服部 登NOBORU HATTORI

Last Updated :2021/01/05

所属・職名
大学院医系科学研究科(医) 教授
メールアドレス
nhattorihiroshima-u.ac.jp

基本情報

学位

  • 博士(医学) (京都大学)

研究分野

  • 医歯薬学 / 内科系臨床医学 / 呼吸器内科学

研究キーワード

  • 肺線維症
  • 胸部悪性腫瘍

教育活動

授業担当

  1. 2020年, 学部専門, 通年, 器官・システム病態制御学I
  2. 2020年, 学部専門, 集中, 医学研究実習
  3. 2020年, 学部専門, 集中, 臨床実習I
  4. 2020年, 学部専門, 集中, 臨床実習II
  5. 2020年, 教養教育, 1ターム, 教養ゼミ
  6. 2020年, 博士課程・博士課程後期, セメスター(前期), 分子内科学特別演習
  7. 2020年, 博士課程・博士課程後期, セメスター(後期), 分子内科学特別演習
  8. 2020年, 博士課程・博士課程後期, セメスター(前期), 分子内科学特別実験
  9. 2020年, 博士課程・博士課程後期, セメスター(後期), 分子内科学特別実験
  10. 2020年, 修士課程・博士課程前期, 3ターム, 予防医学・健康指導特論B
  11. 2020年, 博士課程・博士課程後期, セメスター(前期), 分子内科学特別演習
  12. 2020年, 博士課程・博士課程後期, セメスター(後期), 分子内科学特別演習
  13. 2020年, 博士課程・博士課程後期, セメスター(前期), 分子内科学特別研究
  14. 2020年, 博士課程・博士課程後期, セメスター(後期), 分子内科学特別研究

研究活動

学術論文(★は代表的な論文)

