藤田 英明HIDEAKI FUJITA

Last Updated :2021/04/05

所属・職名
原爆放射線医科学研究所 助教
メールアドレス
fujitahhiroshima-u.ac.jp

基本情報

学位

  • 博士(理学) (早稲田大学)
  • 修士(理学) (早稲田大学)

研究活動

学術論文(★は代表的な論文)

  1. Effect of cell-extracellular matrix interaction on myogenic characteristics and artificial skeletal muscle tissue, Journal of Bioscience and Bioengineering, 130巻, 1号, pp. 98-105, 2020
  2. Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance, International immunology, 31巻, 11号, pp. 743-753, 2019
  3. Eurotium cristatum fermented okara as a potential food ingredient to combat diabetes, Scientific reports, 9巻, 1号, pp. 1-9, 2019
  4. Linking substrate and nucleus via actin cytoskeleton in pluripotency maintenance of mouse embryonic stem cells, Stem cell research, 41巻, pp. 101614, 2019
  5. Substrate rigidity-dependent positive feedback regulation between YAP and ROCK2, Cell adhesion & migration, 12巻, 2号, pp. 101-108, 2018
  6. Raman spectral signature reflects transcriptomic features of antibiotic resistance in escherichia coli, Communications biology, 1巻, 1号, pp. 1-10, 2018
  7. Cell type discrimination based on image features of molecular component distribution, Scientific reports, 8巻, 1号, pp. 1-8, 2018
  8. Single cell analysis reveals a biophysical aspect of collective cell-state transition in embryonic stem cell differentiation, Scientific reports, 8巻, 1号, pp. 1-13, 2018
  9. The use of a genetically encoded molecular crowding sensor in various biological phenomena, Biophysics and Physicobiology, 14巻, pp. 119-125, 2017
  10. Substrate stiffness influences doxorubicin-induced p53 activation via ROCK2 expression, BioMed Research International, 2017巻, 2017
  11. Protein expression guided chemical profiling of living cells by the simultaneous observation of Raman scattering and anti-Stokes fluorescence emission, Scientific reports, 7巻, pp. 43569, 2017
  12. Raman spectroscopy as a tool for ecology and evolution, Journal of The Royal Society Interface, 14巻, 131号, pp. 20170174, 2017
  13. Design and fabrication of devices for investigating cell-sheet stretch, BioChip Journal, 11巻, 3号, pp. 173-179, 2017
  14. A novel c‐Src recruitment pathway from the cytosol to focal adhesions, Febs Letters, 591巻, 13号, pp. 1940-1946, 2017
  15. Full control of polarization state with a pair of electro-optic modulators for polarization-resolved optical microscopy, Applied optics, 55巻, 5号, pp. 1082-1089, 2016
  16. Dependence of fluorescent protein brightness on protein concentration in solution and enhancement of it, Scientific reports, 6巻, pp. 22342, 2016
  17. Simultaneous nano-tracking of multiple motor proteins via spectral discrimination of quantum dots, Biomedical optics express, 7巻, 7号, pp. 2475-2493, 2016
  18. Non-label immune cell state prediction using Raman spectroscopy, Scientific reports, 6巻, 37562号, 2016
  19. Comprehensive chemical secretory measurement of single cells trapped in a micro-droplet array with mass spectrometry, RSC advances, 5巻, 22号, pp. 16968-16971, 2015
  20. Gene dynamics of core transcription factors for pluripotency in embryonic stem cells, Journal of bioscience and bioengineering, 119巻, 4号, pp. 406-409, 2015
  21. Fluid driving system for a micropump by differentiating iPS cells into cardiomyocytes on a tent-like structure, Sensors and Actuators B: Chemical, 210巻, pp. 267-272, 2015
  22. Particle simulation of oxidation induced band 3 clustering in human erythrocytes, PLoS Comput Biol, 11巻, 6号, pp. e1004210, 2015
  23. SH 3 domain of c‐Src governs its dynamics at focal adhesions and the cell membrane, The FEBS journal, 282巻, 20号, pp. 4034-4055, 2015
  24. Visualizing the appearance and disappearance of the attractor of differentiation using Raman spectral imaging, Scientific reports, 5巻, 11358号, 2015
