三井 伸二SHINJI MII

Last Updated :2025/06/16

所属・職名
大学院医系科学研究科(医) 教授
メールアドレス
miishinjihiroshima-u.ac.jp
自己紹介
がんの進展機構を含むヒト疾患の発症・増悪メカニズムを解明するため、病理学的手法を用いて臓器横断的な研究を行っています。特に、がん関連線維芽細胞に着目したがん・間質境界領域の解析を行うことで、がんと間質の相互作用の解明を目指しています。 また、病理診断も実践しており、研究と診断の両面から病理学を深く追求しています。

基本情報

主な職歴

  • 2024年11月01日, 広島大学, 大学院医系科学研究科, 教授
  • 2021年07月01日, 名古屋大学, 大学院医学系研究科, 准教授

学歴

  • 名古屋大学, 大学院医学系研究科, 機能構築医学専攻, 日本, 2012年07月

学位

  • 博士(医学) (名古屋大学)

担当主専攻プログラム

  • 医学プログラム

研究分野

  • 医歯薬学 / 基礎医学 / 実験病理学

研究キーワード

  • がん間質
  • 腫瘍病理学
  • 間質病理学
  • がん関連線維芽細胞

所属学会

  • 日本病理学会
  • 日本癌学会

教育活動

授業担当

  1. 2025年, 学部専門, セメスター(後期), 臨床病理学
  2. 2025年, 学部専門, 2ターム, 医学研究序論
  3. 2025年, 学部専門, 1ターム, 病理学
  4. 2025年, 学部専門, 1ターム, 病理学
  5. 2025年, 学部専門, 1ターム, 病理学
  6. 2025年, 学部専門, 集中, 病因病態学
  7. 2025年, 学部専門, 1ターム, 病理学概論
  8. 2025年, 学部専門, 集中, 病理学概論
  9. 2025年, 教養教育, 1ターム, 教養ゼミ
  10. 2025年, 修士課程・博士課程前期, セメスター(前期), 特別演習
  11. 2025年, 修士課程・博士課程前期, セメスター(後期), 特別演習
  12. 2025年, 修士課程・博士課程前期, セメスター(前期), 特別研究
  13. 2025年, 修士課程・博士課程前期, セメスター(後期), 特別研究
  14. 2025年, 博士課程・博士課程後期, セメスター(前期), 特別演習
  15. 2025年, 博士課程・博士課程後期, セメスター(後期), 特別演習
  16. 2025年, 博士課程・博士課程後期, セメスター(前期), 特別研究
  17. 2025年, 博士課程・博士課程後期, セメスター(後期), 特別研究
  18. 2025年, 修士課程・博士課程前期, セメスター(後期), 病因病態学
  19. 2025年, 博士課程・博士課程後期, セメスター(前期), 分子病理学特別演習
  20. 2025年, 博士課程・博士課程後期, セメスター(後期), 分子病理学特別演習
  21. 2025年, 博士課程・博士課程後期, セメスター(前期), 分子病理学特別研究
  22. 2025年, 博士課程・博士課程後期, セメスター(後期), 分子病理学特別研究

研究活動

学術論文(★は代表的な論文)

