NOBORU HATTORI

Last Updated :2025/08/07

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Professor
E-mail
nhattorihiroshima-u.ac.jp
Self-introduction
I am a physcian majoring in respiratory medicine. I am also making a research on pulmonary fiborisis and thoracic malignancies.

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Kyoto University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Respiratory organ internal medicine

Research Keywords

  • Pulmonary fibrosis
  • Thoracic malignancy

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2025, Undergraduate Education, Intensive, Practice for medical research
  3. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2025, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2025, Graduate Education (Master's Program) , 1Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance A
  6. 2025, Graduate Education (Doctoral Program) , 1Term, Principles of Oncology
  7. 2025, Graduate Education (Doctoral Program) , 1Term, Practice of Oncology
  8. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Molecular and internal Medicine
  9. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Molecular and internal Medicine
  10. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Molecular and internal Medicine
  11. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Molecular and internal Medicine
  12. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Multidisciplinary Tumor Board
  13. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Multidisciplinary Tumor Board

Research Activities

Academic Papers

  1. A case of miliary pulmonary cryptococcosis showing different changes in CT images of the left and right lungs., Respiratory Endoscopy, 2(1), 36-40, 202402
  2. Physical Activity and Sedentary Time Correlate with Body Composition in Patients with Asthma; a Multicenter Observational Study, JOURNAL OF ASTHMA AND ALLERGY, 18, 835-846, 2025
    Link to Paper Search Results by DOI
  3. Prognostic prediction for newly diagnosed patients with idiopathic interstitial pneumonia: JIPS Registry (NEJ030), RESPIRATORY INVESTIGATION, 63(3), 365-372, 202505
    Link to Paper Search Results by DOI
  4. Refractory phenotype of Aspergillus-sensitized asthma with bronchiectasis and allergic bronchopulmonary aspergillosis, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY: GLOBAL, 4(1), 202502
    Link to Paper Search Results by DOI
  5. Impact of 2018 Japan floods on allergic rhinitis prescriptions, WORLD ALLERGY ORGANIZATION JOURNAL, 18(5), 202505
    Link to Paper Search Results by DOI
  6. Clinical characteristics of drug-induced interstitial pneumonia in Japan, RESPIRATORY INVESTIGATION, 63(4), 524-531, 202507
    Link to Paper Search Results by DOI
  7. Association Between Introduction of the 23-valent Pneumococcal Polysaccharide Vaccine (PPSV23) and Pneumonia Incidence and Mortality Among General Older Population in Japan: A Community-Based Study, JOURNAL OF EPIDEMIOLOGY, 35(5), 237-244, 202505
    Link to Paper Search Results by DOI
  8. Predictive Value of Circulatory Total VEGF-A and VEGF-A Isoforms for the Efficacy of Anti-PD-1/PD-L1 Antibodies in Patients with Non-Small-Cell Lung Cancer, CANCERS, 17(4), 202502
    Link to Paper Search Results by DOI
  9. Prognostic Awareness and Knowledge of Acute Exacerbation in Patients Dying with Interstitial Lung Disease A Nationwide Survey, ANNALS OF THE AMERICAN THORACIC SOCIETY, 22(3), 202503
    Link to Paper Search Results by DOI
  10. Serum Soluble Toll-Like Receptor 4 is a Predictive Biomarker for Acute Exacerbation and Prognosis of Idiopathic Pulmonary Fibrosis: A Retrospective Study, LUNG, 203(1), 202512
    Link to Paper Search Results by DOI
  11. HMGB1 assists the predictive value of tumor PD-L1 expression for the efficacy of anti-PD-1/PD-L1 antibody in NSCLC, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 95(1), 202512
    Link to Paper Search Results by DOI
  12. Non-tuberculous mycobacterial shoulder arthritis with acute exacerbation soon after initiation of immune checkpoint inhibitor: A case report, JOURNAL OF INFECTION AND CHEMOTHERAPY, 31(3), 202503
    Link to Paper Search Results by DOI