  25. Visualizing cell state transition using Raman spectroscopy, PLoS One, 9巻, 1号, pp. e84478, 2014
  26. Induction of functional tissue-engineered skeletal muscle constructs by defined electrical stimulation, Scientific reports, 4巻, pp. 4781, 2014
  27. Culturing of mouse and human cells on soft substrates promote the expression of stem cell markers, Journal of bioscience and bioengineering, 117巻, 6号, pp. 749-755, 2014
  28. Displacement of p130Cas from focal adhesions links actomyosin contraction to cell migration, Journal of cell science, 127巻, 16号, pp. 3440-3450, 2014
  29. Evaluation systems of generated forces of skeletal muscle cell-based bio-actuators, Journal of bioscience and bioengineering, 115巻, 2号, pp. 115-121, 2013
  30. Fed-batch system for cultivating genetically engineered yeast that produces lactic acid via the fermentative promoter, Journal of bioscience and bioengineering, 115巻, 2号, pp. 193-195, 2013
  31. Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells, Journal of bioscience and bioengineering, 115巻, 3号, pp. 320-325, 2013
  32. Four-dimensional spatial nanometry of single particles in living cells using polarized quantum rods, Biophysical journal, 105巻, 3号, pp. 555-564, 2013
  33. Glycine insertion makes yellow fluorescent protein sensitive to hydrostatic pressure, PLoS One, 8巻, 8号, pp. e73212, 2013
  34. Metabolic flux analysis of genetically engineered Saccharomyces cerevisiae that produces lactate under micro-aerobic conditions, Bioprocess and biosystems engineering, 36巻, 9号, pp. 1261-1265, 2013
  35. Engineering strain-sensitive yellow fluorescent protein, Chemical Communications, 48巻, 63号, pp. 7871-7873, 2012
  36. Chromatin plasticity as a differentiation index during muscle differentiation of C2C12 myoblasts, Biochemical and biophysical research communications, 418巻, 4号, pp. 742-747, 2012
  37. p130Cas-dependent actin remodelling regulates myogenic differentiation, Biochemical Journal, 445巻, 3号, pp. 323-332, 2012
  38. Distinct Modulated Pupil Function System for Real-Time Imaging of Living Cells, Plos one, 7巻, 9号, pp. e44028, 2012
  39. Functional evaluation of artificial skeletal muscle tissue constructs fabricated by a magnetic force-based tissue engineering technique, Tissue Engineering Part A, 17巻, 1-2号, pp. 107-114, 2011
  40. Thin filament-reconstituted skinned muscle fibers for the study of muscle physiology, Journal of Biomedicine and Biotechnology, 2011巻, 2011
  41. Designing of a Si-MEMS device with an integrated skeletal muscle cell-based bio-actuator, Biomedical microdevices, 13巻, 1号, pp. 123-129, 2011
  42. Magnetic force-based tissue engineering of skeletal muscle, Journal of Biotechnology, 150巻, pp. 441, 2010
  43. Micropatterning of single myotubes on a thermoresponsive culture surface using elastic stencil membranes for single-cell analysis, Journal of bioscience and bioengineering, 109巻, 2号, pp. 174-178, 2010
  44. Assembly of skeletal muscle cells on a Si-MEMS device and their generative force measurement, Biomedical microdevices, 12巻, 2号, pp. 247-252, 2010
  45. Oxygen plasma‐treated thermoresponsive polymer surfaces for cell sheet engineering, Biotechnology and bioengineering, 106巻, 2号, pp. 303-310, 2010
  46. Novel method for measuring active tension generation by C2C12 myotube using UV‐crosslinked collagen film, Biotechnology and bioengineering, 106巻, 3号, pp. 482-489, 2010
  47. Identification of three distinct functional sites of insulin-mediated GLUT4 trafficking in adipocytes using quantitative single molecule imaging, Molecular biology of the cell, 21巻, 15号, pp. 2721-2731, 2010
  48. Fabrication of scaffold‐free contractile skeletal muscle tissue using magnetite‐incorporated myogenic C2C12 cells, Journal of tissue engineering and regenerative medicine, 4巻, 6号, pp. 437-443, 2010