  1. Organizing pneumonia in a carrier of human T-cell lymphotropic virus type-1, ANNALS OF THORACIC MEDICINE, 15巻, 1号, pp. 41-43, 2020
  2. Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production, HYPERTENSION, 75巻, 2号, pp. 492-499, 202002
  3. Albumin-globulin ratio is a predictive biomarker of antitumor effect of anti-PD-1 antibody in patients with non-small cell lung cancer, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 25巻, 1号, pp. 74-81, 202001
  4. Prospective, randomized, cross-over pilot study of the effects of Rikkunshito, a Japanese traditional herbal medicine, on anorexia and plasma-acylated ghrelin levels in lung cancer patients undergoing cisplatin-based chemotherapy, INVESTIGATIONAL NEW DRUGS, 38巻, 2号, pp. 485-492, 202004
  5. Treatment rationale and design of the PROLONG study: safety and efficacy of pembrolizumab as first-line therapy for elderly patients with non-small cell lung cancer, JOURNAL OF THORACIC DISEASE, 12巻, 3号, pp. 1079-1084, 202003
  6. Serum high-mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis, RESPIROLOGY, 25巻, 3号, pp. 275-280, 202003
  7. Sputum Vitamin D Binding Protein (VDBP) GC1S/1S Genotype Predicts Airway Obstruction: A Prospective Study in Smokers with COPD, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 15巻, pp. 1049-1059, 2020
  8. Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis, RESPIRATORY RESEARCH, 21巻, 1号, 20200611
  9. Final Results from a Phase II Trial of Osimertinib for Elderly Patients with Epidermal Growth Factor Receptor t790m-Positive Non-Small Cell Lung Cancer That Progressed during Previous Treatment, JOURNAL OF CLINICAL MEDICINE, 9巻, 6号, 202006
  10. Acute exacerbation of idiopathic interstitial pneumonias related to chemotherapy for lung cancer: nationwide surveillance in Japan, ERJ OPEN RESEARCH, 6巻, 2号, 20200401
  11. Severe metastatic pulmonary calcification, American Journal of Medicine, 132巻, pp. e733-e734
  12. Pneumatosis cystoides intestinalis in pulmonary mycobacterial disease, British Journal of Hospital Medicine, 80巻
  13. Primary pulmonary collision tumor comprising squamous cell carcinoma and mucosa-associated lymphoid tissue lymphoma, Lung Cancer, 129巻, pp. 107-109
  14. Endobronchial mucosa-associated lymphoid tissue (MALT) lymphoma, QJM, 112巻, pp. 807-808
  15. Acquired T790M-positive squamous cell lung carcinoma that responded to osimertinib, Archivos de Bronconeumologia, 55巻, pp. 602-603
  16. Deep sulcus sign in pneumothorax, Archivos de Bronconeumologia, 55巻, pp. 491
  17. Pulmonary cryptococcosis mimicking lung cancer, LANCET INFECTIOUS DISEASES, 19巻, pp. 1033-1033
  18. Acquired factor V inhibitor after antibiotic treatment in a patient with pneumonia: A case report, Annals of hematology, 98巻, pp. 1989-1990
  19. Secondary pulmonary alveolar proteinosis in acute myeloid leukemia, QJM, 112巻, pp. 293-294
  20. Corticosteroid therapy for organizing pneumonia in a human T-cell lymphotropic virus type-1 carrier, Pulmonology, 25巻, pp. 193-195
  21. Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 185巻, pp. 137-141, 201901
  22. Pericardial Effusion With Tamponade in Lung Cancer Patients During Treatment With Nivolumab: A Report of Two Cases, FRONTIERS IN ONCOLOGY, 9巻, 20190122
  23. Anti-KL-6/MUC1 monoclonal antibody reverses resistance to trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity by capping MUC1, CANCER LETTERS, 442巻, pp. 31-39, 2019
  24. High preoperative C-reactive protein level is a risk factor for acute exacerbation of interstitial lung disease after non-pulmonary surgery, MEDICINE, 98巻, 5号, 201902
  25. Cerebral embolism during edoxaban administration for venous thromboembolism in a patient with lung adenocarcinoma A case report, MEDICINE, 98巻, 12号, 201903
  26. Inhibition of PAI-1 limits chemotherapy resistance in lung cancer through suppressing myofibroblast characteristics of cancer-associated fibroblasts, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 23巻, 4号, pp. 2984-2994, 201904
  27. Performance Status Is a Risk Factor for Depression before the Diagnosis of Lung Cancer Patients, INTERNAL MEDICINE, 58巻, 7号, pp. 915-920, 2019
  28. Photochemical generation of the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) radical from caged nitroxides by near-infrared two-photon irradiation and its cytocidal effect on lung cancer cells, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 15巻, pp. 863-873, 20190410
  29. Suplatast tosilate reduces radiation-induced lung injury in mice through suppression of oxidative stress, FREE RADICAL BIOLOGY AND MEDICINE, 136巻, pp. 52-59, 20190520