  13. Blood culture bottles for culturing cerebrospinal fluid in cases of bacterial meningitis caused by Enterococcus faecalis: A case report, JOURNAL OF INFECTION AND CHEMOTHERAPY, 31(1), 202501
    Link to Paper Search Results by DOI
  14. Efficacy of immune checkpoint inhibitors according to programmed cell death-ligand 1 expression in patients with non-small cell lung cancer and brain metastasis: A real-world prospective observational study, THORACIC CANCER, 15(34), 2408-2417, 202412
    Link to Paper Search Results by DOI
  15. A Case of Granulocyte-Colony-Stimulating Factor-Producing Non-Small Cell Lung Cancer under Steroid Treatment and with Poor Performance Status That Responded to Pembrolizumab, CASE REPORTS IN ONCOLOGY, 17(1), 1115-1123, 2024
    Link to Paper Search Results by DOI
  16. Usefulness of Quantification and Serial Monitoring of Fine Crackles for Early Detection of Treatment-related Lung Injury: A Report of Two Cases, INTERNAL MEDICINE, 63(12), 1783-1787, 2024
    Link to Paper Search Results by DOI
  17. Automated immunoassay of serum NY-ESO-1 and XAGE1 antibodies for predicting clinical benefit with immune checkpoint inhibitor (ICI) in advanced non-small cell lung cancer, CANCER TREATMENT AND RESEARCH COMMUNICATIONS, 40, 2024
    Link to Paper Search Results by DOI
  18. Serum soluble isoform of receptor for advanced glycation end product is a predictive biomarker for acute exacerbation of idiopathic pulmonary fibrosis: a German and Japanese cohort study, RESPIRATORY RESEARCH, 25(1), 20241111
    Link to Paper Search Results by DOI
  19. Primary pulmonary extranodal NK/T-cell lymphoma diagnosed by thoracoscopic lung biopsy: A case report, RESPIRATORY MEDICINE CASE REPORTS, 52, 2024
    Link to Paper Search Results by DOI
  20. Sex-related differences in efficacy of bone marrow-derived high aldehyde dehydrogenase activity cells against pulmonary fibrosis, STEM CELL RESEARCH & THERAPY, 15(1), 20240915
    Link to Paper Search Results by DOI
  21. Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome-Wide Association and Mendelian Randomization Study, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 13(15), 20240806
    Link to Paper Search Results by DOI
  22. Treatment rationale and protocol design: an investigator-initiated phase II study of combination treatment of nivolumab and TM5614, a PAI-1 inhibitor for previously treated patients with non-small cell lung cancer, JOURNAL OF THORACIC DISEASE, 16(5), 3381-3388, 202405
    Link to Paper Search Results by DOI
  23. Immunoprecipitation with an Anti-Epitope Tag Affinity Gelto Study Protein-Protein Interactions, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 202401
    Link to Paper Search Results by DOI
  24. A case of pleural mesothelioma with immunohistochemical staining positive for Krebs von den Lungen-6, RESPIRATORY MEDICINE CASE REPORTS, 50, 2024
    Link to Paper Search Results by DOI
  25. Plasma extracellular vesicle proteins as promising noninvasive biomarkers for diagnosis of idiopathic pulmonary fibrosis., Journal of Extracellular Biology, 2(7), e98, 202307
  26. Lipocalin-2 as a prognostic marker in patients with acute exacerbation of idiopathic pulmonary fibrosis, RESPIRATORY RESEARCH, 25(1), 20240504
    Link to Paper Search Results by DOI
  27. Intestinal overgrowth of Candida albicans exacerbates bleomycin-induced pulmonary fibrosis in mice with dysbiosis, JOURNAL OF PATHOLOGY, 261(2), 227-237, 202310
    Link to Paper Search Results by DOI
  28. High S100A9 level predicts poor survival, and the S100A9 inhibitor paquinimod is a candidate for treating idiopathic pulmonary fibrosis, BMJ OPEN RESPIRATORY RESEARCH, 11(1), 202402
    Link to Paper Search Results by DOI
  29. A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib, SCIENTIFIC REPORTS, 13(1), 20231227
    Link to Paper Search Results by DOI
  30. The EGFR C797S Mutation Confers Resistance to a Novel EGFR Inhibitor CLN-081 to EGFR Exon 20 Insertion Mutations, JTO CLINICAL AND RESEARCH REPORTS, 4(3), 202303
    Link to Paper Search Results by DOI