  1. Superoxide dismutase 2 deficiency in mesenchymal stromal cells induces sympathetic denervation and functional impairment of brown adipose tissue., Pathology international, 75巻, 2号, 2025
  2. The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models., Cancer research, 85巻, 10号, 2025
  3. Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas., The Journal of pathology, 262巻, 1号, 2024
  4. CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-β Signaling., Journal of immunology (Baltimore, Md. : 1950), 212巻, 7号, 2024
  5. Single-cell colocalization analysis using a deep generative model., Cell systems, 15巻, 2号, 2024
  6. Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade., British journal of cancer, 131巻, 2号, 2024
  7. Meflin/ISLR is a marker of adipose stem and progenitor cells in mice and humans that suppresses white adipose tissue remodeling and fibrosis., Genes to cells : devoted to molecular & cellular mechanisms, 29巻, 10号, 2024
  8. CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation., American journal of respiratory cell and molecular biology, 68巻, 2号, 2023
  9. Significance of expression of CD109 in osteosarcoma and its involvement in tumor progression via BMP signaling., Pathology, research and practice, 245巻, 2023
  10. CD109 expression in tumor cells and stroma correlates with progression and prognosis in pancreatic cancer., Virchows Archiv : an international journal of pathology, 480巻, 4号, 2022
  11. Matrix remodeling-associated protein 8 is a marker of a subset of cancer-associated fibroblasts in pancreatic cancer., Pathology international, 72巻, 3号, 2022
  12. Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade., Life science alliance, 5巻, 6号, 2022
  13. Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics., Oncogene, 41巻, 19号, 2022
  14. Downregulation of ROBO4 in Pancreatic Cancer Serves as a Biomarker of Poor Prognosis and Indicates Increased Cell Motility and Proliferation Through Activation of MMP-9., Annals of surgical oncology, 29巻, 11号, 2022
  15. Possible disease-protective roles of fibroblasts in cancer and fibrosis and their therapeutic application., Nagoya journal of medical science, 84巻, 3号, 2022
  16. Detection of serum/salivary exosomal Alix in patients with oral squamous cell carcinoma., Oral diseases, 27巻, 3号, 2021
  17. The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis., Gastroenterology, 160巻, 4号, 2021
  18. Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity., Genes to cells : devoted to molecular & cellular mechanisms, 26巻, 7号, 2021
  19. Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells., Frontiers in cell and developmental biology, 9巻, 2021
  20. Hydrogen water alleviates obliterative airway disease in mice., General thoracic and cardiovascular surgery, 68巻, 2号, 2020
  21. The Significance of Molecular Biomarkers on Clinical Survival Outcome Differs Depending on Colon Cancer Sidedness., Anticancer research, 40巻, 1号, 2020
  22. Acute Exacerbation of Pleuroparenchymal Fibroelastosis Secondary to Allogenic Hematopoietic Stem Cell Transplantation., Internal medicine (Tokyo, Japan), 59巻, 21号, 2020
  23. Connective tissue growth factor produced by cancer‑associated fibroblasts correlates with poor prognosis in epithelioid malignant pleural mesothelioma., Oncology reports, 44巻, 3号, 2020
  24. Complex roles of the actin-binding protein Girdin/GIV in DNA damage-induced apoptosis of cancer cells., Cancer science, 111巻, 11号, 2020
  25. The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling., Biochemical and biophysical research communications, 532巻, 3号, 2020
  26. CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-β signaling., Cancer science, 111巻, 12号, 2020
  27. CD109: a multifunctional GPI-anchored protein with key roles in tumor progression and physiological homeostasis., Pathology international, 69巻, 5号, 2019
  28. Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction., Circulation research, 125巻, 4号, 2019
  29. Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis., Cancer research, 79巻, 20号, 2019
  30. Giant biatrial myxoma with two different gross findings., General thoracic and cardiovascular surgery, 66巻, 6号, 2018
  31. Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase., Biochemical and biophysical research communications, 498巻, 3号, 2018
  32. Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex., PLoS biology, 16巻, 3号, 2018
  33. Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure., Scientific reports, 8巻, 1号, 2018
  34. CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo., Genes to cells : devoted to molecular & cellular mechanisms, 23巻, 7号, 2018
  35. Girdin/GIV regulates collective cancer cell migration by controlling cell adhesion and cytoskeletal organization., Cancer science, 109巻, 11号, 2018
  36. Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut., The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 65巻, 6号, 2017
  37. Significance of perivascular tumour cells defined by CD109 expression in progression of glioma., The Journal of pathology, 243巻, 4号, 2017
  38. CD109 is a component of exosome secreted from cultured cells., Biochemical and biophysical research communications, 469巻, 4号, 2016
  39. Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells., Scientific reports, 6巻, 2016
  40. Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis., International journal of oncology, 49巻, 4号, 2016
  41. Suppression of skin tumorigenesis in CD109-deficient mice., Oncotarget, 7巻, 50号, 2016
  42. Girdin is phosphorylated on tyrosine 1798 when associated with structures required for migration., Biochemical and biophysical research communications, 458巻, 4号, 2015
  43. CD109 attenuates TGF-β1 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells., Biochemical and biophysical research communications, 459巻, 2号, 2015
  44. Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression., Cancer research, 75巻, 5号, 2015
  45. Potential involvement of kinesin-1 in the regulation of subcellular localization of Girdin., Biochemical and biophysical research communications, 463巻, 4号, 2015
  46. Mycobacterium tuberculosis escapes from the phagosomes of infected human osteoclasts reprograms osteoclast development via dysregulation of cytokines and chemokines., Pathogens and disease, 70巻, 1号, 2014
  47. Role of Girdin in intimal hyperplasia in vein grafts and efficacy of atelocollagen-mediated application of small interfering RNA for vein graft failure., Journal of vascular surgery, 60巻, 2号, 2014
  48. Detection of a soluble form of CD109 in serum of CD109 transgenic and tumor xenografted mice., PloS one, 9巻, 1号, 2014
  49. Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells., Cancer science, 105巻, 5号, 2014
  50. TRIM27/MRTF-B-dependent integrin β1 expression defines leading cells in cancer cell collectives., Cell reports, 7巻, 4号, 2014
  51. The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse., The Journal of biological chemistry, 288巻, 15号, 2013
  52. RET finger protein expression is associated with prognosis in lung cancer with epidermal growth factor receptor mutations., Pathology international, 62巻, 5号, 2012
  53. Epidermal hyperplasia and appendage abnormalities in mice lacking CD109., The American journal of pathology, 181巻, 4号, 2012
  54. Similar phenotypes of Girdin germ-line and conditional knockout mice indicate a crucial role for Girdin in the nestin lineage., Biochemical and biophysical research communications, 426巻, 4号, 2012
  55. Expression of RET finger protein predicts chemoresistance in epithelial ovarian cancer., Cancer medicine, 1巻, 2号, 2012
  56. Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice., Developmental biology, 349巻, 2号, 2011
  57. Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells., Molecular biology of the cell, 22巻, 6号, 2011
  58. Dedifferentiation and progression of an intracranial solitary fibrous tumor: autopsy case of a Japanese woman with a history of radiation therapy of the head during infancy., Pathology international, 61巻, 3号, 2011
  59. Correlation of pathological grade and tumor stage of urothelial carcinomas with CD109 expression., Pathology international, 60巻, 11号, 2010
  60. CD109 expression in basal-like breast carcinoma., Pathology international, 58巻, 5号, 2008
  61. Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase., Cancer science, 98巻, 6号, 2007

