Last Updated :2022/09/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
I am a physcian majoring in respiratory medicine. I am also making a research on pulmonary fiborisis and thoracic malignancies.

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Kyoto University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Respiratory organ internal medicine

Research Keywords

  • Pulmonary fibrosis
  • Thoracic malignancy

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, Year, Clinical diagnosis and treatment I
  2. 2022, Undergraduate Education, Intensive, Practice for medical research
  3. 2022, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2022, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2022, Graduate Education (Master's Program) , 3Term, Advanced Lecture on Preventive Medicine for Evidence-based Health Guidance B
  6. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Molecular and internal Medicine
  7. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Molecular and internal Medicine
  8. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Molecular and internal Medicine
  9. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Molecular and internal Medicine

Research Activities

Academic Papers

  1. Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-beta-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts, PLOS ONE, 11(2), 20160209
  2. Airway inflammation in Japanese COPD patients compared with smoking and nonsmoking controls, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 10, 185-192, 2015
  3. Effect of increasing respiratory rate on airway resistance and reactance in COPD patients, RESPIROLOGY, 20(1), 87-94, 201501
  4. Effects of a 6-month nurse-led self-management program on comprehensive pulmonary rehabilitation for patients with COPD receiving home oxygen therapy., Rehabilitation Nursing, 40(1), 40-51, 2015
  5. Evaluation of prognostic significance of granulocyte-related factors in cancer patients undergoing personalized peptide vaccination, HUMAN VACCINES & IMMUNOTHERAPEUTICS, 11(12), 2784-2789, 20151202
  6. Histological Quantification of Gene Silencing by Intratracheal Administration of Dry Powdered Small-Interfering RNA/Chitosan Complexes in the Murine Lung, PHARMACEUTICAL RESEARCH, 32(12), 3877-3885, 201512
  7. Immunological evaluation of peptide vaccination for cancer patients with the HLA-A26 allele, CANCER SCIENCE, 106(10), 1257-1263, 201510
  8. MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model, CANCER SCIENCE, 106(7), 921-928, 201507
  9. MUC5B promoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis, RESPIROLOGY, 20(3), 439-444, 201504
  10. Baseline KL-6 predicts increased risk for acute exacerbation of idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 108(7), 1031-1039, 201407
  11. Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms, BMC MEDICAL GENETICS, 15, 20140108
  12. Characteristics of inspiratory and expiratory reactance in interstitial lung disease, RESPIRATORY MEDICINE, 107(6), 875-882, 201306
  13. Cross-sectional and prospective study of the association between lung function and prediabetes, BMJ Open, 3(2), 20130320
  14. Reply to letter to the Editor: rs4072037 Polymorphisms and their role in gastrointestinal carcinogenesis, RESPIRATORY MEDICINE, 107(1), 159-159, 2013
  15. SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis, Molecular Cancer Therapeutics, 12(11), 2378-2388, 20131101
  16. Cigarette smoking decreases dynamic inspiratory capacity during maximal exercise in patients with type 2 diabetes., Hiroshima J Med Sci, 20120601
  17. Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels, RESPIRATORY MEDICINE, 106(12), 1756-1764, 201212
  18. Interferon(alpha, beta and omega) receptor2 is a prognostic biomarker for lung cancer., Pathobiology, 20120101
