三井 伸二SHINJI MII
Last Updated :2025/06/16
- 所属・職名
- 大学院医系科学研究科(医) 教授
- メールアドレス
- miishinji
hiroshima-u.ac.jp
- 自己紹介
- がんの進展機構を含むヒト疾患の発症・増悪メカニズムを解明するため、病理学的手法を用いて臓器横断的な研究を行っています。特に、がん関連線維芽細胞に着目したがん・間質境界領域の解析を行うことで、がんと間質の相互作用の解明を目指しています。
また、病理診断も実践しており、研究と診断の両面から病理学を深く追求しています。
基本情報
主な職歴
- 2024年11月01日, 広島大学, 大学院医系科学研究科, 教授
- 2021年07月01日, 名古屋大学, 大学院医学系研究科, 准教授
学歴
- 名古屋大学, 大学院医学系研究科, 機能構築医学専攻, 日本, 2012年07月
学位
担当主専攻プログラム
研究分野
研究キーワード
所属学会
教育活動
授業担当
- 2025年, 学部専門, セメスター(後期), 臨床病理学
- 2025年, 学部専門, 2ターム, 医学研究序論
- 2025年, 学部専門, 1ターム, 病理学
- 2025年, 学部専門, 1ターム, 病理学
- 2025年, 学部専門, 1ターム, 病理学
- 2025年, 学部専門, 集中, 病因病態学
- 2025年, 学部専門, 1ターム, 病理学概論
- 2025年, 学部専門, 集中, 病理学概論
- 2025年, 教養教育, 1ターム, 教養ゼミ
- 2025年, 修士課程・博士課程前期, セメスター(前期), 特別演習
- 2025年, 修士課程・博士課程前期, セメスター(後期), 特別演習
- 2025年, 修士課程・博士課程前期, セメスター(前期), 特別研究
- 2025年, 修士課程・博士課程前期, セメスター(後期), 特別研究
- 2025年, 博士課程・博士課程後期, セメスター(前期), 特別演習
- 2025年, 博士課程・博士課程後期, セメスター(後期), 特別演習
- 2025年, 博士課程・博士課程後期, セメスター(前期), 特別研究
- 2025年, 博士課程・博士課程後期, セメスター(後期), 特別研究
- 2025年, 修士課程・博士課程前期, セメスター(後期), 病因病態学
- 2025年, 博士課程・博士課程後期, セメスター(前期), 分子病理学特別演習
- 2025年, 博士課程・博士課程後期, セメスター(後期), 分子病理学特別演習
- 2025年, 博士課程・博士課程後期, セメスター(前期), 分子病理学特別研究
- 2025年, 博士課程・博士課程後期, セメスター(後期), 分子病理学特別研究
研究活動
学術論文(★は代表的な論文)
- Superoxide dismutase 2 deficiency in mesenchymal stromal cells induces sympathetic denervation and functional impairment of brown adipose tissue., Pathology international, 75巻, 2号, 2025
- The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models., Cancer research, 85巻, 10号, 2025
- Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas., The Journal of pathology, 262巻, 1号, 2024
- CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-β Signaling., Journal of immunology (Baltimore, Md. : 1950), 212巻, 7号, 2024
- Single-cell colocalization analysis using a deep generative model., Cell systems, 15巻, 2号, 2024
- Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade., British journal of cancer, 131巻, 2号, 2024
- Meflin/ISLR is a marker of adipose stem and progenitor cells in mice and humans that suppresses white adipose tissue remodeling and fibrosis., Genes to cells : devoted to molecular & cellular mechanisms, 29巻, 10号, 2024
- CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation., American journal of respiratory cell and molecular biology, 68巻, 2号, 2023
- Significance of expression of CD109 in osteosarcoma and its involvement in tumor progression via BMP signaling., Pathology, research and practice, 245巻, 2023
- CD109 expression in tumor cells and stroma correlates with progression and prognosis in pancreatic cancer., Virchows Archiv : an international journal of pathology, 480巻, 4号, 2022
- Matrix remodeling-associated protein 8 is a marker of a subset of cancer-associated fibroblasts in pancreatic cancer., Pathology international, 72巻, 3号, 2022
- Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade., Life science alliance, 5巻, 6号, 2022
- Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics., Oncogene, 41巻, 19号, 2022
- Downregulation of ROBO4 in Pancreatic Cancer Serves as a Biomarker of Poor Prognosis and Indicates Increased Cell Motility and Proliferation Through Activation of MMP-9., Annals of surgical oncology, 29巻, 11号, 2022
- Possible disease-protective roles of fibroblasts in cancer and fibrosis and their therapeutic application., Nagoya journal of medical science, 84巻, 3号, 2022
- Detection of serum/salivary exosomal Alix in patients with oral squamous cell carcinoma., Oral diseases, 27巻, 3号, 2021