  30. Osimertinib in Elderly Patients with Epidermal Growth Factor Receptor T790M-Positive Non-Small-Cell Lung Cancer Who Progressed During Prior Treatment: A Phase II Trial, ONCOLOGIST, 24巻, 5号, pp. 593-+, 201905
  31. Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia, RESPIRATORY MEDICINE, 152巻, pp. 44-50, 201906
  32. A Prospective Cohort Study to Define the Clinical Features and Outcome of Lung Cancers Harboring HER2 Aberration in Japan (HER2-CS STUDY), CHEST, 156巻, 2号, pp. 357-366, 201908
  33. Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-small cell lung cancer, RESPIRATORY INVESTIGATION, 57巻, 5号, pp. 451-459, 201909
  34. Associations of nutrient intakes with obesity and diabetes mellitus in the longitudinal medical surveys of Japanese Americans, JOURNAL OF DIABETES INVESTIGATION, 10巻, 5号, pp. 1229-1236, 201909
  35. C-C Motif Chemokine Ligand 15 May Be a Useful Biomarker for Predicting the Prognosis of Patients with Chronic Hypersensitivity Pneumonitis, RESPIRATION, 98巻, 3号, pp. 212-220, 201909
  36. Platinum-doublet chemotherapy followed by pembrolizumab therapy for lung cancer with lymphangitis carcinomatosa mimicking interstitial pneumonitis A case report, MEDICINE, 98巻, 33号, 201908
  37. Chemotherapy-associated Acute Exacerbation of Interstitial Lung Disease Shortens Survival Especially in Small Cell Lung Cancer, ANTICANCER RESEARCH, 39巻, 10号, pp. 5725-5731, 201910
  38. Role of B7H3/IL-33 Signaling in Pulmonary Fibrosis-induced Profibrogenic Alterations in Bone Marrow, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 200巻, 8号, pp. 1032-1044, 20191015
  39. Alteration of gut microbiota by a Westernized lifestyle and its correlation with insulin resistance in non-diabetic Japanese men, JOURNAL OF DIABETES INVESTIGATION, 10巻, 6号, pp. 1463-1470, 201911
  40. Non-small Cell Lung Cancer Treated by an Anti-programmed Cell Death-1 Antibody without a Flare-up of Preexisting Granulomatosis with Polyangiitis, INTERNAL MEDICINE, 58巻, 21号, pp. 3129-3132, 2019
  41. Serum Antibody Against NY-ESO-1 and XAGE1 Antigens Potentially Predicts Clinical Responses to Anti-Programmed Cell Death-1 Therapy in NSCLC, JOURNAL OF THORACIC ONCOLOGY, 14巻, 12号, pp. 2071-2083, 201912
  42. Baseline High-Resolution CT Findings Predict Acute Exacerbation of Idiopathic Pulmonary Fibrosis: German and Japanese Cohort Study, JOURNAL OF CLINICAL MEDICINE, 8巻, 12号, 201912
  43. Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma, HYPERTENSION, 71巻, 1号, pp. 125-133, 201801
  44. The extent of ground-glass attenuation is a risk factor of chemotherapy-related exacerbation of interstitial lung disease in patients with non-small cell lung cancer, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 81巻, 1号, pp. 131-139, 201801
  45. Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 461巻, C号, pp. 100-104, FEB 5 2018
  46. A Rare Combination of Dermatomyositis, Interstitial Pneumonia, and Lung Cancer in a Patient Treated with Immunosuppressive Therapy and Chemotherapy, INTERNAL MEDICINE, 57巻, 6号, pp. 849-853, 2018
  47. Putative lung adenocarcinoma with epidermal growth factor receptor mutation presenting as carcinoma of unknown primary site A case report, MEDICINE, 97巻, 7号, 201802
  48. Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 103巻, 3号, pp. 965-971, 201803
  49. Nivolumab-induced severe pancytopenia in a patient with lung adenocarcinoma, LUNG CANCER, 119巻, pp. 21-24, 201805
  50. Acetylcholine receptor antibody-positive myasthenia gravis associated with small-cell lung cancer: A case report, MEDICINE, 97巻, 17号, 201804
  51. Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma, EUROPEAN RESPIRATORY JOURNAL, 51巻, 5号, 20180501
  52. Japanese guideline for the treatment of idiopathic pulmonary fibrosis, RESPIRATORY INVESTIGATION, 56巻, 4号, pp. 268-291, 201807
  53. Bevacizumab with Single-agent Chemotherapy in Previously Treated Non-squamous Non-small-cell Lung Cancer: Phase II Study, IN VIVO, 32巻, 5号, pp. 1155-1160, 2018
  54. Use of proton pump inhibitors is associated with increased mortality due to nosocomial pneumonia in bedridden patients receiving tube feeding, GERIATRICS & GERONTOLOGY INTERNATIONAL, 18巻, 8号, pp. 1215-1218, 201808
  55. Intratracheal Administration of siRNA Dry Powder Targeting Vascular Endothelial Growth Factor Inhibits Lung Tumor Growth in Mice, MOLECULAR THERAPY-NUCLEIC ACIDS, 12巻, pp. 698-706, 20180907
  56. Influenza infection presenting with pulmonary congestion: influenza myocarditis, RESPIROLOGY CASE REPORTS, 6巻, 7号, OCT 2018
  57. Plasminogen activator inhibitor-1 serves an important role in radiation-induced pulmonary fibrosis, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 16巻, 4号, pp. 3070-3076, OCT 2018