  19. Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected nonsmall cell lung cancer, INTERNATIONAL JOURNAL OF CANCER, 130(2), 377-387, 20120115
  20. PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury, JOURNAL OF PATHOLOGY, 228(2), 170-180, 201210
  21. Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases, Respiratory Investigation, 50(1), 3-13, 20120301
  22. A pilot study of the multiherb Kampo medicine bakumondoto for cough in patients with chronic obstructive pulmonary disease., Phytomedicine, 18(8-9), 625-629, 20110601
  23. Aberrant promoter methylation of WIF-1 and SFRP1, 2, 4 genes in mesothelioma, Oncology Reports, 24(2), 423-431, 20100101
  24. Association of airway inflammation with asthma control level evaluated by the asthma control test, J Asthma, 48(9), 907-913, 20110901
  25. Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease, Respir Res, 12, 97-107, 20110701
  26. Chronic Hepatitis C Virus Infection is Associated with More Severe Asthma., Allergol Int, 60(3), 299-304, 20110301
  27. Clinical significance of CD151 gene expression in non-small cell lung cancer, Clinical Cancer Research, 7(12), 4109-4114, 20011201
  28. Effect of Mustard Gas Exposure on Incidence of Lung Cancer: A Longitudinal Study, AMERICAN JOURNAL OF EPIDEMIOLOGY, 173(6), 659-666, 2011
  29. Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy., Cancer Chemother Pharmacol, 67(6), 1465-9, 20110101
  30. Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice., Am J Physiol Lung Cell Mol Physiol, 301(6), L908-916, 20110901
  31. KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome, RESPIRATORY RESEARCH, 12, 2011
  32. Levels of surfactant proteins A and D and KL-6 are elevated in the induced sputum of chronic obstructive pulmonary disease patients: A sequential, Respiration, 82(1), 10-18, 20110401
  33. Nicergoline improves Dysphagia by upregulating substance p in the elderly, Medicine (Baltimore), 90(4), 279-283, 20110701
  34. Phase I study docetaxel plus S-1 combination chemotherapy for recurrent non-small cell lung cancer., Oncology Letters, 2, 167-170, 20110101
  35. Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy, Hiroshima Journal of Medical Sciences, 60(1), 7-9, 20110301
  36. Mucins carrying selectin ligands as predictive biomarkers of disseminated intravascular coagulation complication in ARDS., Chest, 139(2), 296-304, 20100701
  37. Productive cough is an independent risk factor for the development of COPD in former smokers, RESPIROLOGY, 15(2), 313-318, 201002
  38. Suppression of plasminogen activatior inhibitor-1 by RNA interference attenuates pulmonary fibrosis., Thorax, 65(4), 334-340, 20100401
  39. The influence of lung function on exercise capacity in patients with type 2 diabetes, Hiroshima Journal of Medical Sciences, 59(1), 7-13, 20100301
  40. Airflow limitation in smokers is associated with subclinical atherosclerosis, American Journal of Respiratory and Critical Care Medicine, 179(1), 35-40, 20090101
  41. Genetic ablation of the Bach1 gene reduces hyperoxic lung injury in mice: Role of IL-6, FREE RADICAL BIOLOGY AND MEDICINE, 46(8), 1119-1126, 2009
  42. IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure, Clinical and Experimental Allergy, 39(2), 290-298, 20090201
  43. Lymphocyte transformation test is not helpful for the diagnosis of methotrexate-induced pneumonitis in patients with rheumatoid arthritis., Clin Chim Acta, 407(1-2), 25-29, 20090901
  44. Metastatic breast cancer presenting as air-space consolidation on chest computed tomography., Intern Med, 48(9), 727-731, 20090301
  45. Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice, J Pharmacol Exp Ther, 328(1), 55-61, 20090101
  46. Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease, Pulm Pharmacol Ther, 21(6), 874-878, 20081201