- The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis., Gastroenterology, 160巻, 4号, 2021
- Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity., Genes to cells : devoted to molecular & cellular mechanisms, 26巻, 7号, 2021
- Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells., Frontiers in cell and developmental biology, 9巻, 2021
- Hydrogen water alleviates obliterative airway disease in mice., General thoracic and cardiovascular surgery, 68巻, 2号, 2020
- The Significance of Molecular Biomarkers on Clinical Survival Outcome Differs Depending on Colon Cancer Sidedness., Anticancer research, 40巻, 1号, 2020
- Acute Exacerbation of Pleuroparenchymal Fibroelastosis Secondary to Allogenic Hematopoietic Stem Cell Transplantation., Internal medicine (Tokyo, Japan), 59巻, 21号, 2020
- Connective tissue growth factor produced by cancer‑associated fibroblasts correlates with poor prognosis in epithelioid malignant pleural mesothelioma., Oncology reports, 44巻, 3号, 2020
- Complex roles of the actin-binding protein Girdin/GIV in DNA damage-induced apoptosis of cancer cells., Cancer science, 111巻, 11号, 2020
- The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling., Biochemical and biophysical research communications, 532巻, 3号, 2020
- CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-β signaling., Cancer science, 111巻, 12号, 2020
- CD109: a multifunctional GPI-anchored protein with key roles in tumor progression and physiological homeostasis., Pathology international, 69巻, 5号, 2019
- Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction., Circulation research, 125巻, 4号, 2019
- Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis., Cancer research, 79巻, 20号, 2019
- Giant biatrial myxoma with two different gross findings., General thoracic and cardiovascular surgery, 66巻, 6号, 2018
- Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase., Biochemical and biophysical research communications, 498巻, 3号, 2018
- Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex., PLoS biology, 16巻, 3号, 2018
- Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure., Scientific reports, 8巻, 1号, 2018
- CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo., Genes to cells : devoted to molecular & cellular mechanisms, 23巻, 7号, 2018
- Girdin/GIV regulates collective cancer cell migration by controlling cell adhesion and cytoskeletal organization., Cancer science, 109巻, 11号, 2018
- Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut., The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 65巻, 6号, 2017
- Significance of perivascular tumour cells defined by CD109 expression in progression of glioma., The Journal of pathology, 243巻, 4号, 2017
- CD109 is a component of exosome secreted from cultured cells., Biochemical and biophysical research communications, 469巻, 4号, 2016
- Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells., Scientific reports, 6巻, 2016
- Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis., International journal of oncology, 49巻, 4号, 2016
- Suppression of skin tumorigenesis in CD109-deficient mice., Oncotarget, 7巻, 50号, 2016
- Girdin is phosphorylated on tyrosine 1798 when associated with structures required for migration., Biochemical and biophysical research communications, 458巻, 4号, 2015
- CD109 attenuates TGF-β1 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells., Biochemical and biophysical research communications, 459巻, 2号, 2015
- Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression., Cancer research, 75巻, 5号, 2015
