SHINJI MII

Last Updated :2025/06/04

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Professor
E-mail
miishinjihiroshima-u.ac.jp
Self-introduction
I perform organ-agnostic research using pathological approaches to elucidate the mechanisms underlying the onset and progression of human diseases, including cancer. In particular, I focus on cancer-associated fibroblasts to analyze the tumor–stroma interface and reveal interactions between cancer and stromal components.

Basic Information

Major Professional Backgrounds

  • 2024/11/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Professor
  • 2021/07/01, Nagoya University, Graduate School of Medicine, Associate Professor

Academic Degrees

  • Nagoya University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Experimental pathology

Research Keywords

  • Malignant tumor
  • Cancer stroma
  • Tumor pathology
  • Stromal pathology
  • Cancer-associated fibroblasts

Affiliated Academic Societies

  • Japanese Society of Pathology
  • Japanese Cancer Association

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Second Semester, Clinical Pathology
  2. 2025, Undergraduate Education, 2Term, Introduction for medical research
  3. 2025, Undergraduate Education, 1Term, General Pathology
  4. 2025, Undergraduate Education, 1Term, Pathology
  5. 2025, Undergraduate Education, 1Term, Pathology
  6. 2025, Undergraduate Education, Intensive, Pathology
  7. 2025, Undergraduate Education, 1Term, Outline of Pathology
  8. 2025, Undergraduate Education, Intensive, Outline of Pathology
  9. 2025, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  10. 2025, Graduate Education (Master's Program) , First Semester, Seminar
  11. 2025, Graduate Education (Master's Program) , Second Semester, Seminar
  12. 2025, Graduate Education (Master's Program) , First Semester, Research
  13. 2025, Graduate Education (Master's Program) , Second Semester, Research
  14. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  15. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  16. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  17. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  18. 2025, Graduate Education (Master's Program) , Second Semester, Pathologic Basis of Diseases
  19. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Molecular Pathology
  20. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Molecular Pathology
  21. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Molecular Pathology
  22. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Molecular Pathology