招待講演、口頭・ポスター発表等

  1. 線維芽細胞における調節因子PRRX2の発現および機能解析, 三井 伸二,杉戸 勇太,勝矢 脩嵩,石川 洸,榎本 篤, 第114回日本病理学会総会, 2025年04月17日, 通常, 日本語
  2. Exploratory Study on the Regulation of Meflin, a Marker of Cancer-Associated Fibroblasts, Shinji Mii, Yuta Sugito, Atsushi Enomoto, Eighth AACR/JCA Special Joint Conference, 2024年06月28日, 通常, 英語
  3. 特異的がん抑制性マーカーMeflinの転写制御に関する探索的研究, 三井 伸二,片岡 邦夫,杉戸 勇太,榎本 篤, 第113回日本病理学会総会, 2024年03月28日, 通常, 日本語
  4. GPI アンカー型タンパク質CD109に着目した恒常性維持および腫瘍進展機構の解明, 三井 伸二, 第69回日本病理学会総会秋期特別総会, 2023年11月10日, 招待, 日本語
  5. がん関連タンパク質CD109の骨肉腫における発現と腫瘍進展への関与, 三井 伸二,森 奈津美,下山 芳江,髙橋 雅英,榎本 篤, 第112回日本病理学会総会, 2023年04月15日, 通常, 日本語

外部資金

競争的資金等の採択状況

  1. 科学研究費助成事業 基盤研究(C), 肺癌における間質形成メカニズムと間質浸潤制御機構の解明, 2022年, 2025年
  2. 科学研究費助成事業 基盤研究(C), 骨肉腫マウスモデルを用いた悪性腫瘍の発症・進展におけるCD109の発現意義の解明, 2019年, 2021年
  3. 科学研究費助成事業 若手研究(B), 乾癬モデルマウスを用いた慢性炎症と皮膚発癌の連関解明, 2016年, 2017年
  4. 科学研究費助成事業 若手研究(B), 細胞融合の制御機構と腫瘍性多核巨細胞の形成メカニズムの解明, 2013年, 2015年

社会活動

委員会等委員歴

  1. 非常勤講師, 2025年04月, 2025年09月, 名古屋大学医学部

学術雑誌論文査読歴

  1. 2025年, Pathology International, 編集員
  2. 2024年, Pathology International, 編集員
  3. 2023年, Pathology International, 編集員
  4. 2022年, Pathology International, 編集員
  5. 2021年, Pathology International, 編集員