HIDEAKI FUJITA

Last Updated :2026/09/02

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Associate Professor
E-mail
fujitahhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Waseda University
  • Waseda University

Educational Activity

Course in Charge

  1. 2026, Liberal Arts Education Program1, 2Term, Foundation physics for life science
  2. 2026, Liberal Arts Education Program1, 1Term, Foundation biology for life science
  3. 2026, Undergraduate Education, Intensive, Practice for medical research
  4. 2026, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Stem Cell Biology
  5. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Stem Cell Biology
  6. 2026, Graduate Education (Doctoral Program) , Second Semester, Introduction to Radiation Biology

Research Activities

Academic Papers

  1. Investigation of post-irradiation molecular changes in LiPCDA-based radiochromic film (Gafchromic EBT4) using Raman spectroscopy, BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, 12(3), 20260601
    Link to Paper Search Results by DOI
  2. Fetal bovine serum concentration-dependent differentiation of multi-layered myoblasts, Journal of Bioscience and Bioengineering, 141(6), 450-455, 20260306
    Link to Paper Search Results by DOI
  3. Characteristics of human induced pluripotent stem cells cultured on soft substrates, CYTOTECHNOLOGY, 78(1), 20260131
    Link to Paper Search Results by DOI
  4. Raman spectroscopy investigation of age-related radiation effects on fingernail molecular structure for individual-based ESR dosimetry, RADIATION MEASUREMENTS, 192, 202603
    Link to Paper Search Results by DOI
  5. Comparative analysis of autofluorescence spectra in a filet of three fish species during chilled storage for raw consumption, FOOD CHEMISTRY, 493, 20251130
    Link to Paper Search Results by DOI
  6. Dynamic Remodeling of Mechano-Sensing Complexes in Suspended Fibroblast Cell-Sheets Under External Mechanical Stimulus, Biotechnology and Bioengineering, 122(7), 1929-1940, 202507
    Link to Paper Search Results by DOI
  7. Optical evaluation of internal meat quality deterioration in a tuna fillet based on second-harmonic generation anisotropy measurement, JOURNAL OF FOOD ENGINEERING, 391, 202505
    Link to Paper Search Results by DOI
  8. Bone morphogenetic protein signaling inhibitor improves differentiation and function of 3D muscle construct fabricated using C2C12, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 137(6), 480-486, 202406
    Link to Paper Search Results by DOI
  9. Yuragi biomarker concept for evaluating human induced pluripotent stem cells using heterogeneity-based Raman finger-printing, BIOPHYSICS AND PHYSICOBIOLOGY, 21, 2024
    Link to Paper Search Results by DOI
  10. Single-molecule tracking of Nanog and Oct4 in living mouse embryonic stem cells uncovers a feedback mechanism of pluripotency maintenance, EMBO JOURNAL, 42(18), 20230918
    Link to Paper Search Results by DOI
  11. Estimation of crossbridge-state during cardiomyocyte beating using second harmonic generation, LIFE SCIENCE ALLIANCE, 6(8), 202308
    Link to Paper Search Results by DOI
  12. Application of the Dynamical Network Biomarker Theory to Raman Spectra, BIOMOLECULES, 12(12), 202212
    Link to Paper Search Results by DOI
  13. Microarray profiling of gene expression in C2C12 myotubes trained by electric pulse stimulation, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 132(4), 417-422, 202110
    Link to Paper Search Results by DOI
  14. Pressure-induced changes on the morphology and gene expression in mammalian cells, BIOLOGY OPEN, 10(7), 202107
    Link to Paper Search Results by DOI
  15. Effect of hydrogen peroxide concentration on the maintenance and differentiation of cultured skeletal muscle cells, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 131(5), 572-578, 202105
    Link to Paper Search Results by DOI
  16. Activation probability of a single naive T cell upon TCR ligation is controlled by T cells interacting with the same antigen-presenting cell, FEBS LETTERS, 595(11), 1512-1524, 202106
    Link to Paper Search Results by DOI
  17. Glycine insertion modulates the fluorescence properties of Aequorea victoria green fluorescent protein and its variants in their ambient environment, BIOPHYSICS AND PHYSICOBIOLOGY, 18, 145-158, 2021
