藤田 英明HIDEAKI FUJITA
Last Updated :2026/09/02
- 所属・職名
- 原爆放射線医科学研究所 准教授
- メールアドレス
- fujitah
hiroshima-u.ac.jp
基本情報
学位
- 博士（理学） (早稲田大学)
- 修士（理学） (早稲田大学)
教育活動
授業担当
- 2026年, 教養教育, ２ターム, 初修物理学[1医,1歯歯,1歯工,1薬]
- 2026年, 教養教育, １ターム, 初修生物学[1医,1歯,1薬]
- 2026年, 学部専門, 集中, 医学研究実習
- 2026年, 博士課程・博士課程後期, セメスター（前期）, 幹細胞機能学特別演習
- 2026年, 博士課程・博士課程後期, セメスター（後期）, 幹細胞機能学特別演習
- 2026年, 博士課程・博士課程後期, セメスター（後期）, 放射線生物学入門
研究活動
学術論文（★は代表的な論文）
- Investigation of post-irradiation molecular changes in LiPCDA-based radiochromic film (Gafchromic EBT4) using Raman spectroscopy, BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, 12巻, 3号, 20260601
- Fetal bovine serum concentration-dependent differentiation of multi-layered myoblasts, Journal of Bioscience and Bioengineering, 141巻, 6号, pp. 450-455, 20260306
- Characteristics of human induced pluripotent stem cells cultured on soft substrates, CYTOTECHNOLOGY, 78巻, 1号, 20260131
- Raman spectroscopy investigation of age-related radiation effects on fingernail molecular structure for individual-based ESR dosimetry, RADIATION MEASUREMENTS, 192巻, 202603
- Comparative analysis of autofluorescence spectra in a filet of three fish species during chilled storage for raw consumption, FOOD CHEMISTRY, 493巻, 20251130
- Dynamic Remodeling of Mechano-Sensing Complexes in Suspended Fibroblast Cell-Sheets Under External Mechanical Stimulus, Biotechnology and Bioengineering, 122巻, 7号, pp. 1929-1940, 202507
- Optical evaluation of internal meat quality deterioration in a tuna fillet based on second-harmonic generation anisotropy measurement, JOURNAL OF FOOD ENGINEERING, 391巻, 202505
- Bone morphogenetic protein signaling inhibitor improves differentiation and function of 3D muscle construct fabricated using C2C12, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 137巻, 6号, pp. 480-486, 202406
- Yuragi biomarker concept for evaluating human induced pluripotent stem cells using heterogeneity-based Raman finger-printing, BIOPHYSICS AND PHYSICOBIOLOGY, 21巻, 2024
- Single-molecule tracking of Nanog and Oct4 in living mouse embryonic stem cells uncovers a feedback mechanism of pluripotency maintenance, EMBO JOURNAL, 42巻, 18号, 20230918
- Estimation of crossbridge-state during cardiomyocyte beating using second harmonic generation, LIFE SCIENCE ALLIANCE, 6巻, 8号, 202308
- Application of the Dynamical Network Biomarker Theory to Raman Spectra, BIOMOLECULES, 12巻, 12号, 202212
- Microarray profiling of gene expression in C2C12 myotubes trained by electric pulse stimulation, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 132巻, 4号, pp. 417-422, 202110
- Pressure-induced changes on the morphology and gene expression in mammalian cells, BIOLOGY OPEN, 10巻, 7号, 202107
- Effect of hydrogen peroxide concentration on the maintenance and differentiation of cultured skeletal muscle cells, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 131巻, 5号, pp. 572-578, 202105
- Activation probability of a single naive T cell upon TCR ligation is controlled by T cells interacting with the same antigen-presenting cell, FEBS LETTERS, 595巻, 11号, pp. 1512-1524, 202106
- Glycine insertion modulates the fluorescence properties of Aequorea victoria green fluorescent protein and its variants in their ambient environment, BIOPHYSICS AND PHYSICOBIOLOGY, 18巻, pp. 145-158, 2021
- Effect of cell-extracellular matrix interaction on myogenic characteristics and artificial skeletal muscle tissue, Journal of Bioscience and Bioengineering, 130巻, 1号, pp. 98-105, 2020
- Linking substrate and nucleus via actin cytoskeleton in pluripotency maintenance of mouse embryonic stem cells, Stem cell research, 41巻, pp. 101614, 2019
- Eurotium cristatum fermented okara as a potential food ingredient to combat diabetes, Scientific reports, 9巻, 1号, pp. 1-9, 2019
- Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance, International immunology, 31巻, 11号, pp. 743-753, 2019
- Single cell analysis reveals a biophysical aspect of collective cell-state transition in embryonic stem cell differentiation, Scientific reports, 8巻, 1号, pp. 1-13, 2018