- Potential involvement of kinesin-1 in the regulation of subcellular localization of Girdin., Biochemical and biophysical research communications, 463巻, 4号, 2015
- Mycobacterium tuberculosis escapes from the phagosomes of infected human osteoclasts reprograms osteoclast development via dysregulation of cytokines and chemokines., Pathogens and disease, 70巻, 1号, 2014
- Role of Girdin in intimal hyperplasia in vein grafts and efficacy of atelocollagen-mediated application of small interfering RNA for vein graft failure., Journal of vascular surgery, 60巻, 2号, 2014
- Detection of a soluble form of CD109 in serum of CD109 transgenic and tumor xenografted mice., PloS one, 9巻, 1号, 2014
- Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells., Cancer science, 105巻, 5号, 2014
- TRIM27/MRTF-B-dependent integrin β1 expression defines leading cells in cancer cell collectives., Cell reports, 7巻, 4号, 2014
- The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse., The Journal of biological chemistry, 288巻, 15号, 2013
- RET finger protein expression is associated with prognosis in lung cancer with epidermal growth factor receptor mutations., Pathology international, 62巻, 5号, 2012
- Epidermal hyperplasia and appendage abnormalities in mice lacking CD109., The American journal of pathology, 181巻, 4号, 2012
- Similar phenotypes of Girdin germ-line and conditional knockout mice indicate a crucial role for Girdin in the nestin lineage., Biochemical and biophysical research communications, 426巻, 4号, 2012
- Expression of RET finger protein predicts chemoresistance in epithelial ovarian cancer., Cancer medicine, 1巻, 2号, 2012
- Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice., Developmental biology, 349巻, 2号, 2011
- Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells., Molecular biology of the cell, 22巻, 6号, 2011
- Dedifferentiation and progression of an intracranial solitary fibrous tumor: autopsy case of a Japanese woman with a history of radiation therapy of the head during infancy., Pathology international, 61巻, 3号, 2011
- Correlation of pathological grade and tumor stage of urothelial carcinomas with CD109 expression., Pathology international, 60巻, 11号, 2010
- CD109 expression in basal-like breast carcinoma., Pathology international, 58巻, 5号, 2008
- Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase., Cancer science, 98巻, 6号, 2007
招待講演、口頭・ポスター発表等
- 線維芽細胞における調節因子PRRX2の発現および機能解析, 三井 伸二,杉戸 勇太,勝矢 脩嵩,石川 洸,榎本 篤, 第114回日本病理学会総会, 2025年04月17日, 通常, 日本語
- Exploratory Study on the Regulation of Meflin, a Marker of Cancer-Associated Fibroblasts, Shinji Mii, Yuta Sugito, Atsushi Enomoto, Eighth AACR/JCA Special Joint Conference, 2024年06月28日, 通常, 英語
- 特異的がん抑制性マーカーMeflinの転写制御に関する探索的研究, 三井 伸二,片岡 邦夫,杉戸 勇太,榎本 篤, 第113回日本病理学会総会, 2024年03月28日, 通常, 日本語
- GPI アンカー型タンパク質CD109に着目した恒常性維持および腫瘍進展機構の解明, 三井 伸二, 第69回日本病理学会総会秋期特別総会, 2023年11月10日, 招待, 日本語
- がん関連タンパク質CD109の骨肉腫における発現と腫瘍進展への関与, 三井 伸二,森 奈津美,下山 芳江,髙橋 雅英,榎本 篤, 第112回日本病理学会総会, 2023年04月15日, 通常, 日本語
外部資金
競争的資金等の採択状況
- 科学研究費助成事業 基盤研究(C), 肺癌における間質形成メカニズムと間質浸潤制御機構の解明, 2022年, 2025年
- 科学研究費助成事業 基盤研究(C), 骨肉腫マウスモデルを用いた悪性腫瘍の発症・進展におけるCD109の発現意義の解明, 2019年, 2021年
- 科学研究費助成事業 若手研究(B), 乾癬モデルマウスを用いた慢性炎症と皮膚発癌の連関解明, 2016年, 2017年
- 科学研究費助成事業 若手研究(B), 細胞融合の制御機構と腫瘍性多核巨細胞の形成メカニズムの解明, 2013年, 2015年
社会活動
委員会等委員歴
- 非常勤講師, 2025年04月, 2025年09月, 名古屋大学医学部
学術雑誌論文査読歴
- 2025年, Pathology International, 編集員
- 2024年, Pathology International, 編集員
- 2023年, Pathology International, 編集員
- 2022年, Pathology International, 編集員
- 2021年, Pathology International, 編集員