  58. Alternate-day administration of S-1 for elderly patients with advanced non-small-cell lung carcinoma: A prospective feasibility study, MOLECULAR AND CLINICAL ONCOLOGY, 9巻, 5号, pp. 539-544, 201811
  59. Effects of Hochuekkito combined with pulmonary rehabilitation in patients with chronic obstructive pulmonary disease, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 16巻, 6号, pp. 5236-5242, 201812
  60. Multicenter phase II study on cisplatin, pemetrexed, and bevacizumab followed by maintenance with pemetrexed and bevacizumab for patients with advanced or recurrent nonsquamous non-small cell lung cancer: MAP study, BMC CANCER, 18巻, 20181210
  61. Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels, STEROIDS, 140巻, pp. 179-184, 201812
  62. Small-Cell Lung Cancer Comorbid with Pulmonary Mycobacterium avium Infection: A Case Report, CHEMOTHERAPY, 63巻, 5号, pp. 257-261, 2018
  63. Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody A retrospective cohort study, MEDICINE, 97巻, 49号, 201812
  64. Nivolumab therapy for lung cancer with tracheo-parenchymal fistula A case report, MEDICINE, 97巻, 50号, 201812
  65. Vertebral Osteomyelitis that Developed During Chemotherapy for Lung Cancer, UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, 28巻, 3号, pp. 199-200, 2018
  66. Small Cell Lung Cancer with Bizarre Radiographic Findings, INTERNAL MEDICINE, 57巻, 23号, pp. 3493-3494, 2018
  67. Clinically remitted childhood asthma is associated with airflow obstruction in middle-aged adults, RESPIROLOGY, 22巻, 1号, pp. 86-92, 201701
  68. Carboplatin plus Weekly Paclitaxel Combined with Bevacizumab as First-line Treatment for Non-small Cell Lung Cancer, ANTICANCER RESEARCH, 37巻, 2号, pp. 923-928, 201702
  69. Mustard gas exposure and mortality among retired workers at a poisonous gas factory in Japan: a 57-year follow-up cohort study, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 74巻, 5号, pp. 321-327, 201705
  70. Immunological evaluation of peptide vaccination for cancer patients with the HLA-A11(+) or-A33(+) allele, CANCER SCIENCE, 108巻, 4号, pp. 598-603, 201704
  71. Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals, FREE RADICAL BIOLOGY AND MEDICINE, 106巻, pp. 1-9, 201705
  72. AGER gene polymorphisms and soluble receptor for advanced glycation end product in patients with idiopathic pulmonary fibrosis, RESPIROLOGY, 22巻, 5号, pp. 965-971, 201707
  73. Westernization of lifestyle affects quantitative and qualitative changes in adiponectin, CARDIOVASCULAR DIABETOLOGY, 16巻, 20170706
  74. Association between aerobic capacity and the improvement in glycemic control after the exercise training in type 2 diabetes, DIABETOLOGY & METABOLIC SYNDROME, 9巻, 20170818
  75. Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets, BMC MEDICAL GENETICS, 18巻, 20170818
  76. CLINICAL AND MOLECULAR FEATURES OF RAPIDLY PROGRESSIVE CHRONIC HYPERSENSITIVITY PNEUMONITIS, SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 34巻, 1号, pp. 48-57, 2017
  77. Chronic Intestinal Pseudo-obstruction and Orthostatic Hypotension Associated with Small Cell Lung Cancer that Improved with Tumor Reduction after Chemoradiotherapy, INTERNAL MEDICINE, 56巻, 19号, pp. 2627-2631, 2017
  78. Risk factors for stomatitis in patients with lymphangioleiomyomatosis during treatment with sirolimus: A multicenter investigator-initiated prospective study, PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 26巻, 10号, pp. 1182-1189, 201710
  79. Feasibility Study of Personalized Peptide Vaccination for Advanced Small Cell Lung Cancer, CLINICAL LUNG CANCER, 18巻, 6号, pp. E385-E394, 201711
  80. AGER rs2070600 polymorphism elevates neutrophil-lymphocyte ratio and mortality in metastatic lung adenocarcinoma, ONCOTARGET, 8巻, 55号, pp. 94382-94392, 20171107
  81. Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated with Lymphangioleiomyomatosis, INTERNAL MEDICINE, 56巻, 24号, pp. 3327-3331, 2017
  82. Leucine-rich alpha-2 glycoprotein promotes lung fibrosis by modulating TGF-beta signaling in fibroblasts, PHYSIOLOGICAL REPORTS, 5巻, 24号, 201712
  83. FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 123巻, pp. 105-109, 201702
  84. Comparative efficacies of daptomycin, vancomycin, and linezolid in experimental enterococcal peritonitis, JOURNAL OF INFECTION AND CHEMOTHERAPY, 23巻, 7号, pp. 498-501, 2017
  85. MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study, BMC CANCER, 17巻, pp. 263, 20170412
  86. 放射線治療によって改善を認めた肺腺癌の下垂体転移を原因とする中枢性尿崩症の1 例, 癌と化学療法, 44巻, 6号, pp. 513-516
  87. ACO:喘息とCOPDのオーバーラップ.検査所見・バイオマーカー, Pharma Medica, 35巻, pp. 31-35
  88. 重症難治性気管支喘息に対する気管支サーモプラスティ, 広島医学, 70巻, 6号, pp. 291-292
  89. Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-beta-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts, PLOS ONE, 11巻, 2号, 20160209