  49. Enhancement of C2C12 differentiation by perfluorocarbon-mediated oxygen delivery, Journal of bioscience and bioengineering, 110巻, 3号, pp. 359-362, 2010
  50. Evaluation of serum‐free differentiation conditions for C2C12 myoblast cells assessed as to active tension generation capability, Biotechnology and bioengineering, 107巻, 5号, pp. 894-901, 2010
  51. Rapid decrease in active tension generated by C2C12 myotubes after termination of artificial exercise, Journal of muscle research and cell motility, 31巻, 4号, pp. 279-288, 2010
  52. Application of a cell sheet–polymer film complex with temperature sensitivity for increased mechanical strength and cell alignment capability, Biotechnology and bioengineering, 103巻, 2号, pp. 370-377, 2009
  53. Alignment of skeletal muscle myoblasts and myotubes using linear micropatterned surfaces ground with abrasives, Biotechnology and bioengineering, 103巻, 3号, pp. 631-638, 2009
  54. Novel method for fabrication of skeletal muscle construct from the C2C12 myoblast cell line using serum‐free medium AIM‐V, Biotechnology and bioengineering, 103巻, 5号, pp. 1034-1041, 2009
  55. Preparation of artificial skeletal muscle tissues by a magnetic force-based tissue engineering technique, Journal of bioscience and bioengineering, 108巻, 6号, pp. 538-543, 2009
  56. Contractile C2C12 myotube model for studying exercise-inducible responses in skeletal muscle, American Journal of Physiology-Endocrinology and Metabolism, 295巻, 5号, pp. E1191-E1204, 2008
  57. Accelerated de novo sarcomere assembly by electric pulse stimulation in C2C12 myotubes, Experimental cell research, 313巻, 9号, pp. 1853-1865, 2007
  58. Auto-oscillations of skinned myocardium correlating with heartbeat, Journal of Muscle Research & Cell Motility, 26巻, 2-3号, pp. 93-101, 2005
  59. A new muscle contractile system composed of a thick filament lattice and a single actin filament, Biophysical journal, 89巻, 1号, pp. 321-328, 2005
  60. The effect of tropomyosin on force and elementary steps of the cross‐bridge cycle in reconstituted bovine myocardium, The Journal of Physiology, 556巻, 2号, pp. 637-649, 2004
  61. Titin isoform-dependent effect of calcium on passive myocardial tension, American Journal of Physiology-Heart and Circulatory Physiology, 287巻, 6号, pp. H2528-H2534, 2004
  62. Calcium-dependent molecular spring elements in the giant protein titin, Proceedings of the National Academy of Sciences, 100巻, 23号, pp. 13716-13721, 2003
  63. Elementary steps of the cross-bridge cycle in bovine myocardium with and without regulatory proteins, Biophysical Journal, 82巻, 2号, pp. 915-928, 2002
  64. Temperature effect on isometric tension is mediated by regulatory proteins tropomyosin and troponin in bovine myocardium, The Journal of Physiology, 539巻, 1号, pp. 267-276, 2002
  65. Myosin light chain 2 modulates MgADP‐induced contraction in rabbit skeletal and bovine cardiac skinned muscle, The Journal of physiology, 542巻, 1号, pp. 221-229, 2002
  66. The length of cooperative units on the thin filament in rabbit psoas muscle fibres, Experimental physiology, 87巻, 6号, pp. 691-697, 2002
  67. Tropomyosin modulates pH dependence of isometric tension, Biophysical journal, 77巻, 3号, pp. 1540-1546, 1999
  68. Spontaneous oscillatory contraction without regulatory proteins in actin filament-reconstituted fibers, Biophysical journal, 75巻, 3号, pp. 1439-1445, 1998
  69. Regulatory roles of MgADP and calcium in tension development of skinned cardiac muscle, Journal of Muscle Research & Cell Motility, 19巻, 8号, pp. 909-921, 1998
  70. Structural and functional reconstitution of thin filaments in the contractile apparatus of cardiac muscle, Biophysical journal, 71巻, 5号, pp. 2307-2318, 1996
  71. Spontaneous tension oscillation in skinned bovine cardiac muscle, Pflügers Archiv, 433巻, 1-2号, pp. 1-8, 1996