- Cell type discrimination based on image features of molecular component distribution, Scientific reports, 8巻, 1号, pp. 1-8, 2018
- Raman spectral signature reflects transcriptomic features of antibiotic resistance in escherichia coli, Communications biology, 1巻, 1号, pp. 1-10, 2018
- Substrate rigidity-dependent positive feedback regulation between YAP and ROCK2, Cell adhesion & migration, 12巻, 2号, pp. 101-108, 2018
- Design and fabrication of devices for investigating cell-sheet stretch, BioChip Journal, 11巻, 3号, pp. 173-179, 2017
- A novel c‐Src recruitment pathway from the cytosol to focal adhesions, FEBS letters, 591巻, 13号, pp. 1940-1946, 2017
- Raman spectroscopy as a tool for ecology and evolution, Journal of The Royal Society Interface, 14巻, 131号, pp. 20170174, 2017
- Protein expression guided chemical profiling of living cells by the simultaneous observation of Raman scattering and anti-Stokes fluorescence emission, Scientific reports, 7巻, pp. 43569, 2017
- The use of a genetically encoded molecular crowding sensor in various biological phenomena, Biophysics and Physicobiology, 14巻, pp. 119-125, 2017
- Substrate stiffness influences doxorubicin-induced p53 activation via ROCK2 expression, BioMed Research International, 2017巻, 1号, pp. 5158961, 2017
- Non-label immune cell state prediction using Raman spectroscopy, Scientific reports, 6巻, 37562号, 2016
- Simultaneous nano-tracking of multiple motor proteins via spectral discrimination of quantum dots, Biomedical optics express, 7巻, 7号, pp. 2475-2493, 2016
- Dependence of fluorescent protein brightness on protein concentration in solution and enhancement of it, Scientific reports, 6巻, pp. 22342, 2016
- Full control of polarization state with a pair of electro-optic modulators for polarization-resolved optical microscopy, Applied optics, 55巻, 5号, pp. 1082-1089, 2016
- SH 3 domain of c‐Src governs its dynamics at focal adhesions and the cell membrane, The FEBS journal, 282巻, 20号, pp. 4034-4055, 2015
- Visualizing the appearance and disappearance of the attractor of differentiation using Raman spectral imaging, Scientific reports, 5巻, 11358号, 2015
- Particle simulation of oxidation induced band 3 clustering in human erythrocytes, PLoS Comput Biol, 11巻, 6号, pp. e1004210, 2015
- Fluid driving system for a micropump by differentiating iPS cells into cardiomyocytes on a tent-like structure, Sensors and Actuators B: Chemical, 210巻, pp. 267-272, 2015
- Gene dynamics of core transcription factors for pluripotency in embryonic stem cells, Journal of bioscience and bioengineering, 119巻, 4号, pp. 406-409, 2015
- Comprehensive chemical secretory measurement of single cells trapped in a micro-droplet array with mass spectrometry, RSC advances, 5巻, 22号, pp. 16968-16971, 2015
- Displacement of p130Cas from focal adhesions links actomyosin contraction to cell migration, Journal of cell science, 127巻, 16号, pp. 3440-3450, 2014
- Culturing of mouse and human cells on soft substrates promote the expression of stem cell markers, Journal of bioscience and bioengineering, 117巻, 6号, pp. 749-755, 2014
- Induction of functional tissue-engineered skeletal muscle constructs by defined electrical stimulation, Scientific reports, 4巻, pp. 4781, 2014
- Visualizing cell state transition using Raman spectroscopy, PLoS One, 9巻, 1号, pp. e84478, 2014
- Metabolic flux analysis of genetically engineered Saccharomyces cerevisiae that produces lactate under micro-aerobic conditions, Bioprocess and biosystems engineering, 36巻, 9号, pp. 1261-1265, 2013
- Glycine insertion makes yellow fluorescent protein sensitive to hydrostatic pressure, PLoS One, 8巻, 8号, pp. e73212, 2013
- Four-dimensional spatial nanometry of single particles in living cells using polarized quantum rods, Biophysical journal, 105巻, 3号, pp. 555-564, 2013
- Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells, Journal of bioscience and bioengineering, 115巻, 3号, pp. 320-325, 2013
- Fed-batch system for cultivating genetically engineered yeast that produces lactic acid via the fermentative promoter, Journal of bioscience and bioengineering, 115巻, 2号, pp. 193-195, 2013
