-optic modulators for polarization-resolved optical microscopy., Applied optics, 55巻, 5号, 2016
- Dependence of fluorescent protein brightness on protein concentration in solution and enhancement of it., Scientific reports, 6巻, 2016
- Full control of polarization state with a pair of electro-optic modulators for polarization-resolved optical microscopy: erratum., Applied optics, 55巻, 15号, 2016
- Simultaneous nano-tracking of multiple motor proteins via spectral discrimination of quantum dots., Biomedical optics express, 7巻, 7号, 2016
- Activated full-length myosin-X moves processively on filopodia with large steps toward diverse two-dimensional directions., Scientific reports, 7巻, 2017
- Human myosin VIIa is a very slow processive motor protein on various cellular actin structures., The Journal of biological chemistry, 292巻, 26号, 2017
- Design and development of genetically encoded fluorescent sensors to monitor intracellular chemical and physical parameters., Biophysical reviews, 8巻, 2号, 2016
- A novel c-Src recruitment pathway from the cytosol to focal adhesions., FEBS letters, 591巻, 13号, 2017
- Raman spectroscopy as a tool for ecology and evolution., Journal of the Royal Society, Interface, 14巻, 131号, 2017
- In vivo analysis of protein crowding within the nuclear pore complex in interphase and mitosis., Scientific reports, 7巻, 1号, 2017
- The use of a genetically encoded molecular crowding sensor in various biological phenomena., Biophysics and physicobiology, 14巻, 2017
- Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation., Scientific reports, 7巻, 1号, 2017
- Validation of Common Housekeeping Genes as Reference for qPCR Gene Expression Analysis During iPS Reprogramming Process., Scientific reports, 8巻, 1号, 2018
- Cell type discrimination based on image features of molecular component distribution., Scientific reports, 8巻, 1号, 2018
- Single cell analysis reveals a biophysical aspect of collective cell-state transition in embryonic stem cell differentiation., Scientific reports, 8巻, 1号, 2018
- Raman spectral signature reflects transcriptomic features of antibiotic resistance in Escherichia coli., Communications biology, 1巻, 2018
- Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport., The Journal of cell biology, 217巻, 12号, 2018
- Single-Cell Screening of Tamoxifen Abundance and Effect Using Mass Spectrometry and Raman-Spectroscopy., Analytical chemistry, 91巻, 4号, 2019
- Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance., International immunology, 31巻, 11号, 2019
- Pairwise efficiency: a new mathematical approach to qPCR data analysis increases the precision of the calibration curve assay., BMC bioinformatics, 20巻, 1号, 2019
- Second harmonic generation polarization microscopy as a tool for protein structure analysis., Biophysics and physicobiology, 16巻, 2019
- Linking substrate and nucleus via actin cytoskeleton in pluripotency maintenance of mouse embryonic stem cells., Stem cell research, 41巻, 2019
- Advanced CUBIC tissue clearing for whole-organ cell profiling., Nature protocols, 14巻, 12号, 2019
- In vivo real-time tracking of single quantum dots conjugated with monoclonal anti-HER2 antibody in tumors of mice., Cancer research, 67巻, 3号, 2007
- An improved fluorescent protein-based expression reporter system that utilizes bioluminescence resonance energy transfer and peptide-assisted complementation, CHEMICAL COMMUNICATIONS, 56巻, 25号, pp. 3625-3628, 20200328
- Multiplexed 129 Xe HyperCEST MRI Detection of Genetically Reconstituted Bacterial Protein Nanoparticles in Human Cancer Cells, Contrast Media & Molecular Imaging, 2020
- Following Embryonic Stem Cells, Their Differentiated Progeny, and Cell-State Changes During iPS Reprogramming by Raman Spectroscopy, ANALYTICAL CHEMISTRY, 92巻, 22号, pp. 14915-14923, 20201117
- Quantitation of Cell Membrane Permeability of Cyclic Peptides by Single-Cell Cytoplasm Mass Spectrometry, ANALYTICAL CHEMISTRY, 93巻, 7号, pp. 3370-3377, 20210223
- Activation probability of a single naive T cell upon TCR ligation is controlled by T cells interacting with the same antigen-presenting cell, FEBS LETTERS, 595巻, 11号, pp. 1512-1524, 202106
- Glycine insertion modulates the fluorescence properties of Aequorea victoria green fluorescent protein and its variants in their ambient environment, BIOPHYSICS AND PHYSICOBIOLOGY, 18巻, pp. 145-158, 2021
- Improvement in image quality via the pseudo confocal effect in multidirectional digital scanned laser light-sheet microscopy, OPTICS EXPRESS, 29巻, 15号, pp. 24278-24288, 20210719
- Pressure-induced changes on the morphology and gene expression in mammalian cells, BIOLOGY OPEN, 10巻, 7号, 202107
- Exploring rare cellular activity in more than one million cells by a transscale scope, SCIENTIFIC REPORTS, 11巻, 1号, 20210816
招待講演、口頭・ポスター発表等
- ラマン散乱スペクトルの揺らぎによる細胞状態遷移予測, 渡邉朋信, 日本生化学会北陸支部シンポジウム, 2022年06月04日, 招待, 日本語
- 「豊か」になる考え方, 智辯学園奈良カレッジ講演会, 2021年10月30日, 招待, 日本語
- 光を当てただけ!?散乱光を用いた生命科学研究ツールの開発, 渡邉朋信, 統合生命科学研究科シンポジウム, 2021年06月21日, 招待, 日本語
- 光を当てただけ!?散乱光を用いた生命科学研究ツールの開発, 渡邉朋信, 神戸学院大学セミナー, 2021年07月21日, 招待, 日本語