  90. Postoperative gluteal skin damage associated with latent development of gluteal muscle damage, JOURNAL OF DERMATOLOGY, 43巻, 5号, pp. 547-552, 201605
  91. Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis, DISEASE MARKERS, 20160317
  92. Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers, INHALATION TOXICOLOGY, 28巻, 8号, pp. 343-348, 201607
  93. Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma, CANCER RESEARCH, 76巻, 11号, pp. 3285-3294, 20160601
  94. Sputum Leucine-Rich Alpha-2 Glycoprotein as a Marker of Airway Inflammation in Asthma, PLOS ONE, 11巻, 9号, 20160909
  95. Characterization of sputum biomarkers for asthma-COPD overlap syndrome, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 11巻, pp. 2457-2465, 20160930
  96. Efficacy and Safety of Long-Term Sirolimus Therapy for Asian Patients with Lymphangioleiomyomatosis, ANNALS OF THE AMERICAN THORACIC SOCIETY, 13巻, 11号, pp. 1912-1922, 201611
  97. ACOSのバイオマーカー, 臨床免疫・アレルギー科, 66巻, pp. 476-481
  98. Airway inflammation in Japanese COPD patients compared with smoking and nonsmoking controls, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 10巻, pp. 185-192, 2015
  99. Effect of increasing respiratory rate on airway resistance and reactance in COPD patients, RESPIROLOGY, 20巻, 1号, pp. 87-94, 201501
  100. Effects of a 6-month nurse-led self-management program on comprehensive pulmonary rehabilitation for patients with COPD receiving home oxygen therapy., Rehabilitation Nursing, 40巻, 1号, pp. 40-51, 2015
  101. Evaluation of prognostic significance of granulocyte-related factors in cancer patients undergoing personalized peptide vaccination, HUMAN VACCINES & IMMUNOTHERAPEUTICS, 11巻, 12号, pp. 2784-2789, 20151202
  102. Histological Quantification of Gene Silencing by Intratracheal Administration of Dry Powdered Small-Interfering RNA/Chitosan Complexes in the Murine Lung, PHARMACEUTICAL RESEARCH, 32巻, 12号, pp. 3877-3885, 201512
  103. Immunological evaluation of peptide vaccination for cancer patients with the HLA-A26 allele, CANCER SCIENCE, 106巻, 10号, pp. 1257-1263, 201510
  104. MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model, CANCER SCIENCE, 106巻, 7号, pp. 921-928, 201507
  105. MUC5B promoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis, RESPIROLOGY, 20巻, 3号, pp. 439-444, APR 2015
  106. 薬剤性肺障害を疑うポイントと検査の進め方 (特集 薬剤性肺障害のとらえ方), 月刊薬事 = The pharmaceuticals monthly, 57巻, 2号, pp. 197-200, 201502
  107. 薬剤性浮腫のためクリゾチニブが継続不能となり,アレクチニブへの変更投与により副作用なく部分奏効が得られたEML4-ALK融合遺伝子陽性肺腺癌の1例, 肺癌, 55巻, 4号, pp. 212-217, 2015
  108. 間質性肺炎の血清バイオマーカー KL-6., 臨床化学, 44巻, 1号, pp. 24-29, Jan 2015
  109. 薬剤性肺障害を疑うポイントと検査の進め方, 薬事, 2巻, 57号, pp. 197-200, Feb 2015
  110. 高用量の抗真菌薬併用療法が奏効した治療抵抗性侵襲性肺アスペルギルス症の1例, 呼吸, 34巻, 4号, pp. 416-420, April 2015
  111. ペメトレキセドを含む化学療法中の発熱に関する後方視的検討, 広島医学, 68巻, 2号, pp. 97-100, Feb 2015
  112. 2次治療としてカルボプラチンとナブパクリタキセルによる化学療法が奏効した胸腺癌の1例, 日本胸部臨床, 74巻, 8号, pp. 900-908, August 2015
  113. 結核性胸膜炎治療中に遅発性の胸膜結核腫を発症した1例, 呼吸, 34巻, 10号, pp. 1014-1015, Oct 2015
  114. Baseline KL-6 predicts increased risk for acute exacerbation of idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 108巻, 7号, pp. 1031-1039, 201407
  115. Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms, BMC MEDICAL GENETICS, 15巻, 20140108
  116. これでわかる!最新のバイオマーカー(第5回)間質性肺炎のバイオマーカー, Respiratory medical research, 2巻, 4号, pp. 256-259, 201410
  117. 薬剤性肺障害の診断に必要な検査(1)血液検査,気管支鏡検査,薬剤リンパ球刺激試験(DLST)の意義を中心に (第1土曜特集 内科領域の薬剤性障害 : 肝・肺を中心に) -- (薬剤性肺障害), 医学のあゆみ, 248巻, 1号, pp. 81-85, 20140104
  118. すべての臨床医が知っておくべき薬剤性肺障害.[どうやって見つける?]診断のコツとピットフォール., Mebio, pp. 10-14, December 2014
  119. Characteristics of inspiratory and expiratory reactance in interstitial lung disease, RESPIRATORY MEDICINE, 107巻, 6号, pp. 875-882, 201306
  120. Cross-sectional and prospective study of the association between lung function and prediabetes, BMJ Open, 3巻, 2号, 20130320
  121. Reply to letter to the Editor: rs4072037 Polymorphisms and their role in gastrointestinal carcinogenesis, RESPIRATORY MEDICINE, 107巻, 1号, pp. 159-159, 2013
  122. SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis, Molecular Cancer Therapeutics, 12巻, 11号, pp. 2378-2388, 20131101
  123. 薬剤性肺障害の検査 (特集 薬剤性肺障害の手引き), アレルギー・免疫, 20巻, 3号, pp. 364-370, 201303
  124. 薬剤性肺障害の診断 (特集 薬剤性肺障害の臨床), 呼吸と循環, 61巻, 4号, pp. 313-318, 201304
  125. 薬剤性肺障害の免疫反応 (特集 免疫学的機序からみた呼吸器疾患), 日本胸部臨床, 72巻, 12号, pp. 1346-1354, 201312
  126. Cigarette smoking decreases dynamic inspiratory capacity during maximal exercise in patients with type 2 diabetes., Hiroshima J Med Sci, 20120601
  127. Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels, RESPIRATORY MEDICINE, 106巻, 12号, pp. 1756-1764, 201212
  128. Interferon(alpha, beta and omega) receptor2 is a prognostic biomarker for lung cancer., Pathobiology, 20120101
