渡邉 朋信TOMONOBU WATANABE

Last Updated :2021/02/01

所属・職名
原爆放射線医科学研究所 教授
メールアドレス
twatanabehiroshima-u.ac.jp

基本情報

学位

  • 修士(理学) (大阪大学)
  • 博士(理学) (大阪大学)

教育活動

授業担当

  1. 2020年, 博士課程・博士課程後期, セメスター(前期), 幹細胞機能学特別演習
  2. 2020年, 博士課程・博士課程後期, セメスター(後期), 幹細胞機能学特別演習
  3. 2020年, 博士課程・博士課程後期, セメスター(前期), 幹細胞機能学特別研究
  4. 2020年, 博士課程・博士課程後期, セメスター(後期), 幹細胞機能学特別研究

研究活動

学術論文(★は代表的な論文)

  1. Multiplexed 129 Xe HyperCEST MRI Detection of Genetically Reconstituted Bacterial Protein Nanoparticles in Human Cancer Cells, Contrast Media & Molecular Imaging
  2. An improved fluorescent protein-based expression reporter system that utilizes bioluminescence resonance energy transfer and peptide-assisted complementation, CHEMICAL COMMUNICATIONS, 56巻, 25号, pp. 3625-3628, 20200328
  3. Advanced CUBIC tissue clearing for whole-organ cell profiling., Nature protocols, 14巻, 12号, 2019
  4. Linking substrate and nucleus via actin cytoskeleton in pluripotency maintenance of mouse embryonic stem cells., Stem cell research, 41巻, 2019
  5. Second harmonic generation polarization microscopy as a tool for protein structure analysis., Biophysics and physicobiology, 16巻, 2019
  6. Pairwise efficiency: a new mathematical approach to qPCR data analysis increases the precision of the calibration curve assay., BMC bioinformatics, 20巻, 1号, 2019
  7. Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance., International immunology, 31巻, 11号, 2019
  8. Single-Cell Screening of Tamoxifen Abundance and Effect Using Mass Spectrometry and Raman-Spectroscopy., Analytical chemistry, 91巻, 4号, 2019
  9. Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport., The Journal of cell biology, 217巻, 12号, 2018
  10. Raman spectral signature reflects transcriptomic features of antibiotic resistance in Escherichia coli., Communications biology, 1巻, 2018
  11. Single cell analysis reveals a biophysical aspect of collective cell-state transition in embryonic stem cell differentiation., Scientific reports, 8巻, 1号, 2018
  12. Cell type discrimination based on image features of molecular component distribution., Scientific reports, 8巻, 1号, 2018
  13. Validation of Common Housekeeping Genes as Reference for qPCR Gene Expression Analysis During iPS Reprogramming Process., Scientific reports, 8巻, 1号, 2018
  14. Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation., Scientific reports, 7巻, 1号, 2017
  15. The use of a genetically encoded molecular crowding sensor in various biological phenomena., Biophysics and physicobiology, 14巻, 2017
  16. In vivo analysis of protein crowding within the nuclear pore complex in interphase and mitosis., Scientific reports, 7巻, 1号, 2017
  17. Raman spectroscopy as a tool for ecology and evolution., Journal of the Royal Society, Interface, 14巻, 131号, 2017
  18. A novel c-Src recruitment pathway from the cytosol to focal adhesions., FEBS letters, 591巻, 13号, 2017
  19. Human myosin VIIa is a very slow processive motor protein on various cellular actin structures., The Journal of biological chemistry, 292巻, 26号, 2017
  20. Activated full-length myosin-X moves processively on filopodia with large steps toward diverse two-dimensional directions., Scientific reports, 7巻, 2017
  21. Design and development of genetically encoded fluorescent sensors to monitor intracellular chemical and physical parameters., Biophysical reviews, 8巻, 2号, 2016
  22. Simultaneous nano-tracking of multiple motor proteins via spectral discrimination of quantum dots., Biomedical optics express, 7巻, 7号, 2016
  23. Full control of polarization state with a pair of electro-optic modulators for polarization-resolved optical microscopy: erratum., Applied optics, 55巻, 15号, 2016
  24. Dependence of fluorescent protein brightness on protein concentration in solution and enhancement of it., Scientific reports, 6巻, 2016
  25. Full control of polarization state with a pair of electro-optic modulators for polarization-resolved optical microscopy., Applied optics, 55巻, 5号, 2016
  26. Non-label immune cell state prediction using Raman spectroscopy., Scientific reports, 6巻, 2016
  27. Predictive diagnosis of the risk of breast cancer recurrence after surgery by single-particle quantum dot imaging., Scientific reports, 5巻, 2015
  28. SH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane., The FEBS journal, 282巻, 20号, 2015
  29. Visualizing the appearance and disappearance of the attractor of differentiation using Raman spectral imaging., Scientific reports, 5巻, 2015
  30. Expanded palette of Nano-lanterns for real-time multicolor luminescence imaging., Proceedings of the National Academy of Sciences of the United States of America, 112巻, 14号, 2015