  31. Peak expiratory flow, but not tongue pressure, can predict pneumonia development in older adults, EUROPEAN GERIATRIC MEDICINE, 14(1), 211-217, 202302
    Link to Paper Search Results by DOI
  32. Hypoxia-inducible factor 1ﾎｱ modulates interstitial pneumonia-mediated lung cancer progression, JOURNAL OF TRANSLATIONAL MEDICINE, 21(1), 20231127
    Link to Paper Search Results by DOI
  33. Significance of micro-EGFR T790M mutations on EGFR-tyrosine kinase inhibitor efficacy in non-small cell lung cancer, SCIENTIFIC REPORTS, 13(1), 20231113
    Link to Paper Search Results by DOI
  34. Identification of kynurenine and quinolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases, RESPIRATORY RESEARCH, 25(1), 20240114
    Link to Paper Search Results by DOI
  35. Nestin and Notch3 collaboratively regulate angiogenesis, collagen production, and endothelial-mesenchymal transition in lung endothelial cells, CELL COMMUNICATION AND SIGNALING, 21(1), 20230921
    Link to Paper Search Results by DOI
  36. Concurrent Mutations in STK11 and KEAP1 Cause Treatment Resistance in KRAS Wild-type Non-small-cell Lung Cancer, INTERNAL MEDICINE, 62(20), 3001-3004, 2023
    Link to Paper Search Results by DOI
  37. Exhaled Nitric Oxide and Olfactory Dysfunction in Patients with Asthma: Association with Chronic Rhinosinusitis, MEDICINA-LITHUANIA, 59(10), 202310
    Link to Paper Search Results by DOI
  38. Prospective Real-World Analysis of Asthma Patients With Preserved and Reduced Physical Activity, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 11(9), 2792-+, 202309
    Link to Paper Search Results by DOI
  39. Effect of Dupilumab in a Patient With Severe Asthma Complicated With Recurrent Anaphylaxis: A Case Report, JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, 33(3), 230-232, 2023
    Link to Paper Search Results by DOI
  40. Clinical characteristics of extrapulmonary nontuberculous mycobacteria infections in comparison with pulmonary infections: A single-center, retrospective study in Japan, JOURNAL OF INFECTION AND CHEMOTHERAPY, 29(9), 875-881, 202309
    Link to Paper Search Results by DOI
  41. Selective activation of PPAR alpha maintains thermogenic capacity of beige adipocytes, ISCIENCE, 26(7), 20230721
    Link to Paper Search Results by DOI
  42. Pulmonary alveolar proteinosis after lung transplantation: Two case reports and literature review, RESPIROLOGY CASE REPORTS, 11(6), 202306
    Link to Paper Search Results by DOI
  43. Lung and Cerebral Nocardiosis Caused by Nocardia elegans in a Lung Transplant Recipient: A Case Report and Literature Review, INTERNAL MEDICINE, 62(3), 431-437, 20230201
    Link to Paper Search Results by DOI
  44. Genetic Risk of Primary Aldosteronism and Its Contribution to Hypertension: A Cross-Ancestry Meta-Analysis of Genome-Wide Association Studies, CIRCULATION, 147(14), 1097-1109, 20230404
    Link to Paper Search Results by DOI
  45. Serum and bronchoalveolar lavage fluid levels of soluble B7H3 in patients with interstitial lung diseases, RESPIRATORY MEDICINE, 212, 202306
    Link to Paper Search Results by DOI
  46. Predictive value of serum high-mobility group box 1 levels for checkpoint inhibitor pneumonitis, RESPIROLOGY, 28(4), 380-388, 202304
    Link to Paper Search Results by DOI
  47. Preserved ratio impaired spirometry with or without restrictive spirometric abnormality, SCIENTIFIC REPORTS, 13(1), 20230220
    Link to Paper Search Results by DOI
  48. Design and rationale of the Japanese Idiopathic Interstitial Pneumonias (JIPS) Registry, RESPIRATORY INVESTIGATION, 61(1), 95-102, 202301
    Link to Paper Search Results by DOI
  49. Association between Plasminogen Activator Inhibitor-1 and Osimertinib Tolerance in EGFR-Mutated Lung Cancer via Epithelial-Mesenchymal Transition, CANCERS, 15(4), 202302
    Link to Paper Search Results by DOI
  50. Pre-Existing Interstitial Lung Abnormalities Are Independent Risk Factors for Interstitial Lung Disease during Durvalumab Treatment after Chemoradiotherapy in Patients with Locally Advanced Non-Small-Cell Lung Cancer, CANCERS, 14(24), 202212
    Link to Paper Search Results by DOI
  51. Nationwide survey of refractory asthma with bronchiectasis by inflammatory subtypes, RESPIRATORY RESEARCH, 23(1), 20221220