  129. Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected nonsmall cell lung cancer, INTERNATIONAL JOURNAL OF CANCER, 130巻, 2号, pp. 377-387, 20120115
  130. PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury, JOURNAL OF PATHOLOGY, 228巻, 2号, pp. 170-180, 201210
  131. Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases, Respiratory Investigation, 50巻, 1号, pp. 3-13, 20120301
  132. 血清ACE上昇からサルコイドーシスとの鑑別を要した Hodgkin lymphoma の1例, 日本内科学会雑誌, 101巻, 5号, pp. 1401-1403, 20120510
  133. 臨床研究 COPDの咳嗽に対する麦門冬湯の鎮咳効果 (特集 咳と痰 : 漢方ファースト・ステップ), 漢方医学, 36巻, 1号, pp. 26-29, 2012
  134. A pilot study of the multiherb Kampo medicine bakumondoto for cough in patients with chronic obstructive pulmonary disease., Phytomedicine, 18巻, 8-9号, pp. 625-629, 20110601
  135. Aberrant promoter methylation of WIF-1 and SFRP1, 2, 4 genes in mesothelioma, Oncology Reports, 24巻, 2号, pp. 423-431, 20100101
  136. Association of airway inflammation with asthma control level evaluated by the asthma control test, J Asthma, 48巻, 9号, pp. 907-913, 20110901
  137. Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease, Respir Res, 12巻, pp. 97-107, 20110701
  138. Chronic Hepatitis C Virus Infection is Associated with More Severe Asthma., Allergol Int, 60巻, 3号, pp. 299-304, 20110301
  139. Clinical significance of CD151 gene expression in non-small cell lung cancer, Clinical Cancer Research, 7巻, 12号, pp. 4109-4114, 20011201
  140. Effect of Mustard Gas Exposure on Incidence of Lung Cancer: A Longitudinal Study, AMERICAN JOURNAL OF EPIDEMIOLOGY, 173巻, 6号, pp. 659-666, 2011
  141. Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy., Cancer Chemother Pharmacol, 67巻, 6号, pp. 1465-9, 20110101
  142. Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., Am J Physiol Lung Cell Mol Physiol, 301巻, 6号, pp. L908-916, 20110901
  143. KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome, RESPIRATORY RESEARCH, 12巻, 2011
  144. Levels of surfactant proteins A and D and KL-6 are elevated in the induced sputum of chronic obstructive pulmonary disease patients: A sequential, Respiration, 82巻, 1号, pp. 10-18, 20110401
  145. Nicergoline improves Dysphagia by upregulating substance p in the elderly, Medicine (Baltimore), 90巻, 4号, pp. 279-283, 20110701
  146. Phase I study docetaxel plus S-1 combination chemotherapy for recurrent non-small cell lung cancer., Oncology Letters, 2巻, pp. 167-170, 20110101
  147. Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy, Hiroshima Journal of Medical Sciences, 60巻, 1号, pp. 7-9, 20110301
  148. びまん性肺疾患におけるバイオマーカー (特集 びまん性肺疾患のマイル・ストーン), 綜合臨床, 60巻, 12号, pp. 2416-2418, 201112
  149. 小細胞肺癌の治療後の瘢痕より発生した腺扁平上皮癌の1切除例, 肺癌, 51巻, 3号, pp. 182-187, 2011
  150. 肺性肥大性骨関節症を合併した肺多形癌の1例, 日本呼吸器学会雑誌, 49巻, 10号, pp. 765-768, 20111001
  151. Mucins carrying selectin ligands as predictive biomarkers of disseminated intravascular coagulation complication in ARDS., Chest, 139巻, 2号, pp. 296-304, 20100701
  152. Productive cough is an independent risk factor for the development of COPD in former smokers, RESPIROLOGY, 15巻, 2号, pp. 313-318, 201002
  153. Suppression of plasminogen activatior inhibitor-1 by RNA interference attenuates pulmonary fibrosis., Thorax, 65巻, 4号, pp. 334-340, 20100401
  154. The influence of lung function on exercise capacity in patients with type 2 diabetes, Hiroshima Journal of Medical Sciences, 59巻, 1号, pp. 7-13, 20100301
  155. 抗凝固・線溶療法について (特集 間質性肺炎治療法の新展開), 呼吸と循環, 58巻, 4号, pp. 383-387, 201004
  156. ‘09~’10年新型インフルエンザの流行を振り返って, 広島県医師協だより, 476号, pp. 5-10, 20100601
  157. Airflow limitation in smokers is associated with subclinical atherosclerosis, American Journal of Respiratory and Critical Care Medicine, 179巻, 1号, pp. 35-40, 20090101
  158. Genetic ablation of the Bach1 gene reduces hyperoxic lung injury in mice: Role of IL-6, FREE RADICAL BIOLOGY AND MEDICINE, 46巻, 8号, pp. 1119-1126, 2009
  159. IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure, Clinical and Experimental Allergy, 39巻, 2号, pp. 290-298, 20090201
  160. Lymphocyte transformation test is not helpful for the diagnosis of methotrexate-induced pneumonitis in patients with rheumatoid arthritis., Clin Chim Acta, 407巻, 1-2号, pp. 25-29, 20090901
  161. Metastatic breast cancer presenting as air-space consolidation on chest computed tomography., Intern Med, 48巻, 9号, pp. 727-731, 20090301
  162. Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice, J Pharmacol Exp Ther, 328巻, 1号, pp. 55-61, 20090101
  163. 呼吸器疾患のバイオマーカー (特集 呼吸器疾患診断の進歩--形態と機能の系統的評価), 呼吸と循環, 57巻, 4号, pp. 365-373, 200904
  164. Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease, Pulm Pharmacol Ther, 21巻, 6号, pp. 874-878, 20081201