    Link to Paper Search Results by DOI
  18. Effect of cell-extracellular matrix interaction on myogenic characteristics and artificial skeletal muscle tissue, Journal of Bioscience and Bioengineering, 130(1), 98-105, 2020
    Link to Paper Search Results by DOI
  19. Linking substrate and nucleus via actin cytoskeleton in pluripotency maintenance of mouse embryonic stem cells, Stem cell research, 41, 101614, 2019
    Link to Paper Search Results by DOI
  20. Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance, International immunology, 31(11), 743-753, 2019
    Link to Paper Search Results by DOI
  21. Single cell analysis reveals a biophysical aspect of collective cell-state transition in embryonic stem cell differentiation, Scientific reports, 8(1), 1-13, 2018
    Link to Paper Search Results by DOI
  22. Cell type discrimination based on image features of molecular component distribution, Scientific reports, 8(1), 1-8, 2018
    Link to Paper Search Results by DOI
  23. Raman spectral signature reflects transcriptomic features of antibiotic resistance in escherichia coli, Communications biology, 1(1), 1-10, 2018
    Link to Paper Search Results by DOI
  24. Substrate rigidity-dependent positive feedback regulation between YAP and ROCK2, Cell adhesion & migration, 12(2), 101-108, 2018
    Link to Paper Search Results by DOI
  25. Design and fabrication of devices for investigating cell-sheet stretch, BioChip Journal, 11(3), 173-179, 2017
    Link to Paper Search Results by DOI
  26. A novel c‐Src recruitment pathway from the cytosol to focal adhesions, FEBS letters, 591(13), 1940-1946, 2017
    Link to Paper Search Results by DOI
  27. Protein expression guided chemical profiling of living cells by the simultaneous observation of Raman scattering and anti-Stokes fluorescence emission, Scientific reports, 7, 43569, 2017
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  28. The use of a genetically encoded molecular crowding sensor in various biological phenomena, Biophysics and Physicobiology, 14, 119-125, 2017
    Link to Paper Search Results by DOI
  29. Substrate stiffness influences doxorubicin-induced p53 activation via ROCK2 expression, BioMed Research International, 2017(1), 5158961, 2017
    Link to Paper Search Results by DOI
  30. Non-label immune cell state prediction using Raman spectroscopy, Scientific reports, 6(37562), 2016
    Link to Paper Search Results by DOI
  31. Simultaneous nano-tracking of multiple motor proteins via spectral discrimination of quantum dots, Biomedical optics express, 7(7), 2475-2493, 2016
    Link to Paper Search Results by DOI
  32. Dependence of fluorescent protein brightness on protein concentration in solution and enhancement of it, Scientific reports, 6, 22342, 2016
    Link to Paper Search Results by DOI
  33. Full control of polarization state with a pair of electro-optic modulators for polarization-resolved optical microscopy, Applied optics, 55(5), 1082-1089, 2016
    Link to Paper Search Results by DOI
  34. SH 3 domain of c‐Src governs its dynamics at focal adhesions and the cell membrane, The FEBS journal, 282(20), 4034-4055, 2015
    Link to Paper Search Results by DOI
  35. Visualizing the appearance and disappearance of the attractor of differentiation using Raman spectral imaging, Scientific reports, 5(11358), 2015
    Link to Paper Search Results by DOI
  36. Particle simulation of oxidation induced band 3 clustering in human erythrocytes, PLoS Comput Biol, 11(6), e1004210, 2015
    Link to Paper Search Results by DOI
  37. Fluid driving system for a micropump by differentiating iPS cells into cardiomyocytes on a tent-like structure, Sensors and Actuators B: Chemical, 210, 267-272, 2015
    Link to Paper Search Results by DOI
  38. Gene dynamics of core transcription factors for pluripotency in embryonic stem cells, Journal of bioscience and bioengineering, 119(4), 406-409, 2015
    Link to Paper Search Results by DOI
  39. Comprehensive chemical secretory measurement of single cells trapped in a micro-droplet array with mass spectrometry, RSC advances, 5(22), 16968-16971, 2015
    Link to Paper Search Results by DOI