    Link to Paper Search Results by DOI
  52. Association of the RAGE/RAGE-ligand axis with interstitial lung disease and its acute exacerbation, RESPIRATORY INVESTIGATION, 60(4), 531-542, 202207
    Link to Paper Search Results by DOI
  53. Association Between Patient Preference for Inhaler Medications and Asthma Outcomes, JOURNAL OF ASTHMA AND ALLERGY, 15, 1539-1547, 2022
    Link to Paper Search Results by DOI
  54. Dupilumab as an adjunct treatment for a patient with steroid-dependent immunoglobulin G4-related disease complicated by asthma: a case report, JOURNAL OF ASTHMA, 59(12), 2395-2401, 20221110
    Link to Paper Search Results by DOI
  55. Identification and characterization of lysophosphatidylcholine 14:0 as a biomarker for drug-induced lung disease, SCIENTIFIC REPORTS, 12(1), 20221117
    Link to Paper Search Results by DOI
  56. Prevalence of immune-related adverse events and anti-tumor efficacy following immune checkpoint inhibitor therapy in Japanese patients with various solid tumors, BMC CANCER, 22(1), 20221129
    Link to Paper Search Results by DOI
  57. Prediction model for patient prognosis in idiopathic pulmonary fibrosis using hybrid radiomics analysis., Research in Diagnostic and Interventional Imaging, 4, 100017-100017, 202212
  58. Predictive role of circulatory levels of high-mobility group box 1 for radiation pneumonitis in patients with non-small cell lung cancer treated with definitive thoracic radiotherapy, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 27(11), 1698-1705, 202211
    Link to Paper Search Results by DOI
  59. Validity and reliability of the Japanese version of the Dyspnea-12 questionnaire in patients with lung cancer., Journal of Pain and Symptom Management, 64(2), e83-e89, 202208
  60. Pneumonia and Meningoencephalitis Due to Varicella-zoster Virus Reinfection and Epstein-Barr Virus Reactivation in a Patient with Rheumatoid Arthritis, INTERNAL MEDICINE, 61(19), 2961-2965, 2022
    Link to Paper Search Results by DOI
  61. Association of DNA methylation with steroidogenic enzymes in Cushing's adenoma, ENDOCRINE-RELATED CANCER, 29(8), 495-502, 202208
    Link to Paper Search Results by DOI
  62. Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage, NATURE COMMUNICATIONS, 13(1), 20221004
    Link to Paper Search Results by DOI
  63. Hochuekkito Combined with Pulmonary Rehabilitation in Apathetic Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Pilot Trial, JOURNAL OF CLINICAL MEDICINE, 11(19), 202210
    Link to Paper Search Results by DOI
  64. Secondary pulmonary alveolar proteinosis in a patient with systemic lupus erythematosus., Pulmonology, 27(1), 81-83, 202101
  65. Cryptococcal meningitis in a patient with rheumatoid arthritis treated with abatacept., Journal of Clinical Rheumatology, 27(8S), S701-S702, 20211201
  66. Atezolizumab-induced sclerosing cholangitis in a patient with lung cancer: a case report., Cancer Treatment and Research Communications, 26, 100270-100270, 202106
  67. Characteristic computed tomography features in mesenchymal-epithelial transition exon14 skipping-positive non-small cell lung cancer, BMC PULMONARY MEDICINE, 22(1), 20220630
    Link to Paper Search Results by DOI
  68. Role of Soluble Receptor for Advanced Glycation End Products in Postoperative Fibrotic Lung Injury, ANNALS OF THORACIC SURGERY, 113(5), 1617-1623, 202205
    Link to Paper Search Results by DOI
  69. Vocal cord dysfunction detected by a three-dimensional image of dynamic change in respiratory resistance in a patient with difficult-to-treat asthma: a case report, JOURNAL OF ASTHMA, 59(6), 1157-1161, 20220603
    Link to Paper Search Results by DOI
  70. Switching Treatment from Mepolizumab to Benralizumab for Elderly Patients with Severe Eosinophilic Asthma: A Retrospective Observational Study, INTERNAL MEDICINE, 61(11), 1663-1671, 2022
    Link to Paper Search Results by DOI
  71. Primary Pulmonary Mucosa-associated Lymphoid Tissue Lymphoma with the High Expression of IgG4, INTERNAL MEDICINE, 61(7), 1043-1048, 2022
    Link to Paper Search Results by DOI