  47. Circulating KL-6/MUC1 as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome, Journal of Internal Medicine, 263(4), 432-439, 20080401
  48. Suppressor of cytokine signaling1 inhibits pulmonary inflammation and fibrosis, J Allergy Clin Immun, 121(5), 1269-1276, 20080201
  49. Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype, European Respiratory Journal, 31(6), 1379-1380, 20080601
  50. Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors, INTERNATIONAL JOURNAL OF CANCER, 122(11), 2612-2620, 20080601
  51. A case of pulmonary asbestosis presenting with temporal arteritis involving multiple medium-sized vessels., Mod Rheumatol, 18(1), 100-104, 20071201
  52. A causal relationship between overproduction of collagen and the diminished SOCS1 expression in fibroblasts from idiopathic pulmonary fibrosis., Biochemical and Biophysisal Research Communications, 353(4), 1004-10, 20070223
  53. Adenoviral transduction of MRP-1/CD9 and KAI1/CD82 inhibits lymph node metastasis in orthotopic lung cancer model., Cancer Research, 67(4), 1744-1749, 20070215
  54. Circulating KL-6/MUC1 mucin carrying sialyl Lewis(a) oligosaccharide is an independent prognostic factor in patients with lung adenocarcinoma., International journal of cancer, 120(12), 2643-9, 20070615
  55. Differetial expression of the glycosylated forms of MUC1 during lung development, Eur J Histochem, 51(2), 95-102, 20070401
  56. Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis, Biochemical and Biophysical Research Communications, 353(4), 1004-1010, 20070223
  57. Anti-tumor effect of the anti-KL-6/MUC1 monoclonal antibody through exposure of surface molecules by MUC1 capping, Cancer Science, 97(5), 420-429, 20060501
  58. Clinical significance of aminopeptidase N in non-small cell lung cancer., Clinical Cancer Res., 12(13), 3971-3978, 20060601
  59. Effect of CPAP on brachial-ankle pulse wave velocity in patients with OSAHS: An open-labelled study, Respiratory Medicine, 100(12), 2160-2169, 20061201
  60. KL-6, a human MUC1 mucin, promotes proliferation and survival of lung fibroblasts, Biochemical and Biophysical Research Communications, 338(4), 1845-1852, 20051230
  61. The Plasminogen Activation System Reduces Fibrosis in the Lung by a Hepatocyte Growth Factor-Dependent Mechanism, American Journal of Pathology, 164(3), 1091-1098, 20040301
  62. A plasminogen activator inhibitor-1 promoter polymorphism and idiopathic interstitial pneumonia, Molecular Medicine, 9(1-2), 52-56, 20030101
  63. Clinical significance of transmembrane 4 superfamily in colon cancer, British Journal of Cancer, 89(1), 158-167, 20030707
  64. Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1, American Journal of Pathology, 163(2), 445-452, 20030801
  65. Inducible lung-specific urokinase expression reduces fibrosis and mortality after lung injury in mice, American Journal of Physiology - Lung Cellular and Molecular Physiology, 283(5 27-5), L1023-L1032, 20021101
  66. Clinical significance of aminopeptidase N/CD13 expression in human pancreatic carcinoma, Clinical Cancer Research, 9(4), 1503-1508, 20030401
  67. Clinical significance of aminopeptidase N in non-small cell lung cancer, Clinical Cancer Research, 12(13), 3971-3978, 20060701
  68. Adenoviral transduction of MRP-1/CD9 and KAI1/CD82 inhibits lymph node metastasis in orthotopic lung cancer model, Cancer Research, 67(4), 1744-1749, 20070215
  69. Postoperative gluteal skin damage associated with latent development of gluteal muscle damage, JOURNAL OF DERMATOLOGY, 43(5), 547-552, 201605
  70. Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis, DISEASE MARKERS, 20160317
  71. Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers, INHALATION TOXICOLOGY, 28(8), 343-348, 201607
  72. Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma, CANCER RESEARCH, 76(11), 3285-3294, 20160601