  165. Circulating KL-6/MUC1 as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome, Journal of Internal Medicine, 263巻, 4号, pp. 432-439, 20080401
  166. Suppressor of cytokine signaling1 inhibits pulmonary inflammation and fibrosis, J Allergy Clin Immun, 121巻, 5号, pp. 1269-1276, 20080201
  167. Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype, European Respiratory Journal, 31巻, 6号, pp. 1379-1380, 20080601
  168. Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors, INTERNATIONAL JOURNAL OF CANCER, 122巻, 11号, pp. 2612-2620, 20080601
  169. バイオマーカーの有用性と問題点, 呼吸器科, 14巻, 2号, pp. 104-108, 20080801
  170. 間質性肺炎の血清マーカー, 呼吸器科, 13巻, 4号, pp. 297-302, 20080401
  171. A case of pulmonary asbestosis presenting with temporal arteritis involving multiple medium-sized vessels., Mod Rheumatol, 18巻, 1号, pp. 100-104, 20071201
  172. A causal relationship between overproduction of collagen and the diminished SOCS1 expression in fibroblasts from idiopathic pulmonary fibrosis., Biochemical and Biophysisal Research Communications, 353巻, 4号, pp. 1004-10, 20070223
  173. Adenoviral transduction of MRP-1/CD9 and KAI1/CD82 inhibits lymph node metastasis in orthotopic lung cancer model., Cancer Research, 67巻, 4号, pp. 1744-1749, 20070215
  174. Circulating KL-6/MUC1 mucin carrying sialyl Lewis(a) oligosaccharide is an independent prognostic factor in patients with lung adenocarcinoma., International journal of cancer, 120巻, 12号, pp. 2643-9, 20070615
  175. Differetial expression of the glycosylated forms of MUC1 during lung development, Eur J Histochem, 51巻, 2号, pp. 95-102, 20070401
  176. Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis, Biochemical and Biophysical Research Communications, 353巻, 4号, pp. 1004-1010, 20070223
  177. 症例からみる肺疾患のCT画像:膠原病に伴う間質性肺炎, medicina, 44巻, 2号, pp. 302-304, 20070210
  178. 新しい検査の意義と使い方 : 4. KL-6とSP-D, 日本内科学会雑誌, 96巻, 10号, pp. 2144-2150, 20071010
  179. 新しい検査の意義と使い方 KL-6とSP-D, 日本内科学会雑誌, 96巻, 10号, pp. 2144-2150, 20070901
  180. Anti-tumor effect of the anti-KL-6/MUC1 monoclonal antibody through exposure of surface molecules by MUC1 capping, Cancer Science, 97巻, 5号, pp. 420-429, 20060501
  181. Clinical significance of aminopeptidase N in non-small cell lung cancer., Clinical Cancer Res., 12巻, 13号, pp. 3971-3978, 20060601
  182. Effect of CPAP on brachial-ankle pulse wave velocity in patients with OSAHS: An open-labelled study, Respiratory Medicine, 100巻, 12号, pp. 2160-2169, 20061201
  183. 家族性間質性肺炎とSP-Cのかかわりをみる, 分子呼吸器病, 10巻, 2号, pp. 58-60, 20060301
  184. 間質性肺炎・肺線維症:遺伝子多型をめぐる最近の進歩をみる, 分子呼吸器病, 10巻, 1号, pp. 21-26, 20060101
  185. 間質性肺炎の理解 : 肺線維化の機序について, 治療学, 40巻, pp. 1165-1168, 2006
  186. 間質性肺炎の理解:肺線維化の機序について, 治療学, 40巻, 11号, pp. 11-14, 20061101
  187. 肺線維化マーカーの測定意義, 検査と技術, 34巻, 11号, pp. 1170-1171, 20061101
  188. 慢性乾性咳嗽の鑑別診断と治療, Pharma Medica, 24巻, 1号, pp. 110-112, 20060101
  189. KL-6, a human MUC1 mucin, promotes proliferation and survival of lung fibroblasts, Biochemical and Biophysical Research Communications, 338巻, 4号, pp. 1845-1852, 20051230
  190. 気管支拡張剤無効の慢性咳嗽に対するプランルカストの効果, 医学と薬学, 54巻, pp. 209-212, 2005
  191. The Plasminogen Activation System Reduces Fibrosis in the Lung by a Hepatocyte Growth Factor-Dependent Mechanism, American Journal of Pathology, 164巻, 3号, pp. 1091-1098, 20040301
  192. 凝固線溶系薬剤 (特集 ARDS/ALIの薬物療法), 呼吸と循環, 52巻, 8号, pp. 793-798, 200408
  193. A plasminogen activator inhibitor-1 promoter polymorphism and idiopathic interstitial pneumonia, Molecular Medicine, 9巻, 1-2号, pp. 52-56, 20030101
  194. Clinical significance of transmembrane 4 superfamily in colon cancer, British Journal of Cancer, 89巻, 1号, pp. 158-167, 20030707
  195. Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1, American Journal of Pathology, 163巻, 2号, pp. 445-452, 20030801
  196. Inducible lung-specific urokinase expression reduces fibrosis and mortality after lung injury in mice, American Journal of Physiology - Lung Cellular and Molecular Physiology, 283巻, 5 27-5号, pp. L1023-L1032, 20021101
  197. 2次性肺胞蛋白症及び全身アスペルギルス感染症を認めたALLの1剖検例, 日本胸部疾患学会雑誌, 31巻, 3号, pp. 374-378, 1993
  198. 長期完全寛解持続中に歯肉に再発を生じた赤白血病の1例, 臨床血液, 32巻, 1号, pp. 29-33, 1991
  199. Clinical significance of aminopeptidase N/CD13 expression in human pancreatic carcinoma, Clinical Cancer Research, 9巻, 4号, pp. 1503-1508, 20030401
  200. Clinical significance of aminopeptidase N in non-small cell lung cancer, Clinical Cancer Research, 12巻, 13号, pp. 3971-3978, 20060701
  201. Adenoviral transduction of MRP-1/CD9 and KAI1/CD82 inhibits lymph node metastasis in orthotopic lung cancer model, Cancer Research, 67巻, 4号, pp. 1744-1749, 20070215
  202. 薬剤性浮腫のためクリゾチニブが継続不能となり、アレクチニブへの変更投与により副作用なく部分奏効が得られたEML4-ALK融合遺伝子陽性肺腺癌の1例, 肺癌, 55巻, 4号, pp. 212-217, August 2015