  72. Hypomethylation associated vitamin D receptor expression in ATP1A1 mutant aldosterone-producing adenoma, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 548, 20220515
    Link to Paper Search Results by DOI
  73. Tolerability and efficacy of IMpower133 regimen modified for dialysis patients with extensive-stage small cell lung cancer: Two case reports, THORACIC CANCER, 12(21), 2956-2960, 202111
    Link to Paper Search Results by DOI
  74. Pulmonary Alveolar Proteinosis with Severe Respiratory Failure Improved by Segmental Lung Lavage with Fiberoptic Bronchoscopy under General Anesthesia, INTERNAL MEDICINE, 61(3), 389-393, 2022
    Link to Paper Search Results by DOI
  75. Conversion from Positive to Negative EGFR Mutation due to Clonal Selection during Long-Term Treatment with Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors: A Case Report, CASE REPORTS IN ONCOLOGY, 14(3), 1447-1453, 2021
    Link to Paper Search Results by DOI
  76. Pneumatosis Intestinalis following Radiation Esophagitis during Chemoradiotherapy for Lung Cancer: A Case Report, CASE REPORTS IN ONCOLOGY, 14(3), 1454-1459, 2021
    Link to Paper Search Results by DOI
  77. Accelerated decline in lung function in adults with a history of remitted childhood asthma, EUROPEAN RESPIRATORY JOURNAL, 59(1), 20220101
    Link to Paper Search Results by DOI
  78. First-line osimertinib treatment in a patient with lung adenocarcinoma with coexisting epidermal growth factor receptor G719S and de novo T790M mutations, THORACIC CANCER, 13(5), 771-774, 202203
    Link to Paper Search Results by DOI
  79. Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-beta-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts, PLOS ONE, 11(2), 20160209
    Link to Paper Search Results by DOI
  80. Airway inflammation in Japanese COPD patients compared with smoking and nonsmoking controls, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 10, 185-192, 2015
    Link to Paper Search Results by DOI
  81. Effect of increasing respiratory rate on airway resistance and reactance in COPD patients, RESPIROLOGY, 20(1), 87-94, 201501
    Link to Paper Search Results by DOI
  82. Effects of a 6-month nurse-led self-management program on comprehensive pulmonary rehabilitation for patients with COPD receiving home oxygen therapy., Rehabilitation Nursing, 40(1), 40-51, 2015
    Link to Paper Search Results by DOI
  83. Evaluation of prognostic significance of granulocyte-related factors in cancer patients undergoing personalized peptide vaccination, HUMAN VACCINES & IMMUNOTHERAPEUTICS, 11(12), 2784-2789, 20151202
    Link to Paper Search Results by DOI
  84. Histological Quantification of Gene Silencing by Intratracheal Administration of Dry Powdered Small-Interfering RNA/Chitosan Complexes in the Murine Lung, PHARMACEUTICAL RESEARCH, 32(12), 3877-3885, 201512
    Link to Paper Search Results by DOI
  85. Immunological evaluation of peptide vaccination for cancer patients with the HLA-A26 allele, CANCER SCIENCE, 106(10), 1257-1263, 201510
    Link to Paper Search Results by DOI
  86. MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model, CANCER SCIENCE, 106(7), 921-928, 201507
    Link to Paper Search Results by DOI
  87. MUC5B promoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis, RESPIROLOGY, 20(3), 439-444, 201504
    Link to Paper Search Results by DOI
  88. Baseline KL-6 predicts increased risk for acute exacerbation of idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 108(7), 1031-1039, 201407
    Link to Paper Search Results by DOI
  89. Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms, BMC MEDICAL GENETICS, 15, 20140108
    Link to Paper Search Results by DOI
  90. Characteristics of inspiratory and expiratory reactance in interstitial lung disease, RESPIRATORY MEDICINE, 107(6), 875-882, 201306
    Link to Paper Search Results by DOI
  91. Cross-sectional and prospective study of the association between lung function and prediabetes, BMJ Open, 3(2), 20130320
  92. Reply to letter to the Editor: rs4072037 Polymorphisms and their role in gastrointestinal carcinogenesis, RESPIRATORY MEDICINE, 107(1), 159-159, 2013
  93. SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis, Molecular Cancer Therapeutics, 12(11), 2378-2388, 20131101