  31. Gene dynamics of core transcription factors for pluripotency in embryonic stem cells., Journal of bioscience and bioengineering, 119巻, 4号, 2015
  32. Nano-scale measurement of biomolecules by optical microscopy and semiconductor nanoparticles., Frontiers in physiology, 5巻, 2014
  33. Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis., Cell, 157巻, 3号, 2014
  34. Visualizing cell state transition using Raman spectroscopy., PloS one, 9巻, 1号, 2014
  35. Culturing of mouse and human cells on soft substrates promote the expression of stem cell markers., Journal of bioscience and bioengineering, 117巻, 6号, 2014
  36. Glycine insertion makes yellow fluorescent protein sensitive to hydrostatic pressure., PloS one, 8巻, 8号, 2013
  37. Four-dimensional spatial nanometry of single particles in living cells using polarized quantum rods., Biophysical journal, 105巻, 3号, 2013
  38. Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement., Nature communications, 4巻, 2013
  39. Improving spinning disk confocal microscopy by preventing pinhole cross-talk for intravital imaging., Proceedings of the National Academy of Sciences of the United States of America, 110巻, 9号, 2013
  40. Distinct modulated pupil function system for real-time imaging of living cells., PloS one, 7巻, 9号, 2012
  41. Multilayered, core/shell nanoprobes based on magnetic ferric oxide particles and quantum dots for multimodality imaging of breast cancer tumors., Biomaterials, 33巻, 33号, 2012
  42. Atg9 vesicles are an important membrane source during early steps of autophagosome formation., The Journal of cell biology, 198巻, 2号, 2012
  43. Engineering strain-sensitive yellow fluorescent protein., Chemical communications (Cambridge, England), 48巻, 63号, 2012
  44. Chromatin plasticity as a differentiation index during muscle differentiation of C2C12 myoblasts., Biochemical and biophysical research communications, 418巻, 4号, 2012
  45. Real-time nanoscopy by using blinking enhanced quantum dots., Biophysical journal, 99巻, 7号, 2010
  46. Antibody-protein A conjugated quantum dots for multiplexed imaging of surface receptors in living cells., Molecular bioSystems, 6巻, 11号, 2010
  47. Mechanical characterization of one-headed myosin-V using optical tweezers., PloS one, 5巻, 8号, 2010
  48. Identification of three distinct functional sites of insulin-mediated GLUT4 trafficking in adipocytes using quantitative single molecule imaging., Molecular biology of the cell, 21巻, 15号, 2010
  49. Single molecular observation of self-regulated kinesin motility., Biochemistry, 49巻, 22号, 2010
  50. Myosin-X induces filopodia by multiple elongation mechanism., The Journal of biological chemistry, 285巻, 25号, 2010
  51. In vivo nano-imaging of membrane dynamics in metastatic tumor cells using quantum dots., The Journal of biological chemistry, 285巻, 4号, 2010
  52. Synthesis and Characterization of Anti-HER2 Antibody Conjugated CdSe/CdZnS Quantum Dots for Fluorescence Imaging of Breast Cancer Cells., Sensors (Basel, Switzerland), 9巻, 11号, 2009
  53. Human myosin Vc is a low duty ratio nonprocessive motor., The Journal of biological chemistry, 283巻, 16号, 2008
  54. In vivo real-time tracking of single quantum dots conjugated with monoclonal anti-HER2 antibody in tumors of mice., Cancer research, 67巻, 3号, 2007
  55. Three-dimensional nanometry of vesicle transport in living cells using dual-focus imaging optics., Biochemical and biophysical research communications, 359巻, 1号, 2007
  56. Stepwise movements in vesicle transport of HER2 by motor proteins in living cells., Biophysical journal, 92巻, 11号, 2007
  57. Input-output relationship in galvanotactic response of Dictyostelium cells., Bio Systems, 88巻, 3号, 2007
  58. Reduction in nonfluorescence state of quantum dots on an immunofluorescence staining., Biochemical and biophysical research communications, 351巻, 1号, 2006
  59. Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein., Proceedings of the National Academy of Sciences of the United States of America, 103巻, 15号, 2006
  60. Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein., Journal of cell science, 119巻, Pt 6号, 2006
  61. A one-headed class V myosin molecule develops multiple large (approximately 32-nm) steps successively., Proceedings of the National Academy of Sciences of the United States of America, 101巻, 26号, 2004
  62. Single- and multiple-molecule dynamics of the signaling from H-Ras to cRaf-1 visualized on the plasma membrane of living cells., Chemphyschem : a European journal of chemical physics and physical chemistry, 4巻, 7号, 2003