  73. Sputum Leucine-Rich Alpha-2 Glycoprotein as a Marker of Airway Inflammation in Asthma, PLOS ONE, 11(9), 20160909
  74. Characterization of sputum biomarkers for asthma-COPD overlap syndrome, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 11, 2457-2465, 20160930
  75. Efficacy and Safety of Long-Term Sirolimus Therapy for Asian Patients with Lymphangioleiomyomatosis, ANNALS OF THE AMERICAN THORACIC SOCIETY, 13(11), 1912-1922, 201611
  76. Clinically remitted childhood asthma is associated with airflow obstruction in middle-aged adults, RESPIROLOGY, 22(1), 86-92, 201701
  77. Carboplatin plus Weekly Paclitaxel Combined with Bevacizumab as First-line Treatment for Non-small Cell Lung Cancer, ANTICANCER RESEARCH, 37(2), 923-928, 201702
  78. Mustard gas exposure and mortality among retired workers at a poisonous gas factory in Japan: a 57-year follow-up cohort study, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 74(5), 321-327, 201705
  79. Immunological evaluation of peptide vaccination for cancer patients with the HLA-A11(+) or-A33(+) allele, CANCER SCIENCE, 108(4), 598-603, 201704
  80. Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals, FREE RADICAL BIOLOGY AND MEDICINE, 106, 1-9, 201705
  81. AGER gene polymorphisms and soluble receptor for advanced glycation end product in patients with idiopathic pulmonary fibrosis, RESPIROLOGY, 22(5), 965-971, 201707
  82. Westernization of lifestyle affects quantitative and qualitative changes in adiponectin, CARDIOVASCULAR DIABETOLOGY, 16, 20170706
  83. Association between aerobic capacity and the improvement in glycemic control after the exercise training in type 2 diabetes, DIABETOLOGY & METABOLIC SYNDROME, 9, 20170818
  84. Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets, BMC MEDICAL GENETICS, 18, 20170818
  86. Chronic Intestinal Pseudo-obstruction and Orthostatic Hypotension Associated with Small Cell Lung Cancer that Improved with Tumor Reduction after Chemoradiotherapy, INTERNAL MEDICINE, 56(19), 2627-2631, 2017
  87. Risk factors for stomatitis in patients with lymphangioleiomyomatosis during treatment with sirolimus: A multicenter investigator-initiated prospective study, PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 26(10), 1182-1189, 201710
  88. Feasibility Study of Personalized Peptide Vaccination for Advanced Small Cell Lung Cancer, CLINICAL LUNG CANCER, 18(6), E385-E394, 201711
  89. AGER rs2070600 polymorphism elevates neutrophil-lymphocyte ratio and mortality in metastatic lung adenocarcinoma, ONCOTARGET, 8(55), 94382-94392, 20171107
  90. Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma, HYPERTENSION, 71(1), 125-133, 201801
  91. Additional Octreotide Therapy to Sirolimus Achieved a Decrease in Sirolimus-refractory Chylous Effusion Complicated with Lymphangioleiomyomatosis, INTERNAL MEDICINE, 56(24), 3327-3331, 2017
  92. Leucine-rich alpha-2 glycoprotein promotes lung fibrosis by modulating TGF-beta signaling in fibroblasts, PHYSIOLOGICAL REPORTS, 5(24), 201712
  93. The extent of ground-glass attenuation is a risk factor of chemotherapy-related exacerbation of interstitial lung disease in patients with non-small cell lung cancer, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 81(1), 131-139, 201801
  94. FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 123, 105-109, 201702
  95. Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 461(C), 100-104, 2018
  96. A Rare Combination of Dermatomyositis, Interstitial Pneumonia, and Lung Cancer in a Patient Treated with Immunosuppressive Therapy and Chemotherapy, INTERNAL MEDICINE, 57(6), 849-853, 2018
  97. Putative lung adenocarcinoma with epidermal growth factor receptor mutation presenting as carcinoma of unknown primary site A case report, MEDICINE, 97(7), 201802