  94. Cigarette smoking decreases dynamic inspiratory capacity during maximal exercise in patients with type 2 diabetes., Hiroshima J Med Sci, 20120601
  95. Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels, RESPIRATORY MEDICINE, 106(12), 1756-1764, 201212
    Link to Paper Search Results by DOI
  96. Interferon(alpha, beta and omega) receptor2 is a prognostic biomarker for lung cancer., Pathobiology, 20120101
  97. Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected nonsmall cell lung cancer, INTERNATIONAL JOURNAL OF CANCER, 130(2), 377-387, 20120115
    Link to Paper Search Results by DOI
  98. PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury, JOURNAL OF PATHOLOGY, 228(2), 170-180, 201210
    Link to Paper Search Results by DOI
  99. Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases, Respiratory Investigation, 50(1), 3-13, 20120301
  100. A pilot study of the multiherb Kampo medicine bakumondoto for cough in patients with chronic obstructive pulmonary disease., Phytomedicine, 18(8-9), 625-629, 20110601
  101. Aberrant promoter methylation of WIF-1 and SFRP1, 2, 4 genes in mesothelioma, Oncology Reports, 24(2), 423-431, 20100101
  102. Association of airway inflammation with asthma control level evaluated by the asthma control test, J Asthma, 48(9), 907-913, 20110901
  103. Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease, Respir Res, 12, 97-107, 20110701
  104. Chronic Hepatitis C Virus Infection is Associated with More Severe Asthma., Allergol Int, 60(3), 299-304, 20110301
  105. Clinical significance of CD151 gene expression in non-small cell lung cancer, Clinical Cancer Research, 7(12), 4109-4114, 20011201
  106. Effect of Mustard Gas Exposure on Incidence of Lung Cancer: A Longitudinal Study, AMERICAN JOURNAL OF EPIDEMIOLOGY, 173(6), 659-666, 2011
  107. Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy., Cancer Chemother Pharmacol, 67(6), 1465-9, 20110101
  108. Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., Am J Physiol Lung Cell Mol Physiol, 301(6), L908-916, 20110901
  109. KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome, RESPIRATORY RESEARCH, 12, 2011
  110. Levels of surfactant proteins A and D and KL-6 are elevated in the induced sputum of chronic obstructive pulmonary disease patients: A sequential, Respiration, 82(1), 10-18, 20110401
  111. Nicergoline improves Dysphagia by upregulating substance p in the elderly, Medicine (Baltimore), 90(4), 279-283, 20110701
  112. Phase I study docetaxel plus S-1 combination chemotherapy for recurrent non-small cell lung cancer., Oncology Letters, 2, 167-170, 20110101
  113. Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy, Hiroshima Journal of Medical Sciences, 60(1), 7-9, 20110301
  114. Mucins carrying selectin ligands as predictive biomarkers of disseminated intravascular coagulation complication in ARDS., Chest, 139(2), 296-304, 20100701
  115. Productive cough is an independent risk factor for the development of COPD in former smokers, RESPIROLOGY, 15(2), 313-318, 201002
    Link to Paper Search Results by DOI
  116. Suppression of plasminogen activatior inhibitor-1 by RNA interference attenuates pulmonary fibrosis., Thorax, 65(4), 334-340, 20100401
  117. The influence of lung function on exercise capacity in patients with type 2 diabetes, Hiroshima Journal of Medical Sciences, 59(1), 7-13, 20100301
  118. Airflow limitation in smokers is associated with subclinical atherosclerosis, American Journal of Respiratory and Critical Care Medicine, 179(1), 35-40, 20090101
  119. Genetic ablation of the Bach1 gene reduces hyperoxic lung injury in mice: Role of IL-6, FREE RADICAL BIOLOGY AND MEDICINE, 46(8), 1119-1126, 2009
  120. IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure, Clinical and Experimental Allergy, 39(2), 290-298, 20090201
  121. Lymphocyte transformation test is not helpful for the diagnosis of methotrexate-induced pneumonitis in patients with rheumatoid arthritis., Clin Chim Acta, 407(1-2), 25-29, 20090901
  122. Metastatic breast cancer presenting as air-space consolidation on chest computed tomography., Intern Med, 48(9), 727-731, 20090301