- Distinct Modulated Pupil Function System for Real-Time Imaging of Living Cells, Plos one, 7巻, 9号, pp. e44028, 2012
- p130Cas-dependent actin remodelling regulates myogenic differentiation, Biochemical Journal, 445巻, 3号, pp. 323-332, 2012
- Chromatin plasticity as a differentiation index during muscle differentiation of C2C12 myoblasts, Biochemical and biophysical research communications, 418巻, 4号, pp. 742-747, 2012
- Engineering strain-sensitive yellow fluorescent protein, Chemical Communications, 48巻, 63号, pp. 7871-7873, 2012
- Designing of a Si-MEMS device with an integrated skeletal muscle cell-based bio-actuator, Biomedical microdevices, 13巻, 1号, pp. 123-129, 2011
- Functional evaluation of artificial skeletal muscle tissue constructs fabricated by a magnetic force-based tissue engineering technique, Tissue Engineering Part A, 17巻, 1-2号, pp. 107-114, 2011
- Rapid decrease in active tension generated by C2C12 myotubes after termination of artificial exercise, Journal of muscle research and cell motility, 31巻, 4号, pp. 279-288, 2010
- Evaluation of serum‐free differentiation conditions for C2C12 myoblast cells assessed as to active tension generation capability, Biotechnology and bioengineering, 107巻, 5号, pp. 894-901, 2010
- Enhancement of C2C12 differentiation by perfluorocarbon-mediated oxygen delivery, Journal of bioscience and bioengineering, 110巻, 3号, pp. 359-362, 2010
- Fabrication of scaffold‐free contractile skeletal muscle tissue using magnetite‐incorporated myogenic C2C12 cells, Journal of tissue engineering and regenerative medicine, 4巻, 6号, pp. 437-443, 2010
- Identification of three distinct functional sites of insulin-mediated GLUT4 trafficking in adipocytes using quantitative single molecule imaging, Molecular biology of the cell, 21巻, 15号, pp. 2721-2731, 2010
- Novel method for measuring active tension generation by C2C12 myotube using UV‐crosslinked collagen film, Biotechnology and bioengineering, 106巻, 3号, pp. 482-489, 2010
- Oxygen plasma‐treated thermoresponsive polymer surfaces for cell sheet engineering, Biotechnology and bioengineering, 106巻, 2号, pp. 303-310, 2010
- Assembly of skeletal muscle cells on a Si-MEMS device and their generative force measurement, Biomedical microdevices, 12巻, 2号, pp. 247-252, 2010
- Micropatterning of single myotubes on a thermoresponsive culture surface using elastic stencil membranes for single-cell analysis, Journal of bioscience and bioengineering, 109巻, 2号, pp. 174-178, 2010
- Preparation of artificial skeletal muscle tissues by a magnetic force-based tissue engineering technique, Journal of bioscience and bioengineering, 108巻, 6号, pp. 538-543, 2009
- Novel method for fabrication of skeletal muscle construct from the C2C12 myoblast cell line using serum‐free medium AIM‐V, Biotechnology and bioengineering, 103巻, 5号, pp. 1034-1041, 2009
- Alignment of skeletal muscle myoblasts and myotubes using linear micropatterned surfaces ground with abrasives, Biotechnology and bioengineering, 103巻, 3号, pp. 631-638, 2009
- Application of a cell sheet–polymer film complex with temperature sensitivity for increased mechanical strength and cell alignment capability, Biotechnology and bioengineering, 103巻, 2号, pp. 370-377, 2009
- Contractile C2C12 myotube model for studying exercise-inducible responses in skeletal muscle, American Journal of Physiology-Endocrinology and Metabolism, 295巻, 5号, pp. E1191-E1204, 2008
- Accelerated de novo sarcomere assembly by electric pulse stimulation in C2C12 myotubes, Experimental cell research, 313巻, 9号, pp. 1853-1865, 2007
- A new muscle contractile system composed of a thick filament lattice and a single actin filament, Biophysical journal, 89巻, 1号, pp. 321-328, 2005
- Auto-oscillations of skinned myocardium correlating with heartbeat, Journal of Muscle Research & Cell Motility, 26巻, 2-3号, pp. 93-101, 2005
- Titin isoform-dependent effect of calcium on passive myocardial tension, American Journal of Physiology-Heart and Circulatory Physiology, 287巻, 6号, pp. H2528-H2534, 2004
- The effect of tropomyosin on force and elementary steps of the cross‐bridge cycle in reconstituted bovine myocardium, The Journal of Physiology, 556巻, 2号, pp. 637-649, 2004