Research Activities

Academic Papers

  1. Superoxide dismutase 2 deficiency in mesenchymal stromal cells induces sympathetic denervation and functional impairment of brown adipose tissue., Pathology international, 75(2), 2025
  2. The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models., Cancer research, 85(10), 2025
  3. Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas., The Journal of pathology, 262(1), 2024
  4. CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-beta Signaling., Journal of immunology (Baltimore, Md. : 1950), 212(7), 2024
  5. Single-cell colocalization analysis using a deep generative model., Cell systems, 15(2), 2024
  6. Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade., British journal of cancer, 131(2), 2024
  7. Meflin/ISLR is a marker of adipose stem and progenitor cells in mice and humans that suppresses white adipose tissue remodeling and fibrosis., Genes to cells : devoted to molecular & cellular mechanisms, 29(10), 2024
  8. CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation., American journal of respiratory cell and molecular biology, 68(2), 2023
  9. Significance of expression of CD109 in osteosarcoma and its involvement in tumor progression via BMP signaling., Pathology, research and practice, 245, 2023
  10. CD109 expression in tumor cells and stroma correlates with progression and prognosis in pancreatic cancer., Virchows Archiv : an international journal of pathology, 480(4), 2022
  11. Matrix remodeling-associated protein 8 is a marker of a subset of cancer-associated fibroblasts in pancreatic cancer., Pathology international, 72(3), 2022
  12. Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade., Life science alliance, 5(6), 2022
  13. Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics., Oncogene, 41(19), 2022
  14. Downregulation of ROBO4 in Pancreatic Cancer Serves as a Biomarker of Poor Prognosis and Indicates Increased Cell Motility and Proliferation Through Activation of MMP-9., Annals of surgical oncology, 29(11), 2022
  15. Possible disease-protective roles of fibroblasts in cancer and fibrosis and their therapeutic application., Nagoya journal of medical science, 84(3), 2022
  16. Detection of serum/salivary exosomal Alix in patients with oral squamous cell carcinoma., Oral diseases, 27(3), 2021
  17. The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis., Gastroenterology, 160(4), 2021
  18. Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity., Genes to cells : devoted to molecular & cellular mechanisms, 26(7), 2021
  19. Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells., Frontiers in cell and developmental biology, 9, 2021
  20. Hydrogen water alleviates obliterative airway disease in mice., General thoracic and cardiovascular surgery, 68(2), 2020
  21. The Significance of Molecular Biomarkers on Clinical Survival Outcome Differs Depending on Colon Cancer Sidedness., Anticancer research, 40(1), 2020
  22. Acute Exacerbation of Pleuroparenchymal Fibroelastosis Secondary to Allogenic Hematopoietic Stem Cell Transplantation., Internal medicine (Tokyo, Japan), 59(21), 2020
  23. Connective tissue growth factor produced by cancer‑associated fibroblasts correlates with poor prognosis in epithelioid malignant pleural mesothelioma., Oncology reports, 44(3), 2020
  24. Complex roles of the actin-binding protein Girdin/GIV in DNA damage-induced apoptosis of cancer cells., Cancer science, 111(11), 2020
  25. The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling., Biochemical and biophysical research communications, 532(3), 2020
  26. CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-beta signaling., Cancer science, 111(12), 2020
  27. CD109: a multifunctional GPI-anchored protein with key roles in tumor progression and physiological homeostasis., Pathology international, 69(5), 2019
  28. Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction., Circulation research, 125(4), 2019
  29. Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis., Cancer research, 79(20), 2019
  30. Giant biatrial myxoma with two different gross findings., General thoracic and cardiovascular surgery, 66(6), 2018
  31. Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase., Biochemical and biophysical research communications, 498(3), 2018
  32. Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex., PLoS biology, 16(3), 2018
  33. Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure., Scientific reports, 8(1), 2018
  34. CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo., Genes to cells : devoted to molecular & cellular mechanisms, 23(7), 2018
  35. Girdin/GIV regulates collective cancer cell migration by controlling cell adhesion and cytoskeletal organization., Cancer science, 109(11), 2018
  36. Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut., The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 65(6), 2017
  37. Significance of perivascular tumour cells defined by CD109 expression in progression of glioma., The Journal of pathology, 243(4), 2017
  38. CD109 is a component of exosome secreted from cultured cells., Biochemical and biophysical research communications, 469(4), 2016
  39. Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells., Scientific reports, 6, 2016
  40. Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis., International journal of oncology, 49(4), 2016
  41. Suppression of skin tumorigenesis in CD109-deficient mice., Oncotarget, 7(50), 2016
  42. Girdin is phosphorylated on tyrosine 1798 when associated with structures required for migration., Biochemical and biophysical research communications, 458(4), 2015
  43. CD109 attenuates TGF-beta1 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells., Biochemical and biophysical research communications, 459(2), 2015
  44. Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression., Cancer research, 75(5), 2015
  45. Potential involvement of kinesin-1 in the regulation of subcellular localization of Girdin., Biochemical and biophysical research communications, 463(4), 2015
  46. Mycobacterium tuberculosis escapes from the phagosomes of infected human osteoclasts reprograms osteoclast development via dysregulation of cytokines and chemokines., Pathogens and disease, 70(1), 2014
  47. Role of Girdin in intimal hyperplasia in vein grafts and efficacy of atelocollagen-mediated application of small interfering RNA for vein graft failure., Journal of vascular surgery, 60(2), 2014
  48. Detection of a soluble form of CD109 in serum of CD109 transgenic and tumor xenografted mice., PloS one, 9(1), 2014
  49. Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells., Cancer science, 105(5), 2014
  50. TRIM27/MRTF-B-dependent integrin beta1 expression defines leading cells in cancer cell collectives., Cell reports, 7(4), 2014
  51. The REV7 subunit of DNA polymerase zeta is essential for primordial germ cell maintenance in the mouse., The Journal of biological chemistry, 288(15), 2013
  52. RET finger protein expression is associated with prognosis in lung cancer with epidermal growth factor receptor mutations., Pathology international, 62(5), 2012
  53. Epidermal hyperplasia and appendage abnormalities in mice lacking CD109., The American journal of pathology, 181(4), 2012
  54. Similar phenotypes of Girdin germ-line and conditional knockout mice indicate a crucial role for Girdin in the nestin lineage., Biochemical and biophysical research communications, 426(4), 2012
  55. Expression of RET finger protein predicts chemoresistance in epithelial ovarian cancer., Cancer medicine, 1(2), 2012
  56. Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice., Developmental biology, 349(2), 2011
  57. Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells., Molecular biology of the cell, 22(6), 2011
  58. Dedifferentiation and progression of an intracranial solitary fibrous tumor: autopsy case of a Japanese woman with a history of radiation therapy of the head during infancy., Pathology international, 61(3), 2011
  59. Correlation of pathological grade and tumor stage of urothelial carcinomas with CD109 expression., Pathology international, 60(11), 2010
  60. CD109 expression in basal-like breast carcinoma., Pathology international, 58(5), 2008
  61. Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase., Cancer science, 98(6), 2007