  123. Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice, J Pharmacol Exp Ther, 328(1), 55-61, 20090101
  124. Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease, Pulm Pharmacol Ther, 21(6), 874-878, 20081201
  125. Circulating KL-6/MUC1 as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome, Journal of Internal Medicine, 263(4), 432-439, 20080401
  126. Suppressor of cytokine signaling1 inhibits pulmonary inflammation and fibrosis, J Allergy Clin Immun, 121(5), 1269-1276, 20080201
  127. Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype, European Respiratory Journal, 31(6), 1379-1380, 20080601
  128. Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors, INTERNATIONAL JOURNAL OF CANCER, 122(11), 2612-2620, 20080601
    Link to Paper Search Results by DOI
  129. A case of pulmonary asbestosis presenting with temporal arteritis involving multiple medium-sized vessels., Mod Rheumatol, 18(1), 100-104, 20071201
  130. A causal relationship between overproduction of collagen and the diminished SOCS1 expression in fibroblasts from idiopathic pulmonary fibrosis., Biochemical and Biophysisal Research Communications, 353(4), 1004-10, 20070223
  131. Adenoviral transduction of MRP-1/CD9 and KAI1/CD82 inhibits lymph node metastasis in orthotopic lung cancer model., Cancer Research, 67(4), 1744-1749, 20070215
  132. Circulating KL-6/MUC1 mucin carrying sialyl Lewis(a) oligosaccharide is an independent prognostic factor in patients with lung adenocarcinoma., International journal of cancer, 120(12), 2643-9, 20070615
  133. Differetial expression of the glycosylated forms of MUC1 during lung development, Eur J Histochem, 51(2), 95-102, 20070401
  134. Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis, Biochemical and Biophysical Research Communications, 353(4), 1004-1010, 20070223
  135. Anti-tumor effect of the anti-KL-6/MUC1 monoclonal antibody through exposure of surface molecules by MUC1 capping, Cancer Science, 97(5), 420-429, 20060501
  136. Clinical significance of aminopeptidase N in non-small cell lung cancer., Clinical Cancer Res., 12(13), 3971-3978, 20060601
  137. Effect of CPAP on brachial-ankle pulse wave velocity in patients with OSAHS: An open-labelled study, Respiratory Medicine, 100(12), 2160-2169, 20061201
  138. KL-6, a human MUC1 mucin, promotes proliferation and survival of lung fibroblasts, Biochemical and Biophysical Research Communications, 338(4), 1845-1852, 20051230
  139. The Plasminogen Activation System Reduces Fibrosis in the Lung by a Hepatocyte Growth Factor-Dependent Mechanism, American Journal of Pathology, 164(3), 1091-1098, 20040301
  140. A plasminogen activator inhibitor-1 promoter polymorphism and idiopathic interstitial pneumonia, Molecular Medicine, 9(1-2), 52-56, 20030101
  141. Clinical significance of transmembrane 4 superfamily in colon cancer, British Journal of Cancer, 89(1), 158-167, 20030707
  142. Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1, American Journal of Pathology, 163(2), 445-452, 20030801
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Publications such as books

  1. 2023/01/11, Advances in Clinical Chemistry, Immune checkpoint therapy and response biomarkers in non-small-cell lung cancer: Serum NY-ESO-1 and XAGE1 antibody as predictive and monitoring markers., 2023, 01, Scholarly Book, Joint work, Koji Kurose, Kanako Sakaeda, Minoru Fukuda, Yumiko Sakai, Hiroyuki Yamaguchi, Shinnosuke Takemoto, Katsuhiko Shimizu, Takeshi Masuda, Katsumi Nakatomi, Shigeo Kawase, Ryo Tanaka, Takayuki Suetsugu, Keiko Mizuno, Takehiro Hasegawa, Yusuke Atarashi, Yasuhiro Irino, Toshiyuki Sato, Hiromasa Inoue, Noboru Hattori, Eiichiro Kanda, Masao Nakata, Hiroshi Mukae, Toru Oga, and Mikio Oka
  2. 2020, Acute Respiratory Distress Syndrome, Serum markers of ARDS: How can we know the severity and prognosis from the serum markers?, Springer Nature, 2020, Scholarly Book, Joint work
  3. 2018/01/15, Drug-Induced Ling Injury., Blood tests for the diagnosis and/or management of DLI: what are the clinical significances of KL-6, SP-A, SP-D and DLST in DLI., Springer, 2018, Scholarly Book, Joint work