著書等出版物

  1. 治療法の再整理とアップデートのために, 専門家による私の治療 IgG4関連呼吸器疾患, 日本医事新報, 2019年, その他, 単著
  2. 医薬品副作用学(上), 臓器・系統別副作用概論 呼吸器障害, 日本臨床, 2019年, 単行本(学術書), 共著
  3. 透析患者の検査値の読み方 第4版, 間質性肺炎のマーカー(KL-6, SP-A, SP-D), 2019年, 単行本(学術書), 共著
  4. 2008年06月, 気管支肺胞洗浄「BAL」の手引き, 京誠堂出版, 2008年, 06, 単行本(学術書), 共編著, 9784771903371, 111
  5. 2007年11月, 呼吸器専門医テキスト, 南江堂, 2007年, 11, 単行本(学術書), 共編著, 9784524238415, 740
  6. 2010年02月, 呼吸器疾患最新治療2010-2012, 南江, 2010年, 02, 単行本(学術書), 共編著, 516
  7. 2010年08月, 特発性肺線維症(IPF), 医薬ジャーナル社, 2010年, 08, 単行本(学術書), 共編著, 280
  8. 2011年05月, 呼吸器研修ノート (研修ノートシリーズ), 診断と治療社, 2011年, 05, 単行本(学術書), 編著, 4787817981, 840
  9. 2009年12月, まんがで読み解く呼吸器症例100 (まんがで読み解くシリーズ), メディカルレビュー社, 2009年, 12, 単行本(学術書), 編著, 4779203732, 283
  10. 2010年02月, 呼吸器疾患最新治療2010-2012, 南江堂, 2010年, 02, 単行本(学術書), 共編著, 524
  11. 2014年04月, 呼吸器外科の術前術後ケア, メディカ出版, 2014年, 4, 単行本(学術書), 共著
  12. 2014年06月, インフォームドコンセントのための図説シリーズ, 医薬ジャーナル社, 2014年, 6, 単行本(学術書), 共著
  13. 特発性間質性肺炎 診断と治療の手引き.改訂第3版., 2016年, 単行本(学術書), 共著
  14. 内科学 11版.(朝倉書店), 2017年, 教科書, 共著
  15. 私の治療 2017-18年度版.(日本医事新報社), 2017年, 単行本(学術書), 共著
  16. 呼吸器疾患診断治療アプローチ 2呼吸器感染症(中山書店), 2017年, 単行本(学術書), 共著
  17. 2018年01月15日, 2018年, 単行本(学術書), 共著
  18. 呼吸器疾患―最新の治療―2019‐2020, 薬剤性肺障害, 南江堂, 2019年, 単行本(学術書), 共著
  19. 肺がん化学療法副作用マネジメント.(メディカルレビュー社), 創傷治癒遅延, メディカルレビュー社, 2019年, 単行本(学術書), 共著