  40. Displacement of p130Cas from focal adhesions links actomyosin contraction to cell migration, Journal of cell science, 127(16), 3440-3450, 2014
    Link to Paper Search Results by DOI
  41. Culturing of mouse and human cells on soft substrates promote the expression of stem cell markers, Journal of bioscience and bioengineering, 117(6), 749-755, 2014
    Link to Paper Search Results by DOI
  42. Induction of functional tissue-engineered skeletal muscle constructs by defined electrical stimulation, Scientific reports, 4, 4781, 2014
    Link to Paper Search Results by DOI
  43. Visualizing cell state transition using Raman spectroscopy, PLoS One, 9(1), e84478, 2014
    Link to Paper Search Results by DOI
  44. Metabolic flux analysis of genetically engineered Saccharomyces cerevisiae that produces lactate under micro-aerobic conditions, Bioprocess and biosystems engineering, 36(9), 1261-1265, 2013
    Link to Paper Search Results by DOI
  45. Glycine insertion makes yellow fluorescent protein sensitive to hydrostatic pressure, PLoS One, 8(8), e73212, 2013
    Link to Paper Search Results by DOI
  46. Four-dimensional spatial nanometry of single particles in living cells using polarized quantum rods, Biophysical journal, 105(3), 555-564, 2013
    Link to Paper Search Results by DOI
  47. Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells, Journal of bioscience and bioengineering, 115(3), 320-325, 2013
    Link to Paper Search Results by DOI
  48. Fed-batch system for cultivating genetically engineered yeast that produces lactic acid via the fermentative promoter, Journal of bioscience and bioengineering, 115(2), 193-195, 2013
    Link to Paper Search Results by DOI
  49. Distinct Modulated Pupil Function System for Real-Time Imaging of Living Cells, Plos one, 7(9), e44028, 2012
    Link to Paper Search Results by DOI
  50. p130Cas-dependent actin remodelling regulates myogenic differentiation, Biochemical Journal, 445(3), 323-332, 2012
    Link to Paper Search Results by DOI
  51. Chromatin plasticity as a differentiation index during muscle differentiation of C2C12 myoblasts, Biochemical and biophysical research communications, 418(4), 742-747, 2012
    Link to Paper Search Results by DOI
  52. The effect of tropomyosin on force and elementary steps of the cross‐bridge cycle in reconstituted bovine myocardium, The Journal of Physiology, 556(2), 637-649, 2004
    Link to Paper Search Results by DOI
  53. Calcium-dependent molecular spring elements in the giant protein titin, Proceedings of the National Academy of Sciences, 100(23), 13716-13721, 2003
    Link to Paper Search Results by DOI
  54. The length of cooperative units on the thin filament in rabbit psoas muscle fibres, Experimental physiology, 87(6), 691-697, 2002
    Link to Paper Search Results by DOI
  55. Myosin light chain 2 modulates MgADP‐induced contraction in rabbit skeletal and bovine cardiac skinned muscle, The Journal of physiology, 542(1), 221-229, 2002
    Link to Paper Search Results by DOI
  56. Temperature effect on isometric tension is mediated by regulatory proteins tropomyosin and troponin in bovine myocardium, The Journal of Physiology, 539(1), 267-276, 2002
    Link to Paper Search Results by DOI
  57. Elementary steps of the cross-bridge cycle in bovine myocardium with and without regulatory proteins, Biophysical Journal, 82(2), 915-928, 2002
    Link to Paper Search Results by DOI
  58. Tropomyosin modulates pH dependence of isometric tension, Biophysical journal, 77(3), 1540-1546, 1999
    Link to Paper Search Results by DOI
  59. Regulatory roles of MgADP and calcium in tension development of skinned cardiac muscle, Journal of Muscle Research & Cell Motility, 19(8), 909-921, 1998
    Link to Paper Search Results by DOI
  60. Spontaneous oscillatory contraction without regulatory proteins in actin filament-reconstituted fibers, Biophysical journal, 75(3), 1439-1445, 1998
    Link to Paper Search Results by DOI
  61. Spontaneous tension oscillation in skinned bovine cardiac muscle, Pflügers Archiv, 433(1-2), 1-8, 1996
    Link to Paper Search Results by DOI
  62. Structural and functional reconstitution of thin filaments in the contractile apparatus of cardiac muscle, Biophysical journal, 71(5), 2307-2318, 1996
    Link to Paper Search Results by DOI