  98. Purkinje Cell Protein 4 Expression Is Associated With DNA Methylation Status in Aldosterone-Producing Adenoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 103(3), 965-971, 201803
  99. Nivolumab-induced severe pancytopenia in a patient with lung adenocarcinoma, LUNG CANCER, 119, 21-24, 201805
  100. Acetylcholine receptor antibody-positive myasthenia gravis associated with small-cell lung cancer: A case report, MEDICINE, 97(17), 201804
  101. Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma, EUROPEAN RESPIRATORY JOURNAL, 51(5), 20180501
  102. Japanese guideline for the treatment of idiopathic pulmonary fibrosis, RESPIRATORY INVESTIGATION, 56(4), 268-291, 201807
  103. Comparative efficacies of daptomycin, vancomycin, and linezolid in experimental enterococcal peritonitis, JOURNAL OF INFECTION AND CHEMOTHERAPY, 23(7), 498-501, 201707
  104. MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study, BMC CANCER, 17, 263, 20170412
  105. Bevacizumab with Single-agent Chemotherapy in Previously Treated Non-squamous Non-small-cell Lung Cancer: Phase II Study, IN VIVO, 32(5), 1155-1160, 2018
  106. Use of proton pump inhibitors is associated with increased mortality due to nosocomial pneumonia in bedridden patients receiving tube feeding, GERIATRICS & GERONTOLOGY INTERNATIONAL, 18(8), 1215-1218, 201808
  107. Intratracheal Administration of siRNA Dry Powder Targeting Vascular Endothelial Growth Factor Inhibits Lung Tumor Growth in Mice, MOLECULAR THERAPY-NUCLEIC ACIDS, 12, 698-706, 20180907
  108. Influenza infection presenting with pulmonary congestion: influenza myocarditis, RESPIROLOGY CASE REPORTS, 6(7), 201810
  109. Plasminogen activator inhibitor-1 serves an important role in radiation-induced pulmonary fibrosis, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 16(4), 3070-3076, 201810
  110. Alternate-day administration of S-1 for elderly patients with advanced non-small-cell lung carcinoma: A prospective feasibility study, MOLECULAR AND CLINICAL ONCOLOGY, 9(5), 539-544, 201811
  111. Effects of Hochuekkito combined with pulmonary rehabilitation in patients with chronic obstructive pulmonary disease, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 16(6), 5236-5242, 201812
  112. Multicenter phase II study on cisplatin, pemetrexed, and bevacizumab followed by maintenance with pemetrexed and bevacizumab for patients with advanced or recurrent nonsquamous non-small cell lung cancer: MAP study, BMC CANCER, 18, 20181210
  113. Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels, STEROIDS, 140, 179-184, 201812
  114. Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 185, 137-141, 201901
  115. Small-Cell Lung Cancer Comorbid with Pulmonary Mycobacterium avium Infection: A Case Report, CHEMOTHERAPY, 63(5), 257-261, 2018
  116. Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody A retrospective cohort study, MEDICINE, 97(49), 201812
  117. Nivolumab therapy for lung cancer with tracheo-parenchymal fistula A case report, MEDICINE, 97(50), 201812
  118. Pericardial Effusion With Tamponade in Lung Cancer Patients During Treatment With Nivolumab: A Report of Two Cases, FRONTIERS IN ONCOLOGY, 9, 20190122
  119. Anti-KL-6/MUC1 monoclonal antibody reverses resistance to trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity by capping MUC1, CANCER LETTERS, 442, 31-39, 2019
  120. High preoperative C-reactive protein level is a risk factor for acute exacerbation of interstitial lung disease after non-pulmonary surgery, MEDICINE, 98(5), 201902
  121. Cerebral embolism during edoxaban administration for venous thromboembolism in a patient with lung adenocarcinoma A case report, MEDICINE, 98(12), 201903
  122. Inhibition of PAI-1 limits chemotherapy resistance in lung cancer through suppressing myofibroblast characteristics of cancer-associated fibroblasts, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 23(4), 2984-2994, 201904