- Calcium-dependent molecular spring elements in the giant protein titin, Proceedings of the National Academy of Sciences, 100巻, 23号, pp. 13716-13721, 2003
- The length of cooperative units on the thin filament in rabbit psoas muscle fibres, Experimental physiology, 87巻, 6号, pp. 691-697, 2002
- Myosin light chain 2 modulates MgADP‐induced contraction in rabbit skeletal and bovine cardiac skinned muscle, The Journal of physiology, 542巻, 1号, pp. 221-229, 2002
- Temperature effect on isometric tension is mediated by regulatory proteins tropomyosin and troponin in bovine myocardium, The Journal of Physiology, 539巻, 1号, pp. 267-276, 2002
- Elementary steps of the cross-bridge cycle in bovine myocardium with and without regulatory proteins, Biophysical Journal, 82巻, 2号, pp. 915-928, 2002
- Tropomyosin modulates pH dependence of isometric tension, Biophysical journal, 77巻, 3号, pp. 1540-1546, 1999
- Regulatory roles of MgADP and calcium in tension development of skinned cardiac muscle, Journal of Muscle Research & Cell Motility, 19巻, 8号, pp. 909-921, 1998
- Spontaneous oscillatory contraction without regulatory proteins in actin filament-reconstituted fibers, Biophysical journal, 75巻, 3号, pp. 1439-1445, 1998
- Spontaneous tension oscillation in skinned bovine cardiac muscle, Pflügers Archiv, 433巻, 1-2号, pp. 1-8, 1996
- Structural and functional reconstitution of thin filaments in the contractile apparatus of cardiac muscle, Biophysical journal, 71巻, 5号, pp. 2307-2318, 1996
著書等出版物
- Use of optical techniques to evaluate the ionizing radiation effects on biological specimens, Journal of Radiation Research, 2024年, 65 (Supple_1): i117-i125.
- Recent Advances in Raman Spectral Imaging in Cell Diagnosis and Gene Expression Prediction, Genes, 2022年, 13(11): 2127.
- Recent advances in animal cell technologies for industrial and medical applications, J. Biosci. Bioeng., 2022年, 133(6): 509-514.
- Bright dots and smart optical microscopy to probe intracellular events in single cells, Front. Bioeng. Biotech., 2019年, 6: 204.
- Design and development of genetically encoded fluorescent sensors to monitor intracellular chemical and physical parameters, Biophys. Rev., 2016年, 8: 121-138.
- Nano-scale measurement of biomolecules by optical microscopy and semiconductor nanoparticles., Front. Physiol., 2014年, 5: 273.
- Evaluation systems of generated forces of skeletal muscle cell-based bio-actuators., J. Biosci. Bioeng., 2013年, 115(2): 115-21.
- Thin filament-reconstituted skinned muscle fibers for the study of muscle physiology., J. Biomed. Biotechnol., 2011年, 2011:486021: 1-7.
- Fabrication of Skeletal Muscle Tissue from C2C12 Myoblast Cell Towards the Use as Bio-Actuator., Animal Cell Technology: Basic & Applied Aspects, 2010年, 16: 177-183.
- Integration of skeletal muscle cell onto Si-MEMS and its generative force measurement, Proceedings of IEEE MEMS 2009., 2009年, 403-406.
- Bio-nanomuscle project: Contractile properties of single actin filaments in an A-band motility assay system., Adv. Exp. Med. & Biol.,, 2003年, 538: 103-109.
- Contractile properties of thin (actin) filament-reconstituted muscle fibers., Adv. Exp. Med. & Biol.,, 1998年, 453: 319-328.
- Microscopic analysis of the elastic properties of connectin/titin and nebulin in Myofibrils., Adv. Biophys.,, 1996年, 33: 135-142.
- Progress of Endogenous and Exogenous Nanoparticles for Cancer Therapy and Diagnostics., Genes, 2023年, 14(2): 259., Fujita H., Ohta S., Nakamura N., Somiya M., Horie M.
- Length regulation of thin filaments without nebulin., Proc. Japan Acad.,, 1994年, 70 Ser.B: 151-156.
社会活動
学術会議等の主催
- 第１回シンギュラリティー生物学×放射線医科学研究会, 2310年06月, 2310年06月
- 第4回骨格筋スマート社会実現コンソーシアム講演会, オーガナイザー, 2021年09月, 2021年09月
- 2021 国際大学連携動物細胞研究会, 大会実行委員長, 2021年09月, 2021年09月
- 第42回動物細胞工学会2021年度大会, 大会実行委員, 2021年07月, 2021年07月
- 2021シンギュラリティ生物学Web交流会, オーガナイザー, 2021年04月, 2022年03月
- 化学工学会第52会春季大会バイオ部会シンポジウム, オーガナイザー, 2021年09月, 2021年09月
- 2022シンギュラリティ生物学Web交流会, オーガナイザー, 2022年04月, 2023年03月
- 第5回骨格筋スマート社会実現コンソーシアム講演会, オーガナイザー, 2022年11月, 2022年11月