Publications such as books

  1. Use of optical techniques to evaluate the ionizing radiation effects on biological specimens, Journal of Radiation Research, 2024, 65 (Supple_1): i117-i125.
  2. Recent Advances in Raman Spectral Imaging in Cell Diagnosis and Gene Expression Prediction, Genes, 2022, 13(11): 2127.
  3. Recent advances in animal cell technologies for industrial and medical applications, J. Biosci. Bioeng., 2022, 133(6): 509-514.
  4. Bright dots and smart optical microscopy to probe intracellular events in single cells, Front. Bioeng. Biotech., 2019, 6: 204.
  5. Design and development of genetically encoded fluorescent sensors to monitor intracellular chemical and physical parameters, Biophys. Rev., 2016, 8: 121-138.
  6. Nano-scale measurement of biomolecules by optical microscopy and semiconductor nanoparticles., Front. Physiol., 2014, 5: 273.
  7. Evaluation systems of generated forces of skeletal muscle cell-based bio-actuators., J. Biosci. Bioeng., 2013, 115(2): 115-21.
  8. Thin filament-reconstituted skinned muscle fibers for the study of muscle physiology., J. Biomed. Biotechnol., 2011, 2011:486021: 1-7.
  9. Fabrication of Skeletal Muscle Tissue from C2C12 Myoblast Cell Towards the Use as Bio-Actuator., Animal Cell Technology: Basic & Applied Aspects, 2010, 16: 177-183.
  10. Integration of skeletal muscle cell onto Si-MEMS and its generative force measurement, Proceedings of IEEE MEMS 2009., 2009, 403-406.
  11. Bio-nanomuscle project: Contractile properties of single actin filaments in an A-band motility assay system., Adv. Exp. Med. & Biol.,, 2003, 538: 103-109.
  12. Contractile properties of thin (actin) filament-reconstituted muscle fibers., Adv. Exp. Med. & Biol.,, 1998, 453: 319-328.
  13. Microscopic analysis of the elastic properties of connectin/titin and nebulin in Myofibrils., Adv. Biophys.,, 1996, 33: 135-142.
  14. Progress of Endogenous and Exogenous Nanoparticles for Cancer Therapy and Diagnostics., Genes, 2023, 14(2): 259., Fujita H., Ohta S., Nakamura N., Somiya M., Horie M.
  15. Length regulation of thin filaments without nebulin., Proc. Japan Acad.,, 1994, 70 Ser.B: 151-156.

Social Activities

Organizing Academic Conferences, etc.

  1. 2310/06, 2310/06
  2. 2021/09, 2021/09
  3. 2021 International Conference on Mammalian cell Biology, Executive committee, 2021/09, 2021/09
  4. 2021/07, 2021/07
  5. 2021/04, 2022/03
  6. 2021/09, 2021/09
  7. 2022/04, 2023/03
  8. 2022/11, 2022/11