  123. Performance Status Is a Risk Factor for Depression before the Diagnosis of Lung Cancer Patients, INTERNAL MEDICINE, 58(7), 915-920, 2019
  124. Photochemical generation of the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) radical from caged nitroxides by near-infrared two-photon irradiation and its cytocidal effect on lung cancer cells, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 15, 863-873, 20190410
  125. Suplatast tosilate reduces radiation-induced lung injury in mice through suppression of oxidative stress, FREE RADICAL BIOLOGY AND MEDICINE, 136, 52-59, 20190520
  126. Osimertinib in Elderly Patients with Epidermal Growth Factor Receptor T790M-Positive Non-Small-Cell Lung Cancer Who Progressed During Prior Treatment: A Phase II Trial, ONCOLOGIST, 24(5), 593-+, 201905
  127. Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia, RESPIRATORY MEDICINE, 152, 44-50, 201906
  128. A Prospective Cohort Study to Define the Clinical Features and Outcome of Lung Cancers Harboring HER2 Aberration in Japan (HER2-CS STUDY), CHEST, 156(2), 357-366, 201908
  129. Vertebral Osteomyelitis that Developed During Chemotherapy for Lung Cancer, UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, 28(3), 199-200, 2018
  130. Small Cell Lung Cancer with Bizarre Radiographic Findings, INTERNAL MEDICINE, 57(23), 3493-3494, 2018
  131. Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-small cell lung cancer, RESPIRATORY INVESTIGATION, 57(5), 451-459, 201909
  132. Associations of nutrient intakes with obesity and diabetes mellitus in the longitudinal medical surveys of Japanese Americans, JOURNAL OF DIABETES INVESTIGATION, 10(5), 1229-1236, 201909
  133. C-C Motif Chemokine Ligand 15 May Be a Useful Biomarker for Predicting the Prognosis of Patients with Chronic Hypersensitivity Pneumonitis, RESPIRATION, 98(3), 212-220, 201909
  134. Platinum-doublet chemotherapy followed by pembrolizumab therapy for lung cancer with lymphangitis carcinomatosa mimicking interstitial pneumonitis A case report, MEDICINE, 98(33), 201908
  135. Chemotherapy-associated Acute Exacerbation of Interstitial Lung Disease Shortens Survival Especially in Small Cell Lung Cancer, ANTICANCER RESEARCH, 39(10), 5725-5731, 201910
  136. Role of B7H3/IL-33 Signaling in Pulmonary Fibrosis-induced Profibrogenic Alterations in Bone Marrow, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 200(8), 1032-1044, 20191015
  137. Alteration of gut microbiota by a Westernized lifestyle and its correlation with insulin resistance in non-diabetic Japanese men, JOURNAL OF DIABETES INVESTIGATION, 10(6), 1463-1470, 201911
  138. Non-small Cell Lung Cancer Treated by an Anti-programmed Cell Death-1 Antibody without a Flare-up of Preexisting Granulomatosis with Polyangiitis, INTERNAL MEDICINE, 58(21), 3129-3132, 2019
  139. Serum Antibody Against NY-ESO-1 and XAGE1 Antigens Potentially Predicts Clinical Responses to Anti-Programmed Cell Death-1 Therapy in NSCLC, JOURNAL OF THORACIC ONCOLOGY, 14(12), 2071-2083, 201912
  140. Organizing pneumonia in a carrier of human T-cell lymphotropic virus type-1, ANNALS OF THORACIC MEDICINE, 15(1), 41-43, 2020
  141. Baseline High-Resolution CT Findings Predict Acute Exacerbation of Idiopathic Pulmonary Fibrosis: German and Japanese Cohort Study, JOURNAL OF CLINICAL MEDICINE, 8(12), 201912
  142. Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production, HYPERTENSION, 75(2), 492-499, 202002
  143. Albumin-globulin ratio is a predictive biomarker of antitumor effect of anti-PD-1 antibody in patients with non-small cell lung cancer, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 25(1), 74-81, 202001
  144. Prospective, randomized, cross-over pilot study of the effects of Rikkunshito, a Japanese traditional herbal medicine, on anorexia and plasma-acylated ghrelin levels in lung cancer patients undergoing cisplatin-based chemotherapy, INVESTIGATIONAL NEW DRUGS, 38(2), 485-492, 202004
  145. Treatment rationale and design of the PROLONG study: safety and efficacy of pembrolizumab as first-line therapy for elderly patients with non-small cell lung cancer, JOURNAL OF THORACIC DISEASE, 12(3), 1079-1084, 202003
  146. Serum high-mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis, RESPIROLOGY, 25(3), 275-280, 202003
  147. Sputum Vitamin D Binding Protein (VDBP) GC1S/1S Genotype Predicts Airway Obstruction: A Prospective Study in Smokers with COPD, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 15, 1049-1059, 2020
  148. Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis, RESPIRATORY RESEARCH, 21(1), 20200611
  149. Final Results from a Phase II Trial of Osimertinib for Elderly Patients with Epidermal Growth Factor Receptor t790m-Positive Non-Small Cell Lung Cancer That Progressed during Previous Treatment, JOURNAL OF CLINICAL MEDICINE, 9(6), 202006
  150. Acute exacerbation of idiopathic interstitial pneumonias related to chemotherapy for lung cancer: nationwide surveillance in Japan, ERJ OPEN RESEARCH, 6(2), 20200401
  151. Corticosteroid therapy for organizing pneumonia in a human T-cell lymphotropic virus type-1 carrier, 25, 193-195, 2019
  152. Secondary pulmonary alveolar proteinosis in acute myeloid leukemia, QJM, 112, 293-294, 2019
  153. Acquired factor V inhibitor after antibiotic treatment in a patient with pneumonia: A case report, Annals of hematology, 98, 1989-1990, 2019
  154. Pulmonary cryptococcosis mimicking lung cancer, LANCET INFECTIOUS DISEASES, 19, 1033-1033, 2019
  155. Deep sulcus sign in pneumothorax, Archivos de Bronconeumologia, 55, 491, 2019
  156. Acquired T790M-positive squamous cell lung carcinoma that responded to osimertinib, Archivos de Bronconeumologia, 55, 602-603, 2019
  157. Endobronchial mucosa-associated lymphoid tissue (MALT) lymphoma, QJM, 112, 807-808, 2019
  158. Primary pulmonary collision tumor comprising squamous cell carcinoma and mucosa-associated lymphoid tissue lymphoma, Lung Cancer, 129, 107-109, 2019
  159. Pneumatosis cystoides intestinalis in pulmonary mycobacterial disease, British Journal of Hospital Medicine, 80, 2019
  160. Severe metastatic pulmonary calcification, American Journal of Medicine, 132, e733-e734, 2019
  161. Multiple patchy pulmonary consolidation in granulomatosis with polyangiitis, RESPIROLOGY CASE REPORTS, 8(7), 202010
  162. Serum high-mobility group box 1 as a predictive marker for cytotoxic chemotherapy-induced lung injury in patients with lung cancer and interstitial lung disease, RESPIRATORY MEDICINE, 172, 202010
  163. Extent of pulmonary fibrosis on high-resolution computed tomography is a prognostic factor in patients with pleuroparenchymal fibroelastosis, RESPIRATORY INVESTIGATION, 58(6), 465-472, 202011
  164. Coexisting TIF1 gamma-positive Primary Pulmonary Lymphoepithelioma-like Carcinoma and Anti-TIF1 gamma Antibody-positive Dermatomyositis, INTERNAL MEDICINE, 59(20), 2553-2558, 2020
  165. Association of Preexisting Interstitial Lung Abnormalities With Immune Checkpoint Inhibitor-Induced Interstitial Lung Disease Among Patients With Nonlung Cancers, JAMA NETWORK OPEN, 3(11), 20201112
  166. Clinical significance of BIM deletion polymorphism in chemoradiotherapy for non-small cell lung cancer, CANCER SCIENCE, 112(1), 369-379, 202101
  167. Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma, CLINICAL RESPIRATORY JOURNAL, 15(1), 48-55, 202101
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Publications such as books

  1. 2018/01/15, Drug-Induced Ling Injury., Blood tests for the diagnosis and/or management of DLI: what are the clinical significances of KL-6, SP-A, SP-D and DLST in DLI., Springer, 2018, Scholarly Book, Joint work